Lipid-lowering weight-losing composition and application thereof

Abstract

The invention relates to the technical field of health-care products, and aims to provide a lipid-lowering and weight-losing composition which comprises the following components in parts by mass: 10-15 parts of chitosan, 20-35 parts of a tea bean extract, 5-10 parts of a pawpaw extract, 2-8 parts of a Chinese wolfberry extract, 2-10 parts of an immature bitter orange extract, 5-10 parts of a nomame senna extract, 2-6 parts of composite biomass and 5-10 parts of dietary fibers. By reasonably selecting various components with different fat-reducing and weight-losing mechanisms, controlling the dosage of the components and scientifically matching the components, the obtained composition has the advantages of good effect and quick response, and does not generate dependence.

Description

Technical Field

[0001] This invention relates to the field of health product technology, and more specifically, to a lipid-lowering and weight-loss composition. Background Technology

[0002] Obesity refers to a significant degree of overweight and excessive fat accumulation, a condition caused by excessive accumulation of body fat, especially triglycerides. Excessive food intake or changes in metabolism lead to excessive fat accumulation, resulting in excessive weight gain and causing or inducing pathological and physiological changes in the body.

[0003] In current technologies, the main treatments for hyperglycemia and hyperlipidemia are Western medicine and surgery, with some traditional Chinese medicines also becoming routine medications for these diseases. However, these methods often involve strong dependence, significant side effects, and high risks. On the other hand, many patients have a psychological aversion to drug preparations, leading to voluntary discontinuation of medication and adverse reactions after taking the drugs.

[0004] Chinese patent CN106822097B discloses a pharmaceutical composition containing orlistat for weight loss, which contains orlistat and oligosaccharides. This invention reduces gastrointestinal side effects while maintaining the weight loss efficacy of currently commercially available orlistat products; however, long-term use of chemical drugs can lead to dependence.

[0005] Chinese patent CN106562144A discloses a fat-reducing and antioxidant fermented yogurt, pecan juice, made from the following ingredients by weight: pecan kernels, pectinase, cellulase, alkaline protease, citrus essential oil, fresh milk, sucrose, Streptococcus thermophilus… oat extract, cassia seeds, winter melon peel, etc. The formula contains more than twenty ingredients, increasing production costs. Furthermore, long-term consumption of cassia seeds can cause certain side effects, as cassia seeds are considered a cold-natured food; those with weak spleen and stomach may experience a worsening of their condition upon consumption.

[0006] Therefore, in the field of health product technology, there is a strong demand for lipid-lowering and weight-loss compositions that can effectively reduce human body fat, are fast-acting, have good effects, and have no obvious side effects. Summary of the Invention

[0007] In view of the shortcomings of the existing technology, the purpose of this invention is to provide a lipid-lowering and weight-loss composition. This invention scientifically combines multiple components with different lipid-lowering and weight-loss mechanisms by rationally selecting and controlling their dosage, so that the resulting composition has the advantages of good effect, fast effect, and no dependence.

[0008] To achieve the above objectives, the present invention adopts the following technical solution:

[0009] A lipid-lowering and weight-loss composition comprising the following components in parts by weight: 10-15 parts chitosan, 20-35 parts tea bean extract, 5-10 parts papaya extract, 2-8 parts wolfberry extract, 2-10 parts immature bitter orange extract, 5-10 parts saponin extract, 2-6 parts compound postbiotics, and 5-10 parts dietary fiber.

[0010] The tea bean extract was prepared by the following method:

[0011] S1: Crush bitter tea, green tea leaves, green tea fruit, and white kidney beans, add anhydrous ethanol to the dry powder at a solid-liquid ratio of 1:25 and soak for 2 hours. Centrifuge to obtain the pre-soaked material soaked in anhydrous ethanol.

[0012] S2: Add an aqueous ethanol solution to the pre-impregnated material obtained in step S1 at a solid-liquid ratio of 1:25, then extract at 300W frequency for 3 hours, and centrifuge to obtain the supernatant.

