Biocompatible polymer material, preparation method and application thereof

Abstract

The invention relates to the technical field of polymer materials, and particularly provides a biocompatible polymer material as well as a preparation method and application thereof. The molecular structure of the biocompatible polymer material contains at least one first block and at least one second block, the first blocks and the second blocks are arranged alternately, and the adjacent first blocks and second blocks are connected through carbamate bonds; the first block is formed by aliphatic polyester diol and / or alicyclic polyester diol, and the number-average molecular weight of the first block is 1000-10000; the second block is formed by aliphatic polyether glycol, and the number-average molecular weight of the second block is 200-2000. The polyurethane material disclosed by the invention has the characteristic of relatively high mechanical strength, and the cytotoxicity of the polyurethane material is relatively low after the low-molecular-weight monohydric alcohol is further adopted for blocking. The polyurethane material can be used for biological tissue engineering or wound dressing.

Description

Technical Field

[0001] This application relates to the field of polyurethane materials technology, specifically to a biocompatible polymer material, its preparation method, and its application. Background Technology

[0002] Polyurethane materials possess good biocompatibility and are widely used in medical products. By employing biodegradable polyester diols, such as polylactide diol (PCL), polylactic acid diol (PLA), and polyglycolic acid diol (PGA), the biodegradability of polyurethane materials can be further enhanced. Polyurethane neural scaffolds are tissue-engineered products made from polyurethane and are used to repair and regenerate peripheral nerves.

[0003] Researchers have found that the structure and preparation method of polyurethane have a significant impact on the performance of polyurethane neural scaffolds, especially their mechanical properties and biocompatibility. Therefore, it is necessary to carefully analyze and study the structural design and preparation methods of polyurethane to further improve the mechanical properties and biocompatibility of polyurethane materials. Summary of the Invention

[0004] In order to solve the above-mentioned technical problems, the inventors conducted in-depth research on the structural design and preparation method of polyurethane, and discovered polyurethane materials and preparation methods with high mechanical properties and good biocompatibility. Therefore, this application is hereby filed.

[0005] The technical solution adopted in this application is as follows: A biocompatible polymer material, wherein the molecular structure of the polymer material contains at least one first block and at least one second block, the first block and the second block are arranged alternately, and adjacent first blocks and second blocks are connected by urethane bonds; The first block is formed of an aliphatic polyester diol and / or an alicyclic polyester diol; the number average molecular weight of the aliphatic polyester diol and / or the alicyclic polyester diol is 1000-10000; The second block is formed from an aliphatic polyether diol; the number average molecular weight of the aliphatic polyether diol is 200-2000.

[0006] Preferably, the aliphatic polyester diol is selected from one or a combination of several of polyethylene glycol diol, polylactide diol, polybutylene succinate diol, and polycaprolactone diol.

[0007] Preferably, the alicyclic polyester diol is selected from polymers of C5-C12 cycloalkyl diols with succinic acid and / or adipic acid.

[0008] Preferably, the first block is composed of aliphatic polyester diol and alicyclic polyester diol in a molar ratio of 1:0.05-1.5.

[0009] Preferably, the aliphatic polyether diol is selected from polyethylene glycol.

[0010] Preferably, the polyurethane material uses a monohydric alcohol as a capping agent, and the general formula of the monohydric alcohol is C0. n H 2n+1 OH, n = 1-6.

[0011] A method for preparing a biocompatible polymer material according to any of the above embodiments, comprising: The polyether diol and diisocyanate monomer undergo a first reaction at a molar ratio of 0.5-0.9:1 to obtain a first polyurethane prepolymer; the first polyurethane prepolymer undergoes a second reaction with the aliphatic polyester diol and / or alicyclic polyester diol at a molar ratio of -NCO and -OH groups of 0.98-1.1:1 to obtain the final product. or, The aliphatic polyester diol and / or alicyclic polyester diol are reacted with diisocyanate monomers in a third reaction at a molar ratio of 0.5-0.9:1 to obtain a second polyurethane prepolymer; The second polyurethane prepolymer and the polyether diol are reacted for the fourth time at a molar ratio of -NCO and -OH groups of 0.98-1.1:1 to obtain the final product.

[0012] Preferably, after the second and / or fourth reaction, a monohydric alcohol is added for end-capping, the monohydric alcohol having the general formula C0. n H 2n+1 OH, n = 1-6.

