A repair composition, its use and a repair serum and a method for the preparation thereof

Abstract

The application provides a repairing composition and application thereof and a repairing essence and a preparation method thereof, and relates to the technical field of skin care products. The repairing composition comprises the following components in mass fractions: panthenol 5-15 parts, diethoxy ethyl succinate 0.5-3 parts, hydrolyzed red algae extract 0.1-3 parts, and papain 0.01-0.1 part. The repairing composition is used in skin care products such as essence, can improve the sticky feeling caused by high content panthenol (5-15%), at the same time, can enhance the absorption performance of panthenol, and better skin repairing effect can be obtained. The application provides a repairing essence, which comprises the following components in mass percentages: the repairing composition 5.61-21.1%, alcohol solvent 5-15%, preservative 0.5-2%, and water in the rest. The repairing essence provided by the application has good skin feeling, transdermal absorption performance and soothing and repairing effect.

Description

Technical Field

[0001] This invention relates to the field of skincare technology, and more particularly to a repair composition and its application, and a repair serum and its preparation method. Background Technology

[0002] Panthenol, commonly known as provitamin B5 or D-panthenol, is the alcohol form of vitamin B5 (pantothenic acid). It is widely used in skincare, haircare, and pharmaceuticals, and is highly favored for its excellent moisturizing, repairing, and soothing effects. Its specific uses include: powerful moisturizing and water-locking, repairing the skin barrier; possessing anti-inflammatory properties, effectively soothing skin irritation, redness, itching, and discomfort, often used to relieve minor burns, sunburn, eczema, diaper rash, and other skin problems, and also suitable for daily care of sensitive skin; in pharmaceuticals and high-end skincare products, panthenol is used to promote the healing of cuts, abrasions, and post-operative wounds, reducing scar formation; relieving various sensitivity symptoms caused by barrier damage; and is one of the recommended repair ingredients after laser, microneedling, and other medical aesthetic procedures. Furthermore, panthenol is very safe, exhibiting excellent repair effects at concentrations of 2-5%, with higher concentrations (5-15%) showing even more pronounced effects.

[0003] However, products with high panthenol content, such as some serums (panthenol content 5~15%), have a thicker texture, which is uncomfortable to use and brings a noticeable sticky feeling. Summary of the Invention

[0004] In view of this, the purpose of this invention is to provide a repair composition and its application, as well as a repair serum and its preparation method. The repair composition provided by this invention, when used in skin care products such as serums, can significantly improve the stickiness caused by high panthenol content (panthenol content 5-15%).

[0005] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a repair composition comprising the following components in parts by weight: Panthenol 5-15 parts, diethoxyethyl succinate 0.5-3 parts, hydrolyzed red algae extract 0.1-3 parts, papain 0.01-0.1 parts.

[0006] Preferably, the repair composition comprises the following components in parts by weight: Panthenol 10-13 parts, diethoxyethyl succinate 1-3 parts, hydrolyzed red algae extract 1-3 parts, papain 0.05-0.1 parts.

[0007] This invention provides the application of the repair composition described above in skin care products.

[0008] Preferably, the skincare product includes a serum.

[0009] This invention provides a repairing serum comprising the following components in weight percentage: The repair composition comprises 5.61-21.1% alcohol solvent, 5-15% preservative, 0.5-2% water, and the balance being water; the repair composition is the repair composition described in the above technical solution.

[0010] Preferably, the alcohol solvent includes one or more of 1,3-propanediol, glycerol, and 1,3-butanediol, and the preservative includes 1,2-hexanediol and p-hydroxyacetophenone, wherein the mass ratio of 1,2-hexanediol to p-hydroxyacetophenone is 1:1.

[0011] This invention provides a method for preparing the repair essence described in the above technical solution, comprising the following steps: Panthenol and diethoxyethyl succinate in the repair composition are first mixed to obtain a first mixture; the temperature of the first mixing is 65~75°C. The first mixture is then mixed with an alcohol solvent and a preservative to obtain a second mixture; The second mixture is then mixed with water to obtain a third mixture; The third mixture is then mixed with the papain and hydrolyzed red algae extract in the repair composition to obtain the repair essence.

[0012] Preferably, the first mixing is carried out under stirring and homogenization conditions, wherein the stirring rate is 35-45 rpm, the homogenization rate is 700-1500 rpm, and the first mixing time is 4-7 minutes.

