Sample management device and sampling method

Abstract

The invention relates to the technical field of medical instruments, in particular to a sample management device and a sampling method. The device comprises a supporting bottom plate, a placing plate, a partition plate and a sampling mechanism, the placing plate and the supporting bottom plate are arranged in parallel at intervals; the multiple partition plates are connected to the placement plate and are arranged in parallel at intervals in the first direction, and placement grooves suitable for containing sample frames are formed between the adjacent partition plates; the sampling mechanism is slidably connected with the supporting bottom plate and located on one side of the containing plate, the sampling mechanism can be controlled to slide in the first direction, the sampling mechanism is used for transferring the sample frame in the containing groove, the sampling mechanism is provided with two first detection assemblies and two second detection assemblies, the first detection assemblies are used for detecting whether the sample frame completely enters the sampling mechanism or not, and the second detection assemblies are used for detecting whether the sample frame completely enters the sampling mechanism. The detection directions of the two second detection assemblies intersect, and the two second detection assemblies are used for detecting samples on the sample frame. The overall detection efficiency and the system automation level can be improved.

Description

A sample management device and sampling method Technical Field

[0001] This application relates to the field of medical device technology, specifically to a sample management device and sampling method. Background Technology

[0002] Currently, in vitro diagnostic equipment is widely used in the medical field, and specific protein analyzers are key devices for accurately determining protein content and structure. They are widely applied in disease diagnosis, treatment monitoring, and prognostic assessment. For example, through quantitative and qualitative analysis of specific proteins (such as the inflammatory marker C-reactive protein, the cardiac marker troponin, and the tumor marker carcinoembryonic antigen) in blood, body fluids, or tissue samples, they provide doctors with crucial diagnostic information. However, existing specific protein analyzers still have many shortcomings in sample management.

[0003] Existing specific protein analyzers cannot achieve batch storage and fully automated sample transport, making it difficult to meet the demands of high-throughput detection. Furthermore, the stability and accuracy of samples during transport need improvement, as issues such as sample position deviation and transport delays may occur. Existing sample transport devices lack intelligent scheduling capabilities when dealing with multiple specific protein analyzers. When multiple sample racks need to be tested simultaneously, and different analyzers have different detection loads, the devices cannot allocate sample racks rationally according to the actual situation, resulting in some analyzers being idle while others are overloaded, thus reducing overall detection efficiency. Summary of the Invention

[0004] This application provides a sample management device and sampling method. By centrally storing a large number of sample racks and configuring multiple detection components for a driveable sampling mechanism to detect each sample rack, and combining the positioning logic of the sampling mechanism, the sampling mechanism can accurately align the target sample rack among a large number of sample racks, thereby realizing the sampling of the target sample rack. Sample racks are allocated to each analyzer to ensure that multiple analyzers can perform analysis work simultaneously and improve the overall detection efficiency.

[0005] This application is achieved through the following technical solution:

[0006] In a first aspect, this application provides a sample management device, comprising:

[0007] Support base plate;

[0008] A placement plate, wherein the placement plate is arranged parallel to and spaced apart from the supporting base plate;

[0009] A partition, multiple partitions are connected to the placement plate and arranged in parallel intervals along a first direction, with adjacent partitions forming a placement slot suitable for accommodating a sample rack;

[0010] A sampling mechanism is slidably connected to the supporting base plate and located on one side of the placement plate. The sampling mechanism can be controlled to slide along the first direction. The sampling mechanism is used to transfer the sample rack in the placement slot. The sampling mechanism has two first detection components and two second detection components. The first detection components are used to detect whether the sample rack is completely inserted into the sampling mechanism. The detection directions of the two second detection components intersect. The two second detection components are used to detect the sample on the sample rack.

[0011] In some optional embodiments, the sampling mechanism includes:

[0012] The mounting base is slidably connected to the supporting base plate, and the mounting base and the supporting base plate are also connected by a belt drive mechanism so that the mounting base can slide along the first direction under the drive of the belt drive mechanism;

[0013] A belt drive assembly is connected to the mounting base. The conveying surface of the belt drive assembly is flush with the bottom surface of the placement slot and is used to convey the sample rack in a second direction, wherein the second direction is parallel to the surface of the placement plate and intersects with the first direction.