[0013] More preferably, the number of moles of the monohydric alcohol is 10-50% of the number of moles of NCO in the first polyurethane prepolymer or the second polyurethane prepolymer.

[0014] An application of the biocompatible polymer material described in any of the above embodiments, in biotissue engineering or wound dressings.

[0015] In summary, this application has at least the following beneficial effects: 1. The inventors discovered that the number-average molecular weight of aliphatic polyester diols, alicyclic polyester diols, and polyether diols has a significant impact on the mechanical properties of polyurethane materials. Both excessively high and low number-average molecular weights are detrimental to improving the mechanical properties of polyurethane materials.

[0016] 2. The inventors further discovered that using a small-molecule monohydric alcohol as a capping agent can significantly reduce the cytotoxicity of polyurethane materials and further improve the safety of polyurethane materials in medical products. Detailed Implementation

[0017] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be described in detail below.

[0018] Throughout this specification, unless otherwise specified, the terminology used herein should be understood as having the meaning commonly used in the art. Therefore, unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. In the event of any conflict, this specification shall prevail.

[0019] This application proposes a biocompatible polymer material, wherein the molecular structure of the polymer material contains at least one first block and at least one second block, the first block and the second block are arranged alternately, and adjacent first blocks and second blocks are connected by urethane bonds; The first block is formed from aliphatic polyester diols and / or alicyclic polyester diols, such as a single aliphatic polyester and / or alicyclic polyester segment, or a segment formed by the reaction of aliphatic and / or alicyclic polyester with isocyanate; the number average molecular weight of the aliphatic polyester diol and / or alicyclic polyester diol is 1000-10000. The second block is formed from an aliphatic polyether diol, such as a single aliphatic polyether or a segment formed by the reaction of an aliphatic polyether with an isocyanate; the number average molecular weight of the aliphatic polyether diol is 200-2000. For example, the aliphatic polyether diol can be polyethylene glycol.

[0020] The inventors discovered that polyurethanes with aliphatic polyester diols, alicyclic polyester diols, and aliphatic polyether diols within the aforementioned number-average molecular weight range exhibit better mechanical strength. The reason for this may be that, given the same raw materials, the mechanical strength of polyurethane within a certain range is related to the distribution, density, and physical crosslinking structure of its soft and hard segments. Within a certain range, a higher hard segment density results in higher mechanical strength; however, excessively high hard segment density leads to brittleness and a decrease in mechanical strength. By selecting aliphatic polyester diols, alicyclic polyester diols, and aliphatic polyether diols within the aforementioned number-average molecular weight range, the polyurethane exhibits a more balanced distribution of soft and hard segments, stronger interactions between soft and hard segments and between polyester and polyether, and the density and distribution of the physical crosslinking structure formed by hydrogen bonding between urethane bonds and between urethane bonds and ester and / or ether bonds are also within a reasonable range, resulting in higher mechanical strength of the polyurethane. Preferably, the number average molecular weight of aliphatic polyester diols and / or alicyclic polyester diols is 3 to 6 times that of aliphatic polyether diols, for example, it can be 3 times, 3.5 times, 4 times, 4.5 times, 5 times, 5.5 times, 6 times, etc.

[0021] In this application, the number-average molecular weight of aliphatic polyester diols, alicyclic polyester diols, and aliphatic polyether diols can be tested using gel permeation chromatography (GPC), and the mobile phase can be tetrahydrofuran. For example, the number-average molecular weight of aliphatic polyester diols and / or alicyclic polyester diols can be 1000, 2000, 2500, 3000, 3500, 4000, 4500, 5000, 5500, 6000, 7000, 8000, 9000, 10000, etc.; and the number-average molecular weight of aliphatic polyether diols can be 200, 400, 600, 800, 1000, 1200, 1500, 1800, 2000, etc. More preferably, the number average molecular weight of aliphatic polyester diols and / or alicyclic polyester diols is 2000-10000, and the number average molecular weight of aliphatic polyether diols is 400-2000.

[0022] In a preferred embodiment of this application, the aliphatic polyester diol is a biodegradable aliphatic polyester diol, which can be selected from one or a combination of several of polyglycolic acid diol (PGA), polylactide diol (PLA), polybutylene succinate diol (PBS), and polycaprolactone diol (PCL), or it can be polybutylene adipate succinate (PBSA), PBAT, etc. Using the above-mentioned aliphatic polyester diols provides both good biocompatibility and biodegradability, thus broadening the performance range of polyurethane materials.

