Liquid pumping device for nucleic acid synthesizer

Abstract

The utility model discloses a liquid extracting device for a nucleic acid synthesizer, which belongs to the technical field of biomedical equipment and comprises a synthesizer, a cleaning component is arranged on one side of the synthesizer, a liquid collecting cylinder is arranged on the lower portion inside the synthesizer, a pressure pump is arranged at one end of the liquid collecting cylinder, and a convenient dismounting component is arranged at one end of the pressure pump. According to the liquid collecting device, the disassembling and assembling base, the connecting pipe, the sealing gasket, the clamping block, the pull rod and the first fixing spring are arranged, so that the collecting barrel can be rapidly disassembled and assembled, the structure is disassembled and assembled in an up-down mode, the structure is simple, the structure is convenient to operate, and the cost is low. According to the liquid collecting device, a supporting rod, a fixing base, a fixing rod, a fixing block, a fixing sliding block and a second fixing spring are arranged, and the position of a rotating rod can be conveniently limited after the collecting barrel is overturned through an overturning assembly.

Description

Technical Field

[0001] The utility model belongs to the technical field of biomedical equipment, and in particular relates to a liquid extraction device for a nucleic acid synthesizer. Background Art

[0002] Nucleic acid synthesizer is a high-tech instrument that can synthesize various nucleic acid sequences quickly and accurately, providing strong support for research in biology, medicine, biotechnology and other fields. The instrument has the characteristics of high sensitivity, high resolution and high throughput, and can complete a large number of nucleic acid synthesis tasks in a short time. The liquid extraction device of the nucleic acid synthesizer is an important part of the nucleic acid synthesizer. It is mainly used to extract the liquid in the reaction pool for the next step of processing or analysis.

[0003] Chinese patent application No. 202321781835.6 discloses a liquid extraction device for a DNA synthesizer, including a base plate, a synthesizer is installed on the base plate, and a plurality of liquid collecting holes are provided on the top of the synthesizer, a synthesis chamber is provided in the inner cavity of the synthesizer, a liquid collecting cylinder is rotatably connected to the bottom of the synthesis chamber, a plurality of through holes are provided on one side of the liquid collecting cylinder, and a rotating assembly is provided on the right side of the liquid collecting cylinder, a suction pump is installed on the lower surface of the base plate, a liquid inlet of the suction pump is rotatably connected to the liquid collecting cylinder through a liquid extraction pipe, and a liquid outlet of the suction pump is connected to the collecting cylinder through a pipe thread, a water storage tank is installed on the rear side of the synthesizer, the water storage tank is connected to a water pump through a pipe, and the water outlet of the water pump is connected to two groups of water outlet pipes, and a cleaning structure is provided at the bottom of the two groups of water outlet pipes, so as to realize rapid liquid extraction of the nucleic acid synthesizer, and can clean the liquid remaining in the synthesis chamber and the inner wall of the liquid collecting cylinder to avoid the residual synthetic liquid affecting the synthesis effect of the next liquid.

[0004] The above-mentioned patent disclosed, 1. When in use, the collecting tube is connected by a threaded connection so as to facilitate the disassembly and assembly of the collecting tube, but when in use, the disassembly and assembly of the collecting tube is not convenient enough, and the internal liquid may easily flow out when the collecting tube is disassembled and assembled; 2. When in use, the collecting tube is rotated and adjusted by a hand wheel, but when in use, it is inconvenient to limit the rotating rod of the hand wheel, and the stability after rotation is not high enough. Utility Model Content

[0005] In order to solve the problems raised in the above background technology, the utility model provides a liquid extraction device for a nucleic acid synthesizer, which can quickly disassemble and assemble the collection cylinder, facilitate the rotation of the liquid collection cylinder, and limit the rotating rod of the handwheel, thereby improving the stability after rotation.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a liquid extraction device for a nucleic acid synthesizer, comprising a synthesizer, a cleaning component is arranged on one side of the synthesizer, a liquid collecting cylinder is arranged at the lower part of the synthesizer, a suction pump is arranged at one end of the liquid collecting cylinder, a convenient disassembly and assembly component is arranged at one end of the suction and pressure pump, a collecting cylinder is arranged below the convenient disassembly and assembly component, a flipping component is arranged at the other end of the liquid collecting cylinder, and a limit position component is arranged at the rotating rod of the flipping component.

