Perfusion device capable of continuously cleaning miniature axial flow blood pump

Abstract

The utility model discloses a filling device capable of continuously cleaning a miniature axial flow blood pump, which comprises a filling box, a driving device and a hydraulic cylinder piece, the hydraulic cylinder piece is arranged in the filling box, a cylinder barrel of the hydraulic cylinder piece is divided into a liquid inlet groove, a piston groove and a liquid outlet groove through two partition plates, a liquid inlet hole is arranged on an end plate on one side of the cylinder barrel corresponding to the liquid inlet groove, and a liquid outlet hole is arranged on the end plate on the other side of the cylinder barrel corresponding to the piston groove. A liquid inlet and outlet hole is formed in the end plate, corresponding to the liquid outlet groove, of the other side of the cylinder barrel, the end plate on the side is opposite to the end plate on the other side, the liquid inlet hole is obliquely opposite to the liquid outlet hole, and one-way valves, namely the first one-way valve, the second one-way valve, the third one-way valve and the fourth one-way valve are installed at the four ends of the two partition plates respectively. The first one-way valve and the second one-way valve are installed on one partition plate, the third one-way valve and the fourth one-way valve are installed on the other partition plate, the piston is located in the piston groove and reciprocates between liquid inlets of the first one-way valve and the second one-way valve and between liquid outlets of the third one-way valve and the fourth one-way valve, and the liquid inlet hole is connected with the liquid inlet connector.

Description

Technical Field

[0001] The utility model relates to a perfusion device capable of continuously cleaning a micro axial flow blood pump. Background Art

[0002] Cardiorenal syndrome refers to a clinical syndrome in which acute or chronic dysfunction of the heart or kidney induces acute or chronic dysfunction of another organ. More than 60% of patients hospitalized for acute decompensated heart failure exhibit moderate to severe chronic kidney disease at the time of admission. The pathophysiological mechanism of abnormal renal function in heart failure is quite complex, and one of the most important factors is insufficient renal vascular perfusion. Effectively improving the treatment level of patients with cardiorenal syndrome has become a major clinical need. Micro-axial flow blood pumps have become the greatest possibility for improving renal perfusion and assisting blood circulation in patients with heart failure. A multicenter efficacy study showed that micro-axial flow blood pumps can help increase urine output and improve renal function in patients with cardiorenal syndrome. The micro-axial flow blood pump is a percutaneous ventricular assist device that can be quickly implanted through minimally invasive surgery under the guidance and monitoring of imaging equipment to provide continuous blood flow from the left ventricle through the aortic valve to the ascending aorta.

[0003] The shaft of the impeller of the micro axial flow blood pump rotates at high speed on the bearing, converting mechanical energy into kinetic energy of blood. There is a bearing cavity in the space between the impeller shaft and the bearing. Blood may enter the bearing cavity to form thrombus or damage the motor, thus affecting the normal operation of the blood pump. In order to prevent blood from entering the pump, most of the existing technologies at home and abroad use cleaning pipelines to inject cleaning fluid into the pump to prevent blood from entering and inhibit thrombus formation in the equipment, while also lubricating the internal high-speed rotating bearings.

[0004] The existing perfusion and cleaning device is mainly arranged in a plunger pump in a box, and the linear reciprocating motion of the plunger of the plunger pump is controlled by a motor, and a one-way valve is used to realize the suction and perfusion of the cleaning liquid, and 5% glucose or sodium bicarbonate solution is perfused into the blood pump in vitro. For example, the Chinese invention patent application with publication number CN115807766A discloses a plunger pump zero position calibration method, a blood pump perfusion and cleaning device, and a blood pump system, which achieves good cleaning of the blood pump, but the one-way plunger pump used cannot achieve continuous perfusion of the cleaning liquid. The reason is that the cleaning pipeline of the plunger pump will be depressurized during the process of pumping the cleaning liquid. In order to prevent blood from entering the blood pump, it is necessary to add an additional balloon structure with hydraulic energy storage to maintain the hydraulic pressure of the cleaning pipeline. It can be seen that it has the following defects: the liquid pressure cannot be guaranteed to be stable through the balloon structure, and the intermittent supply of cleaning liquid obviously has the risk of blood entering the blood pump. In addition, the cleaning fluid flow of the one-way plunger pump is uneven, and the piston speed needs to be accelerated during the cleaning fluid suction process to reduce the cleaning fluid suction time. However, the piston acceleration during suction will easily wear the piston and piston cylinder of the plunger pump. Utility Model Content

[0005] The utility model provides a perfusion device which can continuously clean a micro axial flow blood pump, and effectively solves the problem of discontinuity and uneven perfusion cleaning flow rate.

