Palonosetron hydrochloride crude product dissolving device

Abstract

The utility model relates to the technical field of medicine dissolving, and particularly discloses a palonosetron hydrochloride crude product dissolving device which comprises a dissolving tank for dissolving a target object, a bearing plate arranged on the inner side of the dissolving tank, and an injection pipe mounted on the bearing plate, the dissolving tank comprises a tank body, and a feeding hole is formed in the top of the tank body and is used for introducing a target object and liquid for dissolving; the part, close to the lower part, of the inner side of the tank body is clamped and matched with a bearing plate; according to the utility model, through the arrangement of the bearing plate and the arrangement of the injection pipe, when the bearing plate and the injection pipe are combined, a solution can be smoothly stirred by utilizing the combination of the arranged pipeline and the injection orifice and filling of gas, and the magnetic stirring accommodating area arranged on the bearing plate is matched with the magnetic stirrer arranged through magnetic stirring, so that the solution can be uniformly stirred. According to the stirring device, the requirement for stirring a solution is met, the stirring efficiency is improved, stirring of gas is disordered bubble impact, and drugs can be better dissolved.

Description

Technical Field

[0001] The utility model relates to the technical field of drug dissolution, in particular to a crude palonosetron hydrochloride dissolution device. Background Art

[0002] Palonosetron hydrochloride is a drug that usually exists in the form of powder or crystals. Its solubility can be affected by solvents, temperature and other factors. Generally speaking, palonosetron hydrochloride is soluble in water.

[0003] The crude product of palonosetron hydrochloride contains more impurities. In order to improve the purity of palonosetron hydrochloride, it needs to be dissolved and crystallized before processing. The common dissolution method is to stir it, but it can often only be processed at one angle or direction, resulting in insufficient dissolution efficiency. Based on this, it needs to be improved. Utility Model Content

[0004] In view of the shortcomings of the prior art, the utility model provides a crude palonosetron hydrochloride dissolving device, which solves the problem that the prior art can only process at one angle or direction, resulting in insufficient dissolution efficiency.

[0005] The crude palonosetron hydrochloride dissolving device of the utility model comprises a dissolving tank for dissolving a target object, a carrying plate arranged inside the dissolving tank, and a spray pipe installed on the carrying plate;

[0006] The dissolving tank comprises a tank body, and a feed port is provided on the top of the tank body for introducing the target object and liquid for dissolution;

[0007] The inner side of the tank body is connected and adapted to the bearing plate near the bottom, and the bearing plate includes a plate body, and the outer periphery of the plate body is provided with an outer ring protruding outwards for fixing the plate body;

[0008] The top of the plate body is provided with mounting plates in a circular array, and the top of the mounting plates is adapted to the injection pipe for stirring the solution for dissolving the target object.

[0009] As a further improvement of the utility model, one or more strip holes are opened in a circular array on the top of the plate body, and a magnetic stirring placement area is provided at one end where the plurality of strip holes are close to each other for installing a magnetic stirrer.

[0010] As a further improvement of the utility model, the injection pipe comprises a pipeline, an inner side of the outer side of the pipeline is provided with an inner cavity, and one or more injection ports are opened on the outer side of the pipeline for gas agitation of the target object and the liquid.

[0011] As a further improvement of the utility model, a support frame is provided at the bottom of the pipeline, and the bottom of the support frame is adapted to the bottom of the mounting plate to maintain the stability of the pipeline.

[0012] As a further improvement of the utility model, a hollow interlayer is provided on the inner side of the tank body, a heat conducting plate is provided on the inner side of the hollow interlayer, and a heat conducting medium is also filled in the hollow interlayer, so as to improve the dissolution degree of the target object.

[0013] As a further improvement of the utility model, the bottom of the tank body is provided with supporting feet, and the bottom of the tank body is provided with a discharge port located inside the supporting feet for discharging the dissolved target object.

