Device for uniformly mixing reagent and sample

Abstract

The utility model relates to the technical field of medical instruments, in particular to a device for uniformly mixing a reagent and a sample, which acts on a sample cup with a magnetic steel ball and comprises a cup grabbing mechanism and a uniform mixing mechanism, and the magnetic steel ball in the sample cup annularly moves in the sample cup to uniformly mix a mixed solution of the reagent and the sample in the sample cup. The uniformly-mixed liquid is uniform, the uniformly-mixing time is relatively short, the sample test requirement is met, the pollution probability of an external uniformly-mixing device to the sample is reduced, the test speed and the analysis stability and accuracy are improved, and the problem that in the existing sample analysis process, due to the fact that the mixed liquid of the sample and the reagent is not uniformly mixed, the uniformly-mixing effect is poor is solved. The technical problems that in the prior art, a sample and a reagent are obviously layered up and down in a sample cup, so that the reaction is unstable, and long time needs to be spent for uniformly mixing in order to meet the detection requirement are solved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a device for mixing reagents and samples. Background Art

[0002] In medical device sample analysis instruments, a uniform and stable mixture of reagents and samples is required in advance to improve detection efficiency and obtain reliable test results. Based on this requirement, a device for mixing reagents and samples is an indispensable component of the analysis instrument. The purpose of sample mixing is to allow the sample and reagent to form a uniform mixture that meets the analysis requirements in the sample cup in a relatively short time, thereby providing stable and controllable reaction conditions for subsequent sample analysis.

[0003] There are three main mixing methods commonly used at present: the first is to use a sample suction syringe to stir and mix in the reaction cup and then cooperate with the sample syringe's pumping and drainage function to mix, which requires the use of a liquid circuit; the second is to install a vibration motor on the clamp, and after the clamp grasps the cup, the high-speed vibration of the vibration motor is used to drive the sample cup to vibrate to achieve the mixing function. It is suitable for round cups, and the mixing effect of other shapes of sample cups is average; the third is to use a stirring rod to extend into the sample cup, and use the motor to drive the stirring rod to mix. This method is prone to carry contamination or cross-contamination, and the stirring rod needs to be cleaned every time, affecting efficiency.

[0004] During the sample analysis process, it is often the case that the sample and reagent mixture is not mixed evenly or the mixing effect is poor, resulting in obvious stratification of the sample and reagent in the sample cup, which leads to unstable reaction. In order to meet the detection requirements, it takes a long time to mix. At the same time, small bubbles will be generated in the mixed solution after mixing, which will affect the accuracy of the test results. Utility Model Content

[0005] The purpose of the utility model is to provide a device for mixing reagents and samples, which solves the problem that in the existing sample analysis process, the mixed solution of the sample and the reagent is not mixed evenly and the mixing effect is poor, so that the sample and the reagent are obviously stratified up and down in the sample cup, which leads to unstable reaction. In order to meet the detection requirements, it takes a long time to mix.

[0006] To achieve the above-mentioned purpose, the utility model provides a device for mixing reagents and samples, which acts on a sample cup with a magnetic steel ball, and includes a cup grabbing mechanism and a mixing mechanism. The cup grabbing mechanism is used to grab the sample cup, and the mixing mechanism is used to mix the mixed liquid of the reagent and the sample in the sample cup; the mixing mechanism includes a motor mounting frame, a mixing motor, a mixing eccentric wheel and a permanent magnet. The mixing motor is mounted on the motor mounting frame, the mixing eccentric wheel is mounted on the output shaft of the mixing motor, and the permanent magnet is mounted in a hole on the mixing eccentric wheel. There is a certain eccentric distance between the permanent magnet and the output shaft of the mixing motor in the radial direction. The permanent magnet is driven to move by the driving of the mixing motor, so that the permanent magnet adsorbs the magnetic steel ball and drives the magnetic steel ball to move in a ring in the sample cup, thereby achieving mixing of the mixed liquid of the reagent and the sample in the sample cup.

