Protein binding toxoid adsorbent, preparation method and application

By preparing porous resin adsorbents with quaternary ammonium salt structures, the problem of difficult removal of PBUTs in hemodialysis was solved, achieving highly selective and high-capacity toxin adsorption, improving blood compatibility and safety, and reducing preparation and environmental risks.

CN121892099APending Publication Date: 2026-04-21CHONGQING TIANWAITIAN BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING TIANWAITIAN BIOTECHNOLOGY CO LTD
Filing Date
2026-01-30
Publication Date
2026-04-21

AI Technical Summary

Technical Problem

Existing hemodialysis techniques are ineffective at removing protein-bound toxoids (PBUTs), and traditional adsorbents suffer from poor selectivity, poor biocompatibility, and safety issues during preparation.

Method used

Protein-bound toxoid adsorbents are prepared by using porous resins with quaternary ammonium salt structures through suspension polymerization and quaternization reaction. A rigid-flexible cross-linked network is constructed using DVB and MAGME, and by combining the hydrophilic groups of MAGME with the quaternary ammonium salt grafting sites, high selectivity and high adsorption capacity are achieved.

Benefits of technology

It achieves high capacity and high selectivity adsorption of PBUTs, reduces hemolysis rate, improves blood compatibility, and the preparation process is safe and environmentally friendly, reducing the risk of environmental pollution and demonstrating significant cost-effectiveness.

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Abstract

The invention belongs to the technical field of blood purification, and discloses a protein binding toxoid adsorbent, a preparation method and application. The adsorbent is porous resin with a quaternary ammonium salt structure, and the porous resin is obtained by carrying out suspension polymerization reaction on a styrene monomer and a co-crosslinking agent; the co-crosslinking agent comprises divinyl benzene and methacrylamide ethylene glycol methyl ether. The adsorbent has excellent adsorption performance and blood compatibility, and effectively solves the problem of accumulation of protein binding toxoid in the body of a chronic kidney disease patient. During preparation, firstly, raw materials such as styrene monomers, divinyl benzene, methacrylamide ethylene glycol methyl ether and the like are subjected to suspension polymerization to prepare microspheres, and then tetramethyl diamine is grafted to the surfaces of the microspheres through quaternization reaction. The preparation method is simple in process, mild in reaction condition and high in safety. The adsorbent disclosed by the invention can be applied to the fields of preparation of blood perfusion devices and clinical removal of protein binding toxoid, and has a wide clinical application prospect.
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Citation Information

Patent Citations

  • Adsorbent, preparation method thereof, and resin containing long-chain quaternary ammonium salt

    CN105126785A