Auxiliary fixing device for mouse external application medicine experiment

Abstract

The utility model discloses an auxiliary fixing device for a mouse external application medicine experiment. The auxiliary fixing device comprises a liquid collecting box, an experiment box, a dropper assembly and an external application medicine bag, the liquid collecting box and the experiment box are of hollow structures, and the front ends are connected through a rotating shaft; through grooves are formed in the upper ends of the two sides of the experiment box, the dropper assemblies are connected to the two ends of the through grooves and extend out of the experiment box, and the positions of the dropper assemblies on the through grooves are adjusted through fixing assemblies arranged on the through grooves. The external application medicine bag is connected to one end of the dropper assembly; the rear end of the liquid collecting box is rotationally connected with a telescopic supporting rod; a square groove is formed in the side wall of the bottom of the experiment box; the angle between the liquid collecting box and the experiment box is controlled by telescopically adjusting the relative position between the supporting rod and the square groove; according to the utility model, an experiment can be carried out on a mouse in a living body state, and meanwhile, the mouse can exist in a posture with a low head and a high tail, so that the activity of the mouse is reduced, the mouse can be continuously dosed, and excrement generated by the mouse can be collected and treated.

Description

Technical Field

[0001] The utility model belongs to the technical field of experimental animal fixation, and in particular relates to an auxiliary fixation device for mouse external application medicine experiments. Background Art

[0002] Mice are commonly used experimental animals in biomedical research. Due to their high physiological and genetic similarities with humans, they have become an important model for studying disease treatment and drug development. In mouse topical drug experiments, in order to ensure continuous contact with the drug and prevent the animal from eating, licking or cleaning its body and interfering with the experimental results, it is usually necessary to use a fixation device to assist.

[0003] At present, common auxiliary fixation devices for mouse topical drug experiments mainly include neck rings, straps and closed devices. However, these traditional devices have some limitations. For example, neck ring fixation may cause discomfort to mice, the tightness of the straps is difficult to adjust, and the closed device may hinder the normal movement of mice. In addition, for mouse topical drug experiments, mice are generally anesthetized first and then subjected to topical drug experiments. During the experiment, the topical drug experiment on mice may take several hours. During this process, the mice may die due to continuous medication and anesthesia. In addition, the traditional fixation method is to fix them directly in a horizontal state and then conduct the experiment. During the experiment, the mice may bite and move violently, which will disrupt the experimental process and affect the experimental results. In addition, during the experiment, because the mice are in a state of stimulation and tension, they may have irritating defecation or autonomous defecation. If there is no corresponding receiving device, the excreted waste may contaminate the experimental table.

[0004] Therefore, there is a need for an auxiliary fixation device for mouse topical drug experiments, which can perform skin topical drug experiments without anesthetizing the mice, ensuring that the experiments can be performed in a living state and the accuracy of the experimental results. In addition, the device can allow the mice to exist in a posture with their heads low and their tails high, reducing the activity of the mice and ensuring that the mice can be tested in a basically quiet state; and the device can continuously administer drugs to the mice to ensure the continuity of the topical drugs, and can also collect and process the feces produced by the mice to prevent their feces from contaminating the device. Utility Model Content

[0005] In order to solve the above technical problems and achieve the above technical effects, the utility model designs an auxiliary fixing device for mouse external medicine application experiment, comprising: a liquid collecting box, an experimental box, a dropper, and an external medicine bag; the liquid collecting box and the experimental box are hollow structures, and the front ends are connected by a rotating shaft; through grooves are opened at the upper ends of both sides of the experimental box, the dropper is connected to the two ends of the through groove and extends out of the experimental box, and the position of the dropper on the through groove is adjusted by a fixing component arranged on the through groove; the external medicine bag is connected to one end of the dropper; the rear end of the liquid collecting box is rotatably connected to the telescopic support rod; the bottom side wall of the experimental box is provided with a square groove; the angle between the liquid collecting box and the experimental box is controlled by telescopically adjusting the relative position between the support rod and the square groove;

[0006] Furthermore, a square groove is formed at the front end of the liquid collecting box, and a liquid collecting box is movably installed in the square groove; a handle is provided in the middle of the liquid collecting box;

