Continuous and rapid liposome preparation equipment
By designing the continuous and rapid liposome preparation equipment including raw material tanks, preparation tanks and heat exchangers, the problems of low preparation efficiency and high human intervention in existing equipment are solved, and continuous rapid production and automated production of high-quality products are achieved.
Patent Information
- Application Number
- CN202420651765.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-01
- Publication Date
- 2024-12-20
- Estimated Expiration
- 2034-04-01
AI Technical Summary
The existing liposome preparation equipment has low preparation efficiency and errors in the injection method. It is impossible to achieve continuous and rapid production during large-scale production, and has high human intervention, making it difficult to control the ratio of the aqueous phase to the oil phase, and it takes a long time.
A continuous and rapid preparation equipment for liposomes including raw material tanks, preparation tanks, heat exchangers and pipes was designed. The raw materials were preheated by heat exchangers to achieve continuous production, and through high thermal conductivity pipes and high thermal insulation materials. Design to reduce heat energy consumption and labor costs.
The continuous and rapid preparation of liposomes is achieved, product quality is ensured, automatic production is achieved, thermal energy consumption and labor costs are reduced, and the control of the proportion of water and oil is simplified.
Smart Images
Figure CN222196938U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of chemical equipment, and in particular relates to a liposome continuous and rapid preparation device. Background Art
[0002] The raw materials for preparing liposomes include an aqueous phase and an oil phase. Generally speaking, the oil phase is phospholipids. The aqueous phase and the oil phase need to be stirred at the phospholipid transition temperature (45°C-55°C) so that the phospholipids self-assemble into a double-layer membrane structure in the aqueous phase.
[0003] Existing liposome preparation equipment usually uses a syringe to manually inject the oil phase into the water phase at a uniform speed when preparing liposomes by the injection method. Injecting the oil phase in this way not only requires constant attention to the injection amount of the oil phase, but is also time-consuming and labor-intensive, has low preparation efficiency, and has large errors, which can easily lead to poor quality of the solution after the reaction.
[0004] In large-scale production, mechanized means are often used to pump the water phase and oil phase raw materials into the reactor for preparation. After the preparation is completed, the reactor is opened to release the product, and then the next batch of preparation is carried out. Continuous and rapid production cannot be achieved. Although mechanized, the degree of human intervention is very high. In particular, when controlling the ratio of water phase and oil phase, it is necessary to adjust the parameters of the two pumps for inputting water phase raw materials and oil phase raw materials. In addition, the temperature needs to be increased for each preparation, which takes a long time.
[0005] Therefore, there is an urgent need to develop a continuous production, rapid liposome preparation device. Utility Model Content
[0006] The purpose of the utility model is to provide a liposome continuous and rapid preparation device in view of the defects and shortcomings of the prior art. Through structural improvements and the addition of structural designs such as heat exchangers, continuous production and rapid preparation are achieved, and the quality of liposome products can be guaranteed.
[0007] On the one hand, the utility model provides a liposome preparation device, including a raw material tank, a preparation tank, a heat exchanger and a pipeline, the pipeline including a raw material pipeline, a product pipeline and a feed pipeline, the raw material pipeline connects the raw material tank and the heat exchanger, the product pipeline connects the preparation tank and the heat exchanger, and the feed pipeline connects the heat exchanger and the preparation tank; the raw material is transported from the raw material tank to the heat exchanger through the raw material pipeline, the product is transported from the preparation tank to the heat exchanger through the product pipeline, the heat exchanger connects the feed pipeline and the product pipeline, the raw material is preheated using the temperature of the product, and the preheated raw material is transported to the preparation tank through the feed pipeline.
[0008] Furthermore, the heat exchanger is a hollow cylindrical device, including a tube side and a shell side. The tube side is the pipe inside the heat exchanger, and the shell side is the space inside the heat exchanger. The tube side and the shell side are not connected to each other; the product is in the shell side, and the raw material is in the tube side, and the heat is transferred from the product to the raw material through the tube wall of the tube side.
[0009] Furthermore, the pipe material of the tube side is a material with high thermal conductivity, and the material of the heat exchanger is a material with high thermal insulation.
[0010] Furthermore, an air hole is left above the preparation tank, and the pipeline also includes a collecting pipeline, one end of the collecting pipeline is connected to the heat exchanger, and the other end is connected to the vacuum pump; except for the preparation tank and the collecting pipeline, other parts of the liposome preparation equipment have good air tightness.
