Production system for refining inositol

Abstract

The utility model relates to the technical field of inositol, in particular to a production system for refining inositol, which comprises nanofiltration membrane concentration equipment communicated with an inositol solution conveying pipeline, a permeate outlet of the nanofiltration membrane concentration equipment is communicated with a neutralization kettle, a discharge port of the neutralization kettle is communicated with a filter device, a liquid outlet of the filter device is communicated with a cationic resin column, and the cation resin column is communicated with a liquid outlet of the nanofiltration membrane concentration equipment. A discharge port of the cation resin column is communicated with the anion resin column, a discharge port of the anion resin column is communicated with the reverse osmosis membrane equipment, a concentrated solution outlet of the reverse osmosis membrane equipment is communicated with the concentrator, a concentrated solution outlet of the concentrator is communicated with the crystallization kettle, a discharge port of the crystallization kettle is communicated with the centrifugal machine, and a discharge port of the centrifugal machine is communicated with the drying device. And a discharge hole of the drying device is communicated with a product storage tank. The production system for refining the inositol is reasonable in design, impurities in the inositol solution can be effectively removed, the use amount of resin is reduced, and the yield and the purity of the inositol are greatly improved.

Description

Technical Field

[0001] The utility model relates to the technical field of inositol, in particular to a production system for refining inositol. Background Art

[0002] Inositol, chemical name: cyclohexanehexol, is an important vitamin required by higher animals. Inositol can promote fat metabolism and reduce the cholesterol content in the blood. It is also used as an anti-fatty liver drug for the treatment of cirrhosis, hepatitis, high cholesterol, excessive fat and vascular sclerosis. In addition to being used directly as a drug, such as inositol tablets, hepatol, and liver-soothing tablets, inositol is also used as a pharmaceutical intermediate to make many drugs, such as nicotinic acid inositol ester, Maitong, and the anticancer drug paclitaxel.

[0003] Traditional inositol production processes mostly use calcium phytate as raw material, and when producing inositol, tricalcium phosphate is produced as a byproduct. In recent years, the production of inositol using potassium phytate as raw material has become increasingly popular. Compared with traditional processes, its byproduct potassium dihydrogen phosphate has a wide range of uses, high added value, and better economic benefits. Its production process generally includes processes such as hydrolysis, filtration, simulated moving bed chromatography, concentration, crude crystallization, decolorization, recrystallization, centrifugation, and drying. Although the byproduct potassium dihydrogen phosphate is of high value, due to its large solubility in water, the hydrolysis rate of potassium phytate is lower than that of calcium phytate, and potassium phytate that is not thoroughly hydrolyzed is easily retained in the product, affecting product quality and yield. Therefore, in view of the above-mentioned technical problems, it is necessary to develop a production system for refining inositol. Utility Model Content

[0004] The technical problem to be solved by the utility model is: in view of the deficiencies of the prior art, a production system for refining inositol is provided, and the yield and quality of inositol are greatly improved by utilizing the production system.

[0005] In order to solve the above technical problems, the technical solution of the utility model is:

[0006] A production system for refining inositol comprises a nanofiltration membrane concentration device connected to an inositol solution conveying pipeline, wherein the permeate outlet of the nanofiltration membrane concentration device is connected to a neutralization kettle, the discharge port of the neutralization kettle is connected to a filtering device, the liquid outlet of the filtering device is connected to a cation resin column, the discharge port of the cation resin column is connected to an anion resin column, the discharge port of the anion resin column is connected to a reverse osmosis membrane device, the concentrated liquid outlet of the reverse osmosis membrane device is connected to a concentrator, the concentrated liquid outlet of the concentrator is connected to a crystallization kettle, the discharge port of the crystallization kettle is connected to a centrifuge, the discharge port of the centrifuge is connected to a drying device, and the discharge port of the drying device is connected to a product storage tank.

[0007] As an improved technical solution, the molecular weight cutoff of the nanofiltration membrane in the nanofiltration membrane concentration device is 500-1000Da, and the concentrated liquid outlet of the nanofiltration membrane concentration device is connected to the concentrated liquid storage tank.

[0008] As an improved technical solution, the neutralization kettle includes a main body, a liquid inlet and a neutralizer inlet are provided on the top of the main body, a discharge port is provided on the bottom of the main body, a stirring shaft is provided inside the main body, one end of the stirring shaft is connected to a motor, and the stirring shaft is provided with a first stirring component, a second stirring component and a third stirring component from top to bottom.