[0014] Compared with the prior art, the beneficial effects of the utility model are as follows:

[0015] The utility model uses a supporting plate and a spray pipe, and when they are combined, utilizes a combination of the pipe and the spray port, and injects gas to enable the solution to be stirred smoothly. The magnetic stirring accommodating area arranged on the supporting plate, through magnetic stirring and a magnetic stirrer arranged, realizes the need for stirring the solution, improves the stirring efficiency, and the agitation of the gas is disordered bubble impact, which can better dissolve the medicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The drawings described herein are used to provide a further understanding of the present application and constitute a part of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings:

[0017] Figure 1 This is a schematic diagram of the three-dimensional structure of the dissolving tank of the utility model;

[0018] Figure 2 This is a schematic diagram of the front view structure of the dissolving tank of the utility model;

[0019] Figure 3 For this utility model Figure 2 Schematic diagram of the AA section structure;

[0020] Figure 4 This is a schematic diagram of the structure of the dissolving tank of the utility model when viewed from above;

[0021] Figure 5 This is a schematic diagram of the top view of the dissolving tank of the utility model;

[0022] Figure 6 This is a schematic diagram of the three-dimensional structure of the injection pipe of the utility model;

[0023] Figure 7 This is a schematic diagram of the front view structure of the injection pipe of the utility model;

[0024] Figure 8 For this utility model Figure 7 Schematic diagram of the AA section structure;

[0025] Fig. 9 This is a schematic diagram of the three-dimensional structure of the load-bearing plate of the utility model;

[0026] Fig.10 This is a schematic diagram of the top view of the structure of the load-bearing plate of the utility model;

[0027] Fig.11 This is a side view structural diagram of the load-bearing plate of the utility model;

[0028] Fig.12 For this utility model Figure 3 Enlarged structural diagram at A in the middle.

[0029] In the figure: 1. dissolving tank; 2. carrying plate; 3. injection pipe;

[0030] 11. Tank body; 12. Feed inlet; 13. Support legs; 14. Discharge outlet; 15. Hollow interlayer; 16. Heat conduction plate;

[0031] 21. Plate body; 22. Mounting plate; 23. Magnetic stirring placement area; 24. Outer ring; 25. Strip holes;

[0032] 31. Injection port; 32. Pipe; 33. Support frame; 34. Inner cavity. DETAILED DESCRIPTION

[0033] The following will disclose multiple embodiments of the utility model with diagrams. For the purpose of clear description, many physical details will be described together in the following description. However, it should be understood that these physical details should not be used to limit the utility model. In other words, in some embodiments of the utility model, these physical details are not necessary. In addition, for the purpose of simplifying the diagram, some conventional structures and components will be depicted in a simple schematic manner in the diagram.

[0034] In addition, the technical solutions between the various embodiments can be combined with each other, but it must be based on the fact that ordinary technicians in this field can implement it. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such combination of technical solutions does not exist and is not within the scope of protection required by the present utility model.

[0035] See also Figure 1 , Figure 2 , Figure 3 , Figure 4 as well as Figure 5, crude palonosetron acid is a product of palonosetron hydrochloride containing more impurities. In order to improve the purity of palonosetron hydrochloride, it needs to be dissolved and crystallized before processing, and the common dissolution measures are to process by stirring, but it can often only be processed at one angle or direction, resulting in insufficient dissolution efficiency. Based on this, the present application provides a crude palonosetron hydrochloride dissolution device, including a dissolution tank 1 for dissolving a target object and a carrier plate 2 arranged on the inner side of the dissolution tank 1, and an injection pipe 3 installed on the carrier plate 2;

[0036] The dissolving tank 1 comprises a tank body 11, and a feed port 12 is provided on the top of the tank body 11 for introducing the target object and liquid for dissolution;

[0037] The inner side of the tank body 11 is snap-fitted with the carrier plate 2 near the bottom. The carrier plate 2 includes a plate body 21. The outer periphery of the plate body 21 is provided with an outer ring 24 protruding outwards for fixing the plate body 21.