[0007] Preferably, the convenient disassembly and assembly component includes a disassembly and assembly seat, a connecting pipe, a sealing gasket, a block, a pull rod and a fixing spring, wherein a disassembly and assembly seat is provided at one end of the suction pump, a connecting pipe is inserted below the disassembly and assembly seat, a sealing gasket is provided at the connection between the disassembly and assembly seat and the connecting pipe, a block is provided at one side of the connecting pipe, a pull rod is provided at one end of the block, and a fixing spring is provided below the pull rod.

[0008] Preferably, the upper part of the pull rod abuts against a limit rod, one end of the limit rod is provided with a ball, one side of the limit rod is provided with a limit slider, and the middle of the limit slider slides with the limit rod.

[0009] Preferably, a positioning block is provided on one side of the connecting pipe away from the clamping block, and a positioning groove cooperating with the positioning block is provided inside the disassembly and assembly seat.

[0010] Preferably, the limiting assembly includes a support rod, a fixed seat, a fixed rod, a fixed block, a fixed slide block and two fixed springs, wherein the support rods are symmetrically arranged at the rotating rod of the flip assembly, a fixed seat is arranged below the rotating rod of the flip assembly, a fixed rod is arranged inside the fixed seat, a fixed block is arranged at one end of the fixed rod, a fixed slide block is arranged at one side of the fixed rod, and two fixed springs are arranged below the fixed slide block.

[0011] Preferably, a fixing hole cooperating with the fixing block is opened at one end of the support rod, and a stabilizing sliding rod is slidably disposed at one end of the fixed sliding block.

[0012] Compared with the prior art, the beneficial effects of the utility model are:

[0013] 1. The utility model realizes the effect of quickly disassembling and assembling the collecting barrel by setting up a convenient disassembly and assembly component. A disassembly and assembly seat, a connecting pipe, a sealing gasket, a clamping block, a pull rod and a fixing spring are provided, so that the collecting barrel can be quickly disassembled and assembled. The structure is disassembled and assembled in an up and down manner, which will not cause the liquid in the collecting barrel to leak out. A limit rod, a ball, a limit sliding block and a limit sliding rod are provided, so that after the clamping block is pulled out, the clamping block can be limited to prevent it from rebounding.

[0014] 2. The utility model sets a limit component, so that after the liquid collecting cylinder is rotated, the turning rod of the hand wheel can be limited, thereby improving the stability after rotation. A support rod, a fixed seat, a fixed rod, a fixed block, a fixed slider and a fixed spring are set, so that after the collecting cylinder is flipped over by the flipping component, the turning rod can be limited, thereby improving the stability after flipping. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0016] Figure 2 It is a schematic diagram of the structure of the utility model cut from the front view;

[0017] Figure 3 This is a schematic diagram of the structure of the convenient disassembly and assembly components of the utility model;

[0018] Figure 4 This is a schematic diagram of the structure of the enlarged A position of the convenient disassembly and assembly component of the utility model;

[0019] Figure 5 It is a structural schematic diagram of the limit assembly of the utility model.

[0020] In the figure: 1. synthesizer; 2. cleaning component; 3. liquid collecting cylinder; 4. suction pump; 5. convenient disassembly and assembly component; 51. disassembly and assembly seat; 52. connecting pipe; 53. sealing gasket; 54. clamping block; 55. pull rod; 56. fixing spring one; 551. limiting rod; 552. ball bearing; 553. limiting slider; 554. limiting slider; 6. collecting cylinder; 7. flipping component; 8. limiting component; 81. support rod; 82. fixing seat; 83. fixing rod; 84. fixing block; 85. fixing slider; 86. fixing spring two. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0022] Example 1

[0023] See also Figure 1-5The utility model provides the following technical solutions: a liquid extraction device for a nucleic acid synthesizer, comprising a synthesizer 1, a cleaning component 2 is arranged on one side of the synthesizer 1, a liquid collecting cylinder 3 is arranged at the lower part of the synthesizer 1, a suction pump 4 is arranged at one end of the liquid collecting cylinder 3, a convenient disassembly component 5 is arranged at one end of the suction pump 4, a collecting cylinder 6 is arranged at the lower part of the convenient disassembly component 5, a flip component 7 is arranged at the other end of the liquid collecting cylinder 3, and a limit position component 8 is arranged at the rotating rod of the flip component 7.

