Adsorption-enhanced magnetic separation device

Abstract

The utility model discloses an adsorption enhancement type magnetic separation device, which is characterized in that at least one mounting groove is arranged on a base, an annular magnet used for extending into the bottom of a PCR (Polymerase Chain Reaction) tube is arranged in the mounting groove, one of the inner side wall and the outer side wall of the annular magnet is an N pole, and the other one is an S pole, a support column is arranged on the base, and a mounting cavity is arranged in the support column; a lower magnet and an upper magnet which abut against and attract each other are arranged in the mounting cavity, the supporting frame is arranged on the supporting column, and a positioning hole which corresponds to the annular magnet and is used for positioning the upper portion of the PCR tube is formed in the supporting frame. The magnetic microspheres can be adsorbed to the bottom and the side wall of the PCR tube through the lower magnet and the upper magnet in the supporting column and the annular magnet on the base, so that the adsorption area is enlarged, the adsorption effect is enhanced, sufficient adsorption can be ensured, and the situation that the magnetic microspheres are adsorbed only on the side wall to occupy the transverse space is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of small magnetic separation devices, in particular to an adsorption-enhanced magnetic separation device. Background Art

[0002] In the prior art, after a small-scale experiment, a small separation device such as a magnetic rack can be used to separate the magnetic microspheres and the liquid in the PCR tube, that is, the magnetic microspheres are adsorbed and fixed in the PCR tube by the magnetic rack, and then the liquid is subsequently operated and processed.

[0003] There are many types of small magnetic separation devices (magnetic racks), which are generally used to fix magnetic microspheres on the side walls of PCR tubes by magnetic adsorption parts arranged parallel to the vertical PCR tubes. However, the diameter of the PCR tube is small. If the magnetic microspheres are gathered on the side walls only by lateral adsorption, the lateral space may be affected due to the stacking effect. Based on the above, a magnetic rack with application number 202321360134.5 is disclosed, which discloses a first magnetic adsorption part and a second magnetic adsorption part respectively located on the side walls and bottom walls of the magnetic rack for lateral adsorption and bottom adsorption, respectively. However, it is necessary to arrange multiple first magnetic adsorption parts side by side, which increases the complexity of the structure and installation. In addition, the second magnetic adsorption part can only contact the bottom end of the PCR tube after being arranged, and the magnetic adsorption effect on the bottom of the PCR tube is limited. Utility Model Content

[0004] The utility model aims to provide an adsorption-enhanced magnetic separation device, which can adsorb magnetic microspheres to the bottom and side walls of PCR tubes through the lower magnet and upper magnet in the pillar and the annular magnet on the base, thereby increasing the adsorption area and enhancing the adsorption effect, ensuring sufficient adsorption and avoiding occupation of lateral space due to adsorption only on the side walls.

[0005] In order to achieve the above-mentioned purpose, the technical solution adopted by the utility model is: an adsorption enhanced magnetic separation device, comprising:

[0006] The base is provided with at least one mounting groove, wherein a ring magnet is provided in the mounting groove for extending into the bottom of the PCR tube, wherein one of the inner wall or the outer wall of the ring magnet is an N pole, and the other is an S pole,

[0007] A support column is arranged on the base, wherein a mounting cavity is arranged in the support column, wherein a lower magnet and an upper magnet which abut against and adsorb each other are arranged in the mounting cavity,

[0008] A support frame is arranged on the pillar, and a positioning hole corresponding to the annular magnet and used for positioning the upper part of the PCR tube is provided on the support frame.

[0009] As a further optimization, the pillar includes a column and a base plate, the installation cavity is formed on the column, the diameter of the base plate is larger than the diameter of the column, the two abut against each other and seal the installation cavity; a through hole is provided on the base, the column passes through the through hole, and the base plate abuts against the lower end of the base.

[0010] As a further optimization, the upper magnet is arranged at the upper part of the installation cavity, and the lower magnet is fixed on the base plate and extends into the installation cavity to abut against the upper magnet, so as to facilitate the installation of the base plate and the column, and the forming of the pillar can be completed only by magnetic attraction.

[0011] As a further optimization, a fixing groove is provided on the bottom plate, and the lower part of the lower magnet is arranged in the fixing groove.

[0012] As a further optimization, a limiting groove is provided at the lower end of the base beside the through hole, and the bottom plate is embedded in the limiting groove, so that the base and the lower end surface of the bottom plate can be flush, ensuring the stability of the placement of the magnetic separation device.

[0013] As a further optimization, the bottom plate is a circular structure, which does not intersect with the vertical projection of the positioning hole.

[0014] As a further optimization, at least one positioning plate is provided at the lower portion of the side wall of the column, and an embedding groove connected to the through hole is provided on the base. The positioning plate is embedded in the embedding groove, which can prevent the column from rotating relative to the base and affecting the alignment of the positioning hole and the annular magnet after the pillar and the base are installed.

