Gel zinc ion battery medical transparent dressing, preparation method and application

Abstract

The present application relates to the technical field of medical dressings, in particular to a gel zinc ion battery medical transparent dressing, a preparation method and application. The gel zinc ion battery medical transparent dressing is obtained through the synergistic effect of acetonitrile porosity and natural polymer network compounding, a porous structure suitable for ion transmission is obtained, and high permeability is achieved. When the gel zinc ion battery is discharged, micro-current is continuously generated, and electric stimulation is generated on the wound tissue. At the same time, the discharge process consumes H + in the hydrogel electrolyte, further promotes the slow dissolution of nano calcium phosphate in the hydrogel electrolyte, continuously releases Ca 2+ , and supplements extracellular Ca 2+ . The intracellular Ca 2+ signal formed by the activation of Zn 2+ forms a synergy, further accelerates the migration and proliferation of epithelial cells, and has good repair effect.

Description

Technical Field

[0001] This invention relates to the field of medical dressing technology, and in particular to a gel zinc ion battery medical transparent dressing, its preparation method, and its application. Background Technology

[0002] Wound healing is a complex biological process involving four overlapping stages: hemostasis, inflammation, proliferation, and remodeling. In clinical practice, the treatment of chronic wounds, such as diabetic foot ulcers, pressure ulcers, and venous ulcers, remains a significant challenge, causing not only pain for patients but also a heavy medical burden. Traditional wound dressings mainly include gauze, hydrocolloid dressings, and alginate dressings, whose primary functions are to cover the wound, absorb exudate, and maintain a moist environment. However, their effects are relatively passive, lacking the ability to actively promote healing.

[0003] In recent years, electrostimulation therapy has been proven to effectively promote wound healing. Studies have shown that exogenous electric fields can guide the directional migration of keratinocytes and fibroblasts, promote cell proliferation and angiogenesis, and regulate inflammatory responses. Based on this, various electroactive dressings and wearable electrostimulation devices have been developed. For example, Chinese patent CN114195935A discloses a polyanionic zinc salt gel electrolyte and a zinc battery system. This electrolyte is an organic acid zinc salt polymer, prepared by polymerization of organic monomers, zinc salts, crosslinking agents, and initiators, thereby improving the electrochemical performance and cycle stability of the zinc battery system. For example, Chinese patent CN120381549A discloses a wearable magnesium battery self-powered dressing for chronic wound healing, its preparation method, and its application. It uses a flexible conductive carbon cloth coated with viologen-based covalent organic framework material as the positive electrode of the battery, a magnesium sheet as the negative electrode, and polyacrylamide hydrogel as the solid electrolyte to assemble a flexible wearable self-powered dressing. The formed electrode can effectively input electrical stimulation to the wound. However, the above-mentioned technical solutions can usually only focus on electrical stimulation and only provide physical electrical signals. The treatment mechanism is singular and the effect on chronic wounds with microenvironmental imbalance is limited.

[0004] A series of studies by Peter M. Elias and Theodora M. Mauro's team at the Department of Dermatology, Northwestern University, systematically elucidated the role of calcium ion gradients as "first messengers" in epidermal barrier repair and wound healing. The authoritative Chinese journal *Chinese Journal of Trauma and Repair* has published reviews such as "The Role of Calcium Ions in Skin Wound Healing," which systematically summarize the role of calcium ions in wound healing. 2+ The text discusses the functions of Zn in various stages of wound healing and explicitly states that "topical application of calcium may promote wound repair." It also mentions that Zn is not currently being used in this context. 2+ Battery discharge and Ca 2+ Research on the release of combined and synergistic therapies.

[0005] Therefore, the inventor proposed a method to use Zn 2+ Physical electrical stimulation of battery discharge and controlled release of Ca 2+ A medical transparent dressing combining chemobiological signal therapy with a gel zinc-ion battery, its preparation method, and its application. The dressing intelligently triggers the release of Ca from nano-calcium phosphate through changes in the local microenvironment induced by battery operation. 2+ To precisely replenish the wound's needs. Summary of the Invention

[0006] The purpose of this invention is to provide a transparent medical dressing for gel zinc-ion batteries, its preparation method, and its application, in order to solve the problems mentioned in the background art. The specific technical solution is as follows:

