Centrifugal tube device for observing sedimentation of magnetic beads

Abstract

The utility model discloses a centrifugal tube device for observing sedimentation of magnetic beads. The centrifugal tube device comprises an observation box (1) and four groups of leveling knobs (16), wherein the observation box (1) is provided with a plurality of groups of centrifugal tube holes (111); and the four groups of leveling knobs (16) are uniformly arranged at the bottom of the observation box (1). According to the centrifugal tube device for observing the sedimentation of the magnetic beads, disclosed by the utility model, the level of the observation box (1) can be adjusted by rotating the leveling knob (16), so that the centrifugal tube (14) can be ensured to be in a vertical state.

Description

Technical Field

[0001] The utility model belongs to the technical field of magnetic bead separation, in particular to a centrifuge tube device for observing the sedimentation of magnetic beads. Background Art

[0002] The sedimentation rate of biological magnetic beads is an important indicator to measure the performance of biological magnetic beads. The slower the sedimentation rate, the better the uniformity of the sample addition and the better the operating experience. At present, the sedimentation rate of magnetic beads is mainly measured in 2ml centrifuge tubes. First, add 2ml of magnetic beads to the 2ml centrifuge tube, shake it manually, and place the centrifuge tube upright. When it settles to the 1ml mark, record the sedimentation time.

[0003] Generally, a centrifuge tube is kept upright by inserting it into a foam floating board and placing it on a flat surface. However, due to the poor stability of the foam floating board, the centrifuge tube cannot be completely kept in a vertical state. Utility Model Content

[0004] The utility model aims to provide a centrifuge tube device for observing the sedimentation of magnetic beads.

[0005] The utility model provides a centrifuge tube device for observing the sedimentation of magnetic beads, comprising an observation box (1) provided with a plurality of groups of centrifuge tube holes (111) and four groups of leveling knobs (16); the four groups of leveling knobs (16) are evenly arranged at the bottom of the observation box (1).

[0006] Preferably, the observation box (1) is enclosed by an upper panel (11), a left panel (17), a right panel (13), a front panel, a rear panel (19) and a bottom panel (18); a plurality of groups of centrifuge tube holes (111) are evenly arranged on the upper panel (11); a first fixing groove (12) is also provided at the center of the upper panel (11); a level bubble is fixed in the first fixing groove (12).

[0007] Preferably, the outer wall of the leveling knob (16) is provided with an external thread (161); the four top corners of the bottom panel (18) are provided with adjustment holes; and the adjustment holes are provided with internal threads matching the external thread (161).

[0008] Preferably, the front panel, the bottom panel (18) and the upper panel (11) are all transparent acrylic panels; and scale lines are provided on the front panel.

[0009] Preferably, the rear panel (19) is a soft light panel, and a power slot (151) is provided on the rear panel (19).

[0010] Preferably, the left side panel (17) and the right side panel (13) both have a hollow structure.

[0011] Preferably, the inner surface of the bottom panel (18) is provided with centrifuge tube grooves (181) corresponding one-to-one to the centrifuge tube holes (111).

[0012] Preferably, the centrifuge tube device for observing the sedimentation of magnetic beads provided by the utility model further comprises a fixing component (2), a connecting shaft (24) and a motor (23); the two ends of the connecting shaft (24) are respectively connected to the fixing component (2) and the motor (23); and the observation box (1) is fixed in the fixing component (2).

[0013] Preferably, the fixing assembly (2) comprises an upper cover plate (25), a lower base plate (26) and a connecting plate (27); one end of the connecting plate (27) is hinged to one end of the upper cover plate (25), and the other end is fixed to one end of the lower base plate (26); the other ends of the upper cover plate (25) and the lower base plate (26) are movably connected; and the observation box (1) is arranged between the upper cover plate (25) and the lower base plate (26).

[0014] Preferably, one end of the lower base plate (26) away from the connecting plate (27) is movably connected with a buckle (21); and one end of the upper cover plate (25) away from the connecting plate (27) is provided with a protrusion (254) matching the buckle (21).

[0015] Preferably, the upper cover plate (25) and the lower base plate (26) both comprise a first plate body (251), a second plate body (252) and a third plate body (253); the first plate body (251), the second plate body (252) and the third plate body (253) are sequentially connected to form a C-shaped structure.

