Animal experiment device capable of controlling gas concentration
By using the flow coupon and the flow coupon in the animal experimental device to buffer the gas into the box, and combining the gas concentration sensor and control unit to automatically adjust the gas flow rate, the problems of uneven gas concentration and complex operation are solved, and the gas concentration is achieved. Stability and uniformity improve experimental accuracy and reduce the working intensity of the experimenter.
Patent Information
- Application Number
- CN202420207357.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-01-29
- Publication Date
- 2024-12-10
- Estimated Expiration
- 2034-01-29
AI Technical Summary
Existing animal experimental devices have problems of uneven distribution and complex operation in maintaining constant gas concentration, especially in the long-term experiment, the gas concentration needs to be frequently detected to prevent deviations, resulting in inefficient experiments.
A device including a sealed box, a flow-to-equipped box, a flow-to-equipped plate, an intake pipe, an outlet pipe, a gas concentration sensor and a gas flow-to-equipped valve are designed, and gas is buffered into the box through the flow-to-equipped box and a flow-to-equipped plate, combined with The control unit automatically adjusts the gas flow rate to ensure that the gas concentration is evenly distributed within the preset range, and an alarm is set at the outlet pipe to prevent abnormal conditions.
The stability and uniformity of gas concentration are achieved, the working intensity of the experimenters is reduced, the experimental accuracy is improved, and the fluctuations in gas concentration are reduced during long-term experiments, and the alarm is promptly issued to prevent toxic gas leakage.
Smart Images
Figure CN222130307U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of animal experiment facilities, in particular to an animal experiment device with controllable gas concentration. Background Art
[0002] Animal experiments are an important means in drug development and medical research. Especially in pharmacological experiments, animals have become indispensable experimental subjects. For example, mice, rats, rabbits, etc., these animals have strong reproductive capacity, low price, and controllable living conditions. By observing the physiological reactions and changes in biochemical indicators of these animals under the action of drugs, the efficacy and mechanism of action of drugs can be evaluated; by studying the absorption, distribution, metabolism and excretion of drugs in animals, the metabolic characteristics and duration of action of drugs can be understood; in addition, by observing the adverse reactions and toxic reactions of animals under the action of drugs, the safety of drugs can be evaluated and the risks of clinical trials can be reduced.
[0003] In pharmacological experiments, animals are often placed under constant gas concentrations for cultivation, such as oxygen, sulfur dioxide, etc., and the relevant parameters of the animals are detected to evaluate the effect of drugs or study the toxic mechanism of toxic gases on animals. Currently, commonly used experimental devices can be roughly divided into two categories. One is a multi-kinetic integrated experimental device, which is equipped with various functional modules and can automatically adjust experimental environment parameters such as temperature and humidity as well as conditions such as gas flow rate. Such devices are expensive, complicated to operate, and have high maintenance costs. The other is a relatively simple device, which is mostly a box structure with an inlet and outlet pipe, through which the gas concentration is kept constant. However, affected by factors such as the respiratory condition of experimental animals and the internal environment of the device, the gas concentration in such devices is often constantly changing. The inlet and outlet pipe method alone cannot effectively ensure the constant gas concentration inside the device, and when the gas flow rate is too large, it is easy to cause uneven gas distribution inside the device. In addition, when the animal culture time reaches several days or even dozens of days, the experimenter is required to regularly detect the gas concentration every day to prevent the concentration from deviating and affecting the detection effect, which is time-consuming and laborious. Utility Model Content
[0004] In order to solve the problems of the above-mentioned prior art, the utility model provides an animal experimental device with controllable gas concentration. The experimental device can automatically adjust the concentration of the experimental gas so that the gas concentration in the device is stably maintained within a certain range and is evenly distributed; the entire device has a simple structure, is easy to operate, and saves time and effort.