[0007] To achieve the above and other related objectives, the first objective of this invention is to provide a method for preparing a gel-based transparent medical dressing for zinc-ion batteries, comprising:

[0008] S1. Preparation of hydrogel electrolyte precursor solution: Dissolve acrylamide monomer in a mixed solvent of acetonitrile and water, add silk fibroin, sodium alginate, pH buffer and nano-sized calcium phosphate, mix well to obtain precursor solution;

[0009] S2. Polymerization to form hydrogel: Initiator and crosslinking agent are added to the precursor solution, and the mixture is injected into a mold to carry out the polymerization reaction to obtain hydrogel;

[0010] S3, Electrolyte loading: The hydrogel obtained in step S2 is immersed in an electrolyte solution containing zinc ions and calcium ions to obtain a hydrogel electrolyte;

[0011] S4. Battery assembly: Cut the hydrogel electrolyte obtained in step S3 into a predetermined shape and size, place the zinc negative electrode in the peripheral area of ​​one side of the hydrogel electrolyte, and place the positive electrode in the central area of ​​the other side of the hydrogel electrolyte to obtain the medical transparent dressing for the gel zinc ion battery.

[0012] Preferably, the volume ratio of acetonitrile to water in step S1 is 1:4.

[0013] Preferably, the pH buffer pair in step S1 is histidine and histidine hydrochloride, with a buffer pH of 6.0-7.5.

[0014] Preferably, the particle size of the nano-sized calcium phosphate in step S1 is less than 50 nm.

[0015] Preferably, the polymerization reaction temperature in step S2 is 50-70°C and the time is 1-3 hours.

[0016] Preferably, the electrolyte solution in step S3 is a mixed solution containing 2 mol / L ZnSO4 and 0.1 mol / L CaCl2.

[0017] Preferably, in step S4, the zinc negative electrode is a fan-shaped zinc foil connected to a conductive ring via a guide wire, the conductive ring being arranged in the peripheral area of ​​the hydrogel electrolyte, and the positive electrode is an iodine activated carbon composite material.

[0018] A second objective of this invention is to provide a gel-based transparent medical dressing for zinc-ion batteries prepared according to any of the above-described preparation methods, comprising:

[0019] A hydrogel electrolyte comprising a polymer matrix, zinc ions, and a calcium ion source, wherein the calcium ion source is capable of releasing calcium ions in response to local pH changes during battery discharge;

[0020] The negative electrode, comprising a zinc material, is configured to adhere to the periphery of the wound and to be in electrical contact with the hydrogel electrolyte;

[0021] A positive electrode, comprising a positive electrode active material, is disposed on the side of the hydrogel electrolyte opposite to the wound;

[0022] The battery generates a microcurrent to apply electrical stimulation to the wound during discharge, while the negative electrode dissolves to generate zinc ions, and the calcium ion source releases calcium ions in response to the local pH increase caused by discharge.

[0023] Preferably, the negative electrode is connected to a conductive ring via a guide wire, and the conductive ring is arranged on the lower side of the hydrogel electrolyte; the positive electrode is an iodine activated carbon composite material, which is connected to the upper center of the hydrogel electrolyte via a guide wire; a transparent observation window is reserved in the center of the hydrogel electrolyte.

[0024] A third objective of this invention is to protect the use of the above-mentioned gel zinc-ion battery medical transparent dressing in the preparation of medical devices for promoting wound healing.

[0025] The following are beneficial effects:

[0026] This invention achieves a porous structure suitable for ion transport through the synergistic effect of acetonitrile-induced pores and a natural polymer network, exhibiting high permeability. During discharge, the gel zinc-ion battery continuously generates microcurrents, providing electrical stimulation to wound tissue and releasing extremely low concentrations of Zn. 2+ It activates ZnR / GPR39 receptors on wound epidermal cells, triggering the release of Ca from intracellular calcium stores. 2+ It activates repair signaling pathways, accelerates wound healing, and at the same time, the discharge process consumes H+ in the hydrogel electrolyte. +This causes a slight increase in pH at the interface between the gel and the wound, further promoting the slow dissolution of the nano-calcium phosphate in the hydrogel electrolyte and continuously releasing Ca. 2+ extracellular Ca 2+ In addition, during the early stages of application, corresponding to the inflammatory phase of the wound, the pH is low and the calcium content is high. 2+ Release is slow; during the proliferative phase of cell repair, pH rises slightly, and Ca... 2+ Release acceleration, with Zn 2+ Intracellular Ca2+ generated by activation 2+ The synergistic signal formation perfectly matches the period when cells have the greatest demand for calcium signals, further accelerating epithelial cell migration and proliferation, and exhibiting a good repair effect. Attached Figure Description

