Showerhead system for oligonucleotide synthesis

Abstract

The utility model relates to the technical field of spray heads, and discloses a spray head system for oligonucleotide synthesis, which comprises a spray head, a plurality of first electromagnetic valves; one end of each synthetic reagent container is connected with the other end of the first normally open circuit, and the other end is connected with an ink-jet pressure pipeline; a second solenoid valve; one end of the cleaning reagent container is connected with the other end of the second normally open circuit, and the other end is connected with a cleaning pressure pipeline; the first electromagnetic valve is in a normally open mode, so that the spray head system has an oligonucleotide synthesis mode; the first electromagnetic valve is in a normally-closed mode, and the second electromagnetic valve is in a normally-open mode, so that the spray head system has a cleaning mode. The first electromagnetic valve and the second electromagnetic valve are arranged in the spray head system, so that one set of spray head system can synthesize oligonucleotide or clean the spray head according to requirements, and the convenience of cleaning the spray head is greatly improved.

Description

Technical Field

[0001] The utility model relates to the technical field of nozzles, in particular to a nozzle system for oligonucleotide synthesis. Background Art

[0002] The use of commercial printheads represents a major advance in oligonucleotide synthesis technology, a method similar to the technology used in inkjet printers to precisely deposit tiny droplets of ink onto paper. In oligonucleotide synthesis, the printhead deposits chemicals in a specific pattern onto a solid surface such as glass to synthesize oligonucleotides. This method can rapidly synthesize thousands of unique oligonucleotides simultaneously on a single chip or surface, greatly increasing yields and reducing costs.

[0003] However, when using inkjet printing nozzles to synthesize oligonucleotides, there are also problems with unblocking the nozzles and preventing them from clogging. There are three main mechanisms on the market for cleaning and unblocking nozzles: integral liquid-absorbing ink stacks, manual cleaning modules, and ultrasonic cleaning machines. None of these three cleaning and unblocking mechanisms can match the application scenarios of oligonucleotide synthesis well. Among them, although the integral liquid-absorbing ink stack has a large liquid-absorbing area and high liquid-absorbing efficiency, it cannot form a uniform liquid-absorbing pressure, which can easily cause some nozzles to be unable to absorb; although the manual cleaning module has the lowest price, it is mostly made of stainless steel that is not suitable for long-term contact with organic solvents, and the manual cleaning pressure is difficult to control and may exceed the allowable pressure of the nozzle; the third type of ultrasonic cleaning requires the nozzle to be removed, which is time-consuming and labor-intensive. After reinstallation, the nozzle needs to be realigned, which is very inconvenient for equipment that can synthesize with 5 to 6 nozzles at a time. Utility Model Content

[0004] In view of this, the utility model provides a nozzle system for oligonucleotide synthesis to solve the problem that the nozzle is inconvenient to clean.

[0005] The utility model provides a nozzle system for oligonucleotide synthesis, comprising:

[0006] Sprinklers;

[0007] A plurality of first solenoid valves, wherein the first solenoid valves include a first normally closed circuit, a first normally open circuit and a first outlet, wherein one end of the first normally closed circuit is suitable for being connected to the spray head through a connecting pipe via the first outlet, so that the first solenoid valve has a normally closed mode, or one end of the first normally open circuit is suitable for being connected to the spray head through a connecting pipe via the first outlet, so that the first solenoid valve has a normally open mode;

[0008] A plurality of synthesis reagent containers, one end of which is connected to the other end of the first normally open circuit, and the other end of which is connected to the inkjet pressure pipeline, the synthesis reagent containers and the first solenoid valves are arranged in a one-to-one correspondence, the synthesis reagent containers are suitable for accommodating synthesis reagents, and the inkjet pressure pipeline is suitable for driving the synthesis reagents to flow toward the nozzle in the oligonucleotide synthesis mode;

[0009] a second solenoid valve, the second solenoid valve comprising a second normally closed circuit, a second normally open circuit and a second outlet, one end of the second normally closed circuit being suitable for being connected to the other end of the first normally closed circuit via the second outlet, so that the second solenoid valve has a normally closed mode, or one end of the second normally open circuit being suitable for being connected to the other end of the first normally closed circuit via the second outlet, so that the second solenoid valve has a normally open mode;

[0010] A cleaning reagent container, one end of which is connected to the other end of the second normally open circuit, and the other end of which is connected to a cleaning pressure pipeline, wherein the cleaning reagent container is suitable for containing a cleaning reagent, and the cleaning pressure pipeline is suitable for driving the cleaning reagent to flow toward the nozzle in a cleaning mode;

[0011] The first solenoid valve is in the normally open mode so that the nozzle system has the synthetic oligonucleotide mode; the first solenoid valve is in the normally closed mode, and the second solenoid valve is in the normally open mode so that the nozzle system has the cleaning mode.

