Centrifugal machine for preparing gadolinium contrast agent raw material medicine

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By designing the scratch assembly in the centrifuge prepared by gadolinium contrast agent raw material, impurities in the inner wall of the centrifuge barrel are automatically cleaned, which solves the problem of cleaning difficulties in the prior art, and improves the working efficiency of the centrifuge and the stability of the centrifuge effect.

CN222490477UActive Publication Date: 2025-02-18HEZE RUIZHI TECH DEV

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Patent Information

Application Number: CN202421210276.8
Authority / Receiving Office: CN · China
Patent Type: Utility models(China)
Current Assignee / Owner
Filing Date: 2024-05-30
Publication Date: 2025-02-18
Estimated Expiration: 2034-05-30

AI Technical Summary

Technical Problem

In the prior art, during the preparation of gadolinium contrast agent raw materials, impurities are easily adhered to the inner wall of the centrifuge barrel, which leads to difficulty in cleaning and affects the centrifugal effect.

Method used

A centrifuge for the preparation of gadolinium contrast agent raw materials was designed, equipped with scratching components, including scraper, movable plate, spring and fixed plate. The scraper contacts the inner wall of the centrifugal barrel through the drive motor and the transmission shaft, and automatically cleans it. Impurities.

Benefits of technology

By automatically cleaning the impurities in the inner wall of the centrifuge barrel, the centrifuge improves the working efficiency of the centrifuge, reduces the need for manual cleaning, and ensures the stability of the centrifuge effect.

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Abstract

The utility model discloses a centrifugal machine for preparing gadolinium contrast agent bulk drugs, which belongs to the technical field of gadolinium contrast agent bulk drug preparation and comprises a centrifugal machine body and a rubbing component. The centrifugal machine body comprises a machine body, a feeding pipe, a discharging block, a driving motor, a transmission shaft and a centrifugal barrel body. The feeding pipe is fixedly arranged on the machine body; the discharging block is fixedly arranged on the machine body; the driving motor is fixedly arranged on the machine body; one end of the transmission shaft is connected with the driving motor output end; the centrifugal barrel body is connected with the other end of the transmission shaft; the rubbing assembly is arranged in the machine body; the rubbing assembly comprises a fixed plate, a movable groove, a movable plate, a spring and a scraping plate; the fixed plate is arranged on the machine body; a movable groove is formed in one side of the fixed plate; the movable plate is arranged in the movable groove; two ends of the spring are respectively connected with the movable groove and the movable plate; the scraping plate is fixedly arranged on the movable plate; according to the centrifugal machine for preparing the gadolinium contrast agent raw material medicine, the inner wall of the centrifugal barrel body can be automatically cleaned in the centrifugal process, and the working efficiency of the centrifugal machine body is greatly improved.

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Description

Technical Field

[0001] The utility model belongs to the technical field of preparation of bulk drugs of gadolinium contrast agents, in particular to a centrifuge used for preparation of bulk drugs of gadolinium contrast agents. Background Art

[0002] Gadolinium contrast agents are intravenously injected drugs used in magnetic resonance imaging or magnetic resonance angiography to increase the contrast of images to make it easier to detect lesions or to show the extent of lesions more clearly.

[0003] In the process of preparing gadolinium contrast agent APIs, a centrifuge is often required to centrifuge the liquid and impurities in the gadolinium contrast agent APIs. The impurities in the gadolinium contrast agent APIs will adhere to the inner wall of the centrifuge bucket of the centrifuge. In order not to affect the centrifugal effect of the centrifuge bucket, the inner wall of the centrifuge bucket needs to be cleaned. However, in the prior art, the inner wall of the centrifuge bucket on most centrifuges is cleaned manually, which not only increases the workload of the staff, but also reduces the cleaning efficiency of the centrifuge bucket, thereby affecting the use effect of the centrifuge. Utility Model Content

[0004] The utility model aims to provide a centrifuge for preparing gadolinium contrast agent raw materials to solve the problems raised in the background technology.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a centrifuge for preparing gadolinium contrast agent raw materials, comprising a centrifuge body and a scraping assembly; wherein the centrifuge body comprises a body, a feed pipe, a discharge block, a drive motor, a transmission shaft and a centrifuge barrel body; the feed pipe is fixedly arranged on the body; the discharge block is fixedly arranged on the side of the body away from the feed pipe; the drive motor is fixedly arranged on the body through a motor seat, and the output end of the drive motor extends through the body into the body; one end of the transmission shaft is fixedly connected to the output end of the drive motor; the centrifuge body comprises a centrifuge body, a feed pipe, a discharge block, a drive motor, a transmission shaft and a centrifuge barrel body; the feed pipe is fixedly arranged on the body; the discharge block is fixedly arranged on the side of the body away from the feed pipe; the drive motor is fixedly arranged on the body through a motor seat, and the output end of the drive motor extends into the body; one end of the transmission shaft is fixedly connected to the output end of the drive motor; The core barrel body is fixedly connected to the other end of the transmission shaft, and the output end of the feed pipe is arranged in the centrifugal barrel body; the scratch assembly is arranged in the body; wherein, the scratch assembly includes a fixed plate, a movable groove, a movable plate, a spring and a scraper; the fixed plate is fixedly arranged on the inner wall of the body; a movable groove is opened on one side of the fixed plate; the movable plate is slidably arranged in the movable groove; at least one of the two ends of the spring is respectively fixedly connected to the inner wall of the movable groove and the movable plate; the scraper is fixedly arranged on the side of the movable plate away from the spring; wherein, the scraper is in contact with the inner wall of the centrifugal barrel body.

