Gene mutation detection device

Abstract

The utility model discloses a gene mutation detection device, which relates to the technical field of gene mutation detection and particularly comprises a shell, a detection cavity is arranged in the shell, a detection probe is fixedly mounted at the top of the detection cavity, a moving plate is arranged below the detection cavity, and two sides of the moving plate are slidably connected with guide rails mounted on the inner wall of the shell through sliders. An opening groove is formed in one side of the shell, one end of the moving plate extends into the opening groove, one end of the moving plate is connected with a telescopic mechanism through a sealing cover plate, the telescopic mechanism is connected with the inner wall of the shell, a detection box is installed at the top of the moving plate, and a storage box with a downward opening is arranged in the detection box. According to the application, the detection tube filled with the treated sample is put into the storage box, then the storage box is directly put into the detection box, and the detection box is moved to the lower part of the detection cavity for detection through the telescopic mechanism, so that the sample is convenient to place, and the use effect is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of gene mutation detection, in particular to a gene mutation detection device. Background Art

[0002] Gene mutation detection refers to the analysis of DNA mutations by establishing a series of electrophoresis to analyze DNA conformation or melting characteristics, or by utilizing characteristics such as DNA denaturation and renaturation.

[0003] Before testing, the existing gene mutation detection device needs to put the test tube containing the sample into a centrifuge or other equipment for pretreatment. After that, the staff needs to open the cover on the detection device, put the test tube containing the processed sample into the detection tray in the detection device, and then close the cover before testing. However, when the number of samples to be tested is large, the staff needs to take the samples out one by one from the pretreatment equipment such as the centrifuge and place them on the well plate, transfer the well plate to the side of the detection device, open the cover on the detection device, and place the test tubes containing the sample one by one on the detection tray in the detection chamber, and then manually cover the cover, which makes the sample placement cumbersome. To this end, we propose a gene mutation detection device. Utility Model Content

[0004] In view of the inconvenience of placing samples in existing gene mutation detection methods, the utility model provides a gene mutation detection device, which has the advantages of being able to place a well plate containing samples into a detection box, and moving the detection box into a shell for detection. The sample placement is convenient, solving the problems raised in the above-mentioned background technology.

[0005] To achieve the above objectives, the utility model is implemented through the following technical solutions: a gene mutation detection device, including a shell, a detection cavity is provided inside the shell, and a detection probe is fixedly installed on the top of the detection cavity;

[0006] A movable plate is provided below the detection cavity, and both sides of the movable plate are slidably connected to guide rails installed on the inner wall of the shell through sliders, an open groove is provided on one side of the shell, one end of the movable plate extends into the open groove, and one end of the movable plate is connected to a telescopic mechanism through a sealing cover plate, and the telescopic mechanism is connected to the inner wall of the shell;

[0007] A detection box is installed on the top of the moving plate, the top of the detection box is flush with the bottom of the detection cavity, a storage box with an opening facing downward is provided inside the detection box, a plurality of receiving holes are provided on the top of the storage box in a matrix, a heat-conducting sleeve with openings at both ends is installed in each receiving hole, and a heating mechanism is also provided inside the storage box;

[0008] A sealing plate is installed at the bottom of the storage box, and a second plug is installed at the bottom of the sealing plate. The second plug is connected to the heating mechanism through a wire. A second socket matching the second plug is installed at the top of the inner part of the detection box, and the second plug is inserted into the second socket. A first plug is installed on one side of the detection box, and the first plug is connected to the second socket through a wire. A first socket matching the first plug is installed on one side of the inner part of the shell, and the first plug is inserted into the first socket.

[0009] Preferably, the heating mechanism includes a heating resistance wire fixed on the outer surface of the heat-conducting sleeve, several heating resistance wires are connected in series through wires, and a snap-type temperature control switch is installed on the outer surface of one of the heat-conducting sleeves, and the snap-type temperature control switch is respectively connected to the heating resistance wire and the second plug through wires.

[0010] Preferably, a heat insulating layer is installed inside the storage box, the heating resistance wire is located in the heat insulating layer, and the heat conductive sleeve and the accommodating hole are separated by the heat insulating layer.

[0011] Preferably, a receiving groove is provided at the bottom of the heat insulation layer, and a closed space is formed between the receiving groove and the sealing plate. A fill light is provided in the space, the fill light is fixed on the sealing plate, and the fill light is connected to the second plug through a wire;

[0012] A light-transmitting hole is provided at the bottom of each receiving hole, the light-transmitting hole penetrates the heat-insulating layer and is connected with the inside of the receiving groove, a light-transmitting plate is provided in the light-transmitting hole, and the light-transmitting holes correspond to the fill lights one by one.