[0015] As a further optimization, a limiting plate is provided at the upper end of the positioning plate, and the limiting plate abuts against the upper end of the base, so that the base can be positioned on the support.

[0016] As a further optimization, the height of the lower magnet is smaller than the height of the upper magnet, which can generate a stronger magnetic field and magnetic attraction in the middle and lower part of the PCR tube.

[0017] As a further optimization, the number of the positioning holes is four, and the four positioning holes are symmetrically arranged.

[0018] Compared with the prior art, the utility model has the following beneficial effects:

[0019] 1. The magnetic microspheres can be adsorbed to the bottom and side walls of the PCR tube through the lower magnet and upper magnet in the pillar and the annular magnet on the base, which increases the adsorption area and enhances the adsorption effect, ensuring sufficient adsorption and avoiding adsorption only on the side wall to occupy the lateral space;

[0020] 2. The support column adopts the combination of a column and a base plate, which is convenient for installation and positioning with the base, thereby improving the versatility of the magnetic separation device. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a structural diagram of the utility model.

[0022] Figure 2 It is an exploded view of the utility model.

[0023] Figure 3 This is a structural diagram of the pillar and support frame of the utility model.

[0024] Figure 4 This is a bottom perspective structural diagram of the base of the utility model.

[0025] Figure 5 This is a schematic diagram of the installation of a column and a base in another embodiment of the present utility model. DETAILED DESCRIPTION

[0026] The following are specific embodiments of the present invention and the accompanying drawings to further describe the technical solution of the present invention, but the present invention is not limited to these embodiments.

[0027] like Figures 1 to 3 As shown, an adsorption enhanced magnetic separation device includes a base 1, a support 2 and a support frame 3. The base 1 is provided with four mounting grooves 101. The mounting grooves 101 are provided with an annular magnet 41 for extending into the bottom of the PCR tube 5, that is, the bottom of the PCR tube 5 can extend into the central hole 410 of the annular magnet 41. By arranging the annular magnet in the mounting groove 101, it is possible to avoid occupying the space above the base, so that the position of the PCR tube 5 is lower and can have more positions close to the magnetic field. The annular magnet 41 can be directly embedded in the mounting groove 101. In order to ensure the installation stability, it can also be fixed by bonding. The annular magnet 41 is located on its inner side. One of the inner wall or the outer wall is an N pole, and the other is an S pole, that is, a magnetic flux line similar to a horizontal direction is formed, so that a strong adsorption effect can be formed on the side wall located at the center hole 410. The pillar 2 is arranged on the base 1, and an installation cavity 20 is arranged in the pillar 2. The installation cavity 20 is provided with a lower magnet 42 and an upper magnet 43 that abut and adsorb each other. The support frame 3 is arranged on the upper part of the outer wall of the pillar 2, and a positioning hole 30 corresponding to the annular magnet 41 is provided on the support frame 3 for positioning the upper part of the PCR tube 5, that is, there are four positioning holes 30. The positioning holes 30 and the center hole 410 of the annular magnet 41 are arranged relative to each other to ensure that the PCR tube 5 is placed vertically.

[0028] In the utility model, based on the conventional method of adsorbing the magnetic microspheres in the PCR tube 5 to the inner wall of the PCR tube 5 through the magnetic attraction of the lower magnet 42 and the upper magnet 43 located in the pillar 2, the annular magnet 41 that can be sleeved on the bottom of the PCR tube 5 is further used to adsorb the magnetic microspheres and retain them at the bottom of the PCR tube 5. On the one hand, the adsorption effect of the entire magnetic separation device on the magnetic microspheres can be increased, and it can be ensured that all the microspheres can be adsorbed and fixed even if there are more magnetic microspheres. On the other hand, it can avoid excessive accumulation of microspheres on the inner wall of the PCR tube 5 when only the lower magnet 42 and the upper magnet 43 are present, and avoid the occurrence of microspheres occupying more space laterally after accumulation and affecting other subsequent operations.

[0029] The utility model can realize adsorption and fixation of the microspheres at the bottom of the PCR tube 5 by means of the annular magnet 41 additionally arranged on the base 1, thereby enhancing the adsorption effect and ensuring that the magnetic microspheres are adsorbed as evenly as possible.

[0030] Combination Figure 4 As shown, the pillar 2 includes a column 21 and a bottom plate 22, the installation cavity 20 is formed on the column 21, the diameter of the bottom plate 22 is larger than the diameter of the column 21, and the support stability of the column 21 can be ensured, the column 21 abuts against the bottom plate 22 and seals the installation cavity 20 and the lower magnet 42 and the upper magnet 43 therein; the base 1 is provided with a through hole 102, the column 21 passes through the through hole 102, and the bottom plate 22 abuts against the lower end of the base 1. The installation method of the pillar 2 and the base 1 can be specifically as follows: the upper magnet 43 and the lower magnet 42 are sequentially loaded into the installation cavity 20, the lower end of the column 21 is passed downward through the through hole 102 and then abutted against the bottom plate 22, and the bottom plate 22 is abutted against the base 1 to complete the installation. This design form can conveniently remove the base 1 and only retain the pillar 2 and the support frame 3 for the case where there are fewer magnetic microspheres contained in the PCR tube 5, that is, it is convenient to install and disassemble the base 1.

