High-pressure reaction kettle for preparing benpipralin phosphate

Abstract

The utility model relates to the technical field of benpipralin phosphate preparation, in particular to a high-pressure reaction kettle for benpipralin phosphate preparation, which is characterized in that when the high-pressure reaction kettle is used, various raw materials for producing benpipralin phosphate enter a cavity through a feeding pipe, a valve is closed, and then a stirring assembly is started; the stirring assembly is used for stirring various raw materials in the chamber in multiple directions, so that the various raw materials are quickly and uniformly mixed, and the cooling assembly is used for cooling the reaction raw materials in the chamber due to heat release operation in the production process of benpipralin phosphate; comprising a reaction kettle body, a safety valve and a feeding pipe, the feeding pipe is arranged at the input end of the reaction kettle body, the safety valve is arranged at the top end of the reaction kettle body, the reaction kettle further comprises a cooling assembly and a stirring assembly, a cavity is formed in the reaction kettle body, and the stirring assembly is installed in the cavity and used for mixing and stirring raw materials in the cavity in multiple directions. The outer side of the reaction kettle body is sleeved with a cooling assembly, and a valve is mounted on the feeding pipe.

Description

Technical Field

[0001] The utility model relates to the technical field of preparation of benproperine phosphate, in particular to a high-pressure reaction kettle for preparation of benproperine phosphate. Background Art

[0002] Benproperine phosphate is a powerful antitussive drug, mainly used to treat acute and chronic bronchitis and cough. In the pharmaceutical industry, the preparation of benproperine phosphate requires strict control of parameters such as temperature, pressure and reaction time to ensure product quality and safety. The use of high-pressure reactors can accurately control these parameters to obtain high-quality products.

[0003] In the prior art, a patent document with announcement number CN220126147U discloses a high-pressure reactor for drug experimental reactions, including a reaction tank, a sealing cover, a protective structure and a stirring and cleaning structure. The sealing cover is fixedly connected above the reaction tank, the protective structure is wrapped around the outside of the reaction tank, and the stirring and cleaning structure is fixedly connected inside the reaction tank.

[0004] When the above device is used, the stirring method is relatively simple, resulting in poor uniformity of raw material mixing, which further affects the reaction quality. Utility Model Content

[0005] In order to solve the above technical problems, the utility model provides a high-pressure reactor for preparing benproperine phosphate with improved reaction efficiency.

[0006] The utility model discloses a high-pressure reactor for preparing benproperine phosphate, comprising a reactor body, a safety valve and a feed pipe, wherein the feed pipe is arranged at the input end of the reactor body, the safety valve is arranged at the top of the reactor body, the reactor body further comprises a cooling component and a stirring component, a chamber is arranged inside the reactor body, a stirring component is installed in the chamber, the stirring component is used for mixing and stirring raw materials in the chamber in multiple directions, the cooling component is sleeved on the outer side of the reactor body, and a valve is installed on the feed pipe; when in use, multiple raw materials for producing benproperine phosphate are introduced into the chamber through the feed pipe and the valve is closed, then the stirring component is started, and the stirring component stirs the multiple raw materials in the chamber in multiple directions, so that the multiple raw materials are quickly and evenly mixed, and since the production process of benproperine phosphate is an exothermic operation, the reaction raw materials in the chamber are cooled and cooled by the cooling component, so as to improve the reaction efficiency and reaction quality.

[0007] Preferably, the stirring assembly includes a motor, a rotating shaft, a stirring blade No. 1, an L-shaped support rod and a spiral blade. A motor is arranged at the top of the reactor body, and the output end of the motor extends into the chamber and is connected to the top of the rotating shaft. Multiple groups of stirring blades No. 1 are symmetrically arranged on the outer wall of the rotating shaft, and the multiple groups of stirring blades No. 1 are respectively arranged at an angle to the horizontal plane. Two groups of L-shaped support rods are symmetrically arranged at the bottom end of the rotating shaft, and two groups of spiral blades are arranged between the two groups of L-shaped support rods, and the rotating shaft and the multiple groups of stirring blades No. 1 are between the two groups of spiral blades. Start the motor, so that the rotating shaft drives the multiple groups of stirring blades No. 1 to rotate, and the multiple groups of stirring blades No. 1 mix and stir the raw materials. At the same time, the rotating shaft synchronously drives the two groups of L-shaped support rods to rotate, and the spiral shape of the two groups of spiral blades is utilized to further stir the raw materials, thereby improving the stirring efficiency.

