Tumor in-vitro sample pretreatment device

Abstract

The invention belongs to the technical field of medical equipment, and particularly relates to a tumor in-vitro sample pretreatment device which comprises a mounting shell, and a cleaning part, a rotating part and a dewatering part are sequentially arranged in the mounting shell from top to bottom; the cleaning part can be used for performing low-temperature washing on the sample, removing substances on the surface of the sample and automatically discharging the sample into the dewatering part after the sample is washed; the upper end of the dewatering part is matched with a discharge port of the cleaning part, and the dewatering part can drive the sample to rotate to adsorb residual moisture on the outer edge of the sample after the sample is discharged by the cleaning part; after the sample is dehydrated, the rotating part drives the dehydrating part to rotate to discharge the sample. According to the invention, the anti-overflow groove of the cleaning part is matched with the liquid supply groove to accurately control liquid and discharge impurities, the worm and gear transmission of the rotating part and the arc-shaped track guarantee stable unfolding, and the elastic structure of the dewatering part efficiently absorbs water and dynamically adaptively discharges water, so that the whole process of sample pretreatment is efficient and reliable.

Description

Technical Field

[0001] This invention belongs to the field of medical device technology, specifically relating to a tumor ex vivo sample pretreatment device. Background Technology

[0002] Pretreatment of ex vivo tumor samples is a crucial preliminary step in tumor pathology research, clinical diagnosis, and molecular detection, directly impacting the accuracy of subsequent experimental data and the reliability of clinical decisions. In tumor research, ex vivo samples must undergo core steps such as washing (removing blood, tissue debris, and other impurities), dehydration (reducing residual liquid on the sample surface), and transfer (safely transferring the samples to subsequent processing stages). Deviations in any of these steps can lead to sample contamination, morphological damage, or loss of effective components, thereby affecting key analytical results such as pathological section observation and molecular marker detection.

[0003] However, traditional methods for preprocessing tumor samples outside the body have significant limitations.

[0004] Firstly, the cleaning process relies on manual operation or simple mechanical devices, resulting in insufficient precision in controlling the volume of cleaning solution: manual operation is easily affected by the operator's experience, and excessive cleaning solution may cause the sample to be scattered or overflow to contaminate the environment, while insufficient solution will lead to the residue of impurities; mechanical devices mostly use fixed flow rate liquid supply, which cannot be dynamically adjusted according to the size and type of sample, making it difficult to meet the cleaning needs of different samples.

[0005] Secondly, there are safety hazards in the sample transfer process: traditional devices mostly complete the transfer by tilting or mechanical pushing. Samples are easily stuck on the inner wall of the device due to collision, or splashing due to improper speed control, resulting in sample loss or cross-contamination. Summary of the Invention

[0006] The purpose of this invention is to provide a tumor ex vivo sample pretreatment device that can precisely control liquid and remove impurities through the cooperation of the anti-overflow tank and the liquid supply tank in the cleaning section, the worm gear transmission and arc trajectory of the rotating section to ensure smooth unfolding, and the elastic structure of the dehydration section to efficiently absorb water and dynamically adapt to discharge it, so as to achieve high efficiency and reliability of the entire sample pretreatment process.

[0007] The specific technical solution adopted by this invention is as follows: A tumor ex vivo sample pretreatment device includes a mounting housing, wherein a cleaning section, a rotating section and a dehydration section are arranged sequentially from top to bottom inside the mounting housing; The cleaning unit can perform low-temperature rinsing of the sample to remove substances from the sample surface, and can automatically discharge the sample into the dehydration unit after rinsing is completed. The upper end of the dehydration section is matched with the discharge port of the cleaning section. After the sample is discharged by the cleaning section, the dehydration section can drive the sample to rotate to absorb the water remaining on the outer edge of the sample. After the sample dehydration is complete, the rotating part drives the dehydration part to rotate and discharge the sample; The cleaning unit includes a support base, a support cover, a guide seat, a sliding seat, a drive screw, and a drive motor. The support base is fixedly connected to the interior of the mounting housing. The support cover is disposed at the lower end of the support base. The guide seat is fixedly connected to the interior of the mounting housing. The sliding seat is slidably disposed on the outer edge of the guide seat. The interiors of both the guide seat and the sliding seat are slidably connected to both sides of the support cover. The drive screw is rotatably disposed inside the sliding seat. The interior of the sliding seat is threadedly connected to the outer edge of the drive screw. The drive motor is fixedly connected to the interior of the mounting housing, and the output end of the drive motor is fixedly connected to one end of the drive screw.

[0008] In a preferred embodiment, an anti-overflow groove is provided on one side of the support seat, and a liquid supply groove is provided on the other side of the support seat, with the liquid supply groove and the anti-overflow groove being horizontally aligned.

[0009] In a preferred embodiment, a support mesh is provided at the upper end of the inside of the support cover, and a discharge hopper is provided at the lower end of the support cover. The drainage flow rate of the discharge outlet inside the discharge hopper is less than the liquid supply flow rate of the liquid supply tank.