[0031] Furthermore, the upper magnet 43 is arranged at the upper part of the mounting cavity 20, and the lower magnet 42 is fixed on the bottom plate 22, and extends into the mounting cavity 20 to abut against the upper magnet 43. For example, the upper magnet 43 can be fixed in the mounting cavity 20 by bonding, and then the bottom plate 22 can be fixed to the column 21 after the lower magnet 42 extends into the mounting cavity 20 to abut and adsorb against the upper magnet 43, so that the installation of the pillar 2 is more convenient. In addition, a fixing groove 220 can be provided on the bottom plate 22, and the lower part of the lower magnet 42 is fixedly arranged in the fixing groove 220.

[0032] A limiting groove 103 is provided at the lower end of the base 1 next to the through hole 102, and the bottom plate 22 is embedded in the limiting groove 103, so that the base 1 can contact the placement surface with a larger area than the bottom plate 22, and avoid the unevenness of the bottom, thereby ensuring the stability of the placement of the entire magnetic separation device.

[0033] The bottom plate 22 is a circular structure, which does not intersect with the vertical projection of the positioning hole 30 .

[0034] like Figure 5 As shown, at least one positioning plate 211 is provided at the lower part of the side wall of the column 21, and an embedding groove 104 connected to the through hole 102 is provided on the base 1. The positioning plate 211 is embedded in the embedding groove 104, which can prevent the column 21 from rotating relative to the base 1, and can also ensure that the center hole 410 on the annular magnet 41 can be relative to the positioning hole 30 through the cooperation between the positioning plate 211 and the embedding groove 104.

[0035] In addition, a limiting plate (not shown) may be provided at the upper end of the positioning plate 211 , the limiting plate abutting against the upper end of the base 1 , and the base 1 is positioned on the pillar 2 through the combined action of the limiting plate and the bottom plate 22 .

[0036] The height of the lower magnet 42 is smaller than that of the upper magnet 43, so that the magnetic lines of force are more concentrated in the middle and lower parts, and can play a better role.

[0037] The specific embodiments described herein are merely examples of the spirit of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in similar ways, but they will not deviate from the spirit of the present invention or exceed the scope defined by the appended claims.

Claims

1. An adsorption-enhanced magnetic separation device, characterized in that: include: The base is provided with at least one mounting groove, wherein a ring magnet is provided in the mounting groove for extending into the bottom of the PCR tube, wherein one of the inner wall or the outer wall of the ring magnet is an N pole, and the other is an S pole, A support column is arranged on the base, wherein a mounting cavity is arranged in the support column, wherein a lower magnet and an upper magnet which abut against and adsorb each other are arranged in the mounting cavity, A support frame is arranged on the pillar, and a positioning hole corresponding to the annular magnet and used for positioning the upper part of the PCR tube is provided on the support frame.

2. The adsorption-enhanced magnetic separation device according to claim 1, characterized in that: The pillar includes a column and a base plate, the installation cavity is formed on the column, the diameter of the base plate is larger than the diameter of the column, the two are in contact with each other and seal the installation cavity; a through hole is provided on the base, the column passes through the through hole, and the base plate is in contact with the lower end of the base.

3. The adsorption-enhanced magnetic separation device according to claim 2, characterized in that: The upper magnet is arranged at the upper part of the installation cavity, and the lower magnet is fixed on the bottom plate and extends into the installation cavity to abut against the upper magnet.

4. The adsorption-enhanced magnetic separation device according to claim 3, characterized in that: The bottom plate is provided with a fixing groove, and the lower part of the lower magnet is arranged in the fixing groove.

5. The adsorption-enhanced magnetic separation device according to any one of claims 2 to 4, characterized in that: A limiting groove is provided at the lower end of the base beside the through hole, and the bottom plate is embedded in the limiting groove.

6. The adsorption-enhanced magnetic separation device according to claim 5, characterized in that: The bottom plate is a circular structure and does not intersect with the vertical projection of the positioning hole.

7. The adsorption-enhanced magnetic separation device according to claim 2, characterized in that: At least one positioning plate is provided at the lower part of the side wall of the column, and an embedding groove communicating with the through hole is provided on the base, and the positioning plate is embedded in the embedding groove.

8. The adsorption-enhanced magnetic separation device according to claim 7, characterized in that: A limiting plate is provided at the upper end of the positioning plate, and the limiting plate abuts against the upper end of the base.

9. The adsorption-enhanced magnetic separation device according to claim 1, characterized in that: The height of the lower magnet is smaller than the height of the upper magnet.

10. The adsorption-enhanced magnetic separation device according to claim 1, characterized in that: The number of the positioning holes is four, and the four positioning holes are symmetrically arranged.

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