Limiting stopper for mild anesthesia of laboratory mice

Abstract

The utility model discloses a limiter for the mild anesthesia of laboratory mice, which comprises a protective cover, a bottom plate and a limiting hole arranged on the bottom plate, an operation window is arranged on the protective cover, and a limiting mechanism is arranged above the operation window and is used for limiting the mice. The experimental mouse is covered in the protective cover, the flexible clamp clamps the body part of the mouse, the tail part of the mouse is clamped in the limiting hole and compressed, the abdomen of the experimental mouse directly faces the operation window, puncture injection anesthesia can be conveniently carried out on the experimental mouse through the operation window, and the experimental mouse has an activity space in the protective cover, so that the experimental mouse is prevented from violently struggling due to body limitation; and the head of the anesthesia device is isolated by the upper end of the protective cover, so that an operator can be prevented from being bitten.

Description

Technical Field

[0001] The utility model relates to the technical field of conducting experiments using model organisms, in particular to a limiter used for mild anesthesia of experimental mice. Background Art

[0002] There are three commonly used methods of anesthesia for animals and mice in biological research: traditional inhalation anesthesia, isoflurane gas anesthesia and traditional injection anesthesia.

[0003] Although traditional inhalation anesthesia provides rapid anesthesia and postoperative recovery, it is difficult to control the anesthesia induction (concentration and time) of experimental mice, and it has a strong pungent odor, which can easily cause harm to the experimenters and is flammable and explosive.

[0004] Isoflurane gas anesthesia has faster anesthesia and awakening, the depth of anesthesia is easy to control, and the mortality rate and complications are low. However, isoflurane gas is volatile and can easily cause harm to experimenters.

[0005] The specific operation method of traditional injection anesthesia (chloral hydrate, sodium pentobarbital, etc.) is as follows: 1. A 1ml syringe is generally used for intraperitoneal injection of mice, with a No. 4 needle; 2. During intraperitoneal injection, hold the syringe in the right hand, grab the mouse's tail with the little finger and ring finger of the left hand, and grab the mouse's neck with the other three fingers to make the mouse's head face down, so that the organs in the abdominal cavity will naturally fall toward the chest to prevent the large intestine, small intestine and other organs from being damaged when the syringe is inserted. The needle should be inserted gently to prevent stabbing of abdominal organs; 3. During intraperitoneal injection, the needle travels a short distance under the abdominal skin, preferably from one side of the abdomen, through the midline of the abdomen, and then enters the abdominal cavity on the other side of the abdomen. After injecting the drug, slowly pull out the needle and rotate the needle slightly to prevent leakage. The defects of this anesthesia method are: 1. The operation process is complicated, and the requirements for experimental technicians are high. During the operation, the mice struggle violently, and the stimulated mice are easy to bite the operator; 2. The stimulated mice struggle, which increases the difficulty of puncturing the abdominal wall skin, and it is not easy to control, resulting in the possibility of drug injection into the abdominal organs. Utility Model Content

[0006] The technical problem to be solved by the utility model is to provide a limiter for mild anesthesia of experimental mice. The experimental mouse is covered in a protective cover, and the tail is stuck in the limit hole and pressed tightly. The abdomen of the experimental mouse is facing the operation window, which is convenient for puncture injection anesthesia through the operation window. In addition, the experimental mouse has room for movement in the protective cover, which prevents it from struggling violently due to physical restrictions, providing favorable conditions for the smooth progress of the anesthesia process. The head of the experimental mouse is isolated by the upper end of the protective cover, which can prevent the operator from being bitten.

[0007] In order to achieve the above-mentioned purpose, the technical solution adopted by the utility model is: a limiter for mild anesthesia of experimental mice, including a protective cover, a base plate and a limit hole opened on the base plate, an operating window is opened on the protective cover, and a limit mechanism is arranged above the operating window for limiting mice.