[0024] Specifically, the convenient disassembly and assembly component 5 includes a disassembly and assembly seat 51, a connecting pipe 52, a sealing gasket 53, a clamping block 54, a pull rod 55 and a fixing spring 56, wherein a disassembly and assembly seat 51 is provided at one end of the suction pump 4, a connecting pipe 52 is inserted below the disassembly and assembly seat 51, a sealing gasket 53 is provided at the connection between the disassembly and assembly seat 51 and the connecting pipe 52, a clamping block 54 is provided on one side of the connecting pipe 52, a pull rod 55 is provided at one end of the clamping block 54, and a fixing spring 56 is provided below the pull rod 55.

[0025] By adopting the above technical solution, the pull rod 55 is pulled, and the pull rod 55 drives the block 54 to move and compress the fixed spring 56, so that the block 54 is disengaged from the clamping hole, and then the connecting tube 52 and the disassembly seat 51 can be separated, so that the collecting tube 6 can be removed, so that the collecting tube 6 can be quickly disassembled and assembled when the device is in use, and the structure can be disassembled and assembled in an up and down manner, which will not cause the liquid in the collecting tube 6 to leak out, thereby improving the convenience of use.

[0026] Specifically, the upper part of the pull rod 55 abuts against a limit rod 551 , one end of the limit rod 551 is provided with a ball 552 , one side of the limit rod 551 is provided with a limit slider 553 , and a limit slider 554 slides in the middle of the limit slider 553 .

[0027] By adopting the above technical solution, when the block 54 moves to the limit hole and overlaps with the limit rod 551, the limit rod 551 moves downward to limit the block 54 to prevent it from rebounding, and the ball 552 facilitates smooth sliding between the limit rod 551, the pull rod 55 and the block 54.

[0028] Specifically, a positioning block is provided on one side of the connecting pipe 52 away from the clamping block 54 , and a positioning groove cooperating with the positioning block is provided inside the disassembly and assembly seat 51 .

[0029] By adopting the above technical solution, the positioning block and the positioning groove cooperate with each other, so that the connecting pipe 52 can be positioned conveniently when the connecting pipe 52 is installed.

[0030] When the present embodiment is in use: the pull rod 55 is pulled, and the pull rod 55 drives the block 54 to move and compress the fixed spring 56, so that the block 54 is disengaged from the clamping hole. When the block 54 moves to the limiting hole and coincides with the limiting rod 551, the limiting rod 551 moves downward to limit the block 54 to prevent it from rebounding. The ball 552 facilitates smooth sliding between the limiting rod 551, the pull rod 55 and the block 54. Then the connecting tube 52 and the disassembly and assembly seat 51 can be separated, so that the collecting tube 6 can be removed, so that the collecting tube 6 can be quickly disassembled and assembled when the device is in use. Moreover, the structure is disassembled and assembled in an up and down manner, which does not cause the liquid in the collecting tube 6 to leak out, thereby improving the convenience of use.

[0031] Example 2

[0032] The difference between this embodiment and embodiment 1 lies in that: specifically, the limiting assembly 8 includes a support rod 81, a fixed seat 82, a fixed rod 83, a fixed block 84, a fixed slide block 85 and a second fixed spring 86, wherein the support rods 81 are symmetrically arranged at the rotating rod of the flip assembly 7, a fixed seat 82 is arranged below the rotating rod of the flip assembly 7, a fixed rod 83 is arranged inside the fixed seat 82, a fixed block 84 is arranged at one end of the fixed rod 83, a fixed slide block 85 is arranged on one side of the fixed rod 83, and a second fixed spring 86 is arranged below the fixed slide block 85.