[0010] In a preferred embodiment, limit rods are fixedly provided on both sides of the bearing cover, with the limit rods being arranged at different heights.

[0011] In a preferred embodiment, the guide seat has a first guide groove and a second guide groove inside. The first guide groove is slidably connected to a limiting rod at a higher position. The interior of the first guide groove has a vertical section and an inclined moving section arranged sequentially from top to bottom. The interior of the second guide groove is slidably connected to a limiting rod at a lower position. The interior of the second guide groove has a vertical section, an inclined moving section and an arc-shaped rotating section arranged sequentially from top to bottom.

[0012] In a preferred embodiment, the sliding seat has a first extrusion groove and a second extrusion groove inside. The first extrusion groove has a vertical limiting section and an inclined pushing section arranged sequentially from top to bottom. The interior of the first extrusion groove is slidably connected to the limiting rod at the higher position. The interior of the second extrusion groove is inclined and is slidably connected to the limiting rod at the lower position.

[0013] In a preferred embodiment, the rotating part includes a rotating frame, a sliding frame, a guide plate, a drive worm gear, a drive worm, and a torque motor. One end of the rotating frame is rotatably connected to the interior of the mounting housing, one end of the sliding frame is slidably connected to the interior of the rotating frame, the guide plate is fixedly connected to the interior of the mounting housing, and the interior of the guide plate is slidably connected to the other end of the sliding frame. The drive worm gear is fixedly connected to one end of the rotating frame, the outer edge of the drive worm meshes with the drive worm gear, the torque motor is fixedly connected to the interior of the mounting housing, and the output end of the torque motor is fixedly connected to the drive worm.

[0014] In a preferred embodiment, the guide plate has an expansion groove inside, the expansion groove being arc-shaped in general, and the interior of the expansion groove being slidably connected to the sliding frame.

[0015] In a preferred embodiment, the dewatering section includes a mounting box, a follower box, guide rollers, a connecting plate, a connecting bridge, a feeding seat, a winding seat, and a winding motor. The mounting box is disposed inside the rotating frame, and the follower box is disposed inside the sliding frame. The follower box and the mounting box are slidably connected. The guide rollers are rotatably disposed inside the mounting box and the follower box, respectively. The two ends of the connecting plate are fixedly connected to the mounting box and the follower box, respectively. The connecting bridge is disposed at the lower part of the connecting plate, and the two ends of the connecting bridge are slidably connected to the mounting box and the follower box, respectively. The feeding seat is rotatably disposed inside the follower box, and absorbent material is wound around the outer edge of the feeding seat. The winding seat is rotatably disposed inside the mounting box, and the absorbent material of the feeding seat passes through the connecting bridge and the connecting plate and is fixedly connected to the winding seat. The winding motor is fixedly disposed inside the follower box, and the output end of the winding motor is fixedly connected to the winding seat.

[0016] In a preferred embodiment, the connecting plate and the connecting bridge are arc-shaped as a whole, with the arc pointing towards the interior of the mounting box and the follower box, and the connecting plate and the connecting bridge are made of elastic material.

[0017] The technical effects achieved by this invention are as follows: This invention employs a horizontally aligned design between the anti-overflow tank and the supply tank in the cleaning section to achieve precise control of the cleaning fluid volume. The sample is submerged in the cleaning fluid supplied to the supply tank; as the fluid level rises to the anti-overflow tank, excess liquid and floating debris are discharged, preventing overflow and contamination of the device while continuously removing impurities from the sample surface through flow. The support net at the top of the support cap supports the sample, and the drainage flow rate of the discharge hopper at the bottom is less than the supply flow rate, allowing the cleaning fluid to gradually fill to the height of the anti-overflow tank, ensuring thorough discharge of impurities. The two limiting rods, one high and one low, cooperate with the guide seat and sliding seat to achieve a multi-stage opening action of "vertical separation → oblique translation → tilting rotation," ensuring the sample falls smoothly into the dehydration section, avoiding splashing or retention. This invention employs a rotating section with a meshing transmission structure of a driving worm gear and a driving worm, combined with the precise output of a torque motor. Utilizing the self-locking characteristics of the worm gear and worm, the rotating frame is prevented from automatically deflecting due to sample gravity or external forces, ensuring controllability of the rotation angle and speed. The arc-shaped unfolding groove of the guide plate provides trajectory constraints for the sliding frame. When the torque motor drives the rotating frame to rotate from horizontal to vertical, the sliding frame slides along the arc-shaped groove and extends from inside the rotating frame. Its extension action is synchronized with the rotation action of the rotating frame, avoiding jamming or misalignment, ensuring that the dehydration section unfolds smoothly with the rotating section, providing spatial support for sample discharge. This invention employs an arc-shaped elastic structure of the dehydration section via a connecting plate and a connecting bridge, forming a curved water absorption channel. As the sample moves with the absorbent material, it rolls due to gravity, contacting the absorbent material at different angles to fully absorb residual moisture, significantly improving dehydration efficiency compared to traditional static water absorption methods. The elastic connecting plate and connecting bridge are stretched and flattened when the rotating section unfolds, eliminating obstruction to the sample. When the dehydration section rotates to a vertical position with the rotating section, the sample slides down the straight channel under gravity and is discharged, avoiding retention. Furthermore, the structure of the mounting box sliding into the rotating frame and the follower box sliding into the sliding frame enables rapid assembly of the dehydration section and the rotating section. The electrical connection between the winding motor and the controller ensures the coordination of dehydration and rotation actions, guaranteeing the continuity of the pretreatment process. Attached Figure Description