[0038] The top of the plate body 21 is provided with a mounting plate 22 in a ring array, and the top of the mounting plate 22 is adapted to the injection pipe 3 for stirring the solution for dissolving the target object.

[0039] Place the tank body 11 of the dissolving tank 1 on the working area and ensure that the feed port 12 is at the top. Then, snap-fit ​​the support plate 2 to the inner side of the tank body 11 near the bottom to ensure that the support plate 2 is firmly fixed inside the tank body 11.

[0040] Next, crude Palonosetron hydrochloride is placed in the dissolution tank 1, and then the required solvent, such as water or other solvents, is injected into the tank body 11 until the liquid level exceeds the target object. Note that the dissolved solution reaches the required concentration and volume.

[0041] On top of the carrier plate 2, the injection tube 3 is installed to fit the annular array of the mounting plate 22. The injection tube 3 should be located above the surface of the solution so that the injection gas can fully stir the crude Palonosetron Hydrochloride in the solution.

[0042] The gas supply system of the injection tube 3 is started to inject gas into the solution. The injection of gas will generate disordered bubble impact, effectively promote the stirring of the solution, and help the crude palonosetron hydrochloride to dissolve quickly.

[0043] By properly adjusting the flow rate and injection direction of the gas supply system, the dissolution rate and efficiency of the crude palonosetron hydrochloride in the dissolving solution can be controlled.

[0044] By combining gas injection and magnetic stirring, the solution can be effectively stirred in more directions, thereby improving the dissolution efficiency of crude palonosetron hydrochloride. Compared with traditional stirring equipment, this device can complete the dissolution process in a shorter time, and may also reduce energy consumption and improve production efficiency. Through the combined effect of gas injection and magnetic stirring, a more uniform and delicate dissolution process can be achieved, avoiding the problem of excessive local concentration differences in the solution and ensuring the uniformity of the solution. The operation of this device is relatively simple. Only by starting the gas supply system and the magnetic stirrer can the solution be effectively stirred without the need for complicated operating steps and equipment.

[0045] See also Figure 1 , Figure 2 , Figure 3 , Fig. 9 , Fig.10 , Fig.11 as well as Fig.12 The top of the plate body 21 is provided with one or more strip holes 25 in a circular array, and a magnetic stirring placement area 23 is provided at one end where the plurality of strip holes 25 are close to each other for installing a magnetic stirrer.

[0046] Select the appropriate number and position of strip holes 25, punch holes on the carrier plate 2 as needed, ensure that they are arranged in a ring, place the magnetic stirrer in the placement area of ​​the strip holes 25, and ensure that they are flush with the bottom of the hole to ensure that the stirrer can effectively stir in the dissolved liquid, after setting up the magnetic stirrer, install the carrier plate 2 to the inner side of the dissolving tank 1 near the bottom, ensure that the carrier plate 2 is firmly fixed inside the tank body 11, and generate a magnetic field by controlling the power supply of the magnetic stirrer to stir the crude Palonosetron Hydrochloride in the dissolved liquid. The magnetic stirrer will rotate on the carrier plate 2 to produce a sufficient stirring effect on the dissolved liquid.

[0047] By arranging a magnetic stirrer on the supporting plate 2, the stirring effect of the dissolved liquid can be enhanced, the crude palonosetron hydrochloride can be dissolved faster, and the uniformity of the dissolution process can be ensured. The installation method of the magnetic stirrer makes the entire device structure more compact and saves space. Especially for places with limited space such as laboratories or production workshops, this design is more advantageous. Compared with traditional mechanical stirring devices, the magnetic stirrer does not need to set a stirring shaft inside the dissolution tank 1, which reduces the mechanical friction caused by rotating parts and reduces the safety risks during operation.