[0013] Preferably, the second mixing method is as follows: dissolving the alcohol solvent and the preservative under heating conditions, and adding the dissolved mixture to the first mixture for mixing; the heating temperature is 65~75℃.

[0014] Preferably, when the papain and hydrolyzed red algae extract in the repair composition are mixed for the fourth time, the temperature of the third mixture is 30-40°C.

[0015] This invention provides a repair composition comprising the following components in parts by weight: 5-15 parts panthenol, 0.5-3 parts diethoxyethyl succinate, 0.1-3 parts hydrolyzed red algae extract, and 0.01-0.1 parts papain. In this invention, the addition of diethoxyethyl succinate to the repair composition allows the hydroxyl groups of panthenol to "insert" into the molecular structure of diethoxyethyl succinate, forming a supramolecular complex. This complex combines the advantages of both components while reducing the stickiness of panthenol. Diethoxyethyl succinate has a water solubility of approximately 3%, and when combined with the hydrolyzed red algae extract, it forms a hydrophilic and lipophilic film on the skin surface, providing a silky feel and further reducing stickiness. Furthermore, the addition of the hydrolyzed red algae extract stabilizes the complex structure of panthenol and diethoxyethyl succinate. Papain softens the stratum corneum, promotes transdermal absorption of panthenol, shortens the time panthenol remains on the skin surface, enhances the repair effect, and reduces stickiness. When the repair composition provided by this invention is used in skin care products such as serums, it can improve the stickiness caused by high panthenol content (panthenol content 5~15%), while enhancing the absorption performance of panthenol and obtaining better skin repair effects.

[0016] This invention provides a repairing serum comprising the following components by weight percentage: 5.61-21.1% repairing composition, 5-15% alcohol solvent, 0.5-2% preservative, and the balance being water; wherein the repairing composition is the same as described in the above technical solution. The repairing serum provided by this invention (panthenol content 5-15%) simultaneously possesses excellent skin feel, transdermal absorption performance, and soothing and repairing effects. Detailed Implementation

[0017] This invention provides a repair composition comprising the following components in parts by weight: Panthenol 5-15 parts, diethoxyethyl succinate 0.5-3 parts, hydrolyzed red algae extract 0.1-3 parts, papain 0.01-0.1 parts.

[0018] Unless otherwise specified, all components / equipment involved in this invention are commercially available products well known in the art.

[0019] The repair composition provided by the present invention comprises 5 to 15 parts of panthenol, which can be 6, 8, 10, 11, 12, 13, 14 or 15 parts by weight.

[0020] Based on the mass fraction of panthenol, the repair composition provided by this invention includes 0.5 to 3 parts of diethoxyethyl succinate, which can be 0.5, 1, 2, or 3 parts. Panthenol molecules are rich in hydroxyl groups, which readily form hydrogen bonds with water, producing a sticky feel. Diethoxyethyl succinate and panthenol can form a complex structure, which not only combines the advantages of both panthenol and diethoxyethyl succinate, but also significantly reduces the stickiness of panthenol and improves its penetration and absorption efficiency. Furthermore, the addition of the hydrolyzed red algae extract can further promote the above effects.

[0021] Based on the mass fraction of panthenol, the repair composition provided by this invention comprises 0.1 to 3 parts of hydrolyzed red algae extract, which can be 0.1, 1, 2, or 3 parts. In the embodiments of this invention, the hydrolyzed red algae extract was purchased from Chemisches Laboratorium Dr. Kurt Richter GmbH (CLR), under the trade name CutiGuard CLR. TM Diethoxyethyl succinate has a solubility of approximately 3% in water. When combined with hydrolyzed red algae extract, it can form a hydrophilic and lipophilic film on the skin surface, providing a silky feel and further reducing stickiness. At the same time, as a film-forming agent, the hydrolyzed red algae extract can enhance the stability of the supramolecular complex formed by panthenol and diethoxyethyl succinate.

[0022] Based on the mass fraction of panthenol, the repair composition provided by this invention includes 0.01 to 0.1 parts of papain, which can be 0.01, 0.05, or 0.1 parts. This invention does not have any particular requirements for the papain used; any papain well-known to those skilled in the art can be used. In the embodiments of this invention, the papain was purchased from Zhengzhou Kema Biotechnology Co., Ltd., under the trade name PROTESSE G66. In this invention, the papain can soften the stratum corneum, promote the transdermal absorption of active ingredients such as panthenol, shorten the time panthenol remains on the skin surface, enhance the repair effect, and reduce stickiness.

