Magnetic stirring system

Abstract

The utility model provides a magnetic stirring system which comprises a fixed seat and a magnetic block limiting seat, the bottom of the fixed seat is fixedly connected with the magnetic block limiting seat, a magnetic block is mounted in the magnetic block limiting seat, two O-shaped rings are mounted in the magnetic block limiting seat, and the bottom of the magnetic block limiting seat is fixedly connected with a bearing mounting seat. The non-contact type stirring device has the advantages that the non-contact type stirring mode avoids the leakage problem possibly caused by the fact that a stirring shaft penetrates through a reaction bag in traditional mechanical stirring. Therefore, the magnetic stirring system can ensure the integrity of the reaction bag, effectively prevent leakage of the biological agent and guarantee the safety of the production environment, and can realize rapid and uniform mixing, thereby improving the reaction rate and yield of biological pharmacy. In addition, due to the fact that the risks of leakage and pollution are reduced, the magnetic stirring system is beneficial to reducing the failure rate and downtime in the production process, and the production efficiency is further improved.

Description

Technical Field

[0001] The utility model relates to the technical field of biopharmaceuticals, in particular to a magnetic stirring system. Background Art

[0002] In the biopharmaceutical field, when mechanical stirring is used to stir raw materials, disposable reaction bags are at risk of leakage and contamination. These risks mainly come from the following aspects:

[0003] Physical effect of mechanical stirring: The mechanical stirrer will have a direct physical effect on the reaction bag during the stirring process. This effect may cause the weak parts of the reaction bag (such as the seal or the weak point of the material) to be damaged or torn, resulting in leakage. In addition, the rotation and stirring action of the stirrer may also cause the material in the reaction bag to generate strong vortexes and shear forces, further increasing the risk of leakage.

[0004] Disposable reaction bags are usually made of flexible materials. Although these materials have certain strength and toughness, they may not be able to fully withstand the strong effects of mechanical stirring. Especially when the material of the reaction bag is defective or aged, its resistance to breakage will be further reduced, increasing the possibility of leakage.

[0005] Contamination risk during stirring: During the stirring process, the mechanical stirrer may bring external impurities or microorganisms into the reaction bag, causing contamination.

[0006] Therefore, a new magnetic stirring system is proposed to solve the above problems. Utility Model Content

[0007] The purpose of the present invention is to solve at least one of the above technical deficiencies.

[0008] Therefore, one purpose of the present invention is to provide a magnetic stirring system to solve the problems mentioned in the background technology and overcome the deficiencies in the prior art.

[0009] In order to achieve the above-mentioned purpose, an embodiment of one aspect of the utility model provides a magnetic stirring system, comprising a fixed seat and a magnetic block limiting seat, wherein the bottom of the fixed seat is fixedly connected to the magnetic block limiting seat, a magnetic block is installed inside the magnetic block limiting seat, and two O-rings are installed inside the magnetic block limiting seat;

[0010] The bottom of the magnetic block limit seat is fixedly connected with a bearing mounting seat, a bearing is installed inside the bearing mounting seat, and a bearing pressing piece is installed inside the bearing mounting seat;

[0011] The bearing is movably connected to a stirring shaft, and the end of the stirring shaft is fixedly connected to a magnetic block;

[0012] A shaft sleeve is fixedly connected to the bottom of the bearing mounting seat, and the stirring shaft is movably connected inside the shaft sleeve;

[0013] A limit plate is installed inside the shaft sleeve, and a plurality of groups of stirring paddles are fixedly connected to the outer surface of the stirring shaft;

[0014] The bottom end of the stirring shaft is mounted in another bearing, and the bearing is mounted in the discharge seat.

[0015] Preferably, any of the above schemes is that the magnetic block is fixedly installed in the installation opening of the magnetic block limit seat, and the O-ring is located at the inner edge of the top surface and the outer edge of the bottom surface of the magnetic block.

[0016] Adopting the above technical solution: This system is a stirring system for biopharmaceutical equipment, specifically a magnetic stirring system. This system solves the potential leakage and contamination risks of traditional mechanical stirring applied to disposable reaction bags.

[0017] Preferably, any of the above schemes is that the bearing mounting seat is fastened below the magnetic block limit seat by a barbed hook, and the bearing clamping member is located below the bearing and limits the bearing.

[0018] The above technical solution is adopted: the magnetic block is the magnetic block at the output end, which is magnetically coupled with the magnetic block at the output end of the external motor rotor and rotates synchronously, but there is no mechanical connection, thereby driving the stirring shaft and the stirring paddle to rotate.

[0019] Preferably, any of the above solutions has the interior of the limit plate movably connected to the stirring shaft.