[0048] See also Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Fig. 9The injection pipe 3 includes a pipe 32, an inner cavity 34 is arranged on the inner side of the outer side of the pipe 32, and one or more injection ports 31 are opened on the outer side of the pipe 32 for gas agitation of the target object and the liquid.

[0049] A support frame 33 is provided at the bottom of the pipeline 32 , and the bottom of the support frame 33 is adapted to the bottom of the mounting plate 22 to keep the pipeline 32 stable.

[0050] The pipe 32 is the main part of the injection pipe 3, and the inner cavity 34 outside the pipe 32 is the channel for gas flow. The design of the inner cavity 34 should ensure that the gas can flow smoothly and achieve the desired injection effect. The injection port 31 is located on the outside of the pipe 32. The gas is injected into the dissolved liquid through the injection port 31 to generate bubble impact, thereby achieving stirring of the dissolved liquid. The number and position of the injection ports 31 can be designed and adjusted according to actual needs. In order to maintain the stability of the injection pipe 3, a support frame 33 is provided at the bottom of the pipe 32. The bottom of the support frame 33 is adapted to the bottom of the mounting plate 22, so that the injection pipe 3 can be stably mounted on the supporting plate 2, and will not produce excessive swing or vibration due to gas injection.

[0051] The injection pipe 3 is mounted on the top of the mounting plate 22 of the carrier plate 2, and the injection port 31 is ensured to be located above the surface of the dissolved liquid so that the injected gas can fully stir the dissolved liquid, and the gas is injected into the injection pipe 3. The gas flows through the inner cavity 34 of the pipe 32 and is ejected from the injection port 31, generating bubble impact, thereby promoting the stirring of the dissolved liquid. By adjusting the flow rate and injection direction of the gas supply system, the dissolution rate and efficiency of the crude palonosetron hydrochloride in the dissolved liquid can be controlled.

[0052] The injection tube 3 can achieve efficient stirring of the dissolved liquid through the bubble impact generated by the injection gas, thereby promoting the rapid dissolution of the crude palonosetron hydrochloride and improving production efficiency. The injection port 31 of the injection tube 3 is arranged on the outside of the pipeline 32, and can spray gas into the dissolved liquid from multiple directions to ensure the uniform dissolution of the crude palonosetron hydrochloride in the dissolved liquid and avoid the problem of excessive local concentration differences. The setting of the support frame 33 ensures the stability of the injection tube 3 during operation and reduces the uneven bubble injection or unstable dissolution effect caused by the shaking of the pipeline 32. By adjusting the flow rate and injection direction of the gas supply system, the stirring effect of the injection tube 3 can be flexibly controlled to meet the needs of different dissolution processes.

[0053] See also Figure 1 , Figure 2 , Fig.12 A hollow interlayer 15 is disposed inside the tank body 11 , a heat conducting plate 16 is disposed inside the hollow interlayer 15 , and a heat conducting medium is also filled in the hollow interlayer 15 , so that the user can improve the dissolution degree of the target object.

[0054] A supporting foot 13 is disposed at the bottom of the tank body 11 , and a discharge port 14 is disposed at the bottom of the tank body 11 and inside the supporting foot 13 , for discharging the dissolved target object.

[0055] The heat conducting plate 16 is used to uniformly heat the dissolving liquid to promote the dissolving process of the target object. The existence of the heat conducting plate 16 can effectively improve the temperature uniformity of the dissolving liquid and avoid the problem that the local temperature is too high or too low and affects the dissolving effect.

[0056] The hollow interlayer 15 is filled with a heat-conducting medium, such as hot water or other heat-conducting liquids. These heat-conducting media can absorb and conduct heat during the heating process, help maintain the temperature of the dissolved liquid stable, and ensure that the target object is dissolved at a suitable temperature. The bottom of the tank body 11 is provided with a support foot 13, and the bottom of the inner side of the support foot 13 is provided with a discharge port 14 for outputting the dissolved target object. The design of the support foot 13 ensures the stability and balance of the dissolving tank 1 during use, and the setting of the discharge port 14 facilitates the removal and subsequent processing of the dissolved liquid.

