Liquid sample sampling chip and liquid sample analysis device

Abstract

The utility model discloses a liquid sample sampling chip and a liquid sample analysis device, and the liquid sample sampling chip comprises a core body which rotates around a centrifugal center; the sampling area is positioned at the proximal end of the core body, is used for enriching and temporarily storing a liquid sample and comprises a sampling area recess formed in the core body and an adsorption column positioned in the sampling area recess, and the sampling area recess and the adsorption column are both of a parent sample structure; the liquid collecting area is located at the telecentric end of the core body, the proximal end is communicated with the telecentric end of the sampling area, and the liquid collecting area is used for quantitatively distributing the liquid sample; the cover plate is connected with the core body and forms closed spaces with the sampling area and the liquid collecting area respectively. By arranging the sampling area recess and the adsorption column of the sampling area as a parent sample structure, enrichment and temporary storage of a liquid sample can be realized, the structure is simple, the cost is low, the liquid sample is not easy to damage, and the portability and the use efficiency of an instrument are facilitated.

Description

Technical Field

[0001] The utility model relates to the technical field of microfluidics, in particular to a liquid sample sampling chip and a liquid sample analysis device. Background Art

[0002] In the fully automatic analysis of liquid samples, the first step is to enrich and temporarily store the samples in a fixed area. At present, the commonly used solution is to control the sampling needle through a plunger pump to draw a quantitative amount of liquid from a large number of samples and transfer it to the reaction device. This method is reliable enough in terms of pipetting accuracy and positioning accuracy, but the required instrument has a complex structure, large size, high price, and is easy to damage, which is not conducive to the portability and efficiency of the instrument.

[0003] Therefore, how to provide a liquid sampling chip to achieve the enrichment and temporary storage of the sampled liquid is a technical problem that needs to be solved urgently by those skilled in the art. Utility Model Content

[0004] In view of this, the utility model provides a liquid sampling chip to achieve the enrichment and temporary storage of the sampled liquid. In addition, the utility model also provides a liquid sample analysis device having the liquid sampling chip.

[0005] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0006] A liquid sample sampling chip, comprising:

[0007] A core body, the core body rotating around a centrifugal center;

[0008] A sampling area, the sampling area is located at the proximal end of the core body, and is used to enrich and temporarily store liquid samples. The sampling area includes a sampling area depression arranged on the core body and an adsorption column located in the sampling area depression. Both the sampling area depression and the adsorption column are sample-friendly structures;

[0009] A liquid collection area, wherein the liquid collection area is located at the distal end of the core body, and the proximal end of the liquid collection area is connected to the distal end of the sampling area;

[0010] A cover plate, the cover plate is connected to the core body, and forms a liquid storage space with the sampling area and the liquid collection area. Preferably, in the above-mentioned liquid sample sampling chip, the sampling area also includes:

[0011] A ventilation structure is located at the distal end of the sampling area, the ventilation structure is connected to the sampling area depression and the liquid collection area, and the side of the ventilation structure in contact with the sampling area depression is a sample-free structure.

[0012] Preferably, in the above-mentioned liquid sample sampling chip, the sampling area depression is a fan-shaped plate, and the ventilation structure is an arc-shaped channel arranged around the edge of the distal end of the sampling area depression;

[0013] or,

[0014] The sampling area depression is a rectangular plate, and the ventilation structure is a channel located at the edge vertex corner of the distal end of the sampling area depression.

[0015] Preferably, in the above-mentioned liquid sample sampling chip, the upper surface and the lower surface of the core body are both provided with the sampling area recess and the adsorption column.

[0016] The upper surface and the lower surface of the core are connected through a through hole.

[0017] Preferably, in the above-mentioned liquid sample sampling chip, the side surface between the sampling area depression on the upper surface and the sampling area depression on the lower surface of the core body has the adsorption column.

[0018] Preferably, in the above-mentioned liquid sample sampling chip, there are a plurality of connected accommodating spaces between the sampling area recess on the upper surface of the core body and the sampling area recess on the lower surface, each of the accommodating spaces has the adsorption column, and the through hole is connected to the accommodating space.

[0019] Preferably, in the above-mentioned liquid sample sampling chip, the ventilation structure forms the through hole.

[0020] Preferably, in the above-mentioned liquid sample sampling chip, the side wall between the sampling area depression on the upper surface and the sampling area depression on the lower surface of the core body has a plurality of interconnected accommodating spaces, and the accommodating spaces are sample-friendly structures for enriching and temporarily storing the liquid sample.

