Sample analyzer

Abstract

The embodiment of the invention provides a sample analyzer, comprising: a housing assembly comprising a face shell provided with an opening; the sample introduction mechanism comprises a sample seat and one or more baffles; a reaction device and a detection device; when the sample seat enters the inner part of the shell assembly from the outer part of the shell assembly through the opening or extends out of the outer part of the shell assembly from the inner part of the shell assembly through the opening, the one or more baffles open the opening; when the sample seat is located at a to-be-sucked sample position inside the shell assembly or the sample seat is located at a loading position outside the shell assembly, the one or more baffles shield the opening; the sample seat is located at the to-be-sucked sample position to place a sample container to be dispatched to the sample sucking position for sample sucking, and the sample seat is located at the loading position to receive the sample container loaded to the sample seat. By arranging one or more baffles to shield the opening of the face shell, the problems that pollution gas in the instrument leaks to the external environment and pollution gas in the external environment enters the instrument can be effectively reduced.

Description

Cross-references to related applications

[0001] This application is filed based on and claims priority to Chinese Patent Application No. 202411582011.5, filed on November 6, 2024, entitled “A Sample Analyzer”, the entire contents of which are incorporated herein by reference. Technical Field

[0002] This application relates to the field of in vitro diagnostic technology, and more particularly to a sample analyzer. Background Technology

[0003] In related technologies, some sample analyzers have strict anti-contamination standards, thus their structural design employs a partitioned layout. The sample area is one of the regions where the instrument interacts most frequently with the external environment and needs to remain open during sample introduction. However, this openness can lead to two problems during sample introduction: firstly, it may cause fluctuations in the pressure difference between the inside and outside of the sample analyzer, potentially interfering with the stability of the internal environmental conditions during sample detection; secondly, it may also lead to the leakage of contaminated gases from inside the instrument into the external environment, posing an exposure risk to the instrument operator, or contaminated gases from the external environment entering the instrument, affecting the accuracy of sample detection. Summary of the Invention

[0004] This application aims to provide a sample analyzer that reduces the leakage of polluting gases from inside the instrument to the external environment and the entry of polluting gases from the external environment into the instrument.

[0005] This application provides a sample analyzer, comprising: a housing assembly including a face shell with an opening; a sample injection mechanism including a sample holder and one or more baffles; the sample holder for holding a sample container for holding a sample to be tested; a reaction device for providing a reaction site for a mixed solution containing the sample to be tested and reagents in the reaction container and forming a reaction liquid; and a detection device for detecting the reaction liquid to obtain a detection result of the sample to be tested; wherein, when the sample holder enters the interior of the housing assembly from the outside through the opening, or extends from the interior of the housing assembly to the outside through the opening, the one or more baffles open the opening; when the sample holder is located at the sample aspiration position inside the housing assembly or at the loading position outside the housing assembly, the one or more baffles block the opening; the sample holder is located at the sample aspiration position to hold a sample container to be scheduled to the aspiration position for aspiration, and the sample holder is located at the loading position to receive a sample container loaded onto the sample holder.

[0006] In some embodiments, the sample delivery mechanism includes an unloading state; in the unloading state, the sample holder carries a sample container to be recycled and extends from the inside of the housing assembly to the outside of the housing assembly through the opening to transport the sample container to be recycled from the inside of the housing assembly to a recycling position outside the housing assembly; when the sample holder is located at the recycling position outside the housing assembly, the one or more baffles cover the opening.

[0007] In some embodiments, the interior of the housing assembly has a sample chamber with an air pressure lower than the external air pressure of the housing assembly.

[0008] In some embodiments, the sample analyzer further includes a sample dispensing component and a pipetting component disposed on the sample dispensing component. The sample dispensing component is used to move the pipetting component between different operating positions to aspirate or discharge the sample to be tested. The sample analyzer further includes a pressure detection mechanism and a processor. The pressure detection mechanism is used to detect the pressure inside the pipetting component, and the processor is used to receive the pressure signal output by the pressure detection mechanism and determine whether the pipetting component is leaking based on the pressure signal.

[0009] In some embodiments, the sample analyzer further includes a sample dispensing component and a pipetting component disposed on the sample dispensing component. The sample dispensing component is used to move the pipetting component between different operating positions to aspirate or discharge the sample to be tested. The sample analyzer also includes a dropper located below the pipetting component and moving with the pipetting component, for catching the sample to be tested dripping from the pipetting component.

[0010] In some embodiments, the sample analyzer further includes a scheduling mechanism, a clamping mechanism, a cap opening and closing mechanism, and a suction device; the scheduling mechanism is used to schedule the sample container to be suctioned on the sample holder to the cap opening position; the clamping mechanism is used to clamp or release the body of the sample container located in the cap opening position; the cap opening and closing mechanism is used to clamp the cap of the sample container located in the cap opening position to open or close the sample container; the suction device includes a suction port facing the opening of the body of the sample container located in the cap opening position.

[0011] In some embodiments, the one or more baffles include a first baffle and a second baffle; when the sample holder is located in the sample-to-absorption position inside the housing assembly, the first baffle blocks the opening and the second baffle avoids the opening; when the sample holder is located in the loading position outside the housing assembly, the second baffle blocks the opening and the first baffle avoids the opening.

[0012] In some embodiments, the second baffle is connected to and moves synchronously with the sample holder; during the movement of the sample injection mechanism from the inside of the housing assembly to the outside of the housing assembly, the second baffle and the sample holder move synchronously from the inside of the housing assembly toward the opening, and the first baffle moves to avoid the opening, so that the sample holder extends to the outside of the housing assembly and the second baffle blocks the opening; during the movement of the sample injection mechanism from the outside of the housing assembly to the inside of the housing assembly, the second baffle and the sample holder move synchronously from the opening toward the inside of the housing assembly, so that the sample holder and the second baffle enter the inside of the housing assembly, and the first baffle moves to block the opening.

[0013] In some embodiments, the inner surface of the faceplate has a sealing mating surface surrounding the opening, the sealing mating surface being used for sealing mating with the first baffle or the second baffle; the first baffle rotates relative to the faceplate, and the rotation center line of the first baffle is parallel to the sealing mating surface, so as to cover or avoid the opening.

[0014] In some embodiments, the rotational stroke of the first baffle is greater than 0° and does not exceed 90°.

[0015] In some embodiments, the inner surface of the shell has a sealing mating surface surrounding the opening, and the sealing mating surface is used to seal with the first baffle or the second baffle; the sample injection mechanism includes a driving mechanism for driving the first baffle to translate, the translational displacement of the first baffle including a displacement component in a first direction and a displacement component in a second direction; wherein, the first direction is perpendicular to the sealing mating surface, and the second direction is parallel to the sealing mating surface.

[0016] In some embodiments, the inner surface of the shell has a sealing mating surface surrounding the opening, the sealing mating surface being used for sealing mating with the first baffle or the second baffle; the sample holder and the second baffle move linearly along a first direction, the first direction being perpendicular to the sealing mating surface; the sample injection mechanism further includes a power mechanism for driving the sample holder and the second baffle to move linearly along the first direction.

[0017] In some embodiments, the sample introduction mechanism further includes a linkage mechanism for linking the first baffle and the second baffle, so that the first baffle moves to avoid the opening as the second baffle moves from the inside of the housing assembly to the opening, or the first baffle moves to block the opening as the second baffle moves from the opening to the inside of the housing assembly.

[0018] In some embodiments, the sample holder and the second baffle move linearly along a first direction; the sample injection mechanism further includes a shaft connected to the first baffle; the linkage mechanism includes a limiting member and a first reversing component, the movement of the second baffle and the sample holder drives the limiting member to move linearly along the first direction, and the first reversing component connects the limiting member and the shaft to convert the linear movement of the limiting member along the first direction into rotation of the shaft, thereby driving the first baffle to rotate through the shaft.