[0023] In a preferred embodiment of this application, the alicyclic polyester diol is selected from polymers of C5-C12 cycloalkyl diols with succinic acid and / or adipic acid, or polymers of C5-C12 cycloalkyl dicarboxylic acids with butanediol and / or hexanediol. The presence of cycloalkyl groups in the alicyclic polyester diol can further improve the rigidity of the polyurethane polymer chain, thereby increasing the mechanical strength of the polyurethane material. For example, the cycloalkyl diol can be selected from 1,3-cyclopentanediol, 1,4-cyclohexanediol, 1,2-cyclohexanediol, 1,2-cyclohexanediethanol, 1,4-cyclohexanediethanol, etc., and can be one or a combination of two or more of these. The cycloalkyl dicarboxylic acid can be selected from 1,3-cyclohexanedicarboxylic acid, 1,4-cyclohexanedicarboxylic acid, etc.

[0024] In a preferred embodiment of this application, the first block is composed of an aliphatic polyester diol and an alicyclic polyester diol in a molar ratio of 1:0.05-1.5. The combination of the aliphatic and alicyclic polyester diols in the above molar ratio in the first block can combine the flexibility of the aliphatic polyester diol with the rigidity of the alicyclic polyester diol. More preferably, the first block is composed of an aliphatic polyester diol and an alicyclic polyester diol in a molar ratio of 1:0.2-1.2. For example, the molar ratio can be 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:1.1, 1:1.2, etc.

[0025] In a preferred embodiment of this application, the polyurethane material uses a monohydric alcohol as a capping agent, and the general formula of the monohydric alcohol is C0. n H 2n+1 OH, n = 1-6. This application uses a monohydric alcohol as a capping agent, which has been found to further reduce the biotoxicity or cytotoxicity of polyurethane materials. This is likely because isocyanates are highly biotoxic; even if the residual isocyanate at the ends of the polyurethane is very low, it can still have a certain toxic effect on cells or biological tissues. Using a monohydric alcohol as a capping agent, with its low molecular weight and high hydroxyl activity, not only can residual isocyanate groups be reacted away, but the capping end groups are also inert alkyl groups, exhibiting virtually no biotoxicity or cytotoxicity. More preferably, the monohydric alcohol is selected from methanol, ethanol, or isopropanol.

[0026] Another aspect of this application provides a method for preparing the biocompatible polymer material described in any of the above embodiments, comprising: The first polyurethane prepolymer is obtained by reacting polyether diol and diisocyanate monomer in a molar ratio of 0.5-0.9:1. The first polyurethane prepolymer is reacted with an aliphatic polyester diol and / or an alicyclic polyester diol in a molar ratio of -NCO and -OH groups of 0.98-1.1:1 to obtain the final product. or, A third reaction is carried out with aliphatic polyester diols and / or alicyclic polyester diols and diisocyanate monomers at a molar ratio of 0.5-0.9:1 to obtain a second polyurethane prepolymer; The second polyurethane prepolymer and polyether diol are reacted for the fourth time at a molar ratio of -NCO and -OH groups of 0.98-1.1:1 to obtain the final product.

[0027] In the above preparation method, there are no particular restrictions on the diisocyanate monomer, which can be selected from isophorone diisocyanate IPDI, toluene diisocyanate TDI, diphenylmethane diisocyanate MDI, hexamethylene diisocyanate HMDI, dicyclohexylmethane diisocyanate H12MDI, 1,5-naphthalene diisocyanate NDI, etc.

[0028] In this application, the polyurethane prepolymer may be obtained by first reacting an aliphatic polyether diol with a diisocyanate monomer, and then reacted with an aliphatic polyester diol and / or an alicyclic polyester diol; or the polyurethane prepolymer may be obtained by first reacting an aliphatic polyester diol and / or an alicyclic polyester diol with a diisocyanate monomer, and then reacted with an aliphatic polyether diol.

[0029] In this application, preferably, the molar ratio of polyether diol to diisocyanate monomer is 0.6-0.75:1, and the molar ratio of aliphatic polyester diol and / or alicyclic polyester diol to diisocyanate monomer is 0.75-0.85:1, which can make the soft and hard segments in the polyurethane material more balanced and the mechanical properties of the polyurethane material higher.