[0021] Preferably, in the above-mentioned liquid sample sampling chip, the adsorption column is a conical cylinder fixed and recessed perpendicularly to the sampling area;

[0022] The adsorption columns are arranged in a matrix array, a ring array or a honeycomb shape.

[0023] A liquid sample analysis device comprises a liquid sample sampling chip, wherein the liquid sample sampling chip is any of the liquid sample sampling chips described above.

[0024] The utility model discloses a liquid sample sampling chip, wherein the sampling area depression and the adsorption column are both sample-friendly structures. When the sample liquid contacts the liquid inlet side of the chip, due to the sample-friendly properties of the sampling area depression and the adsorption column, the liquid sample automatically enters and gradually fills the area surrounded by the sampling area depression and the adsorption column, and the liquid is temporarily fixed in the sampling area depression of the sampling area. Due to the overall affinity of the sampling area to the target liquid, a slight movement will not cause the liquid to be thrown out of the chip, thereby realizing the enrichment and temporary storage of the liquid sample by the liquid sample sampling chip.

[0025] In the embodiment of the utility model, the sampling area depression and the adsorption column of the sampling area are set as a sample-friendly structure, so that the enrichment and temporary storage of the liquid sample can be achieved. The structure is simple, the cost is low, and it is not easy to damage, which is beneficial to the portability and use efficiency of the instrument. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0027] Figure 1 It is a front view of the liquid sampling chip disclosed in the embodiment of the utility model;

[0028] Figure 2 It is a schematic diagram of the disassembled structure of the liquid sampling chip disclosed in the embodiment of the utility model;

[0029] Figure 3 It is a partial structural schematic diagram of the liquid sampling chip disclosed in the embodiment of the utility model;

[0030] Figure 4 It is a front view of the sampling area disclosed in the embodiment of the utility model;

[0031] Figure 5 It is a schematic diagram of the structure of the sampling area disclosed in the embodiment of the utility model;

[0032] Figure 6 It is a schematic structural diagram of another direction of the sampling area disclosed in the embodiment of the utility model;

[0033] Figure 7 It is a structural schematic diagram of another direction of the sampling area disclosed in the embodiment of the utility model;

[0034] Figure 8 It is another structural schematic diagram of the sampling area disclosed in the embodiment of the utility model;

[0035] Fig. 9 It is a schematic diagram of the second structure of the core body in the sampling area disclosed in the embodiment of the utility model;

[0036] Fig.10 It is a schematic diagram of the third structure of the core body in the sampling area disclosed in the embodiment of the utility model;

[0037] Fig.11 It is a schematic diagram of the fourth structure of the core body in the sampling area disclosed in the embodiment of the utility model;

[0038] Fig.12 It is a schematic diagram of the fifth structure of the core in the sampling area disclosed in the embodiment of the utility model;

[0039] Fig.13 It is a structural schematic diagram when the ventilation structure disclosed in the embodiment of the utility model is a groove;

[0040] Fig.14 It is a front view of a first shape of the side wall of the core body disclosed in an embodiment of the utility model;

[0041] Fig.15 It is a front view of a second shape of the side wall of the core body disclosed in the embodiment of the utility model;

[0042] Fig.16 It is a front view of a third shape of the side wall of the core body disclosed in the embodiment of the utility model;

[0043] Fig.17 It is a front view of a fourth shape of the side wall of the core body disclosed in the embodiment of the utility model;

[0044] Fig.18 It is a front view of the fifth shape of the side wall of the core body disclosed in the embodiment of the utility model. DETAILED DESCRIPTION

[0045] The utility model discloses a liquid sampling chip, which realizes the enrichment and temporary storage of sampled liquid. In addition, the utility model also discloses a liquid sample analysis device having the liquid sampling chip.

[0046] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0047] In the following, the terms "first" and "second" are used for descriptive purposes only and are not to be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features.

[0048] like Figures 1 to 3 As shown, the embodiment of the utility model includes a liquid sample sampling chip, including a core body 1, a sampling area 3, a liquid collection area 2 and a cover plate 4.

[0049] The core 1 rotates around the centrifugal center o, and the centrifugal movement of the liquid sample is realized during the rotation. The sampling area 3 is located at the proximal end of the core 1, and the liquid collection area 2 is located at the distal end of the core 1, and the distal end of the sampling area 3 is connected to the proximal end of the liquid collection area 2. The sampling area 3 is used to enrich and temporarily store the liquid sample. The above-mentioned cover plate 4 covers the core 1 and forms a liquid storage space with the sampling area 3 and the liquid collection area 2 respectively.

