Automatic sample introduction mechanism and sample introduction device applied to mass spectrometer analysis

Abstract

The utility model discloses an automatic sample introduction mechanism and a sample introduction device applied to mass spectrometer analysis. The automatic sample introduction mechanism comprises a reagent disc movement assembly, the puncture needle movement assembly is movably arranged above the reagent disc movement assembly and comprises a lateral transverse movement mechanism arranged on the reagent disc movement assembly; the rotating mechanism is movably arranged on the transverse movement mechanism, and the transverse movement mechanism can drive the rotating mechanism to move in the X-axis direction; the telescopic puncture needle mechanism is movably arranged in the rotating mechanism and comprises a puncture needle structure, and the puncture needle structure can move in the Z-axis direction; the rotating mechanism can drive the puncture needle structure to rotate. According to the utility model, through the cooperation of the reagent disc movement assembly, the transverse movement mechanism, the rotating mechanism and the telescopic puncture needle mechanism, the automatic sampling operation of the puncture needle structure is effectively realized.

Description

Technical Field

[0001] The utility model relates to the technical field of sample injection mechanisms, and in particular to an automatic sample injection mechanism and a sample injection device applied to mass spectrometer analysis. Background Art

[0002] A mass spectrometer, also known as a mass spectrometer, is centered around an ion source, a mass analyzer, and an ion detector. The ion source is a device that ionizes sample molecules under high vacuum conditions. The ionized molecules will further break into a variety of smaller mass fragment ions and neutral particles due to excessive energy received. They enter the mass analyzer with average kinetic energy of the same energy under the action of an accelerating electric field. The mass analyzer is a device that separates ions of different masses that enter it at the same time according to their mass-to-charge ratio m / e. The separated ions enter the ion detector in turn, collect and amplify ion signals, and are processed by a computer to draw a mass spectrum. Existing mass spectrometers generally perform sample addition operations manually. With the continuous increase in labor costs, the cost of mass spectrometer analysis is high, and the efficiency of manual sample addition is also low. Utility Model Content

[0003] One of the purposes of the utility model is to provide an automatic sample injection mechanism and a sample injection device applied to mass spectrometer analysis, so as to solve the problem of low sample injection efficiency in the existing mass spectrometer analysis process.

[0004] The utility model provides an automatic sample injection mechanism and a sample injection device for mass spectrometer analysis, which can be realized by the following technical solutions:

[0005] The utility model discloses an automatic sample injection mechanism for mass spectrometer analysis, comprising: a reagent disk motion component, which can drive the reagent disk arranged thereon to move in the Y-axis direction; a puncture needle motion component, which is movably arranged above the reagent disk motion component, and can move relative to the reagent disk motion component in the X-axis and Z-axis directions;

[0006] Among them, the puncture needle movement assembly includes a lateral movement mechanism, which is arranged on the side of the reagent disk movement assembly; a rotating mechanism movably arranged on the lateral movement mechanism, and the lateral movement mechanism can drive the rotating mechanism to move in the X-axis direction; a telescopic puncture needle mechanism movably arranged in the rotating mechanism, which includes a puncture needle structure, and the puncture needle structure can move in the Z-axis direction; the rotating mechanism can drive the puncture needle structure to rotate.

[0007] In one embodiment, the lateral motion mechanism includes a second drive motor; a second driving wheel transmission-mounted on the second drive motor; a second driven wheel transmission-connected to the second driving wheel via a second transmission belt; a guide rail parallel to the side of the second transmission belt; and a sliding block movably mounted on the guide rail, and the rotating mechanism is fixedly connected to the second transmission belt and the sliding block, respectively.

[0008] In one embodiment, the rotating mechanism includes a fixed seat, which is fixedly connected to the second transmission belt and the sliding block respectively; a rotating drive motor fixedly arranged on the fixed seat; and a shell connected to the rotating drive motor, which is a hollow cavity, and the rotating drive motor drives the shell to rotate.

[0009] In one embodiment, the telescopic puncture needle mechanism also includes a third drive motor, which is fixedly disposed in the shell; a transmission structure transmission-connected to the third drive motor; a guide sleeve fixedly disposed in the shell; the puncture needle structure is transmission-connected to the transmission structure and passes through the guide sleeve and the shell in sequence.