[0005] The utility model is specifically implemented through the following technical solutions:
[0006] An animal experiment device with controllable gas concentration comprises a sealed box for placing an animal feeding box; the side wall of the sealed box is connected to an air outlet pipe, and a flow equalizing box is arranged on the top; a flow equalizing plate is arranged at the lower end of the flow equalizing box, and an air inlet pipe is connected to the top; a plurality of air vents are evenly distributed on the flow equalizing plate; the air inlet pipe is connected to an experimental gas source through a gas flow control valve; an experimental gas concentration sensor is arranged on the air outlet pipe; the experimental gas concentration sensor, the gas flow control valve and a control unit are electrically connected; the control unit adjusts the gas flow control valve according to the value detected by the gas concentration sensor, so that the experimental gas in the inner cavity of the box is kept within a preset range.
[0007] The utility model provides an animal experiment device with controllable gas concentration by arranging a flow equalizing box above the box body, and arranging a flow equalizing plate at the connection between the flow equalizing box and the box body, so that the experimental gas in the air intake pipe first enters the flow equalizing box for buffering, and then slowly penetrates into the box body through the flow equalizing plate, thereby preventing the experimental gas from directly and rapidly entering the box body in large quantities through the air intake pipe, resulting in excessively high local gas concentration at the center of the air intake pipe in the box body and excessively low local gas concentration at the edge of the box body, and also preventing the experimental gas from rapidly being discharged from the side air outlet pipe after entering the box body through the air intake pipe, resulting in uneven dispersion, thereby effectively ensuring the uniformity of the experimental gas inside the box body. The utility model also has a gas concentration sensor at the outlet pipe, a gas flow control valve on the inlet pipe, and the gas concentration sensor, the gas flow control valve and the control unit are electrically connected. The gas concentration sensor can detect the concentration value of the experimental gas in the outlet pipe. When the gas concentration value is too large or too small, a signal can be sent to the control unit. After receiving the signal, the control unit can control the gas flow control valve to adjust the gas flow in the inlet pipe, so that the gas concentration is always kept stable within a preset range, avoiding gas concentration fluctuations caused by factors such as animal breathing conditions, the internal environment of the device, and insufficient experimental gas source content, ensuring that all animals in the device are in the same experimental conditions, and improving the accuracy of the experiment. For long-term cultivation needs, the device of the utility model does not need to detect the concentration of the gas regularly every day, which effectively reduces the workload of the experimenter.
[0008] Preferably, the animal experiment device with controllable gas concentration also includes an alarm, which is electrically connected to the control unit; its beneficial effect is that: an alarm is arranged in the device, and the alarm is electrically connected to the control unit, when the device is damaged and leaks, the gas in the gas source is exhausted, etc., causing the gas content of the device to be lower than (or higher than) the minimum value (or maximum value, both of which can be adjusted according to experimental requirements), the gas concentration sensor can send a signal to the control unit, and the control unit controls the alarm to sound an alarm to remind the experimenter of the abnormal situation of the device, effectively avoiding the occurrence of dangerous situations, especially leakage when the experimental gas is toxic.
[0009] Preferably, several of the animal feeding boxes are evenly distributed under the flow equalizing plate; the beneficial effect is that the animal feeding boxes are evenly distributed under the flow equalizing plate to ensure that each experimental animal is in the same gas concentration environment, thereby improving the accuracy of the experiment.
[0010] Preferably, a carbon dioxide absorber or a water vapor absorber is provided in the sealed box; its beneficial effect is that an additional carbon dioxide absorber or a water vapor absorber is provided inside the box, which can absorb the carbon dioxide or water vapor produced by the animals, thereby ensuring the long-term survival of the animals in the box, and also reducing the impact of carbon dioxide or water vapor on the gas concentration sensor.
[0011] Further preferably, the carbon dioxide absorber includes soda lime, specifically an open container filled with soda lime; the water vapor absorber includes silica gel, specifically an open container filled with silica gel.
[0012] Preferably, the top of the flow equalizing box is detachably connected to a top plate, and the air inlet pipe is connected to the top plate; its beneficial effect is that the top plate is detachably connected to the top of the flow equalizing box, which makes it convenient to put items such as animal feeding boxes into the box body, and the box body and the flow equalizing box as a whole only have one opening on the top plate, and the rest of the structure is an integrated sealing structure, which reduces the probability of air leakage in the box body.
