High throughput pipetting apparatus

Abstract

The invention relates to high-throughput pipetting equipment. The high-throughput pipetting equipment comprises a rack; the pipetting mechanism comprises a pipetting needle, and the pipetting needle is movably arranged in the rack; the conveying mechanism comprises a conveying part and a limiting part, and the conveying part is movably arranged in the rack in the first horizontal direction; the conveying piece is provided with a first container placing position, and a second container placing position is arranged in the rack; the pipetting needle can respectively move to positions above the first container placing position and the second container placing position; the limiting piece is movably arranged in the rack and has an initial state and a limiting state, when the limiting piece is in the initial state, the limiting piece avoids the first container, and the conveying piece drives the first container to move and pass through a preset position; when the limiting piece is in the limiting state, the limiting piece and the first container are in limiting fit at the preset position. According to the equipment disclosed by the invention, the first container is limited through the limiting piece, so that the first container is stably fixed on the conveying piece, and accurate interaction between components in the high-throughput pipetting equipment and the first container is facilitated.

Description

Technical Field

[0001] This application relates to the field of liquid handling technology, and in particular to high-throughput liquid handling equipment. Background Technology

[0002] Pipetting is an indispensable basic operation in fields such as biology and medicine, and a crucial foundational step in various experimental research. Automated pipetting equipment is mainly used to achieve high-precision and highly repeatable liquid transfer operations. It can automate delicate liquid handling tasks such as gradient dilution, pipetting, and liquid merging, effectively reducing the workload of laboratory personnel, minimizing human error, improving the repeatability and accuracy of experiments, and reducing the risk of sample contamination.

[0003] However, current automated pipetting equipment still has certain limitations in terms of operational flexibility and automation. On the one hand, when faced with non-standardized procedures or operations requiring temporary adjustments, the equipment lacks flexibility and struggles to quickly adapt to diverse experimental needs. On the other hand, although some equipment has a high level of automation, manual intervention is still required in practical applications, such as replacing consumables or handling abnormal situations. This makes it difficult to achieve true full-process automation and long-term unattended operation, thus limiting the improvement of overall work efficiency. Summary of the Invention

[0004] Based on this, this application provides a high-throughput pipetting device to solve at least one of the technical problems existing in the prior art.

[0005] This application provides a high-throughput pipetting device, comprising: a frame; a pipetting mechanism including a pipetting needle movably disposed within the frame; a transport mechanism including a transport member and a limiting member, the transport member being movably disposed within the frame along a first horizontal direction; the transport member having a first container placement position, and the frame having a second container placement position; the pipetting needle being movable above the first and second container placement positions respectively; the limiting member being movably disposed within the frame and having an initial state and a limiting state, wherein when the limiting member is in the initial state, the limiting member avoids the first container, and the transport member drives the first container to move past a preset position; and when the limiting member is in the limiting state, the limiting member and the first container are mutually limitingly engaged at the preset position.

[0006] In one embodiment, the high-throughput pipetting apparatus further includes a heat-sealing mechanism, which includes a feeding component and a sealing component. The feeding component is used to deliver the heat-sealing film to the sealing component, and the sealing component is used to heat-seal the heat-sealing film onto a first container.

[0007] In one embodiment, the heat sealing mechanism further includes a receiving component movably disposed within a frame; the receiving component has a receiving position corresponding to the conveyor and a sealing position corresponding to the sealing component; when the receiving component moves to the receiving position, the first container can be transferred from the conveyor to the receiving component; when the receiving component moves to the sealing position, the sealing component heat seals the heat-sealing film onto the first container.

[0008] In one embodiment, the high-throughput pipetting apparatus further includes a stacking mechanism located on the side of the delivery mechanism away from the heat-sealing mechanism; the stacking mechanism includes a transfer assembly and a storage unit, the storage unit being used to store a first container, the transfer assembly being movably disposed within the frame, and the transfer assembly being capable of transferring the first container from the receiving assembly to the storage unit.

[0009] In one embodiment, the stacking mechanism further includes a lifting assembly, the storage unit extending vertically, the lifting assembly being located on the side of the transfer assembly away from the storage unit in the vertical direction; the transfer assembly is movable horizontally to transfer the first container from the receiving assembly to the transfer assembly; the lifting assembly is movable vertically to transfer the first container from the transfer assembly to the storage unit.

[0010] In one embodiment, the stacking mechanism further includes a support component disposed on the storage unit. The support component includes a support member movably disposed on the storage unit and has a limiting state and a clearance state. When the support member is in the limiting state, the support member supports and cooperates with the first container. When the support member is in the clearance state, the support member clears the first container, so that the lifting component can drive the first container over the support member.

[0011] In one embodiment, the stacking mechanism further includes a lifting component and a rotating component. The lifting component is movably disposed on the frame in a vertical direction, the rotating component is rotatably disposed on the lifting component about an axis extending in a vertical direction, and the transfer component is movably disposed on the rotating component in a horizontal direction.

[0012] In one embodiment, the transfer assembly includes a transfer frame and a transfer belt, the transfer belt being rotatably disposed on the transfer frame in a horizontal direction, the transfer belt being capable of transferring the first container to the storage component; one of the transfer belt and the conveyor is provided with a docking hole, and the other of the transfer belt and the conveyor is provided with a docking post, the docking hole and the docking post being inserted into each other.

[0013] In one embodiment, the encapsulation assembly includes a clamping assembly, a cutting assembly, and a heat-sealing assembly. When the receiving assembly moves to the encapsulation position, the clamping assembly, the receiving assembly, the cutting assembly, and the feeding assembly are spaced apart along a second horizontal direction, and the heat-sealing assembly is located above the receiving assembly in the vertical direction. The clamping assembly is used to clamp the heat-sealing film so that the heat-sealing film passes sequentially from the feeding assembly through the cutting assembly and the encapsulation position. The heat-sealing assembly is movable in the vertical direction to heat-seal the heat-sealing film to a first container located on the receiving assembly.

[0014] In one embodiment, the heat sealing mechanism further includes a traction assembly, which includes a traction member and a first reset member. The traction member is disposed on the clamping assembly, which is movable along a second horizontal direction to drive the cutting assembly to the cutting position via the traction member. The first reset member is connected to the cutting assembly and the frame respectively to move the cutting assembly to the avoidance position.

[0015] In one embodiment, the traction member includes a swing hook and a second reset member. The swing hook is swayably disposed on the clamping assembly, and the second reset member is disposed between the swing hook and the clamping assembly. A first protrusion is provided in the frame, and a second protrusion is provided on the cutting assembly. When the clamping assembly moves toward the cutting assembly, the first protrusion drives the swing hook to swing so that the swing hook hooks onto the first protrusion. The second protrusion can drive the swing hook to swing so that the swing hook separates from the first protrusion.