[0013] Preferably, an installation cavity is opened at the bottom of the shell, a control mainboard is installed at the bottom of the installation cavity, an operation screen is installed on the external side of the shell, and the control mainboard is respectively connected to the detection probe, the operation screen and the telescopic mechanism through data cables.

[0014] Preferably, strip-shaped openings are provided on both sides of the detection box.

[0015] Preferably, the size of the sealing cover plate is larger than the size of the opening groove, and the side surface of the sealing cover plate covers the end of the opening groove and is sealed and connected to the side wall of the shell.

[0016] Preferably, a plurality of legs are installed on the bottom edge of the sealing plate, the length of the legs is greater than the length of the second plug, and when the bottom of the legs contacts the inner bottom end of the detection box, the second plug is inserted into the second socket.

[0017] Compared with the prior art, the utility model, when in use, places the test tube containing the processed sample into the storage box, then directly places the storage box into the test box, and moves the test box to the bottom of the test cavity for testing through the telescopic mechanism, so that the sample is conveniently placed and the use effect is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a structural schematic diagram of the utility model.

[0019] Figure 2 It is a side sectional view of the box structure of the utility model.

[0020] Figure 3 It is a side sectional view of the detection box structure of the utility model.

[0021] In the figure: 1. shell; 2. receiving hole; 3. detection box; 4. storage box; 5. sealing cover; 6. movable plate; 7. strip mouth; 8. opening slot; 9. telescopic mechanism; 10. operation screen; 11. detection probe; 12. control main board; 13. installation cavity; 14. first socket; 15. first plug; 16. sudden jump temperature control switch; 17. detection cavity; 18. second plug; 19. second socket; 20. heating resistor wire; 21. fill light; 22. receiving slot; 23. heat insulation layer; 24. support foot; 25. heat conductive sleeve; 26. sealing plate; 27. light-transmitting hole; 28. light-transmitting plate. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0023] See also Figures 1 to 3 The utility model provides a technical solution: a gene mutation detection device, including a housing 1, a detection cavity 17 is provided inside the housing 1, a detection probe 11 is fixedly installed on the top of the detection cavity 17, a mounting cavity 13 is provided at the bottom of the housing 1, a control mainboard 12 is installed at the bottom of the mounting cavity 13, an operation screen 10 is installed on the outer side of the housing 1, and the control mainboard 12 is connected to the detection probe 11 and the operation screen 10 through data lines. The control mainboard 12 is a PCB circuit board or a single-chip circuit board. The staff can input the detection content into the control mainboard 12 through the operation screen 10, and the control mainboard 12 controls the detection probe 11 to detect the sample, and transmits the detection data to the operation screen 10 for the staff to observe.

[0024] like Figure 2As shown, a movable plate 6 is provided below the detection chamber 17, and both sides of the movable plate 6 are slidably connected to the guide rails installed on the inner wall of the housing 1 through sliders, so that the movable plate 6 remains stable. An open slot 8 is provided on one side of the housing 1, and one end of the movable plate 6 extends into the open slot 8, and one end of the movable plate 6 is connected to a telescopic mechanism 9 through a sealing cover plate 5, and the telescopic mechanism 9 is connected to the inner wall of the housing 1, and the control main board 12 is connected to the telescopic mechanism 9 through a wire. The telescopic mechanism 9 is one of an electric push rod, a cylinder or a hydraulic rod. When in use, the telescopic mechanism 9 can move the movable plate 6 into the housing 1 to allow the detection probe 11 to detect the sample.

[0025] It should be noted that the size of the sealing cover plate 5 is larger than the size of the opening groove 8. During detection, the sealing cover plate 5 can seal the opening groove 8, so that the interior of the housing 1 is a sealed space, which can prevent the sample detection result from being affected by the external environment.

[0026] like Figure 1 and Figure 3 As shown, a detection box 3 is installed on the top of the movable plate 6, and the top of the detection box 3 is flush with the bottom of the detection chamber 17. A storage box 4 with an opening facing downward is provided inside the detection box 3. A plurality of receiving holes 2 are provided on the top of the storage box 4 in a matrix, and a heat-conducting sleeve 25 with openings at both ends is installed in each receiving hole 2. A heating mechanism is also provided inside the storage box 4, and the heating mechanism includes a heating resistance wire 20 fixed on the outer surface of the heat-conducting sleeve 25, and a plurality of heating resistance wires 20 are connected in series through a wire, and a snap-type temperature control switch 16 is installed on the outer surface of one of the heat-conducting sleeves 25. A sealing plate 26 is installed at the bottom of the storage box 4, and a second plug 18 is installed at the bottom of the sealing plate 26. The snap-type temperature control switch 16 is connected to the heating resistance wire 20 and the second plug 18 through wires. When in use, the detection tube containing the sample is placed in the heat-conducting sleeve 25, and the sample can be heated by the heating resistance wire 20, so that the sample is kept within a preset temperature range, which is conducive to detection.

