Antibacterial peptide centrifugal precipitation device

Abstract

The utility model discloses an antibacterial peptide centrifugal precipitation device, and relates to the technical field of precipitation devices, the antibacterial peptide centrifugal precipitation device comprises a bottom plate, the top end of the bottom plate is rotatably provided with a first clamping sleeve, the bottom end of the first clamping sleeve is fixedly provided with a rotating shaft, the surface of the rotating shaft is fixedly provided with a fixing ring, the outer side of the first clamping sleeve is movably provided with a second clamping sleeve, and the second clamping sleeve is fixedly provided with a fixing ring. At least two positioning blocks are fixedly installed at the bottom end of a second clamping sleeve, at least two first sleeve frames are fixedly installed at the bottom end of the second clamping sleeve, at least two second sleeve frames are fixedly installed at the top end of a fixing ring, and an inserting plate is driven by pulling a rotating rod to slide in the first sleeve frames. The first sleeve frame leaves the interiors of the first sleeve frame and the second sleeve frame, the second clamping sleeve is pulled upwards, the second clamping sleeve moves upwards at the top end of the fixing ring, the positioning block leaves the interior of the butt joint plate, the first clamping sleeve and the second clamping sleeve are separated, the structure is simple, operation is convenient, and rapid combination and fixation can be achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of precipitation devices, in particular to an antimicrobial peptide centrifugal precipitation device. Background Art

[0002] Antimicrobial peptides originally refer to a class of alkaline polypeptide substances with antimicrobial activity that are induced in insects. They have a molecular weight of about 2000 to 7000 and are composed of 20 to 60 amino acid residues. Most of these active polypeptides have the characteristics of strong alkalinity, thermal stability, and broad-spectrum antibacterial. In the preparation process of antimicrobial peptides, centrifugal precipitation treatment is required, and the supernatant is taken for another centrifugal precipitation treatment. The antimicrobial peptides contained in the supernatant obtained in the end have a higher purity.

[0003] At present, the existing centrifugal sedimentation device (such as patent number: CN211914207U) discloses an antimicrobial peptide centrifugal sedimentation device, in which multiple test tubes can be fixed in multiple mounting holes, and the efficiency of centrifugal sedimentation of antimicrobial peptides is improved. The test tubes are inserted into the mounting holes, the bottoms of the test tubes are against the base, and the tops of the test tubes are fixed by the top covers, so that the test tubes are fixed relatively firmly.

[0004] However, in the process of implementing the above technical solution, it was found that there were at least the following technical problems: the number of mounting holes for fixing test tubes inside the equipment is fixed, and only a few test tubes can be centrifuged at a time. When there are many samples, it takes a long time to complete the centrifugal sedimentation operation for a batch, delaying the production progress. Utility Model Content

[0005] 1. Technical issues to be resolved

[0006] In view of the deficiencies in the prior art, the utility model provides an antimicrobial peptide centrifugal precipitation device to solve the technical problems that the number of mounting holes for fixing test tubes inside the equipment is fixed, and only a few test tubes can be centrifuged for precipitation at a time. When there are many samples, it takes a long time to complete the centrifugal precipitation operation for a batch, thus delaying the production progress.

[0007] (II) Technical solution

[0008] In order to achieve the above objectives, the present invention is implemented through the following technical solutions:

[0009] An antimicrobial peptide centrifugal precipitation device comprises a bottom plate, a first ferrule is rotatably mounted on the top end of the bottom plate, a rotating shaft is fixedly mounted on the bottom end of the first ferrule, a fixing ring is fixedly mounted on the surface of the rotating shaft, a second ferrule is movably mounted on the outer side of the first ferrule, at least two positioning blocks are fixedly mounted on the bottom end of the second ferrule, at least two first sleeve frames are fixedly mounted on the bottom end of the second ferrule, and at least two second sleeve frames are fixedly mounted on the top end of the fixing ring.

[0010] Preferably: a plug plate is slidably installed inside each of the second sleeve frames, a rotating rod is rotatably installed on the outer side of each of the plug plates, a driving rod is rotatably installed on both side ends of each of the plug plates, a sliding block is rotatably installed on the surface of each driving rod, at least two positioning rings are fixedly installed on the top of the first sleeve, at least two docking plates are fixedly installed on the top of the fixing ring, and at least two supporting rods are fixedly installed inside the second sleeve.

[0011] (III) Beneficial effects

[0012] 1. By rotating the rotating rod, the rotating rod is rotated inside the plug-in board. The bevel gear installed on the top of the plug-in board is rotatably connected with the top of the driving rod. The rotating driving rod pushes the slider to slide on the side end of the plug-in board, and the slider is inserted between the second set frame and the first set frame to limit the movement of the plug-in board, so that the plug-in board can limit the positioning of the second ferrule and the fixing ring. The second ferrule is installed in combination with the first ferrule. The number of positioning rings can be adjusted according to needs to increase the flexibility of use.