[0007] Furthermore, both sides of the rear end of the liquid collecting box are rotatably connected with telescopic rod assemblies, and the front end of the telescopic rod assembly is provided with a movable groove;

[0008] Furthermore, a square groove is opened in the middle and lower part of the experimental box, a feces collection plate is slidably installed in the square groove, and the feces collection plate has through holes in a linear array; a supporting frame is fixedly installed on the upper end of the feces collection plate, and a grid is provided in a linear array on the supporting frame;

[0009] Furthermore, the front end of the dropper has a linear array of circular holes, the circular holes are connected to connecting tubes, and the front end of the connecting tubes is fixedly connected to the dressing patch;

[0010] Furthermore, a connecting wire is provided at the rear side of the upper end of the experimental box, and a fixing clip is connected to the front end of the connecting wire;

[0011] Furthermore, the lower end of the external medicine bag is connected to the dripping tube through a guide tube, and a flow rate switch is provided on the dripping tube; the upper end of the external medicine bag is provided with a medicine injection port, and the upper end of the medicine injection port is connected to a hook;

[0012] Furthermore, the fixing assembly includes a connecting piece and an adjusting knob; holes are opened at both ends of the connecting piece, one end is connected to the drip tube, and the other end is connected to the adjusting knob;

[0013] The beneficial effects of the utility model are:

[0014] The utility model connects the drip tube to the two ends of the through slot and extends it outside the experimental box, and adjusts the position of the drip tube on the through slot by means of a fixing assembly arranged on the through slot; compared with the traditional device, the position of mice of different lengths can be adjusted, and the application range is wider; secondly, the utility model controls the angle between the liquid collecting box and the experimental box by means of the relative position between the telescopic adjustment support rod at the rear end of the liquid collecting box and the square groove on the side wall at the lower end of the experimental box; compared with the traditional device, the angle between the liquid collecting box and the experimental box can be adjusted, so that the mouse is in a state of head low and tail high, so that the small The mice are kept relatively quiet, which can reduce the activity of the mice and reduce their interference with the experimental results. In addition, compared with traditional devices, the utility model can ensure that the mice are tested in a living state, and experiments can be carried out without anesthesia. A square groove is opened in the middle and lower part of the experimental box, and a feces collection plate is slidably installed in the square groove, and the feces collection plate has a linear array of through holes; a supporting frame is fixedly installed on the upper end of the feces collection plate, and a linear array of grids is provided on the supporting frame; the stimulating defecation or autonomous defecation of the mice, as well as the exuded liquid medicine can be collected separately to avoid contaminating the experimental table. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings required for describing the embodiments are briefly introduced below.

[0016] Figure 1 It is a schematic diagram of the overall structure of an auxiliary fixing device for mouse external application drug experiment;

[0017] Figure 2 It is another overall structural schematic diagram of an auxiliary fixing device for mouse external application drug experiment;

[0018] Figure 3 The figure is a schematic diagram of the overall structure of a mouse external medicine experiment auxiliary fixing device after removing the external medicine bag;

[0019] Figure 4 It is a front view of an auxiliary fixation device for mouse external application drug experiment;

[0020] Figure 5 It is a side view of an auxiliary fixation device for mouse topical drug application experiments;

[0021] Figure 6 It is a top view of an auxiliary fixation device for mouse external application drug experiment;

[0022] Figure 7 The figure is a schematic diagram of the structure of the liquid collecting box of the auxiliary fixing device for mouse external application medicine experiment and the back of the experimental box;

[0023] Figure 8 The overall structural diagram of an experimental box of an auxiliary fixing device for mouse external application drug experiment;

[0024] Fig. 9 It is a schematic diagram of the structure of the fixing components of a mouse external application drug experiment auxiliary fixing device;

[0025] Fig.10 The invention is a cross-sectional schematic diagram of an adjusting knob in a fixing assembly of an auxiliary fixing device for a mouse external application drug experiment;

[0026] Fig.11 The present invention is a cross-sectional schematic diagram of a fixing clamp of an auxiliary fixing device for a mouse external application drug experiment.