[0019] In some embodiments, the sample analyzer further includes a support platform and a shaft bracket; the first baffle, the second baffle, and the sample holder are all disposed on the top side of the support platform; the shaft bracket is connected to the support platform, and the shaft bracket has at least two shaft holes arranged coaxially in the height direction of the sample analyzer, and the shaft portion rotatably passes through the at least two shaft holes.

[0020] In some embodiments, the sample analyzer further includes a support platform and a track; the first baffle, the second baffle, and the sample holder are all disposed on the top side of the support platform; the track extends linearly along a first direction on the top surface of the support platform, and the track is used to guide the linear movement of the sample holder and / or the second baffle along the first direction.

[0021] In some embodiments, the linkage mechanism further includes an elastic element; the movement stroke of the second baffle and the sample holder in the first direction includes a first stroke segment and a second stroke segment, wherein the first stroke segment is located on the side closer to the interior of the housing assembly, and the second stroke segment is located on the side closer to the opening; in the first stroke segment, the elastic element applies a spring force to the limiting member in the direction close to the opening, and at least one of the sample holder and the second baffle abuts against the limiting member along the first direction under the action of the spring force, so that the second baffle, the sample holder, and the limiting member are linked; in the second stroke segment, the elastic element is in a natural state, and both the sample holder and the second baffle are separated from the limiting member, so that while the sample holder and the second baffle are moving, the linkage mechanism remains stationary.

[0022] In some embodiments, the first reversing assembly includes a ring-shaped first flexible transmission member, and the sample analyzer further includes a wheel portion; the two ends of the first flexible transmission member are wound around the shaft portion and the wheel portion, the limiting member is connected to the first flexible transmission member, and the limiting member drives the first flexible transmission member to move, so as to drive the shaft portion to rotate through the first flexible transmission member.

[0023] In some embodiments, the power mechanism includes a motor, a second reversing assembly, and a connecting structure. The motor has a power output shaft, and at least one of the sample holder and the second baffle is connected to the second reversing assembly via the connecting structure. The second reversing assembly is used to convert the rotation of the power output shaft into linear motion of the connecting structure along a first direction, thereby causing the connecting structure to drive the sample holder and the second baffle to move linearly along the first direction.

[0024] In some embodiments, the second reversing assembly includes an annular second flexible transmission member and a guide wheel; the two ends of the second flexible transmission member are wound around the guide wheel and the power output shaft, the connecting structure is connected to the second flexible transmission member, the power output shaft drives the second flexible transmission member to move during rotation, and the second flexible transmission member drives the connecting structure to move linearly along the first direction during movement.

[0025] In some embodiments, the second reversing assembly includes a rack and at least one gear; the rack is connected to the connecting structure, the at least one gear meshes with the rack, the power output shaft drives the at least one gear to rotate, and through the at least one gear drives the rack to move linearly along the first direction.

[0026] In some embodiments, the sample analyzer further includes a force application mechanism and a linkage mechanism; at least one of the first baffle, the second baffle, the sample holder, and the linkage mechanism is connected to the force application mechanism, which is used to drive the first baffle, the second baffle, and the sample holder to move under the action of an external force.

[0027] In some embodiments, the opening is used to form an injection channel for emergency samples; the sample holder is used to hold an emergency sample container; and / or, the opening is used to form an injection channel for regular samples, and the sample holder is used to hold a regular sample container.

[0028] The sample analyzer provided in this application embodiment can have its openings on the instrument faceplate covered by a baffle, regardless of whether the sample holder is inside or outside the housing assembly. This ensures good shielding of the sample analyzer, reduces the probability of aerosols generated by the sample inside the housing assembly leaking into the external environment of the housing assembly, and maintains the stability of the internal environment of the sample analyzer. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the structure of a sample analyzer provided in an embodiment of this application; Figure 2 for Figure 1 A schematic diagram of the structure of the Chinese embodiment from another perspective; Figure 3 for Figure 1 A schematic diagram of the structure of the embodiment from a side view; Figure 4 for Figure 1 A schematic diagram of the structure of the embodiment from a top-down perspective; Figure 5 for Figure 1 The schematic diagram of the shell structure is omitted in the Chinese embodiment; Figure 6 for Figure 1 A schematic diagram of the structure when the second baffle in the embodiment blocks the opening; Figure 7 for Figure 6 A schematic diagram of the structure of the Chinese embodiment from another perspective; Figure 8 for Figure 6 A schematic diagram of the structure of the embodiment from a side view; Figure 9 for Figure 6 A schematic diagram of the structure of the Chinese embodiment from a top-down perspective.

[0030] It should be noted that the terms "first" and "second" mentioned above are only used to distinguish between different options and do not represent the degree of superiority or inferiority of the options or their priority in the implementation process.

[0031] Explanation of reference numerals in the attached figures 100. Sample analyzer; 10. Surface shell; 10a. Opening; 20. Sample injection mechanism; 21. First baffle; 22. Second baffle; 23. Sample holder; 23a. Sample position; 24. Linkage mechanism; 241. First reversing assembly; 2411. First flexible transmission component; 242. Second reversing assembly; 2421. Motor; 24211. Power output shaft; 2422. Second flexible transmission component; 2423. Guide wheel; 243. Limiting component; 244. Elastic component; 245. Connecting structure; 25. Power mechanism; 26. Shaft; 30. Support platform; 40. Shaft frame; 50. Track; 50a. Protrusion; 60. Wheel. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of this application clearer, the following detailed description is provided in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application.

[0033] The specific technical features described in the specific embodiments can be combined in any suitable manner without contradiction. For example, different combinations of specific technical features can form different embodiments and technical solutions. To avoid unnecessary repetition, the various possible combinations of the specific technical features in this application will not be described separately.

[0034] In the following description, the terms "first..." and "second..." are used only to distinguish different objects and do not indicate that the objects have the sameness or relationship. It should be understood that the directional descriptions "above", "below", "outside", and "inside" refer to the orientation when in normal use, while "left" and "right" refer to the left and right directions as shown in the corresponding diagrams, which may or may not be the left and right directions of the normal use position.

[0035] It should be noted that the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes that element. "A plurality of" means two or more.

[0036] This application provides a sample analyzer 100. Please refer to... Figure 1 The sample analyzer 100 includes a housing assembly, a sample introduction mechanism 20, a reaction device, and a detection device (not shown in the figure). The housing assembly includes a faceplate with an opening. The sample introduction mechanism includes a sample holder and one or more baffles. The sample holder holds a sample container, which is used to hold the sample to be tested. The reaction device provides a reaction site for the mixture containing the sample and reagents in the reaction container and forms a reaction solution. The detection device detects the reaction solution to obtain the test result for the sample.

[0037] In some embodiments, the sample analyzer 100 can be used for PCR (polymerase chain reaction) detection to play a role in the rapid diagnosis of bacterial infectious diseases and other medical procedures in clinical practice. Of course, it can also be used in other types of IVD (in vitro diagnostic) devices, which are not limited here. The following description uses PCR detection as an example.

[0038] Please see Figure 2 The housing assembly includes a face shell 10, which has an opening 10a.

[0039] In some embodiments, the sample introduction mechanism 20 includes a sample holder 23 and a first baffle 21 and a second baffle 22.

[0040] In some embodiments, the sample holder 23 includes a sample position 23a for holding a sample container, which is used to hold a sample.

[0041] For example, the sample analyzer 100 also includes a scheduling mechanism that schedules the sample container on sample position 23a to the sample dispensing position (i.e., the aspiration position), the sample dispensing mechanism dispenses the sample from the sample container into the reaction container, the reagent dispensing mechanism dispenses the reagent from the reagent container into the reaction container, the reaction device provides a reaction site for the mixed solution containing the sample and reagent in the reaction container and forms a reaction solution, the reaction container containing the sample and reagent is scheduled to the detection position by the scheduling mechanism, and the detection device detects the reaction solution containing the sample and reagent in the reaction container to obtain the test result of the sample, thereby assisting in clinical diagnosis.