[0057] The crude Palonosetron hydrochloride to be dissolved is placed in the tank body 11, and then the required solvent, such as water or other solvents, is injected into the tank body 11 until the liquid surface covers the target object.

[0058] The heat conducting plate 16 starts to heat up. The heat conducting medium conducts heat to the dissolving liquid during the heating process to promote the dissolving process of the target. At the same time, the temperature of the heating system is kept within a suitable range to prevent the temperature of the dissolving liquid from being too high or too low.

[0059] When the target object is completely dissolved, the dissolved liquid is taken out through the discharge port 14 for subsequent processing or production process. The design of the hollow interlayer 15, the heat conducting plate 16 and the heat conducting medium can achieve uniform heating of the dissolved liquid, thereby improving the dissolution speed and efficiency of the target object. The presence of the heat conducting medium can help maintain the temperature stability of the dissolved liquid, avoid the influence of temperature fluctuations on the dissolution process, and ensure the stability and consistency of the dissolution process. The setting of the support feet 13 and the discharge port 14 at the bottom of the tank body 11 makes it more convenient and quick to take out the dissolved liquid, simplifies the operation process, and improves the operation efficiency.

[0060] The above description is only an embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent substitution, improvement, etc. made within the spirit and principle of the present invention shall be included in the scope of the claims of the present invention.

Claims

1. A crude palonosetron hydrochloride dissolving device, comprising a dissolving tank (1) for dissolving a target object, a supporting plate (2) arranged inside the dissolving tank (1), and a spray pipe (3) mounted on the supporting plate (2); Features: The dissolving tank (1) comprises a tank body (11), and a feed port (12) is provided on the top of the tank body (11) for introducing a target object and a liquid for dissolution; The inner side of the tank body (11) is snap-fitted with the carrier plate (2) near the bottom, and the carrier plate (2) comprises a plate body (21), and the outer periphery of the plate body (21) is provided with an outer ring (24) protruding outwards, which is used to fix the plate body (21); The top of the plate body (21) is provided with a mounting plate (22) in a ring array, and the top of the mounting plate (22) is adapted to the injection pipe (3) for stirring the solution for dissolving the target object.

2. A crude palonosetron hydrochloride dissolving device according to claim 1, characterized in that: The top of the plate body (21) is provided with one or more strip holes (25) in a circular array, and a magnetic stirring placement area (23) is provided at one end where the plurality of strip holes (25) are close to each other for installing a magnetic stirrer.

3. A crude palonosetron hydrochloride dissolving device according to claim 1, characterized in that: The injection pipe (3) comprises a pipe (32), an inner cavity (34) is arranged on the inner side of the outer side of the pipe (32), and one or more injection ports (31) are opened on the outer side of the pipe (32) for gas agitation of the target object and the liquid.

4. A crude palonosetron hydrochloride dissolving device according to claim 3, characterized in that: A support frame (33) is provided at the bottom of the pipeline (32), and the bottom of the support frame (33) is adapted to the bottom of the mounting plate (22) to maintain the stability of the pipeline (32).

5. A crude palonosetron hydrochloride dissolving device according to claim 1, characterized in that: A hollow interlayer (15) is arranged on the inner side of the tank body (11), a heat conducting plate (16) is arranged on the inner side of the hollow interlayer (15), and a heat conducting medium is also filled in the hollow interlayer (15), so as to improve the dissolution degree of the target object.

6. A crude palonosetron hydrochloride dissolving device according to claim 1, characterized in that: The bottom of the tank body (11) is provided with supporting feet (13), and the bottom of the tank body (11) is provided with a discharge port (14) located inside the supporting feet (13) for discharging the dissolved target object.

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