[0033] By adopting the above technical solution, the fixing rod 83 is pulled, and the fixing rod 83 drives the fixing slider 85 to move and compress the fixing spring 2 86, so that the fixing block 84 is disengaged from the fixing hole, and then the flipping component 7 drives the liquid collecting tube 3 to flip. After the flipping is completed, the fixing rod 83 is loosened, the fixing spring 2 86 is reset, and the fixing block 84 is driven to be inserted into the corresponding fixing hole, and the rotating rod of the flipping component 7 is fixed, so that when the device is in use, it is convenient to flip the liquid collecting tube 3 through the flipping component 7, and the rotating rod can be limited to improve the stability after flipping.

[0034] Specifically, a fixing hole matching the fixing block 84 is formed at one end of the support rod 81 , and a stabilizing slide bar is slidably disposed at one end of the fixing slide block 85 .

[0035] By adopting the above technical solution, the fixing hole facilitates the insertion of the fixing block 84 to fix the support rod 81, thereby fixing the rotating rod of the flip assembly 7, and the stabilizing slide bar facilitates the stable sliding of the fixed slide block 85.

[0036] When this embodiment is in use: pull the fixing rod 83, the fixing rod 83 drives the fixing slide block 85 to move and compress the fixing spring 2 86, so that the fixing block 84 is disengaged from the fixing hole, and then the flip assembly 7 drives the liquid collecting tube 3 to flip. After the flipping is completed, release the fixing rod 83, the fixing spring 2 86 is reset, and drives the fixing block 84 to be inserted into the corresponding fixing hole, and fix the rotating rod of the flip assembly 7, so that when the device is in use, it is convenient to limit the rotating rod after the liquid collecting tube 3 is flipped by the flip assembly 7, thereby improving the stability after flipping.

[0037] The structure and use principle of the synthesizer 1, cleaning component 2 and flip component 7 in the utility model have been disclosed in a liquid extraction device for a DNA synthesizer disclosed in Chinese patent application No. 202321781835.6. Its working principle is to inject reagents into multiple groups of liquid collecting holes on the synthesizer 1 according to specific chemical reaction steps. After the reagents are injected, the multiple reagents in each hole react in turn in the synthesis chamber to obtain a synthetic product. At this time, the through hole at the bottom of the liquid collecting barrel 3 is located at the bottom, that is, the liquid collecting barrel 3 is not connected to the synthesis chamber. When the synthesized reagent or synthetic liquid needs to be extracted, the liquid collecting barrel 3 can be driven to rotate through the work of the rotating component, so that the top of the through hole is facing the synthesis chamber, and the synthesis chamber is connected to the liquid collecting barrel 3, and then the suction pump 4 is started. The suction pump 4 works to extract The liquid pipe generates suction, and then discharges the liquid synthesized in the liquid collecting tube 3 and the synthesis chamber, thereby realizing rapid liquid extraction from the nucleic acid synthesizer, and collecting the liquid in the collecting tube 6 to facilitate subsequent processing. After the liquid extraction is completed, cleaning liquid or water is added to the water storage tank, and the water or cleaning liquid in the water storage tank is transported to the cleaning structure through the operation of the water pump. At this time, the through hole is connected with the synthesis chamber, so that the synthesis chamber and the inner wall of the liquid collecting tube 3 are quickly cleaned, and the cleaned liquid is discharged through the suction pump 4. The cleaning method is simple, and the residual synthetic liquid is prevented from affecting the synthesis effect of the next liquid. By rotating the hand wheel, the rotating rod and the driving gear can be driven to rotate forward or reverse. Since the driving gear is meshed with the driven gear, the liquid collecting tube 3 can be driven to rotate, so that the through hole is connected or disconnected with the synthesis chamber.