[0027] like Figure 2 and Figure 3 As shown, the inner top of the detection box 3 is correspondingly provided with a second socket 19 matching the second plug 18, and the bottom edge of the sealing plate 26 is provided with a plurality of legs 24, the length of which is greater than the length of the second plug 18. In this way, the legs 24 can support the sealing plate 26, so that the sealing plate 26 remains stable when placed, and can protect the second plug 18 to prevent the second plug 18 from being damaged by collision with foreign objects when the storage box 4 is placed. In actual use, when the bottom of the legs 24 contacts the inner bottom end of the detection box 3, the second plug 18 is inserted into the second socket 19, so that the second plug 18 and the second socket 19 can be connected together.

[0028] like Figure 2As shown, a first plug 15 is installed on one side of the detection box 3, and the first plug 15 is connected to the second socket 19 through a wire. A first socket 14 matching the first plug 15 is correspondingly installed on one side of the inner side of the housing 1, and the first plug 15 is inserted into the first socket 14. In actual use, when the telescopic mechanism 9 drives the moving plate 6 to move to a preset position inside the housing 1, the first plug 15 is inserted into the first socket 14, so that the heating resistance wire 20 can be connected to the circuit, and the heating resistance wire 20 can work normally.

[0029] It should be noted that the first plug 15 and the second plug 18 are both sheet-like structures, and the first socket 14 and the second socket 19 are both U-shaped structures. When in use, the first plug 15 is inserted into the first socket 14, and the second plug 18 is inserted into the second socket 19 to connect the circuit.

[0030] Specifically, when the utility model is in use, the staff puts the processed detection tube containing the sample to be detected into the heat-conducting sleeve 25, and puts the storage box 4 in the detection box 3, so that the second plug 18 is inserted into the second socket 19, and then the detection box 3 is moved into the shell 1 through the telescopic mechanism 9. When the detection box 3 moves to the preset position, the first plug 15 is inserted into the first socket 14, the circuit is connected, the heating resistor 20 works, and the sample is heated. When the temperature is too high, the sudden jump temperature control switch 16 is disconnected, and the heating resistor 20 is powered off and stops working. When the temperature is too low, the sudden jump temperature control switch 16 is closed, and the heating resistor 20 is powered on to start heating, so that the sample is kept within the preset temperature range, and then the sample is detected by the detection probe 11.

[0031] Further, such as Figure 3 As shown, a heat insulating layer 23 is installed inside the storage box 4, the heating resistor 20 is located in the heat insulating layer 23, and the heat conductive sleeve 25 is separated from the receiving hole 2 by the heat insulating layer 23. In this way, the heat generated by the heating resistor 20 will be isolated by the heat insulating layer 23, and the heat insulating layer 23 is a heat insulating material such as heat insulating cotton, heat insulating aerogel board or heat insulating ceramic board, and the heat will not be transferred to the outside of the storage box 4, thereby preventing the staff from being burned when taking the storage box 4 after the inspection.

[0032] It should be noted that strip openings 7 are provided on both sides of the detection box 3. When taking the storage box 4 out of the detection box 3, the staff can clamp the storage box 4 with their fingers through the strip openings 7, and then pull the storage box 4 upward to take it out, which is convenient.

[0033] Further, such as Figure 3As shown, a receiving groove 22 is provided at the bottom of the heat-insulating layer 23, and a closed space is formed between the receiving groove 22 and the sealing plate 26. A fill light 21 is provided in the space, and the fill light 21 is fixed on the sealing plate 26. The fill light 21 is connected to the second plug 18 through a wire. A light-transmitting hole 27 is provided at the bottom of each receiving hole 2. The light-transmitting hole 27 penetrates the heat-insulating layer 23 and is connected to the inside of the receiving groove 22. A light-transmitting plate 28 is provided in the light-transmitting hole 27. The light-transmitting hole 27 corresponds to the fill light 21 one by one. The light-transmitting plate 28 is made of transparent glass or transparent plastic or transparent aerogel. The light-transmitting plate 28 is mainly used to block the light-transmitting hole 27 to prevent heat from being transferred to the receiving groove 22 to damage the fill light 21, and to allow light to pass through and shine into the receiving hole 2. During detection, the fill light 21 emits light, and the light passes through the light-transmitting hole 27 to illuminate the sample, which is convenient for detection.