[0042] The sample holder 23 can enter the interior of the housing assembly from the outside of the housing assembly through the opening 10a, or extend from the interior of the housing assembly to the outside of the housing assembly through the opening 10a.

[0043] For example, the injection mechanism 20 includes an injection state and a non-injection state.

[0044] Please see Figure 1 and Figure 2 In the non-sample injection state, the sample holder 23 is located inside the housing assembly, and the baffle blocks the opening 10a. For example, in an embodiment where one or more baffles include a first baffle 21 and a second baffle 22, the first baffle 21 blocks the opening 10a. In this case, the internal space of the housing assembly cannot exchange airflow with the external environment through the opening 10a. The second baffle 22 avoids the opening 10a, meaning it is far from the opening 10a and does not interfere with the first baffle 21 at the opening 10a. That is, in the non-sample injection state, the internal and external spaces of the sample analyzer 100 remain isolated. Wherein, for example... Figure 2 As shown, the sample holder 23 is located inside the housing assembly at the sample aspiration position to hold the sample container to be dispatched to the aspiration position for aspiration. At this time, the first baffle 21 blocks the opening 10a.

[0045] Please see Figure 6 and Figure 7In the sample introduction state, the sample position 23a extends to the outside of the housing assembly through the opening 10a, that is, the sample position 23a is exposed to the external environment for receiving the sample, and the baffle blocks the opening 10a. For example, in an embodiment where one or more baffles include a first baffle 21 and a second baffle 22, the second baffle 22 blocks the opening 10a. At this time, the internal space of the housing assembly cannot exchange airflow with the external environment through the opening 10a. In this case, the first baffle 21 avoids the opening 10a, that is, the first baffle 21 moves away from the opening 10a and does not interfere with the second baffle 22 at the opening 10a. Wherein, as... Figure 7 As shown, the sample holder 23 is located at the loading position outside the housing assembly to receive the sample container loaded onto the sample holder 23. That is, when the sample introduction mechanism 20 is in the sample introduction state, the internal space of the sample analyzer 100 is isolated from the sample position 23a exposed to the external environment. During the process of loading the sample into the sample position 23a, the airflow in the external environment is not likely to enter the interior of the sample analyzer 100 through the opening 10a, reducing the impact on the internal environmental conditions of the instrument. At the same time, the gases that may contain contaminants inside the sample analyzer 100 are not likely to escape into the external environment through the opening 10a, reducing the exposure risk to the operator of the sample analyzer.

[0046] It should be noted that the non-sample injection state refers to the position of the sample holder. The state in which the sample holder is inside the outer casing can be called the non-sample injection state. It can be the state in which the sample analyzer 100 is in analysis operation, or it can be the standby state, the power-off state, etc., without limitation.

[0047] In some embodiments, the sample introduction mechanism includes an unloading state. In the unloading state, the sample holder 23 carries the sample container to be retrieved (e.g., a sample container that has completed sample testing) and extends from the inside of the housing assembly to the outside of the housing assembly through the opening 10a to transport the sample container to be retrieved from the inside of the housing assembly to the retrieval position outside the housing assembly. When the sample holder 23 is located at the retrieval position outside the housing assembly, the one or more baffles block the opening 10a. For example, in an embodiment where the one or more baffles include a first baffle 21 and a second baffle 22, the second baffle 22 blocks the opening 10a. At this time, the internal space of the housing assembly cannot exchange airflow with the external environment through the opening 10a. In this case, the first baffle 21 avoids the opening 10a, that is, the first baffle 21 moves away from the opening 10a and does not interfere with the second baffle 22 at the opening 10a. When the sample introduction mechanism 20 is in the unloaded state, the internal space of the sample analyzer 100 is isolated from the sample position 23a exposed to the external environment. Airflow in the external environment is not likely to enter the interior of the sample analyzer 100 through the opening 10a, reducing the impact on the internal environmental conditions of the instrument. At the same time, gases that may contain pollutants inside the sample analyzer 100 are not likely to escape to the external environment through the opening 10a, reducing the exposure risk to the operators of the sample analyzer.

[0048] It should be noted that, regardless of whether it is in the unloading or injection state, the movement of the sample holder 23 is from inside the outer shell assembly to outside the outer shell assembly through the opening 10a. The difference is that in the injection state, the sample holder 23 extends outside the outer shell assembly to receive the sample to be tested, while in the unloading state, the sample holder 23 extends outside the outer shell assembly carrying the sample container to be retrieved, so that the user or a robotic arm can remove the sample container to be retrieved.

[0049] Of course, some sample analyzers do not process the recovered sample containers from the opening 10a. In this case, the sample analyzer does not have the unloading state described above.

[0050] In this embodiment of the application, the purpose of the baffle shielding (or closing) the opening 10a is to prevent or minimize the airflow exchange between the inside and outside of the housing assembly. When the baffle shields (or closes) the opening 10a, the baffle and the structure around the opening 10a are in sealed contact as much as possible, but a small amount of fit gap is also allowed at the fit, for example, the fit gap is no more than 2mm.

[0051] Some sample analyzers 100 are sensitive to environmental conditions such as temperature, humidity, and airflow when detecting samples. In the embodiment of the sample analyzer 100 provided in this application, including the first baffle 21 and the second baffle 22, both the first baffle 21 and the second baffle 22 can shield the opening 10a, ensuring good shielding of the sample analyzer 100 in both non-sample-injection and sample-injection states. Furthermore, when the sample-injection mechanism 20 switches between non-sample-injection and sample-injection states, and the first baffle 21 moves away to allow the sample holder 23 to extend through the opening 10a, the second baffle 22 can be adjusted to shield the opening 10a as quickly as possible after the sample holder 23a extends, significantly shortening the opening time of the opening 10a and thus maintaining internal and external isolation of the sample analyzer 100 throughout the entire sample-injection process.

[0052] Maintaining good shielding of the sample analyzer 100 and shortening the opening time of the opening 10a helps maintain a relatively stable pressure difference between the inside of the housing assembly and the external environment, which in turn helps maintain a stable sample detection environment, thereby improving the accuracy and repeatability of the sample detection results. Furthermore, it minimizes the escape of contaminating gases from the sample analyzer 100 to the external environment when the opening 10a is open, and also prevents contaminating gases from the external environment from easily entering the sample analyzer 100 and adversely affecting the stability and accuracy of sample detection.

[0053] For example, in one embodiment, opening 10a is the sample inlet channel for emergency samples, sample position 23a is used to hold an emergency sample container, the emergency sample container is used to hold emergency samples, and the sample analyzer 100 is used in emergency scenarios. In the emergency room, time is more precious, and the requirements for the accuracy and efficiency of sample testing results are higher. The sample analyzer 100 provided in this embodiment can be applied to medical diagnosis, and has good shielding, high reliability of experimental results, and is not easily contaminated. When deployed in clinical use, it can significantly reduce the exposure risk of medical workers while ensuring the accuracy of sample testing results.

[0054] In some embodiments, opening 10a serves as a sample inlet channel for conventional samples, and the sample holder is used to hold conventional sample containers.

[0055] In some embodiments, the same sample analyzer can be used only for testing emergency samples and not for testing routine samples. Alternatively, it can be used only for testing routine samples and not for testing emergency samples. It can also be used for testing both emergency and routine samples. In this embodiment, there are at least two openings 10a, one serving as the emergency sample inlet channel and the other as the routine sample inlet channel. In this case, the sample holders for emergency samples and routine samples can share the same sample compartment inside the outer shell assembly. This allows for the sharing of scheduling mechanisms, opening and closing mechanisms, etc., for emergency and routine sample testing. Of course, the sample holders for emergency samples and routine samples can also have their own separate sample compartments.

[0056] In this embodiment of the application, emergency samples are given a higher priority than regular samples.

