Preparation method of traditional Chinese medicine composition spice with lasting fragrance emitting function

Abstract

The invention provides a preparation method of a traditional Chinese medicine composition spice with a lasting fragrance emitting function. The preparation method comprises the following steps: (1) raw material pretreatment, (2) superfine grinding, (3) surface modification, (4) slow release agent preparation, (5) compounding and mixing, and (6) irradiation sterilization. Nanoscale pits are constructed through plasma surface modification to enhance the specific surface area, efficient controlled release and activity preservation of volatile components are achieved in combination with the synergistic effect of gradient heating inclusion and partitioned irradiation sterilization, and the fragrance emission duration is remarkably prolonged on the premise that the initial fragrance intensity is kept.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine fragrance technology, specifically relating to a method for preparing a traditional Chinese medicine composition fragrance with long-lasting fragrance function. Background Technology

[0002] Traditional Chinese medicine fragrance compounds are air purification products made from natural medicinal materials such as mugwort, atractylodes, and calamus. They are widely used in indoor environments, vehicle interiors, and personal sachets. Their core function is to achieve antibacterial, insect-repellent, and aromatic effects through the continuous release of volatile components. However, in practical applications, these products have significant drawbacks: due to the lack of an effective control mechanism for volatile components, the fragrance duration at room temperature (25°C) is generally less than 24 hours, requiring users to frequently replace the sachets. For example, the method disclosed in patent CN109876541A, which simply involves crushing and filling mugwort and cinnamon, only results in a fragrance duration of about 18 hours.

[0003] To address this issue, existing technologies employ microencapsulation techniques. A typical example is the gelatin-gum arabic encapsulation of menthol technology proposed in patent CN112274645B. While this extends the fragrance release time to 48 hours, it introduces new drawbacks: the encapsulating material hinders aroma release, causing a more than 40% decrease in aroma intensity within the initial 24 hours, resulting in widespread consumer complaints about a weak fragrance. Existing technologies also suffer from systemic defects caused by insufficient raw material processing: First, traditional hot air drying is often carried out continuously at 45℃, leading to a loss rate of over 25% for heat-sensitive active ingredients such as cinnamaldehyde, directly impacting core efficacy. Second, conventional pulverization processes only require passing through an 80-mesh sieve without controlling the pulverization temperature, resulting in uneven powder particle size distribution. After filling the sachets, the clumping rate reaches as high as 30%, reducing the effective release surface area by 50%. Third, the sterilization process uses ultraviolet surface irradiation, which achieves less than 90% bacterial kill rate within the medicinal powder, posing a hygiene and safety hazard.

[0004] It is worth noting that the aforementioned defects are interconnected, forming a closed-loop technical challenge: increasing the inclusion rate sacrifices aroma intensity, lowering the drying temperature prolongs the processing time, and reducing the particle size exacerbates heat-sensitive losses. Current technologies have not yet achieved sustained fragrance dispersion while maintaining aroma intensity, nor have they systematically solved problems such as component loss, clumping, and incomplete sterilization. Therefore, it is necessary to design a method for preparing a functional, sustained-release fragrance from traditional Chinese medicine compositions. Summary of the Invention

[0005] To overcome the shortcomings of the existing technology, a method for preparing a traditional Chinese medicine composition fragrance with long-lasting fragrance is provided.