[0050] Combination Figure 4 As shown, the sampling area 3 in the embodiment of the utility model includes a liquid inlet side 31 , a sampling area recess 32 and an adsorption column 33 .

[0051] The liquid inlet side 31 is the proximal end of the sampling area 3 . In some embodiments, the cover plate 4 forms an inlet for the liquid sample at the liquid inlet side 31 of the sampling area 3 .

[0052] The sampling area depression 32 is a depression on the core body 1, which is lower than the chip surface as a whole, and is connected to the outside atmosphere through the liquid inlet side 31 after being packaged with the cover plate 4; the adsorption column 33 is a protruding column in the sampling area depression 32, and its top is not higher than the chip surface around the sampling area 3.

[0053] In an optional embodiment, the distance between the sampling area recess 32 and the cover plate 4 is in the range of 0.2 mm-3 mm, preferably, 0.7 mm-1.5 mm.

[0054] In some embodiments, both the sampling area recess 32 and the adsorption column 33 are sample-friendly structures. When the sample liquid contacts the liquid inlet side 31 of the chip, due to the sample-friendly properties of the sampling area recess 32 and the adsorption column 33, the liquid sample will automatically enter and gradually fill the area surrounded by the sampling area recess 32 and the adsorption column 33. At this time, the liquid is temporarily fixed in the sampling area recess 32 of the sampling area 3. Due to the overall affinity of the sampling area 3 to the target liquid, a slight movement will not cause the liquid to be thrown out of the chip, thereby achieving the enrichment and temporary storage of the liquid sample by the liquid sample sampling chip.

[0055] In the embodiment of the utility model, by setting the sampling area recess 32 and the adsorption column 33 of the sampling area 3 as a sample-friendly structure, the enrichment and temporary storage of the liquid sample can be achieved. The structure is simple, the cost is low, and it is not easy to be damaged, which is beneficial to the portability and use efficiency of the instrument.

[0056] It should be noted that the cover plate 4 herein includes but is not limited to a sealing film.

[0057] It may also be a soft film or a hard cover plate. The cover plate 4 is fixed on the chip in ways including but not limited to gluing, welding, bonding, etc.

[0058] Combination Figures 4 to 7 As shown, the sampling area 3 also includes a ventilation structure 34 .

[0059] Specifically, the ventilation structure 34 is located at the distal end of the sampling area 3, and the ventilation structure 34 is connected to the sampling area recess 32 and the liquid collecting area 2. The sampling area 3 is connected to the atmosphere on the side away from the liquid inlet side 31 through the ventilation structure 34 and the liquid collecting area 2 that are repellent to the liquid sample, thereby ensuring that the sampling area 3 will not be unable to be filled due to air embolism during the process of the liquid sample filling the sampling area 3.

[0060] In some embodiments, the shape of the ventilation structure 34 is not limited. The ventilation structure 34 is adjacent to the distal end of the sampling area 3, and the height difference between the two ranges from 0.3 mm to 5 mm, preferably from 1 mm to 5 mm.

[0061] In the present application, the side of the ventilation structure 34 in contact with the sampling area recess 32 is a sample-free structure. After the liquid sample enters and gradually fills the area surrounded by the sampling area recess 32 and the adsorption column 33, it stops when it contacts the edge of the ventilation structure 34, so that the liquid sample is temporarily fixed between the sampling area 3 and the ventilation structure 34. Since the side of the ventilation structure 34 in contact with the sampling area recess 32 is a sample-free structure, the liquid sample can be fixed at the set position and other positions can be kept clean.

[0062] After the liquid sample sampling chip starts centrifugation, the liquid sample in the sampling area 3 will flow to a place with lower centrifugal potential energy, that is, through the ventilation structure 34, and finally flow to the liquid collection area 2. Since the centrifugal potential energy of the sampling area 3 and the ventilation structure 34 is higher than that of the liquid collection area 2, after the centrifugal force and centrifugation time are sufficient, all the liquid samples will be driven by the centrifugal force to flow into the liquid collection area 2 without any residue.

[0063] In summary, due to the affinity between the sampling area recess 32, the adsorption column 33 and the ventilation structure 34 for the liquid sample, when the target liquid sample contacts the liquid inlet side 31, the liquid sample will automatically flow into the sample affinity area in the sampling area 3 and will not flow to other locations.