[0057] Emergency samples are suitable for life-threatening or urgent medical situations, such as acute myocardial infarction, severe trauma, shock, acute poisoning, and febrile coma. Emergency sample containers are typically labeled differently from those for routine samples.

[0058] In some embodiments, the housing assembly contains a sample compartment, in which the sample introduction mechanism is housed when not in the sample introduction state. The sample compartment refers to the space within the housing assembly where the sample container is located. This sample compartment is a negative pressure environment, meaning the air pressure within the sample compartment is lower than the air pressure of the external environment (atmosphere). Thus, even if a small amount of sample aerosol is generated within the sample compartment, the aerosol is less likely to diffuse into the external environment of the sample analyzer under negative pressure, reducing the chance of aerosol exposure for medical or testing personnel. This is especially important when the sample analyzer is used for molecular diagnostics, as samples may contain contaminants such as viruses and bacteria. Contact with these contaminants poses a risk of infection; in such cases, the negative pressure environment significantly reduces the likelihood of viruses and bacteria spreading to the external environment and other areas outside the sample compartment.

[0059] For example, a ventilation system can be used to continuously draw air from the sample chamber, maintaining a negative pressure. Of course, the air drawn by the ventilation system also needs to be sterilized using a filtration or sterilization device.

[0060] In some embodiments, the sample analyzer includes a sample dispensing unit and a pipetting unit disposed on the sample dispensing unit.

[0061] The pipetting component can be, for example, a sample needle or a pipette tip (or TIP tip). The sample dispensing component moves the pipetting component between different operating positions to aspirate or dispense samples. The pipetting component aspirates samples based on negative pressure and dispenses samples when positive or negative pressure decreases. The sample analyzer also includes a pressure detection mechanism and a processor. The pressure detection mechanism detects the pressure within the pipetting component, and the processor receives the pressure signal output by the pressure detection mechanism and determines whether the pipetting component is leaking based on the pressure signal.

[0062] For example, when the pipette picks up a sample, if the negative pressure inside the pipette is not higher than a preset pressure, the sample will not drip from the pipette. However, if the pressure inside the pipette reaches or exceeds the preset pressure, the negative pressure is insufficient, and the sample will likely drip from the pipette. Therefore, the processor receives a pressure signal and compares the pressure signal value with the preset pressure. If the pressure signal value is not less than the preset pressure, it is determined that dripping exists. If the pressure signal value is less than the preset pressure, it is determined that no dripping exists.

[0063] When the processor detects the presence of liquid, it can output a warning message to alert medical staff or testing personnel.

[0064] In some embodiments, the sample analyzer further includes a dropper tray located below and moving with the pipette component to collect sample droplets from the pipette component. It should be noted that "the dropper tray moves with the pipette component" means that when the pipette component moves to a certain position, the dropper tray also moves directly below that position. The dropper tray can be driven by the sample dispensing component or by other mechanisms, and this is not limited to these methods.

[0065] In this embodiment, at least after the pipette picks up the sample, the dropper is always located below the pipette along the path of the pipette transferring the sample. Even if a small amount of sample drips from the pipette, it can be caught by the dropper, preventing the sample from dripping onto the bottom wall of the sample chamber or other structures, and reducing the chance of the sample contaminating surrounding components.

[0066] It should be noted that the sample analyzer also includes a sterilization mechanism, which sterilizes the droplet receiving tray. The sterilization method is not limited, such as irradiation with radiation light or cleaning with cleaning solution.

[0067] In some embodiments, the sample analyzer includes a probe for mixing the reaction solution containing the sample in the container. During mixing, the tip of the probe remains submerged in the reaction solution; that is, the tip of the probe does not leave the liquid surface throughout the entire process from the start to the end of stirring. This reduces the likelihood of the probe creating bubbles in the reaction solution. It is understood that if bubbles are present in the reaction solution, their bursting would release significant energy, causing sample to splash and potentially contaminate surrounding structures.

[0068] In some embodiments, the sample analyzer includes a scheduling mechanism, a clamping mechanism, and a cap-opening / closing mechanism. The scheduling mechanism is used to schedule sample containers on the sample holder to the cap-opening position. In some embodiments, the scheduling mechanism is also used to schedule sample containers that have completed sample dispensing and are located at the cap-opening position back to the sample position on the sample holder.

[0069] For example, a sample container, such as a sample tube, includes a tube body and a cap. The cap covers the opening of the tube body. After the cap is removed from the opening of the tube body, it can be replaced to close the opening again. For example, the upper end of the tube body and the cap can be threaded together, so that the cap needs to be rotated to open or close it. Alternatively, the upper end of the tube body and the cap can be tightly fitted based on friction. It should be noted that after the sample is placed in the tube body, the cap closes the opening of the tube body to prevent aerosols formed from the sample from spilling out. When it is time to aspirate the sample, the sample tube must first be moved to the open position, the cap opened at the open position, the sample aspirated, the cap closed at the open position, and then the sample tube returned to the sample position in the sample holder.

[0070] The clamping mechanism is used to clamp or release the tube body of the sample container located in the open position. In other words, when the sample container is moved to the open position, the clamping mechanism can clamp the tube body and position it.

[0071] The cap-opening and closing mechanism is used to hold the cap of the sample tube in the open position to open or close the sample tube. Specifically, when the sample container is in the open position, the clamping mechanism holds the tube body, and the cap-opening and closing mechanism holds the cap. The cap-opening and closing mechanism drives the cap upward. For example, when the cap and the upper end of the tube body are in a frictional tight fit, the cap-opening and closing mechanism drives the cap upward in a linear motion; when the cap and the upper end of the tube body are in a threaded fit, the cap-opening and closing mechanism drives the cap upward in a spiral motion. This separates the cap from the opening of the tube body, thus opening the sample container. After opening, when closing is required, the cap-opening and closing mechanism aligns the cap with the opening of the tube body, drives the cap downward, and places the cap back on the upper end of the tube body, thus closing the sample container.

[0072] It should be noted that the sample may contain contaminants such as viruses. Therefore, after opening the tube, the cap should be replaced on the tube body to prevent contaminants from spreading into the environment.

[0073] The sample analyzer also includes a suction port, which faces the opening of the tube body located in the open position. In this way, after the cap is opened, the sample is prone to forming aerosols and spreading out. By promptly removing the aerosols through the suction port, the diffusion area of ​​the aerosols can be effectively controlled, and the scope of aerosol contamination can be reduced.

[0074] In addition to setting suction ports near the sample location, suction ports can also be set at other suitable locations in the sample chamber to coordinate the control of the negative pressure environment of the sample chamber through multiple suction ports.

[0075] In some embodiments, the sample holder and one or more baffles are electrically linked by electrical control, or one or more baffles are mechanically linked by connection to the sample holder.

[0076] Electrical linkage refers to the electrical control logic connection between the two. For example, one power source drives the sample holder to move, and another power source drives one of the baffles to move. Controlling the output of power from one power source also controls the output of power from the other power source. In this way, even if the sample holder and the baffle are not connected, they can still be linked in their actions.

[0077] Mechanical linkage refers to the physical connection between two things, so that when one moves, it will cause the other to move as well.

[0078] In this embodiment, the linkage between the sample holder and one or more baffles facilitates coordinated control and movement of the sample holder and one or more baffles.

[0079] In some embodiments, please refer to Figure 3 and Figure 8 The second baffle 22 is connected to the sample holder 23 and moves synchronously. Synchronous movement, as mentioned in this specification, refers to the simultaneous movement of multiple structures. Exemplarily, the sample holder 23 is connected to the surface of the second baffle 22 facing the opening 10a. It should be noted that the sample holder 23 itself needs to move to perform the sample introduction function, and the connection and synchronous movement of the second baffle 22 with the sample holder 23 allows the second baffle 22 to move by means of the movement of the sample holder 23, eliminating the need for a separate drive device for the second baffle 22 and saving internal space in the instrument.