[0006] To achieve the above objectives, the present invention provides the following technical solution: A method for preparing a long-lasting, aromatic traditional Chinese medicine composition fragrance, comprising the following steps: (1) Raw material pretreatment: Take 120-180 parts by weight of Artemisia argyi, 90-120 parts by weight of cinnamon, 85-120 parts by weight of Atractylodes lancea, and 110-150 parts by weight of Acorus tatarinowii, dry them, and obtain primary dried material; (2) Ultrafine grinding: The primary dried material is ground to obtain the basic powder; (3) Surface modification: The base powder is subjected to plasma surface modification treatment to obtain activated powder with a specific surface area greater than 8.0 m² / g; (4) Preparation of sustained-release agent: Weigh 110-150 parts by weight of menthol and 220-300 parts by weight of β-cyclodextrin, add deionized water to form a suspension, stir in a water bath, filter and dry to obtain the inclusion complex, and the obtained inclusion complex is the sustained-release agent; (5) Compound mixing: Add 120-160 parts by weight of patchouli, 50-65 parts by weight of clove, 100-140 parts by weight of angelica dahurica and 110-150 parts by weight of cardamom powder to the activated powder, then add the inclusion complex and mix to form a mixture; (6) Irradiation sterilization: The mixture is transported to an electron accelerator irradiation field for irradiation to obtain the final product of a traditional Chinese medicine composition fragrance with long-lasting fragrance.

[0007] Furthermore, a method for preparing a traditional Chinese medicine composition fragrance with long-lasting aroma includes the following steps: (1) Raw material pretreatment: Take 120-180 parts by weight of Artemisia argyi, 90-120 parts by weight of cinnamon, 85-120 parts by weight of Atractylodes lancea and 110-150 parts by weight of Acorus tatarinowii, and dry them at 40-50℃ until the moisture content is less than 8% to obtain primary dried material; (2) Ultrafine grinding: The primary dried material obtained in step (1) is ground to 70-100 mesh at a temperature of 20-25℃ to obtain basic powder; (3) Surface modification: The base powder obtained in step (2) is subjected to plasma surface modification treatment to obtain activated powder, the specific surface area of ​​which is greater than 8.0 m² / g; (4) Preparation of sustained-release agent: Weigh 110-150 parts by weight of menthol and 220-300 parts by weight of β-cyclodextrin, add deionized water to form a suspension, stir in a water bath at 40-45℃ for 120 minutes, filter and dry to obtain the inclusion complex, and the obtained inclusion complex is the sustained-release agent. (5) Compound mixing: Add 120-160 parts by weight of patchouli, 50-65 parts by weight of clove, 100-140 parts by weight of angelica dahurica and 110-150 parts by weight of cardamom powder of 80 mesh to the activated powder obtained in step (3), and then add the inclusion complex obtained in step (4) to form a mixture. (6) Irradiation sterilization: The mixture obtained in step (5) is transported to the electron accelerator irradiation field and irradiated with a dose of 8000-15000 Gy at an energy of 10 MeV to obtain the final product of the Chinese herbal medicine composition fragrance with long-lasting fragrance function.

[0008] In step (2), an air jet mill is used for pulverization, and the air pressure of the air jet mill is 0.65 MPa.

[0009] The specific steps of step (3) are as follows: place the base powder in a plasma device, introduce argon gas to replace the air, and perform plasma surface modification treatment at a power of 100-150 watts for 10-20 minutes to obtain activated powder with nanoscale pits formed on the surface. The pits are 100-200 nanometers deep and 0.5-1.5 micrometers in diameter.

[0010] The plasma surface modification treatment uses a 5000 Hz pulse mode, with a single pulse duration of 0.1 milliseconds and a duty cycle of 60%.

[0011] In step (5), the patchouli, cloves, angelica, and cardamom need to be dried at 60-65 ℃ for 6-8 hours before being pulverized and passed through an 80-mesh sieve.

[0012] In step (5), 5-15 parts by weight of a slow-release carrier are added during compounding. The slow-release carrier is polylactic acid microspheres or diatomaceous earth.

[0013] The polylactic acid microspheres have a particle size of 50-80 micrometers. Before being added, the polylactic acid microspheres need to be pre-etched in a 0.1-0.2 mol / L NaOH solution for 30-60 minutes.

[0014] During the water bath stirring process in step (4), a gradient heating program is adopted: maintain 40°C for the first 30 minutes, then raise it to 45°C at a rate of 0.5°C per minute and maintain it for 90 minutes.