[0013] S3: Add n-butanol to the supernatant obtained in step S2 at a volume ratio of 1:0.5 and extract to obtain the extract;

[0014] S4: The extract obtained in step S3 is dried under vacuum to obtain the tea bean extract.

[0015] Chitosan can bind with negatively charged lipids, fats, and bile acids in the body, preventing them from being absorbed and directly eliminating them from the body, thus playing a role in lowering lipids and losing weight.

[0016] Kuding tea contains a component called acetoside, which belongs to the phenylpropanoid glycoside class of compounds. It has a polyphenolic hydroxyl structure and can act on the β-sheet region formed by asparagine and serine of lipase through hydrogen bonding, causing protein structure-activity disruption, thereby inhibiting lipase biological activity, reducing the accumulation of blood cholesterol and triglycerides, and thus achieving the effect of lowering lipids and losing weight.

[0017] Tea fruit is another important part of the tea plant besides the tea leaf, including the fruit peel, seed husk, and kernel. With the approval of tea seed oil as a new resource food by the Ministry of Health in 2010, tea seed oil processing has flourished. However, this has also led to the large-scale production of tea fruit peel, a processing byproduct. This study utilizes α-amylase inhibitors extracted from green tea fruit and white kidney beans to reduce the production cost of the composite. In terms of efficacy, the α-amylase inhibitor binds to the active site of α-amylase, thereby blocking the binding of starch to α-amylase, inhibiting starch metabolism, hindering the digestion and breakdown of carbohydrates, slowing down glucose absorption, excreting excess carbohydrates, and preventing fat accumulation.

[0018] Green tea leaves contain catechins, which are believed to inhibit the absorption and digestion of fat. Studies have shown that green tea extract can reduce fat intake, thereby reducing weight and body fat percentage.

[0019] The enzymes in papaya can help digest fat and reduce its absorption. Meanwhile, the polysaccharides in goji berries are believed to reduce fat absorption and promote fat breakdown.

[0020] Synephedrine is the main active ingredient in Fructus Aurantii Immaturus extract. It can promote fat breakdown, lower blood lipids, oxidize fat, control appetite, and help with weight loss. It can accelerate fat metabolism. Users can expect variable effects including burning excess calories, reducing appetite, and increasing satiety, all of which may lead to weight loss.

[0021] The main active ingredient in saponin extract is flavanol, which can inhibit lipase, which breaks down fat for absorption, thus preventing fat from being absorbed by the body and having a fat-burning effect.

[0022] Postbiotics are preparations of non-living microorganisms and / or their components that are beneficial to the host's health. Compared to probiotics, they have advantages such as direct and rapid function (no need for bacterial growth and colonization), no population restrictions (suitable for various populations), and good preservation (longer and more stable shelf life). Inactivated probiotic cells can adhere to the intestinal epithelial cells of humans and animals, forming a biofilm, competitively excluding pathogenic microorganisms, thereby protecting the intestines; cells and their metabolites can directly kill pathogenic microorganisms; probiotic preparations can stimulate the growth of intestinal acid-producing microorganisms such as lactic acid bacteria, thereby adjusting the intestinal microecological balance.

[0023] Dietary fiber can absorb a large amount of water and swell rapidly in the stomach and intestines. Since dietary fiber has no nutrients and cannot be digested by the stomach and intestines, it will continuously produce a feeling of fullness, reducing the body's desire and need for food intake; at the same time, it will affect the absorption of available carbohydrates in the intestines, so that people do not feel hungry.

