Tablet disintegration equipment

Abstract

The utility model relates to the technical field of tablet detection, and discloses tablet disintegration equipment, which comprises a container, a sieve tray is detachably arranged at the top of the container, the sieve tray comprises a concave sieve, the sieve is used for placing tablets, a height-adjustable dropping pipette with scales is arranged above the sieve, and the dropping pipette is used for dropping liquid media into the tablets. According to the tablet disintegration equipment, the liquid medium is dropwise added to the tablets on the screen mesh through the liquid dropping pipe, and after the tablets are infiltrated by the liquid medium, redundant liquid is timely discharged into the container through the screen mesh, so that the quantity of the liquid medium in contact with the tablet samples is stable, and the tablet samples with relatively high disintegration speed are not easy to completely dissolve in a short time; an operator can conveniently observe the disintegration phenomenon in the infiltration process of the tablet sample, the size of the disintegrated particles is evaluated by observing the passing rate of the particles generated after the tablet sample is broken in the screen, and the operator can conveniently analyze the tablet sample.

Description

Technical Field

[0001] The utility model relates to the technical field of tablet detection, in particular to a tablet disintegration device. Background Art

[0002] Tablets usually refer to a form of pharmaceutical preparation, that is, the drug is compressed into a flat, round or other shaped solid tablet, which usually includes active ingredients and auxiliary ingredients. Tablet disintegration test is an important test in drug quality control and drug production process, and its main purpose is to evaluate the dissolution performance and drug release rate of oral tablets in the gastrointestinal tract.

[0003] The commonly used tablet disintegration method on the market is to place the tablet in a beaker containing a liquid medium (the liquid medium is used to simulate gastric juice and intestinal juice). The tablet gradually disintegrates under the action of the liquid medium, and the operator observes the disintegration of the tablet and analyzes the differences between different tablets. However, for tablet varieties with a faster disintegration rate, such as orodisintegrating tablets, the disintegration in the liquid medium is more violent and will be completely dissolved in a short time, making it difficult for operators to clearly observe the state of the particles disintegrated from the tablet in a short time, and thus it is difficult to analyze the differences between tablet samples based on the tablet disintegration phenomenon. Utility Model Content

[0004] The purpose of the utility model is to provide a tablet disintegration device to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a tablet disintegration device, comprising: a container, a sieve plate is detachably provided on the top of the container, the sieve plate comprises a concave sieve, the sieve is used to place tablets, a height-adjustable dropper with a scale is provided above the sieve, the dropper is used to drip liquid medium onto the tablets.

[0006] Preferably, the sieve plate further comprises an outer frame, and the sieve is fixed inside the outer frame.

[0007] Preferably, the outer diameter of the outer frame is larger than the outer diameter of the container.

[0008] Preferably, at least two positioning columns are fixedly mounted on the bottom of the outer frame, and the positioning columns are arranged in the container and abut against the inner wall of the container.

[0009] Preferably, it also includes an iron frame, on which an adjustment member is arranged.

[0010] Preferably, the adjusting member comprises a fitting portion, and the fitting portion extends to one side to form two fixing portions.

[0011] Preferably, the fixing portion fixes the fitting portion to the iron frame by means of bolts.

[0012] Preferably, the fitting portion is fixedly mounted with a connecting rod, and the drip tube passes through the connecting rod.

[0013] Preferably, the connecting rod is provided with a clamp, and the clamp is used to clamp the drip tube.

[0014] Preferably, the drip tube is provided with a regulating valve.

[0015] The tablet disintegration equipment has the following beneficial effects:

[0016] The tablet disintegration equipment drips liquid medium onto the tablet on the screen through a dropper. After the liquid medium soaks the tablet, the excess liquid is promptly discharged into the container through the screen, thereby ensuring that the amount of liquid medium contacted by the tablet sample is stable, so that the tablet sample with a faster disintegration speed is not easy to completely dissolve in a short time, and it is convenient for operators to observe the disintegration phenomenon occurring during the soaking process of the tablet sample, and to evaluate the size of the disintegrated particles by observing the passing rate of particles generated after the tablet sample is crushed in the screen, so as to facilitate the analysis of the tablet sample by the operators. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic diagram of a tablet disintegration device provided in an embodiment of the present application;

[0018] Figure 2 for Figure 1 Schematic diagram of the dropper;

[0019] Figure 3 for Figure 1 Schematic diagram of the middle adjustment member;

[0020] Figure 4 for Figure 1 Cross-sectional view of the middle sieve plate.

[0021] In the figure: 1. iron frame; 2. adjusting part; 21. fitting part; 22. fixing part; 3. connecting rod; 31. clamp; 4. drip tube; 41. regulating valve; 5. container; 6. sieve plate; 61. outer frame; 62. sieve; 63. positioning column. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0023] like Figure 1 , Figure 3As shown, the utility model provides an embodiment of a tablet disintegration device, comprising: an iron frame 1, an adjusting member 2 is arranged on the iron frame 1, the adjusting member 2 comprises a fitting portion 21, the fitting portion 21 is in a circular ring shape and surrounds the outer surface of the column of the iron frame 1, the fitting portion 21 extends to one side to form two fixing portions 22, and the two fixing portions 22 fix the fitting portion 21 to the iron frame 1 by bolts.