[0012] Beneficial effect: by arranging the first solenoid valve and the second solenoid valve in the nozzle system, when the first solenoid valve is in the normally open mode, the nozzle system has the oligonucleotide synthesis mode, and when the first solenoid valve is in the normally closed mode and the second solenoid valve is in the normally open mode, the nozzle system has a cleaning mode, so that a set of nozzle system can synthesize oligonucleotides or clean the nozzle according to needs, and there is no need to connect external cleaning equipment, disassemble the nozzle or clean it manually when the nozzle system needs to be cleaned, which greatly improves the convenience of nozzle cleaning.

[0013] In an optional embodiment, the inkjet pressure pipeline is suitable for circulating positive-pressure gas, and the cleaning pressure pipeline is suitable for circulating positive-pressure gas.

[0014] Beneficial effect: By setting up a positive-pressure gas circulation in the inkjet pressure pipeline, the positive-pressure gas can drive the synthesis reagent to flow toward the nozzle in the oligonucleotide synthesis mode. By setting up a positive-pressure gas circulation in the cleaning pressure pipeline, the positive-pressure gas can drive the cleaning reagent to flow toward the nozzle in the cleaning mode, which facilitates the drive and prevents backflow.

[0015] In an optional embodiment, the first solenoid valve and the second solenoid valve are two-position three-way solenoid valves, and the two-position three-way solenoid valves are suitable for converting a normally open mode to a normally closed mode after being energized.

[0016] Beneficial effect: By setting the first solenoid valve and the second solenoid valve as two-position three-way solenoid valves, the two-position three-way solenoid valves can be switched between the normally open mode and the normally closed mode when energized and de-energized, and the structure is relatively simple.

[0017] In an optional embodiment, the nozzle is a multi-color nozzle, and the first solenoid valve and the synthetic reagent container are provided in plurality respectively.

[0018] In an optional embodiment, a first flow-dividing structure is provided between the synthesis reagent container and the inkjet pressure pipeline, and a second flow-dividing structure is provided between the second solenoid valve and the first solenoid valve.

[0019] Beneficial effect: By setting a first diversion structure between the synthesis reagent container and the inkjet pressure pipeline, and setting a second diversion structure between the second solenoid valve and the first solenoid valve, it is possible to facilitate the distribution of synthesis reagents and cleaning reagents to multiple first solenoid valves, and the structure is relatively simple.

[0020] In an optional embodiment, the nozzle is a four-color nozzle, and the number of the synthesis reagent containers is 5, and the corresponding synthesis reagents are adenine, thymine, cytosine, guanine and an activator, respectively.

[0021] In an optional embodiment, the other end of the second normally closed circuit is connected to a blowing pressure pipeline, and the blowing pressure pipeline is suitable for blowing air into the nozzle in the blowing mode;

[0022] The first solenoid valve is in the normally closed mode, and the second solenoid valve is in the normally closed mode, so that the spray head system has the blowing mode.

[0023] Beneficial effect: By setting the air blowing pressure pipeline, the nozzle system can have an air blowing mode, so that the air blowing mode is run first after the oligonucleotide synthesis mode or the cleaning mode, so that the residual reagents in the pipeline and the nozzle are cleaned before cleaning or oligonucleotide synthesis, thereby preventing waste of reagents.

[0024] In an optional embodiment, the insufflation pressure pipeline is suitable for flowing positive pressure gas.

[0025] In an optional embodiment, the nozzle system includes:

[0026] A control system is connected to the first solenoid valve and the second solenoid valve, and is suitable for controlling the first solenoid valve and the second solenoid valve to be in the normally closed mode or the normally open mode.

[0027] Beneficial effect: By setting up a control system, the power on or off of the first solenoid valve and the second solenoid valve can be automatically controlled, and the synthetic oligonucleotide mode, cleaning mode and blowing mode of the nozzle system can be automatically switched, making the operation of the nozzle system more automated.