[0014] A sample-dispensing assembly is connected to the mounting base and is used to move a sample rack from the bottom of the placement plate to the belt drive assembly.

[0015] The bottom of the placement groove is provided with an avoidance notch for avoiding the sample-dispensing component.

[0016] In some optional embodiments, the sampling component includes:

[0017] A first linear drive assembly is connected to the mounting base;

[0018] Mounting plate, which is connected to the first linear drive assembly to move along a second direction under the drive of the first linear drive assembly;

[0019] A second linear drive assembly is connected to the mounting plate;

[0020] A sample-shifting plate, which is connected to the second linear drive assembly to move in a direction perpendicular to the surface of the placement plate under the drive of the second linear drive assembly, the sample-shifting plate having a sample-shifting end adapted to pass through the clearance notch.

[0021] In some alternative embodiments, the first direction and the second direction are orthogonal.

[0022] In some alternative embodiments, the first linear drive component includes:

[0023] A first motor is connected to the mounting base;

[0024] A drive wheel, which is driven by the first motor;

[0025] A passive wheel, which is rotatably connected to the mounting base;

[0026] A timing belt, which is engaged in a transmission with the driving pulley and the driven pulley;

[0027] A drag plate, which is connected to the timing belt;

[0028] A first guide rail slider assembly is connected to the mounting base, wherein the slider of the first guide rail slider assembly is connected to the drag plate, and the second linear drive assembly is connected to the slider of the first guide rail slider assembly.

[0029] In some optional embodiments, the second linear drive component includes:

[0030] A second motor is connected to the mounting plate;

[0031] The second guide rail slider assembly is connected to the mounting plate, wherein the template plate is connected to the slider of the second guide rail slider assembly, and a drive rod is connected to the template plate;

[0032] A cam rod, one end of which is driven by the second motor to swing under the drive of the second motor, has a strip-shaped sliding hole on the cam rod, and the drive rod is located in the strip-shaped sliding hole.

[0033] In some alternative embodiments, the mounting base is connected to a first positioning sensor that is spaced apart in the sliding direction of the first guide rail slider assembly to detect the position of the second linear drive assembly.

[0034] In some alternative embodiments, the mounting plate is connected to second positioning sensors that are spaced apart in the sliding direction of the second guide rail slider assembly to detect the position of the template plate.

[0035] In some optional embodiments, the support base plate is provided with a plurality of detection plates equidistantly arranged along a first direction, and the sampling mechanism is connected to a sensor to detect the detection plates when the sampling mechanism moves along the first direction, wherein the spacing between adjacent detection plates is equal to the spacing between adjacent placement slots.

[0036] Secondly, this application provides a sample collection method, implemented based on any of the sample management devices described in the first aspect, comprising the following:

[0037] The driving sampling mechanism moves in the first direction;

[0038] Real-time monitoring of feedback signals from the first and second detection components;

[0039] When the feedback level of one of the second detection components changes once and continues for a predetermined time, and the feedback level of the other second detection component changes, the sampling mechanism is driven to transfer the sample holder.

[0040] Compared with the prior art, this application has the following advantages and beneficial effects:

[0041] The sample management device and sampling method provided in this application, through the cooperation of a supporting base plate, a placement plate with a placement slot, and a sliding sampling mechanism, realizes the batch orderly storage and fully automatic and accurate transportation of sample racks, effectively meeting the needs of high-throughput detection. The sampling mechanism integrates two first detection components and two second detection components intersecting in two detection directions, which can accurately identify the position of the sample rack and the samples on the sample rack respectively. Combined with the belt drive component and the sample picking component, it ensures the stability and positioning accuracy of the samples during the grasping and transportation process, avoiding position deviation and jamming problems. At the same time, the device can realize intelligent scheduling and dynamic allocation of sample racks of multiple analyzers through detection information, and rationally allocate samples according to the real-time load of each analyzer, thereby optimizing the detection process, reducing equipment idleness or overload, and improving the overall detection efficiency and system automation level. Attached Figure Description

[0042] To more clearly illustrate the technical solutions of the exemplary embodiments of this application, the accompanying drawings used in the embodiments will be briefly described below. It should be understood that the following drawings only show some embodiments of this application and should not be considered as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort. In the drawings:

[0043] Figure 1 is a schematic diagram of the sample management device provided in an embodiment of this application;

[0044] Figure 2 is a schematic diagram of the sampling mechanism structure provided in an embodiment of this application;

[0045] Figure 3 is a schematic diagram of the sample assembly structure provided in an embodiment of this application;

[0046] Figure 4 is a schematic diagram of the structure of the first linear drive component provided in an embodiment of this application;

[0047] Figure 5 is a schematic diagram of the structure of the second linear drive component provided in an embodiment of this application;

[0048] Figure 6 is a schematic diagram of the placement plate structure provided in an embodiment of this application.