[0008] Preferably, the cooling assembly includes a water jacket, a water inlet pipe, a water outlet pipe, a No. 1 thermometer and a No. 2 thermometer. The outer side wall of the reactor body is covered with a water jacket, the water jacket input end is provided with a water inlet pipe, the water jacket output end is provided with a water outlet pipe, the water inlet pipe is installed with a No. 1 thermometer, the water outlet pipe is installed with a No. 2 thermometer, and the height of the water outlet pipe is higher than that of the water inlet pipe. When the chamber needs to be cooled, cooling water enters the water jacket through the water inlet pipe, the cooling water entering the water jacket cools the chamber through heat transfer, and the cooling water that absorbs heat is discharged through the water outlet pipe. The No. 1 thermometer detects the inlet temperature of the cooling water, and the No. 2 thermometer detects the outlet temperature of the cooling water, which is convenient for observation by the staff.

[0009] Preferably, the stirring assembly includes a fixed rod and No. 2 stirring blades, the top ends of the two groups of fixed rods are connected to the top end of the chamber, and multiple groups of No. 2 stirring blades are respectively arranged on the opposite outer sides of the two groups of fixed rods, and the multiple groups of No. 2 stirring blades are cross-matched with the multiple groups of No. 1 stirring blades, respectively, and the rotating shaft is between the two groups of fixed rods, and the two groups of fixed rods are between the two groups of L-shaped support rods and the two groups of spiral blades; when the rotating shaft drives the multiple groups of No. 1 stirring blades, the two groups of L-shaped support rods and the two groups of spiral blades to rotate, the fixed rods and the multiple groups of No. 2 stirring blades are fixed, so that the multiple groups of rotating shafts and the multiple groups of No. 2 stirring blades produce relative movement in opposite directions, thereby further realizing the mixing and stirring of the raw materials.

[0010] Preferably, it also includes legs and supports. The bottom of the reactor body is provided with multiple groups of legs, and the bottom of each group of legs is provided with a support. The multiple groups of legs and the multiple groups of supports cooperate with each other to stably support the reactor body, thereby improving stability.

[0011] Preferably, it also includes a manhole, a manhole cover and a handle. A manhole is arranged at the rear end of the reactor body, a manhole cover is arranged at the rear end of the manhole, and a handle is installed at the rear end of the manhole cover. When it is necessary to perform internal inspection on the reactor body, the staff separates the manhole cover from the manhole and moves the manhole cover by the handle to improve convenience.

[0012] Preferably, it also includes a reinforcing plate, and a plurality of groups of reinforcing plates are arranged between the legs and the support; the legs and the support are reinforced and connected by the reinforcing plates to improve the firmness of the connection.

[0013] Compared with the prior art, the utility model has the following beneficial effects: when in use, various raw materials for producing benproperine phosphate are introduced into the chamber through the feed pipe and the valve is closed, and then the stirring component is started, and the stirring component stirs the various raw materials in the chamber in multiple directions, so that the various raw materials are quickly mixed and evenly mixed; since the production process of benproperine phosphate is an exothermic operation, the reaction raw materials in the chamber are cooled and lowered by the cooling component, thereby improving the reaction efficiency and reaction quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a first axonometric structural schematic diagram of the utility model;

[0015] Figure 2 It is a second axonometric structural schematic diagram of the utility model;

[0016] Figure 3 It is an enlarged structural schematic diagram of the reactor body and the rotating shaft;

[0017] Figure 4 It is an enlarged structural diagram of structures such as a fixed rod and a spiral blade;

[0018] Figure 5 It is an enlarged structural schematic diagram of structures such as the water jacket and the water inlet pipe.