[0080] Please see Figure 7 and Figure 8During the process of the sample injection mechanism 20 moving from the inside of the housing assembly (which can be understood as the non-sample injection state) to the outside of the housing assembly (e.g., moving to the sample injection state), the second baffle 22 and the sample holder 23 move synchronously from the inside of the housing assembly to the opening 10a. The first baffle 21 moves to avoid the opening 10a, so that the sample position 23a extends to the outside of the housing assembly through the opening 10a.

[0081] Please see Figure 2 and Figure 3 During the process of the sample injection mechanism 20 moving from the outside of the housing assembly (e.g., the sample injection state, or the unloading state) to the non-sample injection state, the second baffle 22 and the sample holder 23 move synchronously from the opening 10a to the inside of the housing assembly so that the sample position 23a returns to the inside of the housing assembly; during this process, the first baffle 21 moves to block the opening 10a.

[0082] In this embodiment, when the sample holder 23 moves, the second baffle 22 moves; when the sample holder 23 is stationary, the second baffle 22 is stationary. In the sample introduction state, when the sample position 23a moves towards the opening 10a to extend outside the housing assembly and reaches its position, the second baffle 22 also stops moving and blocks the opening 10a. Therefore, the opening time of the opening 10a is significantly shortened during the process of the sample analyzer 100 opening the opening 10a to receive the sample.

[0083] Furthermore, while the second baffle 22 is moving, the first baffle 21 can also move; while the first baffle 21 is moving, the second baffle 22 can also move, so that the sample analyzer 100 can coordinate the scheduling of the first baffle 21 and the second baffle 22 for a period of time, and respond quickly to the action of blocking the opening 10a.

[0084] For example, in some embodiments, the first baffle 21 and the second baffle 22 are each controlled by a separate drive device, and multiple drive devices drive the first baffle 21 and the second baffle 22 to move respectively. In this embodiment, the first baffle 21 and the second baffle 22 can be electrically linked, or they can be not electrically linked. In other embodiments, the first baffle 21 and / or the second baffle 22 can also be manually operated, that is, no drive device is configured, and it relies on manual operation.

[0085] For example, in some other embodiments, the sample introduction mechanism 20 further includes a linkage mechanism 24. As used in this specification, linkage refers to a mechanism between multiple structures where movement of one structure can transmit power to another structure via the linkage mechanism 24 to drive the other structure to move; the direction of power transmission depends on the form of the linkage mechanism 24.

[0086] For example, the linkage mechanism 24 is used to link the first baffle 21 and the second baffle 22 so that, as the second baffle 22 moves toward the opening 10a, the first baffle 21 moves to avoid the opening 10a. That is, as the opening 10a gradually opens, the second baffle 22 moves toward the opening 10a so that, after the opening 10a has finished opening (at which point the sample position 23a extends outside the housing assembly), the second baffle 22 can quickly block the opening 10a. Conversely, as the second baffle 22 moves toward the interior of the housing assembly, the first baffle 21 moves to block the opening 10a. That is, as the opening 10a gradually opens, the first baffle 21 moves toward the opening 10a so that, after the opening 10a has finished opening (at which point the sample position 23a retracts into the housing assembly), the first baffle 21 can quickly block the opening 10a.

[0087] Therefore, not only can the power of the second baffle 22 be reused and fewer driving devices be set, but the scheduling of the first baffle 21 and the second baffle 22 by the sample analyzer 100 can also be coordinated for a period of time. During the process of the sample analyzer 100 opening the opening 10a to receive the sample, the opening time of the opening 10a is significantly shortened.

[0088] For example, in one embodiment, during the movement of the second baffle 22 toward the opening 10a, the first baffle 21 is moved by the linkage mechanism 24 to avoid the opening 10a, and during the movement of the second baffle 22 toward the interior of the housing assembly, the first baffle 21 is moved by the linkage mechanism 24 to cover the opening 10a.

[0089] In some embodiments, please refer to Figure 1 , Figure 2 as well as Figure 6 , Figure 7 The inner surface of the shell 10 has a sealing mating surface (not shown in the figure). The sealing mating surface surrounds the opening 10a and is used to seal with the first baffle 21 or the second baffle 22. That is, when the first baffle 21 covers the opening 10a, the sealing mating surface seals with the first baffle 21; when the second baffle 22 covers the opening 10a, the sealing mating surface seals with the second baffle 22, thereby achieving the covering of the opening 10a and improving the tightness of the covering of the opening.

[0090] For example, the first baffle 21 rotates relative to the face shell 10 to shield and avoid the opening 10a; and the rotation center line of the first baffle 21 (e.g. Figure 6 (As shown by the dotted line in the image) is parallel to the sealing mating surface. The first baffle 21 can change its angle relative to the shell 10 by rotating, thereby achieving the shielding and avoidance of the opening 10a.

[0091] It is understandable that when the injection mechanism 20 is in a non-injection state, the first baffle 21 engages with the sealing mating surface, such as... Figure 4 As shown, the first baffle 21 is at the first angle position A1, and the angle of the first baffle 21 at this time is recorded as 0°. The sample injection mechanism 20 is in the sample injection state, as shown. Figure 9 As shown, the first baffle 21 is in the second angle position A2. The first baffle 21 rotates to the maximum angle between itself and the sealing mating surface. This maximum angle can be understood as the maximum rotation stroke of the first baffle 21.

[0092] The first baffle 21 rotates, making its movement easy to control. For example, its angle can be adjusted using a stepper motor or indexing device, or it can be adjusted by the second baffle 22 via a linkage mechanism 24, which helps improve the reliability of the sample analyzer. Furthermore, when the first baffle 21 rotates to cover the opening 10a, it has a tangential displacement relative to the opening 10a along its rotation trajectory, allowing the first baffle 21 to better contact the sealing mating surface and improving sealing performance.

[0093] The maximum rotation stroke Max of the first baffle 21 is not limited, as long as it can open or close the opening 10a and does not interfere with the sample holder 23 or the second baffle 22.

[0094] For example, in some embodiments, the rotational stroke of the first baffle 21 is greater than 0° and does not exceed 90°. That is, the first baffle 21 can rotate between 0° (excluding the baffle itself) and 90°. Here, 90° can be understood as the maximum rotational stroke of the first baffle 21.

[0095] In some other embodiments, the maximum rotational stroke Max of the first baffle 21 is 80°~100°. For ease of description, as... Figure 4 and Figure 9 As shown, the angle between the first baffle 21 and the sealing mating surface is denoted as ε, i.e., 0°≤ε≤Max, where 80°≤Max≤100°, and the value of Max includes 80°, 90°, 100°, and any value within the range. In this embodiment, the rotation stroke of the first baffle 21 can be 0° (excluding itself) to 80°, 0° (excluding itself) to 90°, or 0° (excluding itself) to 100°, etc.

[0096] For example, the sample injection mechanism 20 includes a driving mechanism that drives the first baffle 21 to translate. It should be noted that translation means that during the motion of an object, the straight line connecting any two points on the object remains parallel throughout the entire motion. This motion can be linear motion or curvilinear motion, but all points on the object have the same velocity and acceleration at any given time, and the displacements of all particles in the object are parallel within any given time period.

[0097] The translational displacement of the first baffle 21 includes a displacement component in the first direction D1 and a displacement component in the second direction D2. The first direction D1 is perpendicular to the sealing mating surface, and the second direction D2 is parallel to the sealing mating surface. It should be noted that the translational motion of the first baffle 21 can be a combined motion along the first direction D1 and the second direction D2, or a simple combination of motions that first translate along one direction and then along the other.

[0098] The displacement component of the first baffle 21 along the second direction D2 allows it to approach or avoid the opening 10a, and the displacement component of the first baffle 21 along the first direction D1 allows it to fit tightly against the sealing mating surface to cover the opening 10a. The first baffle 21 adopts a translational motion, which does not require occupying the internal space of the housing assembly.