[0030] In a preferred embodiment of this application, after the second and / or fourth reaction, a monohydric alcohol is added for a capping reaction. The general formula of the monohydric alcohol is C0. n H 2n+1 OH, n = 1-6.

[0031] The inventors discovered that during the second and fourth reactions, regardless of whether the polyurethane prepolymer was in excess or insufficient, isocyanate groups remained after the reaction. This may be due to the low reactivity of isocyanates at the ends of the macromolecules, making complete reaction difficult, or the isocyanate end groups being surrounded by polymer chains and unable to effectively participate in the reaction. When the polyurethane prepolymer was in excess, isocyanate groups were definitely present, and these residual isocyanates were highly toxic to cells. When the polyurethane prepolymer was insufficient, as the reaction proceeded, the isocyanates and hydroxyl groups at the ends of the macromolecules had low reactivity, making complete reaction difficult and leaving a small amount of isocyanate groups remaining. The inventors found that by adding a monohydric alcohol for end-capping, the high reactivity of the small molecule monohydric alcohol allowed it to react with the remaining or residual isocyanate groups, or to penetrate between polymer chains before contacting and reacting with the isocyanate groups. This resulted in the isocyanates being reacted almost completely, leaving very little or no residue, further reducing the cytotoxicity of the polyurethane material.

[0032] In a more preferred embodiment of this application, the molar number of the monohydric alcohol is 10-50% of the molar number of NCO in the first or second polyurethane prepolymer. Adding the monohydric alcohol within this range ensures complete reaction of the NCO groups, and excess unreacted monohydric alcohol can be removed by methods such as vacuum reduction or atmospheric pressure heating and drying. More preferably, the molar number of the monohydric alcohol is 20-50% of the molar number of NCO in the first or second polyurethane prepolymer.

[0033] After the reaction preparation is completed, the polyurethane material of this application can be dissolved in an organic solvent, such as ethyl acetate, acetone, butyl acetate, etc., to prepare a solution with a concentration of 10-40 wt%. Then, it is added to methanol at multiple volumes (e.g., 12, 15, 20 times) of the solution for precipitation. After collecting the precipitate, it is dried to obtain the polyurethane material.

[0034] In another aspect, this application proposes an application of the biocompatible polymer material described in any of the above embodiments in biotissue engineering or wound dressings, such as neural scaffolds.

[0035] The technical solution of this application will be described in detail below with reference to embodiments and comparative examples.

[0036] Example 1 Under nitrogen protection, PEG600 (600 represents number-average molecular weight) and IPDI were added to the reaction vessel at a molar ratio of 0.7:1. PEG600 and IPDI by weight and 0.15% dibutyltin dilaurate were added. The mixture was stirred at room temperature for 1 hour, and then heated to 70-75℃ for 2 hours to obtain the polyurethane prepolymer.

[0037] The above-mentioned polyurethane prepolymer and PCL (number average molecular weight 2900) were mixed at a molar ratio of NCO groups to OH groups of 0.98:1. Under nitrogen protection, the mixture was heated to 80-85℃ and reacted for 5 hours. After cooling, ethyl acetate was added to prepare a 20wt% solution. The solution was then added to 20 times its volume of methanol to precipitate the polyurethane material. The precipitate was collected and dried overnight in an oven at 50℃ to obtain the polyurethane material.

[0038] Example 2 The difference between Example 2 and Example 1 is as follows: In Example 1, after heating to 80-85℃ and reacting for 5 hours, but before cooling down, anhydrous ethanol of 30% of the molar amount of NCO in the polyurethane prepolymer was added, and the mixture was stirred at a constant temperature for 2 hours. The remaining steps remained unchanged.

[0039] Example 3 The difference between Example 2 and Example 1 is that in Example 1, the polyurethane prepolymer and PCL were mixed at a molar ratio of NCO groups to OH groups of 1:1.05. The remaining steps remained unchanged.

[0040] Example 4 The difference between Example 4 and Example 3 is as follows: In Example 3, after heating to 80-85℃ and reacting for 5 hours, but before cooling down, isopropanol of 30% of the NCO molar amount in the polyurethane prepolymer is added, and the mixture is stirred at a constant temperature for 2 hours. The remaining steps remain unchanged.