[0028] In an optional implementation, a one-way valve is provided on the connecting pipeline.

[0029] Beneficial effect: By setting a one-way valve on the connecting pipeline, the backflow of the reagent can be prevented, and the smooth flow of the reagent is ensured to achieve the normal operation of the oligonucleotide mode and the cleaning mode. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the specific implementation methods of the utility model or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0031] Figure 1 The present invention is a schematic structural diagram of a nozzle system for oligonucleotide synthesis according to an embodiment of the present invention.

[0032] Description of reference numerals:

[0033] 1. Nozzle; 2. First solenoid valve; 3. Synthesis reagent container; 4. Second solenoid valve; 5. Cleaning reagent container; 6. Inkjet pressure pipeline; 7. Cleaning pressure pipeline; 8. Air blowing pressure pipeline; 9. First diversion structure; 10. Second diversion structure. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all the embodiments. Based on the embodiment of the utility model, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the utility model.

[0035] Combine the following Figure 1 , describing an embodiment of the utility model.

[0036] According to an embodiment of the utility model, a nozzle system for oligonucleotide synthesis is provided, comprising:

[0037] Nozzle 1;

[0038] A plurality of first solenoid valves 2, wherein the first solenoid valves 2 include a first normally closed circuit, a first normally open circuit and a first outlet, wherein one end of the first normally closed circuit is suitable for being connected to the nozzle 1 through the first outlet through a connecting pipe, so that the first solenoid valve 2 has a normally closed mode, or one end of the first normally open circuit is suitable for being connected to the nozzle 1 through the connecting pipe through the first outlet, so that the first solenoid valve 2 has a normally open mode;

[0039] A plurality of synthesis reagent containers 3, one end of which is connected to the other end of the first normally open circuit, and the other end of which is connected to the inkjet pressure pipeline 6, the synthesis reagent containers 3 are arranged in a one-to-one correspondence with the first solenoid valve 2, the synthesis reagent containers 3 are suitable for accommodating the synthesis reagent, and the inkjet pressure pipeline 6 is suitable for driving the synthesis reagent to flow toward the nozzle 1 in the oligonucleotide synthesis mode;

[0040] A second solenoid valve 4, the second solenoid valve 4 comprises a second normally closed circuit, a second normally open circuit and a second outlet, one end of the second normally closed circuit is suitable for being connected to the other end of the first normally closed circuit via the second outlet, so that the second solenoid valve 4 has a normally closed mode, or one end of the second normally open circuit is suitable for being connected to the other end of the first normally closed circuit via the second outlet, so that the second solenoid valve 4 has a normally open mode;

[0041] A cleaning reagent container 5, one end of which is connected to the other end of the second normally open circuit, and the other end of which is connected to a cleaning pressure pipeline 7. The cleaning reagent container 5 is suitable for containing a cleaning reagent, and the cleaning pressure pipeline 7 is suitable for driving the cleaning reagent to flow toward the nozzle 1 in a cleaning mode;

[0042] The first solenoid valve 2 is in a normally open mode, so that the nozzle system has an oligonucleotide synthesis mode; the first solenoid valve 2 is in a normally closed mode, and the second solenoid valve 4 is in a normally open mode, so that the nozzle system has a cleaning mode.

[0043] By arranging the first solenoid valve 2 and the second solenoid valve 4 in the nozzle system, when the first solenoid valve 2 is in the normally open mode, the nozzle system has an oligonucleotide synthesis mode, and when the first solenoid valve 2 is in the normally closed mode and the second solenoid valve 4 is in the normally open mode, the nozzle system has a cleaning mode, so that a set of nozzle systems can synthesize oligonucleotides or clean the nozzle 1 according to needs, and there is no need to connect external cleaning equipment, disassemble the nozzle 1 or clean it manually when the nozzle system needs to be cleaned, which greatly improves the convenience of cleaning the nozzle 1.

[0044] The inkjet pressure line 6 in the present embodiment is suitable for circulating positive pressure gas, and the cleaning pressure line 7 is suitable for circulating positive pressure gas. By arranging the circulating positive pressure gas in the inkjet pressure line 6, the positive pressure gas can drive the synthesis reagent to flow toward the nozzle 1 in the synthetic oligonucleotide mode, and by arranging the circulating positive pressure gas in the cleaning pressure line 7, the positive pressure gas can drive the cleaning reagent to flow toward the nozzle 1 in the cleaning mode, which is convenient for driving and can prevent backflow. As a convertible embodiment, it is also possible that a driving pump is arranged on the inkjet pressure line 6 to drive the synthesis reagent in the synthetic oligonucleotide mode. As a convertible embodiment, it is also possible that a driving pump is arranged on the cleaning pressure line 7 to drive the cleaning reagent in the cleaning mode.