[0013] Further preferably, a plurality of spring locks are provided on the outer side wall of the flow balancing box; and a hook compatible with the spring lock is provided on the top plate. The beneficial effect is that the top plate is fixed to the flow balancing box by the spring lock, which is not only firmly fixed and has a good sealing effect, but also convenient to operate.
[0014] Further preferably, a sealing strip is provided at the connection between the flow equalizing box and the top plate; the beneficial effect thereof is that the sealing strip is used to seal the connection between the top plate and the flow equalizing box, thereby further improving the overall sealing effect of the box body and ensuring the stability of the internal experimental gas concentration.
[0015] Preferably, the sealed box and the flow equalizing box are transparent; the beneficial effect is that by setting the box and the flow equalizing box to be transparent, the real-time situation of the animals in the box can be easily observed at any time, and some dangers can also be predicted in advance.
[0016] Preferably, a plurality of self-locking universal wheels are provided at the bottom of the sealed box; the beneficial effect is that the overall structure of the box is relatively large and inconvenient to carry, and the self-locking universal wheels are provided at the bottom of the box, which facilitates the experimenter to adjust the position of the box according to the experimental environment.
[0017] Compared with the prior art, the beneficial effects of the utility model are:
[0018] (1) The gas concentration controllable animal experiment device of the utility model can automatically adjust the gas concentration by setting a flow equalizing box and a flow equalizing plate, and cooperating with a gas concentration sensor, a gas flow control valve and a control unit, so that the gas concentration in the device is stably maintained within a certain range and the gas is evenly distributed in the box.
[0019] (2) The gas concentration controllable animal experiment device of the utility model is equipped with an alarm, which can promptly give an alarm when an abnormal situation occurs, effectively avoiding the occurrence of dangerous situations such as toxic gas leakage.
[0020] (3) The gas concentration controllable animal experiment device of the utility model has a simple structure and is easy to operate. BRIEF DESCRIPTION OF THE DRAWINGS
[0021] Figure 1 It is a structural schematic diagram of the animal experiment device with controllable gas concentration described in the embodiment;
[0022] Figure 2 It is a structural schematic diagram of the current equalizing plate described in the embodiment;
[0023] Figure 3 It is a schematic diagram of the structure of the spring lock, hook and sealing strip described in the embodiment.
[0024] In the figure: 1. Sealed box; 2. Air outlet pipe; 3. Flow equalizing box; 4. Flow equalizing plate; 5. Air inlet pipe; 6. Gas flow control valve; 7. Experimental gas source; 8. Experimental gas concentration sensor; 9. Animal breeding box; 10. Carbon dioxide absorber; 11. Water vapor absorber; 12. Top plate; 13. Spring lock; 14. Hook; 15. Sealing strip; 16. Self-locking universal wheel; 17. Vent. DETAILED DESCRIPTION
[0025] The following will clearly and completely describe the technical solutions of each embodiment of this patent in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of this patent, not all of them. Based on the embodiments of this patent, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this patent.
[0026] The present invention is further described in detail below through specific implementation examples and in conjunction with the accompanying drawings.
[0027] Example
[0028] like Figures 1 to 3As shown, this embodiment provides an animal experimental device with controllable gas concentration, which includes a sealed box 1 for placing an animal breeding box, an air outlet pipe 2 is connected to the side wall of the sealed box 1, and a flow equalizing box 3 is provided on the top; a flow equalizing plate 4 is provided at the lower end of the flow equalizing box 3, and an air inlet pipe 5 is connected to the top; a number of air vents 17 are evenly distributed on the flow equalizing plate 4; the air inlet pipe 5 is connected to the experimental gas source 7 through a gas flow control valve 6; an experimental gas concentration sensor 8 is provided on the air outlet pipe 2; the experimental gas concentration sensor 8, the gas flow control valve 6 and the control unit (the position of the control unit is not shown in the figure, and its specific position can be set according to the actual situation of the laboratory) are electrically connected; the control unit adjusts the gas flow control valve according to the numerical value detected by the gas concentration sensor, so that the experimental gas in the inner cavity of the box is kept within a preset range.