[0007] When the permanent magnet drives the magnetic steel ball to perform circular motion to the highest point, the magnetic steel ball should still be located below the mouth of the sample cup, so as to prevent the magnetic steel ball from falling out of the sample cup during circular motion.

[0008] Wherein, the mixing mechanism further comprises a mixing mounting frame and a mixing adjustment block, wherein the mixing mounting frame is mounted below the motor mounting frame; and the mixing adjustment block is mounted on the mixing mounting frame.

[0009] Wherein, when the mixed solution of the reagent and the sample in the sample cup is mixed, the distance between the sample cup and the permanent magnet is maintained within the range of 3 to 5 mm.

[0010] The cup grabbing mechanism comprises a driving block and a cup grabbing hand, wherein the driving block is used to drive the cup grabbing hand to move along the X-axis or the Y-axis, and the cup grabbing hand is used to grab the sample cup.

[0011] The driving block includes an X-axis driving motor, an X-axis guide rail, an X-axis slider, a Y-axis driving motor, a Y-axis guide rail and a Y-axis slider. The cup gripper moves along the X-axis by using the X-axis driving motor, the X-axis guide rail and the X-axis slider in cooperation; the cup gripper moves along the Y-axis by using the Y-axis driving motor, the Y-axis guide rail and the Y-axis slider in cooperation.

[0012] The utility model discloses a device for mixing reagents and samples. The utility model realizes mixing of the mixed solution of the reagent and the sample in the sample cup by the magnetic steel ball in the sample cup making a circular motion in the sample cup. After mixing, the mixed solution is uniform and the mixing time is short, which meets the sample testing requirements, reduces the probability of contamination of the sample by an external mixing device, improves the testing speed, the stability and the accuracy of the analysis, and solves the problem that in the existing sample analysis process, the mixed solution of the sample and the reagent is not mixed uniformly and the mixing effect is not good, so that the sample and the reagent are obviously stratified in the sample cup, which leads to unstable reaction. In order to meet the detection requirements, it takes a long time to mix. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art are briefly introduced below.

[0014] Figure 1 It is a schematic diagram of the overall structure of the device for mixing reagents and samples according to the first embodiment of the utility model.

[0015] Figure 2 It is a structural schematic diagram of a sample cup according to the first embodiment of the utility model.

[0016] Figure 3 It is a structural schematic diagram of the mixing mechanism of the first embodiment of the utility model.

[0017] Figure 4 It is a structural explosion diagram of the mixing mechanism of the first embodiment of the utility model.

[0018] Figure 5 It is a front view of the sample mixing position of the first embodiment of the utility model.

[0019] Figure 6 It is a side view of the sample mixing position of the first embodiment of the utility model.

[0020] Figure 7 It is a schematic diagram of the movement trajectory of the magnetic steel ball when mixing in the sample cup of the first embodiment of the utility model.

[0021] In the figure: 101-magnetic steel ball, 102-sample cup, 103-motor mounting bracket, 104-mixing motor, 105-mixing eccentric wheel, 106-permanent magnet, 107-mixing mounting bracket, 108-mixing adjustment block, 109-cup gripper, 110-X-axis drive motor, 111-X-axis guide rail, 112-X-axis slider, 113-Y-axis drive motor, 114-Y-axis guide rail, 115-Y-axis slider. DETAILED DESCRIPTION

[0022] Embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, but should not be understood as limiting the present invention.

[0023] First embodiment:

[0024] See also Figures 1 to 7 ,in Figure 1 It is a schematic diagram of the overall structure of the device for mixing reagents and samples according to the first embodiment of the utility model. Figure 2 1 is a schematic diagram of the structure of the sample cup 102 of the first embodiment of the utility model. Figure 3 It is a structural schematic diagram of the mixing mechanism of the first embodiment of the utility model. Figure 4 This is an exploded view of the structure of the mixing mechanism of the first embodiment of the utility model. Figure 5 1 is a front view of the sample mixing position of the first embodiment of the utility model. Figure 6 1 is a side view of the sample mixing position of the first embodiment of the utility model. Figure 7 It is a schematic diagram of the motion trajectory of the magnetic steel ball 101 when mixing in the sample cup 102 of the first embodiment of the utility model. The utility model provides a device for mixing reagents and samples, which acts on the sample cup 102 with the magnetic steel ball 101, including a cup grabbing mechanism and a mixing mechanism. The mixing mechanism includes a motor mounting frame 103, a mixing motor 104, a mixing eccentric wheel 105, a permanent magnet 106, a mixing mounting frame 107 and a mixing adjustment block 108. The cup grabbing mechanism includes a driving block and a cup grabbing hand 109. The driving block includes an X-axis driving motor 110, an X-axis guide rail 111, an X-axis slider 112, a Y-axis driving motor 113, a Y-axis guide rail 114 and a Y-axis slider 115.