[0010] In one embodiment, the transmission structure includes a driving wheel and a driven wheel and a transmission belt that are relatively arranged, the driving wheel is transmission-connected to the third driving motor, and the driven wheel is movably arranged in the shell; a transmission belt is arranged between the driving wheel and the driven wheel, and the puncture needle structure is arranged on the transmission belt.

[0011] In one embodiment, the reagent disk movement assembly includes a first drive motor; a first driving wheel transmission-mounted on the first drive motor; a first driven wheel transmission-connected to the first driving wheel via a first transmission belt; a connecting member fixedly mounted on the first transmission belt; and a limiting disk fixedly connected to the first transmission belt via the connecting member.

[0012] In one embodiment, at least one tensioning wheel is disposed on the first transmission belt and the second transmission belt.

[0013] In one embodiment, the limiting plate is a hollow cavity, and at least one guide block is fixedly disposed on the bottom of the limiting plate.

[0014] The utility model provides a sample injection device applied to mass spectrometer analysis, comprising any one of the above-mentioned automatic sample injection mechanisms and a sample injection device body, wherein the automatic sample injection mechanism is arranged in the sample injection device body.

[0015] In one embodiment, the main body of the sampling device includes a main shell, the automatic sampling mechanism is arranged in the main shell; a cover body movably arranged on the main shell; a control mechanism and a cleaning mechanism are respectively arranged in the main shell, the control mechanism is electrically connected to the automatic sampling mechanism and the cleaning mechanism respectively, and the cleaning mechanism is arranged on the side of the automatic sampling mechanism.

[0016] Compared with the prior art, the utility model has the following beneficial effects:

[0017] The utility model discloses an automatic sampling mechanism and a sampling device applied to mass spectrometer analysis, which effectively realize the automatic sampling operation of the puncture needle structure through the cooperation of a reagent tray motion component, a lateral motion mechanism, a rotation mechanism and a telescopic puncture needle mechanism, thereby improving the analysis efficiency of the mass spectrometer to a certain extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the utility model and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 It is a structural schematic diagram of an automatic sample injection mechanism used for mass spectrometer analysis of the utility model, including a reagent tray motion component and a puncture needle motion component;

[0020] Figure 2 yes Figure 1 The schematic diagram of the structure of the reagent disk motion assembly shown includes a limit disk;

[0021] Figure 3 yes Figure 2 The structural schematic diagram of the limit plate shown;

[0022] Figure 4 yes Figure 1 The schematic structural diagram of the puncture needle motion assembly shown includes a lateral motion mechanism, a rotation mechanism and a telescopic puncture needle mechanism;

[0023] Figure 5 yes Figure 4 The structural schematic diagram of the lateral motion mechanism shown;

[0024] Figure 6 yes Figure 4 A schematic diagram of the connection structure of the rotating mechanism and the telescopic puncture needle mechanism shown;

[0025] Figure 7It is a structural schematic diagram of a sample injection device used for mass spectrometer analysis in the utility model;

[0026] Figure 8 yes Figure 7 The utility model is a schematic diagram of an explosion structure of a sample injection device used for mass spectrometer analysis.

[0027] In the figure, the following are marked: 10, automatic injection mechanism; 11, reagent tray motion assembly; 111, first drive motor; 112, first driving wheel; 113, first driven wheel; 114, first transmission belt; 115, connecting piece; 116, limit plate; 1161, limit block; 1162, guide block; 11621, fixing hole; 117, first tensioning wheel; 12, puncture needle motion assembly; 121, lateral motion mechanism; 1211, second drive motor; 1212, second driving wheel; 1213, second driven wheel; 1214, second transmission belt; 1215, guide rail; 1216, sliding block; 1217, second tensioning wheel; 122, rotating mechanism; 1221, fixed seat; 1222, rotating drive motor; 1223, shell; 123, telescopic puncture needle mechanism; 1231, third drive motor; 1232, transmission structure; 1233, guide sleeve; 1234, puncture needle structure; 13, reagent disk; 20, injection device body; 21, main shell; 22, cover body; 23, control mechanism; 24, cleaning mechanism. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all of the embodiments. The components of the embodiment of the utility model described and shown in the drawings here can be arranged and designed in various different configurations.