[0019] Markings in the attached figure: 1. Reactor body; 3. Safety valve; 4. Feed pipe; 5. Motor; 6. Rotating shaft; 7. Stirring blade No. 1; 8. L-shaped support rod; 9. Spiral blade; 10. Water jacket; 11. Water inlet pipe; 12. Water outlet pipe; 13. Thermometer No. 1; 14. Thermometer No. 2; 15. Fixed rod; 16. Stirring blade No. 2; 17. Support leg; 18. Support; 19. Manhole; 20. Manhole cover; 21. Handle; 22. Reinforcement plate. DETAILED DESCRIPTION

[0020] In order to facilitate the understanding of the utility model, the utility model will be described more comprehensively below with reference to the relevant drawings. The utility model can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the utility model more thorough and comprehensive.

[0021] Example 1

[0022] like Figure 1 , Figure 2 and Figure 3As shown, a high-pressure reactor for preparing benproperine phosphate of the utility model comprises a reactor body 1, a safety valve 3 and a feed pipe 4, wherein the feed pipe 4 is arranged at the input end of the reactor body 1, the safety valve 3 is arranged at the top of the reactor body 1, and further comprises a cooling component and a stirring component, wherein a chamber is arranged inside the reactor body 1, and a stirring component is installed in the chamber, and the stirring component is used to mix and stir the raw materials in the chamber in various directions, a cooling component is arranged outside the reactor body 1, and a valve is installed on the feed pipe 4;

[0023] like Figure 3 and Figure 4 As shown, the stirring assembly includes a motor 5, a rotating shaft 6, a stirring blade 7, an L-shaped support rod 8 and a spiral blade 9. The motor 5 is arranged at the top of the reactor body 1, and the output end of the motor 5 extends into the chamber and is connected to the top of the rotating shaft 6. A plurality of groups of stirring blades 7 are symmetrically arranged on the outer wall of the rotating shaft 6, and the plurality of groups of stirring blades 7 are respectively arranged at an angle with the horizontal plane. Two groups of L-shaped support rods 8 are symmetrically arranged at the bottom end of the rotating shaft 6, and two groups of spiral blades 9 are arranged between the two groups of L-shaped support rods 8. The rotating shaft 6 and the plurality of groups of stirring blades 7 are between the two groups of spiral blades 9.

[0024] like Figure 3 and Figure 4 As shown, the stirring assembly includes a fixed rod 15 and a No. 2 stirring blade 16. The top ends of the two groups of fixed rods 15 are connected to the top end of the chamber. The two groups of fixed rods 15 are respectively provided with multiple groups of No. 2 stirring blades 16 on the outer side walls relative to each other. The multiple groups of No. 2 stirring blades 16 are cross-matched with the multiple groups of No. 1 stirring blades 7 respectively. The rotating shaft 6 is between the two groups of fixed rods 15, and the two groups of fixed rods 15 are between the two groups of L-shaped support rods 8 and the two groups of spiral blades 9.

[0025] In this embodiment, when in use, a variety of raw materials for producing benproperine phosphate are introduced into the chamber through the feed pipe 4 and the valve is closed, and the motor 5 is started, so that the rotating shaft 6 drives the multiple groups of No. 1 stirring blades 7 to rotate, and the multiple groups of No. 1 stirring blades 7 mix and stir the raw materials. At the same time, the rotating shaft 6 synchronously drives the two groups of L-shaped support rods 8 to rotate, and the spiral shape of the two groups of spiral blades 9 is used to further stir the raw materials. When the rotating shaft 6 drives the multiple groups of No. 1 stirring blades 7, the two groups of L-shaped support rods 8 and the two groups of spiral blades 9 to rotate, the fixed rod 15 and the multiple groups of No. 2 stirring blades 16 are fixed, so that the multiple groups of rotating shafts 6 and the multiple groups of No. 2 stirring blades 16 produce relative movement in opposite directions, further realizing the mixing and stirring of the raw materials, and the reaction raw materials in the chamber are cooled and cooled by the cooling component.