[0034] In the description of the present utility model, it should be noted that the orientation or position relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inside", "outside", etc. is based on the orientation or position relationship shown in the drawings, which is only for the convenience of describing the present utility model and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present utility model; the terms "first", "second", and "third" are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance. In addition, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not expressly listed, or also includes elements inherent to such process, method, article, or apparatus.

[0035] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A gene mutation detection device, comprising a housing (1), a detection chamber (17) being provided inside the housing (1), a detection probe (11) being fixedly mounted on the top of the detection chamber (17), characterized in that: A movable plate (6) is provided below the detection chamber (17), and both sides of the movable plate (6) are slidably connected to guide rails installed on the inner wall of the housing (1) via sliders; an opening groove (8) is provided on one side of the housing (1), one end of the movable plate (6) extends into the opening groove (8), and one end of the movable plate (6) is connected to a telescopic mechanism (9) via a sealing cover plate (5), and the telescopic mechanism (9) is connected to the inner wall of the housing (1); A detection box (3) is installed on the top of the movable plate (6), a storage box (4) with an opening facing downward is provided inside the detection box (3), a plurality of receiving holes (2) are provided on the top of the storage box (4) in a matrix, a heat-conducting sleeve (25) with openings at both ends is installed in each of the receiving holes (2), and a heating mechanism is also provided inside the storage box (4); A sealing plate (26) is installed at the bottom of the storage box (4), a second plug (18) is installed at the bottom of the sealing plate (26), the second plug (18) is connected to the heating mechanism through a wire, a second socket (19) matching the second plug (18) is installed at the top of the interior of the detection box (3), the second plug (18) is inserted into the second socket (19), a first plug (15) is installed at one side of the detection box (3), the first plug (15) is connected to the second socket (19) through a wire, and a first socket (14) matching the first plug (15) is installed at one side of the interior of the housing (1), the first plug (15) is inserted into the first socket (14).

2. A gene mutation detection device according to claim 1, characterized in that: The heating mechanism comprises a heating resistance wire (20) fixed on the outer surface of a heat-conducting sleeve (25), a plurality of heating resistance wires (20) are connected in series via a wire, and a snap-action temperature control switch (16) is installed on the outer surface of one of the heat-conducting sleeves (25), and the snap-action temperature control switch (16) is respectively connected to the heating resistance wire (20) and a second plug (18) via a wire.

3. A gene mutation detection device according to claim 2, characterized in that: A heat insulation layer (23) is installed inside the storage box (4), and the heating resistance wire (20) is located inside the heat insulation layer (23).

4. A gene mutation detection device according to claim 3, characterized in that: A receiving groove (22) is provided at the bottom of the heat insulating layer (23), and a closed space is formed between the receiving groove (22) and the sealing plate (26). A fill light (21) is provided in the space, and the fill light (21) is fixed on the sealing plate (26). The fill light (21) is connected to the second plug (18) via a wire. A light-transmitting hole (27) is provided at the bottom of each receiving hole (2), the light-transmitting hole (27) penetrates the heat-insulating layer (23) and is communicated with the interior of the receiving groove (22), a light-transmitting plate (28) is provided in the light-transmitting hole (27), and the light-transmitting holes (27) correspond one to one with the fill light (21).

5. A gene mutation detection device according to claim 1, characterized in that: The bottom of the housing (1) is provided with an installation cavity (13), the bottom of the installation cavity (13) is provided with a control mainboard (12), the external side of the housing (1) is provided with an operation screen (10), and the control mainboard (12) is respectively connected to the detection probe (11), the operation screen (10) and the telescopic mechanism (9) via data cables.

6. A gene mutation detection device according to claim 1, characterized in that: Strip-shaped openings (7) are provided on both sides of the detection box (3).

7. A gene mutation detection device according to claim 1, characterized in that: The size of the sealing cover plate (5) is larger than the size of the opening groove (8), and the side surface of the sealing cover plate (5) covers the end of the opening groove (8) and is sealedly connected to the side wall of the housing (1).

8. A gene mutation detection device according to claim 1, characterized in that: A plurality of legs (24) are installed on the bottom edge of the sealing plate (26), the length of the legs (24) is greater than the length of the second plug (18), and when the bottom of the legs (24) contacts the inner bottom end of the detection box (3), the second plug (18) is inserted into the second socket (19).

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