[0006] As a preferred embodiment, the discharging block is a hollow truncated cone structure, and the size of the discharging block close to the machine body is larger than the size of the discharging block away from the machine body.

[0007] As a preferred embodiment, the scraper has an inclined structure.

[0008] As a preferred embodiment, it further comprises a collecting component; the collecting component is arranged on the machine body.

[0009] As a preferred embodiment, the collecting component includes an open groove, a collecting block, a collecting groove and a debris collecting groove; an open groove is opened on the circumferential surface of the machine body; the collecting block is inserted into the open groove; a collecting groove is opened on the collecting block; and a debris collecting groove is opened on the side of the scraper away from the movable plate.

[0010] As a preferred embodiment, the collecting block is in an arc-shaped structure, and the collecting block is in contact with the outer wall of the centrifuge barrel body.

[0011] As a preferred embodiment, the impurity collecting groove is in a U-shaped structure, and the lengths of two sides of the impurity collecting groove are different.

[0012] Compared with the prior art, the technical effects and advantages of the utility model are as follows:

[0013] The centrifuge used for preparing the raw material medicine of gadolinium contrast agent is provided with a scraping component. When in use, first, a driving motor is started to rotate the output shaft of the driving motor, the transmission shaft is rotated, the centrifuge barrel body is rotated, and the inner wall of the centrifuge barrel body is contacted with a scraper. Then, the raw material medicine of gadolinium contrast agent is added into the centrifuge barrel body through a feeding pipe. After the centrifuge barrel body is centrifuged, liquid and impurities in the raw material medicine of gadolinium contrast agent are separated, and the liquid is discharged from the discharge block. Impurities adhered to the inner wall of the centrifuge barrel body are scraped by the scraper, so that the centrifuge body can automatically clean the inner wall of the centrifuge barrel body during the centrifugation process, thereby greatly improving the working efficiency of the centrifuge body.

[0014] The centrifuge used for preparing a bulk drug of gadolinium contrast agent is provided with an open slot, a collecting block, a collecting slot and a collecting slot, so that impurities adhering to the inner wall of a centrifugal barrel body are scraped into the collecting slot by a scraper, and because the scraper is arranged obliquely, the impurities are allowed to enter the collecting slot along the collecting slot, until the gadolinium contrast agent bulk drug is centrifuged, and the driving motor is controlled so that the output shaft of the driving motor stops rotating. At this time, the handle on the collecting block is pulled to make the collecting block slide in the open slot until the collecting block is separated from the open slot, so that the impurities in the collecting block can be cleaned, and then the collecting block is inserted into the open slot so that the collecting block contacts the outer wall of the centrifugal barrel body. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the specific implementation methods of the utility model or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0016] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0017] Figure 2 It is a cross-sectional view of the overall structure of the utility model;

[0018] Figure 3 It is a partial structural split cross-sectional view of the utility model;

[0019] Figure 4 This is a split cross-sectional view of the scratch component structure of the utility model;

[0020] Figure 5 For the utility model Figure 2 Enlarged schematic diagram at point A in the middle.

[0021] Description of reference numerals:

[0022] In the figure:

[0023] 1. Centrifuge body; 2. Scratching assembly; 3. Collection assembly;

[0024] 101, machine body; 102, feed pipe; 103, discharge block; 104, drive motor; 105, transmission shaft; 106, centrifugal barrel body;

[0025] 201, fixed plate; 202, movable groove; 203, movable plate; 204, spring; 205, scraper;

[0026] 301, open slot; 302, collecting block; 303, collecting slot; 304, collecting slot. DETAILED DESCRIPTION

[0027] In the following description, a large number of specific details are given to provide a more thorough understanding of the utility model. However, it is obvious to those skilled in the art that the utility model can be implemented without one or more of these details. In other examples, in order to avoid confusion with the utility model, some technical features known in the art are not described.