[0011] Furthermore, the heat exchanger is placed vertically, and the liquid in the tube side and the shell side flows from bottom to top under the action of the vacuum pump.
[0012] Furthermore, the preparation tank includes a preparation tank body, and the preparation tank body is an integrally formed cylindrical device, the upper part of which is a cylindrical structure and the lower part of which is a funnel-shaped structure.
[0013] Furthermore, the preparation tank includes a heating kit, which is a cylindrical jacket. The heating kit covers the cylindrical structure on the upper part of the preparation tank, and the temperature of the heating kit is set to 55°C.
[0014] Furthermore, the feed pipeline connects the tube side of the heat exchanger and the preparation tank, and the temperature of the raw materials in the feed pipeline is higher than 45°C.
[0015] Furthermore, the preparation tank comprises a preparation tank cover, which covers the top of the preparation tank, and a motor is arranged on the preparation tank cover.
[0016] Furthermore, the preparation tank includes a stirring rod, which is connected to a motor. The stirring rod is a long rod with stirring blades, and the motor drives the stirring rod to rotate.
[0017] The beneficial effects of the utility model include:
[0018] 1. Provided is a liposome continuous and rapid preparation device, which realizes continuous production and rapid preparation through structural improvement, and can ensure the quality of liposome products;
[0019] 2. By using the design of the heat exchanger, the product is used to preheat the raw materials so that the raw materials reach the required temperature for liposome preparation in advance. When entering the preparation tank, the quality of the liposome will not be affected by the sudden drop in temperature, and the heat energy and the time required for heating are saved, thus realizing continuous automated production;
[0020] 3. The integrated design allows the entire preparation process to be completed using only one pump. The different mixing ratios of the water phase and the oil phase can be controlled by adjusting parameters such as the friction of the inner wall of the pipeline and the inner diameter of the pipeline, or by introducing a throttle valve for flexible control, saving labor costs. BRIEF DESCRIPTION OF THE DRAWINGS
[0021] Figure 1 :Liposome continuous rapid preparation equipment
[0022] Figure 2 :Bottom view of liposome continuous rapid preparation equipment
[0023] Figure 3 : Preparation tank
[0024] Figure 4 : View from below of the preparation tank
[0025] Figure 5 : Preparation tank cross-section view
[0026] Figure 6 :Heat Exchanger
[0027] Figure 7 : Heat exchanger cross-section view DETAILED DESCRIPTION
[0028] The utility model is further described below in conjunction with the accompanying drawings and embodiments. It should be pointed out that the embodiments are only a detailed description of the utility model and cannot be used to limit the protection scope of the utility model. All features disclosed in the embodiments of the utility model, or steps in all methods or processes disclosed, except for mutually exclusive features and / or steps, can be combined in any way and are within the protection scope of the utility model. Any changes made by ordinary technicians in this field according to the technical ideas of the utility model without making creative work should be within the protection scope of the utility model. Technologies not covered by the utility model can be implemented by existing technologies.
[0029] Example 1: Liposome continuous rapid preparation device
[0030] Figure 1 The utility model is a continuous and rapid liposome preparation device, comprising a raw material tank 1, a pipeline 2, a heat exchanger 3, and a preparation tank 4, wherein the raw material tank 1 comprises an aqueous phase raw material tank 11 and an oil phase raw material tank 12, which respectively store aqueous phase raw materials and oil phase raw materials for preparing liposomes. An air hole is reserved at the top of the raw material tank 1. Except for the raw material tank 1 and the collection pipeline 24 mentioned later, the continuous and rapid liposome preparation device has good air tightness.
[0031] The pipeline 2 includes a raw material pipeline 21, a feed pipeline 22, a product pipeline 23, and a collection pipeline 24. The raw material pipeline 21 connects the raw material tank 11 and the heat exchanger 3, the feed pipeline 22 connects the heat exchanger 3 and the preparation tank 4, the product pipeline 23 connects the preparation tank 4 and the heat exchanger 3, one end of the collection pipeline 24 is connected to the heat exchanger 3, and the other end is connected to the subsequent collection equipment. The collection pipeline 24 can be connected to a vacuum pump to apply negative pressure to the liposome continuous and rapid preparation equipment. Only one vacuum pump needs to be connected to make the liquid inside the equipment flow according to the preparation process requirements.