[0025] In this embodiment, the utility model achieves mixing of the mixed solution of the reagent and the sample in the sample cup 102 by the magnetic steel ball 101 in the sample cup 102 making a circular motion in the sample cup 102. After mixing, the mixed solution is uniform and the mixing time is short, which meets the sample testing requirements, reduces the probability of contamination of the sample by the external mixing device, improves the test speed, and improves the stability and accuracy of the analysis. It solves the problem that during the analysis of existing samples, the mixed solution of the sample and the reagent is not mixed uniformly, resulting in poor mixing effect, resulting in obvious upper and lower stratification of the sample and the reagent in the sample cup 102, which leads to unstable reaction. In order to meet the detection requirements, it takes a long time to mix.

[0026] Among them, the cup grabbing mechanism is used to grab the sample cup 102, and the mixing mechanism is used to mix the mixed liquid of the reagent and the sample in the sample cup 102. The mixing motor 104 is installed on the motor mounting frame 103, and the mixing eccentric wheel 105 is installed on the output shaft of the mixing motor 104. The permanent magnet 106 is installed in the hole on the mixing eccentric wheel 105. There is a certain eccentric distance between the permanent magnet 106 and the output shaft of the mixing motor 104 in the radial direction. The permanent magnet 106 is driven by the mixing motor 104 to move, so that the permanent magnet 106 adsorbs the magnetic steel ball 101 and drives the magnetic steel ball 101 to move in a circle in the sample cup 102, so as to achieve mixing of the mixed liquid of the reagent and the sample in the sample cup 102.

[0027] Secondly, when the permanent magnet 106 drives the magnetic steel ball 101 to perform circular motion to the highest point, the magnetic steel ball 101 should still be located below the mouth of the sample cup 102, so that the magnetic steel ball 101 does not fall out of the sample cup 102 during circular motion.

[0028] Again, the mixing mounting frame 107 is installed below the motor mounting frame 103; the mixing adjustment block 108 is installed on the mixing mounting frame 107, the mixing adjustment block 108 is made of plastic material, and three positions of the mixing adjustment block 108 are provided with inclined surfaces.

[0029] Meanwhile, when the mixed solution of the reagent and the sample in the sample cup 102 is mixed, the distance between the sample cup 102 and the permanent magnet 106 is maintained within a range of 3 to 5 mm.

[0030] In addition, the driving block is used to drive the cup gripper 109 to move along the X-axis or the Y-axis, and the cup gripper 109 is used to grip the sample cup 102 .

[0031] Finally, the cup gripper 109 is moved along the X-axis by the cooperation of the X-axis driving motor 110, the X-axis guide rail 111 and the X-axis slider 112; and the cup gripper 109 is moved along the Y-axis by the cooperation of the Y-axis driving motor 113, the Y-axis guide rail 114 and the Y-axis slider 115.