[0026] Example 2

[0027] like Figure 1 , Figure 2 and Figure 3As shown, a high-pressure reactor for preparing benproperine phosphate of the utility model comprises a reactor body 1, a safety valve 3 and a feed pipe 4, wherein the feed pipe 4 is arranged at the input end of the reactor body 1, the safety valve 3 is arranged at the top of the reactor body 1, and further comprises a cooling component and a stirring component, wherein a chamber is arranged inside the reactor body 1, and a stirring component is installed in the chamber, and the stirring component is used to mix and stir the raw materials in the chamber in various directions, a cooling component is arranged outside the reactor body 1, and a valve is installed on the feed pipe 4;

[0028] like Figure 3 and Figure 4 As shown, the stirring assembly includes a motor 5, a rotating shaft 6, a stirring blade 7, an L-shaped support rod 8 and a spiral blade 9. The motor 5 is arranged at the top of the reactor body 1, and the output end of the motor 5 extends into the chamber and is connected to the top of the rotating shaft 6. A plurality of groups of stirring blades 7 are symmetrically arranged on the outer wall of the rotating shaft 6, and the plurality of groups of stirring blades 7 are respectively arranged at an angle with the horizontal plane. Two groups of L-shaped support rods 8 are symmetrically arranged at the bottom end of the rotating shaft 6, and two groups of spiral blades 9 are arranged between the two groups of L-shaped support rods 8. The rotating shaft 6 and the plurality of groups of stirring blades 7 are between the two groups of spiral blades 9.

[0029] like Figure 3 and Figure 4 As shown, the stirring assembly includes a fixed rod 15 and a second stirring blade 16. The top ends of the two groups of fixed rods 15 are connected to the top end of the chamber. The two groups of fixed rods 15 are respectively provided with multiple groups of second stirring blades 16 on the outer side walls opposite to each other. The multiple groups of second stirring blades 16 are respectively cross-matched with the multiple groups of first stirring blades 7. The rotating shaft 6 is between the two groups of fixed rods 15. The two groups of fixed rods 15 are between the two groups of L-shaped support rods 8 and the two groups of spiral blades 9.

[0030] like Figure 5 As shown, the cooling assembly includes a water jacket 10, a water inlet pipe 11, a water outlet pipe 12, a first thermometer 13 and a second thermometer 14. The outer wall of the reactor body 1 is provided with a water jacket 10, the input end of the water jacket 10 is provided with a water inlet pipe 11, the output end of the water jacket 10 is provided with a water outlet pipe 12, the first thermometer 13 is installed on the water inlet pipe 11, the second thermometer 14 is installed on the water outlet pipe 12, and the height of the water outlet pipe 12 is higher than the height of the water inlet pipe 11;

[0031] like Figure 1 As shown, it also includes legs 17 and a support 18. The bottom of the reactor body 1 is provided with multiple groups of legs 17, and the bottom of each group of legs 17 is provided with a support 18;

[0032] like Figure 2 As shown, it also includes a manhole 19, a manhole cover 20 and a handle 21. The rear end of the reactor body 1 is provided with a manhole 19, the rear end of the manhole 19 is provided with a manhole cover 20, and the rear end of the manhole cover 20 is installed with a handle 21;

[0033] like Figure 1 As shown, reinforcing plates 22 are also included, and multiple groups of reinforcing plates 22 are arranged between the supporting legs 17 and the support 18.

[0034] In this embodiment, when in use, a variety of raw materials for producing benproperine phosphate are introduced into the chamber through the feed pipe 4 and the valve is closed, and the motor 5 is started, so that the rotating shaft 6 drives the multiple groups of No. 1 stirring blades 7 to rotate, and the multiple groups of No. 1 stirring blades 7 mix and stir the raw materials. At the same time, the rotating shaft 6 synchronously drives the two groups of L-shaped support rods 8 to rotate, and the spiral shape of the two groups of spiral blades 9 is used to further stir the raw materials. When the rotating shaft 6 drives the multiple groups of No. 1 stirring blades 7, the two groups of L-shaped support rods 8 and the two groups of spiral blades 9 to rotate, the fixed rod 15 and the multiple groups of No. 2 stirring blades 7 are rotated. The first stirring blade 16 is fixed, so that the multiple groups of rotating shafts 6 and the multiple groups of second stirring blades 16 produce relative movement in opposite directions, further realizing the mixing and stirring of the raw materials. When the chamber needs to be cooled, cooling water enters the water jacket 10 through the water inlet pipe 11, and the cooling water entering the water jacket 10 cools the chamber through heat transfer. The cooling water that absorbs heat is discharged through the water outlet pipe 12. Thermometer No. 1 13 detects the inlet temperature of the cooling water, and thermometer No. 2 14 detects the outlet temperature of the cooling water, which is convenient for staff to observe.