[0029] By arranging a flow equalizing box and a flow equalizing plate above the box, the experimental gas in the gas source can first enter the flow equalizing box for buffering, and then slowly penetrate into the box through the flow equalizing plate, thereby avoiding the problem that the experimental gas directly enters the box in large quantities and quickly from the air inlet pipe, resulting in the problem that the local gas concentration at the center of the air inlet pipe in the box is too high and the local gas concentration at the edge of the box is too low, and the uniformity of the experimental gas inside the box is effectively guaranteed. In addition, by electrically connecting the gas concentration sensor, the gas flow control valve and the control unit, the gas concentration sensor can detect the concentration value of the experimental gas in the air outlet pipe. When the gas concentration value is too large or too small, a signal can be sent to the control unit. After receiving the signal, the control unit can adjust the gas flow in the air inlet pipe by controlling the gas flow control valve, so that the gas concentration is always kept stable within a preset range, avoiding gas concentration fluctuations caused by factors such as animal breathing conditions, internal environment of the device, and insufficient experimental gas source content, ensuring that all animals in the device are in the same experimental conditions, and improving the accuracy of the experiment. The flow equalizing box, flow equalizing plate and the entire gas concentration adjustment system cooperate with each other to effectively ensure that the gas concentration in the device is stably maintained within a certain range and the gas is evenly distributed in the box.
[0030] The experimental gas is oxygen, sulfur dioxide, etc., the gas source is a container filled with the experimental gas, such as an oxygen cylinder; the gas flow control valve is an electromagnetic flow valve.
[0031] Optionally, the animal experiment device with controllable gas concentration also includes an alarm (not shown in the figure, and its specific position can be set according to the actual situation of the laboratory), and the alarm is electrically connected to the control unit. An alarm is set in the device, and the alarm is electrically connected to the control unit. When the device is damaged and leaks, the gas in the gas source is exhausted, etc., causing the gas content of the device to be lower than (or higher than) the minimum value (or maximum value, both of which can be adjusted according to experimental requirements), the gas concentration sensor can send a signal to the control unit, and the control unit controls the alarm to send an alarm to remind the experimenter of the abnormal situation of the device, effectively avoiding the occurrence of dangerous situations, especially when the experimental gas is a toxic gas. Leakage.
[0032] Optional, such as Figure 1 As shown, a plurality of the animal feeding boxes 9 are evenly distributed under the flow equalizing plate 4. The animal feeding boxes are evenly distributed under the air permeable plate to ensure that each experimental animal is in the same gas concentration environment, thereby improving the accuracy of the experiment.
[0033] The number of animal feeding boxes can be adjusted according to the experimental needs; optionally, a barrier bar is set on the top of the animal feeding box. On the one hand, the barrier bar can limit the animal's range of activities, prevent the animal from running out, keep the animal in a relatively stable state, and reduce the fluctuation of gas absorption caused by movement; on the other hand, it can also facilitate the uniform absorption of experimental gas by each animal in the feeding box. For experiments with a longer period, food and water sources can also be placed on the barrier bar to facilitate animal intake and ensure the normal survival of the animal.
[0034] Optional, such as Figure 1 As shown, the sealed box 1 is provided with a carbon dioxide absorber 10 and a water vapor absorber 11. The carbon dioxide absorber and the water vapor absorber are additionally provided inside the box to absorb the carbon dioxide and water vapor produced by the animals, thereby ensuring the long-term survival of the animals in the box, and also reducing the influence of carbon dioxide and water vapor on the gas concentration sensor.
[0035] Further optionally, the carbon dioxide absorber is an open box filled with soda lime; the water vapor absorber is an open box filled with silica gel.
[0036] The positions of the carbon dioxide absorber and the water vapor absorber are not fixed. Optionally, the two are evenly spaced and arranged around the animal feeding box.