[0023] This invention provides the application of the repair composition described above in skin care products.

[0024] In this invention, the skin care product preferably includes a serum.

[0025] When the repair composition provided by this invention is used in skin care products such as serums, it can improve the stickiness caused by high panthenol content (panthenol content 5~15%), while enhancing the absorption performance of panthenol and obtaining better skin repair effects.

[0026] This invention provides a repairing serum comprising the following components in weight percentage: The repair composition comprises 5.61-21.1% alcohol solvent, 5-15% preservative, 0.5-2% water, and the balance being water; the repair composition is the repair composition described in the above technical solution.

[0027] The repair essence provided by this invention comprises 5.61-21.1% (by weight), specifically 10.61%, 13.05%, 14.05%, or 16.1% of a repair composition. In this invention, the repair essence specifically comprises 5-15% panthenol (which may be 6%, 8%, 10%, 11%, 12%, 13%, 14%, or 15%), 0.5-3% diethoxyethyl succinate (which may be 0.5%, 1%, 2%, or 3%), 0.1-3% hydrolyzed red algae extract (which may be 0.1%, 1%, 2%, or 3%), and 0.01-0.1% papain (which may be 0.01%, 0.05%, or 0.1%).

[0028] The repairing essence provided by this invention comprises 5-15% alcohol solvent, which can be 5% or 10%, by weight percentage. In this invention, the alcohol solvent preferably includes one or more of 1,3-propanediol, glycerin, and 1,3-butanediol; the alcohol solvent also serves as a stabilizer and a preservative synergist.

[0029] The repair essence provided by the present invention comprises 0.5-2% preservatives by weight percentage, and can be 1%. In the present invention, the preservatives preferably include 1,2-hexanediol and p-hydroxyacetophenone, and the mass ratio of 1,2-hexanediol and p-hydroxyacetophenone is preferably 1:1.

[0030] The repair essence provided by this invention comprises water as a percentage by weight. This invention does not have any particular requirements for the water.

[0031] The repair essence provided by this invention has good skin feel, transdermal absorption performance, and soothing and repairing effects.

[0032] This invention provides a method for preparing the repair essence described in the above technical solution, comprising the following steps: Panthenol and diethoxyethyl succinate in the repair composition are first mixed to obtain a first mixture; the temperature of the first mixing is 65~75°C. The first mixture is then mixed with an alcohol solvent and a preservative to obtain a second mixture; The second mixture is then mixed with water to obtain a third mixture; The third mixture is then mixed with the papain and hydrolyzed red algae extract in the repair composition to obtain the repair essence.

[0033] In this invention, panthenol and diethoxyethyl succinate in the repair composition are first mixed to obtain a first mixture.

[0034] In this invention, the temperature of the first mixing is 65-75°C, which can be 70°C. The first mixing is preferably carried out under stirring and homogenization conditions. The stirring rate is preferably 35-45 rpm, which can be 40 rpm. The homogenization rate is preferably 700-1500 rpm, which can be 1000 rpm. The first mixing time is preferably 4-7 minutes, which can be 5 minutes. The first mixing is preferably carried out in an emulsifying tank. Specifically, panthenol and diethoxyethyl succinate from the repair composition are added to the emulsifying tank, stirred (35-45 rpm), heated to 65-75°C, and then homogenized (700-1500 rpm). The first mixing is carried out while maintaining stirring and homogenization. This invention mixes panthenol and diethoxyethyl succinate under high temperature (65-75°C) and homogenized shear conditions, forming a supramolecular complex.

[0035] After obtaining the first mixture, the present invention performs a second mixture with an alcohol solvent and a preservative to obtain a second mixture.

[0036] In this invention, the second mixing method is preferably as follows: dissolving the alcohol solvent and the preservative under heating conditions, and then adding the dissolved mixture to the first mixture (in an emulsifying pot) for mixing. In this invention, the heating temperature is preferably 65-75°C, and can be 70°C, and the dissolution is preferably carried out under stirring.

[0037] After obtaining the second mixture, the present invention mixes the second mixture with water to obtain the third mixture.