[0027] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0028] Figure 1 This is an optical photograph of the hydrogel electrolyte prepared in Example 1;

[0029] Figure 2 This is a photograph of the I2@AC||Zn zinc ion battery assembled with gel electrolyte in Example 1;

[0030] Figure 3 These are the results of the rat model healing experiment in Examples 1-3;

[0031] Figure 4 This is a graph showing the tensile strength and toughness test results of Example 1;

[0032] Figure 5 The ionic conductivity of the hydrogel electrolytes prepared in Examples 1 and 4;

[0033] Figure 6 These are the time-voltage curves of Zn||Zn symmetric cells assembled with hydrogel electrolytes prepared in Examples 1 and 4;

[0034] Figure 7 The image shows the capacity-voltage curve of the I2@AC||Zn ion battery prepared in Example 1. Detailed Implementation

[0035] The following detailed description, in conjunction with the accompanying drawings and specific embodiments, provides a further detailed explanation of the gel-based zinc-ion battery medical transparent dressing, its preparation method, and its application. The advantages and features of the present invention will become clearer from the following description. It should be noted that the accompanying drawings are all in a very simplified form and use non-precise proportions, and are only used to facilitate and clarify the illustration of the embodiments of the present invention.

[0036] In the description of this invention, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0037] It should be noted that the illustrations provided in the following embodiments are only schematic representations of the basic concept of the present invention. Therefore, the illustrations only show the components related to the present invention and are not drawn according to the actual number, shape and size of the components in the actual implementation. In the actual implementation, the state, quantity and proportion of each component can be arbitrarily changed, and the layout of the components may also be more complex.

[0038] Example 1

[0039] Preparation of a transparent medical dressing made from gel zinc-ion batteries for wound dressing:

[0040] 1. Preparation of hydrogel electrolytes:

[0041] Take 8 mL of deionized water and place it in a beaker. Add 2 mL of acetonitrile and stir until well mixed. Weigh 2 g of acrylamide monomer and add it to the above mixture, stirring until completely dissolved. Add 0.1 g of silk fibroin powder and 0.05 g of sodium alginate, stirring until evenly dispersed. The carboxyl groups of sodium alginate can provide additional zinc ion transport channels. Add 0.15 g of histidine and 0.10 g of histidine hydrochloride to form a pH buffer pair with a buffer zone of approximately pH 6.0-7.5, closely resembling the wound microenvironment. Add 0.02 g of nano-sized calcium phosphate as a calcium ion reservoir. Add 100 μL of pre-prepared 0.01% ammonium persulfate solution and 0.1% N,N'-methylenebisacrylamide solution, respectively. After stirring, pour into a mold and polymerize at 60 °C for 2 hours to form a hydrogel. Completely immerse the hydrogel in a mixed solution of 2 mol / L ZnSO4 and 0.1 mol / L CaCl2 and let it stand for 24 hours to obtain the hydrogel electrolyte. Figure 1 As shown, the prepared hydrogel electrolyte is transparent, pure, and has good light transmittance;

[0042] 2. Assembly of gel zinc ion battery medical transparent dressing:

[0043] like Figure 2 As shown, the hydrogel is cut into circular pieces with a diameter of 20 mm and a thickness of 1 mm. The cut hydrogel electrolyte replaces the diaphragm and electrolyte. Negative electrode: A fan-shaped zinc foil with a diameter of 20 mm is used as the negative electrode. The negative electrode is connected to a conductive ring through a guide wire. The conductive ring is arranged on the lower side of the hydrogel electrolyte and adheres to the outer periphery of the wound without direct contact with the wound. Positive electrode: An iodine activated carbon composite material is used as the positive electrode. The positive electrode is connected to the upper center of the hydrogel electrolyte through a guide wire. A transparent gel I2@AC||Zn ion battery for wound dressing is completed, thus reserving a transparent observation window in the center of the hydrogel electrolyte to facilitate observation of the wound healing process.