[0049] The attached diagram shows the markings and corresponding component names:

[0050] 100-Support base plate, 200-Placement plate, 201-Avoidance notch, 300-Partition plate, 400-Sampling mechanism, 401-Mounting base, 402-Belt drive assembly, 403-Sampling assembly, 4031-First linear drive assembly, 40311-First motor, 40312-Driving wheel, 40313-Passive wheel, 40314-Synchronous belt, 40315-First guide rail slider assembly, 40316-Supporting plate, 4032-Mounting plate, 4033-Second linear drive assembly, 40331-Second motor, 40332-Second guide rail slider assembly, 40333-Cam rod, 4034-Sampling plate, 40341-Drive rod, 500-Detection piece, 600-First detection assembly, 700-Second detection assembly. Detailed Implementation

[0051] To make the objectives, technical solutions, and advantages of this application clearer, the following detailed description is provided in conjunction with the embodiments and accompanying drawings. The illustrative embodiments and descriptions of this application are only for explaining this application and are not intended to limit this application.

[0052] When the sampling mechanism takes samples from a large number of sample racks, the sample channel on the sampling mechanism needs to be accurately aligned with the sample rack so that when the sample rack is transferred into the sample channel of the sampling mechanism, the two sides of the sample rack can maintain a slight gap with the inner wall of the sample channel to prevent the sample rack from rubbing against the inner wall of the sample channel during the transfer. Therefore, the alignment accuracy between the sampling mechanism and the sample rack is particularly important.

[0053] As shown in Figure 1, this application embodiment provides a sample management device, which includes a support base plate 100, a placement plate 200, a partition plate 300, and a sampling mechanism 400.

[0054] The support base plate 100 can be designed as a square plate. The support base plate 100 can be equipped with a support frame to keep the support base plate 100 at a certain height, so as to facilitate collaborative work with other equipment.

[0055] The placement plate 200 is connected to the support frame. The placement plate 200 and the support base plate 100 are arranged in parallel and spaced apart. The placement plate 200 can also be designed as a square plate. The surface area of ​​the placement plate 200 is smaller than the surface area of ​​the support base plate 100. In the working state, the placement plate 200 is located above the support base plate 100. In this embodiment, for ease of description, the length direction of the placement plate 200 is defined as the first direction.

[0056] There are multiple partitions 300 connected to the placement plate 200. The surface of each partition 300 is perpendicular to the surface of the placement plate 200. All the partitions 300 are arranged in parallel at intervals along the first direction. A placement groove suitable for accommodating the sample rack is formed between adjacent partitions 300. The width of the placement groove is slightly larger than the width of the sample rack. A baffle is connected to the part of the placement plate 200 located on one side of the placement groove along the length direction to limit the sample rack in the first direction. In this embodiment, for ease of description, the length direction of the placement groove is defined as the second direction. The first direction and the second direction are orthogonal.

[0057] The sampling mechanism 400 is slidably connected to the supporting base plate 100 and located on one side of the placement plate 200. In the second direction, the sampling mechanism 400 and the baffle are located on both sides of the partition plate 300. The sampling mechanism 400 can be controlled to slide along the first direction. For example, a drive mechanism can be configured for the sampling mechanism 400. The sampling mechanism 400 slides along the first direction under the drive of the drive mechanism. These drive mechanisms include, but are not limited to, ball screw transmission mechanisms, synchronous belt 40314 transmission mechanisms, gear and rack transmission mechanisms, etc. Thus, during the sliding process along the first direction, the sampling mechanism 400 is positioned by the drive mechanism or a sensor, and can correspond to the position of the sample rack in the placement slot in the second direction. The sampling mechanism 400 is used to transfer the sample rack in the placement slot. The sampling mechanism 400 has two first detection components 600 and two second detection components 700. The first detection components 600 are used to detect whether the sample rack is completely inserted into the sampling mechanism 400. For example, the two first detection components 600 are arranged at intervals, and the interval is equal to the length of the sample rack. The detection directions of the two second detection components 700 intersect. The two second detection components 700 are used to detect the sample on the sample rack. The detection directions of the two second detection components 700 form an angle with the second direction. Before the sampling mechanism 400 reaches the target position, one of the second detection components 700 can detect the target sample first.

