Rat brain stereotactic injection device

Abstract

The utility model relates to a rat brain three-dimensional positioning injection device which comprises a bottom plate, a guide plate and a fixing block, the top of the bottom plate is fixedly connected with a mounting plate, the guide plate is fixedly connected to the top of the bottom plate, a trunk limiting mechanism is arranged on one side of the guide plate, and a head limiting mechanism is arranged on the top of the mounting plate. The trunk limiting mechanism and the head limiting mechanism are used for fixing the position of a mouse, the fixing block is fixedly connected to the top of the bottom plate, a vertical plate is fixedly connected to the top of the fixing block, a fixing plate is fixedly connected to the top of the fixing block, a mounting frame is arranged in the fixing plate, a needle tube is arranged in the mounting frame, and a displacement mechanism is arranged on one side of the vertical plate. The utility model aims to solve the problems that the trunk and the head of a rat cannot be stably fixed, so that an injection device cannot be accurately positioned to a target position when the rat is injected, the injection position is inaccurate, and the accuracy of an experimental result is influenced.

Description

Technical Field

[0001] The utility model relates to the technical field of injection devices, in particular to a mouse brain stereotaxic injection device. Background Art

[0002] There are many central nuclei in the central nervous system. Mastering the method of identifying a certain central nucleus is of great significance to studying the occurrence and development mechanism of CNS diseases. Currently, most experiments on the central nervous system are conducted on rat brains. How to quickly and accurately inject drugs into the rat brain has become one of the difficult problems in the current medical community.

[0003] After searching, a Chinese patent discloses a rat brain stereotaxic positioning and adjustment device, and its authorization announcement number is (CN211750141U), which includes a clamping rod, a beam, a push-pull device, a first positioning needle and a second positioning needle. One end of the clamping rod is connected and fixed to the top surface of the beam; the push-pull device is sleeved on the outside of the beam and slides relatively along the beam; the first positioning needle and the second positioning needle are arranged side by side on the bottom surface of the beam, the first positioning needle is fixed to the beam, and the second positioning needle is fixed to the push-pull device. Driven by the push-pull device, the second positioning needle slides relatively with the first positioning needle.

[0004] The device adopts a double-needle positioning measurement form, and the distance between the two needles is adjustable. However, the rat's trunk and head cannot be firmly fixed. This will result in the injection device being unable to accurately locate the target position during the injection of the rat, resulting in inaccurate injection position and affecting the accuracy of the experimental results. Utility Model Content

[0005] In view of the above problems existing in the prior art, the main purpose of the utility model is to provide a mouse brain stereotaxic injection device.

[0006] The technical solution of the utility model is as follows: it includes a base plate, a guide plate and a fixed block, the top of the base plate is fixedly connected with a mounting plate, the guide plate is fixedly connected to the top of the base plate, a torso limiting mechanism is arranged on one side of the guide plate, a head limiting mechanism is arranged on the top of the mounting plate, the torso limiting mechanism and the head limiting mechanism are used to fix the position of the mouse, the fixed block is fixedly connected to the top of the base plate, the top of the fixed block is fixedly connected with a vertical plate, the top of the fixed block is fixedly connected with a fixed plate, a mounting frame is arranged inside the fixed plate, a needle tube is arranged inside the mounting frame, and a displacement mechanism is arranged on one side of the vertical plate.

[0007] As a preferred embodiment, the torso limiting mechanism includes a bidirectional screw rod, which is rotatably connected to one side of the guide plate, and the outer side of the bidirectional screw rod is threadedly connected to two sliders, the tops of the two sliders are fixedly connected to a clamping plate, and one end of the bidirectional screw rod is fixedly connected to a handle.

[0008] As a preferred embodiment, the trunk limiting mechanism further includes a guide rod, the guide rod is slidably connected to the inside of the guide plate, and one end of the guide rod is fixedly connected to one side of the clamping plate.

[0009] As a preferred embodiment, the head limiting mechanism includes a placing plate, which is fixedly connected to the top of the mounting plate, the top of the mounting plate is rotatably connected to a threaded rod, the outer side of the threaded rod is threadedly connected to a displacement plate, and the bottom of the displacement plate is fixedly connected to the limiting plate.

[0010] As a preferred embodiment, the head limiting mechanism further includes a sliding rod, the sliding rod is fixedly connected to the top of the mounting plate, and the outer side of the sliding rod is slidably connected to the inner side of the displacement plate.

[0011] As a preferred embodiment, the displacement mechanism includes a drive motor, which is fixedly mounted on one side of the vertical plate. A reciprocating screw is rotatably connected to one side of the vertical plate, and one end of the reciprocating screw is fixedly connected to one end of an output shaft of the drive motor.

[0012] As a preferred embodiment, the displacement mechanism also includes a displacement block, which is slidably connected to the top of the fixed block, one side of the displacement block is rotationally connected to one end of the reciprocating screw, and one side of the displacement block is in conflict with one end of the needle tube.

[0013] Compared with the prior art, the advantages and positive effects of the utility model are:

[0014] 1. Before injection, place the rat's trunk between the trunk limiting mechanisms, and then rotate the trunk limiting mechanisms to clamp and limit the position of the rat's trunk, thereby preventing it from moving, thereby increasing the practicability of the device.