[0044] The working principle is as follows:

[0045] When the gel I2@AC||Zn ion battery discharges, it generates a continuous direct current, which electrically stimulates the wound tissue; furthermore, during the discharge process, the zinc anode dissolves to produce nanomolar concentrations of Zn. 2+ This concentration can activate ZnR / GPR39 receptors on wound epidermal cells, triggering the release of Ca from intracellular calcium stores. 2+ It activates the repair signaling pathway, and at the same time, the discharge process consumes H in the hydrogel electrolyte. + This causes a slight increase in pH at the interface between the gel and the wound. This environmental change prompts the slow dissolution of the nano-calcium phosphate in the hydrogel, continuously releasing Ca. 2+ extracellular Ca 2+ The supplement, with Zn 2+ Intracellular Ca2+ generated by activation 2+ The synergistic signaling further accelerates epithelial cell migration and proliferation. The histidine buffer system is designed to help maintain a relatively stable weakly acidic environment at the wound interface, which is more conducive to healing.

[0046] Example 2

[0047] Preparation of a transparent medical dressing made from gel zinc-ion batteries for wound dressing:

[0048] 1. Preparation of hydrogel electrolytes:

[0049] Take 8 mL of deionized water and place it in a beaker. Add 2 mL of acetonitrile and stir until well mixed. Weigh 2 g of acrylamide monomer and add it to the above mixture. Stir until completely dissolved. Add 0.1 g of silk fibroin powder and 0.05 g of sodium alginate and stir until evenly dispersed. The carboxyl groups of sodium alginate can provide additional zinc ion transport channels. Add 0.15 g of histidine and 0.10 g of histidine hydrochloride to form a pH buffer pair. The buffer zone is approximately pH 6.0-7.5, which is close to the wound microenvironment. Add 100 μL of pre-prepared 0.01% ammonium persulfate solution and 0.1% N,N'-methylenebisacrylamide solution respectively. After stirring, pour into a mold and polymerize at 60 °C for 2 hours to form a hydrogel. Completely immerse the hydrogel in a 2 mol / L ZnSO4 mixed solution and let it stand for 24 hours to obtain the hydrogel electrolyte. The prepared hydrogel electrolyte is transparent, pure, and has good light transmittance.

[0050] 2. Assembly of gel zinc ion battery medical transparent dressing:

[0051] The hydrogel was cut into circular pieces with a diameter of 20 mm and a thickness of 1 mm. The cut hydrogel electrolyte replaced the diaphragm and electrolyte. The negative electrode was a fan-shaped zinc foil with a diameter of 20 mm. The negative electrode was connected to a conductive ring through a guide wire. The conductive ring was arranged on the lower side of the hydrogel electrolyte and attached to the outer periphery of the wound without direct contact with the wound. The positive electrode was an iodine activated carbon composite material. The positive electrode was connected to the upper center of the hydrogel electrolyte through a guide wire. A transparent gel I2@AC||Zn ion battery for wound dressing was completed, thus leaving a transparent observation window in the center of the hydrogel electrolyte to facilitate the observation of wound healing.

[0052] Example 3

[0053] Take 8 mL of deionized water and place it in a beaker. Add 2 mL of acetonitrile and stir until well mixed. Weigh 2 g of acrylamide monomer and add it to the above mixture. Stir until completely dissolved. Add 0.1 g of silk fibroin powder and 0.05 g of sodium alginate and stir until evenly dispersed. The carboxyl groups of sodium alginate can provide additional zinc ion transport channels. Add 0.15 g of histidine and 0.10 g of histidine hydrochloride to form a pH buffer pair. The buffer zone is approximately pH 6.0-7.5, which is close to the wound microenvironment. Add 0.02 g of nano-sized calcium phosphate as a calcium ion reservoir. Add 100 μL of pre-prepared 0.01% ammonium persulfate solution and 0.1% N,N'-methylenebisacrylamide solution respectively. After stirring, pour into a mold and polymerize at 60 °C for 2 hours to form a hydrogel. Completely immerse the hydrogel in a 0.1 mol / L CaCl2 mixed solution and let it stand for 24 hours. Cut the obtained hydrogel into round pieces with a diameter of 20 mm and a thickness of 1 mm. Do not assemble them into batteries.