[0027] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0028] 1-liquid collecting box, 11-liquid collecting box, 12-handle, 13-telescopic support rod, 14-movable groove, 2-experimental box, 21-through groove, 22-limiting block, 23-connecting line, 231-fixing clip, 2311-clamping handle, 2312-hollow cylinder, 2313-handle, 2314-U-shaped clip, 2315-cylindrical through hole, 24-connecting piece, 25-adjusting knob, 251-spring, 252-connecting column, 26-anti-slip pattern, 27-carrying frame, 271-grid, 28-feces collection plate, 281-through hole, 29-square groove, 3-drip tube, 31-connecting tube, 311-dressing patch, 4-external medicine bag, 41-hook, 42-liquid injection port, 43-flow rate switch, 44-flow guide tube, 5-rotating shaft. DETAILED DESCRIPTION

[0029] The utility model discloses an auxiliary fixing device for mouse external medicine application experiment, comprising a liquid collecting box 1, an experimental box 2, a liquid dropper, and an external medicine bag 4; the liquid collecting box 1 and the experimental box 2 are hollow structures, and the front ends are connected by a rotating shaft 5; through grooves 21 are opened at the upper ends of both sides of the experimental box 2, the liquid dropper is connected to the two ends of the through grooves 21 and extends outside the experimental box 2, and the position of the liquid dropper on the through groove 21 is adjusted by a fixing component arranged on the through groove 21; the external medicine bag 4 is connected to one end of the liquid dropper; the rear end of the liquid collecting box 1 is rotatably connected to a telescopic support rod 12; a square groove 29 is opened on the bottom side wall of the experimental box; the angle between the liquid collecting box 1 and the experimental box 2 is controlled by telescopically adjusting the relative position between the support rod and the square groove 29; Example

[0030] See also Figure 1-Figure 11In this embodiment, a square groove is opened at the front end of the liquid collecting box 1, and a liquid collecting box 11 is movably installed in the square groove; a handle 12 is set in the middle of the liquid collecting box 11; the liquid collecting box can slide in the square groove 29, and the urine of the mouse and the excess exuded liquid can be collected and processed through the liquid collecting box 11; after the experiment is completed, the liquid collecting box 11 is pulled out by the handle 12, and the collected liquid is sent to the designated location for processing; in this embodiment, a square groove is opened in the middle and lower part of the experimental box 2, and a feces collecting plate 28 is slidably installed in the square groove, and the feces collecting plate 28 has a linear array of through holes 281; the feces collecting A carrier 27 is fixedly mounted on the upper end of the tray 28, and a grid 271 is arranged in a linear array on the carrier 27; during the mouse experiment, urination and defecation may occur, and if they are not handled, the experimental table will inevitably be contaminated, so in this embodiment, a feces collection tray 28 is installed in the square groove 29 to collect the feces of the mice, and a carrier 27 is installed on the upper end of the feces collection tray 28, and the carrier 27 is mainly used to carry mice, and the carrier 27 is provided with a plurality of grids 271, so as to ensure that the excess liquid medicine and excrement can smoothly enter the feces collection tray 28 and the liquid collection box 11 below;

[0031] In summary, in this embodiment, the feces of the mice and the excess drug solution can be separated and collected to avoid contamination of the experimental table. Example

[0032] See also Figure 1-Figure 11 In this embodiment, the rear end of the liquid collecting box 1 is rotatably connected with a telescopic rod assembly on both sides, and a movable groove 14 is opened at the front end of the telescopic rod assembly; when the movable groove 14 is opened, it is to facilitate the movement of the telescopic rod assembly. In addition, a square groove 29 is opened on the bottom side wall of the experimental box, and the size of the square groove 29 is adapted to the size of the upper end rod of the telescopic rod assembly; when in use, the telescopic rod assembly is aligned with the square groove 29, and the angle between the experimental box 2 and the liquid collecting box 1 is controlled by the square grooves at different positions; when the telescopic rod assembly is gradually supported inward, the angle between the experimental box 2 and the liquid collecting box 1 is smaller; when the telescopic rod assembly is gradually supported outward, the angle between the experimental box 2 and the liquid collecting box 1 is larger; the experiment shows that when the angle between the experimental box 2 and the liquid collecting box 1 is maintained at 30° to 40°, the activity of the mice is minimal and relatively quiet, so it is best to control it at this angle. Example