[0045] Specifically, the first solenoid valve 2 and the second solenoid valve 4 in this embodiment are two-position three-way solenoid valves, which are suitable for converting the normally open mode to the normally closed mode after being energized. By setting the first solenoid valve 2 and the second solenoid valve 4 as two-position three-way solenoid valves, the two-position three-way solenoid valves can be switched between the normally open mode and the normally closed mode when they are energized and not energized, and the structure is relatively simple. As a convertible implementation, the first solenoid valve 2 and the second solenoid valve 4 can also be other forms of solenoid valves, and no excessive restrictions are made here.

[0046] Among them, the two-position three-way solenoid valve can be selected from the chemical-resistant Baode 00137779 model or the SMC-LVM series two-position three-way solenoid valve, or other models, without too many restrictions here.

[0047] like Figure 1 As shown, the nozzle 1 in this embodiment is a multi-color nozzle, and the first solenoid valve 2 and the synthetic reagent container 3 are respectively provided with a plurality. Specifically, the nozzle 1 in this embodiment is a four-color nozzle, and the synthetic reagent container 3 is provided with five, and the corresponding synthetic reagents are A (Adenine), T (Thymine), C (Cytosine), G (Guanine) and ACT (Activator), and similarly, the first solenoid valve 2 connected to the synthetic reagent container 3 is also set to five. As a convertible embodiment, it is also possible that the nozzle 1 is a two-color nozzle, and the synthetic reagent container 3 is provided with two, or the nozzle 1 is a single-color nozzle, and the synthetic reagent container 3 is provided with one.

[0048] In the present embodiment, only one nozzle 1 is provided. Of course, in other embodiments, multiple nozzles 1 may be provided, and multiple nozzles 1 may be arranged in parallel to achieve cleaning or oligonucleotide synthesis of multiple nozzles 1 at the same time.

[0049] like Figure 1As shown, the other end of the second normally closed circuit in this embodiment is connected to the blowing pressure pipeline 8, and the blowing pressure pipeline 8 is suitable for blowing air into the nozzle 1 in the blowing mode; the first electromagnetic valve 2 is in the normally closed mode, and the second electromagnetic valve 4 is in the normally closed mode, so that the nozzle system has the blowing mode. By setting the blowing pressure pipeline 8, the nozzle system can have the blowing mode, so that the blowing mode is first run after the oligonucleotide synthesis mode or the cleaning mode, so that the residual reagents in the pipeline and the nozzle 1 are cleaned before cleaning or synthesizing oligonucleotides, thereby preventing waste of reagents.

[0050] Of course, in other embodiments, the other end of the second normally closed circuit may be connected to the atmosphere, and the nozzle system may not be set to the blowing mode. Instead, when the nozzle 1 needs to be cleaned after the oligonucleotide synthesis mode, the cleaning mode is directly started to clean the nozzle 1. After the cleaning mode, since the cleaning reagent will remain in the pipeline, it is necessary to run more synthesis reagents to empty the residual cleaning reagents in the pipeline before the oligonucleotide synthesis mode is performed, which will waste some synthesis reagents.

[0051] Similar to the inkjet pressure pipeline 6 and the cleaning pressure pipeline 7, the air blowing pressure pipeline 8 is suitable for flowing positive pressure gas.

[0052] In order to facilitate the distribution of synthesis reagents and cleaning reagents to multiple first solenoid valves 2, a first diversion structure 9 is provided between the synthesis reagent container 3 and the inkjet pressure pipeline 6 in this embodiment, and a second diversion structure 10 is provided between the second solenoid valve 4 and the first solenoid valve 2.

[0053] Among them, the first diversion structure 9 is a gas diversion row, which is suitable for diverting the positive pressure gas in the inkjet pressure pipeline 6 to the synthetic reagent container 3; the second diversion structure 10 can divert the cleaning reagent in the cleaning mode and divert the blowing air in the blowing mode.