[0035] The reactor body 1 and the motor 5 of the high-pressure reactor for preparing benproperine phosphate of the utility model are purchased on the market, and technicians in the industry only need to install and operate them according to the accompanying instruction manual, without the need for creative labor by technicians in the field.

[0036] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the technical principle of the present invention. These improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A high-pressure reactor for preparing benproperine phosphate, comprising a reactor body (1), a safety valve (3) and a feed pipe (4), wherein the feed pipe (4) is arranged at the input end of the reactor body (1), and the safety valve (3) is arranged at the top of the reactor body (1), characterized in that: It also includes a cooling component and a stirring component. A chamber is provided inside the reactor body (1), and a stirring component is installed in the chamber. The stirring component is used to mix and stir the raw materials in the chamber in multiple directions. The cooling component is mounted on the outside of the reactor body (1), and a valve is installed on the feed pipe (4).

2. A high-pressure reactor for preparing benproperine phosphate as claimed in claim 1, characterized in that: The stirring assembly comprises a motor (5), a rotating shaft (6), a stirring blade (7), an L-shaped support rod (8) and a spiral blade (9). The motor (5) is arranged at the top of the reactor body (1). The output end of the motor (5) extends into the chamber and is connected to the top of the rotating shaft (6). A plurality of groups of stirring blades (7) are symmetrically arranged on the outer wall of the rotating shaft (6). The plurality of groups of stirring blades (7) are arranged at an angle to the horizontal plane. Two groups of L-shaped support rods (8) are symmetrically arranged at the bottom end of the rotating shaft (6). Two groups of spiral blades (9) are arranged between the two groups of L-shaped support rods (8). The rotating shaft (6) and the plurality of groups of stirring blades (7) are between the two groups of spiral blades (9).

3. A high-pressure reactor for preparing benproperine phosphate as claimed in claim 1, characterized in that: The cooling assembly comprises a water jacket (10), a water inlet pipe (11), a water outlet pipe (12), a first thermometer (13) and a second thermometer (14); the outer wall of the reactor body (1) is provided with the water jacket (10); the input end of the water jacket (10) is provided with the water inlet pipe (11); the output end of the water jacket (10) is provided with the water outlet pipe (12); the first thermometer (13) is installed on the water inlet pipe (11); the second thermometer (14) is installed on the water outlet pipe (12); and the height of the water outlet pipe (12) is higher than the height of the water inlet pipe (11).

4. A high-pressure reactor for preparing benproperine phosphate as claimed in claim 2, characterized in that: The stirring assembly comprises a fixed rod (15) and a second stirring blade (16), the top ends of the two groups of fixed rods (15) are connected to the top end of the chamber, a plurality of groups of second stirring blades (16) are respectively arranged on the outer side walls opposite to the two groups of fixed rods (15), the plurality of groups of second stirring blades (16) are respectively cross-matched with the plurality of groups of first stirring blades (7), the rotating shaft (6) is between the two groups of fixed rods (15), and the two groups of fixed rods (15) are between the two groups of L-shaped support rods (8) and the two groups of spiral blades (9).

5. A high-pressure reactor for preparing benproperine phosphate as claimed in claim 1, characterized in that: It also comprises legs (17) and a support (18); a plurality of groups of legs (17) are arranged at the bottom end of the reactor body (1), and a support (18) is arranged at the bottom end of each group of legs (17).

6. A high-pressure reactor for preparing benproperine phosphate as claimed in claim 1, characterized in that: The reactor body (1) further comprises a manhole (19), a manhole cover (20) and a handle (21). The rear end of the reactor body (1) is provided with the manhole (19), the rear end of the manhole (19) is provided with the manhole cover (20), and the rear end of the manhole cover (20) is provided with the handle (21).

7. A high-pressure reactor for preparing benproperine phosphate as claimed in claim 5, characterized in that: It also includes a reinforcing plate (22), and a plurality of groups of reinforcing plates (22) are arranged between the supporting legs (17) and the supporting base (18).

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