[0024] The fitting portion 21 is fixedly mounted with a connecting rod 3, through which a drip tube 4 is passed, and the drip tube 4 has scales for conveniently dripping a preset amount of liquid medium onto the tablet.

[0025] Specifically, Figure 2 As shown, the connecting rod 3 is provided with a clamp 31 , the clamp 31 is used to clamp the dripping tube 4 , and the dripping tube 4 is provided with a regulating valve 41 .

[0026] like Figure 1 , Figure 4 As shown, the tablet disintegration device also includes: a container 5, a sieve plate 6 is detachably provided on the top of the container 5, the sieve plate 6 also includes an outer frame 61, the outer diameter of the outer frame 61 is larger than the outer diameter of the container 5 to prevent the sieve plate 6 from falling into the container 5, and at least two positioning columns 63 are fixedly installed on the bottom of the outer frame 61. The positioning columns 63 are arranged in the container 5 and abut against the inner wall of the container 5. The positioning columns 63 can prevent the operator from accidentally touching the sieve plate 6 and causing it to detach from the container 5.

[0027] Furthermore, a screen 62 is fixed inside the outer frame 61 . The screen 62 is used to place tablets. The screen 62 is concave to prevent particles formed during the disintegration process of the tablets from rolling outward along the screen 62 .

[0028] In this embodiment, the dropper 4 is fixed to the connecting rod 3 by the clamp 31, and then the height of the dropper 4 is adjusted by the adjusting member 2, and the regulating valve 41 is opened, and the dropper 4 drips the liquid medium onto the tablet placed at the center of the screen 62. After the liquid medium infiltrates the tablet, the excess liquid is promptly discharged into the container 5 through the screen 62, so as to ensure that the amount of liquid medium contacted by the tablet sample is stable, so that the tablet sample with a faster disintegration speed is not easy to completely dissolve in a short time, so that the operator can observe the disintegration phenomenon occurring during the infiltration process of the tablet sample, and evaluate the size of the disintegrated particles by observing the passing rate of the particles generated after the tablet sample is crushed in the screen 62, so as to facilitate the analysis of the tablet sample by the operator and provide more information for research and development.

[0029] In the present application, the sieve plate 6 with different mesh 62 apertures can be replaced as needed, and different dropper tubes 4 can be replaced according to the size of the tablet to achieve different dripping speeds. The disintegration ability of the tablet samples can be observed and compared by adjusting the dripping speed.

[0030] In addition, the inventors found that for granular medicines, the disintegration method of tablets in the prior art is used to make the contact area between the granular medicine and the liquid medium larger, making it easier and faster to dissolve in the liquid medium. The tablet disintegration equipment in the present application is also suitable for the disintegration of granular medicines. The excess liquid medium dripping is discharged through the screen 62, which is conducive to the observation of the disintegration of the granular medicine.

[0031] Working principle: The dropper 4 is fixed on the connecting rod 3 by the clamp 31, and then the height of the dropper 4 is adjusted by the adjusting member 2. The regulating valve 41 is opened, and the dropper 4 drips the liquid medium onto the tablet placed at the center of the screen 62. After the liquid medium infiltrates the tablet, the excess liquid is discharged into the container 5 in time through the screen 62. The operator observes the disintegration phenomenon occurring during the infiltration process of the tablet sample, and evaluates the size of the disintegrated particles by observing the passing rate of the particles generated after the tablet sample is crushed in the screen 62.

[0032] In summary, although the embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A tablet disintegration device, characterized in that: include: A container (5), wherein a sieve tray (6) is detachably provided on the top of the container (5), wherein the sieve tray (6) comprises a concave sieve (62), and the sieve (62) is used to place tablets; A height-adjustable drip tube (4) with scale is arranged above the screen (62), and the drip tube (4) is used to drip liquid medium onto the tablet.

2. A tablet disintegration device according to claim 1, characterized in that: The sieve plate (6) further comprises an outer frame (61), and the sieve (62) is fixed inside the outer frame (61).

3. A tablet disintegration device according to claim 2, characterized in that: The outer diameter of the outer frame (61) is greater than the outer diameter of the container (5).

4. A tablet disintegration device according to claim 2, characterized in that: At least two positioning columns (63) are fixedly mounted on the bottom of the outer frame (61); the positioning columns (63) are arranged in the container (5) and abut against the inner wall of the container (5).

5. A tablet disintegration device according to claim 1, characterized in that: It also comprises an iron frame (1), on which an adjustment member (2) is arranged.

6. A tablet disintegration device according to claim 5, characterized in that: The adjusting member (2) comprises a fitting portion (21), and the fitting portion (21) extends to one side to form two fixing portions (22).

7. A tablet disintegration device according to claim 6, characterized in that: The fixing portion (22) fixes the fitting portion (21) to the iron frame (1) via bolts.

8. A tablet disintegration device according to claim 7, characterized in that: The fitting portion (21) is fixedly mounted with a connecting rod (3), and the drip tube (4) passes through the connecting rod (3).

9. A tablet disintegration device according to claim 8, characterized in that: The connecting rod (3) is provided with a clamp (31), and the clamp (31) is used to clamp the drip tube (4).

10. A tablet disintegration device according to claim 1, characterized in that: The drip tube (4) is provided with a regulating valve (41).

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