[0038] The present invention preferably adds the water to the second mixture (in the emulsifying pot).

[0039] In obtaining the third mixture, the present invention further mixes the third mixture with the papain and hydrolyzed red algae extract in the repair composition to obtain the repair essence.

[0040] In this invention, when the papain and hydrolyzed red algae extract in the repair composition are mixed in the fourth step, the temperature of the third mixture is preferably 30-40°C, and can be 35°C. Specifically, the third mixture is cooled to 30-40°C, and then the papain and hydrolyzed red algae extract are added to it. Papain has biological activity but is not heat-resistant, and the polysaccharides and proteins in the hydrolyzed red algae extract are also prone to denaturation and aggregation at high temperatures; therefore, in this invention, the third mixture is cooled before the papain and hydrolyzed red algae extract are added.

[0041] In this invention, the second, third, and fourth mixing are preferably carried out under stirring and homogenization conditions, and the stirring and homogenization rate is preferably the same as the stirring and homogenization rate during the first mixing.

[0042] To further illustrate the present invention, the following detailed descriptions, in conjunction with examples, illustrate the repair compositions and their applications, as well as the repair serums and their preparation methods, but these should not be construed as limiting the scope of protection of the present invention.

[0043] In this example, the hydrolyzed red algae extract was purchased from Chemisches Laboratorium Dr. Kurt Richter GmbH (CLR), under the trade name CutiGuard CLR. TM Papain was purchased from Zhengzhou Kema Biotechnology Co., Ltd., under the trade name PROTESSE G66.

[0044] Examples 1-5 The formulations of the repair serums in Examples 1-5 are shown in Table 1. The preparation steps of the repair serums in these examples are as follows: (1) Add panthenol and diethoxyethyl succinate to the emulsifying pot, stir (40 rpm) and heat to 70°C, then homogenize (1000 rpm) for 5 minutes; (2) Take another container, add 1,3-propanediol, 1,2-hexanediol and p-hydroxyacetophenone, stir and heat to 70°C, dissolve evenly and then add to the emulsification pot and mix evenly; (3) Add water to the emulsifying pot, mix well, and then cool to 35°C; (4) Add papain and hydrolyzed red algae extract to the emulsifying pot, mix well, and obtain the repair essence.

[0045] Comparative Examples 1-4 The formulations of the repair serums in Comparative Examples 1-4 are shown in Table 1. The preparation of the repair serums in Comparative Examples 1-4 follows the same principles as the examples, except that the corresponding components in Table 1 can be omitted.

[0046] Comparative Example 5 The formulation of the repair essence in Comparative Example 5 is the same as that in Example 2. The difference between the preparation of the repair essence in Comparative Example 5 and Example 2 is that steps (1) and (2) are adjusted as follows: panthenol and diethoxyethyl succinate are added to the emulsification pot, stirred (40 rpm) and heated to 45°C, and homogenized (1000 rpm) for 5 minutes; (2) in another container, 1,3-propanediol, 1,2-hexanediol and p-hydroxyacetophenone are added, stirred and heated to 70°C, dissolved evenly and then cooled to 45°C, added to the emulsification pot and mixed evenly; the remaining steps are the same as in Example 2.

[0047] Table 1. Formulation composition (parts by weight) of the repair serums in Examples 1-5 and Comparative Examples 1-4.

[0048] The performance of the repair serums in Examples 1-5 and Comparative Examples 1-5 was tested, as follows: (a) Stickiness test Testing method: Subjective sensory evaluation method Professional evaluation team (expert assessment), personnel requirements: 8 fixed evaluators who have undergone rigorous screening and training and can accurately identify and describe different degrees of stickiness.

[0049] Evaluation conditions: room temperature 20~22℃, humidity 50~60%RH.

[0050] Evaluation process: 1. Cleanse your hands with facial cleanser and wipe them clean with a disposable facial wipe.

[0051] 2. Use a disposable dropper to draw 0.5mL of the essence and apply it evenly to the skin on the back of your hand.

[0052] 3. At the 0, 1, 3 and 5 minutes, gently press and pull the skin with your fingers to feel the stickiness.

[0053] 4. Repeat the above process to evaluate each embodiment and comparative example in turn.

[0054] Evaluation scale: Numerical rating scale (1~10 points) 10 / 10: Completely non-sticky, dry and smooth.

[0055] 5 points: Medium stickiness, perceptible but not unpleasant.