[0013] 2. Pull the rotating rod to drive the plug-in board to slide inside the first frame, so that the first frame leaves the first frame and the second frame. Pull the second ferrule upward to move the second ferrule upward on the top of the fixed ring, and the positioning block leaves the inside of the docking plate to separate the first ferrule from the second ferrule. The structure is simple, easy to operate, and can be quickly assembled and fixed. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] The above description is only an overview of the technical solution of the utility model. In order to more clearly understand the technical means of the utility model and implement it according to the contents of the specification, the following is a detailed description of the preferred embodiments of the utility model in conjunction with the accompanying drawings.

[0015] Figure 1 This is a structural diagram of the bottom plate of the utility model;

[0016] Figure 2 This is a structural diagram of the ferrule of the utility model;

[0017] Figure 3 This is a structural diagram of the fixing ring of the utility model;

[0018] Figure 4 It is a structural diagram of the plug board of the utility model.

[0019] Legend: 1. Base plate; 11. First clamping sleeve; 12. Second clamping sleeve; 13. Positioning ring; 14. Support rod; 15. Positioning block; 16. First set frame; 17. Rotating shaft; 18. Fixed ring; 19. Docking plate; 21. Rotating rod; 22. Plug-in board; 23. Driving rod; 24. Sliding block; 25. Second set frame. DETAILED DESCRIPTION

[0020] The embodiment of the present application provides an antimicrobial peptide centrifugal precipitation device, which effectively solves the problem that the number of mounting holes for fixing test tubes inside the equipment is fixed, and only a few test tubes can be centrifuged at a time. When there are many samples, it takes a long time to complete the centrifugal precipitation operation for a batch, which delays the production progress. The rotating rod is rotated to rotate inside the plug-in board, and a bevel gear is installed on the top of the plug-in board and is rotatably connected to the top of the driving rod. The rotating driving rod pushes the slider to slide on the side end of the plug-in board, and the slider is clamped between the second frame and the first frame to limit the movement of the plug-in board, so that the plug-in board plays a role in limiting the positioning of the second ferrule and the fixing ring. The second ferrule is installed in combination with the first ferrule, and the number of positioning rings can be adjusted according to needs to increase the flexibility of use.

[0021] Example

[0022] like Figure 1 , Figure 2 , Figure 3 and Figure 4 As shown, the technical solution in the embodiment of the present application effectively solves the technical problem that the number of mounting holes for fixing test tubes inside the equipment is fixed, and only a few test tubes can be centrifuged at a time. When there are many samples, it takes a long time to complete the centrifugal precipitation operation for a batch, which delays the production progress. The overall idea is as follows:

[0023] In view of the problems existing in the prior art, the utility model provides an antimicrobial peptide centrifugal precipitation device, comprising a bottom plate 1, a first ferrule 11 is rotatably installed on the top of the bottom plate 1, a rotating shaft 17 is fixedly installed on the bottom end of the first ferrule 11, a fixing ring 18 is fixedly installed on the surface of the rotating shaft 17, a second ferrule 12 is movably installed on the outside of the first ferrule 11, the first ferrule 11 and the second ferrule 12 are combined and installed, the number of positioning rings 13 that can be used in the device is increased, and a test tube is inserted into the first ferrule 11 and the second ferrule 12 respectively, and the rotating shaft 17 is driven to rotate by a motor, so that the first ferrule 11 and the fixing ring 18 rotate around the rotating shaft 17 at the same time, and a centrifugal precipitation operation is performed, at least two positioning blocks 15 are fixedly installed on the bottom end of the second ferrule 12, at least two first sleeve frames 16 are fixedly installed on the bottom end of the second ferrule 12, the first sleeve frame 16 and the positioning blocks 15 are cross-designed with each other, and at least two second sleeve frames 25 are fixedly installed on the top of the fixing ring 18.

[0024] A plug board 22 is slidably installed inside each second frame 25. By pushing the plug board 22, one end of the plug board 22 is fitted with the first frame 16, and the plug board 22 slides inside the first frame 16 to pass through the inside of the first frame 16. After the plug board 22 slides, the end of the plug board 22 is inserted into the inside of the second frame 25. A rotating rod 21 is rotatably installed on the outside of each plug board 22, and a driving rod 23 is rotatably installed on the two side ends of each plug board 22. A slider 24 is rotatably installed on the surface of each driving rod 23. At least two positioning rings 13 are fixedly installed on the top of the first ferrule 11, and at least two docking plates 19 are fixedly installed on the top of the fixing ring 18. The interior of the docking plate 19 is fitted and engaged with the bottom end of the positioning block 15, and at least two support rods 14 are fixedly installed inside the second ferrule 12.