[0054] Example 4

[0055] The difference from Comparative Document 1 is that deionized water is used instead of acetonitrile.

[0056] In this embodiment, a healing experiment was conducted to verify the healing effect. A rat model was constructed using male SD rats, aged 8 weeks. A full-thickness skin defect with a diameter of 10 mm was prepared. The wound area was recorded daily by taking photos at regular intervals. Comparative Example 1 used ordinary PAM hydrogel for treatment. The results are as follows: Figure 3 As shown, Example 1 exhibited the best healing effect, with the wound essentially healed by day 10, thanks to the Zn... 2+ Electrical stimulation, Ca 2+ The synergistic effect of released chemical signals and potential microenvironment regulation, as can be seen by comparing Example 1 and Example 2, shows that the absence of Ca... 2+ The healing effect of the released Example 2 was worse than that of Example 1, indicating that Ca 2+ The release did indeed effectively promote healing. In the first three days, the difference in healing effects between Example 1 and Example 2 was not significant, indicating that the wound was in the inflammatory phase in the early stages, when the pH was low and the calcium content was high. 2+ Release is slow; from day 4 to 10, cell repair enters the cell proliferation phase, H + Consumed, pH rises slightly, Ca 2+ Release acceleration, with Zn 2+ Intracellular Ca2+ generated by activation 2+ The signal formation synergy perfectly matched the period when cells had the greatest demand for calcium signals; therefore, from the fourth day onwards, the healing speed of Example 1 significantly increased. A comparison of Comparative Example 1 and Example 3 showed that, compared to Comparative Example 1 using ordinary PAM hydrogel, the hydrogel in Example 3 treated with nano-sized calcium phosphate did not effectively promote wound healing, indicating that in the absence of an electric current, Ca... 2+ The release of Ca is not significant, or only a small amount is released. 2+ It has no obvious effect on wound healing.

[0057] This embodiment presents basic performance tests on the transparent gel I2@AC||Zn ion battery prepared in Example 1;

[0058] First, mechanical tensile strength and toughness tests were conducted, and the results are as follows: Figure 4 As shown, from Figure 4 As can be seen, the tensile strength of the transparent gel I2@AC||Zn ion battery prepared in Example 1 is significantly higher than that of ordinary PAM hydrogel. Figure 4 b. It can be seen that the transparent gel I2@AC||Zn ion battery prepared in Example 1 has significantly higher toughness than ordinary PAM hydrogel, with better mechanical properties and is not easily damaged.

[0059] The ionic conductivity of the hydrogel electrolytes prepared in Examples 1 and 4 was tested, and the results are as follows: Figure 5 As shown, the hydrogel electrolyte prepared in Example 1 achieved an ionic conductivity of 17.19 mS / cm, which is significantly better than the method in Example 4 that does not use acetonitrile. This is due to the acetonitrile-induced pores and the micronetwork constructed from silk fibroin / sodium alginate. The hydrogel has abundant hydrophilic channels, and this structure can efficiently adsorb and store electrolyte, significantly reducing ion migration resistance and providing Zn 2+ It provides a rapid transmission path, thereby significantly improving ionic conductivity. The high ionic conductivity effectively reduces the battery's internal resistance, enabling stable current output even under high-rate discharge conditions. The porous network gives the electrolyte excellent electrolyte retention capabilities, preventing localized drying even when the battery is repeatedly bent or operated for extended periods in a flexible wearable state, thus ensuring continuous and stable current output. This characteristic is particularly crucial for wound electrical stimulation therapy, ensuring that the microcurrent acts continuously and evenly on the wound surface, avoiding disruptions to the healing process due to current fluctuations or interruptions.

[0060] This embodiment also tests the time-voltage curves of Zn||Zn symmetric cells assembled with hydrogel electrolytes prepared in Examples 1 and 4, and the results are as follows: Figure 6 As shown, the Zn||Zn symmetric battery assembled in Example 4 exhibited significant voltage fluctuations and instability after several hundred hours, indicating severe side reactions or zinc dendrite growth within the battery, leading to rapid performance degradation. In contrast, the Zn||Zn symmetric battery assembled with the hydrogel electrolyte prepared in Example 1 showed a very stable voltage curve, with almost no significant fluctuations during testing exceeding 1200 hours, consistently remaining within a stable voltage range. This demonstrates that the modified electrolyte effectively suppresses zinc dendrite growth and side reactions, significantly improving the battery's cycle life and stability.