[0024] This invention uses chitosan and tea bean extract as the main lipid-lowering and weight-loss ingredients. Chitosan reduces the digestion and absorption of fat, while tea bean extract reduces the digestion and absorption of carbohydrates, thus reducing the body's energy absorption through a two-pronged approach. Papaya extract and wolfberry extract synergistically inhibit fat absorption. Citrus aurantium extract and saponin extract accelerate fat breakdown. A complex of prebiotics promotes the growth of beneficial bacteria and inhibits the proliferation of harmful bacteria, maintaining the balance of intestinal flora and reducing fat accumulation in the intestines; simultaneously, it regulates the appetite center by influencing the secretion of neurotransmitters and hormones, reducing food intake and appetite. Dietary fiber enhances satiety and reduces appetite.

[0025] Preferably, the weight ratio of bitter tea, green tea leaves, green tea fruit, and white kidney beans in step S1 is (1-5):(2-5):(5-10):(10-15).

[0026] Preferably, the volume concentration of the ethanol aqueous solution in step S2 is 20-30%, and the pH is 3.5-4.5.

[0027] Preferably, the centrifugation speed in both steps S1 and S2 is 15000 rpm and the time is 30 min.

[0028] Preferably, the composite postbiotic includes at least two of Bifidobacterium lactis postbiotic, Bifidobacterium breve postbiotic, and Lactobacillus plantarum postbiotic.

[0029] Preferably, the dietary fiber includes at least one of pectin, corn flour, mulberry powder, bitter melon powder, and kudzu root powder.

[0030] Preferred application of a lipid-lowering and weight-loss composition: weigh each component according to the weight ratio, mix them, add an appropriate amount of pharmaceutically acceptable excipients, grind them into powder, sieve, sterilize with ultraviolet light, and obtain an intermediate for an oral preparation.

[0031] Preferably, the oral preparation is any one of tablets, dispersants, soft capsules, granules, pills, drop pills, and gels.

[0032] To further broaden the application scope of the compositions of the present invention, the intermediates obtained above can be prepared into various dosage forms by adding common excipients. For example, the intermediates can be prepared into tablets with starch, powdered sugar, microcrystalline cellulose, inorganic salts, binders and mannitol; the intermediates can be prepared into capsules with polyethylene glycols, plasticizers, disintegrants, curcumin, iron oxide, wetting agents and suspending agents.

[0033] Preferably, an application of a lipid-lowering and weight-loss composition is as follows: each component is weighed according to the weight ratio and mixed in a mixing pot, and cetearyl alcohol, grape seed oil and peony seed oil are added. The mixture is kept at a constant temperature of 50°C and stirred evenly. The temperature is then lowered to 40°C, and tea anthocyanins, capsaicin, thickener (sodium chloride) and preservative (methylparaben) are added. After homogenization, the mixture is cooled to room temperature to obtain a topical lipid-lowering and weight-loss product.

[0034] To further broaden the application scope of the composition of the present invention, the lipid-lowering and weight-loss composition prepared above can be combined with conventional external excipients to make common external lipid-lowering and weight-loss products, such as hot compress creams, topical oils, massage lotions, etc.

[0035] Compared with the prior art, the present invention has the following beneficial effects:

[0036] (1) This invention starts from the mechanism of reducing fat absorption, reducing carbohydrate absorption, accelerating fat decomposition, reducing fat accumulation, enhancing satiety and reducing appetite. It selects a variety of food and medicine homologous raw materials and improves the lipid-lowering and weight-loss effects of the composition through scientific compatibility, without producing toxic side effects and dependence.

[0037] (2) By controlling the weight ratio of bitter tea, green tea leaves, green tea fruit and white kidney bean to (1-5):(2-5):(13-20):(2-5), the present invention can improve the lipid-lowering synergistic effect among drug components.

[0038] (3) The present invention extracts α-amylase inhibitors from green tea fruit and white kidney beans, makes reasonable use of waste tea fruit peel, reduces the amount of white kidney beans used, and reduces the production cost of the composition.

[0039] (4) The α-amylase inhibitor was extracted by ultrasonic extraction, which reduced the extraction temperature and maintained the activity of the α-amylase inhibitor.