[0009] As an improved technical solution, the first stirring component is a stirring plate arranged on both sides of the upper part of the stirring shaft, and a plurality of auxiliary stirring blocks are provided on the stirring plate; the second stirring component is a stirring rod arranged on both sides of the middle part of the stirring shaft, and a plurality of stirring teeth are provided on the stirring rod; the third stirring component is an arc-shaped stirring plate arranged at the bottom of the stirring shaft, and a plurality of stirring rods are provided on the arc-shaped stirring plate.

[0010] As an improved technical solution, the interior of the cationic resin column is filled with gel-type cationic exchange resin 001*16, and the interior of the anionic resin column is filled with macroporous anionic exchange resin LX-600J.

[0011] As an improved technical solution, the filtering device is a plate and frame filter with a filter cloth aperture of 400-600 mesh.

[0012] As an improved technical solution, the drying device is a vibrating fluidized bed.

[0013] After adopting the above technical solution, the beneficial effects of the utility model are:

[0014] The production system for refining inositol includes a nanofiltration membrane concentration device connected to an inositol solution delivery pipeline, the permeate outlet of the nanofiltration membrane concentration device is connected to a neutralization kettle, the discharge port of the neutralization kettle is connected to a filtering device, the liquid outlet of the filtering device is connected to a cationic resin column, the discharge port of the cationic resin column is connected to an anionic resin column, the discharge port of the anionic resin column is connected to a reverse osmosis membrane device, the concentrated liquid outlet of the reverse osmosis membrane device is connected to a concentrator, the concentrated liquid outlet is connected to a crystallization kettle, the discharge port of the crystallization kettle is connected to a centrifuge, the discharge port of the centrifuge is connected to a drying device, and the discharge port of the drying device is connected to a product storage tank. In actual production, the salt-containing inositol solution collected after the treatment of the simulated moving bed chromatographic separation system enters the first nanofiltration membrane device through the inositol solution delivery pipeline, the permeate collected after the treatment enters the neutralization kettle, and then a neutralizer is added, the feed liquid after the neutralization reaction enters the inside of the filter device, the filtrate collected after filtration enters the cationic resin column, the effluent collected enters the inside of the anionic resin column, the effluent collected enters the reverse osmosis membrane device, the concentrated solution collected enters the concentrator for further concentration, the concentrated solution enters the inside of the crystallization kettle, the material after cooling crystallization enters the inside of the centrifuge, the inositol wet product after centrifugation enters the drying device (vibrating fluidized bed) through an auger, and the dried inositol product is collected in a product storage tank. The above-mentioned production system for refining inositol is reasonably designed, can effectively remove impurities in the inositol solution, reduces the amount of resin used, and greatly improves the yield and purity of inositol.

[0015] Since the molecular weight cutoff of the nanofiltration membrane in the nanofiltration membrane concentration device is 500-1000Da, the concentrated liquid outlet of the nanofiltration membrane concentration device is connected to the concentrated liquid storage tank. The nanofiltration membrane device with the above molecular weight cutoff facilitates the permeate component containing inositol to pass through, and the concentrated liquid collected in the concentrated liquid storage tank is returned to the hydrolysis process.

[0016] Since the neutralization kettle includes a body, a liquid inlet and a neutralizer inlet are provided at the top of the body, a material outlet is provided at the bottom of the body, a stirring shaft is provided inside the body, one end of the stirring shaft is connected to a motor, and the stirring shaft is provided with a first stirring component, a second stirring component and a third stirring component from top to bottom. In actual production, the permeate and the neutralizer (calcium salt) enter the inside of the body respectively, and after the motor is started, the stirring shaft, the first, second and third stirring components are driven to stir and mix the permeate and the neutralizer, thereby promoting the neutralization reaction.

[0017] Since the first stirring component is a stirring plate arranged on both sides of the upper part of the stirring shaft, and a plurality of auxiliary stirring blocks are arranged on the stirring plate; the second stirring component is a stirring rod arranged on both sides of the middle part of the stirring shaft, and a plurality of stirring teeth are arranged on the stirring rod; the third stirring component is an arc-shaped stirring plate arranged at the bottom of the stirring shaft, and a plurality of stirring rods are arranged on the arc-shaped stirring plate. In actual production, the motor drives the stirring shaft to rotate, the stirring plate and the auxiliary stirring block of the first stirring component stir and mix the neutralizer and the feed liquid in the upper part, the stirring rod and the plurality of stirring teeth of the second stirring component stir and mix the neutralizer and the feed liquid in the middle part, the arc-shaped stirring plate and the plurality of stirring rods stir and mix the neutralizer and the feed liquid at the bottom, and the first, second and third stirring components work together to stir and mix the neutralizer and the feed liquid, thereby promoting the neutralization reaction.