[0061] This embodiment also tested the capacity-voltage curve of the I2@AC||Zn ion battery prepared in Example 1, and the results are as follows: Figure 7 As shown, the capacity remained stable during 120 cycles without significant decay, indicating that the battery has high utilization of active materials and a stable structure. The coulombic efficiency fluctuated slightly in the early stage of the cycle, but quickly stabilized at a level close to 100% and remained stable throughout the 120 cycles. This shows that during the charging and discharging process, side reactions were effectively suppressed, the transfer efficiency of electrons and ions was extremely high, and energy loss was minimal.

[0062] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. A method for preparing a transparent medical dressing for gel zinc-ion batteries, characterized in that, include: S1. Preparation of hydrogel electrolyte precursor solution: Dissolve acrylamide monomer in a mixed solvent of acetonitrile and water, add silk fibroin, sodium alginate, pH buffer and nano-sized calcium phosphate, mix well to obtain precursor solution; S2. Polymerization to form hydrogel: Initiator and crosslinking agent are added to the precursor solution, and the mixture is injected into a mold to carry out the polymerization reaction to obtain hydrogel; S3, Electrolyte loading: The hydrogel obtained in step S2 is immersed in an electrolyte solution containing zinc ions and calcium ions to obtain a hydrogel electrolyte; S4. Battery assembly: Cut the hydrogel electrolyte obtained in step S3 into a predetermined shape and size, place the zinc negative electrode in the peripheral area of ​​one side of the hydrogel electrolyte, and place the positive electrode in the central area of ​​the other side of the hydrogel electrolyte to obtain the medical transparent dressing for the gel zinc ion battery.

2. The preparation method according to claim 1, characterized in that, The volume ratio of acetonitrile to water in step S1 is 1:

4.

3. The preparation method according to claim 1, characterized in that, The pH buffer pair mentioned in step S1 is histidine and histidine hydrochloride, with a buffer zone of pH 6.0-7.

5.

4. The preparation method according to claim 1, characterized in that, The particle size of the nano-sized calcium phosphate in step S1 is less than 50 nm.

5. The preparation method according to claim 1, characterized in that, The polymerization reaction in step S2 is carried out at a temperature of 50-70°C for 1-3 hours.

6. The preparation method according to claim 1, characterized in that, The electrolyte solution mentioned in step S3 is a mixed solution containing 2 mol / L ZnSO4 and 0.1 mol / L CaCl2.

7. The preparation method according to claim 1, characterized in that, In step S4, the zinc negative electrode is a fan-shaped zinc foil connected to a conductive ring via a guide wire. The conductive ring is arranged in the peripheral area of ​​the hydrogel electrolyte, and the positive electrode is an iodine activated carbon composite material.

8. A transparent medical dressing for zinc-ion batteries prepared by the preparation method according to any one of claims 1-7, characterized in that, include: A hydrogel electrolyte comprising a polymer matrix, zinc ions, and a calcium ion source, wherein the calcium ion source is capable of releasing calcium ions in response to local pH changes during battery discharge; The negative electrode, comprising a zinc material, is configured to adhere to the periphery of the wound and to be in electrical contact with the hydrogel electrolyte; A positive electrode, comprising a positive electrode active material, is disposed on the side of the hydrogel electrolyte opposite to the wound; The battery generates a microcurrent to apply electrical stimulation to the wound during discharge, while the negative electrode dissolves to generate zinc ions, and the calcium ion source releases calcium ions in response to the local pH increase caused by discharge.

9. The gel-based transparent medical dressing for zinc-ion batteries according to claim 8, characterized in that, The negative electrode is connected to a conductive ring via a guide wire, and the conductive ring is arranged on the lower side of the hydrogel electrolyte; the positive electrode is made of iodine activated carbon composite material, and the positive electrode is connected to the upper center of the hydrogel electrolyte via a guide wire; a transparent observation window is reserved in the center of the hydrogel electrolyte.

10. The use of the gel zinc-ion battery medical transparent dressing according to any one of claims 8-9 in the preparation of a medical device for promoting wound healing.

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