Retention spraying insecticidal composition and application thereof

Abstract

The invention relates to a sanitary insecticide, in particular to a retention spraying insecticidal composition and application thereof. The composition comprises a component A and a component B in a weight ratio of (5: 1)-(1: 5), the component A is 4-trifluoromethyl nicotinamide, and the component B is any one of meperfluthrin, cis-cypermethrin, beta-cypermethrin, beta-cyhalothrin, beta-cyhalothrin and bifenthrin. The composition disclosed by the invention is compounded and processed into wettable powder, water dispersible granules or a suspending agent according to a scientific ratio, does not use an organic solvent, is more environment-friendly, and has an excellent lethal effect on public health pests. The compound insecticide is applied in a retention spraying mode, has a remarkable synergistic effect on prevention and treatment of public health pests, can reduce the application amount of the insecticide, saves the cost, delays the generation of pest resistance to drugs, and is widely applied to hotels, schools, factories, families, farmers, farms and public places.

Description

Technical Field

[0001] This invention relates to a sanitary insecticide, specifically to a residual spray insecticide composition and its application. Background Technology

[0002] 4-Trifluoromethylnicotinamide is a metabolite of flonicamid and possesses insecticidal activity. It binds to and inhibits nicotinamide enzymes in insects. Nicotinamide enzymes are expressed in spinal cord tension receptor neurons / stringer neurons and are the ninth molecular target in the insect nervous system. Inhibition of nicotinamide enzymes by 4-trifluoromethylnicotinamide leads to the accumulation of the substrate nicotinamide, thereby overactivating TRPV ion channels and producing poisoning symptoms.

[0003] Currently, pyrethroid insecticides are prevalent among residual spray products used in the external environment. Long-term, excessive use of pyrethroid insecticides, or the prolonged use of a single product, can lead to significant resistance in pests such as mosquitoes, flies, and cockroaches, and in recent years, a general decline in their effectiveness has also been observed. Therefore, there is a need for environmentally friendly and highly effective pesticide compound formulations to delay the development of pesticide resistance in sanitary pests.

[0004] Currently, mixing different pesticides is a common method to delay the development of resistance. By screening formulas and obtaining reasonable formulations, the amount of pesticides used can be effectively reduced, costs can be lowered, and the development of pesticide resistance in pests can be delayed. However, the rationale behind mixing requires further exploration and research. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to address the shortcomings of the prior art by providing a residual spray insecticide composition and its application.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: A residual spray insecticide composition comprising component A and component B in a weight ratio of 5:1 to 1:5, wherein component A is 4-trifluoromethylnicotinamide and component B is any one of chlorpyrifos, cis-cypermethrin, lambda-cyhalothrin, lambda-cyhalothrin, lambda-cyhalothrin, and bifenthrin.

[0007] Furthermore, in the composition, When component A is 4-trifluoromethylnicotinamide and component B is chlorfluazuron, the weight ratio of component A to component B is 5:1 to 1:1. When component A is 4-trifluoromethylnicotinamide and component B is cis-cypermethrin, the weight ratio of component A to component B is 3:1 to 1:5. When component A is 4-trifluoromethylnicotinamide and component B is high-efficiency cypermethrin, the weight ratio of component A to component B is 3:1 to 1:3. When component A is 4-trifluoromethylnicotinamide and component B is lambda-cyhalothrin, the weight ratio of component A to component B is 3:1 to 1:2. When component A is 4-trifluoromethylnicotinamide and component B is high-efficiency cypermethrin, the weight ratio of component A to component B is 5:1 to 1:5. When component A is 4-trifluoromethylnicotinamide and component B is bifenthrin, the weight ratio of component A to component B is 3:1 to 1:4.

[0008] An application of the residual spray insecticide composition, wherein the composition is used in the control of public health pests.

[0009] The public health pests mentioned refer to one or more of the following: mosquitoes, flies, cockroaches, and fleas.

[0010] A residual spray insecticide, the formulation comprising the composition described above.

[0011] The formulation is a wettable powder, a water-dispersible granule, or a suspension.

[0012] When the formulation is a wettable powder, the weight percentages are: 5% to 30% of the composition, 1% to 10% of the dispersant, 1% to 5% of the wetting agent, and filler to make up to 100%.

[0013] The formulation is a water-dispersible granule, comprising, by weight percentage: 10%–50% of the composition, 1%–10% of the dispersant, 1%–5% of the wetting agent, 1%–10% of the disintegrant, 0.1%–1% of the binder, and filler to 100%.

[0014] When the formulation is a suspension, it comprises, by weight percentage: 5%–30% of the composition, 1%–10% of the dispersant, 1%–5% of the wetting agent, 0.1%–1% of the thickener, 0.1%–1% of the preservative, 3%–10% of the antifreeze, 0.1%–0.5% of the defoamer, and deionized water to bring the total to 100%.

[0015] The wettable powder is prepared by adding the composition, wetting agent, dispersant and filler into a food processor according to the specified ratio, mixing them evenly, and then pulverizing them in an air jet mill.

[0016] The water-dispersible granules are prepared by adding the composition, wetting agent, dispersant, disintegrant, binder and filler into a food processor according to the specified ratio, mixing them evenly, then pulverizing them in an air jet mill. The powder is then placed in a beaker with an appropriate amount of water, stirred and kneaded, extruded and granulated using a granulator, and then dried to obtain the final product.

[0017] The suspension is prepared as follows: According to the stated proportions, the insecticidal composition, wetting agent, dispersant, antifreeze, preservative, defoamer, and deionized water are added to a beaker and mixed thoroughly. The mixture is then transferred to a sand mill, where zirconia beads are added and milled for 2-3 hours. A thickener is added, and milling continues for 0.5 hours to achieve a particle size D... 95 The product can be obtained by controlling the micrometer size to below 5 micrometers and filtering out the zirconium oxide beads.