[0018] Figure 1 This is an overall schematic diagram of an embodiment of the present invention; Figure 2 This is a schematic diagram of the overall internal structure of an embodiment of the present invention; Figure 3 This is an exploded view of the cleaning section according to an embodiment of the present invention; Figure 4 This is an exploded view of the rotating part in an embodiment of the present invention; Figure 5 This is a schematic diagram of the guide plate according to an embodiment of the present invention; Figure 6 This is an exploded view of the dehydration section of an embodiment of the present invention; Figure 7 This is a cross-sectional view of the dehydration section in the assembled state according to an embodiment of the present invention; Figure 8 This is a cross-sectional view of the dehydration section in a stretched state according to an embodiment of the present invention; Figure 9 This is a cross-sectional view of the support cover according to an embodiment of the present invention; Figure 10 This is a schematic diagram of the assembly of the bearing cover and the bearing seat according to an embodiment of the present invention; Figure 11 This is a schematic diagram showing the positions of the guide seat and sliding seat when the support cover and support seat are assembled according to an embodiment of the present invention; Figure 12This is a schematic diagram illustrating the vertical movement of the bearing cover and its separation from the bearing seat in an embodiment of the present invention; Figure 13 This is a schematic diagram showing the positions of the guide seat and sliding seat when the bearing cover is separated from the bearing seat according to an embodiment of the present invention; Figure 14 This is a schematic diagram of the oblique movement of the bearing cover in an embodiment of the present invention; Figure 15 This is a schematic diagram showing the positions of the guide seat and the sliding seat when the bearing cover moves obliquely according to an embodiment of the present invention; Figure 16 This is a schematic diagram of the inclined state of the bearing cover in an embodiment of the present invention; Figure 17 This is a schematic diagram of the positions of the guide seat and the sliding seat when the load is tilted according to an embodiment of the present invention.

[0019] The attached diagram lists the components represented by each number as follows: 1. Housing; 2. Cleaning section; 201. Support seat; 2011. Overflow preventer; 2012. Liquid supply tank; 202. Support cover; 2021. Support net; 2022. Discharge hopper; 2023. Limiting rod; 203. Guide seat; 2031. First guide groove; 2032. Second guide groove; 204. Sliding seat; 2041. First extrusion groove; 2042. Second extrusion groove; 205. Drive screw; 2 06. Drive motor; 3. Rotating part; 301. Rotating frame; 302. Sliding frame; 303. Guide plate; 3031. Unwinding groove; 304. Drive worm gear; 305. Drive worm; 306. Torque motor; 4. Dewatering part; 401. Mounting box; 402. Follower box; 403. Guide roller; 404. Connecting plate; 405. Connecting bridge; 406. Feeding seat; 407. Rolling seat; 408. Winding motor. Detailed Implementation

[0020] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0021] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.

[0022] Secondly, the term "an embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in a preferred embodiment" appearing in different places throughout this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that mutually excludes other embodiments.

[0023] Secondly, the present invention is described in detail with reference to the schematic diagrams. When detailing the embodiments of the present invention, for ease of explanation, the cross-sectional views illustrating the device structure may be partially enlarged, not according to the usual scale. Furthermore, the schematic diagrams are merely examples and should not limit the scope of protection of the present invention. In addition, actual fabrication should include three-dimensional spatial dimensions of length, width, and depth.