[0016] In one embodiment, the limiting member includes a first clamping member and a second clamping member, which are spaced apart along a first horizontal direction. Both the first clamping member and the second clamping member can switch between an initial state and a limiting state. When the limiting member switches from the initial state to the limiting state, the first clamping member and the second clamping member can respectively limit and cooperate with the opposite sides of the container.

[0017] Applying the technical solution of this application, a first container is placed on the conveyor of the conveying mechanism. The conveyor carries the first container, and by moving the conveyor along a first horizontal direction, it can drive the first container to move along the same direction. At this time, the limiting member is in its initial state of avoiding the first container. When the limiting member switches from the initial state to the limiting state, it can cooperate with the first container to limit its position, allowing the first container to remain relatively stationary with the limiting member, thus confining the first container to a specific position. Then, a pipette is moved to the second container placement position, and liquid is drawn from the second container placed there. The pipette is then moved back to the first container placement position, and the liquid drawn from the pipette is released into the first container at that position. Using the high-throughput pipetting device of this application, the limiting member confines the first container, securing it firmly on the conveyor, facilitating precise interaction between other components within the high-throughput pipetting device and the first container. Attached Figure Description

[0018] Figure 1 A schematic diagram of the structure of the high-throughput pipetting device provided in an embodiment of this application is shown.

[0019] Figure 2 A schematic diagram of the heat sealing mechanism of the high-throughput pipetting device provided in this application embodiment is shown.

[0020] Figure 3 A partial structural diagram of the heat sealing mechanism of the high-throughput pipetting device provided in this application embodiment is shown.

[0021] Figure 4 This illustration shows another part of the structural diagram of the heat sealing mechanism of the high-throughput pipetting device provided in the embodiments of this application.

[0022] Figure 5 A schematic diagram of the receiving component of the high-throughput pipetting device provided in an embodiment of this application is shown.

[0023] Figure 6 A schematic diagram of the heat-sealing assembly of the high-throughput pipetting device provided in this application embodiment is shown.

[0024] Figure 7 A schematic diagram of the cutting component of the high-throughput pipetting device provided in this application embodiment is shown.

[0025] Figure 8 A schematic diagram of the clamping assembly of the high-throughput pipetting device provided in this application embodiment is shown.

[0026] Figure 9 A schematic diagram of the traction component of the high-throughput pipetting device provided in this application embodiment is shown.

[0027] Figure 10 A schematic diagram of the clamping assembly, traction assembly, and receiving assembly of the high-throughput pipetting device provided in an embodiment of this application is shown.

[0028] Figure 11 A schematic diagram of the clamping assembly, traction assembly, and receiving assembly of the high-throughput pipetting device provided in an embodiment of this application is shown.

[0029] Figure 12 A schematic diagram of the loading assembly of the high-throughput pipetting device provided in this application embodiment is shown.

[0030] Figure 13 This illustration shows another structural schematic diagram of the loading assembly of the high-throughput pipetting device provided in an embodiment of this application.

[0031] Figure 14A schematic diagram of the frame and pipetting mechanism of the high-throughput pipetting device provided in this application embodiment is shown.

[0032] Figure 15 A schematic diagram of the pipetting mechanism of the high-throughput pipetting device provided in this application embodiment is shown.

[0033] Figure 16 A schematic diagram of the drive mechanism of the high-throughput pipetting device provided in an embodiment of this application is shown.

[0034] Figure 17 A schematic diagram of the stack mechanism of the high-throughput pipetting device provided in Embodiment 1 of this application is shown.

[0035] Figure 18 A partial schematic diagram of the stacking mechanism of the high-throughput pipetting device provided in Embodiment 1 of this application is shown.

[0036] Figure 19 A cross-sectional view of the stack mechanism of the high-throughput pipetting device provided in Embodiment 1 of this application is shown.

[0037] Figure 20 A front view of the stack mechanism of the high-throughput pipetting device provided in Embodiment 1 of this application is shown.

[0038] Figure 21 A schematic diagram of the lifting assembly of the high-throughput pipetting device provided in Embodiment 1 of this application is shown.

[0039] Figure 22 A schematic diagram of the transfer component of the high-throughput pipetting device provided in Embodiment 1 of this application is shown.

[0040] Figure 23 A schematic diagram of the stack mechanism of the high-throughput pipetting device provided in Embodiment 2 of this application is shown.

[0041] Figure 24 This paper shows another schematic diagram of the stack mechanism of the high-throughput pipetting device provided in Embodiment 2 of this application.

[0042] Figure 25 A schematic diagram of the lifting assembly of the high-throughput pipetting device provided in Embodiment 2 of this application is shown.

[0043] Figure 26 This paper shows another structural schematic diagram of the lifting component of the high-throughput pipetting device provided in Embodiment 2 of this application.

[0044] Figure 27 A schematic diagram of the rotating assembly of the high-throughput pipetting device provided in Embodiment 2 of this application is shown.

[0045] Figure 28A schematic diagram of the transfer component of the high-throughput pipetting device provided in Embodiment 2 of this application is shown.

[0046] Figure 29 A schematic diagram of the delivery mechanism of the high-throughput pipetting device provided in this application embodiment is shown.

[0047] Figure 30 This paper shows another structural schematic diagram of the delivery mechanism of the high-throughput pipetting device provided in an embodiment of this application.

[0048] Figure 31 A diagram showing the connection between the conveyor belt and the first transfer belt of the high-throughput pipetting device provided in this application embodiment is shown.

[0049] Explanation of reference numerals in the attached figures:

[0050] 10. Frame; 11. First container placement position; 12. Second container placement position; 17. Longitudinal beam; 18. First protrusion; 19. Guide frame; 20. Pipetting mechanism; 21. Pipetting rack; 22. Pipetting chamber; 221. Air inlet; 23. Pipetting needle; 24. First valve; 25. Pipetting shaft; 26. Pipetting drive component; 40. Drive mechanism; 41. Crossbeam; 42. First drive component; 43. Second drive component; 44. Third drive component; 50. Heat sealing mechanism; 51. Feeding assembly; 511. Rewinding shaft; 512 513. Feeding drive wheel; 514. Feeding driven wheel; 515. Adjusting block; 52. Receiving assembly; 521. Receiving frame; 522. Receiving tray; 53. Clamping assembly; 531. Clamping frame; 532. Fixed clamp; 533. Moving clamp; 534. Cam; 535. Drive rod; 5351. Slide groove; 54. Cutting assembly; 541. Second protrusion; 542. Cutting frame; 543. Cutting blade; 544. Third reset component; 55. Heat sealing assembly; 551. Fixing plate; 552. Heating plate; 5 53. Elastic element; 554. Suction cup; 555. Suction cup shaft; 56. Traction assembly; 561. Swing hook; 5611. Guide block; 5612. Hook; 70. Stacking mechanism; 71. Transfer assembly; 711. First transfer frame; 712. First transfer belt; 713. Second transfer frame; 714. Second transfer belt; 715. Pallet; 72. Storage component; 73. Lifting assembly; 731. Lifting drive component; 732. Lifting seat; 733. Lifting rod; 734. Lifting plate; 74. Support assembly; 741. 742. Support component; 743. Support drive component; 75. Linkage rod; 76. Lifting assembly; 77. Lifting frame; 78. Lifting belt; 79. Counterweight rope; 70. Counterweight component; 71. Rotating assembly; 72. Rotating frame; 73. Rotating wheel; 74. Stacking support; 85. Conveying mechanism; 86. Conveying frame; 87. Conveying belt; 88. Limiting component; 89. First clamping component; 80. Second clamping component; 81. Conveying drive component; 82. Abutment component; 83. Guide component; 84. Docking hole; 85. Docking post. Detailed Implementation

[0051] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, the specific embodiments of this application are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0052] See Figure 1 and Figure 14 , Figure 1A schematic diagram of the structure of the high-throughput pipetting device provided in an embodiment of this application is shown. Figure 14 This illustration shows a schematic diagram of the frame and pipetting mechanism of a high-throughput pipetting device provided in an embodiment of this application. Embodiment 1 of this application provides a high-throughput pipetting device, which includes a frame 10, a pipetting mechanism 20, and a delivery mechanism 80. The pipetting mechanism 20 includes a pipetting needle 23, which is movably disposed within the frame 10. The delivery mechanism 80 includes a delivery member and a limiting member 83. The delivery member is movably disposed within the frame 10 along a first horizontal direction X; the delivery member has a first container placement position, and the frame 10 has a second container placement position; the pipetting needle 23 can move above the first and second container placement positions respectively; the limiting member 83 is movably disposed within the frame 10 and has an initial state and a limiting state. When the limiting member 83 is in the initial state, it avoids the first container, and the delivery member drives the first container to move past a preset position; when the limiting member 83 is in the limiting state, it engages with the first container at the preset position.

[0053] Applying the technical solution of this application, a first container is placed on the conveyor of the conveying mechanism 80. The conveyor carries the first container, and by moving the conveyor along the first horizontal direction X, the conveyor can drive the first container to move along the first horizontal direction X. At this time, the limiting member 83 is in the initial state of avoiding the first container. When the limiting member 83 switches from the initial state to the limiting state, the limiting member 83 can cooperate with the first container to limit it, so that the first container can be relatively stationary with the limiting member 83, thereby limiting the first container to a specific position. At this time, the pipette 23 is moved to the second container placement position, and then the pipette 23 is used to draw liquid from the second container placed at the second container placement position. Then, the pipette 23 is moved to the first container placement position, and the liquid drawn by the pipette 23 is released into the first container at the first container placement position. Using the high-throughput pipetting device of this application, the limiting member 83 limits the first container, making it stable on the conveyor, which facilitates precise interaction between other components in the high-throughput pipetting device and the first container.

[0054] The conveyor component uses a reciprocating conveyor belt 82.

[0055] Figure 15 A schematic diagram of the pipetting mechanism of the high-throughput pipetting device provided in an embodiment of this application is shown. (Combined with...) Figure 15 As shown, in some embodiments, the pipetting mechanism 20 further includes a pipette 21 and a pipetting chamber 22, with the pipetting needle 23 connected to the pipetting chamber 22. The pipette 21 is movably disposed on the frame 10 to drive the pipetting needle 23 to move above the first container placement position 11 and above the second container placement position 12, respectively.

[0056] The pipetting chamber 22 is provided with an air inlet 221 that is connected to a compressed air source. The pipetting mechanism 20 also includes a first valve 24. When the pipetting needle 23 sprays liquid, the first valve 24 opens, and the compressed air source provides pressure to the pipetting chamber 22. The two ends of the first valve 24 are connected to the air inlet 221 and the pipetting chamber 22 respectively, thereby pressurizing the liquid in the pipetting chamber 22 and spraying it out from the pipetting needle 23.

[0057] In some embodiments, the pipetting mechanism 20 further includes a pipetting shaft 25 and a pipetting drive 26, the pipetting drive 26 being drivenly connected to the pipetting shaft 25 so that the pipetting shaft 25 is movably disposed within the pipetting chamber 22. When the pipetting needle 23 draws liquid, the first valve 24 is closed, and the pipetting shaft 25 moves in a direction away from the pipetting needle 23.

[0058] Figure 16 A schematic diagram of the drive mechanism of the high-throughput pipetting device provided in an embodiment of this application is shown. (Combined with...) Figure 16 As shown, a longitudinal beam 17 is fixedly mounted on the frame 10, extending along a first horizontal direction X. A drive mechanism 40 is installed within the frame 10. The drive mechanism 40 includes a crossbeam 41, a first drive member 42, a second drive member 43, and a third drive member 44. The first drive member 42 is drivenly connected to the crossbeam 41, allowing the crossbeam 41 to be movably mounted on the longitudinal beam 17 along the first horizontal direction X. The crossbeam 41 extends along a second horizontal direction Y. The second drive member 43 is mounted on the crossbeam 41 and drivenly connected to a pipette 21, allowing the pipette 21 to move along the second horizontal direction Y. The third drive member 44 is mounted on the pipette 21 and drivenly connected to a pipette needle 23, allowing the pipette needle 23 to move along the vertical direction Z.

[0059] It should be noted that the second container can hold samples or reagents. The second container can be different types of sample or reagent containers, such as 96-well plates, 384-well plates, 1536-well plates that meet SBS standards, or other homemade containers.

[0060] Figure 29 A schematic diagram of the delivery mechanism of the high-throughput pipetting device provided in this application embodiment is shown. Figure 30 This illustration shows another structural schematic diagram of the delivery mechanism of the high-throughput pipetting device provided in an embodiment of this application. Combined with... Figure 29 and Figure 30As shown, in some embodiments, the limiting member 83 includes a first clamping member 831 and a second clamping member 832. The first clamping member 831 and the second clamping member 832 are spaced apart along a first horizontal direction X, and the first clamping member 831 and the second clamping member 832 can rotate about an axis extending along a vertical direction Z. Both the first clamping member 831 and the second clamping member 832 can switch between an initial state and a limiting state. When the limiting member switches from the initial state to the limiting state, the first clamping member 831 and the second clamping member 832 can respectively limit and cooperate with the opposite sides of the first container. When the first container is located in the first container placement position 11, the first clamping member 831 and the second clamping member 832 can respectively abut against the first container, thereby clamping the first container. When the conveyor belt 82 moves the first container, the first clamping member 831 and the second clamping member 832 can avoid the first container.