[0018] The dispersant is selected from any one of sodium polycarboxylate, sodium lignosulfonate, sodium alkylnaphthaleneformaldehyde condensate, sodium naphthalenesulfonate, sodium alkylbenzenesulfonate, sodium naphthalenesulfonateformaldehyde condensate, polyether sulfate, polyarylphenyl ether ammonium phosphate, sodium succinate diester sulfonate, and sodium octylphenol polyoxyethylene ether sulfonate, or a mixture of two or more in any proportion.

[0019] The wetting agent is selected from any one of sodium dinonyl phosphate, sodium dihydroxybiphenyl sulfonate, sodium dodecyl aminopropionate, sodium dihexyl succinate sulfonate, sodium tridecyl sulfate, sodium alkyl succinate sulfonate, sodium dodecyl sulfate, styrene-based powder BX, and sodium dodecylbenzene sulfonate, or a mixture of two or more in any proportion.

[0020] The filler is selected from any one of kaolin, clay, corn starch, attapulgite, talc, diatomaceous earth, and bentonite, or a mixture of two or more in any proportion.

[0021] The disintegrant is selected from any one of sodium chloride, ammonium chloride, ammonium sulfate, sodium carbonate, sodium carboxymethyl starch, and microcrystalline cellulose.

[0022] The binder is selected from any one of carboxypropyl cellulose, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, and sodium carboxymethyl cellulose.

[0023] The thickener is selected from any one of xanthan gum, polyacrylic acid, magnesium aluminum silicate, chitosan, and guar gum, or a mixture of two or more in any proportion.

[0024] The preservative is selected from any one of potassium sorbate, sodium benzoate, Kathon, and benzisothiazolinone.

[0025] The antifreeze is selected from any one of ethylene glycol, propylene glycol, glycerol, and urea.

[0026] The defoamer is selected from any one of dipalmitoyl ethylenediamine, isoamyl stearate, dimethyl silicone oil, hexadecyl alcohol, and polyether-modified organosilicon.

[0027] An application of the residual spray insecticide, wherein the formulation is used in the prevention and control of public health pests.

[0028] In the above technical solution, the public health pests refer to mosquitoes, flies, cockroaches, and fleas; the application sites include hotels, schools, factories, homes, farms, breeding farms, and public places.

[0029] In the above technical solution, the insecticide containing 4-trifluoromethylnicotinamide is applied in the form of residual spraying when controlling public health pests. The wettable powder is diluted with water 100-200 times, the water-dispersible granules are diluted with water 100-200 times, and the suspension is diluted with water 100-200 times before being sprayed on the surfaces of walls, doors, windows, ceilings, and furniture, so that the compound insecticide remains on the surface of the above objects, causing the sanitary pests to die after contact.

[0030] The advantages of the technical solution of this invention are: The insecticide of this invention is formulated by compounding 4-trifluoromethylnicotinamide with any one of chlorpyrifos, cis-cypermethrin, lambda-cyhalothrin, lambda-cyhalothrin, lambda-cyhalothrin, and bifenthrin into wettable powder, water-dispersible granules, or suspension concentrate. It does not use organic solvents, is more environmentally friendly, and has a significant synergistic effect in controlling public health pests (mosquitoes, flies, cockroaches, fleas). It can reduce the amount of pesticide used, save costs, and delay the development of pesticide resistance in pests. Detailed Implementation

[0031] The following describes in detail the specific embodiments of the technical solution of the present invention, but the present invention is not limited to the following description.

[0032] This invention combines 4-trifluoromethylnicotinamide with any one of cyhalothrin, cis-cypermethrin, lambda-cyhalothrin, lambda-cyhalothrin, lambda-cyhalothrin, and bifenthrin. This not only improves the control effect on sanitary pests and delays the development of pesticide resistance in sanitary pests, but also reduces the environmental harm caused by organic solvents, making it more environmentally friendly. The sanitary insecticidal composition of this invention has good insecticidal effect, synergistic effect when combined, and is less likely to produce pesticide resistance.

[0033] Unless otherwise specified, all percentages in the following examples refer to weight percentages: The present invention will now be described in conjunction with specific embodiments: Formulation Example 1: 24% 4-Trifluoromethylnicotinamide·Cyfluthrin Wettable Powder 4-Trifluoromethylnicotinamide 20%, chlorpyrifos 4%, sodium lignosulfonate 4%, sodium polycarboxylate 6%, sodium alkyl succinate sulfonate 3%, diatomaceous earth 20%, kaolin to 100%.

[0034] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 24% 4-trifluoromethylnicotinamide·chlorfluazuron wettable powder.

[0035] Formulation Example 2: 5% 4-Trifluoromethylnicotinamide·Cyfluthrin Wettable Powder 4-Trifluoromethylnicotinamide 2.5%, chlorpyrifos 2.5%, sodium alkylnaphthalene condensate sulfonate 8%, sodium naphthalene sulfonate 1%, sodium dodecyl sulfate 3%, clay 25%, kaolin to 100%.

[0036] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 5% 4-trifluoromethylnicotinamide·chlorfenapyr wettable powder.

[0037] Formulation Example 3: 20% 4-Trifluoromethylnicotinamide·cis-cypermethrin wettable powder 15% 4-trifluoromethylnicotinamide, 5% cis-cypermethrin, 2% sodium naphthalenesulfonate, 5% sodium alkylbenzenesulfonate, 5% sodium dihydroxybiphenylsulfonate, and corn starch to make up to 100%.