[0054] The nozzle system in this embodiment includes: a control system, connected to the first solenoid valve 2 and the second solenoid valve 4, suitable for controlling the first solenoid valve 2 and the second solenoid valve 4 to be in a normally closed mode or a normally open mode. By setting the control system, the first solenoid valve 2 and the second solenoid valve 4 can be automatically powered on or off, and the synthetic oligonucleotide mode, cleaning mode and blowing mode of the nozzle system can be automatically switched, so that the operation of the nozzle system is more automated.

[0055] Among them, a third solenoid valve can also be set on the inkjet pressure pipeline 6, the cleaning pressure pipeline 7 and the blowing pressure pipeline 8 respectively, and the control system is connected to the third solenoid valve, which is suitable for controlling the automatic opening of the inkjet pressure pipeline 6, the cleaning pressure pipeline 7 and the blowing pressure pipeline 8.

[0056] In order to facilitate pressure control, pressure sensors can also be respectively provided on the inkjet pressure pipeline 6, the cleaning pressure pipeline 7 and the air blowing pressure pipeline 8. The pressure sensors are connected to the control system and are suitable for automatically adjusting and controlling the pressure.

[0057] In one embodiment, a one-way valve is provided on the connecting pipeline. By providing a one-way valve on the connecting pipeline, the backflow of the reagent can be prevented, and the smooth flow of the reagent is ensured to achieve the normal operation of the oligonucleotide mode and the cleaning mode. As a convertible embodiment, it is also possible that no one-way valve is provided on the connecting pipeline, but only positive pressure gas is used to drive the synthesis reagent or the cleaning reagent to flow.

[0058] The cleaning agent in this embodiment is ACN (Acetonitrile). As a changeable embodiment, the cleaning agent may also be PC (Propylene carbonate).

[0059] The connecting pipeline in this embodiment can be selected from 1 / 8 or 1 / 16 Teflon or PEEK material pipelines, or pipelines made of other materials, and no excessive restrictions are made here.

[0060] The nozzle system for oligonucleotide synthesis in this embodiment, when used in the oligonucleotide synthesis mode, the first solenoid valve 2 and the second solenoid valve 4 are in a non-energized state, the first solenoid valve 2 is in a normally open mode, and the synthesis reagent enters the nozzle 1 through the normally open path of the first solenoid valve 2 to achieve normal printing. When cleaning is required after printing for a period of time, the first solenoid valve 2 and the second solenoid valve 4 are both energized, the first solenoid valve 2 and the second solenoid valve 4 are both in a normally closed mode, and the air pressure pipeline 8 blows air to the nozzle 1 to blow out all the residual synthesis reagents in the pipeline, and then the first solenoid valve 2 is energized, the second solenoid valve 4 is de-energized, the first solenoid valve 2 is in a normally closed mode, and the second solenoid valve 4 is in a normally open mode, and the cleaning reagent enters the nozzle 1 through the normally open path of the second solenoid valve 4 and the normally closed path of the first solenoid valve 2 to achieve cleaning. After the nozzle 1 is cleaned, the first solenoid valve 2 and the second solenoid valve 4 can be energized, the first solenoid valve 2 and the second solenoid valve 4 are both in normally closed mode, and the air pressure pipeline 8 blows air to the nozzle 1 to blow out all the residual cleaning reagents in the pipeline, and then the synthetic oligonucleotide mode is turned on.

[0061] Since there are multiple first solenoid valves 2 in this embodiment, in the cleaning mode, multiple routes can be selected for cleaning at the same time. At this time, multiple first solenoid valves 2 are powered on and working, and the working efficiency is relatively high. Alternatively, only a single route can be selected for cleaning. At this time, any first solenoid valve 2 can be powered on. After one first solenoid valve 2 is closed after cleaning, another first solenoid valve 2 is opened until all cleaning is completed. This can avoid the problem of uneven liquid distribution when cleaning multiple routes at the same time, but it takes a long time.

[0062] Although the embodiments of the present invention are described in conjunction with the accompanying drawings, those skilled in the art may make various modifications and variations without departing from the spirit and scope of the present invention, and such modifications and variations are all within the scope defined by the appended claims.