[0006] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0007] A perfusion device for continuously cleaning a micro axial flow blood pump comprises a perfusion box, a driving device and a hydraulic cylinder. The hydraulic cylinder is installed in the perfusion box. The cylinder barrel of the hydraulic cylinder is divided into a liquid inlet groove, a piston groove and a liquid outlet groove by two partitions. A liquid inlet hole is provided on an end plate on one side of the cylinder barrel corresponding to the liquid inlet groove, and a liquid outlet hole is provided on an end plate on the other side of the cylinder barrel corresponding to the liquid outlet groove. The end plate on one side is opposite to the end plate on the other side, and the liquid inlet hole is obliquely opposite to the liquid outlet hole. A one-way valve is respectively installed at the four ends of the two partitions, namely, a first one-way valve, a second one-way valve, The third one-way valve and the fourth one-way valve, the first one-way valve and the second one-way valve are installed on a partition, and the third one-way valve and the fourth one-way valve are installed on another partition. The piston is located in the piston groove and moves back and forth between the liquid inlets of the first one-way valve and the second one-way valve and between the liquid outlets of the third one-way valve and the fourth one-way valve. The liquid inlet hole is connected to the liquid inlet interface, the liquid inlet interface is connected to the liquid inlet pipe and extends out of the canning box, the liquid outlet hole is connected to the infusion interface and the infusion pipe, and the driving device is connected to the outer end of the piston rod of the hydraulic cylinder so that the piston rod moves back and forth.

[0008] Specifically, the driving device is a motor, a coupling and a transmission shaft assembly. The output shaft of the motor is connected to the transmission shaft of the transmission shaft assembly through a coupling. The transmission shaft assembly includes a transmission shaft clamp and a transmission shaft rotating member. The free end of the transmission shaft rotating member is provided with a driving gear. The transmission shaft clamp is sleeved on the optical axis of the transmission shaft rotating member. The transmission shaft clamp is rotatably mounted on a positioning member, and the positioning member is mounted on the bottom shell of the filling box. The top wall of the circular shaft at the outer end of the piston rod is provided with a rack belt meshing with the driving gear. The circular shaft is movably clamped on a limit seat installed on the bottom shell, and a slide groove is provided on the bottom wall of the circular shaft.

[0009] Specifically, the positioning member is three groove plates, an outer groove plate, a middle groove plate and an inner groove plate. The outer groove plate corresponds to the inner groove plate, the groove of the middle groove plate is larger than the inner and outer groove plates, and the transmission shaft clamp corresponds to the middle groove plate, and its two end walls are limited between the inner and outer groove plates so that the transmission shaft assembly cannot be axially displaced.

[0010] Specifically, the limit seat includes a plurality of support slot plates, a guide column is provided at the middle groove of the support slot plate, and a sliding groove is provided on the bottom wall of the circular shaft and slidably cooperates with the guide column.

[0011] Specifically, the displacement of each tooth of the rack belt is ±0.8 mm to 1.5 mm.

[0012] The beneficial effects of the utility model are: effectively solving the problems of discontinuous and uneven perfusion cleaning flow and large piston wear, and providing a sustainable and uniform cleaning fluid for the axial flow blood pump. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the embodiment of the utility model, the embodiment will be described below in conjunction with the accompanying drawings.

[0014] Figure 1 It is a schematic diagram of the external structure of the perfusion device of the utility model.

[0015] Figure 2 It is a schematic diagram of the internal structure of the perfusion device of the utility model.

[0016] Figure 3 It is a schematic diagram of the transverse section structure of the perfusion device of the utility model.

[0017] Figure 3A It is a schematic diagram of the bottom shell structure of the perfusion box.

[0018] Figure 4 It is a schematic diagram of the longitudinal section structure of the perfusion device of the utility model.

[0019] Figure 5A The figure shows the correct position of the piston in the pouring device of the utility model when pouring at the rightmost position.

[0020] Figure 5B The figure shows the correct position of the piston in the filling device of the utility model when filling at the far left side.

[0021] Figure 6 It is a structural schematic diagram of the connection between the perfusion device of the utility model and the micro axial flow blood pump.