[0038] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 20% 4-trifluoromethylnicotinamide·cis-cypermethrin wettable powder.

[0039] Formulation Example 4: 30% 4-Trifluoromethylnicotinamide·cis-cypermethrin wettable powder 4-Trifluoromethylnicotinamide 6%, cis-cypermethrin 24%, sodium naphthalenesulfonic acid formaldehyde condensate 6%, sodium dodecylaminopropionate 4%, bentonite 25%, talc to make up to 100%.

[0040] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 30% 4-trifluoromethylnicotinamide·cis-cypermethrin wettable powder.

[0041] Formulation Example 5: 30% 4-Trifluoromethylnicotinamide·High-efficiency cypermethrin wettable powder 4-Trifluoromethylnicotinamide 20%, high-efficiency cypermethrin 10%, polyether sulfate salt 7%, sodium alkylbenzene sulfonate 2%, sodium tridecyl sulfate 2%, attapulgite to 100%.

[0042] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 30% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin wettable powder.

[0043] Formulation Example 6: 15% 4-Trifluoromethylnicotinamide·High-efficiency cypermethrin wettable powder 4-Trifluoromethylnicotinamide 5%, high-efficiency cypermethrin 10%, polyarylphenyl ether ammonium phosphate 5%, sodium succinate diester sulfonate 5%, sodium dinonyl phosphate 2%, sodium dodecylbenzene sulfonate 2%, bentonite 10%, kaolin to make up to 100%.

[0044] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 15% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin wettable powder.

[0045] Formulation Example 7: 18% 4-Trifluoromethylnicotinamide·High-efficiency cyhalothrin wettable powder 12% 4-trifluoromethyl nicotinamide, 6% high-efficiency cyhalothrin, 5% polyether sulfate salt, 5% sodium octylphenol polyoxyethylene ether sulfonate, 2% BX powder, 2% sodium dodecylbenzene sulfonate, 10% bentonite, and clay to make up to 100%.

[0046] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 18% 4-trifluoromethylnicotinamide·high-efficiency cyhalothrin wettable powder.

[0047] Formulation Example 8: 12% 4-Trifluoromethylnicotinamide·High-efficiency cyhalothrin wettable powder 4-Trifluoromethylnicotinamide 4%, high-efficiency cyhalothrin 8%, sodium naphthalenesulfonic acid formaldehyde condensate 8%, sodium dihexyl succinate sulfonate 2%, kaolin to 100%.

[0048] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 12% 4-trifluoromethylnicotinamide·high-efficiency cyhalothrin wettable powder.

[0049] Formulation Example 9: 24% 4-Trifluoromethylnicotinamide·High-efficiency cypermethrin wettable powder 4-Trifluoromethylnicotinamide 20%, high-efficiency cypermethrin 4%, sodium naphthalenesulfonate 3%, sodium succinate diester sulfonate 4%, sodium dinonyl phosphate 5%, corn starch 20%, attapulgite clay to 100%.

[0050] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 24% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin wettable powder.

[0051] Formulation Example 10: 15% 4-Trifluoromethylnicotinamide·High-efficiency cypermethrin wettable powder 4-Trifluoromethylnicotinamide 3%, high-efficiency cypermethrin 12%, sodium lignosulfonate 10%, BX powder 1%, sodium dodecylaminopropionate 3%, bentonite to 100%.

[0052] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 15% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin wettable powder.

[0053] Formulation Example 11: 20% 4-Trifluoromethylnicotinamide·Bifenthrin Wettable Powder 4-Trifluoromethylnicotinamide 15%, bifenthrin 5%, sodium naphthalenesulfonic acid formaldehyde condensate 2%, sodium octylphenol polyoxyethylene ether sulfonate 6%, sodium dodecyl sulfate 5%, talc 20%, kaolin to 100%.

[0054] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 20% 4-trifluoromethylnicotinamide·bifenthrin wettable powder.

[0055] Formulation Example 12: 10% 4-Trifluoromethylnicotinamide·Bifenthrin Wettable Powder 4-Trifluoromethylnicotinamide 2.5%, bifenthrin 7.5%, polyarylphenyl ether ammonium phosphate 2%, sodium naphthalenesulfonate 3%, sodium dinonyl phosphate 1%, sodium dodecyl sulfate 3%, clay to 100%.

[0056] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, and then mixed again to obtain 10% 4-trifluoromethylnicotinamide·bifenthrin wettable powder.

[0057] Formulation Example 13: 50% 4-Trifluoromethylnicotinamide·Cyfluthrin Water Dispersible Granules 4-Trifluoromethylnicotinamide 40%, chlorpyrifos 10%, sodium lignosulfonate 6%, sodium naphthalenesulfonic acid formaldehyde condensate 4%, sodium dodecyl sulfate 5%, sodium chloride 10%, carboxypropyl cellulose 0.5%, kaolin to 100%.

[0058] The ingredients are mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 50% 4-trifluoromethylnicotinamide·chlorfenapyr water-dispersible granules.

[0059] Formulation Example 14: 20% 4-Trifluoromethylnicotinamide·Cyfluthrin Water Dispersible Granules 4-Trifluoromethylnicotinamide 15%, chlorfluazuron 5%, sodium alkylnaphthalene condensate sulfonate 10%, sodium tridecyl sulfate 1%, BX 2%, ammonium chloride 8%, polyvinylpyrrolidone 1%, clay 10%, corn starch to make up to 100%.

[0060] The ingredients are mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 20% 4-trifluoromethylnicotinamide·chlorfenapyr water-dispersible granules.