[0041] Example 5 The difference between Example 5 and Example 1 is that in Example 1, PCL is replaced with an equimolar combination of PCL (the same as in Example 1) and poly(1,4-cyclohexanediol) diol (number average molecular weight 3400) in a molar ratio of 1:0.4. The remaining steps remain unchanged.

[0042] Example 6 The difference between Example 6 and Example 5 is that the molar ratio of PCL and poly(1,4-cyclohexanediol) diol in Example 5 was adjusted from 1:0.4 to 1:0.9. The remaining steps remained unchanged.

[0043] Example 7 The difference between Example 7 and Example 5 is that the molar ratio of PCL and poly(1,4-cyclohexanediol) diol in Example 5 was adjusted from 1:0.4 to 1:1.2. The remaining steps remained unchanged.

[0044] Example 8 The difference between Example 8 and Example 1 is that the molar ratio of PEG600 and IPDI is adjusted from 0.7:1 to 0.62:1, while the other steps remain unchanged.

[0045] Example 9 The difference between Example 9 and Example 1 is that the molar ratio of PEG600 and IPDI is adjusted from 0.7:1 to 0.75:1, while the other steps remain unchanged.

[0046] Example 10 The difference between Example 10 and Example 1 is that the number-average molecular weight of PEG was adjusted from 600 to 1000. The remaining steps remain unchanged.

[0047] Example 11 The difference between Example 11 and Example 1 is that the number-average molecular weight of PEG was adjusted from 600 to 1500. The remaining steps remain unchanged.

[0048] Example 12 The difference between Example 12 and Example 11 is that the number-average molecular weight of PCL was adjusted from 2900 to 4500. The remaining steps remain unchanged.

[0049] Example 13 The difference between Example 13 and Example 11 is that the number-average molecular weight of PCL was adjusted from 2900 to 7400. The remaining steps remain unchanged.

[0050] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that the number-average molecular weight of PEG was adjusted from 600 to 250. The remaining steps remained unchanged.

[0051] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that the number-average molecular weight of PEG was adjusted from 600 to 2300. The remaining steps remained unchanged.

[0052] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that the number-average molecular weight of PCL was adjusted from 2900 to 1700. The remaining steps remained unchanged.

[0053] Comparative Example 4 The difference between Comparative Example 4 and Example 1 is that the number-average molecular weight of PCL was adjusted from 2900 to 12500. The remaining steps remained unchanged.

[0054] Comparative Example 5 The difference between Comparative Example 5 and Example 2 is that anhydrous ethanol was replaced with an equimolar amount of ethylenediamine. The remaining steps remained unchanged.

[0055] Comparative Example 6 The difference between Comparative Example 6 and Comparative Example 5 is that the number of moles of ethylenediamine is reduced by half. The remaining steps remain unchanged.

[0056] Example 14 Under nitrogen protection, PLA (number average molecular weight 6000), PCL (number average molecular weight 4500) and IPDI were added to a reaction vessel in a molar ratio of 0.1:0.7:1. The weights of PLA, PCL and IPDI and 0.15% dibutyltin dilaurate were added. The mixture was stirred at room temperature for 1 hour, and then heated to 70-75℃ for 3 hours to obtain a polyurethane prepolymer.

[0057] The above-mentioned polyurethane prepolymer and PEG (number average molecular weight 1200) were mixed at a molar ratio of NCO groups to OH groups of 0.99:1. Under nitrogen protection, the mixture was heated to 80-85℃ and reacted for 5 hours. Methanol, which accounted for 20% of the NCO molars in the polyurethane prepolymer, was added, and the reaction was continued at a constant temperature for 2 hours. The mixture was then cooled, and acetone was added to prepare a 25wt% solution. The solution was then added to 20 times its volume of methanol to precipitate the precipitate. The precipitate was collected and dried overnight in an oven at 50℃ to obtain the polyurethane material.

[0058] Example 15 The difference between Example 15 and Example 14 is that the molar ratio of PLA, PCL, and IPDI is adjusted from 0.1:0.7:1 to 0.06:0.4:1. The remaining steps remain unchanged.

[0059] Example 16 The difference between Example 16 and Example 14 is that the molar ratio of PLA, PCL, and IPDI is adjusted from 0.1:0.7:1 to 0.12:0.84:1. The remaining steps remain unchanged.