[0061] The conveying mechanism 80 further includes a conveying drive 84, and the first clamping member 831 and the second clamping member 832 are respectively driven by the conveying drive 84. In some embodiments, the conveying drive 84 includes an encoder motor. The encoder motor enables semi-closed-loop control, and the microstepping control of the encoder motor enables precise clamping and positioning of the clamping members.

[0062] In other embodiments, other power mechanisms such as push-pull cylinders, rotary cylinders, hydraulic cylinders, electromagnets, or servo motors can be used as driving components to drive the first clamping member 831 and the second clamping member 832 to swing. However, using a cylinder requires a compressed air source, and using a hydraulic cylinder requires a hydraulic oil source. Using an encoder motor, on the other hand, does not require an additional power source; only electrical energy needs to be converted into the motor's mechanical energy.

[0063] Furthermore, the encoder motor can automatically control the motor's rotation angle, speed, and movement time, thereby automatically controlling the movement time and state of the first clamping member 831 and the second clamping member 832. Simultaneously, the torque feedback during motor shaft rotation can be used to adjust the clamping force to prevent container deformation. The motor rotation can be considered uniform motion, preventing overshoot.

[0064] Combination Figure 30As shown, the conveying mechanism 80 also includes an abutment member 85, which is disposed on the conveying frame 81. The abutment member 85 and the first clamping member 831 are located on both sides of the conveying frame 81. Both the first clamping member 831 and the second clamping member 832 are provided with abutment ramps. The abutment ramps of the first clamping member 831 and the second clamping member 832 can abut against the container, so that the abutment member 85 abuts against the first container. With the above design, during the process of clamping the container by the first clamping member 831 and the second clamping member 832, the abutment ramps of the two clamping members can generate a pushing force on the container, thereby causing the container to move towards the abutment member 85. Then, the abutment member 85, the first clamping member 831, and the second clamping member 832 work together to fix the container, making the container more secure.

[0065] Combination Figure 30 As shown, the conveying mechanism 80 also includes guide members 86, which are disposed on the conveying frame 81. Guide members 86 are provided on both sides of the conveying component along the vertical direction Z, and guide ramps are provided at both ends of the guide members 86 along the first horizontal direction X. With this design, the guide ramps can guide the first container, reducing the offset of the first container on different conveying components during conveying, allowing the first container to be held in an appropriate position on the conveyor belt 82 and move along the moving direction of the conveyor belt 82.

[0066] Figure 2 A schematic diagram of the heat sealing mechanism of the high-throughput pipetting device provided in this application embodiment is shown. Figure 3 A partial structural diagram of the heat sealing mechanism of the high-throughput pipetting device provided in this application embodiment is shown. Figure 4 This diagram illustrates a further portion of the structural structure of the heat-sealing mechanism of the high-throughput pipetting device provided in an embodiment of this application. (In conjunction with...) Figures 2 to 4 As shown, the high-throughput pipetting equipment also includes a heat-sealing mechanism 50, which includes a feeding component 51 and a sealing component. The feeding component 51 is used to transport the heat-sealing film to the sealing component, and the sealing component is used to heat-seal the heat-sealing film onto the first container. With this design, the feeding component 51 can feed the heat-sealing film to the first container, and the sealing component can then heat-seal the film onto the first container, thereby automating the operation of the high-throughput pipetting equipment and reducing human intervention.

[0067] Combination Figure 2As shown, the heat-sealing mechanism 50 also includes a receiving component 52, which is movably disposed within the frame 10. The receiving component 52 has a receiving position corresponding to the conveyor and a sealing position corresponding to the sealing component. When the receiving component 52 moves to the receiving position, the first container can be transferred from the conveyor to the receiving component 52. When the receiving component 52 moves to the sealing position, the sealing component heat-seals the heat-sealing film onto the first container. Using this design, after transferring the liquid from the second container to the first container, the receiving component 52 can be moved to the receiving position, thereby transferring the first container to the receiving component 52. Then, the receiving component 52 can be moved to the sealing position, whereby the sealing component can heat-seal the sealing film onto the first container.

[0068] In some embodiments, the receiving component 52 includes a receiving rack 521 and a receiving tray 522 disposed on the receiving rack 521. The receiving rack 521 is movably disposed along a first horizontal direction X, and a first container is placed on the receiving tray 522.

[0069] Combination Figure 3 and Figure 4 As shown, the encapsulation assembly includes a clamping assembly 53, a cutting assembly 54, and a heat-sealing assembly 55. When the receiving assembly 52 moves to the encapsulation position, the clamping assembly 53, the receiving assembly 52, the cutting assembly 54, and the feeding assembly 51 are spaced apart along the second horizontal direction Y. The heat-sealing assembly 55 is located above the receiving assembly 52 in the vertical direction Z. The clamping assembly 53 is used to clamp the heat-sealing film so that the heat-sealing film passes sequentially from the feeding assembly 51 through the cutting assembly 54 and the encapsulation position. The heat-sealing assembly 55 can move along the vertical direction Z to heat-seal the heat-sealing film into the first container located in the receiving assembly 52. ​​With the above design, the clamping assembly 53 can drive the heat-sealing film to move, and then the receiving assembly 52 can drive the first container to the encapsulation position. Then, the cutting assembly 54 can cut the heat-sealing film at a suitable position to give the heat-sealing film a suitable length, and the heat-sealing assembly 55 can encapsulate the heat-sealing film into the first container, realizing an automated heat-sealing film encapsulation process.

[0070] The feeding assembly 51 is equipped with a winding shaft 511 on which the heat-sealing film is wound up. The clamping assembly 53 of this application can realize the fixed-length movement of the heat-sealing film, and the cutting assembly 54 can realize the precise cutting of the heat-sealing film, so that the utilization rate of the film material can be greatly improved.

[0071] Figure 12 A schematic diagram of the loading assembly of the high-throughput pipetting device provided in this application embodiment is shown. Figure 13 This illustration shows another structural schematic diagram of the loading assembly of the high-throughput pipetting device provided in an embodiment of this application. (Combined with...) Figure 12 and Figure 13As shown, the feeding assembly 51 also includes a feeding frame 512, a feeding drive wheel 513, and a feeding driven wheel 514. Both the feeding drive wheel 513 and the feeding driven wheel 514 are rotatably mounted on the feeding frame 512. The heat-sealing film passes through the gap between the feeding drive wheel 513 and the feeding driven wheel 514, and the feeding drive wheel 513 can move closer to or further away from the feeding driven wheel 514 to adjust the position of the heat-sealing film. Furthermore, the feeding assembly 51 also includes an adjusting block 515, which can be adjusted to accommodate heat-sealing films of different widths.

