Tumor tissue dicing device

Abstract

The utility model relates to the technical field of medical instruments, in particular to a tumor tissue dicing device which is characterized in that an opening is formed in the top of a box body, two sliding grooves are formed in the inner wall of the box body, and the two sliding grooves are symmetrically formed in the height direction of the box body; the knife rest is horizontally erected in the box body, and a plurality of blades are erected in the knife rest, are arranged at equal intervals and are distributed in a criss-cross manner in a latticed manner; the pressing plate is horizontally erected in the box body and located above the tool rest, sliding blocks are arranged at the two ends of the pressing plate respectively, and the two sliding blocks are in sliding connection with the two sliding grooves respectively; the lifting assembly is provided with a lifting part, and the lifting part of the lifting assembly is connected with the pressing plate. The tumor tissue cutting device has the advantages that the lifting assembly is used for driving the pressing plate to move downwards in the sliding groove, the pressing plate is made to cut tumor tissue on the knife rest, due to the fact that the blades are evenly arranged at intervals, uniform and fine tissue fragments can be rapidly obtained, the sizes of the tissue fragments are consistent, and follow-up research is facilitated.

Description

Technical Field

[0001] The utility model relates to the technical field of medical instruments, in particular to a tumor tissue cutting device. Background Art

[0002] With the development of medical research, primary tissue culture and primary cell culture play an increasingly important role in medical research. Compared with cell lines, primary cells can maintain the original characteristics of tissues to a greater extent. By studying primary cells, scientists can more easily reveal the pathogenesis of diseases and develop corresponding treatment strategies. Taking tumor research as an example, using primary cells, scientists can more easily discover the key pathological factors that drive tumor progression, reveal the key mechanisms of tumor cell resistance, and develop targeted drugs. However, in primary tissue culture and primary cell culture, there is a necessary step: the primary tissue needs to be cut into uniform small pieces. Only under this premise can subsequent related research be carried out.

[0003] The current conventional method is to use scissors to manually shear the tissue. The advantage of this method is that the implementation conditions are relatively simple, and only a pair of sterile scissors need to be prepared. However, the shortcomings of this method are also obvious. First, manual shearing is inefficient, and the shearing process requires researchers to spend a lot of time and energy. Second, due to the long operation time, the activity of primary tissues is reduced, which is not conducive to the subsequent acquisition of primary cells with better activity. In addition, the effects of manual shearing vary. The operating levels of different personnel vary greatly, and the final tissue blocks are of different sizes, and the consistency of experimental methods needs to be improved. In short, the shortcomings of manual shearing have brought many difficulties and challenges to primary tissue research. Now there is an urgent need for a simple tool that can quickly cut primary tissues into uniform small pieces. Utility Model Content

[0004] The purpose of the utility model is to overcome the problems existing in the above-mentioned prior art and provide a tumor tissue cutting device which can cut primary tumor tissue into uniform small pieces.

[0005] The technical solution of the utility model is:

[0006] A tumor tissue cutting device, comprising:

[0007] A box body, with an open top, an inner wall of which is provided with two slide grooves, the two slide grooves being symmetrically provided along a height direction of the box body;

[0008] A blade holder is horizontally mounted in the box, and a plurality of blades are mounted in the blade holder, the blades are arranged at equal intervals, and the blades are crisscrossed and distributed in a grid shape;

[0009] A pressing plate is horizontally mounted in the box, the pressing plate is located above the tool holder, two ends of the pressing plate are respectively provided with sliders, and the two sliders are respectively slidably connected with the two slide grooves;

[0010] The lifting assembly comprises a lifting part, wherein the lifting part of the lifting assembly is connected to the pressure plate, and the lifting assembly is used to drive the pressure plate to rise and fall in the slide groove. When the pressure plate slides to the bottom end of the slide groove, the bottom of the pressure plate abuts against the multiple blades on the tool holder.

[0011] Preferably, the lifting assembly comprises:

[0012] A first connecting rod, one end of which is connected to the pressing plate;

[0013] The first pressing handle has a middle portion hinged to the top of the box body, and the other end of the first connecting rod is hinged to one end of the first pressing handle.

[0014] Preferably, the lifting assembly comprises:

[0015] A cross bar is arranged horizontally, and one end of the cross bar is fixed to the side wall of the box body;

[0016] an arc-shaped rod, one end of which is hinged to the other end of the crossbar;

[0017] A second pressing handle, one end of which is connected to the other end of the arc-shaped rod;

[0018] A second connecting rod has one end connected to the pressing plate and the other end hinged to the middle portion of the second pressing handle.

[0019] Preferably, the interval between two adjacent blades is 0.5 mm-5 mm.

[0020] Preferably, the interval between two adjacent blades is 1 mm.