[0060] Example 17 The difference between Example 17 and Example 14 is that the number-average molecular weight of PEG was adjusted from 1200 to 600, while the other steps remained unchanged.

[0061] Comparative Example 7 The difference between Comparative Example 7 and Example 14 is that the number-average molecular weight of PEG was adjusted from 1200 to 2400, while the other steps remained unchanged.

[0062] The polyurethane materials of Examples 1-17 and Comparative Examples 1-7 were made into thin films, and the following properties were tested.

[0063] Tensile strength: Tested according to GB / T 528-2009.

[0064] Cytotoxicity: The direct contact method according to ISO 10993-5 was used to test the cell line L929. The survival rate of normal cells was observed and calculated.

[0065] The results are shown in Table 1 below.

[0066] Table 1 As shown in Table 1, the polyurethane material of this application exhibits good mechanical properties. When the number-average molecular weight difference between aliphatic polyester diols and aliphatic polyether diols is too small or too large, it negatively impacts the tensile strength of the polyurethane material. Furthermore, the distribution density of aliphatic polyester diols within the polyurethane material structure also affects tensile strength; a suitable distribution density of aliphatic polyester segments is necessary to obtain a polyurethane material with high tensile strength. Moreover, end-capping with low-molecular-weight monohydric alcohols such as methanol and ethanol after the polyurethane material reaction significantly reduces its toxic effects on cells, resulting in better biocompatibility.

[0067] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A biocompatible polymer material, characterized in that, The polymer material contains at least one first block and at least one second block in its molecular structure, the first block and the second block are arranged alternately, and adjacent first blocks and second blocks are connected by urethane bonds; The first block is formed of an aliphatic polyester diol and / or an alicyclic polyester diol; the number average molecular weight of the aliphatic polyester diol and / or the alicyclic polyester diol is 1000-10000; The second block is formed from an aliphatic polyether diol; the number average molecular weight of the aliphatic polyether diol is 200-2000.

2. The biocompatible polymer material according to claim 1, characterized in that, The aliphatic polyester diol is selected from one or a combination of several of the following: polyglycolic acid diol, polylactide diol, polybutylene succinate diol, and polycaprolactone diol.

3. The biocompatible polymer material according to claim 1, characterized in that, The alicyclic polyester diol is selected from polymers of C5-C12 cycloalkyl diols with succinic acid and / or adipic acid.

4. The biocompatible polymer material according to claim 1, characterized in that, The first block is composed of aliphatic polyester diol and alicyclic polyester diol in a molar ratio of 1:0.05-1.

5.

5. The biocompatible polymer material according to claim 1, characterized in that, The aliphatic polyether diol is selected from polyethylene glycol.

6. The biocompatible polymer material according to claim 1, characterized in that, The polyurethane material uses a monohydric alcohol as a capping agent, and the general formula of the monohydric alcohol is C0. n H 2n+1 OH, n=1-6.

7. A method for preparing a biocompatible polymer material according to any one of claims 1-5, characterized in that, include: The polyether diol and diisocyanate monomer are reacted in a molar ratio of 0.5-0.9:1 to obtain the first polyurethane prepolymer. The first polyurethane prepolymer is reacted with the aliphatic polyester diol and / or alicyclic polyester diol in a molar ratio of -NCO and -OH groups of 0.98-1.1:1 to obtain the product. or, The aliphatic polyester diol and / or alicyclic polyester diol are reacted with diisocyanate monomers in a third reaction at a molar ratio of 0.5-0.9:1 to obtain a second polyurethane prepolymer; The second polyurethane prepolymer and the polyether diol are reacted for the fourth time at a molar ratio of -NCO and -OH groups of 0.98-1.1:1 to obtain the final product.

8. The method for preparing the biocompatible polymer material according to claim 7, characterized in that, Following the second and / or fourth reaction, a monohydric alcohol is added for end-capping, wherein the monohydric alcohol has the general formula C0. n H 2n+1 OH, n=1-6.

9. The method for preparing the biocompatible polymer material according to claim 8, characterized in that, The number of moles of the monohydric alcohol is 10-50% of the number of moles of NCO in the first polyurethane prepolymer or the second polyurethane prepolymer.

10. The application of a biocompatible polymer material according to any one of claims 1-6, characterized in that, It is used in biological tissue engineering or wound dressings.

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