Body fluid collection container assembly

Abstract

The utility model relates to a body fluid collecting container assembly which comprises a body fluid collecting container structure. The outer wall of the body fluid collection container cover structure is in sealing fit with the opening of the body fluid container structure; the body fluid storage container structure can be matched with the inner wall of the body fluid collection container cover structure. According to the technical scheme, the problem that errors are easily formed during body fluid sampling and collecting in the prior art is effectively solved.

Description

Technical Field

[0001] The present application relates to the technical field of body fluid collection containers, and in particular, to a body fluid collection container assembly. Background Art

[0002] cfDNA (cell-free DNA) refers to degraded cell-free DNA molecules released by cells and free in body fluids (blood, urine, saliva, cerebrospinal fluid, etc.). The content in the blood of healthy people is extremely low, but with the development of diseases such as tumors and inflammation, the content of cfDNA in the body will gradually increase. cfDNA includes circulating tumor DNA, mitochondrial DNA and fetal DNA, and has important applications in non-invasive / minimally invasive liquid biopsy, especially in the field of early cancer screening.

[0003] Traditional cfDNA research uses plasma samples, while urine cfDNA has been less studied and applied. Although urine collection has advantages over blood, such as convenient sampling and large urine sample volume, it is limited by the following points: urine has complex components and many impurities, especially higher DNA enzyme activity, which is more likely to cause the degradation of urine cfDNA; urine contains shed cells, and the somatic cell DNA released by them will affect the analysis of cfDNA; urine contains microorganisms, which may cause urine samples to deteriorate. Therefore, it is urgent to solve these problems to facilitate the promotion of clinical application of urine cfDNA.

[0004] When conducting a physical examination, body fluid testing can be used, and the body fluid is placed in a container for reaction, separation, and other operations.

[0005] In some prior art, body fluids and reagents are placed in containers for reaction. When collecting body fluids, they are either collected and used directly or poured directly into containers after collection. Such a collection method results in large sample collection errors. Utility Model Content

[0006] The present application provides a body fluid collection container assembly to solve the problem in the prior art that errors are easily formed in body fluid sampling and collection.

[0007] A body fluid collection container assembly provided according to the present application includes: a body fluid collection container structure; a body fluid collection container cover structure, the outer wall of the body fluid collection container cover structure is sealed with the opening of the body fluid collection container structure; and a body fluid storage container structure, which can be matched with the inner wall of the body fluid collection container cover structure.

[0008] Furthermore, the body fluid collection container cover structure includes a body fluid collection container fitting, an isolation part, a straw and a cover body. The outer wall of the body fluid collection container fitting is matched with the container mouth of the body fluid collection container structure. The isolation part is arranged inside the body fluid collection container fitting, the straw is arranged inside the body fluid collection container fitting, and the two ends of the straw are respectively located on both sides of the isolation part, and the cover body is covered on the outer end of the body fluid collection container fitting.

[0009] Furthermore, the body fluid collection container matching body is a matching tube, the edge of the isolation part is sealed with the inner wall of the matching tube, the suction straw is located in the matching tube and seals through the isolation part.

[0010] Furthermore, the matching tube includes a cylindrical section and a frustum section, the first end of the cylindrical section is connected to the small end of the frustum section, the large end of the frustum section is located outside the body fluid collection container structure, and the isolation part is arranged at the connection between the cylindrical section and the frustum section.

[0011] Furthermore, the body fluid collection container cover structure also includes a filter, which is arranged at the second end of the cylindrical section, and the inner end of the straw is connected to the filter.

[0012] Furthermore, the filter comprises a shell and a filter element arranged in the shell, and the inner end of the straw matches with the shell and is communicated with the inside of the shell.

[0013] Furthermore, the body fluid collection container structure includes a body fluid container and a body fluid collection cup, the body fluid container has a container opening, the body fluid collection cup includes a liquid inlet and a liquid outlet, the liquid outlet is sealed and connected to the body fluid container, and the liquid inlet is larger than the liquid outlet.

[0014] Furthermore, the body fluid collection cup includes a cup body, which includes a first arc segment and a second arc segment connected in sequence, the curvature radius of the first arc segment is greater than the curvature radius of the second arc segment, the liquid inlet is formed on a side of the first arc segment away from the second arc segment, and the liquid outlet is formed on a side of the second arc segment away from the first arc segment.

[0015] Furthermore, the body fluid collection cup also includes a valve and a branch pipe, the branch pipe is arranged between the cup body and the liquid outlet, and the valve is arranged between the branch pipe and the liquid outlet.

[0016] Furthermore, the body fluid storage container structure includes a test tube and a soft plug, and the soft plug is sealingly arranged at the opening of the test tube.