[0015] Step (5) Speed ​​adjustment in stages during mixing: run at 100 rpm for the first 10 minutes, increase to 200 rpm for the middle 10 minutes, and decrease back to 150 rpm for the last 10 minutes.

[0016] Step (6) During irradiation, zoned dose control is implemented: the upper layer of the material receives 10,000 Gy, the middle layer receives 12,000 Gy, and the lower layer receives 8,000 Gy.

[0017] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows: 1. This application effectively prolongs the fragrance duration of a traditional Chinese medicine composition by utilizing the synergistic effect of plasma surface modification and sustained-release agent construction. The nanoscale pit structure formed on the surface of the base powder by plasma treatment significantly increases the specific surface area, while simultaneously forming a two-level controlled-release mechanism through molecular inclusion of β-cyclodextrin in the sustained-release agent. This structure promotes the uniform adhesion of volatile components to the sachet carrier and slows down the diffusion rate of aroma molecules through the hydrophobic cavities of cyclodextrin, achieving sustained release while maintaining the initial aroma intensity.

[0018] 2. The gradient heating inclusion process employed in this invention significantly reduces the loss of heat-sensitive components. During the preparation of the sustained-release agent, a staged temperature control strategy allows menthol and the inclusion material to gradually complete molecular self-assembly. This control method avoids the loss of volatiles caused by localized overheating, and is particularly beneficial for preserving heat-sensitive active ingredients such as cinnamaldehyde contained in cinnamon. Combined with staged speed-adjustment during the compounding stage, the uniformity of powder distribution at different densities is ensured, preventing clumping of the sachets.

[0019] 3. This invention employs graded irradiation sterilization, utilizing ultra-high-energy rays generated by an electron accelerator irradiation field, combined with a zoned dose control design from the upper to the lower layers, to achieve penetrating treatment of the three-dimensional structure of the mixture. The upper, middle, and lower layers receive different doses of irradiation, effectively balancing the efficiency of microbial killing with the need to protect active ingredients. This method overcomes the shortcomings of traditional ultraviolet sterilization in incompletely killing microorganisms within the powder, while also avoiding aroma degradation caused by high-temperature sterilization.

[0020] 4. The design of the solubilizing and slow-release carrier in the compounding process of this invention further optimizes the release curve. The added polylactic acid microspheres, after being etched with alkaline solution, form a porous structure, which together with diatomaceous earth constructs a physical barrier layer. This type of carrier, while retaining volatile components, regulates the diffusion rate of aroma molecules through capillary action, forming a complementary effect with the chemical inclusion mechanism. Especially when surface-etched polylactic acid microspheres are used, their microporous structure can adsorb some essential oil components, triggering a secondary release when environmental humidity changes. Detailed Implementation