[0061] Formulation Example 15: 30% 4-Trifluoromethylnicotinamide·cis-cypermethrin water-dispersible granules 4-Trifluoromethylnicotinamide 20%, cis-cypermethrin 10%, sodium lignosulfonate 9%, sodium dihexyl succinate sulfonate 4%, ammonium sulfate 9%, polyvinyl alcohol 0.6%, attapulgite to 100%.

[0062] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 30% 4-trifluoromethylnicotinamide·cis-cypermethrin water-dispersible granules.

[0063] Formulation Example 16: 40% 4-Trifluoromethylnicotinamide·cis-cypermethrin water-dispersible granules 4-Trifluoromethylnicotinamide 32%, cis-cypermethrin 8%, sodium polycarboxylate 5%, sodium alkylbenzene sulfonate 3%, sodium dodecylbenzene sulfonate 1%, sodium dodecyl sulfate 2%, sodium carbonate 10%, polyethylene glycol 0.1%, diatomaceous earth to make up to 100%.

[0064] The ingredients are mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 40% 4-trifluoromethylnicotinamide·cis-cypermethrin water-dispersible granules.

[0065] Formulation Example 17: 24% 4-Trifluoromethylnicotinamide·High-efficiency Cypermethrin Water Dispersible Granules 4-Trifluoromethylnicotinamide 18%, high-efficiency cypermethrin 6%, sodium alkylnaphthalene condensate sulfonate 1%, sodium polycarboxylate 6%, sodium dodecyl sulfate 5%, sodium carboxymethyl starch 6%, sodium carboxymethyl cellulose 0.5%, corn starch 20%, attapulgite clay to 100%.

[0066] The formulation ingredients are mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 24% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin water-dispersible granules.

[0067] Formulation Example 18: 10% 4-Trifluoromethylnicotinamide·High-efficiency cypermethrin water-dispersible granules 4-Trifluoromethylnicotinamide 5%, high-efficiency cypermethrin 5%, sodium succinate diester sulfonate 5%, sodium polycarboxylate 4%, BX 5%, microcrystalline cellulose 10%, polyvinyl alcohol 0.2%, kaolin to 100%.

[0068] The ingredients are mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 10% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin water-dispersible granules.

[0069] Formulation Example 19: 30% 4-Trifluoromethylnicotinamide·High-efficiency cyhalothrin water-dispersible granules 15% 4-trifluoromethylnicotinamide, 15% lambda-cyhalothrin, 10% sodium lignosulfonate, 4% sodium dodecyl sulfate, 1% microcrystalline cellulose, 0.3% sodium carboxymethyl cellulose, and corn starch to make up to 100%.

[0070] The ingredients are mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 30% 4-trifluoromethylnicotinamide·high-efficiency cyhalothrin water-dispersible granules.

[0071] Formulation Example 20: 18% 4-Trifluoromethylnicotinamide·High-efficiency cyhalothrin water-dispersible granules 4-Trifluoromethylnicotinamide 6%, high-efficiency cyhalothrin 12%, sodium naphthalenesulfonate 3%, polyarylphenyl ether ammonium phosphate 5%, dinonyl phosphate 5%, ammonium chloride 4%, carboxypropyl cellulose 0.4%, diatomaceous earth to make up to 100%.

[0072] The formulation materials are mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 18% 4-trifluoromethylnicotinamide·high-efficiency cyhalothrin water-dispersible granules.

[0073] Formulation Example 21: 12% 4-Trifluoromethylnicotinamide·High-efficiency cypermethrin water-dispersible granules 4-Trifluoromethylnicotinamide 2%, high-efficiency cypermethrin 10%, sodium lignosulfonate 10%, sodium dihydroxybiphenyl sulfonate 2%, BX 2%, sodium carboxymethyl starch 10%, polyvinylpyrrolidone 0.1%, corn starch 15%, kaolin to 100%.

[0074] The formulation ingredients are mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 12% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin water-dispersible granules.

[0075] Formulation Example 22: 16% 4-Trifluoromethylnicotinamide·High-efficiency cypermethrin water-dispersible granules 4-Trifluoromethylnicotinamide 8%, high-efficiency cypermethrin 8%, sodium octylphenol polyoxyethylene ether sulfonate 8%, sodium dodecylaminopropionate 5%, sodium chloride 6%, polyethylene glycol 0.8%, attapulgite to 100%.

[0076] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 16% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin water-dispersible granules.

[0077] Formulation Example 23: 25% 4-Trifluoromethylnicotinamide·Bifenthrin Water Dispersible Granules 4-Trifluoromethylnicotinamide 5%, bifenthrin 20%, sodium polycarboxylate 5%, polyether sulfate 3%, sodium dinonyl phosphate 1%, sodium dodecylbenzenesulfonate 4%, sodium carbonate 10%, polyvinyl alcohol 0.4%, talc 5%, corn starch to make up to 100%.

[0078] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 25% 4-trifluoromethylnicotinamide·bifenthrin water-dispersible granules.

[0079] Formulation Example 24: 15% 4-Trifluoromethylnicotinamide·Bifenthrin Water Dispersible Granules 10% 4-trifluoromethylnicotinamide, 5% bifenthrin, 10% sodium salt of naphthalenesulfonic acid formaldehyde condensate, 4% sodium tridecyl sulfate, 6% ammonium sulfate, 1% polyvinylpyrrolidone, and kaolin to make up to 100%.

[0080] The ingredients were mixed evenly, pulverized using an ultra-micro airflow pulverizer, kneaded with a small amount of water, and then granulated and dried in a rotary granulator to obtain 15% 4-trifluoromethylnicotinamide·bifenthrin water-dispersible granules.