[0024] Please see Figures 1 to 17 As shown, the present invention provides a tumor ex vivo sample pretreatment device, including a mounting housing 1, wherein a cleaning section 2, a rotating section 3 and a dehydration section 4 are arranged sequentially from top to bottom inside the mounting housing 1; The cleaning unit 2 can rinse the sample at low temperature to remove substances from the sample surface. After the sample is rinsed, it can automatically discharge the sample into the dehydration unit 4. The upper end of the dehydration section 4 is matched with the discharge port of the cleaning section 2. After the sample is discharged by the cleaning section 2, the dehydration section 4 can drive the sample to rotate to absorb the water remaining on the outer edge of the sample. After the sample dehydration is completed, the rotating part 3 drives the dehydration part 4 to rotate and discharge the sample. The housing 1 houses a controller, which is electrically connected to the washing section 2, the rotating section 3, and the dehydration section 4. The cleaning unit 2 includes a support 201, a support cover 202, a guide seat 203, a sliding seat 204, a drive screw 205, and a drive motor 206. The support 201 is fixedly connected to the interior of the mounting housing 1. The support cover 202 is located at the lower end of the support 201. The guide seat 203 is fixedly connected to the interior of the mounting housing 1. The sliding seat 204 is slidably located on the outer edge of the guide seat 203. The interiors of both the guide seat 203 and the sliding seat 204 are slidably connected to both sides of the support cover 202. The drive screw 205 is rotatably located inside the sliding seat 204. The interior of the sliding seat 204 is threadedly connected to the outer edge of the drive screw 205. The drive motor 206 is fixedly connected to the interior of the mounting housing 1, and the output end of the drive motor 206 is fixedly connected to one end of the drive screw 205. The drive motor 206 is electrically connected to the controller.

[0025] Specifically, the sample to be processed is placed inside the carrier 201, and an external pumping device introduces low-temperature cleaning fluid into the carrier 201. The cleaning fluid in the carrier 201 rinses the sample. The cleaning fluid gradually fills the carrier 201 and is discharged from the carrier 201 and the carrier cover 202, removing impurities from the sample surface and thus cleaning the sample. After the sample is rinsed and the cleaning fluid inside the support seat 201 and the support cover 202 is completely drained, the drive screw 205 is rotated by the drive motor 206. The rotation of the drive screw 205 causes the threaded sliding seat 204 to slide vertically on the outer edge of the guide seat 203, so that the sliding seat 204 presses the two sides of the support cover 202, causing the support cover 202 to gradually move and open at the lower end of the support seat 201 and rotate, so that the sample on the upper part of the support cover 202 falls into the dehydration section 4, thus realizing the discharge of the sample; After the sample is discharged from the washing section 2, it falls to the top of the dehydration section 4. At this time, the dehydration end of the dehydration section 4 is in a bent state, and the sample is inside the bend. Then the dehydration section 4 can drive the sample to rotate to adsorb the water remaining on the outer edge of the sample, thereby achieving the adsorption of water on the outer edge of the sample. After the sample is dehydrated, the rotating part 3 can drive the entire dehydration part 4 to rotate, so that the dehydration part 4 gradually extends. At this time, the extension of the dehydration part 4 can pull the dehydration end to gradually lengthen and change the depth of the dehydration end, so that the tilting of the dehydration part 4 can allow the sample to be discharged from the inside of the dehydration end, thus realizing the sample pretreatment.

[0026] Please see Figure 3 as well as Figures 10 to 17 As shown, an overflow prevention tank 2011 is provided on one side of the support 201, and a liquid supply tank 2012 is provided on the other side of the support 201. The liquid supply tank 2012 is connected to an external liquid supply device. The liquid supply tank 2012 and the overflow prevention tank 2011 are horizontally aligned. The cleaning solution is discharged into the interior of the support 201 through the interior of the liquid supply tank 2012 by the external liquid supply device to immerse the sample and realize the injection of cleaning solution. After the cleaning fluid is injected, the excess cleaning fluid is discharged through the inside of the anti-overflow tank 2011 after the liquid level reaches the anti-overflow tank 2011. This allows the debris floating on the surface of the cleaning fluid to be discharged through the inside of the anti-overflow tank 2011, preventing the cleaning fluid from overflowing into the bearing seat 201 and achieving control over the cleaning fluid level.

[0027] Please see Figure 9 As shown, a support net 2021 is provided at the upper end of the support cover 202, and a discharge hopper 2022 is provided at the lower end of the support cover 202. The drainage flow rate of the discharge outlet inside the discharge hopper 2022 is less than the liquid supply flow rate of the liquid supply tank 2012. After the cleaning liquid inside the liquid supply tank 2012 is discharged into the support seat 201, the cleaning liquid is discharged through the discharge hopper 2022, so that the impurities inside the cleaning liquid can be discharged through the discharge hopper 2022. Since the discharge flow rate inside the discharge hopper 2022 is less than the liquid supply of the liquid supply tank 2012, the cleaning liquid inside the support cover 202 gradually fills to the position of the anti-overflow tank 2011, thus realizing the discharge of impurities inside the cleaning liquid.

[0028] Please see Figure 9 As shown, limit rods 2023 are fixedly installed on both sides of the bearing cover 202. The limit rods 2023 are set at different heights, which can limit the load at multiple points and simplify the operation, providing support for the reliable installation and stable operation of the bearing cover 202.