[0021] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0022] The sources of various raw materials in this application are briefly described as follows: Artemisia argyi was purchased from Anhui Bozhou Yonggang Pharmaceutical Co., Ltd., and the batch number must meet the standards of the 2020 edition of the Chinese Pharmacopoeia, requiring no sulfur fumigation and an impurity content of ≤2%. Cinnamon was selected from Guangxi Nanning Guize Pharmaceutical Co., Ltd., with trees over ten years old and a cinnamaldehyde content ≥85%, product number GZ-2023-CIN. Atractylodes lancea was selected from Chengde Tianyuan Pharmaceutical Co., Ltd., characterized by obvious cinnamon spots and a yellowish-white cross-section, product number BCZ-01. Acorus tatarinowii was purchased from the Tengchong Traditional Chinese Medicine Market in Yunnan, with a diameter of 1 to 1.5 cm and a fibrous root residue of ≤5%. Patchouli was sourced from Guangzhou Caizhilin Pharmaceutical Co., Ltd., with a volatile oil content ≥0.3%, batch number GPHX-2305. Cloves were selected from imported Indonesian cloves, with bud fullness ≥90%, produced by PT. Indo Aroma, product number ID-CLOVE. Angelica dahurica strips from Sichuan Suining Xinyuan Traditional Chinese Medicine Pieces Co., Ltd. were used, with a diameter ≥2 cm and sulfur residue ≤10 mg / kg. Amomum tsao-ko was selected from Yunnan Wenshan Yunlingshan Amomum tsao-ko Planting Professional Cooperative; the kernels were grayish-brown to brownish-red, with a moisture content ≤12%. Menthol was premium grade from Jiangxi Ji'an Natural Fragrance Factory, CAS number 89-78-1. β-Cyclodextrin was purchased from Sigma-Aldrich Shanghai Trading Co., Ltd., CAS number 7585-39-9, model C4767-1KG, and must meet USP standards. Polylactic acid microspheres were selected from NatureWorks, USA, type 4032D. Diatomaceous earth was selected from EP Minerals, type Dicalite 43. Sodium hydroxide was purchased from Sinopharm Chemical Reagent Co., Ltd., analytical grade, CAS number 1310-73-2.

[0023] The technical solution of this application is as follows: A method for preparing a long-lasting, aromatic traditional Chinese medicine composition fragrance, comprising the following steps: (1) Raw material pretreatment: Take 120-180 parts by weight of Artemisia argyi, 90-120 parts by weight of cinnamon, 85-120 parts by weight of Atractylodes lancea and 110-150 parts by weight of Acorus tatarinowii, and dry them at 40-50℃ until the moisture content is less than 8% to obtain primary dried material; (2) Ultrafine grinding: The primary dried material obtained in step (1) is ground to 70-100 mesh at a temperature of 20-25℃ to obtain basic powder; (3) Surface modification: The base powder obtained in step (2) is subjected to plasma surface modification treatment to obtain activated powder, the specific surface area of ​​which is greater than 8.0 m² / g; (4) Preparation of sustained-release agent: Weigh 110-150 parts by weight of menthol and 220-300 parts by weight of β-cyclodextrin, add deionized water to form a suspension, stir in a water bath at 40-45℃ for 120 minutes, filter and dry to obtain the inclusion complex, and the obtained inclusion complex is the sustained-release agent. (5) Compound mixing: Add 120-160 parts by weight of patchouli, 50-65 parts by weight of clove, 100-140 parts by weight of angelica dahurica and 110-150 parts by weight of cardamom powder of 80 mesh to the activated powder obtained in step (3), and then add the inclusion complex obtained in step (4) to form a mixture. (6) Irradiation sterilization: The mixture obtained in step (5) is transported to the electron accelerator irradiation field and irradiated with a dose of 8000-15000 Gy at an energy of 10 MeV to obtain the final product of the Chinese herbal medicine composition fragrance with long-lasting fragrance function.

[0024] The feature is that, in step (2), an air jet mill is used for pulverization, and the air pressure of the air jet mill is 0.65 MPa.

[0025] The specific steps of step (3) are as follows: the base powder is placed in a plasma device, argon gas is introduced to replace the air, and plasma surface modification treatment is performed at a power of 100-150 watts for 10-20 minutes to obtain activated powder with nanoscale pits formed on the surface. The pits are 100-200 nanometers deep and 0.5-1.5 micrometers in diameter.

[0026] The plasma surface modification treatment is characterized by using a 5000 Hz pulse mode, with a single pulse duration of 0.1 milliseconds and a duty cycle of 60%.

[0027] The characteristic feature is that the patchouli, clove, angelica, and cardamom in step (5) need to be dried at 60-65 ℃ for 6-8 hours in advance, and then pulverized and passed through an 80-mesh sieve.

[0028] The feature is that, in step (5), 5-15 parts by weight of a slow-release carrier are added during compounding, wherein the slow-release carrier is polylactic acid microspheres or diatomaceous earth.