[0020] Adopting the above technical solution: the core structure of this system is: magnetic block limit seat, magnetic block, bearing mounting seat, bearing, stirring shaft, bushing, limit plate, stirring paddle, discharge seat. The core advantages of this system are: the magnetic stirring system adopts the magnetic principle, and drives the internal magnetic block, stirring shaft, and stirring paddle to rotate through the external magnetic field to achieve liquid mixing. This non-contact stirring method avoids the leakage problem that may be caused by the stirring shaft passing through the reaction bag in traditional mechanical stirring. Therefore, the magnetic stirring system can ensure the integrity of the reaction bag, effectively prevent the leakage of biological agents, and ensure the safety of the production environment;

[0021] The magnetic stirring system can achieve fast and uniform mixing, thereby increasing the reaction rate and yield of biopharmaceuticals. In addition, by reducing the risk of leakage and contamination, the magnetic stirring system also helps to reduce the failure rate and downtime in the production process, further improving production efficiency;

[0022] The magnetic stirring system is suitable for disposable reaction bags of different sizes and shapes and has strong adaptability. This enables biopharmaceutical companies to flexibly choose the specifications and quantity of reaction bags according to different production needs and reduce production costs.

[0023] Preferably, any of the above schemes comprises three stirring paddles in a group, and the edges of the stirring paddles are arc-shaped.

[0024] Preferably, in any of the above schemes, two groups of stirring paddles are provided, and a joint is installed at the root of the stirring paddle and the joint is riveted to the stirring shaft.

[0025] Compared with the prior art, the advantages and beneficial effects of the utility model are:

[0026] The magnetic stirring system uses the magnetic principle to drive the internal magnetic block, stirring shaft, and stirring paddle to rotate through the external magnetic field to achieve liquid mixing. This non-contact stirring method avoids the leakage problem that may be caused by the stirring shaft passing through the reaction bag in traditional mechanical stirring. Therefore, the magnetic stirring system can ensure the integrity of the reaction bag, effectively prevent the leakage of biological agents, and ensure the safety of the production environment;

[0027] The magnetic stirring system can achieve fast and uniform mixing, thereby increasing the reaction rate and yield of biopharmaceuticals. In addition, by reducing the risk of leakage and contamination, the magnetic stirring system also helps to reduce the failure rate and downtime in the production process, further improving production efficiency;

[0028] The magnetic stirring system is suitable for disposable reaction bags of different sizes and shapes and has strong adaptability. This enables biopharmaceutical companies to flexibly choose the specifications and quantity of reaction bags according to different production needs and reduce production costs;

[0029] It solves the potential leakage and contamination problems of traditional mechanical stirring applied to disposable reaction bags.

[0030] Additional aspects and advantages of the present invention will be given in part in the following description and in part will become apparent from the following description or will be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0032] Figure 1 It is a structural schematic diagram of the utility model.

[0033] In the figure: 1-fixed seat, 2-magnetic block limit seat, 3-magnetic block, 4-O-ring, 5-bearing mounting seat, 6-bearing, 7-bearing clamping piece, 8-stirring shaft, 9-sleeve, 10-limiting plate, 11-stirring paddle, 12-discharge seat. DETAILED DESCRIPTION

[0034] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and should not be construed as limiting the present invention.

[0035] In the present invention, unless otherwise clearly specified and limited, the terms "install", "connect", "connect", "fix" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0036] like Figure 1 As shown, the magnetic stirring system comprises a fixed seat 1 and a magnetic block limiting seat 2. The bottom of the fixed seat 1 is fixedly connected with the magnetic block limiting seat 2. A magnetic block 3 is installed inside the magnetic block limiting seat 2. Two O-rings 4 are installed inside the magnetic block limiting seat 2.

[0037] The bottom of the magnetic block limit seat 2 is fixedly connected with a bearing mounting seat 5, a bearing 6 is installed inside the bearing mounting seat 5, and a bearing pressing member 7 is installed inside the bearing mounting seat 5;

[0038] The bearing 6 is movably connected to a stirring shaft 8, and the end of the stirring shaft 8 is fixedly connected to the magnetic block 3;

[0039] The bottom of the bearing mounting seat 5 is fixedly connected with a shaft sleeve 9, and the stirring shaft 8 is movably connected inside the shaft sleeve 9;

[0040] A limit plate 10 is installed inside the shaft sleeve 9, and a plurality of stirring paddles 11 are fixedly connected to the outer surface of the stirring shaft 8;

[0041] The bottom end of the stirring shaft 8 is mounted in another bearing 6 , and this bearing 6 is mounted in a discharge seat 12 .

[0042] Embodiment 1: The magnetic block 3 is fixedly mounted in the mounting opening of the magnetic block limit seat 2, and the O-ring 4 is located at the inner edge of the top surface and the outer edge of the bottom surface of the magnetic block 3. This system is a stirring system for biopharmaceutical equipment, specifically a magnetic stirring system, which solves the potential risks of leakage and contamination when traditional mechanical stirring is applied to disposable reaction bags. The bearing mounting seat 5 is fastened to the bottom of the magnetic block limit seat 2 by a barbed hook, and the bearing clamp 7 is located under the bearing 6 and limits the bearing 6. This magnetic block 3 is a magnetic block at the output end, which is magnetically coupled with the magnetic block at the output end of the external motor rotor and rotates synchronously, but there is no mechanical connection, thereby driving the stirring shaft 8 and the stirring paddle 11 to rotate.