[0029] Please see Figure 3 as well as Figures 10 to 17 As shown, the guide seat 203 has a first guide groove 2031 and a second guide groove 2032 inside. The first guide groove 2031 is slidably connected to the limiting rod 2023 at the higher position. The interior of the first guide groove 2031 is provided with a vertical section and an inclined moving section from top to bottom. The interior of the second guide groove 2032 is slidably connected to the limiting rod 2023 at the lower position. The interior of the second guide groove 2032 is provided with a vertical section, an inclined moving section and an arc-shaped rotating section from top to bottom. In the initial state, the lower end of the bearing cover 202 and the bearing seat 201 are joined together. As the sliding seat 204 moves downward in the guide seat 203, the sliding seat 204 presses the limiting rod 2023 to move first inside the vertical section of the first guide groove 2031 and the second guide groove 2032, so that the bearing cover 202 moves vertically and separates from the lower end of the bearing seat 201. Then the sliding seat 204 presses the limiting rod 2023 and slides into the removal section inside the first guide groove 2031 and the second guide groove 2032, causing the bearing cover 202 to move horizontally at an angle; Then, as the sliding seat 204 continues to move, the high-positioned limiting rod 2023 is limited to a stationary state inside the first guide groove 2031. The sliding seat 204 presses against the low-positioned limiting rod 2023. The low-positioned limiting rod 2023 is pressed by the sliding seat 204 and slides along the rotating section of the second guide groove 2032, causing the entire bearing cover 202 to rotate downward about the high-positioned limiting rod 2023 as the axis and enter an inclined state. The inclined bearing cover 202 causes the upper sample to be discharged and roll into the interior of the dehydration section 4.

[0030] Please see Figure 3 as well as Figures 10 to 17 As shown, the sliding seat 204 has a first extrusion groove 2041 and a second extrusion groove 2042 inside. The first extrusion groove 2041 has a vertical limiting section and an inclined pushing section arranged from top to bottom. The interior of the first extrusion groove 2041 is slidably connected to the limiting rod 2023 at the higher position. The interior of the second extrusion groove 2042 is set in an inclined shape. The interior of the second extrusion groove 2042 is slidably connected to the limiting rod 2023 at the lower position. The first extrusion groove 2041 cooperates with the first guide groove 2031. The lower limit rod 2023 is located at the intersection of the first extrusion groove 2041 and the first guide groove 2031, and the higher limit rod 2023 is located at the intersection of the second extrusion groove 2042 and the second guide groove 2032. In the initial state, the sliding seat 204 is at the upper end of the drive screw 205, and the limiting rods 2023 corresponding to the first extrusion groove 2041 and the second extrusion groove 2042 are both at the lower end of the first extrusion groove 2041 and the second extrusion groove 2042. During the downward movement of the sliding seat 204, firstly, the inclined pushing section of the first extrusion groove 2041 can drive the vertical section of the limiting rod 2023 inside the first guide groove 2031 to slide, and the interior of the second extrusion groove 2042 can drive the vertical section of the limiting rod 2023 inside the second guide groove 2032 to slide, thereby realizing the vertical sliding of the bearing cover 202. Then, as the sliding seat 204 continues to move downward, the inclined pushing section of the first extrusion groove 2041 can drive the limiting rod 2023 to slide obliquely in the moving section inside the first guide groove 2031, and the interior of the second extrusion groove 2042 can drive the limiting rod 2023 to slide in the moving section inside the second guide groove 2032, thereby realizing the parallel movement of the bearing cover 202. As the sliding seat 204 continues to move downward, the limiting segment of the first extrusion groove 2041 limits the corresponding limiting rod 2023 to the lower end of the moving segment of the first guide groove 2031, thereby limiting the limiting rod 2023 to the lower end of the moving segment of the first guide groove 2031. Then, the interior of the second extrusion groove 2042 squeezes the corresponding limiting rod 2023 to slide in the rotating segment inside the second guide groove 2032, causing the bearing cover 202 to gradually rotate and tilt so that the sample on the upper end of the bearing cover 202 can fall off.

[0031] Please see Figure 2 , Figure 4 and Figure 5 As shown, the rotating part 3 includes a rotating frame 301, a sliding frame 302, a guide plate 303, a drive worm gear 304, a drive worm 305, and a torque motor 306. One end of the rotating frame 301 is rotatably connected to the interior of the mounting housing 1, one end of the sliding frame 302 is slidably connected to the interior of the rotating frame 301, one end of the guide plate 303 is fixedly connected to the interior of the mounting housing 1, and the interior of the guide plate 303 is slidably connected to the other end of the sliding frame 302. The drive worm gear 304 is fixedly connected to one end of the rotating frame 301, the outer edge of the drive worm 305 meshes with the drive worm gear 304, the torque motor 306 is fixedly connected to the interior of the mounting housing 1, the output end of the torque motor 306 is fixedly connected to the drive worm 305, and the torque motor 306 is electrically connected to the controller. In the initial state, the rotating frame 301 is in a horizontal state, and the rotating frame 301 and the sliding frame 302 are in a spliced ​​state. The output end of the torque motor 306 drives the drive worm 305 to rotate. The rotation of the drive worm 305 drives the meshing drive worm wheel 304 to rotate. The rotation of the drive worm wheel 304 drives the rotating frame 301 to rotate. During the rotation of the rotating frame 301, one side of the sliding frame 302 slides inside the guide plate 303. At the same time, the sliding frame 302 slides out at the rotating frame 301 until the rotating frame 301 rotates to a vertical state. At this time, the sliding frame 302 is in the maximum extension state, realizing the state transformation of the rotating part 3 from "horizontal storage" to "vertical unfolding".