[0064] In addition, in order to prevent the liquid sample from forming bubble embolism during the process of filling the sampling area 3, which makes it impossible to fill the entire area, the ventilation structure 34 has a stronger property of repelling the target liquid, thereby ensuring that the target liquid sample only fills the gap area surrounded by the sampling area depression 32 and the adsorption column 33, and will not enter the ventilation structure 34 in advance during the filling process. The original air in the sampling area 3 passes through the ventilation structure 34 and is finally discharged from the pipe leading to the atmosphere from the liquid collection area 2. At the same time, due to the height difference between the ventilation structure 34 and the bottom of the sampling area depression 32, the affinity / repellency treatment process and effect of the sample liquid are more friendly, and a clear boundary can be formed during the liquid flow process.

[0065] Figures 4 to 7 The sampling area groove 32 in the illustrated embodiment is a sector-shaped plate, and the corresponding ventilation structure 34 is an arc-shaped channel arranged around the edge of the distal end of the sampling area recess 32 .

[0066] When the sampling area depression 32 has a large area, it is easy to cause the problem that part of the air is blocked in the sampling area 3 and difficult to be discharged due to the inconsistent filling speed of the liquid during the process of the liquid sample entering the sampling area 3, forming bubbles, thereby affecting the quantitative accuracy. Therefore, Figures 4 to 7 The ventilation structure 34 in the illustrated embodiment is an arc-shaped channel with a relatively large area, so that the air in the sampling area recess 32 can quickly enter the ventilation structure 34, ensuring that the liquid sample can fill the sampling area 3 as quickly as possible.

[0067] like Figure 8 The sampling area recess 32 in the illustrated embodiment is a rectangular plate, and the corresponding ventilation structure 34 is a channel located at the edge corner of the distal end of the sampling area recess 32 .

[0068] because Figure 8 The total area of ​​the sampling area recess 32 is not large, and it is not easy to cause the problem of part of the air being blocked in the sampling area 3 and difficult to be discharged due to the inconsistent filling speed of the liquid during the liquid filling process, so the ventilation structure 34 does not need to form a shape that approximately surrounds the edge of the sampling area recess 32. Specifically, the size of the ventilation structure 34 can be set accordingly according to the amount of the inhaled liquid sample and the shape of the sampling area recess 32.

[0069] like Figures 4 to 6 as well as Figure 8 As shown, the sampling area 3 further includes a liquid collecting pipe 35. The liquid collecting pipe 35 connects the distal end of the ventilation structure 34 with the proximal end of the liquid collecting area 2.

[0070] The cross-sectional shape of the collecting tube 35 can be semicircular, rectangular, rounded rectangular, trapezoidal, rounded trapezoidal, triangular, etc., or a combination of the above shapes; the width and depth of the collecting tube 35 are both in the range of 0.1mm-1mm; preferably, 0.2mm-0.7mm.

[0071] Combination Fig. 9 and Fig.10 As shown, the upper and lower surfaces of the core body 1 are both provided with sampling area recesses 32 and adsorption columns 33, and the upper and lower surfaces of the core body 1 respectively form a containing space for liquid sample enrichment and temporary storage through the cover plate 4, and the upper and lower surfaces of the core body 1 are connected through a through hole.

[0072] It should be noted that the upper and lower surfaces of the core body 1 are connected with a cover plate 4, and adsorption columns 33 are arranged on the upper and lower surfaces of the core body 1, so that sampling areas 3 are formed on the upper and lower surfaces of the core body 1 to increase the sampling volume.

[0073] In order to ensure that both the upper and lower surfaces of the core 1 can absorb the liquid sample, the upper and lower surfaces of the core 1 need to be made into the shape of the sampling area and both are sample-friendly. In some embodiments, a through hole is opened on the core 1.

[0074] The through hole connects the upper surface and the lower surface. Under the action of centrifugal force, all samples fixed in the sampling area will flow down and gather toward the structure at the distal end, so that the samples on the upper surface and the lower surface of the core body 1 can flow into the liquid collection area 2.

[0075] Fig.10 The adsorption columns 33 on both sides of the core body 1 are brought close together so that the wall in the middle of the core body 1 is thin enough to reduce the time for the liquid sample to flow to the other side of the core body 1, thereby ensuring that the upper and lower surfaces can absorb the liquid sample at the same time during the sampling process.

[0076] certainly, Fig.10 The adsorption columns 33 on both sides can also increase the liquid absorption speed and liquid absorption amount.