[0021] Preferably, the box body is a double-layer structure, and the cavity between the inner layer and the outer layer of the box body is used to contain the freezing liquid.

[0022] Preferably, the box body is divided into a first tube, a second tube and a third tube which are detachably connected in sequence from top to bottom, the first tube and the second tube are both open at both ends, the top end of the third tube is open and the bottom end is closed, the tool holder is mounted on the inner wall of the second tube, and the slide groove is opened on the inner walls of the first tube and the second tube.

[0023] Preferably, a drawer is installed at the bottom of the third cylinder, and the drawer is used to store the cut tumor tissue.

[0024] Preferably, the top end of the second tube is provided with a first stop structure, and the bottom end of the first tube is provided with a second stop structure that matches and snaps into the first stop structure; the bottom end of the second tube is provided with a third stop structure, and the top end of the third tube is provided with a fourth stop structure that matches and snaps into the third stop structure.

[0025] Compared with the prior art, the tumor tissue cutting device provided by the utility model has the following beneficial effects:

[0026] When this device cuts tumor tissue, it first places the tumor tissue on the grid-shaped blade on the knife holder, and uses the lifting component to drive the pressure plate to move downward in the slide slot, so that the pressure plate cuts the tumor tissue on the knife holder. Because the blades are evenly spaced, it is conducive to quickly obtaining uniform and small tissue fragments, and each piece of tissue is of the same size, which is convenient for subsequent research. By setting up a lifting component, the pressure plate can be evenly forced to squeeze the tumor tissue, and the tissue can be cut into small pieces of uniform size at the same time, which has better effects and higher cutting efficiency. In addition, this device divides the box into three detachable structures, which is easy to disassemble and clean and is also easy to install, avoiding mutual contamination between different samples. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a schematic diagram of the structure of the utility model;

[0028] Figure 2 This is another structural schematic diagram of the lifting assembly of the utility model;

[0029] Figure 3 It is a top view of the tool holder of the utility model;

[0030] Figure 4 It is a structural schematic diagram of the box body of the utility model. DETAILED DESCRIPTION

[0031] The utility model provides a tumor tissue cutting device, which is combined with Figures 1 to 4 The utility model is described with reference to the structural schematic diagram, but it should be understood that the protection scope of the utility model is not limited by the specific implementation methods.

[0032] Example 1

[0033] like Figure 1As shown, the tumor tissue cutting device provided by the utility model comprises: a box body 1, a knife holder 2, a pressing plate 3, and a lifting assembly 4. The box body 1 serves as a supporting member of the entire device, the top of the box body 1 is open, and the inner wall of the box body 1 is provided with two slide grooves 11, and the two slide grooves 11 are symmetrically provided along the height direction of the box body 1; the knife holder 2 is horizontally mounted in the box body 1, and a plurality of blades 21 are mounted in the knife holder 2, and the blades 21 are used to cut tumor tissues, and the blades 21 are long strips, and the plurality of blades 21 are arranged at equal intervals, and as shown in FIG. Figure 3 As shown, multiple blades 21 are crisscrossed and distributed in a grid shape, that is, multiple blades 21 form a grid-shaped tool holder, so that the cut tumor tissue is uniform in size; the pressing plate 3 is horizontally mounted in the box body 1, and the pressing plate 3 is located above the tool holder 2. Slide blocks 31 are respectively provided at both ends of the pressing plate 3, and the two slide blocks 31 are respectively slidably connected to the two slide grooves 11, and the pressing plate 3 can slide in the slide grooves 11 with the slide blocks 31; the lifting component 4 has a lifting part, and the lifting part of the lifting component 4 is connected to the pressing plate 3. The lifting component 4 is used to drive the pressing plate 3 to rise and fall in the slide groove 11, so that the pressing plate 3 squeezes downward to cut the tumor tissue into pieces. When the pressing plate 3 slides to the bottom of the slide groove 11, the bottom of the pressing plate 3 abuts against the multiple blades 21 on the tool holder 2, so that when the pressing plate 3 slides downward, it can squeeze the tumor tissue until it completely passes through the blades 21 on the tool holder 2 to complete the cutting. When the device cuts tumor tissue, the tumor tissue is first placed on the grid-shaped blade 21 on the blade holder 2, and the lifting component 4 is used to drive the pressing plate 3 to move downward in the slide groove 11, so that the pressing plate 3 cuts the tumor tissue on the blade 21. Because the blades 21 are evenly spaced, it is beneficial to quickly obtain uniform and small tissue fragments, and each piece of tissue is of the same size, which is convenient for subsequent research.