[0029] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the present invention to be protected, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] See also Figure 1-Figure 6As shown, the utility model discloses an automatic sample introduction mechanism 10 for mass spectrometer analysis, comprising a reagent tray motion assembly 11 and a puncture needle motion assembly 12; the reagent tray motion assembly 11 can drive a reagent tray 13 arranged thereon to move in the Y-axis direction; the puncture needle motion assembly 12 is movably arranged above the reagent tray motion assembly 11, and can move in the X-axis and Z-axis directions relative to the reagent tray motion assembly 11, and the automatic sample introduction operation of mass spectrometer analysis is realized through the cooperation of the reagent tray motion assembly 11 and the puncture needle motion assembly 12.

[0031] See also Figure 1 and Figure 2 As shown, in the present embodiment, the reagent tray movement assembly 11 comprises a first driving motor 111, a first driving wheel 112, a first driven wheel 113, a first transmission belt 114, a connecting member 115 and a limiting disk 116; the first driving motor 111 is a power source; the first driving wheel 112 is transmission-arranged on the first driving motor 111; the first driven wheel 113 is transmission-connected to the first driving wheel 112 through the first transmission belt 114, and the first driving motor 111 drives the first driving wheel 112 to drive the first transmission belt 114 to move; the connecting member 115 is fixedly arranged on the first transmission belt 114 and moves following the movement of the first transmission belt 114; the limiting disk 116 is fixedly connected to the first transmission belt 114 through the connecting member 115, so that the limiting disk 116 moves following the movement of the first transmission belt 114, so that the reagent tray 13 arranged on the limiting disk 116 moves in the Y-axis direction. Specifically, the first driving motor 111 adopts a servo motor, so as to ensure the precise movement of the limit plate 116 in the Y-axis direction; at least one first tensioning wheel 117 is also provided on the first transmission belt 114, and the first tensioning wheel 117 is used to tighten and steer the first transmission belt 114.

[0032] See also Figure 2 and Figure 3 As shown, the limiting disk 116 is a hollow cavity, and at least one reagent disk 13 can be detachably engaged with the limiting disk 116, so that the multiple reagent bottles on the reagent disk 13 are evenly and equidistantly arranged on the limiting disk 116, and they move with the movement of the limiting disk 116; specifically, a plurality of limiting blocks 1161 are provided in the limiting disk 116, and the reagent disk 13 arranged thereon is limited, engaged and fixed by the corresponding limiting blocks 1161; at least one guide block 1162 is fixedly provided at the bottom of the limiting disk 116, and the movement of the limiting disk 116 is guided by at least one guide block 1162; in this embodiment, two guide blocks 1162 are integrally formed and fixedly provided at the bottom of the limiting disk 116, and a fixing hole 11621 is penetrated on the guide block 1162, which is fixedly connected to the connecting member 115 through the fixing hole 11621, so that the first transmission belt 114 drives the limiting disk 116 to move in the Y-axis direction.

[0033] See also Figure 1 and Figure 4 As shown, in this embodiment, the puncture needle movement assembly 12 includes a lateral movement mechanism 121, a rotation mechanism 122 and a retractable puncture needle mechanism 123; the lateral movement mechanism 121 is arranged on the side of the reagent disk movement assembly 11; the rotation mechanism 122 is movably arranged on the lateral movement mechanism 121, and the lateral movement mechanism 121 drives the rotation mechanism 122 to move in the X-axis direction; the retractable puncture needle mechanism 123 is movably arranged in the rotation mechanism 122, and the rotation mechanism 122 drives the retractable puncture needle mechanism 123 to rotate at an angle.

[0034] See also Figure 4 and Figure 5 As shown, in this embodiment, the lateral motion mechanism 121 includes a second driving motor 1211, a second driving wheel 1212, a second driven wheel 1213, a second transmission belt 1214, a guide rail 1215 and a sliding block 1216; the second driving motor 1211 is a power source; the second driving wheel 1212 is transmission-disposed on the second driving motor 1211; the second driven wheel 1213 is transmission-connected to the second driving wheel 1212 through the second transmission belt 1214, and the second driving motor 1211 drives the second driving wheel 1212. The driving wheel 1212 drives the second transmission belt 1214 to move; the guide rail 1215 is arranged parallel to one side of the second transmission belt 1214; the sliding block 1216 is movably arranged on the guide rail 1215, the rotating mechanism 122 is fixedly connected to the second transmission belt 1214 and the sliding block 1216 respectively, the second driving motor 1211 drives the rotating mechanism 122 to move in the X-axis direction through the second transmission belt 1214, and the guide rail 1215 guides the rotating mechanism 122 arranged on the sliding block 1216. Specifically, the second driving motor 1211 adopts a servo motor, so as to ensure the precise movement of the rotating mechanism 122 in the X-axis direction; at least one second tensioning wheel 1217 is also arranged on the second transmission belt 1214, and the second transmission belt 1214 is tightened and turned by the second tensioning wheel 1217.