[0017] By applying the technical solution of the present application, after the body fluid collection container structure has collected the body fluid, the body fluid in the body fluid collection container structure is transferred to the body fluid storage container structure through the body fluid collection thermal container cover structure, so that the collection, transfer and storage of body fluids are relatively accurate. The technical solution of the present application effectively solves the problem that errors are easily formed in body fluid sampling and collection in the prior art. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present application and, together with the description, serve to explain the principles of the present application.

[0019] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0020] Figure 1 A schematic diagram showing a body fluid collection container structure of a body fluid collection container assembly according to an embodiment of the present application;

[0021] Figure 2 Shows Figure 1 A schematic structural diagram of a body fluid collection container cover structure of a body fluid collection container assembly;

[0022] Figure 3 Shows Figure 1 A schematic diagram of the structure of a body fluid storage container of a body fluid collection container assembly;

[0023] Figure 4 Shows Figure 1 Schematic diagram of the structure of the filter of the liquid collection container assembly.

[0024] The above drawings include the following reference numerals:

[0025] 10. Body fluid collection container structure; 11. Body fluid container; 12. Body fluid collection cup; 121. Cup body; 122. Valve; 123. Branch pipe; 20. Body fluid collection container cover structure; 21. Body fluid collection container matching body; 22. Straw; 23. Cover body; 24. Filter; 30. Body fluid storage container structure; 31. Test tube; 32. Soft stopper. DETAILED DESCRIPTION

[0026] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0027] It should be noted that the following detailed descriptions are illustrative and are intended to provide further explanation of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present application belongs.

[0028] For ease of description, spatially relative terms such as "above", "above", "on the upper surface of", "above", etc. may be used herein to describe the spatial positional relationship between a device or feature and other devices or features as shown in the figure. It should be understood that spatially relative terms are intended to include different orientations of the device in use or operation in addition to the orientation described in the figure. For example, if the device in the accompanying drawings is inverted, the device described as "above other devices or structures" or "above other devices or structures" will be positioned as "below other devices or structures" or "below other devices or structures". Thus, the exemplary term "above" may include both "above" and "below". The device may also be positioned in other different ways, rotated 90 degrees or in other orientations, and the spatially relative descriptions used herein are interpreted accordingly.

[0029] like Figures 1 to 3 As shown, the body fluid collection container assembly of this embodiment includes: a body fluid collection container structure 10, a body fluid collection container cover structure 20 and a body fluid storage container structure 30. The outer wall of the body fluid collection container cover structure 20 is sealed with the opening of the body fluid collection container structure 10. The body fluid storage container structure 30 can be matched with the inner wall of the body fluid collection container cover structure 20.

[0030] By applying the technical solution of this embodiment, after the body fluid collection container structure 10 collects body fluid, the body fluid in the body fluid collection container structure 10 is transferred to the body fluid storage container structure 30 through the body fluid collection container cover structure 20. Such collection, transfer and storage make the body fluid collection, transfer and storage more accurate and less likely to be contaminated. The technical solution of this embodiment effectively solves the problem of errors in body fluid sampling and collection in the prior art.

[0031] like Figure 2As shown, in the technical solution of this embodiment, the body fluid collection container cover structure 20 includes a body fluid collection container matching body 21, a separation part, a straw 22 and a cover 23. The outer wall of the body fluid collection container matching body 21 matches with the container mouth of the body fluid collection container structure 10. The separation part is arranged inside the body fluid collection container matching body 21. The straw 22 is arranged inside the body fluid collection container matching body 21. The two ends of the straw 22 are respectively located on both sides of the separation part. The cover 23 covers the outer end of the body fluid collection container matching body 21. When in use, the body fluid storage container structure 30 is inserted into the straw 22, and the straw 22 sucks the body fluid in the body fluid collection container structure 10 into the body fluid storage container structure 30, thereby avoiding the body fluid from contacting with the outside, such as contact with the outside air. It should be noted that the above-mentioned outer end refers to the end located outside the body fluid collection container structure 10 after the body fluid collection container cooperation body 21 is matched with the body fluid collection container structure 10; the inner end refers to the end located inside the body fluid collection container structure 10 after the body fluid collection container cooperation body 21 is matched with the body fluid collection container structure 10.

[0032] like Figure 2 As shown, in the technical solution of this embodiment, the body fluid collection container matching body 21 is a matching tube, the edge of the isolation part is sealed with the inner wall of the matching tube, and the suction tube 22 is located in the matching tube and passes through the isolation part in a sealed manner. The above structure is compact and easy to use. When in use, the matching tube is sealed and connected to the body fluid container 11 through a thread, and the outer end of the suction tube 22 is inserted into the soft plug 32, and the body fluid in the body fluid container 11 is sucked into the test tube 31 through negative pressure. The above structure has high operating efficiency.