[0034] like Figure 2 As shown, this embodiment provides a specific structure of a lifting assembly 4. Furthermore, the lifting assembly 4 includes: a first connecting rod 41 and a first pressing handle 42. One end of the first connecting rod 41 is connected to the pressing plate 3; the middle part of the first pressing handle 42 is hinged to the top of the box body 1, so that the first pressing handle 42 forms a lever, and the other end of the first connecting rod 41 is hinged to one end of the first pressing handle 42. By pressing or lifting the end of the first pressing handle 42 away from the first connecting rod 41, the first connecting rod 41 is pressed down or lifted. The specific process of moving the pressing plate 3 is: the medical staff holds the first pressing handle 42 and lifts it upward, so that the first connecting rod 41 is pressed down to drive the pressing plate 3 to move downward in the slide groove 11, so that the pressing plate 3 squeezes and cuts the tumor tissue; after the cutting is completed, the first pressing handle 42 is held and pressed down, so that the first connecting rod 41 is lifted and the pressing plate 3 is lifted, and then another piece of tumor tissue to be cut is placed on the knife holder 2 for cutting.

[0035] like Figure 3As shown, further, the interval between two adjacent blades 21 is 0.5mm-5mm. The distance between the blades is related to the size of the tumor tissue block that needs to be cut, and a knife holder with a suitable density can be selected according to actual needs. Among them, handles are provided on both sides of the knife holder 2 to facilitate the removal of the entire knife holder.

[0036] Furthermore, the interval between two adjacent blades 21 is 1 mm, and the tumor tissue block cut out is 1 mm. 3 , which is the size commonly used in detection research.

[0037] Furthermore, the box 1 is a double-layer structure, and the cavity between the inner layer and the outer layer of the box 1 is used to hold the freezing liquid. The box 1 can be placed in a refrigerator for freezing before use, and when it is brought to room temperature for use, the freezing liquid can keep the tool at a low temperature, which is conducive to maintaining tissue activity.

[0038] Example 2

[0039] As a further alternative to Embodiment 1, this embodiment provides another specific structure of the lifting assembly 4, such as Figure 1 As shown, further, the lifting assembly 4 includes: a cross bar, an arc-shaped rod 43, a second pressing handle 44, and a second connecting rod 45. The cross bar is arranged horizontally, and one end of the cross bar is fixed on the side wall of the box body 1; one end of the arc-shaped rod 43 is hinged to the other end of the cross bar, and the arc-shaped rod 43 can rotate relative to one end of the cross bar; one end of the second pressing handle 44 is connected to the other end of the arc-shaped rod 43; one end of the second connecting rod 45 is connected to the pressing plate 3, and the second connecting rod 45 can be hinged to the pressing plate 3, and the other end is hinged to the middle part of the second pressing handle 44. The specific process of moving the pressing plate 3 is: the medical staff manually presses the second pressing handle 44 downward, so that the second connecting rod 45 drives the pressing plate 3 to move downward in the slide groove 11, so that the pressing plate 3 cuts the tumor tissue on the knife holder.

[0040] Compared with the lifting assembly in Embodiment 1, the lifting assembly 4 in this embodiment simplifies the process of moving the pressing plate 3 upward, has better effect and higher cutting efficiency.

[0041] Among them, this embodiment only replaces the lifting component 4 in the embodiment 1, and other structures remain unchanged.

[0042] Example 3

[0043] As a further improvement scheme based on Example 1, the box body 1 is further divided from top to bottom into a first tube 12, a second tube 13 and a third tube 14 which are detachably connected in sequence. Both ends of the first tube 12 and the second tube 13 are open, and they are through-hole structures. The top end of the third tube 14 is open and the bottom end is closed, so that the inner cavity of the third tube 14 forms a groove structure. The knife holder 2 is mounted on the inner wall of the second tube 13, and the slide groove 11 is provided on the inner walls of the first tube 12 and the second tube 13. By dividing the box body 1 into three sections of detachable structures, it is easy to disassemble and clean, and it is also easy to install. Among them, the knife holder 2 of the device can be detachable from the inner wall of the second tube 13, such as plug-in and other detachable methods, so that the entire knife holder 2 can be removed, and it can be disassembled for cleaning after cutting the tumor tissue, and at the same time, mutual contamination between different samples is avoided.

[0044] Furthermore, a drawer 5 is installed at the bottom of the third cylinder 14. The top of the drawer 5 is open. The drawer 5 is located below the knife holder 2. The drawer 5 can receive the cut tumor tissue and store the cut tumor tissue. At the same time, the drawer 5 can be disassembled to facilitate cleaning and transfer of the cut tissue to avoid mutual contamination between different samples.

[0045] like Figure 4 As shown, further, the top of the second tube 13 is provided with a first stop structure, and the bottom of the first tube 12 is provided with a second stop structure that matches and snaps with the first stop structure; the bottom of the second tube 13 is provided with a third stop structure, and the top of the third tube 14 is provided with a fourth stop structure that matches and snaps with the third stop structure. Among them, the connection structure between the second stop structure and the first stop structure, and the connection structure between the third stop structure and the fourth stop structure are the same, and the detachable connection between the second tube 13 and the first tube 12 is realized by the second stop structure and the first stop structure, and the detachable connection between the second tube 13 and the third tube 14 is realized by the third stop structure and the fourth stop structure.

