pH adjustor for solvent of mobile phase, solution for mobile phase, kit for liquid chromatography-mass spectrometry analysis, and analysis method for analysis sample
By using primary amines with suitable acid dissociation constants and boiling points as pH adjusters in the LC-MS analyzer, the problems of ammonia volatilization and high proton affinity of ethylamine were solved, achieving high-sensitivity long-term analysis results.
Patent Information
- Application Number
- CN202480068823.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2023-11-22
- Filing Date
- 2024-08-27
- Publication Date
- 2026-05-29
AI Technical Summary
When existing ammonia, alkali metal hydroxides, and ethylamine are used as pH adjusters in LC-MS analyzers, there are problems such as ammonia volatilization leading to reduced detection sensitivity, alkali metal hydroxide precipitation rendering them unusable, and ethylamine's high proton affinity leading to reduced detection sensitivity in positive ion mode.
Primary amines are used as pH adjusters, including compounds with an acid dissociation constant of 8.5 or higher, a proton affinity of 930 kJ/mol or lower, and a boiling point of 45°C or higher and 200°C or lower, such as cyclopropylamine and 2-methoxyethylamine, to adjust the pH of the mobile phase to make it alkaline.
The detection sensitivity of the LC-MS analyzer has been improved, making it suitable for long-term continuous analysis. It avoids the problems of ammonia volatilization and precipitation, and reduces the loss of detection sensitivity in positive ion mode.
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