[0018] Since the interior of the cation resin column is filled with gel-type cation exchange resin 001*16, and the interior of the anion resin column is filled with macroporous anion exchange resin LX-600J, the cation resin column and anion resin column with the above fillers can effectively remove metal ions and pigments.

[0019] Since the filtering device is a plate-and-frame filter with a filter cloth aperture of 400-600 mesh, the plate-and-frame filter with the molecular weight cut-off is convenient for the filtrate containing inositol to pass through. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the structure of a production system for refining inositol according to the utility model;

[0021] Among them, 1-inositol solution delivery pipeline, 2-nanofiltration membrane concentration equipment, 3-neutralization kettle, 30-first stirring component, 300-stirring plate, 301-auxiliary stirring block, 31-second stirring component, 310-stirring rod, 311-stirring teeth, 32-third stirring component, 320-arc stirring plate, 321-stirring rod, 4-filtration device, 5-cationic resin column, 6-anion resin column, 7-reverse osmosis membrane equipment, 8-concentrator, 9-crystallization kettle, 10-centrifuge, 11-drying device, 12-product storage tank, 13-concentrate storage tank. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical solution and advantages of the utility model more clear, the utility model is further described in detail in combination with the embodiments below. It should be understood that the specific embodiments described here are only used to explain the utility model, and are not used to limit the utility model.

[0023] A production system for refining inositol, such as Figure 1As shown, it includes a nanofiltration membrane concentration device 2 connected to an inositol solution delivery pipeline 1, the permeate outlet of the nanofiltration membrane concentration device 2 is connected to a neutralization kettle 3, the discharge port of the neutralization kettle 3 is connected to a filter device 4 (a plate-and-frame filter with a filter cloth aperture of 400-600 mesh), the liquid outlet of the filter device 4 is connected to a cationic resin column 5, the discharge port of the cationic resin column 5 is connected to an anionic resin column 6, the discharge port of the anionic resin column 6 is connected to a reverse osmosis membrane device 7, the concentrated liquid outlet of the reverse osmosis membrane device 7 is connected to a concentrator 8 (a triple-effect concentrator), the concentrated liquid outlet of the concentrator 8 is connected to a crystallization kettle 9, the discharge port of the crystallization kettle 9 is connected to a centrifuge 10, the discharge port of the centrifuge 10 is connected to a drying device 11 (a vibrating fluidized bed), and the discharge port of the drying device 11 is connected to a product storage tank 12.

[0024] In actual production, the salt-containing inositol solution collected after treatment by the simulated moving bed chromatographic separation system enters the first nanofiltration membrane device through the inositol solution delivery pipeline, the permeate collected after treatment enters the neutralization kettle, and then a neutralizer is added, the feed liquid after neutralization reaction enters the inside of the filter device, the filtrate collected after filtration enters the cationic resin column, the collected effluent enters the inside of the anionic resin column, the collected effluent enters the reverse osmosis membrane device, the collected concentrated solution enters the concentrator for further concentration, the concentrated solution enters the inside of the crystallization kettle, the material after cooling and crystallization enters the inside of the centrifuge, the inositol wet product after centrifugation enters the drying device through an auger, and the dried inositol product is collected in a product storage tank. The above-mentioned production system for inositol refining is reasonably designed, can effectively remove impurities in the inositol solution, reduces the amount of resin used, and greatly improves the yield and purity of inositol.

[0025] The nanofiltration membrane in the nanofiltration membrane concentration device 2 has a molecular weight cutoff of 500-1000Da, and the concentrated liquid outlet of the nanofiltration membrane concentration device is connected to the concentrated liquid storage tank 13. The nanofiltration membrane device with the above molecular weight cutoff facilitates the permeate component containing inositol to pass through, and the concentrated liquid collected in the concentrated liquid storage tank is returned to the hydrolysis process.