[0032] In order to control the mixing ratio of different raw materials under one vacuum pump, parameters such as the pipe diameter and the roughness of the inner wall of the pipe can be adjusted to achieve different flow rates under the same negative pressure; or a throttle valve can be set in the feed pipe 21.
[0033] like Figure 1 and Figure 2 According to the different types of raw materials transported inside, the raw material pipeline 21 and the feed pipeline 22 are divided into a water phase raw material pipeline 211 and an oil phase raw material pipeline 212, and the feed pipeline 22 is divided into a water phase feed pipeline 221 and an oil phase feed pipeline 222.
[0034] Figure 3 It is a preparation tank in the liposome continuous rapid preparation equipment. Figure 4 To prepare a bottom view of the tank, Figure 5 It is a cross-sectional view of the preparation tank, wherein the preparation tank 4 comprises a preparation tank cover 41, a preparation tank body 42, and a heating jacket 43. A feed port 411 is provided on the preparation tank cover 41, and the feed port 411 is divided into a water phase feed port 4111 and an oil phase feed port 4112 according to the type of feed raw materials, and are respectively connected to a water phase feed pipeline 221 and an oil phase feed pipeline 222, so that the two raw materials can enter the interior of the preparation tank 4.
[0035] The preparation tank body 42 is integrally formed, with a cylindrical structure at the top and a funnel-shaped structure at the bottom. The heating jacket 43 surrounds the cylindrical portion of the preparation tank body 42. Below the preparation tank body 42 is an extrusion port 421 for extruding the prepared liposomes.
[0036] The preparation tank 4 also includes a motor 412 and a stirring rod 413. The motor 412 is fixed on the preparation tank cover 41. The stirring rod 413 is a rod with stirring blades, which is vertically placed inside the preparation tank 4 and connected to the motor at one end. The stirring rod 413 rotates, and its stirring blades can stir the liquid. The motor 412 is connected to the stirring rod 413, and the motor 412 drives the stirring rod 413 to rotate to stir the liquid inside the preparation tank 4.
[0037] Figure 6 It is a heat exchanger in the equipment for continuous and rapid preparation of liposomes. Figure 7 It is a cross-sectional view of the heat exchanger, and the heat exchanger 3 includes a raw material feed port 31, a raw material discharge port 32, a product feed port 33, and a product discharge port 34. The raw material feed port 31 is connected to the raw material pipeline 21, and is divided into a water phase raw material feed port 311 and an oil phase raw material feed port 312 according to different raw materials. The raw material discharge port 32 is connected to the feed pipeline 22, and is also divided into a water phase raw material discharge port 321 and an oil phase raw material discharge port 322 according to different raw materials.
[0038] The interior of the heat exchanger 3 includes a tube side 35 and a shell side 36. The tube side 35 is a pipeline inside the heat exchanger 3 and connected to the raw material feed port 31 and the raw material discharge port 32. It is also divided into a water phase raw material tube side 351 and an oil phase raw material tube side 352 according to different raw materials. The pipe material of the tube side 35 has high thermal conductivity; the shell side 36 is the interior of the heat exchanger 3, connected to the product feed port 33 and the product discharge port 34, and the outer shell material of the heat exchanger 3 has high thermal insulation.
[0039] Example 2: Preparation of liposomes using a liposome continuous rapid preparation device
[0040] Based on the liposome continuous rapid preparation device described in Example 1, this example describes the use of the device. First, sufficient amounts of water phase raw materials and oil phase raw materials are added to the water phase raw material tank 11 and the oil phase raw material tank 12, respectively. Since the liposome continuous rapid preparation device has good air tightness except for the raw material tank 1 and the collection pipe 24 mentioned later, a vacuum pump is connected behind the collection pipe 24, and fully automatic continuous production can be achieved under negative pressure drive.
[0041] The suitable temperature for liposome production is 45°C-55°C, so during production, the heating jacket 43 is first opened and the heating temperature is set to 55°C to provide the preparation tank 4 with a suitable production temperature.
[0042] At a certain moment of continuous automatic production, the water phase raw material and the oil phase raw material enter the heat exchanger 3 along the water phase raw material pipeline 211 and the oil phase raw material pipeline 212 respectively, and enter the water phase raw material tube side 351 and the oil phase raw material tube side 352 respectively. Due to the negative pressure drive, the product also enters the heat exchanger 3 along the product pipeline 23 and enters the shell side 36. Since the tube side 35 has high thermal conductivity, the temperature of the finished product (slightly lower than 55°C) can conduct heat to the raw material. For example, through the design of the present invention or other suitable designs, the temperature of the raw material can be between 45°C and 55°C when it leaves the heat exchanger 3. At this time, when the raw material enters the preparation tank 4 again, it is ensured that its temperature meets the temperature required for liposome production.