[0029] The polylactic acid microspheres have a particle size of 50-80 micrometers. Before being added, the polylactic acid microspheres need to be pre-etched in a 0.1-0.2 mol / L NaOH solution for 30-60 minutes.

[0030] During the water bath stirring process in step (4), a gradient heating program is adopted: maintain 40°C for the first 30 minutes, then raise it to 45°C at a rate of 0.5°C per minute and maintain it for 90 minutes.

[0031] Step (5) Speed ​​adjustment in stages during mixing: run at 100 rpm for the first 10 minutes, increase to 200 rpm for the middle 10 minutes, and decrease back to 150 rpm for the last 10 minutes.

[0032] Step (6) During irradiation, zoned dose control is implemented: the upper layer of the material receives 10,000 Gy, the middle layer receives 12,000 Gy, and the lower layer receives 8,000 Gy.

[0033] This application utilizes a matching design of process parameters. The ultrafine grinding stage is controlled at a low temperature to prevent damage to volatile substances from the heat effect of grinding. The surface modification process employs pulsed energy impact treatment at a specific frequency to precisely control the morphology of the pits while preventing powder carbonization. These refined control methods, along with the addition of a slow-release carrier and gradient mixing operations, form a complete technical closed loop, ultimately constructing a traditional Chinese medicine fragrance system that combines durability and stable aroma intensity.

[0034] The nano-pits formed by surface modification significantly increase the specific surface area of ​​the powder, resulting in a doubling of the amount of fragrance adhering to the carrier. Combined with the molecular inclusion effect of β-cyclodextrin in the sustained-release agent, a dual controlled-release mechanism of physical adsorption and chemical bonding is constructed. This synergistic effect avoids the aroma intensity decay caused by traditional microencapsulation and achieves a long-lasting fragrance diffusion of over 120 hours by slowing down the diffusion rate.

[0035] The gradient temperature encapsulation process reduces heat-sensitive loss, low-temperature pulverization at 20-25℃ inhibits cinnamaldehyde volatilization, and zoned irradiation sterilization precisely balances microbial killing and component protection. These three elements form a complete protective chain for temperature-sensitive components, raising the retention rate of heat-sensitive active substances to a new industry high.

[0036] This method systematically addresses industry pain points such as the trade-off between aroma intensity and duration, and the mutual constraints between component loss and sterilization requirements through cross-scale innovations in material interface modification, release kinetics regulation, and precise energy delivery.

[0037] The technical solutions of the present invention are further illustrated below through examples and comparative examples, but the scope of protection of the present invention is not limited thereto. Example 1

[0038] Take 180 parts by weight of Artemisia argyi, 105 parts by weight of cinnamon, 85 parts by weight of Atractylodes lancea, and 150 parts by weight of Acorus tatarinowii, and dry them in an oven at 50 degrees Celsius until the moisture content is 7.9%. Put the primary dried material into an Alpine 200AFG airflow mill and pulverize it to 70 mesh at 25 degrees Celsius, controlling the air pressure at 0.65 MPa. Place the base powder in an Ebara PDE-300 plasma device, introduce argon gas, and treat it at 150 watts for 10 minutes with a pulse frequency of 5000 Hz and a duty cycle of 60%, obtaining an activated powder with a specific surface area of ​​8.9 m² / g. Separately, take 110 parts by weight of menthol and 300 parts by weight of β-cyclodextrin, add deionized water to form a suspension, and use a gradient temperature program: maintain at 40 degrees Celsius for 30 minutes, then increase to 45 degrees Celsius at a rate of 0.5 degrees Celsius per minute, continue for 90 minutes, filter and dry to obtain a sustained-release agent. Add 160 parts by weight of patchouli, 65 parts by weight of clove, 140 parts by weight of angelica dahurica, and 150 parts by weight of cardamom (pre-dried at 65°C for 6 hours and then pulverized) of 80-mesh powder to the activated powder. Then add a slow-release agent and 15 parts by weight of diatomaceous earth. Mix the mixture in a three-dimensional mixer with staged speed adjustments: 100 rpm for 10 minutes, 200 rpm for 10 minutes, and 150 rpm for 10 minutes. The mixture is then transported to an electron accelerator irradiation field, where it receives irradiation doses of 10,000 Gy in the upper layer, 12,000 Gy in the middle layer, and 8,000 Gy in the lower layer to obtain the final product. Example 2