[0046] Among them, other structures of this embodiment are consistent with those of embodiment 1, and are just optimizations made to embodiment 1.

[0047] The advantage of the utility model is that when the device cuts the tumor tissue, the tumor tissue is first placed on the grid-shaped blades on the tool holder, and the lifting assembly is used to drive the pressure plate to move downward in the slide slot, so that the pressure plate cuts the tumor tissue on the tool holder. Because the blades are evenly spaced, it is conducive to quickly obtaining uniform and small tissue fragments, and each piece of tissue is of the same size, which is convenient for subsequent research. By setting up the lifting assembly, the pressure plate can be evenly forced to squeeze the tumor tissue, and the tissue can be cut into small pieces of uniform size at the same time, which has better effects and higher cutting efficiency. In addition, the device divides the box into three detachable structures, which is easy to disassemble and clean and is also easy to install, avoiding mutual contamination between different samples.

[0048] The above disclosures are only several specific embodiments of the present invention. However, the embodiments of the present invention are not limited thereto. Any changes that can be conceived by those skilled in the art should fall within the protection scope of the present invention.

Claims

1. A tumor tissue cutting device, characterized in that: include: A box body (1) is open at the top, and two slide grooves (11) are provided on the inner wall of the box body (1), and the two slide grooves (11) are symmetrically provided along the height direction of the box body (1); A blade holder (2) is horizontally mounted in the box body (1), and a plurality of blades (21) are mounted in the blade holder (2), the plurality of blades (21) are arranged at equal intervals, and the plurality of blades (21) are crisscrossed and distributed in a grid shape; A pressure plate (3) is horizontally mounted in the box body (1), the pressure plate (3) is located above the tool holder (2), and two ends of the pressure plate (3) are respectively provided with sliders (31), and the two sliders (31) are respectively slidably connected to the two slide grooves (11); A lifting component (4) comprises a lifting part, wherein the lifting part of the lifting component (4) is connected to the pressing plate (3), and the lifting component (4) is used to drive the pressing plate (3) to move up and down in the sliding groove (11). When the pressing plate (3) slides to the bottom end of the sliding groove (11), the bottom of the pressing plate (3) abuts against a plurality of blades (21) on the tool holder (2).

2. The tumor tissue cutting device according to claim 1, characterized in that: The lifting assembly (4) comprises: A first connecting rod (41), one end of which is connected to the pressing plate (3); The first pressing handle (42) has a middle portion hinged to the top of the box body (1), and the other end of the first connecting rod (41) is hinged to one end of the first pressing handle (42).

3. The tumor tissue cutting device according to claim 1, characterized in that: The lifting assembly (4) comprises: A cross bar, arranged horizontally, one end of which is fixed to the side wall of the box body (1); An arc-shaped rod (43), one end of which is hinged to the other end of the cross rod; A second pressing handle (44), one end of which is connected to the other end of the arc-shaped rod (43); A second connecting rod (45) has one end connected to the pressing plate (3) and the other end hinged to the middle of the second pressing handle (44).

4. The tumor tissue cutting device according to claim 1, characterized in that: The interval between two adjacent blades (21) is 0.5 mm to 5 mm.

5. The tumor tissue cutting device according to claim 4, characterized in that: The interval between two adjacent blades (21) is 1 mm.

6. The tumor tissue cutting device according to claim 1, characterized in that: The box body (1) is a double-layer structure, and the cavity between the inner layer and the outer layer of the box body (1) is used to contain the freezing liquid.

7. The tumor tissue cutting device according to claim 1, characterized in that: The box body (1) is divided from top to bottom into a first tube (12), a second tube (13) and a third tube (14) which are detachably connected in sequence. Both ends of the first tube (12) and the second tube (13) are open, and the top end of the third tube (14) is open and the bottom end is closed. The tool holder (2) is mounted on the inner wall of the second tube (13), and the slide groove (11) is opened on the inner walls of the first tube (12) and the second tube (13).

8. The tumor tissue cutting device according to claim 7, characterized in that: A drawer (5) is installed at the bottom of the third cylinder (14), and the drawer (5) is used to store the cut tumor tissue.

9. The tumor tissue cutting device according to claim 7, characterized in that: The top end of the second tube (13) is provided with a first stop structure, and the bottom end of the first tube (12) is provided with a second stop structure that matches and snaps together with the first stop structure; the bottom end of the second tube (13) is provided with a third stop structure, and the top end of the third tube (14) is provided with a fourth stop structure that matches and snaps together with the third stop structure.

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