[0026] The neutralization kettle 3 includes a body, a liquid inlet and a neutralizing agent inlet are provided at the top of the body, a material outlet is provided at the bottom of the body, a stirring shaft is provided inside the body, one end of the stirring shaft is connected to a motor, and the stirring shaft is provided with a first stirring member 30, a second stirring member 31 and a third stirring member 32 in order from top to bottom. In actual production, the permeate and the neutralizing agent (calcium salt) enter the body respectively, and after the motor is started, the stirring shaft, the first, second and third stirring members are driven to stir and mix the permeate and the neutralizing agent to promote the neutralization reaction.

[0027] The first stirring member 30 is a stirring plate 300 disposed on both sides of the upper part of the stirring shaft, and a plurality of auxiliary stirring blocks 301 are disposed on the stirring plate 300; the second stirring member 31 is a stirring rod 310 disposed on both sides of the middle part of the stirring shaft, and a plurality of stirring teeth 311 are disposed on the stirring rod 310; the third stirring member 32 is an arc-shaped stirring plate 320 disposed at the bottom of the stirring shaft, and a plurality of stirring rods 321 are disposed on the arc-shaped stirring plate 320. In actual production, the motor drives the stirring shaft to rotate, the stirring plate and the auxiliary stirring blocks of the first stirring member stir and mix the neutralizer and the feed liquid at the upper part, the stirring rod and the plurality of stirring teeth of the second stirring member stir and mix the neutralizer and the feed liquid in the middle part, the arc-shaped stirring plate and the plurality of stirring rods stir and mix the neutralizer and the feed liquid at the bottom, and the first, second and third stirring members work together to stir and mix the neutralizer and the feed liquid, thereby promoting the neutralization reaction.

[0028] The interior of the cation resin column 5 is filled with gel-type cation exchange resin 001*16, and the interior of the anion resin column 6 is filled with macroporous anion exchange resin LX-600J. The cation resin column and anion resin column with the above fillers can effectively remove metal ions and pigments.

[0029] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A production system for refining inositol, characterized in that: The invention comprises a nanofiltration membrane concentration device connected with an inositol solution conveying pipeline, wherein the permeate outlet of the nanofiltration membrane concentration device is connected with a neutralization kettle, the discharge port of the neutralization kettle is connected with a filtering device, the liquid outlet of the filtering device is connected with a cation resin column, the discharge port of the cation resin column is connected with an anion resin column, the discharge port of the anion resin column is connected with a reverse osmosis membrane device, the concentrated liquid outlet of the reverse osmosis membrane device is connected with a concentrator, the concentrated liquid outlet of the concentrator is connected with a crystallization kettle, the discharge port of the crystallization kettle is connected with a centrifuge, the discharge port of the centrifuge is connected with a drying device, and the discharge port of the drying device is connected with a product storage tank.

2. A production system for refining inositol according to claim 1, characterized in that: The nanofiltration membrane in the nanofiltration membrane concentration device has a molecular weight cutoff of 500-1000Da, and the concentrated liquid outlet of the nanofiltration membrane concentration device is connected to a concentrated liquid storage tank.

3. A production system for refining inositol according to claim 1, characterized in that: The neutralization kettle comprises a main body, a liquid inlet and a neutralizing agent inlet are provided on the top of the main body, a discharge port is provided on the bottom of the main body, a stirring shaft is provided inside the main body, one end of the stirring shaft is connected to a motor, and the stirring shaft is provided with a first stirring component, a second stirring component and a third stirring component in sequence from top to bottom.

4. A production system for refining inositol according to claim 3, characterized in that: The first stirring component is a stirring plate arranged on both sides of the upper part of the stirring shaft, and a plurality of auxiliary stirring blocks are arranged on the stirring plate; the second stirring component is a stirring rod arranged on both sides of the middle part of the stirring shaft, and a plurality of stirring teeth are arranged on the stirring rod; the third stirring component is an arc-shaped stirring plate arranged at the bottom of the stirring shaft, and a plurality of stirring rods are arranged on the arc-shaped stirring plate.

5. A production system for refining inositol according to claim 1, characterized in that: The interior of the cationic resin column is filled with gel-type cationic exchange resin 001*16, and the interior of the anionic resin column is filled with macroporous anionic exchange resin LX-600J.

6. A production system for refining inositol according to claim 1, characterized in that: The filtering device is a plate-and-frame filter with a filter cloth aperture of 400-600 meshes.

7. A production system for refining inositol according to claim 1, characterized in that: The drying device is a vibrating fluidized bed.

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