[0035] See also Figure 4 and Figure 6 As shown, in this embodiment, the rotating mechanism 122 includes a fixed seat 1221, a rotating drive motor 1222 and; the fixed seat 1221 is fixedly connected to the second transmission belt 1214 and the sliding block 1216 respectively, and the second drive motor 1211 drives the fixed seat 1221 to move along the direction of the guide rail 1215 through the second transmission belt 1214; the rotating drive motor 1222 is fixedly arranged on the fixed seat 1221; the shell 1223 is a hollow cavity and is connected to the rotating drive motor 1222, and the rotating drive motor 1222 drives the shell 1223 to rotate.

[0036] See also Figure 4and Figure 6 As shown, in this embodiment, the telescopic puncture needle mechanism 123 includes a third drive motor 1231, a transmission structure 1232, a guide sleeve 1233 and a puncture needle structure 1234; the third drive motor 1231 is fixedly arranged in the shell 1223; the transmission structure 1232 is transmission-connected to the third drive motor 1231; the guide sleeve 1233 is fixedly arranged in the shell 1223; the puncture needle structure 1234 is transmission-connected to the transmission structure 1232 and passes through the guide sleeve 1233 and the shell 1223 in sequence, and the third drive motor 1231 drives the puncture needle structure 1234 to move in the X-axis direction through the transmission structure 1232, thereby extending into the corresponding reagent bottle in the reagent disk 13 to perform a sampling operation. Specifically, the third drive motor 1231 adopts a servo motor to ensure the precise movement of the puncture needle structure 1234 in the Z-axis direction; the transmission structure 1232 includes a driving wheel, a driven wheel and a transmission belt, the driving wheel and the driven wheel are arranged relatively to each other, the driving wheel is connected to the third drive motor 1231 in transmission, the driven wheel is movably arranged in the shell 1223, the transmission belt is arranged between the driving wheel and the driven wheel, and the puncture needle structure 1234 is arranged on the transmission belt; the puncture needle structure 1234 adopts the existing technology, so its specific structure and working process are not described here, as long as it meets the present application.

[0037] See also Figure 7 and Figure 8 As shown, the utility model provides a sample injection device for mass spectrometer analysis, comprising any one of the above-mentioned automatic sample injection mechanism 10 and a sample injection device body 20 , wherein the automatic sample injection mechanism 10 is disposed in the sample injection device body 20 . Specifically, the sampling device body 20 includes a main shell 21, a cover body 22, a control mechanism 23 and a cleaning mechanism 24; the main shell 21 is a supporting body, and the automatic sampling mechanism 10, the control mechanism 23 and the cleaning mechanism 24 are respectively arranged in the main shell 21; the cover body 22 is movably arranged on the main shell 21, so that the reagent disk 13 to be sampled is conveniently placed on the automatic sampling mechanism 10 arranged in the main shell 21 for automatic sampling operation; the control mechanism 23 is electrically connected to the automatic sampling mechanism 10 and the cleaning mechanism 24 respectively, and the control technologies adopted are all existing technologies, so the specific control process and the models adopted are not described here, as long as the present application is met; the cleaning mechanism 24 is arranged on the side of the automatic sampling mechanism 10, and it cleans the puncture needle structure 1234. The cleaning mechanism 24 adopts existing technologies, so the specific structure and working process are not described here, as long as the present application is met.

[0038] It should be noted that the specific working process of the automatic sampling mechanism and sampling device of the utility model applied to mass spectrometer analysis is: the reagent tray 13 is placed on the limit disk 116 in advance, and the first drive motor 111 drives the reagent tray 13 set on the limit disk 116 to move precisely in the Y-axis direction through the first transmission belt 114; at the same time, the lateral movement mechanism 121 and the third drive motor 1231 cooperate to drive the puncture needle structure 1234 to move precisely in the X-axis and Z-axis directions, so that the puncture needle structure 1234 can sample multiple reagent bottles on the reagent tray 13 in turn; then the puncture needle structure 1234 after sampling is driven by the rotating mechanism 122 to rotate 90 degrees, and then the puncture needle structure 1234 after sampling is sent to the mass spectrometer under the drive of the lateral movement mechanism 121, thereby completing the automatic sampling operation.