[0043] In the preparation tank 4, the motor 412 continuously drives the stirring rod 413 to rotate. The centrifugal force of the liquid causes the liquid inside the preparation tank 4 to continuously contact the preparation tank body 42. The heating jacket 43 is tightly attached to the preparation tank body 42, providing a heating temperature of 55°C, so that the liquid inside the preparation tank 4 can be heated evenly.
[0044] The extrusion port 421 at the bottom of the preparation tank 4 is provided with a filter screen with a certain pore size to filter the liposomes that meet the requirements. This part of the liquid becomes the product, leaves from the extrusion port 421, is transported to the heat exchanger 3 through the product pipeline 23, and conducts heat to the raw materials in the pipe 35. The product and the raw material move from bottom to top. At the upper end of the heat exchanger 3, the temperature of the product and the raw material tends to be consistent, both slightly higher than 45°C. At this time, the product leaves the heat exchanger 3 through the collection channel 24 and is subsequently collected.
Claims
1. A liposome continuous rapid preparation device, characterized in that: It includes a raw material tank, a preparation tank, a heat exchanger and a pipeline. The pipeline includes a raw material pipeline, a product pipeline and a feed pipeline. The raw material pipeline connects the raw material tank and the heat exchanger, the product pipeline connects the preparation tank and the heat exchanger, and the feed pipeline connects the heat exchanger and the preparation tank. The raw material is transported from the raw material tank to the heat exchanger through the raw material pipeline, and the product is transported from the preparation tank to the heat exchanger through the product pipeline. The heat exchanger connects the feed pipeline and the product pipeline. The raw material is preheated by utilizing the temperature of the product, and the preheated raw material is transported to the preparation tank through the feed pipeline.
2. The liposome continuous rapid preparation device as claimed in claim 1, characterized in that: The heat exchanger is a hollow cylindrical device, including a tube side and a shell side. The tube side is the pipe inside the heat exchanger, and the shell side is the space inside the heat exchanger. The tube side and the shell side are not connected to each other. The product is in the shell side, and the raw material is in the tube side. The heat is transferred from the product to the raw material through the tube wall of the tube side.
3. The liposome continuous rapid preparation device as claimed in claim 2, characterized in that: The pipe material of the tube side is a material with high thermal conductivity, and the material of the heat exchanger is a material with high thermal insulation.
4. The liposome continuous rapid preparation device as claimed in claim 3, characterized in that: An air hole is left above the preparation tank, and the pipeline also includes a collecting pipeline, one end of the collecting pipeline is connected to the heat exchanger, and the other end is connected to the vacuum pump; except for the preparation tank and the collecting pipeline, other parts of the liposome preparation equipment have good air tightness.
5. The liposome continuous rapid preparation device as claimed in claim 4, characterized in that: The heat exchanger is placed vertically, and the liquid in the tube side and shell side flows from bottom to top under the action of the vacuum pump.
6. The liposome continuous rapid preparation device as claimed in claim 5, characterized in that: The preparation tank comprises a preparation tank body, which is an integrally formed cylindrical device, the upper part of which is a cylindrical structure and the lower part of which is a funnel-shaped structure.
7. The liposome continuous rapid preparation device as claimed in claim 6, characterized in that: The preparation tank includes a heating kit, which is a cylindrical jacket. The heating kit covers the cylindrical structure on the upper part of the preparation tank. The temperature of the heating kit is set to 55°C.
8. The liposome continuous rapid preparation device as claimed in claim 7, characterized in that: The feed pipeline connects the tube side of the heat exchanger and the preparation tank, and the temperature of the raw materials in the feed pipeline is higher than 45°C.
9. The liposome continuous rapid preparation device as claimed in claim 8, characterized in that: The preparation tank comprises a preparation tank cover, which covers the top of the preparation tank and is provided with a motor.
10. The liposome continuous rapid preparation device according to claim 9, characterized in that: The preparation tank comprises a stirring rod, which is connected to a motor. The stirring rod is a long rod with stirring blades, and the motor drives the stirring rod to rotate.