[0099] In some embodiments, please refer to Figure 3 and Figure 8 The sample holder 23 and the second baffle 22 move linearly along the first direction D1. It can be understood that when the sample injection mechanism 20 is not in the sample injection state, the second baffle 22 is away from and avoids the opening 10a, and the second baffle 22 has a first position B1 in the first direction D1; when the sample injection mechanism 20 is in the sample injection state, the second baffle 22 engages with the sealing mating surface, and the second baffle 22 has a second position B2 in the first direction D1.

[0100] The sample holder 23 and the second baffle 22 adopt a linear motion, which on the one hand facilitates the sample position 23a to extend out of the outer shell assembly through the opening 10a and facilitates the cooperation between the second baffle 22 and the sealing mating surface. On the other hand, the motion is relatively stable, which makes it less likely for the sample container carried by the sample position 23a to shake violently as it moves with the sample holder 23, so as to avoid changes in the properties of the sample that may occur due to shaking.

[0101] For example, in one embodiment, the sample holder 23 is disposed on the side surface of the second baffle 22 along the first direction D1 near the opening 10a, and the sample holder 23 is connected to the second baffle 22 and moves synchronously.

[0102] In some embodiments, please refer to Figure 9The sample introduction mechanism 20 also includes a power mechanism 25, which drives the sample holder 23 and the second baffle 22 to move linearly along the first direction D1. That is, the power of the second baffle 22 comes from the power output of the power mechanism 25. The power mechanism 25 enables the sample introduction function of the sample analyzer 100 to be automated, thereby reducing the workload of medical workers in clinical operations.

[0103] The power mechanism 25 can directly drive the second baffle 22 to move, and the sample holder 23 can move with the second baffle 22, or it can directly drive the sample holder 23 to move, and the second baffle 22 can move with the sample holder 23. The form of the power mechanism 25 can be a motor 2421 and its transmission mechanism, or a hydraulic pump and its transmission mechanism, etc., which is not limited here.

[0104] In some embodiments, the sample analyzer 100 further includes a force-applying mechanism. At least one of the first baffle 21, the second baffle 22, the sample holder 23, and the linkage mechanism 24 is connected to the force-applying mechanism, which is used to drive the first baffle 21, the second baffle 22, and the sample holder 23 to move under the action of an external force. Thus, medical workers can manually control the movement of the first baffle 21, the second baffle 22, and the sample holder 23 through the force-applying mechanism, which has the advantages of low cost and high reliability.

[0105] In some embodiments, the sample holder 23 and the second baffle 22 move linearly along the first direction D1, and the first baffle 21 and the second baffle 22 are linked by a linkage mechanism 24. That is, the displacement of the second baffle 22 along the first direction D1 can cause the first baffle 21 to move.

[0106] Please see Figure 1 and Figure 6 The sample injection mechanism 20 also includes a shaft 26 connected to the first baffle 21. Exemplarily, the rotation center line of the first baffle 21 passes through the shaft 26. The linkage mechanism 24 includes a limiting member 243 and a first reversing assembly 241. The movement of the second baffle 22 and the sample holder 23 drives the limiting member 243 to move linearly along the first direction D1. The first reversing assembly 241 connects the limiting member 243 and the shaft 26, converting the linear movement of the limiting member 243 along the first direction D1 into rotation of the shaft 26, which in turn drives the first baffle 21 to rotate. Thus, the displacement of the second baffle 22 along the first direction D1 is converted into rotation of the first baffle 21 about its rotation center line.

[0107] For example, when the second baffle 22 moves toward the opening 10a, it drives the limiting member 243 to move, thereby driving the first baffle 21 to rotate and avoid the opening 10a. When the second baffle 22 blocks the opening 10a and stops moving, the first baffle 21 has rotated to the second angle position A2 and stopped rotating.

[0108] For example, when the second baffle 22 moves away from the opening 10a, it drives the limiting member 243 to move, thereby driving the first baffle 21 to rotate and thus cover the opening 10a. When the second baffle 22 moves to the first position B1 and stops moving, the first baffle 21 has covered the opening 10a and stopped rotating.

[0109] In some embodiments, please refer to Figure 1 , Figure 5 and Figure 6 The first reversing assembly 241 includes an annular first flexible transmission member 2411, and the sample analyzer 100 also includes a wheel portion 60. The two ends of the first flexible transmission member 2411 are wound around the shaft portion 26 and the wheel portion 60. The limiting member 243 is connected to the first flexible transmission member 2411, and the limiting member 243 drives the first flexible transmission member 2411 to move, so as to drive the shaft portion 26 to rotate through the first flexible transmission member 2411.

[0110] For example, in one embodiment, the wheel portion 60, the shaft portion 26, and the first flexible transmission member 2411 constitute a belt drive mechanism, wherein the first flexible transmission member 2411 may be a flat belt or a V-belt.

[0111] For example, in one embodiment, the wheel portion 60, the shaft portion 26, and the first flexible transmission member 2411 constitute a chain drive mechanism, wherein the first flexible transmission member 2411 may be a chain.

[0112] For example, the first reversing component 241 may also take the form of, but is not limited to: a first type, where the first reversing component 241 is a guide rod slider mechanism, where the limiting member 243 drives the slider to move, thereby causing the guide rod to rotate, and the guide rod drives the shaft 26 to rotate; a second type, where the first reversing component 241 is a gear and rack transmission mechanism, where the limiting member 243 drives the rack to move, thereby causing the gear to rotate, and the gear drives the shaft 26 to rotate.

[0113] In some embodiments, please refer to Figure 2 , Figure 3 as well as Figure 7 , Figure 8 The sample analyzer 100 also includes a support platform 30 and a shaft bracket 40. A first baffle 21, a second baffle 22, and a sample holder 23 are all disposed on the top side of the support platform 30. The shaft bracket 40 is connected to the support platform 30 and has at least two shaft holes arranged coaxially in the height direction of the sample analyzer 100. A shaft portion 26 rotatably passes through the at least two shaft holes. Thus, the first baffle 21 is rotatably disposed on the support platform 30, and the rotation center line of the first baffle 21 extends along the height direction of the sample analyzer 100.

[0114] In some embodiments, please refer to Figure 1 and Figure 4The sample analyzer 100 also includes a track 50 that extends linearly along a first direction D1 on the top surface of the support platform 30. Exemplarily, the track 50 has a protrusion 50a that protrudes from the top surface of the support platform 30, such as... Figure 2 As shown.

[0115] For example, the track 50 is used to guide the linear movement of the sample holder 23 along the first direction D1, and the bottom side of the sample holder 23 has a recess that mates with the protrusion 50a.

[0116] For example, the track 50 is used to guide the linear movement of the second baffle 22 along the first direction D1, and the bottom side of the second baffle 22 has a recess that mates with the protrusion 50a.

[0117] For example, the track 50 is used to guide the linear movement of the sample holder 23 and the second baffle 22 along the first direction D1.

[0118] In some embodiments, please refer to Figure 1 and Figure 4 The linkage mechanism 24 also includes an elastic element 244.

[0119] The movement of the second baffle 22 and the sample holder 23 in the first direction D1 includes a first stroke segment and a second stroke segment, wherein the first stroke segment is located on the side closer to the interior of the housing assembly, and the second stroke segment is located on the side closer to the opening 10a.

[0120] In the first stroke segment, the elastic element 244 applies a spring force to the limiting element 243 in the direction close to the opening 10a. At least one of the sample seat 23 and the second baffle 22 abuts against the limiting element 243 along the first direction D1 under the action of the spring force. When the sample seat 23 and the second baffle 22 move, they drive the limiting element 243 to move, so that the second baffle 22, the sample seat 23 and the limiting element 243 are linked together. Figure 2 and Figure 3 .