[0058] In this embodiment of the application, the second detection component 700 is not only used to detect samples on the sample rack, but also to scan information such as barcodes on the samples. For example, the second detection component 700 may integrate a sensor and a scanner, with the scanner in one second detection component 700 used to scan information on the sample rack, and the scanner in another second detection component 700 used to scan information on the samples on the sample rack.

[0059] In some optional embodiments, referring to Figures 2 and 6 together, the sampling mechanism 400 includes a mounting base 401, a belt drive assembly 402, and a sample feeding assembly 403. The mounting base 401 is slidably connected to the supporting base plate 100. In actual implementation, the mounting base 401 can be designed as an L-shaped plate. The shorter plate portion of the mounting base 401 can be connected to the supporting base plate 100 via a guide rail slider mechanism. The surface of the longer plate portion of the mounting base 401 is perpendicular to the surface of the supporting base plate 100. The mounting base 401 and the supporting base plate 100 are also connected by a belt drive mechanism to slide along a first direction under the drive of the belt drive mechanism. The belt drive assembly 402 is connected to the mounting base 401. The conveying surface of the belt drive assembly 402 is flush with the bottom surface of the placement slot and is used to convey the sample rack in a second direction. The second direction is parallel to the surface of the placement plate 200. In other embodiments, the second direction may also form an angle with the first direction. The sample-pushing component 403 is connected to the mounting base 401. The sample-pushing component 403 is used to push the sample rack from the bottom of the placement plate 200 to the belt drive component 402. The bottom of the placement groove is provided with a clearance notch 201 for avoiding the sample-pushing component 403.

[0060] In this embodiment, the sample holder is moved by the sample-moving component 403 so that the bottom of the sample holder comes into contact with the conveying surface in the belt drive component 402. Then, the position of the sample holder is changed by the transmission action of the belt drive component 402 so that the sample holder is in a specific position of the sampling mechanism 400. The sample holder and the belt drive component 402 remain relatively stationary, thereby stabilizing the posture of the sample holder and facilitating the sampling mechanism 400 to transfer the sample holder to other devices.

[0061] In some optional embodiments, referring together to Figures 3 to 5, the sample-setting component 403 includes a first linear drive component 4031, a mounting plate 4032, a second linear drive component 4033, and a sample-setting plate 4034.

[0062] The first linear drive assembly 4031 is connected to the mounting base 401. The first linear drive assembly 4031 can be configured as a guide rail slider mechanism driven by a belt drive structure. In actual implementation, the first linear drive assembly 4031 may include a first motor 40311, a driving wheel 40312, a driven wheel 40313, a synchronous belt 40314, a drag plate 40316, and a first guide rail slider assembly 40315; the first motor 40311 is connected to the mounting base 401; the driving wheel 40312 is connected to the first guide rail slider assembly 40315. A motor 40311 is engaged in transmission; a driven wheel 40313 is rotatably connected to a mounting base 401; a synchronous belt 40314 is engaged in transmission with a driving wheel 40312 and a driven wheel 40313; a drag plate 40316 is connected to the synchronous belt 40314; a first guide rail slider assembly 40315 is connected to the mounting base 401, wherein the slider of the first guide rail slider assembly 40315 is connected to the drag plate 40316, and a second linear drive assembly 4033 is connected to the slider of the first guide rail slider assembly 40315.

[0063] Mounting plate 4032 can be designed as an L-shaped plate. The long plate of mounting plate 4032 is connected to the slider of the first linear drive assembly 4031 so as to move along the second direction under the drive of the first linear drive assembly 4031.

