Reaction control device of centrifugal micro-fluidic chip

By integrating the chip support, drive module, heating and temperature control module, fluorescence detection module and magnetic bead control module for coordinated control, the problems of high complexity, low heating efficiency and high risk of contamination in existing centrifugal microfluidic systems are solved, realizing efficient, automated and precise in vitro diagnostics.

CN122273601APending Publication Date: 2026-06-26SHENZHEN YILIFANG BIOTECH CO LTD
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Patent Information

Application Number
CN202610173429.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-06
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Existing centrifugal microfluidic systems suffer from problems such as high complexity of the drive system, low heating efficiency, difficulty in achieving multi-zone temperature control, and high risk of aerosol contamination and leakage, making it difficult to meet the needs of efficient, automated, and precise in vitro diagnostics.

Method used

By integrating a chip holder, drive module, heating and temperature control module, fluorescence detection module, and magnetic bead control module, the entire process of centrifugal microfluidic chip operation is automated, simplifying speed control, providing precise temperature control and magnetic bead control, and ensuring accurate alignment of the detection optical path.

Benefits of technology

It achieves fully automated operation of centrifugal microfluidic chips, improving reaction efficiency and detection accuracy, reducing contamination risks and costs, and is suitable for clinical diagnosis and food safety testing.

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Abstract

The invention discloses a reaction control device of a centrifugal micro-fluidic chip, and relates to the technical field of in vitro diagnosis, the reaction control device comprises a chip support used for installing the centrifugal micro-fluidic chip, and the centrifugal micro-fluidic chip can contain a sample to be detected; the driving module is connected with the chip bracket and can drive the chip bracket to rotate; the heating temperature control module is connected with the chip bracket or is arranged on one side of the chip bracket and can be used for controlling the temperature of the centrifugal micro-fluidic chip on the chip bracket; the fluorescence detection module is arranged below the chip bracket, the fluorescence detection module is used for detecting the reaction condition of the sample to be detected, and a fluorescence detection hole matched with the fluorescence detection module is formed in the chip bracket; and the magnetic bead control module is matched with the heating temperature control module and is used for assisting the treatment of the sample to be detected. According to the application, through organic integration and cooperative control of multiple modules, integrated operation of the centrifugal micro-fluidic chip from sample treatment, reaction control to result detection is realized.
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