[0033] See also Figure 1-Figure 11In this embodiment, the front end linear array of the dropper 3 has circular holes, and there is at least one circular hole on the dropper 3. A plurality of linear arrays can simultaneously perform external application experiments on multiple mice. The circular hole is connected to a connecting tube 31, and the front end of the connecting tube 31 is fixedly connected to a dressing patch 311; the liquid medicine is connected to the dressing patch 311 through the connecting tube 31 through the dropper 3; in this embodiment, the lower end of the external application bag 4 is connected to the dropper 3 through a guide tube 44, and a flow rate switch 43 is provided on the dropper 3; the upper end of the external application bag 4 A medicine injection port is opened at the end, and the upper end of the medicine injection port is connected to a hook 41; when in use, the medicine liquid is injected into the external medicine bag 4 through the medicine injection port, and the medicine liquid flows into the dropper 3 through the guide tube 44. The connecting tube 31 connected to the dropper 3 transports the medicine liquid to the dressing patch 311 for external application. At the same time, the flow rate switch 43 can control the flow rate of the medicine liquid to ensure that the medicine liquid can flow out evenly without causing waste. The flow rate switch 43 described in this embodiment is similar to the flow rate switch 43 on the Murphy-type dropper, which is a prior art and will not be explained in detail here.

[0034] In this embodiment, the front end linear array of the dropper 3 has circular holes, and the circular holes are connected to the connecting tube 31. The connection method can be achieved by using the existing pipeline connection technology, and when some circular holes are used, other unused circular holes can be closed, such as by tightening and sealing them with threaded caps. The closed form can be achieved by existing technology and will not be described in detail here. In addition, the front end of the connecting tube 31 is a forked pipe with a smaller diameter, which can be controlled by the flow rate switch 43 and the cooperation between the forked pipe, so that when it reaches the dressing 311, it can achieve gradual penetration in a smaller amount to achieve the desired effect. Example

[0035] See also Figure 1-Figure 11 In this embodiment, a connecting line 23 is provided at the rear side of the upper end of the experimental box 2, and a fixing clip 231 is connected to the front end of the connecting line 23; there is at least one connecting line 23, and there is also at least one fixing clip 231 corresponding to the connecting line 23; the specific structural principle of the fixing clip 231 is as follows Fig.11As shown, the fixing clip 231 includes a dovetail clip and a tail fixing clip 231, the tail fixing clip 231 is fixedly installed on one side of the upper end of the dovetail clip, and the line segment of the dovetail clip is an arc structure; the tail fixing clip 231 includes a hollow cylinder 2312 and a handle 2313, the handle 2313 is movably installed in the middle of the hollow cylinder 2312, a cylindrical through hole 2315 is opened at the front end, a spring 251 is arranged at the front end of the handle 2313, and a U-shaped clip 2314 is installed at the front end of the spring 251; when the mouse needs to be fixed, the fixing clip 231 is first clamped into the grid 271, and since the front end of the dovetail clip is an arc structure, it can be ensured that the dovetail clip can It is firmly installed on the grid 271; when fixing the mouse's tail, first, pull the handle 2313, the handle 2313 drives the spring 251 to move upward, the spring 251 drives the U-shaped clip 2314 to move upward, and after being pulled up, the mouse's tail passes through the cylindrical through hole 2315, and then release the handle 2313. Under the action of the spring 251, the U-shaped clip 2314 moves downward to fix the mouse's tail; in this embodiment, in order to ensure that the mouse's tail will not be damaged during fixation, the U-shaped clip 2314 is made of silicone; in addition, the clamping handle 2311 of the dovetail clip in this embodiment is a prior art and will not be described in detail here. Example

[0036] See also Figure 1-Figure 11 In this embodiment, the fixing assembly includes a connecting member 24 and an adjusting knob; holes are opened at both ends of the connecting member 24, one end is connected to the drip tube 3, and the other end is connected to the adjusting knob; the specific structure is as follows Fig. 9 As shown, when in use, the adjusting knob is pulled, and then the dropper 3 is driven to move downward to achieve the function of adjusting the position; the specific structure of the adjusting knob is as shown in Fig.10 As shown, the specific principle is: when the adjusting knob is pulled, the spring 251 is compressed under the action of the pulling force, the adjusting knob moves upward, and the pressure on the connecting member 24 is lost, so it can be moved; after adjusting to a suitable position, the adjusting knob is released, and under the action of the spring 251, the adjusting knob moves downward to support the connecting member 24 to complete the fixation.