[0056] 0 points: Extremely sticky, uncomfortable, and feels like the skin is stuck together.

[0057] The results of the stickiness test are shown in Table 2.

[0058] Table 2. Results of the stickiness test of the repair serums in Examples 1-5 and Comparative Examples 1-5.

[0059] (ii) Panthenol Permeability Test Permeability test (using panthenol as the calibrator) 1. Test method: Refer to GB / T27818-2011 "In vitro test method for skin absorption of chemicals", laboratory method "NR-TW-ST01-permeability enhancement-transdermal absorption test of cosmetics".

[0060] 2. Reagents and consumables are shown in Table 3. Table 3 Reagents and Consumables

[0061] 3. Experimental Procedure (1) Prepare 100mg / mL panthenol solution: Weigh 100mg of panthenol and add it to a volumetric flask, then add ultrapure water to make up to volume and shake to mix evenly.

[0062] (2) Use scissors to cut pig skin into small pieces of a fixed size, add them to DPBS solution for washing, and then use filter paper to blot dry. Divide the pig skin into blank control group, panthenol experimental group, example experimental group, and comparative experimental group, with 3 pieces in each group.

[0063] (3) Add receiving solution to the receiving chamber: Use a pipette to draw 6.0 mL of receiving solution (DPBS) and inject it into the receiving chamber, and place the matching magnetic stir bar in the receiving chamber.

[0064] (4) Assembly and fixation of the test model: The piglet skin was fixed between the supply chamber and the receiving chamber of the Franzcell diffusion cell, with the stratum corneum of the piglet skin facing the supply chamber and the dermis facing the receiving chamber. After fixing the piglet skin, 1.0 mL of receiving solution (DPBS) was added to the sampling tube using a pipette according to the liquid level in the sampling tube, so that the dermis of the piglet skin was in close contact with the receiving solution, and the total volume of the receiving solution was 7.0 mL.

[0065] (5) Fix the Franzcell diffusion cell in the transdermal absorption diffusion apparatus, turn on the electromagnetic stirrer and stir at a speed of 300 rpm, maintain a constant temperature water bath of (32±1)℃, and ensure that there are no air bubbles in the water bath jacket.

[0066] (6) Sample loading: After the water bath temperature of the diffuser is constant, sample loading is performed. The essence samples of Examples 1-5 and Comparative Examples 1-5 and the panthenol solution are added to the supply chamber respectively. The blank control group is only added with DPBS solution.

[0067] (7) Subcutaneous sample collection: At time points of 0h and 0.5h, 0.3mL of receiving fluid was drawn with a syringe and placed in a 1.5mL EP tube. Then, 0.3mL of DPBS solution was added to the receiving chamber with a syringe.

[0068] (8) The panthenol content was quantitatively analyzed by sampling at each time point using high performance liquid chromatography (HPLC).

[0069] 4. Data processing: Based on the content of continuous testing, the transdermal absorption effect was compared. The data are shown in Table 4.

[0070] Table 4. Results of Transdermal Absorption Test

[0071] Note: Statistical analysis was performed using the t-est method. This indicates a significant difference compared to the control group (p < 0.05).

[0072] As shown in Table 4, compared with the panthenol control group, the concentration of panthenol in the receiving chamber of Examples 2-5 was significantly increased after 0.5 hours of treatment with the essence of the examples and comparative examples, with significant differences (P<0.05).

[0073] (III) Test of Soothing and Repairing Effects 1. Testing Method T / CAB0152-2022 "Test Methods for Seven Efficacy Items of Cosmetics: Anti-wrinkle, Firming, Moisturizing, Oil Control, Repairing, Nourishing and Soothing" and GHS-SOP-G-120 "Test Methods for Skin Hemoglobin".

[0074] 2. Testing instruments Multifunctional skin testing system, CK, Germany, with Mexameter® MX18 probe.

[0075] 3. Method Principles Skin Hemoglobin Testing Method: This instrument is based on the principle of spectral absorption (RGB). It determines the content of melanin and hemoglobin in the skin by measuring the amount of light reflected after a specific wavelength of light shines on the skin. The instrument's probe emits light with wavelengths of 568nm, 660nm, and 880nm, which shines on the skin surface. The receiver measures the light reflected from the skin. Since the amount of emitted light is constant, the amount of light absorbed by the skin can be measured, thus determining the skin hemoglobin content. The instrument's measurement range is 0-999; the higher the measured value, the higher the hemoglobin content in the skin.