[0032] When using a device for mixing reagents and samples of the present embodiment, when it is necessary to mix the reagents and samples in the sample cup 102, first obtain the mixing parameters of the sample, then assemble the cup grabbing mechanism and the mixing mechanism together, and then let the cup grabbing hand 109 grab the sample cup 102. After grabbing, start the X-axis drive motor 110 so that the power output from the output end of the X-axis drive motor 110 drives the X-axis slider 112 to move along the X-axis outside the X-axis guide rail 111, thereby driving the cup grabbing hand 109 to move along the X-axis, and start the Y-axis drive motor 113 so that the power output from the output end of the Y-axis drive motor 113 drives the Y-axis slider 115 to move along the Y-axis outside the Y-axis guide rail 114. The sample cup 102 is moved to the sample mixing position of the mixing mechanism. When the sample cup 102 is moved to the sample mixing position, the mixing motor 104 is started and stopped according to the mixing parameters of the sample. When the mixing motor 104 is started, the power output from the output end of the mixing motor 104 can drive the permanent magnet 106 to move, thereby driving the permanent magnet 106 to adsorb the magnetic steel ball 101 in the sample cup 102 and gradually drive the magnetic steel ball 101 to perform a circular motion in the sample cup 102, thereby achieving mixing of the mixed solution of the reagent and the sample in the sample cup 102.

[0033] The sample cup 102 containing the sample is grabbed by the cup grabbing mechanism to the sample mixing position of the mixing mechanism, so that the permanent magnet 106 can effectively adsorb the magnetic steel ball 101 in the sample cup 102 and drive the magnetic steel ball 101 to move to a suitable distance, so that the magnetic steel ball 101 will perform a circular operation in the sample cup 102 to achieve mixing of the reagent and sample in the sample cup 102. It is worth noting that when the permanent magnet 106 drives the magnetic steel ball 101 to perform a circular operation to the highest point, the magnetic steel ball 101 should still be below the cup mouth of the sample cup 102, so as to achieve the purpose of preventing the magnetic steel ball 101 from falling out of the sample cup 102 during the circular operation.

[0034] When the cup-grabbing mechanism clamps the sample cup 102 to the mixing mechanism, a mixing adjustment block 108 is provided at the sample mixing position of the mixing mechanism. The mixing adjustment block 108 is made of plastic material, and three positions of the adjustment block are provided with inclined surfaces, so that the sample cup 102 can be guided when the cup-grabbing mechanism moves the sample cup 102 to the sample mixing position, thereby preventing the risk of the sample cup 102 colliding with the mixing mechanism, and avoiding the position of the sample cup 102 on the cup-grabbing mechanism being tilted (not vertical) due to excessive suction of the permanent magnet 106, thereby affecting the analysis accuracy of the sample in the sample cup 102 after mixing. Since no foreign objects are added to mix in the sample cup 102 during the whole mixing process, the probability of sample contamination can be reduced.

[0035] The installation method of the mixing mechanism is as follows: the mixing motor 104 is fixed to the motor mounting frame 103 by 4 screws, the permanent magnet 106 is placed in the hole on the mixing eccentric wheel 105, and is fixed by glue (such as 5011 or 502 quick-drying glue, etc.), the mixing eccentric wheel 105 is fixed to the output shaft of the mixing motor 104 by a set screw, and then the motor mounting frame 103 is fixed to the mixing mounting frame 107 by 2 screws, and finally the mixing adjustment block 108 is fixed to the mixing mounting frame 107 by 2 screws, thereby completing the assembly of the components of the entire mixing mechanism.

[0036] After assembling the components of the mixing mechanism itself, the two mounting waist holes on the mixing mechanism are used to fix it on the mounting fixing plate of the mixing mechanism. The cup grabbing mechanism is provided with a driving motor and a corresponding guide rail slider in the X and Y directions respectively, so that the cup grabbing hand 109 on the cup grabbing mechanism can move along the X and Y directions, so that the sample cup 102 can be transferred to the sample mixing position of the mixing mechanism, and the permanent magnet 106 of the mixing mechanism drives the magnetic steel ball 101 in the sample cup 102 to rotate, so as to achieve mixing of the reagent and the sample in the sample cup 102. For the purpose of mixing, after the cup gripping hand 109 of the cup gripping mechanism transfers the sample cup 102 to the sample mixing position of the mixing mechanism, the distance between the sample cup 102 and the permanent magnet 106 of the mixing mechanism is maintained within the range of 3 to 5 mm, in order to ensure that the permanent magnet 106 can effectively adsorb the magnetic steel ball 101 in the sample cup 102, so that it can drive the magnetic steel ball 101 to move in the sample cup 102. The distance can be fine-tuned by adjusting the distance using the mounting waist hole of the mixing mechanism, and the cup gripping mechanism can be controlled to reach a specific position in the X and Y directions.