[0028] Unless otherwise defined, the directions of up, down, left, right, front, back, inside and outside involved in this document are based on the directions of up, down, left, right, front, back, inside and outside in the figures shown in the present utility model, and are explained here together.

[0029] The connection method can be bonding, welding, bolt connection, etc., depending on actual needs.

[0030] See also Figures 1 to 5 As shown, this embodiment includes a centrifuge body 1 and a scratching assembly 2;

[0031] The centrifuge body 1 includes a body 101, a feed pipe 102, a discharge block 103, a drive motor 104, a transmission shaft 105 and a centrifugal barrel body 106; the feed pipe 102 is fixed on the body 101; the discharge block 103 is fixed on the side of the body 101 away from the feed pipe 102; the drive motor 104 is fixed on the body 101 through a motor seat, and the output end of the drive motor 104 passes through the body 101 and extends into the body 101; one end of the transmission shaft 105 is fixedly connected to the output end of the drive motor 104; the centrifugal barrel body 106 is fixedly connected to the other end of the transmission shaft 105, and the output end of the feed pipe 102 is arranged in the centrifugal barrel body 106;

[0032] The scratch component 2 is arranged in the body 101; wherein, the scratch component 2 includes a fixed plate 201, a movable groove 202, a movable plate 203, a spring 204 and a scraper 205; the fixed plate 201 is fixed on the inner wall of the body 101; a movable groove 202 is opened on one side of the fixed plate 201; the movable plate 203 is slidably arranged in the movable groove 202; five springs 204 are arranged in a linear array in the movable groove 202, and the two ends of the five springs 204 are respectively fixedly connected to the inner wall of the movable groove 202 and the movable plate 203; the scraper 205 is fixed on the side of the movable plate 203 away from the spring 204; wherein the scraper 205 contacts the inner wall of the centrifugal barrel body 106.

[0033] The utility model is provided with a scraping component 2. When in use, first, the driving motor 104 is started to rotate the output shaft of the driving motor 104, the transmission shaft 105 is rotated, the centrifugal barrel body 106 is rotated, and the inner wall of the centrifugal barrel body 106 is contacted with the scraper 205. Then, the gadolinium contrast agent API is added into the centrifugal barrel body 106 through the feeding pipe 102. After the centrifugal barrel body 106 is centrifuged, the liquid and impurities in the gadolinium contrast agent API are separated, and the liquid is discharged from the discharge block 103. Impurities adhered to the inner wall of the centrifugal barrel body 106 are scraped by the scraper 205, so that the centrifuge body 1 can automatically clean the inner wall of the centrifugal barrel body 106 during the centrifugation process, thereby greatly improving the working efficiency of the centrifuge body 1.

[0034] As a preferred embodiment, the discharge block 103 is a hollow truncated cone structure, and the size of the discharge block 103 close to the body 101 is larger than the size of the discharge block 103 away from the body 101, so as to facilitate the discharge and collection of the liquid in the gadolinium contrast agent API after centrifugation.

[0035] As a preferred embodiment, the scraper 205 is in an inclined structure, so as to facilitate the upward movement of impurities adhering to the inner wall of the centrifugal barrel body 106.

[0036] As a preferred embodiment, it also includes a collecting component 3; the collecting component 3 is arranged on the body 101; wherein the collecting component 3 includes an open groove 301, a collecting block 302, a collecting groove 303 and a collecting groove 304; an open groove 301 is provided on the circumferential surface of the body 101; the collecting block 302 is inserted into the open groove 301; a collecting groove 303 is provided on the collecting block 302; a collecting groove 304 is provided on the side of the scraper 205 away from the movable plate 203; wherein the collecting block 302 is in an arc-shaped structure, and the collecting block 302 is in contact with the outer wall of the centrifugal barrel body 106; wherein the collecting groove 304 is in a U-shaped structure, and the length dimensions of the two sides of the collecting groove 304 are different.

[0037] The utility model provides an open groove 301, a collecting block 302, a collecting groove 303 and a collecting groove 304, so that impurities adhered to the inner wall of the centrifugal barrel body 106 are scraped into the collecting groove 304 by the scraper 205, and because the scraper 205 is inclined, the impurities are allowed to enter the collecting groove 303 along the collecting groove 304, until the gadolinium contrast agent API is centrifuged, the driving motor 104 is controlled so that the output shaft of the driving motor 104 no longer rotates, at this time, the handle on the collecting block 302 is pulled to slide the collecting block 302 in the open groove 301 until the collecting block 302 is separated from the open groove 301, so that the impurities in the collecting block 302 can be cleaned, and then, the collecting block 302 is inserted into the open groove 301 so that the collecting block 302 contacts the outer wall of the centrifugal barrel body 106.