[0077] like Fig.11 In the illustrated embodiment, a plurality of interconnected accommodating spaces are provided between the sampling area recess on the upper surface and the sampling area recess on the lower surface of the core 1, and each accommodating space has an adsorption column 33, and the through hole is connected to the accommodating space.

[0078] In the present application, multiple sampling areas 3 exist at different thickness positions at the same time, forming a multi-layer sampling area 3 structure, thereby increasing the volume of liquid samples that can be temporarily stored per unit area of ​​the liquid sample sampling chip, and improving the amount and efficiency of the liquid sample fixed by the liquid sample sampling chip. In addition, the sampling area 3 inside the liquid sample sampling chip does not need to be covered by the cover plate 4, and its own multi-layer structure is sufficient to partially cover the top of the adsorption column 33 in the sampling area 3, thereby replacing the role of the cover plate 4 and reducing costs and process difficulties.

[0079] Fig.11The core 1 with multiple layers of sampling areas can achieve a larger amount of liquid sample fixation, but its complex shape limits its processing technology. Therefore, in some embodiments, 3D printing, layered processing and chemical bonding assembly can be used to achieve this. However, the above processing method has high processing costs and cannot achieve large-scale mass production.

[0080] In a further embodiment, the present utility model also discloses a structure of a core 1, such as Fig.12 shown.

[0081] Fig.12 The core body 1 is provided with a sampling area recess 32 and an adsorption column 33 on both the upper and lower surfaces. Furthermore, an adsorption column 33 is also provided on the side between the sampling area recess on the upper surface and the sampling area recess on the lower surface of the core body 1.

[0082] It should be noted that the shape and size of the adsorption column 33 on the side can be different from the shape and size of the adsorption column in the sampling area recess 32, so as to facilitate the use of CNC technology or injection molding to batch process the core 1. In the process of injection molding, in order to minimize injection defects, it is necessary to make the wall thickness of the core 1 as close as possible. Therefore, it is necessary to add a structure on the side of the core 1 to reduce the wall thickness to a level similar to that of other parts, thereby reducing the possibility of injection defects. Fig. 9 The plastic layer between the sampling areas is too thick. Fig.12 The middle structure is more convenient for injection molding.

[0083] When the added structure meets the principle of "facilitating injection molding and imitating the adsorption column as much as possible", the side of the core 1 also has some sample fixing effect, thereby increasing the total amount of samples that can be fixed by the chip while keeping the core area unchanged. The side structure of the core 1 is the "accommodation space" that can accommodate part of the liquid sample, and its shape is not clearly limited, for example Figure 12-18 It will be all right.

[0084] The space for storing samples in the sampling area in this article is all containing space.

[0085] In some embodiments, sample-friendly processing is performed on the side adsorption column 33 and the surrounding shrinkage area to achieve enrichment and temporary storage of the liquid sample.

[0086] In some embodiments, Fig.13 As shown, if the adsorption column 33 is only provided on one side of the sampling area 3, that is, it is a single-layer accommodation space, the ventilation structure 34 can be a groove with a depth greater than the sampling area depression 32. If the sampling area is a multi-layer accommodation space, the ventilation structure 34 can be a through hole, or contain a plurality of support structures connected to the outer core body 1, so as to ensure that all samples after centrifugation are collected into the ventilation structure 34 and enter the liquid collecting tube 35.

[0087] like Figures 14 to 18 As shown, the side wall between the sampling area depression on the upper surface and the sampling area depression on the lower surface of the core 1 has a plurality of connected accommodating spaces, which are sample-friendly structures for enriching and temporarily storing liquid samples. The accommodating space is a channel structure connected to both the upper surface and the lower surface, and is used to temporarily fix the liquid sample. The shape and size of the accommodating space are not limited here.

[0088] Fig.14 and Fig.17 The central storage space is a horizontal and vertical cross channel. Fig.15 and Fig.18 It is a channel that bends horizontally and vertically in sequence, wherein the horizontal and vertical channels can be straight channels or curved channels. Fig.16 It is a special-shaped channel.

[0089] The adsorption column involved in the embodiment of the utility model includes but is not limited to a cone fixed perpendicular to the sampling area recess 32; the adsorption column 33 includes but is not limited to a matrix array, a ring array or a honeycomb arrangement. The height of the adsorption column 33 is not higher than the depth of the sampling area recess 32, and the height of the adsorption column 33 ranges from 0.3mm to 2.5mm, preferably from 0.5mm to 1.2mm.