[0033] like Figure 2 As shown, in the technical solution of this embodiment, the matching tube includes a cylindrical section and a frustum section, the first end of the cylindrical section is connected to the small end of the frustum section, the large end of the frustum section is located outside the body fluid collection container structure 10, and the isolation portion is arranged at the connection between the cylindrical section and the frustum section. The arrangement of the frustum section makes it easy to achieve sealing when the body fluid storage container structure 30 is matched with the frustum section, and the versatility is stronger. For example, a larger model of the soft plug 32 can match the frustum section shallowly, and a smaller model of the soft plug 32 can match the frustum section deeper. If a better seal is required, the matching can be deeper.

[0034] like Figure 2 and Figure 4 As shown, in the technical solution of this embodiment, the body fluid collection container cover structure 20 also includes a filter 24, which is arranged at the second end of the cylindrical section, and the inner end of the suction tube 22 is connected to the filter 24. The arrangement of the filter 24 makes the impurities of the body fluid sucked into the test tube 31 better and the purity higher, which further improves the accuracy of the body fluid test.

[0035] like Figure 4As shown, in the technical solution of this embodiment, the filter 24 includes a housing and a filter element disposed in the housing, and the inner end of the straw 22 matches the housing and communicates with the inside of the housing. The above structure is convenient to set up, and the filter element is not easily damaged or invalidated under the protection of the housing. The housing can be made of a material such as plastic that will not produce test errors.

[0036] like Figure 1 As shown, in the technical solution of this embodiment, the body fluid collection container structure 10 includes a body fluid container 11 and a body fluid collection cup 12, the body fluid container 11 has a container mouth, the body fluid collection cup 12 includes a liquid inlet and a liquid outlet, the liquid outlet is sealed and connected to the body fluid container 11, and the liquid inlet is larger than the liquid outlet. The setting of the body fluid collection cup 12 makes it easier to collect body fluids. The body fluid can be blood, urine, saliva, cerebrospinal fluid, etc. cfDNA (cell-free DNA) refers to degraded cell-free DNA molecules released by cells and free in body fluids (blood, urine, saliva, cerebrospinal fluid, etc.). The content in the blood of healthy people is extremely low, but with the development of diseases such as tumors and inflammation, the cfDNA content in the body will gradually increase. cfDNA includes circulating tumor DNA, mitochondrial DNA and fetal DNA, and has important applications in non-invasive / minimally invasive liquid biopsy, especially in the field of early cancer screening. Traditional cfDNA research uses plasma samples, while urine cfDNA research and application are less. Although urine collection has the advantages of convenient sampling and large urine sample volume compared to blood, it is limited by the following points: the composition of urine is complex and contains many impurities, especially the higher activity of DNA enzymes, which is more likely to cause the degradation of urine cfDNA; urine contains shed cells, and the somatic cell DNA released by them will affect the analysis of cfDNA; urine contains microorganisms, which may cause urine samples to deteriorate. In this embodiment, urine is taken as an example, and urine is first collected into the body fluid container 11 through the body fluid collection cup 12, which is easier, more convenient and more hygienic than collecting directly through the body fluid container 11.

[0037] like Figure 1 As shown, in the technical solution of this embodiment, the body fluid collection cup 12 includes a cup body 121, and the cup body 121 includes a first arc segment and a second arc segment connected in sequence, the curvature radius of the first arc segment is greater than the curvature radius of the second arc segment, the liquid inlet is formed on the side of the first arc segment away from the second arc segment, and the liquid outlet is formed on the side of the second arc segment away from the first arc segment. The above structure avoids splashing of urine and makes urine collection more convenient.

[0038] like Figure 1As shown, in the technical solution of this embodiment, the body fluid collection cup 12 also includes a valve 122 and a branch pipe 123. The branch pipe 123 is arranged between the cup body 121 and the liquid outlet, and the valve 122 is arranged between the branch pipe 123 and the liquid outlet. When collecting, the valve 122 is closed first, so that the urine at the beginning flows out from the branch pipe 123. When taking the middle urine, the valve 122 is opened, because it is easier for urine to flow into the body fluid container 11 than to flow out through the branch pipe 123. In this way, the urine will not enter the branch pipe, but will enter the body fluid container 11. It should be noted that the valve 122 should be close to the inlet of the branch pipe 123, so that the low-quality part of the urine can be discharged as much as possible. The lower part of the cup body 121 has a main pipe section, and it is relatively easy to set the valve 122 on the main pipe section, which will not be described in detail here.

[0039] like Figure 3 As shown, in the technical solution of this embodiment, the body fluid storage container structure 30 includes a test tube 31 and a soft plug 32, and the soft plug 32 is sealed at the opening of the test tube 31. The soft plug 32 has a certain deformation ability, and the puncture part of the straw 22 pierces the soft plug 32. After the body fluid is collected, the soft plug 32 can also restore the sealed state. It should be noted that the outer end of the straw 22 has a puncture part, and the puncture part is a puncture tip formed by the inclined surface of the straw 22. The soft plug can be a rubber plug, a silicone plug, a wooden plug, etc. The body fluid storage container structure 30 also includes a medicine, and the medicine is placed in the test tube, and the inside of the test tube is in a negative pressure state.

