Copper nanoparticle-based SERS sensor, its preparation method, and its application in detecting trace amounts of doxorubicin.

By self-assembling metal halide-oxide nanosheets on a porous anodic alumina substrate and depositing copper nanoparticles using atomic layer deposition, a high-density, uniformly distributed three-dimensional structure is formed, solving the problems of high cost of noble metal substrates and poor controllability of copper-based substrates, and realizing low-cost, high-sensitivity SERS detection of doxorubicin.

CN122306779APending Publication Date: 2026-06-30NORTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NORTHWEST UNIV
Filing Date
2026-04-16
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing SERS sensors based on precious metal substrates are costly and have poor biocompatibility. Copper-based SERS substrates have insufficient controllability of nanostructure and specific surface area, resulting in low sensitivity for doxorubicin detection. Existing copper-based SERS sensors mainly rely on fluorescence technology rather than SERS.

Method used

We employ self-assembled metal halide-oxide nanosheets on a porous anodic alumina substrate, and deposit copper nanoparticles on them using atomic layer deposition to form a high-density, uniformly distributed three-dimensional structure, thereby enhancing SERS hotspots.

Benefits of technology

It achieves low-cost, high-sensitivity detection of doxorubicin with a detection limit as low as 0.5 ppm, suitable for monitoring clinical therapeutic drugs and detecting trace doxorubicin residues in environmental water samples, and has good signal reproducibility.

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Abstract

This invention discloses a copper nanoparticle-based SERS sensor, its preparation method, and its application in trace detection of doxorubicin. The sensor comprises a porous anodic alumina substrate, metal halide-oxide nanosheets vertically grown on its surface, and copper nanoparticles uniformly deposited on the surface and sidewalls of the nanosheets via atomic layer deposition (ALD). The preparation method involves first preparing the porous anodic alumina substrate via anodic oxidation, then self-assembling and growing the metal halide-oxide nanosheets, and finally using copper hexafluoroacetylacetone as a copper precursor and diethylzinc as a reducing agent, employing ALD to precisely control the particle size and distribution of the copper nanoparticles. This sensor is used for trace doxorubicin detection, with a detection limit as low as 0.5 ppm, covering the clinical therapeutic drug monitoring concentration range. It has the advantages of low cost, high sensitivity, and controllable structure. This invention provides a low-cost, high-sensitivity, structurally controllable, and highly consistent SERS sensor for trace doxorubicin detection.
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