[0072] Figure 8 A schematic diagram of the clamping assembly of the high-throughput pipetting device provided in an embodiment of this application is shown. (Combined with...) Figure 8 As shown, the clamping assembly 53 includes a clamping frame 531, a fixed clamp 532, a movable clamp 533, and a cam 534. The fixed clamp 532 is fixedly mounted on the clamping frame 531. The cam 534 is rotatably mounted on the clamping frame 531 and is connected to the movable clamp 533, allowing the movable clamp 533 to swing on the clamping frame 531. Both the movable clamp 533 and the fixed clamp 532 are equipped with magnets. When the two magnets attract each other, the heat-sealing film can be clamped between the movable clamp 533 and the fixed clamp 532. By rotating the cam 534, the movable clamp 533 can be separated from the fixed clamp 532, thereby releasing the heat-sealing film.

[0073] Figure 9 A schematic diagram of the traction component of the high-throughput pipetting device provided in this application embodiment is shown. Figure 10 A schematic diagram of the clamping assembly, traction assembly, and receiving assembly of the high-throughput pipetting device provided in this application embodiment is shown. Figure 11 This illustration shows another structural schematic diagram of the clamping assembly, traction assembly, and receiving assembly of the high-throughput pipetting device provided in an embodiment of this application. (In conjunction with...) Figures 9 to 11 As shown, the heat-sealing mechanism 50 also includes a traction assembly 56, which includes a traction member and a first reset member. The traction member is disposed on the clamping assembly 53, which is capable of moving along the second horizontal direction Y to drive the cutting assembly 54 to the cutting position via the traction member. The first reset member is connected to both the cutting assembly 54 and the frame 10 to move the cutting assembly 54 to an avoidance position. With the above design, the clamping assembly 53 can drive the cutting assembly 54 to the cutting position via the traction member to complete the cutting of the heat-sealing film. The first reset member can drive the cutting assembly 54 back to its initial position. Then, the receiving assembly 52 is transferred to the encapsulation position, and the heat-sealing assembly 55 can be used to heat-seal the encapsulation film onto the first container.

[0074] By using the traction component 56 to move the clamping component 53 to move the cutting component 54, the cutting component 54 can move between the cutting position and the avoidance position, thereby avoiding interference between the cutting component 54 and the movement of the receiving component 52.

[0075] Combination Figure 9 As shown, the traction component includes a swing hook 561 and a second reset component. The swing hook 561 is swayably disposed on the clamping assembly 53, and the second reset component is disposed between the swing hook 561 and the clamping assembly 53. A first protrusion 18 is provided inside the frame 10, and a second protrusion 541 is provided on the cutting assembly 54. When the clamping assembly 53 moves toward the cutting assembly 54, the first protrusion 18 drives the swing hook 561 to swing, so that the swing hook 561 hooks onto the first protrusion 18. The second protrusion 541 can drive the swing hook 561 to swing, so that the swing hook 561 separates from the first protrusion 18. With the above design, when the clamping assembly 53 approaches the cutting assembly 54, the first protrusion 18 and the swing hook 561 interfere with each other, allowing the swing hook 561 to swing, thereby hooking onto the first protrusion 18. At this time, the clamping assembly 53 can drive the cutting assembly 54 to move toward the cutting position. After the cutting component 54 has finished cutting, the clamping component 53 continues to move, and the swing hook 561 can interfere with the second protrusion 541, thereby causing the swing hook 561 to separate from the first protrusion 18. At this time, the cutting component 54 returns to the avoidance position under the elastic force of the first reset member.

[0076] It should be noted that the first protrusion 18 and the second protrusion 541 are spaced apart along the second horizontal direction Y, and the swing hook 561 is located between the first protrusion 18 and the second protrusion 541.

[0077] Combination Figure 9As shown, a guide frame 19 is provided inside the frame 10. The swing hook 561 includes a guide block 5611 and a hook portion 5612. The guide block 5611 is guided and engaged with the guide frame 19, and the hook portion 5612 is swingably disposed on the guide block 5611. The second reset member includes a torsion spring, which is disposed between the guide block 5611 and the hook portion 5612. The clamping assembly 53 also includes a drive rod 535, on which a slide groove 5351 is provided. The slide groove 5351 extends along the second horizontal direction Y, and the hook portion 5612 is inserted into the slide groove 5351. When the clamping assembly 53 approaches the cutting assembly 54, the hook 5612 slides within the groove 5351, and the groove wall of the groove 5351 applies force to the hook 5612, allowing it to interfere with the first protrusion 18. This causes the swing hook 561 to hook onto the first protrusion 18, thereby moving the cutting assembly 54 toward the cutting position. After the cutting assembly 54 completes the cutting, the opposite side wall of the groove 5351 drives the hook 5612 to interfere with the second protrusion 541, causing the swing hook 561 to separate from the first protrusion 18.

[0078] Figure 6 A schematic diagram of the heat-sealing assembly of the high-throughput pipetting device provided in an embodiment of this application is shown. (Combined with...) Figure 6 As shown, the heat-sealing assembly 55 includes a fixed plate 551, a heating plate 552, and an elastic element 553. A pressure driving element is disposed on the fixed plate 551, and the elastic element 553 is located between the fixed plate 551 and the heating plate 552. The pressure driving element applies pressure to the fixed plate 551 and transmits the pressure to the heating plate 552 through the elastic element 553, thereby applying high temperature and high pressure to the heat-sealing film to seal it in the first container. The heat-sealing assembly 55 includes a suction cup 554 and a suction cup shaft 555. The suction cup shaft 555 is connected to the fixed plate 551, and the suction cup 554 is disposed on the suction cup shaft 555. The negative pressure provided by the suction cup 554 is used to adsorb the heat-sealing film.

[0079] Figure 7 A schematic diagram of the cutting component of the high-throughput pipetting device provided in an embodiment of this application is shown. (Combined with...) Figure 7As shown, the cutting assembly 54 includes a cutting frame 542, a cutting blade 543, and a third reset member 544. The cutting frame 542 is movably disposed, and a second protrusion 541 is disposed on the cutting frame 542. The cutting blade 543 is movably disposed on the cutting frame 542 in the vertical direction Z. The two ends of the third reset member 544 are respectively connected to the cutting frame 542 and the cutting blade 543. After the clamping assembly 53 moves the cutting frame 542 to the cutting position through the second protrusion 541, the heat sealing assembly 55 can apply pressure to the cutting blade 543, causing the cutting blade 543 to cut the heat sealing film. The suction cup 554 adsorbs the heat sealing film onto the first container, and the heat sealing film is heat-sealed into the first container under high temperature and high pressure. When the heat sealing assembly 55 moves away from the first container, the cutting blade 543 is reset by the action of the third reset member 544.