[0038] The driving motor 104 is a conventional instrument, and its working principle, size and model are irrelevant to the problem solved by the present application, so no further description will be given. The control method of the present invention is controlled by a controller, and the control circuit of the controller can be realized by simple programming by technicians in this field. The provision of power is also common knowledge in this field, and the present invention is mainly used to protect mechanical devices, so the present invention will no longer explain the control method and circuit connection in detail.

[0039] How it works

[0040] When the centrifuge for preparing the bulk drug of gadolinium contrast agent is used, first, the driving motor 104 is started to rotate the output shaft of the driving motor 104, the transmission shaft 105 is rotated, the centrifuge barrel body 106 is rotated, and the inner wall of the centrifuge barrel body 106 is contacted with the scraper 205. Then, the bulk drug of gadolinium contrast agent is added into the centrifuge barrel body 106 through the feeding pipe 102. After the centrifuge barrel body 106 is centrifuged, the liquid and impurities in the bulk drug of gadolinium contrast agent are separated, and the liquid is discharged from the discharging block 103, while the impurities adhering to the inner wall of the centrifuge barrel body 106 are scraped by the scraper 205. After entering the impurity collecting groove 304, since the scraper 205 is inclined, the impurities will flow into the collecting groove 303 along the impurity collecting groove 304 until the gadolinium contrast agent API is centrifuged. Then, the driving motor 104 is controlled so that the output shaft of the driving motor 104 no longer rotates. At this time, the handle on the collecting block 302 is pulled to slide the collecting block 302 in the opening groove 301 until the collecting block 302 is separated from the opening groove 301. Then, the impurities in the collecting block 302 can be cleaned. Then, the collecting block 302 is inserted into the opening groove 301 so that the collecting block 302 contacts the outer wall of the centrifugal barrel body 106.

[0041] It should be noted that, in this article, relational terms such as one and two are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions. The sentence "includes an element defined by ... does not exclude the existence of other identical elements in the process, method, article or device including the element".

[0042] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A centrifuge for preparing a gadolinium contrast agent API, characterized in that: include: Centrifuge body (1); The centrifuge body (1) comprises a body (101), a feed pipe (102), a discharge block (103), a drive motor (104), a transmission shaft (105) and a centrifuge barrel body (106); the feed pipe (102) is fixedly arranged on the body (101); the discharge block (103) is fixedly arranged on a side of the body (101) away from the feed pipe (102); the drive motor (104) is fixedly arranged on the body (101) via a motor seat, and an output end of the drive motor (104) passes through the body (101) and extends into the body (101); one end of the transmission shaft (105) is fixedly connected to the output end of the drive motor (104); the centrifuge barrel body (106) is fixedly connected to the other end of the transmission shaft (105), and the output end of the feed pipe (102) is arranged in the centrifuge barrel body (106); A scratch component (2) arranged in the machine body (101); The scraping assembly (2) comprises a fixed plate (201), a movable groove (202), a movable plate (203), a spring (204) and a scraper (205); the fixed plate (201) is fixedly arranged on the inner wall of the body (101); a movable groove (202) is provided on one side of the fixed plate (201); the movable plate (203) is slidably arranged in the movable groove (202); at least one of the two ends of the spring (204) is respectively fixedly connected to the inner wall of the movable groove (202) and the movable plate (203); the scraper (205) is fixedly arranged on the side of the movable plate (203) away from the spring (204); and the scraper (205) is in contact with the inner wall of the centrifugal barrel body (106).

2. A centrifuge for preparing a gadolinium contrast agent API according to claim 1, characterized in that: The discharge block (103) is a hollow truncated cone structure, and the size of the side of the discharge block (103) close to the machine body (101) is larger than the size of the side of the discharge block (103) away from the machine body (101).

3. A centrifuge for preparing a gadolinium contrast agent API according to claim 1, characterized in that: The scraper (205) has an inclined structure.

4. A centrifuge for preparing a gadolinium contrast agent API according to claim 2, characterized in that: Also includes: The collecting component (3) is arranged on the machine body (101).

5. A centrifuge for preparing a gadolinium contrast agent API according to claim 4, characterized in that: The collecting component (3) comprises: An open groove (301) is provided on the circumferential surface of the machine body (101); A collecting block (302) is inserted into the opening slot (301); The collecting block (302) is provided with a collecting groove (303); A debris collecting groove (304) is provided on a side of the scraper (205) away from the movable plate (203).

6. A centrifuge for preparing a gadolinium contrast agent API according to claim 5, characterized in that: The collecting block (302) has an arc-shaped structure, and the collecting block (302) is in contact with the outer wall of the centrifugal bucket body (106).

7. A centrifuge for preparing a gadolinium contrast agent API according to claim 5, characterized in that: The debris collecting groove (304) has a U-shaped structure, and the lengths of two sides of the debris collecting groove (304) are different.