[0022] 1-infusion box, 101-top shell, 102-bottom shell, 1011-protective cover, 1021-limit seat, 1020-guide column, 1022-positioning piece, 2-coupling, 3-drive shaft assembly, 301-drive shaft clamp, 302-drive shaft gear, 4-motor, 5-piston rod, 501-round shaft, 502-piston, 5011-slideway, 6-cylinder, 61 first baffle, 62, second baffle, 601-first one-way valve, 602-second one-way Valve, 603-the third one-way valve, 604-the fourth one-way valve, 605-the liquid inlet groove, 606-the piston groove, 607-the infusion groove, 608-the liquid inlet interface, 609-the infusion interface, 66-the liquid flow direction, 7-the liquid inlet tube, 701-the liquid bottle, 702-the first pressure sensor, 8-the infusion tube, 801-the liquid filter, 802-the second pressure sensor, 9-the micro axial flow blood pump, 901-the delivery pipeline, 902-the hub, 903-the power drive line. DETAILED DESCRIPTION

[0023] like Figure 1 to Figure 4 The invention discloses a perfusion device for continuously cleaning a micro-axial blood pump, comprising a perfusion box 1, a driving device and a hydraulic cylinder. The hydraulic cylinder is installed in the perfusion box. The cylinder barrel 6 of the hydraulic cylinder is separated into a liquid inlet groove 605, a piston groove 606 and a liquid outlet groove 607 by first and second partitions 61 and 62. A liquid inlet hole is provided on one end plate of the cylinder barrel corresponding to the liquid inlet groove 605, and a liquid outlet hole is provided on the other end plate of the cylinder barrel corresponding to the liquid outlet groove. The end plate on one side is opposite to the end plate on the other side, and the liquid inlet hole is obliquely opposite to the liquid outlet hole. A one-way valve is installed at each of the four ends of the two partitions, namely, the first The one-way valve 601, the second one-way valve 602, the third one-way valve 603 and the fourth one-way valve 604, the first one-way valve 601 and the second one-way valve 602 are installed on the first partition 61, the third one-way valve 603 and the fourth one-way valve 604 are installed on the second partition 62, the piston head of the piston rod is located in the piston groove and moves back and forth between the liquid inlets of the first one-way valve and the second one-way valve and between the liquid outlets of the third one-way valve and the fourth one-way valve, the liquid inlet hole is connected to the liquid inlet interface 608, the liquid inlet interface is connected to the liquid inlet pipe 7 and extends out of the filling box 1, the liquid outlet hole is connected to the infusion interface 609, and the infusion interface is connected to the infusion pipe 8. The driving device is connected to the outer end of the piston rod of the hydraulic cylinder so that the piston moves back and forth at a uniform speed.

[0024] The first one-way valve 601, the second one-way valve 602, the third one-way valve 603 and the fourth one-way valve 604 are all structures with the same function, which only allow the liquid to flow in one direction. The liquid inlet groove 605 is connected with the liquid inlet interface 608, allowing the external liquid to enter the liquid inlet groove 605 through the liquid inlet interface 608. Similarly, the infusion groove 607 is connected with the infusion interface 609, allowing the pressurized liquid to flow out of the infusion interface 609 through the infusion groove 607. The piston groove 606 is a cylindrical space, allowing the piston 502 to reciprocate linearly. The liquid inlet tube 7 is assembled with the liquid inlet interface 608, and the infusion tube 8 is assembled with the infusion interface 609.

[0025] The driving device includes a motor 4, a coupling 2 and a transmission shaft assembly 3, wherein the output shaft of the motor 4 is connected to the transmission shaft of the transmission shaft assembly 3 through the coupling 2, and the transmission shaft assembly 3 includes a transmission shaft clamp 301 and a transmission shaft rotating member 302, wherein a driving gear is provided at the free end of the transmission shaft rotating member 302, and the transmission shaft clamp 301 is sleeved on the optical axis of the transmission shaft rotating member 302, and the transmission shaft clamp 301 is rotatably mounted on the positioning member 1022; or The transmission shaft rotating member 302 is rotatably mounted on the transmission shaft clamp 301, and the transmission shaft clamp 301 is mounted on the positioning member 1022. At this time, the transmission shaft clamp 301 can be a bearing member. The positioning member 1022 is mounted on the bottom shell 102 of the filling box 1. A rack belt 501 meshing with a driving gear is provided on the top wall of the circular shaft at the outer end of the piston rod 5. The circular shaft is movably clamped on the limiting seat 1021 installed on the bottom shell, and a sliding groove 5011 is provided on the bottom wall of the circular shaft. The driving gear cooperates with the rack belt and is driven by the piston head 502 of the piston rod to continuously reciprocate linearly.