[0032] Please see Figure 2 , Figure 4 and Figure 5 As shown, the guide plate 303 has an expansion groove 3031 inside. The expansion groove 3031 is arc-shaped. The interior of the expansion groove 3031 is slidably connected to the sliding frame 302. In the initial state, the sliding frame 302 is at the upper end of the expansion groove 3031, and the rotating frame 301 and the sliding frame 302 are in a spliced ​​state. When the sliding frame 302 slides downward inside the expansion groove 3031, the sliding frame 302 gradually extends out of the interior of the rotating frame 301 until the rotating frame 301 drives the sliding frame 302 to a vertical state. At this time, the sliding frame 302 is in the maximum extension state. The arc-shaped structure of the unfolding groove 3031 provides a clear trajectory guide for the sliding frame 302. When the torque motor 306 of the rotating part 3 drives the rotating frame 301 to rotate from horizontal to vertical, the sliding frame 302 slides downward along the arc-shaped unfolding groove 3031. Its extension action from the rotating frame 301 is synchronized with the rotation action of the rotating frame 301, avoiding jamming or misalignment caused by chaotic trajectory, and ensuring that the dehydration part 4 unfolds smoothly with the rotating part 3.

[0033] Please see Figure 2 as well as Figures 6 to 8As shown, the dewatering section 4 includes a mounting box 401, a follower box 402, a guide roller 403, a connecting plate 404, a connecting bridge 405, a feeding seat 406, a winding seat 407, and a winding motor 408. The mounting box 401 is disposed inside the rotating frame 301, and the follower box 402 is disposed inside the sliding frame 302. The follower box 402 and the mounting box 401 are slidably connected. The guide roller 403 is rotatably disposed inside the mounting box 401 and the follower box 402, respectively. The two ends of the connecting plate 404 are fixedly connected to the mounting box 401 and the follower box 402, respectively. The connecting bridge 405... The connecting bridge 405 is located at the lower part of the connecting plate 404. Both ends of the connecting bridge 405 are slidably connected to the mounting box 401 and the follower box 402, respectively. The feeding seat 406 is rotatably located inside the mounting box 401. The outer edge of the feeding seat 406 is wound with absorbent material. The winding seat 407 is rotatably located inside the follower box 402. The absorbent material of the feeding seat 406 passes through the connecting bridge 405 and the connecting plate 404 and is fixedly connected to the winding seat 407. The winding motor 408 is fixedly located inside the follower box 402, and the output end of the winding motor 408 is fixedly connected to the winding seat 407. The dehydration unit 4 can be easily installed by sliding it into the interior of the rotating frame 301 and the sliding frame 302. After the dehydration unit 4 is installed inside the rotating frame 301 and the sliding frame 302, the winding motor 408 can be electrically connected to the controller inside the mounting housing 1. The structure of the dehydration unit 4 slidingly inserted into the rotating frame 301 through the mounting box 401 and the follower box 402 slidingly inserted into the sliding frame 302 enables the quick assembly of the dehydration unit 4 and the rotating unit 3, simplifying the maintenance and replacement process. At the same time, the electrical connection design between the winding motor 408 and the controller inside the mounting housing 1 ensures the coordinated control of the dehydration unit 4 and the whole device. After the sample is discharged from the cleaning unit 2, it falls into the interior of the bent absorbent material. Then, the rotation of the winding motor 408 drives the winding seat 407 to rotate. The rotation of the winding seat 407 winds up the absorbent material at the feeding seat 406, causing the absorbent material to slide between the bent connecting plate 404 and the connecting bridge 405. This causes the sample to move due to the movement of the absorbent material. Since the absorbent material at the connecting plate 404 and the connecting bridge 405 is bent, when the sample is carried to a higher position, it falls again due to its own gravity. This causes the sample to rotate at the absorbent material, so that the sample surface contacts the absorbent material at different angles, fully absorbing residual moisture and improving dehydration efficiency. As the rotating part 3 rotates downwards to open, the follower box 402 moves together with the sliding frame 302, causing the follower box 402 to slide open at the mounting box 401. The sliding of the follower box 402 causes the connecting plate 404 and the connecting bridge 405 to stretch, gradually flattening the curved state formed between the connecting plate 404 and the connecting bridge 405. At the same time, the dehydration part 4 rotates together with the rotating part 3, so that the dehydration part 4 is in a vertical state, and the connecting plate 404 and the connecting bridge 405 are in the maximum stretching state. This causes the dehydrated sample to fall out of the interior of the dehydration part 4 under the action of gravity, avoiding sample retention and ensuring the continuity and reliability of the pretreatment process, thereby completing the discharge of the sample by the dehydration part 4.