[0038] The working principle and use process of the utility model: when the utility model is used, the reagents are injected into the multiple groups of liquid collecting holes on the synthesizer 1 according to specific chemical reaction steps. After the reagents are injected, the multiple reagents in each hole react in the synthesis chamber in turn to obtain a synthetic product, and then the suction pump 4 is started and restarted. The suction pump 4 works, so that the liquid extraction tube generates suction, and then the liquid synthesized in the liquid collecting tube 3 and the synthesis chamber is discharged, thereby realizing the rapid liquid extraction of the nucleic acid synthesizer, and the liquid is collected in the collection tube 6. After the extraction is completed, the collection tube 6 can be quickly removed through the convenient disassembly and assembly component 5. After use, the liquid collecting tube 3 is flipped through the flipping component 7, and the rotating rod of the flipping component 7 is fixed by the limiting component 8. Then, the inside of the synthesizer 1 is cleaned through the cleaning component 2. When the convenient disassembly and assembly component 5 is in use, the pull rod 55 is pulled, and the pull rod 55 drives the clamping block 54 to move and compress the fixing spring 56, so that the clamping block 54 is separated from the clamping hole. When the clamping block 54 moves to the limiting hole and the limiting rod 551 overlaps The limit rod 551 moves downward to limit the block 54 to prevent it from rebounding, and the ball 552 facilitates the smooth sliding between the limit rod 551, the pull rod 55 and the block 54, and then the connecting tube 52 and the disassembly seat 51 can be separated, so that the collecting tube 6 can be removed, so that the device can quickly disassemble and assemble the collecting tube 6 when in use, and the structure is disassembled and assembled in an up and down manner, which does not cause the liquid in the collecting tube 6 to leak out, thereby improving the convenience of use. When the limit assembly 8 is in use, the fixing rod 83 is pulled, and the fixing rod 83 drives the fixing slider 85 to move and compress the fixing spring 2 86, so that the fixing block 84 is disengaged from the fixing hole, and then the flip assembly 7 drives the liquid collecting tube 3 to flip. After the flip is completed, the fixing rod 83 is released, the fixing spring 2 86 is reset, and the fixing block 84 is driven to insert into the corresponding fixing hole, and the rotating rod of the flip assembly 7 is fixed, so that when the device is in use, it is convenient to flip the liquid collecting tube 3 through the flip assembly 7, and the rotating rod can be limited, thereby improving the stability after flipping.

[0039] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A liquid extraction device for a nucleic acid synthesizer, comprising a synthesizer, characterized in that: A cleaning component is provided on one side of the synthesizer, a liquid collecting cylinder is provided at the lower part of the synthesizer, a suction pump is provided at one end of the liquid collecting cylinder, a convenient disassembly and assembly component is provided at one end of the suction and assembly pump, a collecting cylinder is provided at the lower part of the convenient disassembly and assembly component, a flipping component is provided at the other end of the liquid collecting cylinder, and a limiting component is provided at the rotating rod of the flipping component.

2. A liquid extraction device for a nucleic acid synthesizer according to claim 1, characterized in that: The convenient disassembly and assembly component includes a disassembly and assembly seat, a connecting pipe, a sealing gasket, a clamping block, a pull rod and a fixing spring, wherein a disassembly and assembly seat is provided at one end of the suction pump, a connecting pipe is inserted below the disassembly and assembly seat, a sealing gasket is provided at the connection between the disassembly and assembly seat and the connecting pipe, a clamping block is provided on one side of the connecting pipe, a pull rod is provided at one end of the clamping block, and a fixing spring is provided below the pull rod.

3. A liquid extraction device for a nucleic acid synthesizer according to claim 2, characterized in that: The upper part of the pull rod abuts against a limit rod, one end of the limit rod is provided with a ball, one side of the limit rod is provided with a limit slider, and the middle of the limit slider slides with the limit slider.

4. A liquid extraction device for a nucleic acid synthesizer according to claim 2, characterized in that: A positioning block is arranged on one side of the connecting pipe away from the clamping block, and a positioning groove cooperating with the positioning block is arranged inside the disassembly and assembly seat.

5. A liquid extraction device for a nucleic acid synthesizer according to claim 1, characterized in that: The limiting assembly includes a support rod, a fixed seat, a fixed rod, a fixed block, a fixed slider and two fixed springs, wherein the support rods are symmetrically arranged at the rotating rod of the flip assembly, a fixed seat is arranged below the rotating rod of the flip assembly, a fixed rod is arranged inside the fixed seat, a fixed block is arranged at one end of the fixed rod, a fixed slider is arranged on one side of the fixed rod, and two fixed springs are arranged below the fixed slider.

6. A liquid extraction device for a nucleic acid synthesizer according to claim 5, characterized in that: One end of the support rod is provided with a fixing hole matched with the fixing block, and one end of the fixed sliding block is slidably provided with a stabilizing sliding bar.

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