[0039] In this embodiment, the similarities to those in Embodiment 1 will not be repeated, and the differences are as follows: 120 parts by weight of Artemisia argyi, 120 parts by weight of cinnamon, 120 parts by weight of Atractylodes lancea, and 110 parts by weight of Acorus tatarinowii were dried at 40°C to a moisture content of 7.5%. Pulverization was carried out at 20°C to a particle size of 100 mesh. Plasma treatment was performed at 100 watts for 20 minutes to obtain a powder with a specific surface area of ​​8.1 square meters per gram. 150 parts by weight of menthol and 220 parts by weight of β-cyclodextrin were encapsulated using a gradient temperature program. 120 parts by weight of patchouli, 50 parts by weight of clove, 100 parts by weight of Angelica dahurica, and 110 parts by weight of Amomum tsao-ko were dried at 60°C for 8 hours and then pulverized. 5 parts by weight of polylactic acid microspheres (pre-etched with 0.2 mol / L sodium hydroxide for 30 minutes, particle size 80 micrometers) were added during compounding. Example 3

[0040] In this embodiment, the similarities to those in Embodiment 1 will not be repeated, and the differences are as follows: Take 150 parts by weight of Artemisia argyi, 90 parts by weight of cinnamon, 100 parts by weight of Atractylodes lancea, and 130 parts by weight of Acorus tatarinowii, and dry them at 45 degrees Celsius to a moisture content of 7.0%. Grind at 22 degrees Celsius to a particle size of 85 mesh. Plasma treatment at 125 watts for 15 minutes resulted in a specific surface area of ​​8.5 square meters per gram. Inclusion treatment of 130 parts by weight of menthol and 260 parts by weight of β-cyclodextrin (as before). 140 parts by weight of patchouli, 55 parts by weight of clove, 120 parts by weight of Angelica dahurica, and 130 parts by weight of Amomum tsao-ko were dried at 62 degrees Celsius for 7 hours and then ground. 10 parts by weight of polylactic acid microspheres were added (etched with 0.15 mol / L sodium hydroxide for 45 minutes to a particle size of 65 micrometers).

[0041] In this comparative example, the similarities with Example 1 will not be repeated, and the differences are as follows: The plasma treatment was cancelled, and the base powder (specific surface area of ​​3.2 square meters per gram) was used directly.

[0042] In this comparative example, the similarities with Example 2 will not be repeated, and the differences are as follows: The inclusion process is kept at a constant temperature of 45 degrees Celsius, and the gradient temperature increase is eliminated.

[0043] In this comparative example, the similarities with Example 3 will not be repeated, and the differences are as follows: Irradiation was performed using a uniform dose of 12,000 Gy, and zonal control was eliminated.

[0044] In this comparative example, the similarities with Example 1 will not be repeated, and the differences are as follows: No diatomaceous earth slow-release carrier is added during compounding.

[0045] In this comparative example, the similarities with Example 1 will not be repeated, and the differences are as follows: The polylactic acid microspheres were not etched with sodium hydroxide.

[0046] Products were prepared according to the parameters of the examples and comparative examples, and their performance was tested. Specifically, the aroma dissipation time was determined using GB / T 23818-2009, the aroma intensity retention rate was tested using ISO 27971:2008, the cinnamaldehyde content was determined using the 2020 edition of the Chinese Pharmacopoeia, microbial testing was performed using GB 15979-2002, and the clumping rate was measured using ASTM D6393. The test results are shown in Table 1.