[0040] (5) The composition of the present invention is a powder that can be taken directly with drinking water, which is safe and hygienic; it is also easy to make into other dosage forms, which makes it convenient for consumers to store, carry and take. Detailed Implementation

[0041] It is worth noting that the raw materials used in this invention are all commercially available products, and therefore their sources are not specifically limited.

[0042] The lipid-lowering and weight-loss composition of the present invention comprises the following components in parts by weight: 10-15 parts chitosan, 20-35 parts tea bean extract, 5-10 parts papaya extract, 2-8 parts wolfberry extract, 2-10 parts immature bitter orange extract, 5-10 parts saponin extract, 2-6 parts compound postbiotics, and 5-10 parts dietary fiber.

[0043] The above-mentioned tea bean extract was prepared by the following method:

[0044] S1: Grind 5g of bitter tea, 5g of green tea leaves, 18g of green tea peel, and 5g of white kidney beans into powder. Add the resulting dry powder to 1950ml of anhydrous ethanol and soak for 2 hours. Centrifuge at 15000rpm for 30 minutes to obtain the pre-soaked material after soaking in anhydrous ethanol.

[0045] S2: Add the pre-impregnated material obtained in step S1 to 1950 ml of ethanol aqueous solution, then extract at 300 W for 3 hours, centrifuge at 15000 rpm for 30 minutes to obtain 1950 ml of supernatant; wherein, the volume concentration of ethanol aqueous solution is 20-30%, and the pH is 3.5-4.5;

[0046] S3: Add 975 ml of n-butanol to the supernatant obtained in step S2 and extract to obtain the extract;

[0047] S4: The extract obtained in step S3 is dried under vacuum to obtain the tea bean extract.

[0048] The aforementioned composite postbiotic is composed of Bifidobacterium lactis postbiotic, Bifidobacterium breve postbiotic, and Lactobacillus plantarum postbiotic in a mass ratio of 1:1:2.

[0049] The dietary fiber mentioned above is composed of pectin, corn flour, mulberry powder, bitter melon powder, and kudzu root powder in a mass ratio of 5:2:1:1:1.

[0050] Example 1

[0051] A lipid-lowering and weight-loss composition is prepared as follows: 10g of chitosan, 20g of tea bean extract, 5g of papaya extract, 2g of wolfberry extract, 2g of immature bitter orange extract, 2g of saponin extract, 2g of compound postbiotic, and 5g of dietary fiber are weighed, mixed, and an appropriate amount of binder is added. The mixture is then ground into powder, passed through a 50-mesh pharmaceutical sieve, and sterilized under an ultraviolet sterilizing lamp for 5 hours to obtain a powdered oral preparation intermediate.

[0052] Example 2

[0053] A lipid-lowering and weight-loss composition is prepared as follows: 13g of chitosan, 30g of tea bean extract, 8g of papaya extract, 5g of wolfberry extract, 6g of immature bitter orange extract, 8g of saponin extract, 4g of compound postbiotic, and 8g of dietary fiber are weighed, mixed, and an appropriate amount of binder is added. The mixture is then ground into powder, passed through a 50-mesh pharmaceutical sieve, and sterilized under an ultraviolet sterilizing lamp for 5 hours to obtain a powdered oral preparation intermediate.

[0054] Example 3

[0055] A lipid-lowering and weight-loss composition is prepared as follows: 15g of chitosan, 35g of tea bean extract, 10g of papaya extract, 8g of wolfberry extract, 10g of immature bitter orange extract, 10g of saponin extract, 6g of compound postbiotic, and 10g of dietary fiber are weighed, mixed, and an appropriate amount of binder is added. The mixture is then ground into powder, passed through a 50-mesh pharmaceutical sieve, and sterilized under an ultraviolet sterilizing lamp for 5 hours to obtain a powdered oral preparation intermediate.

[0056] Comparative Example 1

[0057] Compared with Example 3, the difference is that chitosan was not added.