[0064] The second linear drive assembly 4033 is connected to the mounting plate 4032, so that the second linear drive assembly 4033 will move synchronously under the drive of the slider of the first guide rail slider assembly 40315. Specifically, the second linear drive assembly 4033 may include a second motor 40331, a second guide rail slider assembly 40332, and a cam rod 40333. The second motor 40331 is connected to the short plate of the mounting plate 4032, and the output shaft of the second motor 40331 moves through the short plate. The second guide rail slider assembly 40332 is connected to the mounting plate 4032, and the second guide rail slider assembly 40332 and the second motor 40331 are located on both sides of the thickness direction of the short plate. The sample plate 4034 is connected to the slider of the second guide rail slider assembly 40332, and a drive rod 40341 ​​is connected to the sample plate 4034. One end of the cam rod 40333 is in transmission cooperation with the second motor 40331. Driven by the second motor 40331, the cam rod 40333 has a strip-shaped sliding hole, and the drive rod 40341 ​​is located in the strip-shaped sliding hole. When the cam rod 40333 swings under the drive of the second motor 40331, the drive rod 40341 ​​will slide in the strip-shaped sliding hole. The cam rod 40333 will drive the sample-dispensing plate 4034 to move on the second guide rail slider assembly 40332. The sample-dispensing plate 4034 has a sample-dispensing end suitable for passing through the avoidance notch 201. The sample-dispensing end is initially located below the placement plate 200. When the sample-dispensing plate 4034 is driven by the second motor 40331, the sample-dispensing end will pass through the avoidance notch 201 and enter the groove at the bottom of the sample holder. Then, driven by the first motor 40311, the sample-dispensing plate 4034 moves in the second direction, which can push the sample holder so that one end of the sample holder in the length direction contacts the synchronous belt 40314 in the sampling mechanism 400.

[0065] In some alternative embodiments, a first positioning sensor, spaced apart in the sliding direction of the first guide rail slider assembly 40315, is connected to the mounting base 401 to detect the position of the second linear drive assembly 4033.

[0066] In actual implementation, there are two first positioning sensors, which are arranged at intervals along the second direction. The two first positioning sensors correspond to the starting and ending positions of the push plate 4034, respectively. An L-shaped baffle can be connected to the drag plate 40316 for detection by the two first positioning sensors.

[0067] In some alternative embodiments, the mounting plate 4032 is connected to second positioning sensors that are spaced apart in the sliding direction of the second guide rail slider assembly 40332 to detect the position of the template plate 4034.

[0068] In actual implementation, there are two second positioning sensors. These two second positioning sensors are arranged at intervals along a direction perpendicular to the surface of the placement plate 200. These two second positioning sensors correspond to the initial position of the sample-dispensing plate 4034 and the position where the sample-dispensing end is inserted into the bottom groove of the sample holder, respectively. An L-shaped baffle can be connected to the sample-dispensing plate 4034 for detection by the two second positioning sensors.

[0069] In some optional embodiments, a plurality of detection plates 500 are provided on the support base plate 100, which are equidistantly arranged along a first direction. A sensor is connected to the sampling mechanism 400 to detect the detection plates 500 when the sampling mechanism 400 moves along the first direction. The spacing between adjacent detection plates 500 is equal to the spacing between adjacent placement slots.

[0070] In this embodiment, when the sensor on the sampling mechanism 400 detects the detection piece 500, it indicates that the sampling mechanism 400 is basically aligned with the sample rack in the placement slot. By combining the detection results of the first detection component 600 and the second detection component 700 and verifying them with each other, the sampling mechanism 400 can achieve high-precision positioning, thereby enabling the sampling mechanism 400 to accurately retrieve the target sample rack from a large number of sampling racks.

[0071] Secondly, based on the sample management device provided in the above embodiments, this application provides a sample sampling method.

[0072] Based on the sample management device provided in the above embodiments, its working principle and the positioning logic of the sampling mechanism 400 therein are described:

[0073] During system initialization, the sampling mechanism 400 is positioned in its initial state and is limited by a mechanical structure. The sampling mechanism 400 is accurately aligned with the first sample holder in the first direction. The sample-pulling plate 4034 on the sampling mechanism 400 moves under the drive of the second linear drive component 4033, causing the sample-pulling end to pass through the clearance notch 201 at the bottom of the placement slot and enter the groove at the bottom of the sample holder. Under the drive of the first linear drive component 4031, the sample-pulling plate 4034 pushes the sample holder to move in the second direction until one end of the sample holder in the length direction contacts the transmission surface of the belt drive component 402 on the sampling mechanism 400. Then, the sample holder is transmitted through the belt drive component 402 on the sampling mechanism 400. After that, the sampling mechanism 400 moves in the first direction to transmit the sample holder on it to the target analyzer, completing the automatic and intelligent scheduling of the sample holder. After the sampling mechanism 400 completes the transfer of the sample rack on it, the travel of the sampling mechanism 400 can be measured according to the number of feedback signals from the sensors on the sampling mechanism 400. Then, based on the extraction requirements and the number of feedback signals from the sensors on the sampling mechanism 400, the sampling mechanism 400 is positioned at the target sample rack position to achieve intelligent scheduling. When the sampling mechanism 400 is positioned near the target sample rack, it is driven to move along a first direction. The feedback signal of the sensor in one of the second detection components 700 is low level, high level, low level, where the high level lasts for a predetermined time. At the instant the high level changes to the low level, the feedback signal of the sensor in the other second detection component 700 changes from low level to high level, indicating that the sample on the target sample rack has been detected. Then, the sampling mechanism 400 is retracted so that the sensors in both second detection components 700 return a high level. At this time, the sampling mechanism 400 can be accurately aligned with the target placement slot, and then the sample rack can be transferred.

[0074] In the above positioning logic, the sampling mechanism 400 is equivalent to moving a short distance past the target position and then retreating back to the target position. The purpose of doing this is to ensure that the samples detected by the two second detection components 700 are the target samples, thus ensuring the accuracy of the detection. In addition, by calculating the feedback time of the sensor in one of the second detection components 700, the diameter of the sample being tested can be determined, thus avoiding the removal of samples placed in the wrong direction.

[0075] In the above positioning logic, at the instant when the sensor in one of the second detection components 700 changes from high level to low level, the feedback signal of the sensor in the other second detection component 700 changes from low level to high level, which means that the detection directions of the sensors in the two second detection components 700 can be simultaneously tangent to the radial sides of the sample.

[0076] Based on the above working principle and the positioning logic of the sampling mechanism 400, the sample sampling method includes:

[0077] The driving sampling mechanism 400 moves in the first direction.

[0078] The sampling mechanism 400 can be controlled by a PLC configured separately as a lower-level machine, or it can be controlled by the protein analysis system.

[0079] Real-time monitoring of feedback signals from sensors in the first detection component 600 and the second detection component 700;

[0080] When the feedback level of one of the second detection components 700 changes once and continues for a predetermined time, and the feedback level of the other second detection component 700 changes, the sampling mechanism 400 is driven to transfer the sample holder.

[0081] The specific embodiments described above illustrate the implementation of this application. Those skilled in the art can easily understand other advantages and effects of this application from the content disclosed in this specification. Although the description of this application is presented in conjunction with some embodiments, this does not mean that the features of this application are limited to this embodiment. On the contrary, the purpose of describing the application in conjunction with embodiments is to cover other options or modifications that may be derived based on the claims of this application. To provide a thorough understanding of this application, many specific details are included in the above description. This application may also be implemented without using these details. Furthermore, to avoid confusion or obscuring the focus of this application, some specific details will be omitted in the description. It should be noted that, unless otherwise specified, the embodiments and features in the embodiments of this application can be combined with each other.

[0082] It should be noted that in this specification, similar reference numerals and letters in the above figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures. In the description of this application, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the figures, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on this application. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance. In the description of this application, it should be noted that unless otherwise expressly specified and limited, the terms "installed," "connected," and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal communication between two elements. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0083] Obviously, those skilled in the art can make various modifications and variations to this application without departing from the spirit and scope of this application. Therefore, if such modifications and variations fall within the scope of the claims of this application and their equivalents, this application also intends to include such modifications and variations.

Claims

1. A sample management device, characterized in that, include: Support base plate (100); placement plate (200), wherein the placement plate (200) is arranged parallel to and spaced apart from the support base plate (100); A partition (300) is connected to the placement plate (200) and arranged parallel to each other along a first direction, forming a placement groove suitable for accommodating a sample rack between adjacent partitions (300); a sampling mechanism (400) is slidably connected to the support base plate (100) and located on one side of the placement plate (200), the sampling mechanism (400) is controllably slidable along the first direction, the sampling mechanism (400) is used to transfer the sample rack in the placement groove, the sampling mechanism (400) has two first detection components (600) and two second detection components (700), the first detection components (600) are used to detect whether the sample rack is completely inserted into the sampling mechanism (400), the detection directions of the two second detection components (700) intersect, and the two second detection components (700) are used to detect the sample on the sample rack.