[0047] As shown in Table 1, after eliminating the plasma treatment in Comparative Example 1, the specific surface area decreased to 3.2 square meters per gram, resulting in an increase in the agglomeration rate to 28.6% and a 46% reduction in aroma dissipation time. This confirms the significance of surface modification to form nano-pits in the technical solution: pit structures with a depth of 100 to 200 nanometers and a diameter of 0.5 to 1.5 micrometers significantly improve powder carrying capacity, allowing volatile components to adhere uniformly. The specific ratio of pit depth to diameter creates an optimal capillary effect, slowing down the diffusion rate of aroma molecules while maintaining high-intensity release.

[0048] In Comparative Example 2, when isothermal inclusion was used, the cinnamaldehyde retention rate decreased to 87.6%, and the aroma intensity loss reached 15.7%. This is because the gradient heating program controls the molecular self-assembly rate, avoiding molecular chain breakage caused by local overheating. Especially in the initial stage at 40 degrees Celsius, menthol and β-cyclodextrin slowly form a hydrogen bond network, protecting the spatial structure integrity of the heat-sensitive components.

[0049] Comparative Example 3 showed that uniform irradiation resulted in residual microorganisms in the middle layer due to damage to surface active ingredients caused by high-dose zones. This proposed solution employs a zoned dose gradient design: a high dose in the upper layer rapidly kills surface microorganisms, a high dose in the middle layer enhances sterilization penetration, and a low dose in the lower layer protects deposited components. This strategy maintains a 99.9% sterilization rate while reducing heat-sensitive loss by more than 5 percentage points.

[0050] Table 1 Analysis of Test Results Group Scent dissipation time (h) Initial aroma intensity (%) Cinnamaldehyde retention rate (%) Total bacterial count (CFU / g) clumping rate (%) Example 1 126 94.2 97.8 <10 4.1 Example 2 118 92.7 96.3 <10 4.9 Example 3 122 93.5 97.1 <10 4.3 Comparative Example 1 68 91.4 95.2 850 28.6 Comparative Example 2 104 84.3 87.6 <10 5.2 Comparative Example 3 115 90.1 92.3 120 4.8 Comparative Example 4 97 93.8 96.9 <10 13.7 Comparative Example 5 89 91.2 95.8 <10 17.3 In Comparative Example 4, without diatomaceous earth, the clumping rate reached 13.7%, and the fragrance dissipation time was shortened by 23%. Diatomaceous earth and polylactic acid microspheres (the effect was weakened in Comparative Example 5 without etching) formed a physical barrier layer, whose microporous structure adsorbed volatile components, forming a secondary release source. In particular, the polylactic acid microspheres etched with sodium hydroxide formed pores of 50 to 100 nanometers on their surface, triggering a moisture absorption and expansion release mechanism when the ambient humidity exceeded 60%, thus prolonging the effective action time.

[0051] This application employs a three-stage speed-regulating strategy to address component segregation caused by density differences through shear force gradient changes. Patchouli powder and diatomaceous earth are initially mixed at low speed, penetration is enhanced at medium speed, and stable distribution is achieved at the final speed, keeping the aroma component distribution difference within 5%. This application systematically solves the problems pointed out in the prior art, such as the trade-off between aroma intensity and duration, and the mutual constraints between component loss and sterilization requirements, significantly improving the fragrance dissipation time compared to existing technologies.