[0037] Optional, such as Figure 1 As shown, the top of the flow balancing box 3 is detachably connected to a top plate 12, and the air intake pipe 5 is connected to the top plate 12. The top plate can be detachably connected to the top of the flow balancing box, which facilitates the placement of items such as animal feeding boxes into the box. The box and the flow balancing box as a whole only have one opening on the top plate, and the rest of the places are all integrated sealing structures, which reduces the probability of air leakage in the box.
[0038] Further optional, such as Figure 3 As shown, a plurality of spring locks 13 are provided on the outer wall of the flow balancing box 3; and a hook 14 adapted to the spring locks 13 is provided on the top plate 12. The top plate is fixed to the flow balancing box by the spring locks, which is not only firmly fixed, has a good sealing effect, but also convenient to operate. The number of spring locks can be set according to the sealing requirements, and there is no less than one spring lock on each side of the top plate.
[0039] Further optional, such as Figure 3 As shown, a sealing strip 15 is provided at the connection between the flow balancing box 3 and the top plate 12. The sealing strip is used to seal the connection between the top plate and the flow balancing box, further improving the sealing effect of the box as a whole and ensuring the stability of the internal experimental gas concentration.
[0040] Optionally, the sealed box and the flow equalizer are transparent. The box and the flow equalizer are transparent, which can be convenient for observing the real-time situation of the animals in the box at any time, and some dangers can be predicted in advance; the sealed box and the flow equalizer can be made of glass.
[0041] Optional, such as Figure 1 As shown, the bottom of the sealed box is provided with a plurality of self-locking universal wheels. The overall structure of the box is relatively large and inconvenient to carry. The self-locking universal wheels are provided at the bottom of the box, which facilitates the experimenter to adjust the position of the box according to the experimental environment.
[0042] The above embodiments describe the implementation of the present invention in detail, but the present invention is not limited to the specific details in the above embodiments. Within the scope of the claims and technical concept of the present invention, the technical solution of the present invention can be modified and changed in many simple ways, and these simple modifications all belong to the protection scope of the present invention.
Claims
1. An animal experiment device with controllable gas concentration, It is characterized in that It comprises a sealed box for placing an animal feeding box; the side wall of the sealed box is connected to an air outlet pipe, and a flow equalizing box is arranged on the top; a flow equalizing plate is arranged at the lower end of the flow equalizing box, and an air inlet pipe is connected to the top; a plurality of air vents are evenly distributed on the flow equalizing plate; the air inlet pipe is connected to an experimental gas source through a gas flow control valve; an experimental gas concentration sensor is arranged on the air outlet pipe; the experimental gas concentration sensor, the gas flow control valve and the control unit are electrically connected.
2. An animal experiment device with controllable gas concentration according to claim 1, It is characterized in that The animal experiment device also includes an alarm, which is electrically connected to the control unit.
3. An animal experiment device with controllable gas concentration according to claim 1, It is characterized in that A plurality of animal feeding boxes are evenly distributed below the flow equalizing plate.
4. The animal experiment device with controllable gas concentration according to claim 1, It is characterized in that The sealed box is provided with a carbon dioxide absorber or a water vapor absorber.
5. An animal experiment device with controllable gas concentration according to claim 4, It is characterized in that The carbon dioxide absorber comprises soda lime; the water vapor absorber comprises silica gel.
6. The animal experiment device with controllable gas concentration according to claim 1, It is characterized in that The top of the flow equalizing box is detachably connected with a top plate, and the air intake pipe is connected to the top plate.
7. An animal experiment device with controllable gas concentration according to claim 6, It is characterized in that A plurality of spring lock buckles are arranged on the outer side wall of the flow balancing box; and a hook matched with the spring lock buckles is arranged on the top plate.
8. An animal experiment device with controllable gas concentration according to claim 6, It is characterized in that A sealing strip is provided at the connection between the flow balancing box and the top plate.
9. The animal experiment device with controllable gas concentration according to claim 1, It is characterized in that The sealed box body and the flow equalizing box are transparent.
10. The animal experiment device with controllable gas concentration according to claim 1, It is characterized in that A plurality of self-locking universal wheels are arranged at the bottom of the sealed box.