[0058] Comparative Example 2

[0059] Compared with Example 3, the difference is that no tea bean extract was added.

[0060] Comparative Example 3

[0061] Compared with Example 3, the difference is that papaya extract and wolfberry extract were not added.

[0062] Comparative Example 4

[0063] Compared with Example 3, the difference is that no Citrus aurantium extract and Saponin extract were added.

[0064] Comparative Example 5

[0065] Compared with Example 3, the difference is that no composite post-genetic agent was added.

[0066] Comparative Example 6

[0067] Compared with Example 3, the difference is that no dietary fiber was added.

[0068] Comparative Example 7

[0069] Compared with Example 3, the difference is that the tea bean extract was obtained from 5g of bitter tea, 5g of green tea leaves, 5g of green tea peel, and 18g of white kidney beans.

[0070] Comparative Example 8

[0071] Compared with Example 3, the difference is that the tea bean extract was obtained from 10g of bitter tea, 10g of green tea leaves, 8g of green tea peel, and 5g of white kidney beans.

[0072] Effect test

[0073] (1) Weight Test: 120 healthy male SD rats weighing 200-220g were selected. After 30 days of swimming training, they were fed a high-calorie diet for four weeks to obtain obese SD rats. The initial weights were recorded, and the maximum and minimum weights were removed to calculate the initial average weight of each group. Ten obese SD rats were divided into 12 groups. One group served as a control group, fed only a normal diet. The other seven groups were fed the normal diet plus the test sample (i.e., the combinations of Examples 1-3 and Comparative Examples 1-8). The test sample was administered for one month at a dose of 0.5g three times daily. The final weights were recorded, and the maximum and minimum weights were removed to calculate the final average weight of each group. After the experiment, the rats were weighed, and the results are shown in Table 1.

[0074] Table 1. Changes in body weight of SD rats

[0075]

[0076]

[0077] As shown in Table 1, after one month of use, SD rats showed good weight loss effects with the compositions of Examples 1 to 3 of this invention, with Example 3 being the best. The higher the content of the weight loss active ingredients, the better the effect.

[0078] Comparing Example 3 with Comparative Examples 1-6, the weight loss effect of the composition was significantly worse when chitosan, tea bean extract, complex postbiotics, or dietary fiber were not added to the formulation, or when papaya extract and wolfberry extract were not added at the same time, or when immature bitter orange extract and saponin extract were not added at the same time.

[0079] Comparing Example 3 and Comparative Example 7, under the premise of equal total mass content, increasing green tea peel and decreasing white kidney bean resulted in similar weight loss effects, indicating that green tea peel can be fully utilized to replace white kidney bean in the extraction of α-amylase inhibitors.

[0080] Comparing Example 3 with Comparative Examples 7-8, under the premise of equal total mass content, adjusting the weight ratio of bitter tea, green tea leaves, green tea fruit, and white kidney beans to (1-5):(2-5):(13-20):(2-5) can improve the lipid-lowering synergistic effect among drug components.

[0081] (2) Exhaustion test: In order to test the health status of the SD rats after weight loss, the SD rats were subjected to an endurance test. The time required for the SD rats to reach the state of exhaustion was tested. When the rat's head was submerged in the water for 6 seconds without surfacing, it was judged to be in the state of exhaustion. The exhaustion time was recorded. The longest exhaustion time and the shortest exhaustion time were removed to obtain the average exhaustion time. The results are shown in Table 2.

[0082] Table 2 Swimming Exhaustion Test of SD Rats

[0083] Group Mean time to exhaustion (min) Example 1 45.5 Example 2 46.7 Example 3 48.4 Comparative Example 1 40.5 Comparative Example 2 42.6 Comparative Example 3 43.5 Comparative Example 4 45.4 Comparative Example 5 46.2 Comparative Example 6 44.7 Comparative Example 7 46.1 Comparative Example 8 45.5 Blank group 44.2

[0084] As shown in Table 2, rats fed with the compositions of Examples 1-3 had good endurance, while the endurance of rats fed with Comparative Examples 1-8 was not significantly different, indicating that consuming the compositions of the present invention for weight loss did not affect the health of the rats.