[0016] The centrifuge tube device for observing magnetic bead sedimentation provided by the utility model has the following advantages compared with the prior art:

[0017] 1. When observing the sedimentation of magnetic beads, the fixed components can be used for mixing, eliminating the reliance on manual shaking;

[0018] 2. By observing the level bubble and adjusting the 4 leveling knobs, it can be ensured that the settlement is carried out under horizontal conditions, ensuring the accuracy of the measurement;

[0019] 3. After lighting up the soft light on the rear surface, the interface of the magnetic beads in the centrifuge tube can be observed more clearly;

[0020] 4. The scale on the front panel can be used to compare the sedimentation speed of different magnetic beads. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 A schematic diagram of the structure of a centrifuge tube device for observing the sedimentation of magnetic beads provided by the utility model;

[0022] Figure 2 A schematic diagram of the structure of the fixed assembly, the connecting shaft and the motor provided in the embodiment of the utility model;

[0023] Figure 3 A schematic diagram of the structure of the observation box provided by the embodiment of the utility model;

[0024] Figure 4 for Figure 3 A schematic cross-sectional structure diagram of ;

[0025] Figure 5 A schematic diagram of the structure of the upper cover provided by an embodiment of the utility model;

[0026] Figure 6 A schematic diagram of the structure of a leveling knob provided by an embodiment of the utility model;

[0027] Figure 7 A schematic diagram of the structure of the lower base plate and the connecting plate provided in an embodiment of the utility model. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all of the embodiments. Based on the embodiment of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0029] like Figure 1-Figure 7 As shown, the centrifuge tube device for observing the sedimentation of magnetic beads provided in this embodiment includes an observation box 1 provided with multiple groups of centrifuge tube holes 111 and four groups of leveling knobs 16; the four groups of leveling knobs 16 are evenly arranged at the bottom of the observation box 1. Those skilled in the art can understand that by rotating the leveling knobs 16, the level of the observation box 1 can be adjusted, so as to ensure that the centrifuge tube 14 is in a vertical state.

[0030] Furthermore, the observation box 1 is enclosed by an upper panel 11, a left side panel 17, a right panel 13, a front panel (not shown in the figure), a rear panel 19 and a bottom panel 18; a plurality of groups of centrifuge tube holes 111 are evenly arranged on the upper panel 11; a first fixing groove 12 is also provided at the center of the upper panel 11; a level bubble (not shown in the figure) is fixed in the first fixing groove 12. Those skilled in the art will understand that by inserting the centrifuge tube 14 into the centrifuge tube hole 111, it is fixed in the observation box 1, and by observing the position of the level bubble, it is convenient for the experimenter to adjust the level of the observation box 1. The level bubble is a prior art and will not be described in detail here.

[0031] Furthermore, the outer wall of the leveling knob 16 is provided with an external thread 161 ; the four top corners of the bottom panel 18 are provided with adjustment holes (not shown in the figure); the adjustment holes are provided with internal threads (not shown in the figure) matching the external threads 161 .

[0032] Furthermore, the front panel, the bottom panel 18 and the upper panel 11 are all transparent acrylic panels; the front panel is provided with scale lines (not shown in the figure). Those skilled in the art will appreciate that this facilitates the experimenter to check the sedimentation state and sedimentation speed of the magnetic beads in the centrifuge tube 14.

[0033] Further, the rear panel 19 is a soft light panel, and a power slot 151 is provided on the rear panel 19. Those skilled in the art will understand that the soft light panel is a prior art and will not be described in detail here. The power slot 151 can be an interface for connecting a USB, which is used to light a soft light and observe the sedimentation speed of the magnetic beads in the centrifuge tube 14.

[0034] Further, the left side panel 17 and the right side panel 13 both have a hollow structure. Those skilled in the art will appreciate that the hollow structure (not shown in the figure) can increase the light transmittance of the observation box 1, thereby facilitating observation of the centrifuge tube 14.

[0035] Furthermore, the inner surface of the bottom panel 18 is provided with centrifuge tube grooves 181 corresponding to the centrifuge tube holes 111. Those skilled in the art will appreciate that the centrifuge tube 14 is fixed by the centrifuge tube grooves 181 to prevent the centrifuge tube 14 from shaking in the observation box 1.

[0036] Furthermore, the centrifuge tube device for observing the sedimentation of magnetic beads provided in this embodiment also includes a fixing component 2, a connecting shaft 24 and a motor 23; the two ends of the connecting shaft 24 are respectively connected to the fixing component 2 and the motor 23; the observation box 1 is fixed in the fixing component 2. Those skilled in the art can understand that the rotation of the motor 23 drives the fixing component 2 to rotate, and then drives the observation box 1 to rotate, and finally mixes the biological magnetic beads in the centrifuge tube 14. The motor 23 is powered by a 220V AC power supply.

[0037] Furthermore, the fixing assembly 2 includes an upper cover plate 25, a lower base plate 26 and a connecting plate 27; one end of the connecting plate 27 is hinged to one end of the upper cover plate 25, and the other end is fixed to one end of the lower base plate 26; the other ends of the upper cover plate 25 and the lower base plate 26 are movably connected; the observation box 1 is arranged between the upper cover plate 25 and the lower base plate 26.