[0039] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0040] The above-mentioned embodiments only express several implementation methods of the utility model, and the description is relatively specific and detailed, but it cannot be understood as limiting the scope of the utility model patent. It should be pointed out that for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the utility model, which all belong to the protection scope of the utility model. Therefore, the protection scope of the utility model patent shall be based on the attached claims.

Claims

1. An automatic sample injection mechanism for mass spectrometer analysis, characterized in that: include: A reagent disk moving assembly, which can drive the reagent disk disposed thereon to move in the Y-axis direction; A puncture needle motion assembly, which is movably arranged above the reagent disk motion assembly and can move relative to the reagent disk motion assembly in the X-axis and Z-axis directions; Among them, the puncture needle movement assembly includes a lateral movement mechanism, which is arranged on the side of the reagent disk movement assembly; a rotating mechanism movably arranged on the lateral movement mechanism, and the lateral movement mechanism can drive the rotating mechanism to move in the X-axis direction; a telescopic puncture needle mechanism movably arranged in the rotating mechanism, which includes a puncture needle structure, and the puncture needle structure can move in the Z-axis direction; the rotating mechanism can drive the puncture needle structure to rotate.

2. The automatic sample introduction mechanism for mass spectrometer analysis according to claim 1, characterized in that: The lateral motion mechanism includes a second driving motor; a second driving wheel transmission-mounted on the second driving motor; a second driven wheel transmission-connected to the second driving wheel via a second transmission belt; a guide rail parallel to the side of the second transmission belt; and a sliding block movably arranged on the guide rail, and the rotating mechanism is fixedly connected to the second transmission belt and the sliding block respectively.

3. The automatic sample introduction mechanism for mass spectrometer analysis according to claim 2, characterized in that: The rotating mechanism includes a fixed seat, which is fixedly connected to the second transmission belt and the sliding block respectively; a rotating drive motor fixedly arranged on the fixed seat; a shell connected to the rotating drive motor, which is a hollow cavity, and the rotating drive motor drives the shell to rotate.

4. The automatic sample introduction mechanism for mass spectrometer analysis according to claim 3, characterized in that: The telescopic puncture needle mechanism also includes a third drive motor, which is fixedly arranged in the shell; a transmission structure transmission-connected to the third drive motor; a guide sleeve fixedly arranged in the shell; the puncture needle structure is transmission-connected to the transmission structure and passes through the guide sleeve and the shell in sequence.

5. The automatic sample introduction mechanism for mass spectrometer analysis according to claim 4, characterized in that: The transmission structure includes a driving wheel and a driven wheel and a transmission belt that are relatively arranged, the driving wheel is in transmission connection with the third driving motor, and the driven wheel is movably arranged in the shell; a transmission belt is arranged between the driving wheel and the driven wheel, and the puncture needle structure is arranged on the transmission belt.

6. The automatic sample introduction mechanism for mass spectrometer analysis according to claim 2, characterized in that: The reagent disk motion assembly includes a first drive motor; a first driving wheel that is transmission-disposed on the first drive motor; a first driven wheel that is transmission-connected to the first driving wheel via a first transmission belt; a connecting member that is fixedly disposed on the first transmission belt; and a limiting disk that is fixedly connected to the first transmission belt via the connecting member.

7. The automatic sample introduction mechanism for mass spectrometer analysis according to claim 6, characterized in that: At least one tensioning wheel is arranged on the first transmission belt and the second transmission belt.

8. The automatic sample introduction mechanism for mass spectrometer analysis according to claim 6, characterized in that: The limiting plate is a hollow cavity, and at least one guide block is fixedly arranged at the bottom of the limiting plate.

9. A sample injection device for mass spectrometer analysis, characterized in that: It comprises the automatic sampling mechanism and the sampling device body according to any one of claims 1 to 8, wherein the automatic sampling mechanism is arranged in the sampling device body.

10. The sample injection device for mass spectrometer analysis according to claim 9, characterized in that: The main body of the sampling device includes a main shell, the automatic sampling mechanism is arranged in the main shell; a cover body movably arranged on the main shell; a control mechanism and a cleaning mechanism are respectively arranged in the main shell, the control mechanism is electrically connected to the automatic sampling mechanism and the cleaning mechanism respectively, and the cleaning mechanism is arranged on the side of the automatic sampling mechanism.

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