[0121] For example, when the second baffle 22 and the sample holder 23 move away from the opening 10a, during the first stroke segment, the limiting member 243 moves and the elastic member 244 deforms, so that under the action of the elastic force, the limiting member 243 remains against at least one of the second baffle 22 and the sample holder 23, and moves with the movement of the second baffle 22 and the sample holder 23. When the second baffle 22 and the sample holder 23 move closer to the opening 10a, during the first stroke segment, the elastic member 244 recovers its deformation, so that under the action of the elastic force, the limiting member 243 is driven to follow the movement of the second baffle 22 and the sample holder 23.

[0122] For example, the endpoint of the first stroke segment away from the opening 10a is the first position B1 of the second baffle 22.

[0123] In the second stroke phase, the elastic element 244 is in its natural state, and both the sample holder 23 and the second baffle 22 are separated from the limiting element 243, so that while the sample holder 23 and the second baffle 22 are moving, the linkage mechanism 24 remains stationary. Figure 7 and Figure 8 .

[0124] For example, when the second baffle 22 and sample holder 23 move away from the opening 10a, during the second stroke segment, the limiting member 243 remains stationary, and the displacement of the second baffle 22 is not transmitted to the first baffle 21 through the linkage mechanism 24, thus the first baffle 21 remains stationary. When the second baffle 22 and sample holder 23 move closer to the opening 10a, during the second stroke segment, the limiting member 243 remains stationary, and the displacement of the second baffle 22 is not transmitted to the first baffle 21 through the linkage mechanism 24, thus the first baffle 21 remains stationary.

[0125] For example, the endpoint of the second stroke segment near the opening 10a is the second position B2 of the second baffle 22.

[0126] It is understandable that the time corresponding to the movement of the second baffle 22 and the sample holder 23 in the second stroke segment is the time during which the first baffle 21 moves in conjunction with the second baffle 22. During this time, the sample analyzer 100 coordinates the scheduling of the first baffle 21 and the second baffle 22. The time corresponding to the movement of the second baffle 22 and the sample holder 23 in the first stroke segment is the time during which the first baffle 21 remains stationary. During this time, the first baffle 21 avoids the opening 10a and remains stationary, making room for the movement of the second baffle 22 and the sample holder 23, and reducing the probability of structural interference with them.

[0127] It is understandable that the lengths of the first stroke segment and the second stroke segment can be adjusted by adjusting the position of the limiting member 243 on the support platform 30 or changing its length in its natural state, thereby adjusting the movement relationship between the first baffle 21 and the second baffle 22, reducing the probability of structural interference between the two, and ensuring that the opening 10a can be covered.

[0128] Furthermore, during the first stroke segment, when the second baffle 22 and the sample holder 23 move toward the opening 10a, the first baffle 21 needs to avoid the opening 10a to make room for the second baffle 22 and the sample holder 23. During this process, the elastic element 244 recovers its deformation, causing the limiting element 243 to drive the first baffle 21 to rotate. The second baffle 22 and the limiting element 243 are non-rigidly connected, which can reduce impact and compensate for the movement error of the limiting element 243 to a certain extent, reducing the precision requirements for motion control, achieving smooth and effective transmission, and helping to improve the reliability of the entire sample analyzer 100.

[0129] In addition, during the second stroke segment, since the limiting member 243 is stationary, the first baffle 21 also remains stationary when it is in the second angle position, reducing the space required for it to continue moving in the direction of increasing the angle with the sealing mating surface.

[0130] The form of the elastic element 244 is not limited; it can be a tension spring, a compression spring, or an elastic rope, etc.

[0131] In some embodiments, please refer to Figure 5 and Figure 9 The power mechanism 25 includes a motor 2421, a second commutation assembly 2421, and a connecting structure 245. The motor 2421 has a power output shaft 24211. At least one of the sample seat 23 and the second baffle 22 is connected to the second commutation assembly 2421 through the connecting structure 245. That is, the connecting structure 245 can be connected to the sample seat 23, the second baffle 22, or both.

[0132] The second reversing assembly 2421 converts the rotation of the power output shaft 24211 into linear motion of the connecting structure 245 along the first direction D1, thereby causing the connecting structure 245 to drive the sample holder 23 and the second baffle 22 to move linearly along the first direction D1. In this embodiment, the position and direction of movement of the second baffle 22 and the sample holder 23 can be controlled by controlling the start, stop, and forward / reverse rotation of the motor 2421. The control method is simple, stable, and reliable.

[0133] For example, in one embodiment, please refer to Figure 5 The second reversing assembly 2421 includes an annular second flexible transmission member 2422 and a guide wheel 2423. The two ends of the second flexible transmission member 2422 are wound around the guide wheel 2423 and the power output shaft 24211. A connecting structure 245 is connected to the second flexible transmission member 2422. During rotation, the power output shaft 24211 drives the second flexible transmission member 2422 to move, and during this movement, the second flexible transmission member 2422 drives the connecting structure 245 to move linearly along the first direction D1.

[0134] That is, the power output shaft 24211, the guide wheel 2423 and the second flexible transmission component 2422 constitute a belt drive mechanism or a chain drive mechanism, thereby converting the rotational displacement of the power output shaft 24211 into the linear displacement of the connecting structure 245, so that the connecting structure 245 drives the second baffle 22 and the sample seat 23 to move with a sufficiently long linear motion stroke.

[0135] The second flexible transmission component 2422 can be in the form of a belt or chain, etc.

[0136] In one embodiment, for example, the second reversing assembly 2421 includes a rack and at least one gear. The rack is connected to the connecting structure 245, and the at least one gear meshes with the rack. The power output shaft 24211 drives the at least one gear to rotate, and through the at least one gear, drives the rack to move linearly along the first direction D1, thereby driving the connecting structure 245 to move the second baffle 22 and the sample holder 23 linearly. The gear and rack meshing transmission method has high efficiency and accurate transmission position.

[0137] In the description of this application, the terms "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the embodiments of this application. In this application, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Furthermore, without contradiction, those skilled in the art can combine different embodiments or examples described in this application, as well as features of different embodiments or examples.

[0138] The above description is merely a preferred embodiment of this application and is not intended to limit the application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the scope of protection of this application.

Claims

1. A sample analyzer, characterized in that, include: A housing assembly, the housing assembly including a face shell having an opening; The sample injection mechanism includes a sample holder and one or more baffles; the sample holder is used to support a sample container, and the sample container is used to hold the sample to be tested. A reaction apparatus is used to provide a reaction site for a mixed solution containing the sample to be tested and reagents in a reaction vessel and to form a reaction solution; A detection device is used to detect the reaction solution to obtain the detection results of the sample to be tested; Wherein, when the sample holder enters the interior of the housing assembly from the outside of the housing assembly through the opening, or extends from the interior of the housing assembly to the outside of the housing assembly through the opening, the one or more baffles open the opening; When the sample holder is located in the sample-to-absorption position inside the housing assembly or in the loading position outside the housing assembly, the one or more baffles cover the opening; the sample holder is located in the sample-to-absorption position to place a sample container to be dispatched to the aspiration position for aspiration, and the sample holder is located in the loading position to receive a sample container loaded onto the sample holder.

2. The sample analyzer according to claim 1, characterized in that, The sample injection mechanism includes an unloading state; In the unloaded state, the sample holder carries the sample container to be recycled and extends from the inside of the outer shell assembly to the outside of the outer shell assembly through the opening, so as to transport the sample container to be recycled from the inside of the outer shell assembly to the recycling position outside the outer shell assembly; When the sample holder is located in the recycling position outside the housing assembly, the one or more baffles cover the opening.

3. The sample analyzer according to claim 1, characterized in that, The outer casing assembly has a sample chamber inside, and the air pressure in the sample chamber is lower than the air pressure outside the outer casing assembly.

4. The sample analyzer according to claim 1, characterized in that, The sample analyzer also includes a sample dispensing component and a pipetting component disposed on the sample dispensing component. The sample dispensing component is used to move the pipetting component between different operating positions to aspirate or discharge the sample to be tested. The sample analyzer also includes a pressure detection mechanism and a processor. The pressure detection mechanism is used to detect the pressure inside the pipetting component, and the processor is used to receive the pressure signal output by the pressure detection mechanism and determine whether the pipetting component is leaking based on the pressure signal.