[0080] Figure 18 A partial schematic diagram of the stacking mechanism of the high-throughput pipetting device provided in Embodiment 1 of this application is shown. Figure 19 A cross-sectional view of the stack mechanism of the high-throughput pipetting device provided in Embodiment 1 of this application is shown. Figure 20 A front view of the stack mechanism of the high-throughput pipetting device provided in Embodiment 1 of this application is shown. (In conjunction with...) Figures 18 to 20 As shown, the high-throughput pipetting apparatus also includes a stacking mechanism 70, located on the side of the transport mechanism 80 away from the heat-sealing mechanism 50. The stacking mechanism 70 includes a transfer assembly 71 and a storage unit 72. The storage unit 72 stores a first container. The transfer assembly 71 is movably disposed within the frame 10 and can transfer the first container from the receiving assembly 52 to the storage unit 72. With this design, the first container is transferred from the receiving assembly 52 to the storage unit 72 via the transfer assembly 71 without manual intervention, automating the process and improving the efficiency of the high-throughput pipetting apparatus.

[0081] In this application, the conveying mechanism 80 is used to temporarily fix the first container and convey the first container after the liquid has been transferred. The liquid in the first container can be a sample or reagent, etc. Next, the first container is transferred by the conveying mechanism 80 to the receiving component 52, and then moved to the sealing position by the receiving component 52. A heat-sealing film is then applied to the first container using the heat-sealing component 55 to achieve heat sealing. The heat-sealed first container is then transferred to the storage container 72 for storage via the transfer component 71.

[0082] Figure 21 A schematic diagram of the lifting assembly of the high-throughput pipetting device provided in Embodiment 1 of this application is shown. (Combined with...) Figure 21As shown, in Embodiment 1, the stacking mechanism 70 further includes a lifting component 73. The storage component 72 extends vertically in the Z direction, and the lifting component 73 is located on the side of the transfer component 71 away from the storage component 72 in the Z direction. The transfer component 71 can move horizontally to transfer the first container from the first container placement position 11 to the transfer component 71. The lifting component 73 can move vertically in the Z direction to transfer the first container from the transfer component 71 to the storage component 72. With the above design, by moving the transfer component 71 horizontally, the first container can be transferred to the transfer component 71. Then, by moving the lifting component 73 vertically in the Z direction, the first container can be transferred to the storage component 72 using the lifting component 73. The structure is simple and reliable.

[0083] Combination Figure 21 As shown, in some embodiments, the lifting assembly 73 includes a lifting drive 731, a lifting seat 732, a lifting rod 733, and a lifting plate 734. The lifting seat 732 is fixedly installed, the lifting drive 731 is installed on the lifting seat 732, the lifting drive 731 is driven to connect with the lifting rod 733, thereby driving the lifting rod 733 to rotate. The lifting rod 733 and the lifting seat 732 are threadedly connected, so that when the lifting rod 733 rotates, it can move relative to the lifting seat 732 in the vertical direction Z. The lifting plate 734 is connected to the lifting rod 733, so that the lifting rod 733 can drive the lifting plate 734 to move in the vertical direction Z. The first container is placed on the lifting plate 734.

[0084] Among them, the lifting drive component 731 adopts a stepper motor.

[0085] Figure 19 A cross-sectional view of the stack mechanism of the high-throughput pipetting device provided in Embodiment 1 of this application is shown. (In conjunction with...) Figure 19 As shown, the stacking mechanism 70 also includes a support component 74, which is disposed on the storage unit 72. The support component 74 includes a support member 741, which is movably disposed on the storage unit 72 and has a limiting state and a clearance state. When the support member 741 is in the limiting state, it supports and cooperates with the first container. When the support member 741 is in the clearance state, it clears the first container, allowing the lifting component 73 to move the first container over the support member 741. With the above design, the lifting component 73 can move the first container vertically in the Z direction while keeping the support member 741 in the clearance state, allowing the first container to pass over the support member 741. By switching the support member 741 to the limiting state, it can limit the first container, allowing it to be stored in the storage unit 72.

[0086] In this embodiment, the first container is stacked vertically in the storage component 72 along the Z direction, with two adjacent first containers in contact with each other, and the bottommost first container is supported by the support component 741.

[0087] Combination Figure 19 As shown, the support assembly 74 also includes a support drive member 742, which is driven to connect with the support member 741, allowing the support member 741 to be swayably disposed on the storage member 72. The support assembly 74 also includes a connecting rod 743, with the support drive member 742 and the support member 741 located on opposite sides of the connecting rod 743. The support drive member 742 can drive the connecting rod 743 to sway swayably disposed on the storage member 72, and the connecting rod 743 can drive the support member 741 to sway. With this design, the support drive member 742 can drive one end of the connecting rod 743 to sway, thereby causing the other end of the connecting rod 743 to drive the support member 741 to sway, allowing the support member 741 to switch between a limited state and an avoidance state.

[0088] In some embodiments, the supporting drive member 742 includes an electromagnet and a push rod. The electromagnet is arranged vertically in the storage member 72 along the Z direction. When the electromagnet is energized, it can cause the push rod to move vertically in the Z direction. One end of the push rod is rotatably connected to the connecting rod 743. In order for the push rod to automatically reset, a spring is also sleeved on the push rod. When the push rod moves downward, it compresses the spring to store elastic potential energy, so that the push rod can automatically reset after the electromagnet is de-energized.

[0089] The stacking mechanism 70 includes multiple supporting components 74, which are arranged at intervals along the circumference of the storage component 72, so that the first container has more load-bearing points and the first container is more stable.

[0090] The transfer assembly includes a transfer frame and a transfer belt. The transfer belt is rotatably mounted on the transfer frame in a horizontal direction and is capable of transferring the first container to the storage unit 72. This design is simple and reliable.

[0091] Figure 31 A diagram showing the connection between the conveyor belt and the first transfer belt of the high-throughput pipetting apparatus provided in an embodiment of this application is shown. (In conjunction with...) Figure 31 As shown, one of the transfer belts and conveyor belts 82 is provided with a docking hole 87, and the other of the transfer belts and conveyor belts 82 is provided with a docking post 88. The docking hole 87 and the docking post 88 are inserted and mated together. By adopting the above design, the first container can move more smoothly during the transmission process by docking the transfer belts and conveyor belts 82.