[0043] Embodiment 2: The interior of the limit plate 10 is movably connected to the stirring shaft 8. The stirring paddles 11 are arranged in groups of three, and the edges of the stirring paddles 11 are arc-shaped. There are two groups of stirring paddles 11, and the roots of the stirring paddles 11 are equipped with joints which are riveted to the stirring shaft 8.

[0044] The working principle of the utility model is as follows:

[0045] The large magnetic stirring system is usually composed of a motor, a transmission mechanism, a stirring mechanism, and a control unit. The motor drives the transmission mechanism and is magnetically coupled with the magnetic block 3. When the magnetic block 3 rotates, the stirring shaft 8 is driven to rotate in the reaction container. At the same time, the control unit can accurately adjust the stirring speed and stirring time to meet the needs of different biopharmaceutical processes.

[0046] During the stirring process, the rotation of the stirring paddle 11 will drive the reaction liquid to generate forced convection, thereby achieving uniform mixing of the liquid. This mixing effect helps to accelerate the reaction speed and improve production efficiency.

[0047] The O-ring 4 ensures the sealing of the installation of the magnetic block 3 , the bearing pressing piece 7 limits the bearing 6 , the limiting plate 10 limits the stirring shaft 8 and ensures the sealing inside the shaft sleeve 9 .

[0048] Compared with the prior art, the present invention has the following beneficial effects:

[0049] The magnetic stirring system, through the magnetic block limit seat 2, the magnetic block 3, the bearing mounting seat 5, the bearing 6, the stirring shaft 8, the shaft sleeve 9, the limit plate 10, the stirring paddle 11, and the discharge seat 12, adopts the magnetic principle, and drives the internal magnetic block 3, the stirring shaft 8, and the stirring paddle 11 to rotate through the external magnetic field to achieve liquid mixing. This non-contact stirring method avoids the leakage problem that may be caused by the stirring shaft passing through the reaction bag in traditional mechanical stirring. Therefore, the magnetic stirring system can ensure the integrity of the reaction bag, effectively prevent the leakage of biological agents, and ensure the safety of the production environment;

[0050] The magnetic stirring system can achieve fast and uniform mixing, thereby increasing the reaction rate and yield of biopharmaceuticals. In addition, by reducing the risk of leakage and contamination, the magnetic stirring system also helps to reduce the failure rate and downtime in the production process, further improving production efficiency;

[0051] The magnetic stirring system is suitable for disposable reaction bags of different sizes and shapes and has strong adaptability. This enables biopharmaceutical companies to flexibly choose the specifications and quantity of reaction bags according to different production needs and reduce production costs;

[0052] It solves the potential leakage and contamination problems of traditional mechanical stirring applied to disposable reaction bags.

Claims

1. A magnetic stirring system, characterized in that: It comprises a fixed seat (1) and a magnetic block limiting seat (2), wherein the bottom of the fixed seat (1) is fixedly connected to the magnetic block limiting seat (2), a magnetic block (3) is installed inside the magnetic block limiting seat (2), and two O-rings (4) are installed inside the magnetic block limiting seat (2); The bottom of the magnetic block limiting seat (2) is fixedly connected to a bearing mounting seat (5), a bearing (6) is installed inside the bearing mounting seat (5), and a bearing pressing member (7) is installed inside the bearing mounting seat (5); The bearing (6) is movably connected to a stirring shaft (8), and the end of the stirring shaft (8) is fixedly connected to the magnetic block (3); the bottom of the bearing mounting seat (5) is fixedly connected to a shaft sleeve (9), and the stirring shaft (8) is movably connected to the inside of the shaft sleeve (9); A limit plate (10) is installed inside the shaft sleeve (9), and a plurality of groups of stirring paddles (11) are fixedly connected to the outer surface of the stirring shaft (8); The bottom end of the stirring shaft (8) is mounted in another bearing (6), and the bearing (6) is mounted in a discharge seat (12).

2. A magnetic stirring system as claimed in claim 1, characterized in that: The magnetic block (3) is fixedly mounted in the mounting opening of the magnetic block limiting seat (2), and the O-ring (4) is located at the inner edge of the top surface and the outer edge of the bottom surface of the magnetic block (3).

3. A magnetic stirring system as claimed in claim 2, characterized in that: The bearing mounting seat (5) is fastened below the magnetic block limiting seat (2) via a barbed hook, and the bearing pressing member (7) is located below the bearing (6) and limits the bearing (6).

4. A magnetic stirring system as claimed in claim 3, characterized in that: The interior of the limiting plate (10) is movably connected to the stirring shaft (8).

5. A magnetic stirring system as claimed in claim 4, characterized in that: The stirring paddles (11) are grouped in three pieces, and the edges of the stirring paddles (11) are arc-shaped.

6. A magnetic stirring system as claimed in claim 5, characterized in that: Two groups of stirring paddles (11) are provided in total. A joint is installed at the root of each stirring paddle (11) and the joint is riveted to the stirring shaft (8).

Images