[0025] Working principle:

[0026] The first step is to move the second ferrule 12 to align the inner side of the second ferrule 12 with the first ferrule 11 when in use, and press the second ferrule 12 downward to allow the second ferrule 12 to slide downward along the first ferrule 11. At the same time, in the process of pushing the second ferrule 12 to slide downward, rotate the second ferrule 12 to allow the second ferrule 12 to drive the positioning block 15 and the docking plate 19 to align with each other, insert the positioning block 15 into the inside of the docking plate 19, and at the same time, align the first set frame 16 and the second set frame 25 at the bottom of the second ferrule 12 with each other, push the plug-in board 22 to fit one end of the plug-in board 22 with the first set frame 16, slide inside the first set frame 16, and pass the plug-in board 22 through the first set frame After the plug-in board 22 slides inside the frame 16, the end of the plug-in board 22 is inserted into the second set frame 25, and the rotating rod 21 is rotated to rotate inside the plug-in board 22. The top of the plug-in board 22 is installed with a bevel gear and is rotatably connected to the top of the driving rod 23. The rotating driving rod 23 pushes the slider 24 to slide on the side end of the plug-in board 22, and the slider 24 is inserted between the second set frame 25 and the first set frame 16 to limit the movement of the plug-in board 22, so that the plug-in board 22 plays a role in limiting the positioning of the second ferrule 12 and the fixing ring 18. The second ferrule 12 is installed in combination with the first ferrule 11, and the number of positioning rings 13 can be adjusted according to needs to increase the flexibility of use.

[0027] In the second step, the first ferrule 11 and the second ferrule 12 are assembled and installed to increase the number of positioning rings 13 that can be used in the device. The test tubes are respectively inserted into the first ferrule 11 and the second ferrule 12, and the rotating shaft 17 is driven by the motor to rotate, so that the first ferrule 11 and the fixing ring 18 rotate around the rotating shaft 17 at the same time to perform centrifugal sedimentation operation. By rotating the rotating rod 21, the rotating rod 21 is rotated in the opposite direction at the side end of the plug-in board 22, and the two driving rods 23 are driven to rotate in the opposite direction. The driving rod 23 rotates in the opposite direction to apply a pulling force to the slider 24. , let the slider 24 slide between the second frame 25 and the first frame 16 into the interior of the plug-in board 22, and drive the plug-in board 22 to slide inside the first frame 16 by pulling the rotating rod 21, so that the first frame 16 leaves the interior of the first frame 16 and the second frame 25, and by pulling the second clamping sleeve 12 upward, the second clamping sleeve 12 moves upward on the top of the fixing ring 18, and the positioning block 15 leaves the interior of the docking plate 19, and the first clamping sleeve 11 is separated from the second clamping sleeve 12. The structure is simple, easy to operate, and can be quickly assembled and fixed.

[0028] Finally, it should be noted that: Obviously, the above embodiments are only examples for clearly explaining the present invention, and are not intended to limit the implementation methods. For ordinary technicians in the relevant field, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived from this are still within the scope of protection of the present invention.

Claims

1. An antimicrobial peptide centrifugal precipitation device, comprising a bottom plate (1), characterized in that: A first ferrule (11) is rotatably mounted on the top of the base plate (1), a rotating shaft (17) is fixedly mounted on the bottom of the first ferrule (11), a fixing ring (18) is fixedly mounted on the surface of the fixing shaft (17), a second ferrule (12) is movably mounted on the outer side of the first ferrule (11), at least two positioning blocks (15) are fixedly mounted on the bottom of the second ferrule (12), at least two first sleeve frames (16) are fixedly mounted on the bottom of the second ferrule (12), and at least two second sleeve frames (25) are fixedly mounted on the top of the fixing ring (18); The first frame (16) and the positioning block (15) are designed to cross each other.

2. The antimicrobial peptide centrifugal precipitation device according to claim 1, characterized in that: A plug-in board (22) is slidably mounted inside each of the second sets of frames (25), and a rotating rod (21) is rotatably mounted on the outer side of each of the plug-in boards (22); The plug board (22) penetrates the interior of the first set frame (16) and the second set frame (25) after the first set frame (16) and the second set frame (25) are aligned.

3. The antimicrobial peptide centrifugal precipitation device according to claim 2, characterized in that: A driving rod (23) is rotatably mounted on both side ends of each plug-in board (22), and a sliding block (24) is rotatably mounted on the surface of each driving rod (23); Wherein, a bevel gear is installed on the top end of the driving rod (23) and is connected to the rotating rod (21).

4. The antimicrobial peptide centrifugal precipitation device according to claim 1, characterized in that: At least two positioning rings (13) are fixedly mounted on the top end of the first ferrule (11); A plurality of positioning rings (13) are also installed at the top end of the second ferrule (12), and the first ferrule (11) and the second ferrule (12) are designed to be staggered with each other.

5. The antimicrobial peptide centrifugal precipitation device according to claim 1, characterized in that: At least two docking plates (19) are fixedly mounted on the top end of the fixing ring (18); The interior of the docking plate (19) is engaged and snap-fitted with the bottom end of the positioning block (15).

6. The antimicrobial peptide centrifugal precipitation device according to claim 1, characterized in that: At least two support rods (14) are fixedly mounted inside the second ferrule (12).

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