Claims

1. A nozzle system for oligonucleotide synthesis, characterized in that: include: Nozzle (1); A plurality of first solenoid valves (2), wherein the first solenoid valves (2) comprise a first normally closed circuit, a first normally open circuit and a first outlet, wherein one end of the first normally closed circuit is suitable for being connected to the spray head (1) via the first outlet through a connecting pipeline, so that the first solenoid valve (2) has a normally closed mode, or one end of the first normally open circuit is suitable for being connected to the spray head (1) via the first outlet through a connecting pipeline, so that the first solenoid valve (2) has a normally open mode; A plurality of synthesis reagent containers (3), one end of which is connected to the other end of the first normally open circuit, and the other end of which is connected to an inkjet pressure pipeline (6), wherein the synthesis reagent containers (3) are arranged in a one-to-one correspondence with the first solenoid valve (2), the synthesis reagent containers (3) are suitable for accommodating synthesis reagents, and the inkjet pressure pipeline (6) is suitable for driving the synthesis reagents to flow toward the nozzle (1) in the oligonucleotide synthesis mode; a second solenoid valve (4), the second solenoid valve (4) comprising a second normally closed circuit, a second normally open circuit and a second outlet, one end of the second normally closed circuit being suitable for being connected to the other end of the first normally closed circuit via the second outlet, so that the second solenoid valve (4) has a normally closed mode, or one end of the second normally open circuit being suitable for being connected to the other end of the first normally closed circuit via the second outlet, so that the second solenoid valve (4) has a normally open mode; a cleaning reagent container (5), one end of which is connected to the other end of the second normally open circuit, and the other end of which is connected to a cleaning pressure pipeline (7); the cleaning reagent container (5) is suitable for containing a cleaning reagent, and the cleaning pressure pipeline (7) is suitable for driving the cleaning reagent to flow toward the nozzle (1) in a cleaning mode; The first solenoid valve (2) is in the normally open mode so that the nozzle system has the synthetic oligonucleotide mode; the first solenoid valve (2) is in the normally closed mode, and the second solenoid valve (4) is in the normally open mode so that the nozzle system has the cleaning mode.

2. The nozzle system for oligonucleotide synthesis according to claim 1, characterized in that: The inkjet pressure pipeline (6) is suitable for circulating positive pressure gas, and the cleaning pressure pipeline (7) is suitable for circulating positive pressure gas.

3. The nozzle system for oligonucleotide synthesis according to claim 1, characterized in that: The first solenoid valve (2) and the second solenoid valve (4) are two-position three-way solenoid valves, and the two-position three-way solenoid valves are suitable for converting a normally open mode to a normally closed mode after being energized.

4. The nozzle system for oligonucleotide synthesis according to any one of claims 1 to 3, characterized in that: The nozzle (1) is a multi-color nozzle (1), and the first solenoid valve (2) and the synthetic reagent container (3) are each provided with a plurality.

5. The nozzle system for oligonucleotide synthesis according to claim 4, characterized in that: A first flow-dividing structure (9) is provided between the synthetic reagent container (3) and the inkjet pressure pipeline (6), and a second flow-dividing structure (10) is provided between the second solenoid valve (4) and the first solenoid valve (2).

6. The nozzle system for oligonucleotide synthesis according to claim 4, characterized in that: The nozzle (1) is a four-color nozzle, and the synthetic reagent containers (3) are provided with five, and the synthetic reagents corresponding to them are adenine, thymine, cytosine, guanine and an activator respectively.

7. The nozzle system for oligonucleotide synthesis according to any one of claims 1 to 3, characterized in that: The other end of the second normally closed circuit is connected to a blowing pressure pipeline (8), and the blowing pressure pipeline (8) is suitable for blowing air into the nozzle (1) in a blowing mode; The first solenoid valve (2) is in the normally closed mode, and the second solenoid valve (4) is in the normally closed mode, so that the spray head system has the blowing mode.

8. The nozzle system for oligonucleotide synthesis according to claim 7, characterized in that: The blowing pressure pipeline (8) is suitable for circulating positive pressure gas.

9. The nozzle system for oligonucleotide synthesis according to any one of claims 1 to 3, characterized in that: The nozzle system comprises: A control system is connected to the first solenoid valve (2) and the second solenoid valve (4), and is suitable for controlling the first solenoid valve (2) and the second solenoid valve (4) to be in the normally closed mode or the normally open mode.

10. The nozzle system for oligonucleotide synthesis according to any one of claims 1 to 3, characterized in that: A one-way valve is arranged on the connecting pipeline.

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