[0081] Formulation Example 25: 15% 4-Trifluoromethylnicotinamide·Cyfluthrin Suspension Concentrate 4-Trifluoromethylnicotinamide 10%, chlorfluazuron 5%, sodium octylphenol polyoxyethylene ether sulfonate 3%, sodium polycarboxylate 5%, sodium dihydroxybiphenyl sulfonate 2%, sodium alkyl succinate sulfonate 1%, xanthan gum 0.2%, magnesium aluminum silicate 0.8%, potassium sorbate 0.5%, ethylene glycol 10%, hexadecyl alcohol 0.3%, deionized water to 100%.

[0082] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 15% 4-trifluoromethylnicotinamide·chlorfenapyr ester suspension.

[0083] Formulation Example 26: 5% 4-Trifluoromethylnicotinamide·Cyfluthrin Suspension Concentrate 4-Trifluoromethylnicotinamide 4%, chlorpyrifos 1%, sodium succinate diester sulfonate 10%, sodium alkylnaphthalene condensate sulfonate 5%, xanthan gum 0.2%, polyacrylic acid 0.5%, sodium benzoate 1%, propylene glycol 5%, dimethyl silicone oil 0.1%, deionized water to 100%.

[0084] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 5% 4-trifluoromethylnicotinamide·chlorfenapyr ester suspension.

[0085] Formulation Example 27: 10% 4-Trifluoromethylnicotinamide·cis-cypermethrin suspension 4-Trifluoromethylnicotinamide 5%, cis-cypermethrin 5%, polyarylphenyl ether ammonium phosphate 1%, sodium polycarboxylate 5%, sodium dihydroxybiphenyl sulfonate 2%, sodium dodecylbenzene sulfonate 3%, chitosan 0.1%, Kathon 0.3%, glycerol 5%, dipalmitoyl ethylenediamine 0.5%, deionized water to 100%.

[0086] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 10% 4-trifluoromethylnicotinamide·cis-cypermethrin suspension.

[0087] Formulation Example 28: 30% 4-Trifluoromethylnicotinamide·cis-cypermethrin suspension 4-Trifluoromethylnicotinamide 5%, cis-cypermethrin 25%, polyether sulfate 5%, sodium lignosulfonate 3%, sodium dodecylaminopropionate 3%, guar gum 0.3%, magnesium aluminum silicate 0.7%, benzisothiazolinone 0.1%, urea 3%, polyether modified organosilicon 0.5%, deionized water to 100%.

[0088] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 30% 4-trifluoromethylnicotinamide·cis-cypermethrin suspension.

[0089] Formulation Example 29: 12% 4-Trifluoromethylnicotinamide·High-efficiency cypermethrin suspension 4-Trifluoromethylnicotinamide 3%, high-efficiency cypermethrin 9%, sodium lignosulfonate 10%, sodium dihexyl succinate sulfonate 4%, sodium alkyl succinate sulfonate 1%, xanthan gum 0.3%, potassium sorbate 0.5%, propylene glycol 8%, dimethyl silicone oil 0.3%, deionized water to 100%.

[0090] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 12% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin suspension.

[0091] Formulation Example 30: 18% 4-Trifluoromethylnicotinamide·High-efficiency Cypermethrin Suspension Concentrate 4-Trifluoromethylnicotinamide 12%, high-efficiency cypermethrin 6%, sodium naphthalenesulfonic acid formaldehyde condensate 8%, sodium dodecylaminopropionate 3%, polyacrylic acid 0.1%, magnesium aluminum silicate 0.5%, Kathon 0.1%, ethylene glycol 3%, isoamyl stearate 0.5%, deionized water to 100%.

[0092] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 18% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin suspension.

[0093] Formulation Example 31: 10% 4-Trifluoromethylnicotinamide·High-efficiency cyhalothrin suspension concentrate 4-Trifluoromethylnicotinamide 7.5%, high-efficiency cyhalothrin 2.5%, sodium alkylbenzene sulfonate 2%, sodium octylphenol polyoxyethylene ether sulfonate 6%, sodium alkyl succinate sulfonate 5%, xanthan gum 0.3%, benzisothiazolinone 0.2%, urea 4%, dimethyl silicone oil 0.1%, deionized water to 100%.

[0094] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 10% 4-trifluoromethylnicotinamide·high-efficiency cyhalothrin suspension.

[0095] Formulation Example 32: 6% 4-Trifluoromethylnicotinamide·High-efficiency cyhalothrin suspension concentrate 4-Trifluoromethylnicotinamide 4%, high-efficiency cyhalothrin 2%, polyether sulfate salt 3%, sodium alkylbenzene sulfonate 5%, sodium dihydroxybiphenyl sulfonate 5%, polyacrylic acid 0.2%, xanthan gum 0.2%, potassium sorbate 0.5%, ethylene glycol 8%, diether modified organosilicon 0.2%, deionized water to 100%.

[0096] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 6% 4-trifluoromethylnicotinamide·high-efficiency cyhalothrin suspension.

[0097] Formulation Example 33: 20% 4-Trifluoromethylnicotinamide·High-efficiency Cypermethrin Suspension Concentrate 4-Trifluoromethylnicotinamide 15%, high-efficiency cypermethrin 5%, sodium lignosulfonate 3%, polyether sulfate 6%, sodium tridecyl sulfate 5%, chitin 0.4%, Kathon 0.8%, glycerol 5%, dipalmitoyl ethylenediamine 0.2%, deionized water to 100%.

[0098] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 20% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin suspension.