[0026] The positioning member 1022 is composed of three groove plates, an outer groove plate, a middle groove plate and an inner groove plate. The outer groove plate corresponds to the inner groove plate. The groove of the middle groove plate is larger than the inner and outer groove plates. The transmission shaft clamp corresponds to the middle groove plate, and the walls at both ends thereof are limited between the inner and outer groove plates so that the transmission shaft assembly cannot be axially displaced.

[0027] The limiting seat 1021 includes a plurality of supporting slot plates, and a guide column 1020 is provided at the arc groove in the middle of the supporting slot plate, and the bottom wall sliding groove of the circular shaft slides along the guide column.

[0028] The perfusion box 1 includes a top shell 101 and a bottom shell 102. The direction of rotation and the speed of the gear can be adjusted by adjusting the direction of rotation and the speed of the motor 4. The tooth displacement of the rack belt can be ±0.8mm to 1.5mm. Figure 3 As shown, when the transmission shaft assembly 3 rotates clockwise, it drives the piston rod 5 to move to the right; similarly, when the transmission shaft assembly 3 rotates counterclockwise, it drives the piston rod 5 to move to the left. The bottom wall of the circular shaft is provided with a slide groove 5011 to further limit the reciprocating range of the piston rod. The linear reciprocating motion of the piston 501 is a uniform reciprocating motion, which can reduce the wear on the piston surface.

[0029] like Figure 4 As shown, the top shell 101 of the perfusion box 1 is provided with a protective cover 1011 for protecting the transmission shaft and the driving gear to prevent accidental separation. The bottom shell 102 is provided with a limit seat 1021, which is equipped with a guide column. The guide column cooperates with the bottom slide groove 5011 of the round shaft to ensure that the piston rod only moves linearly and within a specified distance.

[0030] Figure 5A and Figure 5B The cross-sections of the piston rod 5 in two positions in the cylinder are shown. The first one-way valve 601 and the second one-way valve 602 of the cylinder only allow the cleaning liquid to flow from the piston groove 606 to the infusion groove 607; the third one-way valve 603 and the fourth one-way valve 604 of the cylinder only allow the cleaning liquid to flow from the inlet groove 605 to the piston groove 606. Figure 5A It shows that the piston rod 5 moves to the rightmost position. At this time, the pressure in the space on the left side of the piston groove 606 is lower than that in the liquid inlet groove 605, and the cleaning liquid enters the piston groove 606 from the liquid inlet groove 605 through the third one-way valve 603; the original liquid was squeezed to the right by the piston 502. At this time, the pressure in the space on the right side of the piston groove 606 is greater than that in the infusion groove 607, and the cleaning liquid enters the infusion groove 607 from the piston groove 606 through the second one-way valve 602; the first perfusion and cleaning process is completed. Figure 5B The piston rod 5 is shown to move to the leftmost position. At this time, the pressure of the space on the right side of the piston groove 606 is lower than that of the liquid inlet groove 605. The cleaning liquid enters the piston groove 606 from the liquid inlet groove 605 through the fourth one-way valve 604. The original liquid is squeezed to the left by the piston 502. At this time, the pressure of the space on the left side of the piston groove 606 is greater than that of the infusion groove 607. The cleaning liquid enters the infusion groove 607 from the piston groove 606 through the first one-way valve 601. The second perfusion and cleaning process is completed. Through the above structural design, no matter which direction the piston rod 5 moves, the cleaning liquid can enter from the liquid inlet interface 608 and flow out from the infusion interface 609, and finally realize the continuous perfusion of cleaning liquid to clean the blood pump.

[0031] like Figure 6 As shown, the schematic diagram of the structure of the perfusion device of the utility model connected to the micro-axial blood pump 9, the liquid bag 701 is used to provide cleaning liquid, and the first liquid flow pressure sensor 702 is used to monitor the flow rate of the cleaning liquid. The perfusion box 1 draws cleaning liquid from the liquid inlet tube 7 of the liquid bag 701, and converts the mechanical energy into the kinetic energy of the cleaning liquid under the action of the motor 4, and the pressurized cleaning liquid is transported from the infusion tube 8 to the remote micro-axial blood pump 9. Before the pressurized cleaning liquid is transported to the micro-axial blood pump 9, it will be pressure-monitored by the pressure sensor 802 to ensure that the perfused cleaning liquid meets the pressure requirements; and the liquid filter 801 will filter to ensure that impurities such as tiny particles do not enter the blood pump. It is further explained that the cleaning liquid includes but is not limited to heparin, glucose solution or sodium bicarbonate solution.