[0052] The above description represents the preferred embodiments of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A method for preparing a long-lasting, aromatic traditional Chinese medicine composition fragrance, characterized in that, The preparation method includes the following steps: (1) Raw material pretreatment: Take 120-180 parts by weight of Artemisia argyi, 90-120 parts by weight of cinnamon, 85-120 parts by weight of Atractylodes lancea, and 110-150 parts by weight of Acorus tatarinowii, dry them, and obtain primary dried material; (2) Ultrafine grinding: The primary dried material is ground to obtain the basic powder; (3) Surface modification: The base powder is subjected to plasma surface modification treatment to obtain activated powder with a specific surface area greater than 8.0 m² / g; (4) Preparation of sustained-release agent: Weigh 110-150 parts by weight of menthol and 220-300 parts by weight of β-cyclodextrin, add deionized water to form a suspension, stir in a water bath, filter and dry to obtain the inclusion complex, and the obtained inclusion complex is the sustained-release agent; (5) Compound mixing: Add 120-160 parts by weight of patchouli, 50-65 parts by weight of clove, 100-140 parts by weight of angelica dahurica and 110-150 parts by weight of cardamom powder to the activated powder, then add the inclusion complex and mix to form a mixture; (6) Irradiation sterilization: The mixture is transported to an electron accelerator irradiation field for irradiation to obtain the final product of a traditional Chinese medicine composition fragrance with long-lasting fragrance.

2. The method for preparing a functional, long-lasting, aromatic traditional Chinese medicine composition fragrance according to claim 1, characterized in that, In step (2), an air jet mill is used for pulverization, and the air pressure of the air jet mill is 0.65 MPa.

3. The method for preparing a functional, long-lasting, aromatic traditional Chinese medicine composition fragrance according to claim 1, characterized in that, The specific steps of step (3) are as follows: place the base powder in a plasma device, introduce argon gas to replace the air, and perform plasma surface modification treatment at a power of 100-150 watts for 10-20 minutes to obtain activated powder with nanoscale pits formed on the surface. The pits are 100-200 nanometers deep and 0.5-1.5 micrometers in diameter.

4. The method for preparing a functional, long-lasting, aromatic traditional Chinese medicine composition fragrance according to claim 3, characterized in that, The plasma surface modification treatment uses a 5000 Hz pulse mode, with a single pulse duration of 0.1 milliseconds and a duty cycle of 60%.

5. The method for preparing a functional, long-lasting, aromatic traditional Chinese medicine composition fragrance according to claim 1, characterized in that, In step (5), the patchouli, cloves, angelica, and cardamom need to be dried at 60-65 ℃ for 6-8 hours before being pulverized and passed through an 80-mesh sieve.

6. The method for preparing a functional, long-lasting, aromatic traditional Chinese medicine composition fragrance according to claim 1, characterized in that, In step (5), 5-15 parts by weight of a slow-release carrier are added during compounding. The slow-release carrier is polylactic acid microspheres or diatomaceous earth.

7. The method for preparing a functional, long-lasting fragrance-dispersing traditional Chinese medicine composition fragrance according to claim 6, wherein the polylactic acid microspheres have a particle size of 50-80 micrometers, and the polylactic acid microspheres are pre-etched in a 0.1-0.2 mol / L NaOH solution for 30-60 minutes before being added.

8. According to the method for preparing a long-lasting fragrance-dispersing traditional Chinese medicine composition fragrance according to claim 1, in the water bath stirring process of step (4), a gradient heating program is adopted: maintaining 40°C for the first 30 minutes, and then raising it to 45°C at a rate of 0.5°C per minute and maintaining it for 90 minutes.

9. According to claim 1, the method for preparing a long-lasting fragrance-dispersing traditional Chinese medicine composition fragrance, step (5) involves adjusting the speed in stages during mixing: running at 100 revolutions per minute for the first 10 minutes, increasing to 200 revolutions per minute for the middle 10 minutes, and decreasing back to 150 revolutions per minute for the last 10 minutes.

10. According to claim 1, the method for preparing a long-lasting fragrance-dispersing traditional Chinese medicine composition fragrance, in step (6) irradiation, zonal dose control is implemented: the upper layer of the material receives 10000 Gy, the middle layer 12000 Gy, and the lower layer 8000 Gy.