[0099] Formulation Example 34: 30% 4-Trifluoromethylnicotinamide·High-efficiency Cypermethrin Suspension Concentrate 10% 4-Trifluoromethylnicotinamide, 20% lambda-cyhalothrin, 10% sodium naphthalenesulfonate, 1% sodium dodecyl sulfate, 4% sodium dihydroxybiphenylsulfonate, 0.2% xanthan gum, 0.5% benzisothiazolinone, 3% propylene glycol, 0.5% hexadecyl alcohol, and deionized water to bring the total to 100%.

[0100] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 30% 4-trifluoromethylnicotinamide·high-efficiency cypermethrin suspension.

[0101] Formulation Example 35: 16% 4-Trifluoromethylnicotinamide·Bifenthrin Suspension 4-Trifluoromethylnicotinamide 8%, Bifenthrin 8%, Sodium Alkylbenzene Sulfonate 8%, Sodium Dodecylaminopropionate 3%, Guar gum 0.2%, Xanthan gum 0.2%, Sodium Benzoate 0.4%, Ethylene Glycol 8%, Dimethyl Silicone Oil 0.3%, Deionized Water to 100%.

[0102] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 16% 4-trifluoromethylnicotinamide·bifenthrin suspension.

[0103] Formulation Example 36: 24% 4-Trifluoromethylnicotinamide·Bifenthrin Suspension 4-Trifluoromethylnicotinamide 8%, bifenthrin 16%, polyether sulfate 1%, sodium naphthalene sulfonate formaldehyde condensate 8%, sodium dihexyl succinate sulfonate 5%, magnesium aluminum silicate 0.1%, xanthan gum 0.3%, potassium sorbate 0.5%, propylene glycol 10%, polyether modified organosilicon 0.5%, deionized water to 100%.

[0104] The formulation materials are mixed evenly and then sand-milled until the particle size is less than 5 micrometers to obtain 24% 4-trifluoromethylnicotinamide·bifenthrin suspension.

[0105] Application Example 1: Indoor Residual Efficacy Test for Mosquito and Fly Control Experimental target: Culex pipiens pallens, female adult mosquitoes that did not feed on blood on the 3rd to 5th day after emergence; Houseflies, adults on the 3rd to 4th day after emergence, half male and half female; Test method: Refer to GB / T 13917.1-2009 for residual spraying test; Experimental treatment: The total concentration of the active ingredients in formulations 1, 3, 5, 7, 9, and 11 was diluted with water to 500 mg / L. Control sample 1: 10% 4-trifluoromethylnicotinamide wettable powder diluted to 500 mg / L; Control sample 2: 10% chlorpyrifos wettable powder diluted to 500 mg / L; Control sample 3: 10% cis-cypermethrin wettable powder diluted to 500 mg / L; Control sample 4: 10% high-efficiency cypermethrin wettable powder diluted to 500 mg / L; Control sample 5: 10% high-efficiency cyhalothrin wettable powder diluted to 500 mg / L; Control sample 6: 10% high-efficiency cypermethrin wettable powder diluted to 500 mg / L; Control sample 7: 10% bifenthrin wettable powder diluted to 500 mg / L; Experimental results: Table 1. Efficacy tests of formulation examples 1, 3, 5, 7, 9, and 11 against mosquitoes and flies.

[0106] As shown in Table 1, formulation example 1 exhibited better knockdown effects against Culex pipiens pallens and houseflies than its corresponding single-agent control samples 1 and 2, and its mortality rate was also better than that of the single-agent control samples. Similarly, formulation examples 3, 5, 7, 9, and 11 showed better knockdown effects and mortality rates against Culex pipiens pallens and houseflies than their corresponding single-agent control samples. This demonstrates that the combination of 4-trifluoromethylnicotinamide with cypermethrin, cis-cypermethrin, lambda-cyhalothrin, lambda-cyhalothrin, lambda-cyhalothrin, and bifenthrin, applied via residual spraying, provides good control of Culex pipiens pallens and houseflies.

[0107] Application Example 2: Indoor Residual Efficacy Test for Controlling Cockroaches Experimental target: German cockroach, 10-15 day old adults, half male and half female; Test method: Refer to GB / T 13917.1-2009 for residual spraying test; Test treatment: The total concentration of the active ingredient in formulations 13, 15, 17, 19, 21, and 23 was diluted with water to 500 mg / L. Control sample 8: 10% 4-trifluoromethylnicotinamide water-dispersible granules diluted to 500 mg / L; Control sample 9: 10% chlorpyrifos water-dispersible granules diluted to 500 mg / L; Control sample 10: 10% cis-cypermethrin water-dispersible granules diluted to 500 mg / L; Control sample 11: 10% high-efficiency cypermethrin water-dispersible granules diluted to 500 mg / L; Control sample 12: 10% high-efficiency cyhalothrin water-dispersible granules diluted to 500 mg / L; Control sample 13: 10% high-efficiency cypermethrin water-dispersible granules diluted to 500 mg / L; Control sample 14: 10% bifenthrin water-dispersible granules diluted to 500 mg / L; Experimental results: Table 2. Efficacy tests of formulation examples 13, 15, 17, 19, 21, and 23 against the German cockroach.

[0108] As shown in Table 2, formulations 13, 15, 17, 19, 21, and 23 showed significant knockdown effects against German cockroaches within 0.5 hours, far exceeding control samples 8-14. Furthermore, the knockdown rate against German cockroaches reached 100% within 2 hours, also better than control samples 8-14. The 72-hour mortality rate of formulations 13, 15, 17, 19, 21, and 23 against German cockroaches was better than the control single-agent samples. This demonstrates that the combination of 4-trifluoromethylnicotinamide with cypermethrin, cis-cypermethrin, lambda-cyhalothrin, lambda-cyhalothrin, lambda-cyhalothrin, and bifenthrin, applied via residual spraying, provides excellent control of German cockroaches.