[0090] The depth of the sampling zone, the height of the adsorption column, and the cross-sectional area of ​​the adsorption column on the side of the core body 1 are respectively greater than the depth of the sampling zone, the height of the adsorption column, and the cross-sectional area of ​​the adsorption column on the upper and lower surfaces of the core body 1, so as to facilitate injection molding of the core body 1.

[0091] The total volume of the liquid collection area 2 in this article is larger than the total volume enclosed by the sampling area recess 32 and the adsorption column 33, ensuring that all collected liquid samples can flow into the liquid collection area 2 after centrifugation and will not remain in the ventilation structure 34 or the liquid collection tube 35.

[0092] The material of the core 1 includes but is not limited to hard plastic, glass or metal. The processing method of the affinity or phobia sample can be spraying, coating or film coating.

[0093] The liquid sample sampling chip in the utility model can be applied to many fields such as biological detection, water pollutant monitoring or pesticide residue detection, such as realizing the sampling and detection of body fluids such as whole blood, serum, plasma, urine, sweat, saliva, semen, amniotic fluid or water samples, milk, juice, pollutants containing heavy metal ions, organic pollutants, inorganic pollutants, pesticide residues, etc.

[0094] The distal end involved in this article is the end away from the centrifugal center of the core 1, and the proximal end is the end close to the centrifugal center of the core 1. The centrifugal center is Figure 1 The position of o in the middle.

[0095] In addition, an embodiment of the utility model also discloses a liquid sample analysis device, including a liquid sample sampling chip, wherein the liquid sample sampling chip is the liquid sample sampling chip disclosed in the above embodiment. Therefore, the liquid sample analysis device having the liquid sample sampling chip also has all the above technical effects, which will not be repeated here one by one.

[0096] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0097] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A liquid sample sampling chip, characterized in that: include: A core body, the core body rotating around a centrifugal center; A sampling area, the sampling area is located at the proximal end of the core body, and is used to enrich and temporarily store liquid samples. The sampling area includes a sampling area depression arranged on the core body and an adsorption column located in the sampling area depression. Both the sampling area depression and the adsorption column are sample-friendly structures; A liquid collection area, wherein the liquid collection area is located at the distal end of the core body, and the proximal end of the liquid collection area is connected to the distal end of the sampling area; A cover plate is connected to the core body and forms liquid storage spaces with the sampling area and the liquid collecting area respectively.

2. The liquid sample sampling chip according to claim 1, characterized in that: The sampling area also includes: A ventilation structure is located at the distal end of the sampling area, the ventilation structure is connected to the sampling area depression and the liquid collection area, and the side of the ventilation structure in contact with the sampling area depression is a sample-free structure.

3. The liquid sample sampling chip according to claim 2, characterized in that: The sampling area depression is a fan-shaped plate, and the ventilation structure is an arc-shaped channel arranged around the edge of the distal end of the sampling area depression; or, The sampling area depression is a rectangular plate, and the ventilation structure is a channel located at the edge vertex corner of the distal end of the sampling area depression.

4. The liquid sample sampling chip according to claim 2, characterized in that: The upper surface and the lower surface of the core are both provided with the sampling area recess and the adsorption column. The upper surface and the lower surface of the core are connected through a through hole.

5. The liquid sample sampling chip according to claim 4, characterized in that: The side surface between the sampling area recess on the upper surface of the core and the sampling area recess on the lower surface of the core is provided with the adsorption column.

6. The liquid sample sampling chip according to claim 4, characterized in that: A plurality of communicating accommodating spaces are provided between the sampling area recess on the upper surface of the core body and the sampling area recess on the lower surface. The adsorption columns are provided in the accommodating spaces, and the through holes are communicated with the accommodating spaces.

7. The liquid sample sampling chip according to claim 4, characterized in that: The ventilation structure forms the through hole.

8. The liquid sample sampling chip according to claim 4, characterized in that: The side wall between the sampling area depression on the upper surface of the core and the sampling area depression on the lower surface has a plurality of interconnected accommodating spaces, and the accommodating spaces are sample-friendly structures for enriching and temporarily storing the liquid sample.

9. The liquid sample sampling chip according to any one of claims 1 to 8, characterized in that: The adsorption column is a conical cylinder fixed vertically to the sampling area; The adsorption columns are arranged in a matrix array, a ring array or a honeycomb shape.

10. A liquid sample analysis device, comprising a liquid sample sampling chip, characterized in that: The liquid sample sampling chip is the liquid sample sampling chip as claimed in any one of claims 1 to 9.

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