[0034] Please see Figure 2 as well as Figures 6 to 8 As shown, the connecting plate 404 and connecting bridge 405 are arc-shaped, with the arc pointing inwards towards the mounting box 401 and the follower box 402. The connecting plate 404 and connecting bridge 405 are made of deformable elastic material. This elasticity allows them to deform when the dehydration section 4 unfolds with the rotating section 3. When the torque motor 306 of the rotating section 3 drives the rotating frame 301 to rotate from a horizontal to a vertical position, the sliding frame 302 slides outwards within the arc-shaped unfolding groove 3031 of the guide plate 303, causing the follower box 402 to slide outwards along the mounting box 401, gradually increasing the distance between the mounting box 401 and the follower box 402. At this time, the elastic connecting plate 404 and connecting bridge 405 are stretched, gradually changing from an initial arc shape to a straight state, adapting to the change in distance through elastic deformation. This deformation not only prevents the rigid structure from breaking or jamming due to changes in spacing, but also straightens the channel between the connecting plate 404 and the connecting bridge 405 from a curved shape, reducing obstruction to the sample. The dehydrated sample, under the influence of gravity, can smoothly slide down the straight channel and be discharged, ensuring the continuity of the pretreatment process.

[0035] In summary, the arc-shaped structures of the connecting plate 404 and the connecting bridge 405 guide the rotation of the sample to achieve efficient dehydration, while the elastic material adapts to the unfolding process through dynamic deformation. The two work together to support the reliable realization of the "water absorption-discharge" function of the dehydration section 4.

[0036] The working principle of this invention is as follows: the sample to be processed is placed inside the support 201, and the external pump device introduces low-temperature cleaning fluid into the support 201. The cleaning fluid in the support 201 rinses the sample. The cleaning fluid gradually fills the inside of the support 201 and is discharged from the inside of the support 201 and the support cover 202, thereby removing impurities from the sample surface and cleaning the sample. After the sample is rinsed and the cleaning fluid inside the support seat 201 and the support cover 202 is completely drained, the drive screw 205 is rotated by the drive motor 206. The rotation of the drive screw 205 causes the threaded sliding seat 204 to slide vertically on the outer edge of the guide seat 203, so that the sliding seat 204 presses the two sides of the support cover 202, causing the support cover 202 to gradually move and open at the lower end of the support seat 201 and rotate, so that the sample on the upper part of the support cover 202 falls into the dehydration section 4, thus realizing the discharge of the sample; After the sample is discharged from the washing section 2, it falls to the top of the dehydration section 4. At this time, the dehydration end of the dehydration section 4 is in a bent state, and the sample is inside the bend. Then the dehydration section 4 can drive the sample to rotate to adsorb the water remaining on the outer edge of the sample, thereby achieving the adsorption of water on the outer edge of the sample. After the sample is dehydrated, the rotating part 3 can drive the entire dehydration part 4 to rotate, so that the dehydration part 4 gradually extends. At this time, the extension of the dehydration part 4 can pull the dehydration end to gradually lengthen and change the depth of the dehydration end, so that the tilting of the dehydration part 4 can allow the sample to be discharged from the inside of the dehydration end, thus realizing the sample pretreatment.

[0037] The above description is merely a preferred embodiment of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention. Structures, devices, and operating methods not specifically described or explained in this invention are implemented according to conventional methods in the art unless otherwise specified or limited.

Claims

1. A pretreatment device for ex vivo tumor samples, characterized in that: It includes a mounting housing (1), and the interior of the mounting housing (1) is provided with a cleaning section (2), a rotating section (3) and a dehydration section (4) from top to bottom. The cleaning section (2) can perform low-temperature rinsing of the sample to remove substances from the sample surface. After the sample rinsing is completed, the sample can be automatically discharged into the dehydration section (4). The upper end of the dehydration section (4) is matched with the discharge port of the cleaning section (2). After the sample is discharged by the cleaning section (2), the dehydration section (4) can drive the sample to rotate to adsorb the water remaining on the outer edge of the sample. After the sample dehydration is completed, the rotating part (3) drives the dehydration part (4) to rotate and discharge the sample; The cleaning unit (2) includes a support seat (201), a support cover (202), a guide seat (203), a sliding seat (204), a drive screw (205), and a drive motor (206). The support seat (201) is fixedly connected to the interior of the mounting housing (1). The support cover (202) is located at the lower end of the support seat (201). The guide seat (203) is fixedly connected to the interior of the mounting housing (1). The sliding seat (204) is slidably located on the outer edge of the guide seat (203). The interiors of both the guide seat (203) and the sliding seat (204) are slidably connected to both sides of the support cover (202). The drive screw (205) is rotatably located inside the sliding seat (204). The interior of the sliding seat (204) is threadedly connected to the outer edge of the drive screw (205). The drive motor (206) is fixedly connected to the interior of the mounting housing (1), and the output end of the drive motor (206) is fixedly connected to one end of the drive screw (205).