[0109] Application Example 3: Indoor Residual Efficacy Test of Flea Control Experimental target: Indo-rat flea, 3-10 day old adults, half male and half female; Test method: Refer to GB / T 13917.1-2009 for residual spraying test; Test treatment: The total concentration of the active ingredient in formulations 25, 27, 29, 31, 33, and 35 was diluted with water to 500 mg / L. Control sample 15: 10% 4-trifluoromethylnicotinamide suspension diluted to 500 mg / L; Control sample 16: 10% chlorpyrifos suspension diluted to 500 mg / L; Control sample 17: 10% cis-cypermethrin suspension diluted to 500 mg / L; Control sample 18: 10% high-efficiency cypermethrin suspension diluted to 500 mg / L; Control sample 19: 10% high-efficiency cyhalothrin suspension diluted to 500 mg / L; Control sample 20: 10% high-efficiency cypermethrin suspension diluted to 500 mg / L; Control sample 21: 10% bifenthrin suspension diluted to 500 mg / L; Experimental results: Table 3. Efficacy tests of formulation examples 25, 27, 29, 31, 33, and 35 against *Rhizoctonia solani*.

[0110] As shown in Table 3, formulations 25, 27, 29, 31, 33, and 35 exhibited significant knockdown effects against *Rhizoctonia solani* within 0.5 hours, far exceeding control samples 15-21. Formulations 25, 27, 29, 31, 33, and 35 all achieved a 100% knockdown rate against *Rhizoctonia solani* within 1 hour, also superior to control samples 15-21. Furthermore, formulations 25, 27, 29, 31, 33, and 35 showed better mortality rates against *Rhizoctonia solani* within 24 hours than control samples 15-21. This demonstrates that the combination of 4-trifluoromethylnicotinamide with cypermethrin, cis-cypermethrin, lambda-cyhalothrin, lambda-cyhalothrin, lambda-cyhalothrin, and bifenthrin, applied via residual spraying, provides excellent control of *Rhizoctonia solani*.

[0111] Application Example 4: Retention Efficacy Test of Three Different Absorption Contact Surfaces Experimental target: Culex pipiens pallens, female adult mosquitoes that did not feed on blood on the 3rd to 5th day after emergence; Houseflies, adults on the 3rd to 4th day after emergence, half male and half female; German cockroach, adults aged 10-15 days, half male and half female; The Indian rat flea, adults aged 3 to 10 days, half male and half female; Test method: Refer to GB / T 13917.1-2009, residual spray test, test once every 15 days, and evaluate based on the duration (day) of mortality rate greater than 70% in 24h (72h for cockroaches).

[0112] Test equipment plate surface: non-absorbent surface - glass surface, duration ≥90d is rated A, duration ≥60d is rated B; Semi-absorbent surfaces – clear coat finishes, rated A for duration ≥ 60 days, and B for duration ≥ 45 days; Absorbing surfaces – lime surfaces (mosquitoes, flies, fleas), cement surfaces (cockroaches); a duration of ≥45 days is rated as Grade A, and a duration of ≥30 days is rated as Grade B. Experimental treatment: The total concentration of the active ingredient in formulations 2, 4, 6, 8, 10, and 12 was diluted with water to 500 mg / L. Control sample 1: 10% 4-trifluoromethylnicotinamide wettable powder diluted to 500 mg / L; Control sample 2: 10% chlorpyrifos wettable powder diluted to 500 mg / L; Control sample 3: 10% cis-cypermethrin wettable powder diluted to 500 mg / L; Control sample 4: 10% high-efficiency cypermethrin wettable powder diluted to 500 mg / L; Control sample 5: 10% high-efficiency cyhalothrin wettable powder diluted to 500 mg / L; Control sample 6: 10% high-efficiency cypermethrin wettable powder diluted to 500 mg / L; Control sample 7: 10% bifenthrin wettable powder diluted to 500 mg / L; Experimental results: Table 4 Retention efficacy test on non-absorbent surfaces (glass surfaces) of formulation examples 2, 4, 6, 8, 10, and 12

[0113] Table 5 Retention efficacy test on semi-absorbent surfaces (varnish surface) of formulation examples 2, 4, 6, 8, 10, and 12

[0114] Table 6 Retention efficacy tests on absorbent surfaces (lime / cement surfaces) of formulation examples 2, 4, 6, 8, 10, and 12

[0115] The test results in the table above show that, in tests conducted on three different absorption contact surfaces, the duration of action against Culex pipiens pallens, houseflies, German cockroaches, and spp. fleas in the formulations of this invention (Examples 2, 4, 6, 8, 10, and 12) was rated A for all targets, while the duration of action against targets in controls 1-7 was rated B. This invention demonstrates better comprehensive control efficacy against different targets on three different absorption contact surfaces than the controls, and its retention effect is also superior.

[0116] Application Example 5: Outdoor Efficacy Comparison Test for Fly Control Test target: fly Experimental method: The walls and floors of the breeding farm were selected as test subjects and divided into zones. The agent was sprayed on the surface of the walls and floors, and the fly density reduction rate of each treatment group was recorded after 1 day, 2 days and 3 days. Experimental treatment: Formulations 26, 28, 30, 32, 34, and 36 were diluted 100 times with water, with a dosage of 20 mg of active ingredient / m³. 2 ; Control sample 22: Commercially available 15% bifenthrin suspension diluted 100 times, dosage 20mg active ingredient / m³ 2 ; Control sample 23: Commercially available 6% high-efficiency cypermethrin + 4% propoxur suspension diluted 100 times, dosage 20mg active ingredient / m³ 2 ; Experimental results: Table 7. Comparative outdoor efficacy tests of formulations 26, 28, 30, 32, 34, and 36 against flies.