5. The sample analyzer according to claim 1, characterized in that, The sample analyzer also includes a sample dispensing component and a pipetting component disposed on the sample dispensing component. The sample dispensing component is used to move the pipetting component between different operating positions to aspirate or discharge the sample to be tested. The sample analyzer also includes a dropper tray, which is located below the pipetting component and moves with the pipetting component to collect the sample to be tested that drips from the pipetting component.

6. The sample analyzer according to claim 1, characterized in that, The sample analyzer also includes a scheduling mechanism, a clamping mechanism, an opening and closing mechanism, and a suction device; The scheduling mechanism is used to schedule the sample container to be aspirated on the sample holder to the open position; The clamping mechanism is used to clamp or release the body of the sample container located in the open position; The opening and closing mechanism is used to clamp the lid of the sample container located in the opening position, so as to open or close the sample container. The suction device includes a suction port that faces the opening of the main body of the sample container located in the open position.

7. The sample analyzer according to any one of claims 1-6, characterized in that, The one or more baffles include a first baffle and a second baffle; When the sample holder is located in the sample-to-absorption position inside the housing assembly, the first baffle blocks the opening, and the second baffle avoids the opening; When the sample holder is located in the loading position outside the housing assembly, the second baffle blocks the opening, and the first baffle avoids the opening.

8. The sample analyzer according to claim 7, characterized in that, The second baffle is connected to the sample holder and moves synchronously; During the process of the sample injection mechanism moving from the inside of the housing assembly to the outside of the housing assembly, the second baffle and the sample holder move synchronously from the inside of the housing assembly to the opening, and the first baffle moves to avoid the opening, so that the sample holder extends to the outside of the housing assembly and the second baffle blocks the opening; During the process of the sample injection mechanism moving from the outside of the housing assembly to the inside of the housing assembly, the second baffle and the sample holder move synchronously from the opening into the inside of the housing assembly, so that the sample holder and the second baffle enter the inside of the housing assembly, and the first baffle moves to block the opening.

9. The sample analyzer according to claim 7, characterized in that, The inner surface of the shell has a sealing mating surface, which surrounds the opening and is used to seal with the first baffle or the second baffle. The first baffle rotates relative to the shell, and the rotation center line of the first baffle is parallel to the sealing mating surface, so as to cover or avoid the opening.

10. The sample analyzer according to claim 9, characterized in that, The rotational stroke of the first baffle is greater than 0° and does not exceed 90°.

11. The sample analyzer according to claim 7, characterized in that, The inner surface of the shell has a sealing mating surface, which surrounds the opening and is used to seal with the first baffle or the second baffle. The sample injection mechanism includes a driving mechanism for driving the first baffle to translate. The translational displacement of the first baffle includes a displacement component in a first direction and a displacement component in a second direction. The first direction is perpendicular to the sealing mating surface, and the second direction is parallel to the sealing mating surface.

12. The sample analyzer according to claim 7, characterized in that, The inner surface of the shell has a sealing mating surface, which surrounds the opening and is used to seal with the first baffle or the second baffle. The sample holder and the second baffle move linearly along a first direction, which is perpendicular to the sealing mating surface; The sample introduction mechanism also includes a power mechanism, which drives the sample holder and the second baffle to move linearly along a first direction.

13. The sample analyzer according to claim 7, characterized in that, The sample injection mechanism further includes a linkage mechanism, which is used to link the first baffle and the second baffle so that, during the movement of the second baffle from the inside of the housing assembly to the opening, the first baffle moves to avoid the opening, or, during the movement of the second baffle from the opening to the inside of the housing assembly, the first baffle moves to block the opening.

14. The sample analyzer according to claim 13, characterized in that, The sample holder and the second baffle move linearly along a first direction; the sample injection mechanism also includes a shaft connected to the first baffle. The linkage mechanism includes a limiting member and a first reversing component. The movement of the second baffle and the sample seat drives the limiting member to move linearly along the first direction. The first reversing component connects the limiting member and the shaft, and is used to convert the linear movement of the limiting member along the first direction into the rotation of the shaft, thereby driving the first baffle to rotate through the shaft.

15. The sample analyzer according to claim 14, characterized in that, The sample analyzer also includes a support stage and a shaft frame; The first baffle, the second baffle, and the sample holder are all disposed on the top side of the support platform; The shaft bracket is connected to the support platform, and the shaft bracket has at least two shaft holes arranged coaxially in the height direction of the sample analyzer, through which the shaft portion rotatably passes.

16. The sample analyzer according to claim 12 or 14, characterized in that, The sample analyzer also includes a support platform and a track; The first baffle, the second baffle, and the sample holder are all disposed on the top side of the support platform; The track extends linearly along a first direction on the top surface of the support platform, and the track is used to guide the linear movement of the sample holder and / or the second baffle along the first direction.

17. The sample analyzer according to claim 14, characterized in that, The linkage mechanism further includes an elastic element; the movement stroke of the second baffle and the sample seat in the first direction includes a first stroke segment and a second stroke segment, wherein the first stroke segment is located on the side closer to the interior of the housing assembly, and the second stroke segment is located on the side closer to the opening; During the first stroke segment, the elastic member applies a spring force to the limiting member in the direction of the opening, and at least one of the sample seat and the second baffle abuts against the limiting member along the first direction under the action of the spring force, so that the second baffle, the sample seat and the limiting member are linked together. During the second stroke segment, the elastic element is in its natural state, and both the sample seat and the second baffle are separated from the limiting element, so that while the sample seat and the second baffle are moving, the linkage mechanism remains stationary.

18. The sample analyzer according to claim 14, characterized in that, The first reversing assembly includes a ring-shaped first flexible transmission element, and the sample analyzer also includes a wheel. The first flexible transmission member has its two ends wrapped around the shaft and the wheel. The limiting member is connected to the first flexible transmission member. The limiting member drives the first flexible transmission member to move, so as to drive the shaft to rotate through the first flexible transmission member.

19. The sample analyzer according to claim 12, characterized in that, The power mechanism includes a motor, a second reversing assembly, and a connecting structure. The motor has a power output shaft. At least one of the sample holder and the second baffle is connected to the second reversing assembly through the connecting structure. The second reversing assembly is used to convert the rotation of the power output shaft into linear motion of the connecting structure along a first direction, thereby causing the connecting structure to drive the sample holder and the second baffle to move linearly along the first direction.

20. The sample analyzer according to claim 19, characterized in that, The second reversing assembly includes a ring-shaped second flexible transmission element and a guide wheel; The two ends of the second flexible transmission member are wound around the guide wheel and the power output shaft. The connecting structure is connected to the second flexible transmission member. During the rotation of the power output shaft, the second flexible transmission member is driven to move. During the movement of the second flexible transmission member, the connecting structure is driven to move linearly along the first direction.

21. The sample analyzer according to claim 19, characterized in that, The second reversing assembly includes a rack and at least one gear; The rack is connected to the connecting structure, the at least one gear meshes with the rack, the power output shaft drives the at least one gear to rotate, and through the at least one gear, drives the rack to move linearly along the first direction.

22. The sample analyzer according to claim 7, characterized in that, The sample analyzer also includes a force application mechanism and a linkage mechanism; At least one of the first baffle, the second baffle, the sample holder, and the linkage mechanism is connected to the force-applying mechanism, which is used to drive the first baffle, the second baffle, and the sample holder to move under the action of external force.

23. The sample analyzer according to any one of claims 1-6, characterized in that, The opening is used to form an injection channel for emergency samples; the sample holder is used to hold an emergency sample container; and / or, the opening is used to form an injection channel for regular samples, and the sample holder is used to hold a regular sample container.

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