[0038] Furthermore, one end of the lower base plate 26 away from the connecting plate 27 is movably connected with a buckle 21 ; and one end of the upper cover plate 25 away from the connecting plate 27 is provided with a protrusion 254 matching with the buckle 21 .

[0039] Furthermore, the upper cover plate 25 and the lower bottom plate 26 each include a first plate 251, a second plate 252 and a third plate 253; the first plate 251, the second plate 252 and the third plate 253 are sequentially connected to form a C-shaped structure. It can be understood by those skilled in the art that the observation box 1 can be restricted between the upper cover plate 25 and the lower bottom plate 26 by the first plate 251 and the third plate 253 to prevent the observation box 1 from slipping during the rotation process.

[0040] Principle: When in use, put the centrifuge tube 14 containing magnetic beads into the observation box 1, then put the entire observation box 1 between the upper cover plate 25 and the lower base plate 26 of the fixed component 2, fasten the buckle 21, turn on the motor 23 to rotate and shake the biological magnetic beads evenly; after shaking evenly, open the buckle 21 to take out the observation box 1, first adjust the four leveling knobs 16 to make the level bubble in the center circle, connect the USB interface, light up the soft light board, and observe the sedimentation speed of the magnetic beads in the centrifuge tube 14.

[0041] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the utility model, rather than to limit it. Although the utility model has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the utility model.

Claims

1. A centrifuge tube device for observing magnetic bead sedimentation, characterized in that: It comprises an observation box (1) provided with a plurality of groups of centrifuge tube holes (111) and four groups of leveling knobs (16); the four groups of leveling knobs (16) are evenly arranged at the bottom of the observation box (1); The observation box (1) is formed by enclosing an upper panel (11), a left panel (17), a right panel (13), a front panel, a rear panel (19) and a bottom panel (18); a plurality of groups of centrifuge tube holes (111) are evenly arranged on the upper panel (11); a first fixing groove (12) is also provided at the center of the upper panel (11); a level bubble is fixed in the first fixing groove (12).

2. The centrifuge tube device for observing magnetic bead sedimentation according to claim 1, characterized in that: The outer wall of the leveling knob (16) is provided with an external thread (161); the four top corners of the bottom panel (18) are each provided with an adjustment hole; and the adjustment hole is provided with an internal thread matching the external thread (161).

3. The centrifuge tube device for observing magnetic bead sedimentation as claimed in claim 2, characterized in that: The front panel, the bottom panel (18) and the upper panel (11) are all transparent acrylic panels; and scale lines are provided on the front panel.

4. The centrifuge tube device for observing magnetic bead sedimentation as claimed in claim 3, characterized in that: The rear panel (19) is a soft light panel, and a power slot (151) is provided on the rear panel (19); The left side panel (17) and the right side panel (13) both have a hollow structure.

5. The centrifuge tube device for observing magnetic bead sedimentation according to claim 4, characterized in that: The inner surface of the bottom panel (18) is provided with centrifuge tube grooves (181) corresponding one-to-one to the centrifuge tube holes (111).

6. The centrifuge tube device for observing magnetic bead sedimentation according to claim 5, characterized in that: It also comprises a fixing component (2), a connecting shaft (24) and a motor (23); the two ends of the connecting shaft (24) are respectively connected to the fixing component (2) and the motor (23); and the observation box (1) is fixed in the fixing component (2).

7. The centrifuge tube device for observing magnetic bead sedimentation according to claim 6, characterized in that: The fixing assembly (2) comprises an upper cover plate (25), a lower base plate (26) and a connecting plate (27); one end of the connecting plate (27) is hinged to one end of the upper cover plate (25), and the other end is fixed to one end of the lower base plate (26); the other ends of the upper cover plate (25) and the lower base plate (26) are movably connected; and the observation box (1) is arranged between the upper cover plate (25) and the lower base plate (26).

8. The centrifuge tube device for observing magnetic bead sedimentation according to claim 7, characterized in that: One end of the lower base plate (26) away from the connecting plate (27) is movably connected with a buckle (21); and one end of the upper cover plate (25) away from the connecting plate (27) is provided with a protrusion (254) matching the buckle (21).

9. The centrifuge tube device for observing magnetic bead sedimentation according to claim 8, characterized in that: The upper cover plate (25) and the lower base plate (26) both comprise a first plate body (251), a second plate body (252) and a third plate body (253); the first plate body (251), the second plate body (252) and the third plate body (253) are sequentially connected to form a C-shaped structure.

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