[0092] Figure 22 A schematic diagram of the transfer component of the high-throughput pipetting device provided in Embodiment 1 of this application is shown. (Combined with...) Figure 22As shown, in Embodiment 1, the transfer frame includes a first transfer frame 711, the transfer belt includes two first transfer belts 712, and the storage unit 72 is disposed on the first transfer frame 711. The two first transfer belts 712 are respectively located on both sides of the lifting assembly 73 in the first horizontal direction X. The lifting assembly 73 can pass through the space between the two first transfer belts 712 in the vertical direction Z and move into the storage unit 72 to transfer the first container from the first transfer belts 712 to the storage unit 72. With the above design, by setting the first transfer belts 712 on both sides of the lifting assembly 73, the first container can be supported on both sides and the lifting assembly 73 can be avoided, allowing the lifting assembly 73 to pass through the space between the two first transfer belts 712. At the same time, when passing through the transfer assembly 71, it contacts the first container on the first transfer belt 712 and drives the first container to move towards the storage unit 72, thereby transferring the first container from the first transfer belt 712 to the storage unit 72.

[0093] In this process, the lifting rod 733 of the lifting assembly 73 drives the lifting plate 734 to move vertically in the Z direction. When the lifting plate 734 moves to the transfer assembly 71, it contacts the first container and moves the first container toward the storage unit 72. At this time, the support member 741 of the support assembly 74 is still in the limited position to support the first container in the storage unit 72. When the lifting plate 734 moves the first container to the support assembly 74, the support member 741 switches to the avoidance position, allowing the first container to pass over the support member 741. At this time, the support member 741 is switched back to the limited position, which can then support the first container that has just entered the storage unit 72.

[0094] In some embodiments, the first transfer belt 712 can simultaneously support two first containers along the first horizontal direction X, and the lifting plate 734 can simultaneously support two first containers. Furthermore, the stacking mechanism 70 includes two storage units 72, which are sequentially arranged along the first horizontal direction X, with each storage unit 72 corresponding to one of the two first containers supported by the lifting plate 734.

[0095] In Embodiment 1, the stacking mechanism 70 further includes a stacking support 77, located on one side of the frame 10. The stacking support 77 contains a control element capable of controlling the operating states of the transfer assembly 71 and the lifting assembly 73. The transfer assembly 71, the storage unit 72, and the lifting assembly 73 are mounted on the stacking support 77. This design allows for modular design of the high-throughput pipetting equipment, improving flexibility during use.

[0096] Figure 23 A schematic diagram of the stack mechanism of the high-throughput pipetting device provided in Embodiment 2 of this application is shown.

[0097] Figure 24This illustration shows another structural schematic diagram of the stacking mechanism of the high-throughput pipetting device provided in Embodiment 2 of this application. (Combined with...) Figure 23 and Figure 24 As shown, Embodiment 2 of this application provides a high-throughput pipetting device. The difference between Embodiment 2 and Embodiment 1 is that in Embodiment 2, the stacking mechanism 70 further includes a lifting component 75 and a rotating component 76. The lifting component 75 is movably disposed on the frame 10 along the vertical direction Z, the rotating component 76 is rotatably disposed on the lifting component 75 about an axis extending along the vertical direction Z, and the transfer component 71 is movably disposed on the rotating component 76 along the horizontal direction. With the above design, by moving the lifting component 75 along the vertical direction Z, the rotating component 76 and the transfer component 71 can be moved along the vertical direction Z. By rotating the rotating component 76, the transfer component 71 can be rotated. By moving the transfer component 71 along the horizontal direction, the transfer component 71 can move within space, thereby enabling the first container to be transferred from the first container placement position 11 to the storage component 72.

[0098] Figure 25 A schematic diagram of the lifting assembly of the high-throughput pipetting device provided in Embodiment 2 of this application is shown. (Combined with...) Figure 25 As shown, the lifting assembly 75 includes a lifting frame 751 and a lifting belt 752. The lifting belt 752 is rotatably mounted on the lifting frame 751 around the vertical direction Z. The lifting belt 752 is driven to connect with the rotating assembly 76 to drive the rotating assembly 76 to move along the vertical direction Z. By rotating the lifting belt 752 around the vertical direction Z, the rotating assembly 76 is driven to move along the vertical direction Z, resulting in a simple and reliable structure.

[0099] The lifting assembly 75 further includes a lifting drive, a driving wheel, a driven wheel, a linear guide rail, and a lifting plate. A lifting belt 752 is wound around the driving wheel and the driven wheel. The lifting drive is connected to the driving wheel to rotate it. The lifting plate is connected to the lifting belt 752 and is guided by the linear guide rail.

[0100] Figure 26 This illustration shows another structural schematic diagram of the lifting assembly of the high-throughput pipetting device provided in Embodiment 2 of this application. Combined with... Figure 26 As shown, the lifting assembly 75 also includes a counterweight rope 753 and a counterweight 754. The counterweight 754 and the rotating assembly 76 are located on both sides of the lifting frame 751, and the two ends of the counterweight rope 753 are connected to the counterweight 754 and the rotating assembly 76, respectively. With the above design, by connecting the two ends of the counterweight rope 753 to the counterweight 754 and the rotating assembly 76, the rotating assembly 76 can be suspended in a suitable position by external force when the lifting drive is de-energized, preventing it from slipping.

[0101] Figure 27A schematic diagram of the rotating assembly of the high-throughput pipetting device provided in Embodiment 2 of this application is shown. (Combined with...) Figure 27 As shown, the rotating assembly 76 includes a rotating frame 761 and a rotating wheel 762. The rotating frame 761 is disposed on the lifting assembly 75, and the rotating wheel 762 is rotatably disposed on the rotating frame 761 about an axis extending in the vertical direction Z. The transfer assembly 71 is disposed on the rotating wheel 762. With the above design, the rotating wheel 762 can drive the transfer assembly 71 to rotate in the horizontal plane, thereby adjusting the direction of the transfer assembly 71.

[0102] The rotating assembly 76 further includes a rotating drive component and a drive wheel. The drive wheel is sleeved on the rotating drive component, which is mounted on the rotating frame 761. The drive wheel and the rotating wheel 762 are connected by a transmission connection to cause the rotating wheel 762 to rotate. The rotating frame 761 is connected to the lifting plate.