[0076] 4. Evaluation Scheme 4.1 Study Design: Subjects were divided into 9 groups of 8 people each. They used the evaluation sample continuously for 7 days in a double-blind evaluation. The night before the evaluation began, subjects washed their faces without applying any sample. Evaluation time points: before use (D0), 15 minutes after use (15 min), and 7 days after use (D7). Evaluation parameter: skin hemoglobin.

[0077] 4.2 Environmental conditions: Temperature 21℃±1℃, relative humidity 50±10%RH. Visual assessment was conducted under constant lighting conditions (fluorescent tube illumination with a color temperature of 5500~6500K), and all subjects were required to sit still and maintain balance for at least 30 minutes under these environmental conditions before assessment and evaluation could begin.

[0078] 4.3 Evaluation Methods Apply an appropriate amount of serum to the face every morning and evening, gently massaging until absorbed. Use daily for 7 consecutive days. Facial skin indicators (skin hemoglobin) are evaluated using instruments at D0, 15min, and D7.

[0079] 4.4 Evaluation Results The results of the skin hemoglobin (Mexameter, MX 18) test are shown in Table 5 (expressed as erythema index).

[0080] Table 5 Results of the skin hemoglobin test (X±SD)

[0081] As shown in Table 5, compared with before using the serum sample, 15 minutes after using the sample, the reduction level of skin hemoglobin in the subjects' evaluation areas was 19.28% in Example 2 and 16.44% in Example 3, with significant differences. After 7 days of using the sample, the reduction level of skin hemoglobin in the subjects' evaluation areas was 16.64% in Example 2 and 14.19% in Example 3, with significant differences.

[0082] As can be seen from the above embodiments, the repair essence (panthenol content ≥10%) provided by the present invention has good skin feel, transdermal absorption performance and soothing and repairing effect.

[0083] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A repair composition, characterized in that, The components include the following parts by mass: Panthenol 5-15 parts, diethoxyethyl succinate 0.5-3 parts, hydrolyzed red algae extract 0.1-3 parts, papain 0.01-0.1 parts.

2. The repair composition according to claim 1, characterized in that, The components include the following parts by mass: Panthenol 10-13 parts, diethoxyethyl succinate 1-3 parts, hydrolyzed red algae extract 1-3 parts, papain 0.05-0.1 parts.

3. The use of the repair composition according to claim 1 or 2 in skin care products.

4. The application according to claim 3, characterized in that, The skincare products include serums.

5. A repairing essence, characterized in that, The components include the following components by mass percentage: The repair composition comprises 5.61-21.1% alcohol solvent, 5-15% preservative, 0.5-2% water, and the balance being the repair composition as described in claim 1 or 2.

6. The repairing essence according to claim 5, characterized in that, The alcohol solvent includes one or more of 1,3-propanediol, glycerol, and 1,3-butanediol, and the preservative includes 1,2-hexanediol and p-hydroxyacetophenone, wherein the mass ratio of 1,2-hexanediol to p-hydroxyacetophenone is 1:

1.

7. The method for preparing the repair essence according to claim 5 or 6, characterized in that, Includes the following steps: Panthenol and diethoxyethyl succinate in the repair composition are first mixed to obtain a first mixture; the temperature of the first mixing is 65~75°C. The first mixture is then mixed with an alcohol solvent and a preservative to obtain a second mixture; The second mixture is then mixed with water to obtain a third mixture; The third mixture is then mixed with the papain and hydrolyzed red algae extract in the repair composition to obtain the repair essence.

8. The preparation method according to claim 7, characterized in that, The first mixing is carried out under stirring and homogenization conditions, wherein the stirring rate is 35-45 rpm, the homogenization rate is 700-1500 rpm, and the first mixing time is 4-7 minutes.

9. The preparation method according to claim 7, characterized in that, The second mixing method is as follows: the alcohol solvent and the preservative are dissolved under heating conditions, and the dissolved mixture is added to the first mixture for mixing; the heating temperature is 65~75℃.

10. The preparation method according to claim 7, characterized in that, When the papain and hydrolyzed red algae extract in the repair composition are mixed for the fourth time, the temperature of the third mixture is 30-40°C.

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