[0015] 2. Then, by rotating the head limiting mechanism, the head limiting mechanism clamps and limits the rat's head up and down, and further fixes it to avoid the problem of disorderly movement during injection, thereby further increasing the practicality of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 The utility model provides a stereoscopic structural schematic diagram of a mouse brain stereotaxic injection device;

[0017] Figure 2 The utility model provides a side view structural schematic diagram of a mouse brain stereotaxic injection device;

[0018] Figure 3 The utility model provides a schematic diagram of the structure of the trunk limiting mechanism of the mouse brain stereotaxic injection device;

[0019] Figure 4 The utility model provides a schematic diagram of the structure of the head limiting mechanism of a mouse brain stereotaxic injection device.

[0020] Legend: 1. Base plate; 2. Clamping plate; 3. Needle tube; 4. Fixing plate; 5. Drive motor; 6. Mounting plate; 7. Guide plate; 8. Mounting frame; 9. Fixing block; 10. Vertical plate; 11. Threaded rod; 12. Displacement plate; 13. Displacement block; 14. Reciprocating screw; 15. Guide rod; 16. Bidirectional screw; 17. Slider; 18. Handle; 19. Limiting plate; 20. Placement plate; 21. Sliding rod. DETAILED DESCRIPTION

[0021] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0022] Example

[0023] like Figure 1-Figure 4 As shown, the utility model provides a technical solution: it includes a base plate 1, a guide plate 7 and a fixed block 9, the top of the base plate 1 is fixedly connected with a mounting plate 6, the guide plate 7 is fixedly connected to the top of the base plate 1, a torso limiting mechanism is arranged on one side of the guide plate 7, a head limiting mechanism is arranged on the top of the mounting plate 6, the torso limiting mechanism and the head limiting mechanism are used to fix the position of the mouse, the fixed block 9 is fixedly connected to the top of the base plate 1, the top of the fixed block 9 is fixedly connected with a vertical plate 10, the top of the fixed block 9 is fixedly connected with a fixed plate 4, a mounting frame 8 is arranged inside the fixed plate 4, a needle tube 3 is arranged inside the mounting frame 8, and a displacement mechanism is arranged on one side of the vertical plate 10.

[0024] In this embodiment, the torso of the rat is first placed between the torso limiting mechanisms, and then the torso limiting mechanisms are rotated to clamp and limit the position of the torso of the rat, thereby preventing it from moving. Then, the head limiting mechanism is rotated to clamp and limit the head of the rat up and down, thereby further fixing it to prevent it from moving around during injection. Then, the needle tube 3 is installed inside the mounting frame 8, and then placed inside the fixing plate 4, fixed by bolts, and then the displacement mechanism is started to drive the liquid medicine inside the needle tube 3 to be injected into the rat's brain, thereby increasing the practicality of the device.

[0025] Among them, the torso limiting mechanism includes a bidirectional screw rod 16, which is rotatably connected to one side of the guide plate 7. The outer side of the bidirectional screw rod 16 is threadedly connected to two sliders 17. The tops of the two sliders 17 are fixedly connected to the clamping plate 2, and one end of the bidirectional screw rod 16 is fixedly connected to the handle 18.

[0026] The trunk limiting mechanism further includes a guide rod 15, which is slidably connected to the inside of the guide plate 7, and one end of the guide rod 15 is fixedly connected to one side of the clamping plate 2. Before injection, the rat is placed between the two clamping plates 2, and then the handle 18 is turned to drive the two sliders 17 to move outside the bidirectional screw rod 16 and drive the two clamping plates 2 to move relative to each other, clamping and limiting the position of the rat's trunk, and then driving the guide rod 15 to slide inside the guide plate 7 when the two clamping plates 2 move, thereby avoiding the problem of offset when the clamping plates 2 move, and thus better clamping and limiting the rat's trunk.

[0027] Among them, the head limiting mechanism includes a placing plate 20, which is fixedly connected to the top of the mounting plate 6. The top of the mounting plate 6 is rotatably connected to a threaded rod 11, the outer side of the threaded rod 11 is threadedly connected to a displacement plate 12, and the bottom of the displacement plate 12 is fixedly connected to a limiting plate 19.

[0028] The head limiting mechanism further includes a slide bar 21, which is fixedly connected to the top of the mounting plate 6, and the outer side of the slide bar 21 is slidably connected to the inside of the displacement plate 12. When limiting the head of the rat, the head of the rat is placed inside the placement plate 20, and then the threaded rod 11 is rotated to drive the displacement plate 12 to move and drive the limiting plate 19 to limit the top of the rat's head, thereby further increasing the limit of the rat to avoid the problem of disorderly movement. Then, when the displacement plate 12 moves, the limit of the slide bar 21 ensures the moving direction of the displacement plate 12, thereby further increasing the practicality of the device.

[0029] The displacement mechanism includes a drive motor 5 , which is fixedly mounted on one side of a vertical plate 10 , and a reciprocating screw 14 is rotatably connected to one side of the vertical plate 10 , one end of which is fixedly connected to one end of an output shaft of the drive motor 5 .