[0040] It should be noted that the above-mentioned body fluid storage container structure 30 and body fluid collection container cover structure 20 are sealed and packaged by sealing films before use. Taking urine collection as an example, the front urine is directly discharged through the urination tube, and then the switch of the valve 122 is turned, and the middle urine enters the urine cup (body fluid container 11). After collecting the middle urine, turn off the switch, and the remaining urine continues to be discharged through the urination tube (branch tube 123), and the entire urination process does not need to be interrupted. Then loosen the urine receiving device (body fluid collection container structure 10), cover the urine cup (body fluid container 11) with the urine cup cover (body fluid collection container cover structure 20), and gently shake the urine cup to mix the urine. Tear off the protective film on the urine cup cover, invert the urine collection tube and insert it into the groove of the urine cup cover, so that the needle pierces the urine collection tube plug cover (soft plug 32), and the middle urine enters the collection tube (test tube 31), gently invert to mix the urine and protective agent, and place it at room temperature.

[0041] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0042] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein, for example. In addition, the terms "including" and "having" and any of their variations are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units that are clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0043] The above are only preferred embodiments of the present application and are not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A body fluid collection container assembly, characterized in that: include: Body fluid collection container structure (10); A body fluid collection container cover structure (20), wherein the outer wall of the body fluid collection container cover structure (20) is in sealing cooperation with the opening of the body fluid collection container structure (10); A body fluid storage container structure (30), wherein the body fluid storage container structure (30) can be matched with the inner wall of the body fluid collection container cover structure (20).

2. The body fluid collection container assembly according to claim 1, characterized in that: The body fluid collection container cover structure (20) comprises a body fluid collection container fitting body (21), an isolation part, a straw (22) and a cover body (23); the outer wall of the body fluid collection container fitting body (21) matches with the container mouth of the body fluid collection container structure (10); the isolation part is arranged inside the body fluid collection container fitting body (21); the straw (22) is arranged inside the body fluid collection container fitting body (21); the two ends of the straw (22) are respectively located on both sides of the isolation part; and the cover body (23) is covered on the outer end of the body fluid collection container fitting body (21).

3. The body fluid collection container assembly according to claim 2, characterized in that: The body fluid collection container matching body (21) is a matching tube, the edge of the isolation part is sealed with the inner wall of the matching tube, and the suction tube (22) is located in the matching tube and seals through the isolation part.

4. The body fluid collection container assembly according to claim 3, characterized in that: The matching tube includes a cylindrical section and a frustum section, the first end of the cylindrical section is connected to the small end of the frustum section, the large end of the frustum section is located outside the body fluid collection container structure (10), and the isolation part is arranged at the connection between the cylindrical section and the frustum section.

5. The body fluid collection container assembly according to claim 4, characterized in that: The body fluid collection container cover structure (20) further comprises a filter (24), wherein the filter (24) is arranged at the second end of the cylindrical section, and the inner end of the straw (22) is connected to the filter (24).

6. The body fluid collection container assembly according to claim 5, characterized in that: The filter (24) comprises a shell and a filter element arranged in the shell, and the inner end of the suction tube (22) matches the shell and is communicated with the inside of the shell.

7. The body fluid collection container assembly according to claim 1, characterized in that: The body fluid collection container structure (10) comprises a body fluid container (11) and a body fluid collection cup (12), wherein the body fluid container (11) has a container opening, and the body fluid collection cup (12) comprises a liquid inlet and a liquid outlet, wherein the liquid outlet is sealedly connected to the body fluid container (11), and the liquid inlet is larger than the liquid outlet.

8. The body fluid collection container assembly according to claim 7, characterized in that: The body fluid collection cup (12) comprises a cup body (121), wherein the cup body (121) comprises a first arc segment and a second arc segment connected in sequence, wherein the radius of curvature of the first arc segment is greater than the radius of curvature of the second arc segment, wherein the liquid inlet is formed on a side of the first arc segment away from the second arc segment, and wherein the liquid outlet is formed on a side of the second arc segment away from the first arc segment.

9. The body fluid collection container assembly according to claim 8, characterized in that: The body fluid collection cup (12) further comprises a valve (122) and a branch pipe (123), wherein the branch pipe (123) is arranged between the cup body (121) and the liquid outlet, and the valve (122) is arranged between the branch pipe (123) and the liquid outlet.

10. The body fluid collection container assembly according to any one of claims 1 to 9, characterized in that: The body fluid storage container structure (30) comprises a test tube (31) and a soft plug (32), wherein the soft plug (32) is sealed and arranged at the opening of the test tube (31).

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