[0117] The results showed that formulations 26, 28, 30, 32, 34, and 36 of this invention exhibited significant control effects on flies, with a density reduction rate exceeding 50% after 1 day and over 95% after 3 days, both superior to control formulations 22 and 23. This demonstrates that the residual spraying method using a combination of 4-trifluoromethylnicotinamide and cypermethrin, cis-cypermethrin, lambda-cyhalothrin, lambda-cyhalothrin, lambda-cyhalothrin, and bifenthrin provides effective control.

[0118] Application Example 6: Determination of the co-toxicity coefficient of 4-trifluoromethylnicotinamide combined with other active ingredients in Culex pipiens pallens mosquitoes. Test target: Culex pipiens pallens Test method: In accordance with the guidelines for indoor bioassay of pesticides, Part 1: Contact activity test, the activity of Culex pipiens pallens was determined by the drop method NY / T1154.1-2006.

[0119] The median lethal dose (LD50) was calculated using linear weighted regression. 50 The co-toxicity coefficient was calculated with reference to Sun Yunpei's method.

[0120] Table 8. Determination of co-toxicity coefficients of 4-trifluoromethylnicotinamide and chlorpyrifos (for Culex pipiens pallens)

[0121] As shown in Table 8, when the ratio of 4-trifluoromethylnicotinamide to chlorpyrifos is 5:1 to 1:1, the co-toxicity coefficient against Culex pipiens pallens is greater than 120, indicating a significant synergistic effect.

[0122] Table 9. Determination of co-toxicity coefficient between 4-trifluoromethylnicotinamide and lambda-cypermethrin (for Culex pipiens pallens)

[0123] As shown in Table 9, when the ratio of 4-trifluoromethylnicotinamide to high-efficiency cypermethrin is 3:1 to 1:3, the co-toxicity coefficient against Culex pipiens pallens is greater than 120, indicating a significant synergistic effect.

[0124] Table 10. Optimal co-toxicity coefficients of 4-trifluoromethylnicotinamide with other active ingredient B (for Culex pipiens pallens).

[0125] As shown in Table 10, the optimal ratio of 4-trifluoromethylnicotinamide to the other active ingredient B has a co-toxicity coefficient of over 120, indicating a significant synergistic effect.

[0126] The above examples are merely illustrative of the technical concept and features of the present invention and should not be construed as limiting the scope of protection of the present invention. All equivalent transformations or modifications made in accordance with the essence of the present invention should be included within the scope of protection of the present invention.

Claims

1. A residual spray insecticide composition, characterized in that: The composition comprises component A and component B in a weight ratio of 5:1 to 1:5, wherein component A is 4-trifluoromethylnicotinamide and component B is any one of chlorpyrifos, cis-cypermethrin, lambda-cyhalothrin, lambda-cyhalothrin, lambda-cyhalothrin, and bifenthrin.

2. The residual spraying insecticide composition according to claim 1, characterized in that: In the composition, When component A is 4-trifluoromethylnicotinamide and component B is chlorfluazuron, the weight ratio of component A to component B is 5:1 to 1:

1. When component A is 4-trifluoromethylnicotinamide and component B is cis-cypermethrin, the weight ratio of component A to component B is 3:1 to 1:

5. When component A is 4-trifluoromethylnicotinamide and component B is high-efficiency cypermethrin, the weight ratio of component A to component B is 3:1 to 1:

3. When component A is 4-trifluoromethylnicotinamide and component B is lambda-cyhalothrin, the weight ratio of component A to component B is 3:1 to 1:

2. When component A is 4-trifluoromethylnicotinamide and component B is high-efficiency cypermethrin, the weight ratio of component A to component B is 5:1 to 1:

5. When component A is 4-trifluoromethylnicotinamide and component B is bifenthrin, the weight ratio of component A to component B is 3:1 to 1:

4.

3. A residual spray insecticide, characterized in that: The formulation comprises the composition of claim 1.

4. The residual spraying insecticide according to claim 3, characterized in that: The formulation is a wettable powder, a water-dispersible granule, or a suspension.

5. The residual spraying insecticide according to claim 3 or 4, characterized in that: When the formulation is a wettable powder, it comprises, by weight percentage: 5% to 30% of the composition of claim 1, 1% to 10% of the dispersant, 1% to 5% of the wetting agent, and filler, to a total of 100%.

6. The residual spraying insecticide according to claim 3 or 4, characterized in that: The formulation is a water-dispersible granule, comprising, by weight percentage: 10% to 50% of the composition of claim 1, 1% to 10% of a dispersant, 1% to 5% of a wetting agent, 1% to 10% of a disintegrant, 0.1% to 1% of a binder, and filler to make up to 100%.

7. The residual spraying insecticide according to claim 3 or 4, characterized in that: When the formulation is a suspension, it comprises, by weight percentage: 5%–30% of the composition of claim 1, 1%–10% of a dispersant, 1%–5% of a wetting agent, 0.1%–1% of a thickener, 0.1%–1% of a preservative, 3%–10% of an antifreeze, 0.1%–0.5% of an antifoamer, and deionized water to bring the total to 100%.

8. The application of the residual spray insecticide composition according to claim 1, characterized in that: Application of the composition in the prevention and control of public health pests.

9. The application of the residual spraying insecticide composition according to claim 8, characterized in that: The public health pests mentioned refer to one or more of the following: mosquitoes, flies, cockroaches, and fleas.

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