[0037] The use process of the utility model is as follows: first, the experimental box 2 is adjusted to a corresponding angle according to the experimental needs; when in use, the hair on the back of the mouse is shaved with an electric shaver to a size of about 2 cm by 3 cm, and then the mouse is fixed by its tail on the supporting frame 27 through the fixing clip 231; then the liquid medicine is injected through the injection port of the external compress bag 4, and when the Chinese medicine decoction or the western medicine solution soaks the dressing, the height of the dropper 3 is adjusted to be perpendicular to the proximal end of the gauze dressing on the back of the mouse and applied to the back of the mouse; then the flow rate switch 43 is adjusted according to the experimental needs, and the appropriate flow rate is adjusted, and the Chinese medicine decoction or the western medicine solution is transferred to the gauze dressing on the small back through the drip hole to keep the gauze dressing moist during the experiment, and the excess liquid medicine is collected through the liquid collection box 11.

[0038] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the present invention to the specific implementation methods described.

Claims

1. A mouse external application drug experiment auxiliary fixation device, characterized in that: include: Liquid collection box, experimental box, dropper, external application bag; The liquid collecting box and the experimental box are hollow structures, and the front ends are connected by a rotating shaft; through grooves are opened at the upper ends of both sides of the experimental box, and the drip tube is connected to the two ends of the through groove and extends out of the experimental box and the position of the drip tube on the through groove is adjusted by a fixing component arranged on the through groove; the external application medicine bag is connected to one end of the drip tube; the rear end of the liquid collecting box is rotatably connected to the telescopic support rod; a square groove is opened on the bottom side wall of the experimental box; the angle between the liquid collecting box and the experimental box is controlled by telescopically adjusting the relative position between the support rod and the square groove.

2. The auxiliary fixation device for mouse external application drug experiment according to claim 1, characterized in that: A square groove is formed at the front end of the liquid collecting box, and a liquid collecting box is movably installed in the square groove; a handle is arranged in the middle of the liquid collecting box.

3. The auxiliary fixation device for mouse external application experiment according to claim 2, characterized in that: Both sides of the rear end of the liquid collecting box are rotatably connected with telescopic rod components, and the front end of the telescopic rod component is provided with a movable groove.

4. The auxiliary fixation device for mouse external application drug experiment according to claim 1, characterized in that: A square groove is provided in the middle and lower part of the experimental box, a feces collecting plate is slidably installed in the square groove, and the feces collecting plate has through holes in a linear array; a supporting frame is fixedly installed on the upper end of the feces collecting plate, and a grid is provided in a linear array on the supporting frame.

5. The auxiliary fixation device for mouse external application drug experiment according to claim 1, characterized in that: The front end of the dropper tube is provided with a linear array of circular holes, the circular holes are connected with connecting tubes, and the front end of the connecting tubes is fixedly connected to the dressing patch.

6. The auxiliary fixation device for mouse external application drug experiment according to claim 1, characterized in that: A connecting line is arranged at the rear side of the upper end of the experimental box, and a fixing clip is connected to the front end of the connecting line.

7. The auxiliary fixation device for mouse external application drug experiment according to claim 1, characterized in that: The lower end of the external medicine bag is connected to the dripping tube through a guide tube, and a flow rate switch is arranged on the dripping tube; the upper end of the external medicine bag is provided with a medicine injection port, and the upper end of the medicine injection port is connected with a hook.

8. The auxiliary fixation device for mouse external application drug experiment according to claim 1, characterized in that: The fixing assembly comprises a connecting piece and an adjusting knob; holes are opened at both ends of the connecting piece, one end is connected to the drip tube, and the other end is connected to the adjusting knob.

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