[0032] The micro-axial blood pump 9 delivers power through a power drive line 903, which merges with the infusion tube 8 in a hub 902, and is assembled into a single double-lumen delivery pipeline 901 connected to the proximal end of the blood pump. The micro-axial blood pump 9 is a percutaneously delivered, catheter-mounted axial flow pump located in the descending aorta. The device is a small rotary impeller installed in a self-expanding nitinol strut anchoring system, which is connected to the motor controller via a thin and soft power drive line 903. When activated, the high-speed jet at its outlet accelerates the native aortic flow and entrains blood flow, thereby forming a trans-aortic gradient. The micro-axial blood pump 9 can refer to patent publication number CN215585245U. The motor of the micro-axial blood pump 9 will heat up, wear, and blood will enter the motor during operation, causing damage to the blood pump, so it is necessary to continuously and uniformly perfuse high-pressure cleaning liquid into the blood pump.

Claims

1. A perfusion device for continuously cleaning a micro axial flow blood pump, characterized in that: The hydraulic cylinder part comprises a filling box, a driving device and a hydraulic cylinder part, wherein the hydraulic cylinder part is installed in the filling box, and the cylinder barrel of the hydraulic cylinder part is divided into a liquid inlet groove, a piston groove and a liquid outlet groove by two partitions, a liquid inlet hole is provided on one side end plate of the cylinder barrel corresponding to the liquid inlet groove, and a liquid outlet hole is provided on the other side end plate of the cylinder barrel corresponding to the liquid outlet groove, the one side end plate is opposite to the other side end plate, the liquid inlet hole is obliquely opposite to the liquid outlet hole, and a one-way valve is respectively installed on the four ends of the two partitions, namely the first one-way valve, the second one-way valve, the third one-way valve and the fourth one-way valve, the first one-way valve and the second one-way valve are installed on a partition, and the third one-way valve and the fourth one-way valve are installed on the other partition, the piston is located in the piston groove and moves back and forth between the liquid inlets of the first one-way valve and the second one-way valve and between the liquid outlets of the third one-way valve and the fourth one-way valve, the liquid inlet hole is connected to the liquid inlet interface, the liquid inlet interface is connected to the liquid inlet pipe and extends out of the canning box, and the outlet The liquid hole is connected to an infusion interface, which is connected to an infusion tube, and the driving device is connected to the outer end of the piston rod of the hydraulic cylinder so that the piston rod can reciprocate; the driving device is a motor, a coupling and a transmission shaft assembly, the output shaft of the motor is connected to the transmission shaft of the transmission shaft assembly through a coupling, the transmission shaft assembly includes a transmission shaft clamp and a transmission shaft rotating member, the free end of the transmission shaft rotating member is provided with a driving gear, the transmission shaft clamp is sleeved on the optical axis of the transmission shaft rotating member, the transmission shaft clamp is rotatably mounted on a positioning member, and the positioning member is mounted on the bottom shell of the filling box, the top wall of the circular shaft at the outer end of the piston rod is provided with a rack belt meshing with the driving gear, the circular shaft is movably clamped on a limiting seat installed on the bottom shell, and a slide groove is provided on the bottom wall of the circular shaft, the limiting seat includes a plurality of supporting slot plates, a guide column is provided at the middle groove of the supporting slot plate, and the slide groove on the bottom wall of the circular shaft is slidably matched with the guide column.

2. The perfusion device for continuously cleaning a micro axial flow blood pump according to claim 1, characterized in that: The positioning member is composed of three groove plates, an outer groove plate, a middle groove plate and an inner groove plate. The outer groove plate corresponds to the inner groove plate. The groove of the middle groove plate is larger than the inner and outer groove plates. The transmission shaft clamp corresponds to the middle groove plate, and the walls at both ends thereof are limited between the inner and outer groove plates so that the transmission shaft assembly cannot be axially displaced.

3. The perfusion device for continuously cleaning a micro axial flow blood pump according to claim 1, characterized in that: The displacement of each tooth of the rack belt is ±0.8mm~1.5mm.

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