2. The tumor ex vivo sample pretreatment device according to claim 1, characterized in that: One side of the support (201) is provided with an overflow prevention groove (2011), and the other side of the support (201) is provided with a liquid supply groove (2012). The liquid supply groove (2012) and the overflow prevention groove (2011) are horizontally corresponding.

3. The tumor ex vivo sample pretreatment device according to claim 1, characterized in that: The upper end of the bearing cover (202) is provided with a bearing net (2021), and the lower end of the bearing cover (202) is provided with a discharge hopper (2022). The drainage flow rate of the discharge outlet inside the discharge hopper (2022) is less than the liquid supply flow rate of the liquid supply tank (2012).

4. The tumor ex vivo sample pretreatment device according to claim 1, characterized in that: Limiting rods (2023) are fixedly installed on both sides of the bearing cover (202), and the limiting rods (2023) are set at different heights.

5. The tumor ex vivo sample pretreatment device according to claim 1, characterized in that: The guide seat (203) has a first guide groove (2031) and a second guide groove (2032) inside. The first guide groove (2031) is slidably connected to the limiting rod (2023) at the higher position. The interior of the first guide groove (2031) is provided with a vertical section and an inclined moving section from top to bottom. The interior of the second guide groove (2032) is slidably connected to the limiting rod (2023) at the lower position. The interior of the second guide groove (2032) is provided with a vertical section, an inclined moving section and an arc-shaped rotating section from top to bottom.

6. The tumor ex vivo sample pretreatment device according to claim 1, characterized in that: The sliding seat (204) has a first extrusion groove (2041) and a second extrusion groove (2042) inside. The first extrusion groove (2041) has a vertical limiting section and an inclined pushing section arranged from top to bottom. The interior of the first extrusion groove (2041) is slidably connected to the limiting rod (2023) at the higher position. The interior of the second extrusion groove (2042) is set in an inclined shape. The interior of the second extrusion groove (2042) is slidably connected to the limiting rod (2023) at the lower position.

7. The tumor ex vivo sample pretreatment device according to claim 1, characterized in that: The rotating part (3) includes a rotating frame (301), a sliding frame (302), a guide plate (303), a drive worm gear (304), a drive worm (305), and a torque motor (306). One end of the rotating frame (301) is rotatably connected to the interior of the mounting housing (1), one end of the sliding frame (302) is slidably connected to the interior of the rotating frame (301), the guide plate (303) is fixedly connected to the interior of the mounting housing (1), the interior of the guide plate (303) is slidably connected to the other end of the sliding frame (302), the drive worm gear (304) is fixedly connected to one end of the rotating frame (301), the outer edge of the drive worm (305) meshes with the drive worm gear (304), the torque motor (306) is fixedly connected to the interior of the mounting housing (1), and the output end of the torque motor (306) is fixedly connected to the drive worm (305).

8. The tumor ex vivo sample pretreatment device according to claim 7, characterized in that: The guide plate (303) has an opening groove (3031) inside. The opening groove (3031) is arc-shaped and the interior of the opening groove (3031) is slidably connected to the sliding frame (302).

9. The tumor ex vivo sample pretreatment device according to claim 1, characterized in that: The dewatering section (4) includes a mounting box (401), a follower box (402), a guide roller (403), a connecting plate (404), a connecting bridge (405), a feeding seat (406), a winding seat (407), and a winding motor (408). The mounting box (401) is located inside the rotating frame (301), and the follower box (402) is located inside the sliding frame (302). The follower box (402) and the mounting box (401) are slidably connected. The guide roller (403) is rotatably located inside the mounting box (401) and the follower box (402), respectively. The two ends of the connecting plate (404) are fixedly connected to the mounting box (401) and the follower box (402), respectively. The connecting bridge... (405) is set at the lower part of the connecting plate (404). The two ends of the connecting bridge (405) are slidably connected to the mounting box (401) and the follower box (402) respectively. The feeding seat (406) is rotatably set inside the follower box (402). The outer edge of the feeding seat (406) is wound with water-absorbing material. The roll seat (407) is rotatably set inside the mounting box (401). The water-absorbing material of the feeding seat (406) passes through the connecting bridge (405) and the connecting plate (404) and is fixedly connected to the roll seat (407). The winding motor (408) is fixedly set inside the follower box (402), and the output end of the winding motor (408) is fixedly connected to the roll seat (407).

10. A tumor ex vivo sample pretreatment device according to claim 9, characterized in that: The connecting plate (404) and the connecting bridge (405) are arc-shaped as a whole, and the arc direction points to the interior of the mounting box (401) and the follower box (402). The connecting plate (404) and the connecting bridge (405) are made of elastic material.

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