2. The sample management device according to claim 1, characterized in that, The sampling mechanism (400) includes: a mounting base (401), which is slidably connected to the supporting base plate (100), and the mounting base (401) and the supporting base plate (100) are also connected by a belt drive mechanism to slide along the first direction under the drive of the belt drive mechanism; and a belt drive assembly (402), which is connected to the mounting base (401), and the conveying surface of the belt drive assembly (402) is flush with the bottom surface of the placement slot and is used to convey the sample rack in the second direction. The second direction is parallel to the surface of the placement plate (200) and intersects with the first direction; a sample-moving assembly (403) is connected to the mounting base (401), and the sample-moving assembly (403) is used to move the sample rack from the bottom of the placement plate (200) to the belt drive assembly (402); wherein, a clearance notch (201) for avoiding the sample-moving assembly (403) is provided on the bottom of the placement groove.

3. The sample management device according to claim 2, characterized in that, The first direction and the second direction are orthogonal.

4. The sample management device according to claim 2, characterized in that, The sample-dispensing assembly (403) includes: a first linear drive assembly (4031) connected to the mounting base (401); a mounting plate (4032) connected to the first linear drive assembly (4031) to move along a second direction under the drive of the first linear drive assembly (4031); a second linear drive assembly (4033) connected to the mounting plate (4032); and a sample-dispensing plate (4034) connected to the second linear drive assembly (4033) to move along a direction perpendicular to the surface of the placement plate (200) under the drive of the second linear drive assembly (4033), wherein the sample-dispensing plate (4034) has a sample-dispensing end adapted to pass through the clearance notch (201).

5. The sample management device according to claim 4, characterized in that, The first linear drive assembly (4031) includes: a first motor (40311) connected to the mounting base (401); a drive pulley (40312) drivingly engaged with the first motor (40311); a driven pulley (40313) rotatably connected to the mounting base (401); and a synchronous belt (40314) connected to the drive pulley (40312) and the driven pulley (40313). The drive wheel (40313) is engaged with the drive plate (40316), which is connected to the synchronous belt (40314); the first guide rail slider assembly (40315) is connected to the mounting base (401), wherein the slider of the first guide rail slider assembly (40315) is connected to the drive plate (40316), and the second linear drive assembly (4033) is connected to the slider of the first guide rail slider assembly (40315).

6. The sample management device according to claim 5, characterized in that, The mounting base (401) is connected to a first positioning sensor that is spaced apart in the sliding direction of the first guide rail slider assembly (40315) to detect the position of the second linear drive assembly (4033).

7. The sample management device according to claim 4, characterized in that, The second linear drive assembly (4033) includes: a second motor (40331) connected to the mounting plate (4032); a second guide rail slider assembly (40332) connected to the mounting plate (4032), wherein the template plate (4034) is connected to the slider of the second guide rail slider assembly (40332), and a drive rod (40341) is connected to the template plate (4034); and a cam rod (40333), one end of which is driven by the second motor (40331) to swing under the drive of the second motor (40331), and a strip-shaped sliding hole is provided on the cam rod (40333), and the drive rod (40341) is located in the strip-shaped sliding hole.

8. The sample management device according to claim 7, characterized in that, The mounting plate (4032) is connected to a second positioning sensor that is spaced apart in the sliding direction of the second guide rail slider assembly (40332) to detect the position of the template plate (4034).

9. The sample management device according to claim 1, characterized in that, The support base plate (100) is provided with a plurality of detection plates (500) arranged at equal intervals along a first direction. The sampling mechanism (400) is connected to a sensor to detect the detection plates (500) when the sampling mechanism (400) moves along the first direction. The spacing between adjacent detection plates (500) is equal to the spacing between adjacent placement slots.

10. A sample collection method, implemented based on the sample management device according to any one of claims 1 to 9, characterized in that, Includes the following: driving the sampling mechanism (400) to move in a first direction; real-time monitoring of the feedback signals of the first detection component (600) and the second detection component (700); when the feedback level of one of the second detection components (700) changes once and lasts for a predetermined time, and the feedback level of the other second detection component (700) changes, driving the sampling mechanism (400) to transfer the sample holder.

Images