[0037] Note: The trajectory, speed and time of the circular motion of the magnetic steel ball 101 in the sample cup 102 can be adjusted according to the sample detection requirements, and can be clockwise, counterclockwise or a combination of the two.

[0038] In summary, by utilizing the magnetic steel ball 101 inside the sample cup 102, the mixing effect can be improved. At the same time, the circular motion of the magnetic steel ball 101 in the sample cup 102 is not likely to cause small bubbles to be generated in the sample in the sample cup 102. In addition, the mixing time can be shortened, and the test speed, analysis stability and accuracy can be improved. In addition, no foreign objects are added to the sample cup 102 during the mixing process, thereby reducing the probability of mutual contamination of samples. This solves the problem that in the existing sample analysis process, the mixed solution of the sample and the reagent is not mixed evenly, resulting in poor mixing effect, resulting in obvious upper and lower stratification of the sample and the reagent in the sample cup 102, which leads to unstable reaction. In order to meet the detection requirements, it takes a long time to mix the technical problem.

[0039] What is disclosed above is only one or more preferred embodiments of the present application, and cannot be used to limit the scope of rights of the present application. Ordinary technicians in this field can understand that all or part of the processes of implementing the above embodiments and equivalent changes made according to the claims of the present application are still within the scope covered by the present application.

Claims

1. A device for mixing reagents and samples, acting on a sample cup with a magnetic steel ball, characterized in that: It comprises a cup grabbing mechanism and a mixing mechanism, wherein the cup grabbing mechanism is used to grab the sample cup, and the mixing mechanism is used to mix the mixed solution of the reagent and the sample in the sample cup; The mixing mechanism includes a motor mounting frame, a mixing motor, a mixing eccentric wheel and a permanent magnet. The mixing motor is mounted on the motor mounting frame, the mixing eccentric wheel is mounted on the output shaft of the mixing motor, and the permanent magnet is mounted in a hole on the mixing eccentric wheel. There is a certain eccentric distance between the permanent magnet and the output shaft of the mixing motor in the radial direction. The permanent magnet is driven to move by the driving of the mixing motor, so that the permanent magnet adsorbs the magnetic steel ball and drives the magnetic steel ball to move in a circle in the sample cup, thereby achieving mixing of the mixed liquid of the reagent and the sample in the sample cup.

2. The device for mixing reagents and samples as claimed in claim 1, characterized in that: When the permanent magnet drives the magnetic steel ball to perform circular motion to the highest point, the magnetic steel ball should still be located below the mouth of the sample cup, so as to prevent the magnetic steel ball from falling out of the sample cup during the circular motion.

3. The device for mixing reagents and samples as claimed in claim 1, characterized in that: The mixing mechanism also includes a mixing mounting frame and a mixing adjustment block. The mixing mounting frame is installed below the motor mounting frame; and the mixing adjustment block is installed on the mixing mounting frame.

4. The device for mixing reagents and samples as claimed in claim 1, characterized in that: When the mixed solution of the reagent and the sample in the sample cup is mixed, the distance between the sample cup and the permanent magnet is maintained within a range of 3 to 5 mm.

5. The device for mixing reagents and samples as claimed in claim 1, characterized in that: The cup grabbing mechanism comprises a driving block and a cup grabbing hand, wherein the driving block is used to drive the cup grabbing hand to move along the X-axis or the Y-axis, and the cup grabbing hand is used to grab the sample cup.

6. The device for mixing reagents and samples as claimed in claim 5, characterized in that: The driving block includes an X-axis driving motor, an X-axis guide rail, an X-axis slider, a Y-axis driving motor, a Y-axis guide rail and a Y-axis slider. The cup gripper moves along the X-axis through the cooperation of the X-axis driving motor, the X-axis guide rail and the X-axis slider; the cup gripper moves along the Y-axis through the cooperation of the Y-axis driving motor, the Y-axis guide rail and the Y-axis slider.

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