[0030] The displacement mechanism further includes a displacement block 13, which is slidably connected to the top of the fixed block 9, one side of the displacement block 13 is rotatably connected to one end of the reciprocating screw 14, and one side of the displacement block 13 is in conflict with one end of the needle tube 3. When injecting, the reciprocating screw 14 is driven to rotate by the output shaft of the driving motor 5, and the displacement block 13 is driven to slide on the top of the fixed block 9, and then in conflict with one end of the needle tube 3, so as to drive the liquid medicine inside the needle tube 3 to be injected into the rat's brain, and then the injection operation is completed, thereby increasing the convenience of the device.

[0031] Working principle: First, before injection, place the rat between the two clamping plates 2, then turn the handle 18 to drive the two sliders 17 to move on the outside of the bidirectional screw 16 and drive the two clamping plates 2 to move relative to each other, clamp and limit the position of the rat's trunk, and then drive the guide rod 15 to slide inside the guide plate 7 when the two clamping plates 2 move, thereby avoiding the problem of offset when the clamping plates 2 move, and thus better clamping and limiting the rat's trunk. Next, when limiting the position of the rat's head, place the rat's head inside the placement plate 20, and then rotate the threaded rod 11 to drive the displacement plate 1 2 moves and drives the limiting plate 19 to limit the top of the rat's head, thereby further increasing the limit of the rat to avoid the problem of disorderly movement. Then, when the displacement plate 12 moves, it is limited by the sliding rod 21, thereby ensuring the moving direction of the displacement plate 12, thereby further increasing the practicality of the device. Finally, when injecting, the reciprocating screw rod 14 is driven by the output shaft of the driving motor 5 to rotate and drive the displacement block 13 to slide on the top of the fixed block 9, and then resist one end of the needle tube 3, thereby driving the liquid medicine inside the needle tube 3 to be injected into the rat's brain, and then completing the injection operation, thereby increasing the convenience of the device.

[0032] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A mouse brain stereotaxic injection device, comprising a base plate (1), a guide plate (7) and a fixing block (9), characterized in that: The top of the bottom plate (1) is fixedly connected to a mounting plate (6), the guide plate (7) is fixedly connected to the top of the bottom plate (1), a trunk limiting mechanism is arranged on one side of the guide plate (7), a head limiting mechanism is arranged on the top of the mounting plate (6), the trunk limiting mechanism and the head limiting mechanism are used to fix the position of the mouse, the fixing block (9) is fixedly connected to the top of the bottom plate (1), the top of the fixing block (9) is fixedly connected to a vertical plate (10), the top of the fixing block (9) is fixedly connected to a fixing plate (4), a mounting frame (8) is arranged inside the fixing plate (4), a needle tube (3) is arranged inside the mounting frame (8), and a displacement mechanism is arranged on one side of the vertical plate (10).

2. A mouse brain stereotaxic injection device according to claim 1, characterized in that: The trunk limiting mechanism comprises a bidirectional screw rod (16), the bidirectional screw rod (16) is rotatably connected to one side of the guide plate (7), the outer side of the bidirectional screw rod (16) is threadedly connected to two sliders (17), the tops of the two sliders (17) are fixedly connected to a clamping plate (2), and one end of the bidirectional screw rod (16) is fixedly connected to a handle (18).

3. A mouse brain stereotaxic injection device according to claim 2, characterized in that: The trunk limiting mechanism also includes a guide rod (15), which is slidably connected to the inside of the guide plate (7), and one end of the guide rod (15) is fixedly connected to one side of the clamping plate (2).

4. A mouse brain stereotaxic injection device according to claim 1, characterized in that: The head limiting mechanism comprises a placement plate (20), wherein the placement plate (20) is fixedly connected to the top of the mounting plate (6), the top of the mounting plate (6) is rotatably connected to a threaded rod (11), the outer side of the threaded rod (11) is threadedly connected to a displacement plate (12), and the bottom of the displacement plate (12) is fixedly connected to a limiting plate (19).

5. A mouse brain stereotaxic injection device according to claim 4, characterized in that: The head limiting mechanism further comprises a sliding rod (21), wherein the sliding rod (21) is fixedly connected to the top of the mounting plate (6), and the outer side of the sliding rod (21) is slidably connected to the inside of the displacement plate (12).

6. A mouse brain stereotaxic injection device according to claim 1, characterized in that: The displacement mechanism comprises a drive motor (5), wherein the drive motor (5) is fixedly mounted on one side of a vertical plate (10), and a reciprocating screw rod (14) is rotatably connected to one side of the vertical plate (10), and one end of the reciprocating screw rod (14) is fixedly connected to one end of an output shaft of the drive motor (5).

7. A mouse brain stereotaxic injection device according to claim 6, characterized in that: The displacement mechanism further comprises a displacement block (13), wherein the displacement block (13) is slidably connected to the top of the fixed block (9), one side of the displacement block (13) is rotationally connected to one end of the reciprocating screw rod (14), and one side of the displacement block (13) is in contact with one end of the needle tube (3).

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