[0085] The above description is merely a preferred embodiment of the present invention. The scope of protection of the present invention is not limited to the above embodiments. All technical solutions falling within the scope of the present invention's concept are within the scope of protection of the present invention. It should be noted that for those skilled in the art, any improvements and modifications made without departing from the principles of the present invention should also be considered within the scope of protection of the present invention.

Claims

1. A lipid-lowering and weight-loss composition, characterized in that, It includes the following components by weight: 10-15 parts chitosan, 20-35 parts tea bean extract, 5-10 parts papaya extract, 2-8 parts wolfberry extract, 2-10 parts immature bitter orange extract, 5-10 parts saponin extract, 2-6 parts complex postbiotics, and 5-10 parts dietary fiber. The tea bean extract was prepared by the following method: S1: Crush bitter tea, green tea leaves, green tea fruit, and white kidney beans, add anhydrous ethanol to the dry powder at a solid-liquid ratio of 1:25 and soak for 2 hours. Centrifuge to obtain the pre-soaked material soaked in anhydrous ethanol. S2: Add an aqueous ethanol solution to the pre-impregnated material obtained in step S1 at a solid-liquid ratio of 1:25, then extract at a frequency of 300W for 3 hours, and centrifuge to obtain the supernatant. S3: Add n-butanol to the supernatant obtained in step S2 at a volume ratio of 1:0.5 and extract to obtain the extract; S4: The extract obtained in step S3 is dried under vacuum to obtain the tea bean extract.

2. The lipid-lowering and weight-loss composition according to claim 1, characterized in that, In step S1, the weight ratio of bitter tea, green tea leaves, green tea fruit, and white kidney beans is (1-5):(2-5):(13-20):(2-5).

3. The lipid-lowering and weight-loss composition according to claim 1, characterized in that, The volume concentration of the ethanol aqueous solution in step S2 is 20-30%, and the pH is 3.5-4.

5.

4. The lipid-lowering and weight-loss composition according to claim 1, characterized in that, In both steps S1 and S2, the centrifugation speed is 15000 rpm and the time is 30 min.

5. The lipid-lowering and weight-loss composition according to claim 1, characterized in that, The composite postbiotic includes at least two of the following: Bifidobacterium lactis postbiotic, Bifidobacterium breve postbiotic, and Lactobacillus plantarum postbiotic.

6. The lipid-lowering and weight-loss composition according to claim 1, characterized in that, The dietary fiber includes at least one of pectin, corn flour, mulberry powder, bitter melon powder, and kudzu root powder.

7. The application of a lipid-lowering and weight-loss composition as described in any one of claims 1 to 6, characterized in that, Weigh each component according to the weight ratio, mix them, add an appropriate amount of pharmaceutically acceptable excipients, grind them into powder, sieve, sterilize with ultraviolet light, and obtain an intermediate for oral preparation.

8. The application of the lipid-lowering and weight-loss composition according to claim 7, characterized in that, The oral preparation is any one of tablets, dispersants, soft capsules, granules, pills, drop pills, or gels.

9. The application of a lipid-lowering and weight-loss composition as described in any one of claims 1 to 6, characterized in that, Weigh each component according to the weight ratio and mix them in a mixing pot. Add cetearyl alcohol, grape seed oil, and peony seed oil. Maintain a constant temperature of 50°C and stir evenly. Cool down to 40°C and add tea greens, capsaicin, thickener, and preservative. After homogenization, cool to room temperature to obtain a topical lipid-lowering and weight-loss product.

10. The application of the lipid-lowering and weight-loss composition according to claim 9, characterized in that, The topical lipid-lowering and weight-loss product is any one of hot compress cream, topical oil, or massage lotion.

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