[0103] Figure 28 A schematic diagram of the transfer component of the high-throughput pipetting device provided in Embodiment 2 of this application is shown. (Combined with...) Figure 28 As shown, the transfer frame includes a second transfer frame 713, the transfer belt includes a second transfer belt 714, and the transfer assembly 71 also includes a tray 715. The second transfer frame 713 is disposed on the rotating assembly 76, the second transfer belt 714 is rotatably disposed on the second transfer frame 713 in a horizontal direction, and the tray 715 is disposed on the second transfer belt 714. The second transfer belt 714 can drive the tray 715 to move in a horizontal direction. With the above design, by moving the second transfer belt 714 in a horizontal direction, the tray 715 can be driven to move in a horizontal direction, thereby enabling the first container to be transported from the tray 715 to the storage unit 72.

[0104] In Embodiment 2, the storage unit 72 is provided with multiple storage positions, which are arranged at intervals along the vertical direction Z. The lifting component 75 can move the tray 715 along the vertical direction Z to different height positions, thereby corresponding to storage positions of different heights. The rotating component 76 can move the tray 715 toward the corresponding storage position, and the transfer component 71 can move the tray 715 horizontally to the corresponding storage position.

[0105] The technical features of the embodiments described above can be combined arbitrarily. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as the combination of these technical features does not contradict each other, it should be considered within the scope of this specification. The embodiments described above only illustrate several implementation methods of this application, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of the patent application.

Claims

1. A high-throughput pipetting apparatus, characterized in that, The high-throughput pipetting device comprises: a rack; a pipetting mechanism comprising a pipetting needle movably arranged in the rack; a conveying mechanism comprising a conveying member and a limiting member, the conveying member is movably arranged in the rack along a first horizontal direction; the conveying member is provided with a first container placement position, the rack is provided with a second container placement position; the pipetting needle can be moved above the first container placement position and the second container placement position respectively; the limiting member is movably arranged in the rack and has an initial state and a limiting state; when the limiting member is in the initial state, the limiting member avoids the first container, and the conveying member drives the first container to move through a preset position; when the limiting member is in the limiting state, the limiting member is limitedly matched with the first container at the preset position.

2. The high-throughput pipetting apparatus of claim 1, wherein, The high-throughput pipetting device further comprises a heat sealing mechanism, the heat sealing mechanism comprises a feeding assembly and a sealing assembly, the feeding assembly is used for conveying a heat sealing film to the sealing assembly, and the sealing assembly is used for heat sealing the heat sealing film to the first container.

3. The high throughput pipetting apparatus of claim 2, wherein, The heat sealing mechanism further comprises a receiving assembly movably arranged in the rack; the receiving assembly has a receiving position corresponding to the conveying member and a sealing position corresponding to the sealing assembly; when the receiving assembly moves to the receiving position, the first container can be transferred from the conveying member to the receiving assembly; when the receiving assembly moves to the sealing position, the sealing assembly heat seals the heat sealing film to the first container.

4. The high throughput pipetting apparatus of claim 3, wherein, The high-throughput pipetting device further comprises a stacking mechanism located on a side of the conveying mechanism away from the heat sealing mechanism; the stacking mechanism comprises a transfer assembly and a storage member for storing the first container, and the transfer assembly is movably arranged in the rack; the transfer assembly can transfer the first container from the receiving assembly to the storage member.

5. The high-throughput pipetting apparatus of claim 4, wherein, The stacking mechanism further comprises a jacking assembly, the storage member extends along a vertical direction, and the jacking assembly is located on a side of the transfer assembly away from the storage member along the vertical direction; the transfer assembly can move along a horizontal direction to transfer the first container from the receiving assembly to the transfer assembly; and the jacking assembly can move along the vertical direction to transfer the first container from the transfer assembly to the storage member.

6. The high-throughput pipetting apparatus of claim 5, wherein, The stacking mechanism further comprises a supporting assembly arranged on the storage member, the supporting assembly comprises a supporting member movably arranged on the storage member and having a limiting state and an avoiding state; when the supporting member is in the limiting state, the supporting member is supported with the first container; and when the supporting member is in the avoiding state, the supporting member avoids the first container, so that the jacking assembly can drive the first container to pass through the supporting member.

7. The high throughput pipetting apparatus of claim 4, wherein, The stacking mechanism further comprises a lifting assembly movably arranged in the vertical direction on the rack and a rotating assembly rotatably arranged on the lifting assembly about an axis extending in the vertical direction, and the transfer assembly is movably arranged on the rotating assembly in the horizontal direction.

8. The high throughput pipetting apparatus of claim 4, wherein, The transfer assembly comprises a transfer frame and a transfer belt rotatably arranged on the transfer frame in the horizontal direction, and the transfer belt is capable of transferring the first container to the storage element; one of the transfer belt and the conveying element is provided with a docking hole, and the other of the transfer belt and the conveying element is provided with a docking column, and the docking hole and the docking column are inserted and matched.

9. The high throughput pipetting apparatus of claim 3, wherein, The packaging assembly comprises a clamping assembly, a cutting assembly and a heat sealing assembly, the clamping assembly, the receiving assembly, the cutting assembly and the feeding assembly are arranged in a second horizontal direction when the receiving assembly moves to the packaging position, and the heat sealing assembly is arranged above the receiving assembly in the vertical direction; the clamping assembly is used for clamping the heat sealing film, so that the heat sealing film passes through the cutting assembly and the packaging position in sequence from the feeding assembly; the heat sealing assembly is capable of moving in the vertical direction to heat seal the heat sealing film to the first container located in the receiving assembly.

10. The high-throughput pipetting apparatus of claim 9, wherein, The heat sealing mechanism further comprises a traction assembly, the traction assembly comprises a traction element and a first reset element, the traction element is arranged on the clamping assembly, the clamping assembly is capable of moving in the second horizontal direction to drive the cutting assembly to move to a cutting position through the traction element; the first reset element is connected with the cutting assembly and the rack respectively, so that the cutting assembly moves to a avoiding position.

11. The high-throughput pipetting apparatus of claim 10, wherein, The traction element comprises a swing hook and a second reset element, the swing hook is swingably arranged on the clamping assembly, and the second reset element is arranged between the swing hook and the clamping assembly; a first protrusion is arranged in the rack, and a second protrusion is arranged on the cutting assembly, when the clamping assembly moves towards the cutting assembly, the first protrusion drives the swing hook to swing, so that the swing hook is hooked on the first protrusion; the second protrusion is capable of driving the swing hook to swing, so that the swing hook is separated from the first protrusion.

12. The high-throughput pipetting apparatus of claim 1, wherein, The limiting element comprises a first clamping element and a second clamping element, the first clamping element and the second clamping element are arranged in the first horizontal direction, and the first clamping element and the second clamping element are capable of switching between the initial state and the limiting state; when the limiting element is switched from the initial state to the limiting state, the first clamping element and the second clamping element are capable of limiting and matching with the opposite sides of the first container respectively.

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