[0008] As a preferred technical solution of the utility model, the limiting mechanism includes a horizontally arranged flexible clamp, one end of which is provided with an incomplete gear, the incomplete gear is connected to the protective cover through a ring, a screw is sleeved in the ring, and the thread of the screw cooperates with the teeth of the incomplete gear.

[0009] As a preferred technical solution of the utility model, the flexible clip is arranged in an eight-shaped shape and includes clip one and clip two, clip one and clip two are both trapezoidal frames, the frame on the side close to clip one and clip two is a flexible rod, and the other frame is a rigid rod, and the two ends of the flexible rod are hinged to the rigid rod.

[0010] As a preferred technical solution of the utility model, the protective cover is a conical cylinder, the bottom plate is hinged to the bottom of the protective cover by a hinge, and the limiting hole is opened at the edge of the bottom plate.

[0011] As a preferred technical solution of the present utility model, the limiting hole is arranged on the opposite side of the hinge.

[0012] As a preferred technical solution of the utility model, the tip of the top of the protective cover is rounded and provided with a handle; a bait table is arranged inside the protective cover.

[0013] As a preferred technical solution of the utility model, the operating window is an annular window along the side wall of the protective cover, and railings are evenly arranged in the operating window, and the railings have the same inclination as the side wall of the protective cover.

[0014] The beneficial effects of adopting the above technical scheme are: the utility model covers the experimental mouse in the protective cover, the flexible clamp clamps the mouse body part, the tail is stuck in the limiting hole and pressed tightly, the abdomen of the experimental mouse is facing the operation window, and the operation window can be operated at any position in 360 degrees, which is convenient for puncture injection anesthesia through the operation window, and the experimental mouse has room for movement in the protective cover, which prevents it from struggling violently due to physical restrictions, providing favorable conditions for the smooth progress of the anesthesia process, and its head is isolated by the upper end of the protective cover to avoid biting the operator. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The utility model is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0016] Figure 1 It is a structural schematic diagram of the utility model.

[0017] Figure 2 yes Figure 1 Sectional view of AA.

[0018] Figure 3 It is a schematic diagram of the connection relationship of the limit mechanism.

[0019] Figure 4 yes Figure 1 Cross-sectional view of BB.

[0020] Figure 5 It is a schematic diagram of the position relationship of the limiting holes.

[0021] In the figure: 1, protective cover 2, bottom plate 3, limit hole 4, operation window 5, hinge 6, handle 7, bait platform 8, railing 9, flexible clip 10, incomplete gear 11, collar 12, screw 13, flexible rod 14, hard rod 15, fixing plate. DETAILED DESCRIPTION

[0022] The structure of a specific implementation of the utility model includes a protective cover 1, a bottom plate 2 and a limiting hole 3 opened on the bottom plate 2. An operating window 4 is opened on the protective cover 1, and a limiting mechanism is arranged above the operating window 4 for limiting mice.

[0023] The protective cover 1 is a conical cylinder, the bottom plate 2 is hinged to the bottom of the protective cover 1 by a hinge 5, and the limit hole 3 is provided at the edge of the bottom plate 2. The protective cover 1 is preferably in a conical shape, and may also be in a quadrangular pyramid shape. When the protective cover 1 is in a conical shape, the bottom plate 2 is circular. According to the body size of the experimental mouse, the height of the protective cover 1 is 8-10 cm, the diameter of the bottom plate 2 is 3-4 cm, and the lower and upper edges of the operating window 4 are 1.5 cm and 3 cm away from the bottom of the protective cover, respectively. This size can ensure that the mouse head cannot be folded back to the operating window 4.

[0024] The limiting mechanism includes a horizontally arranged flexible clamp 9, one end of which is provided with an incomplete gear 10, which is connected to the protective cover 1 through a collar 11, and a screw 12 is sleeved in the collar 11, and the threads of the screw 12 match the teeth of the incomplete gear 10.

[0025] The flexible clip 9 is arranged in an eight-shaped shape and includes a clip piece 1 and a clip piece 2, both of which are trapezoidal frames. Figure 1 The projections of the middle clips 1 and 2 on the AA section are trapezoidal, the frame on the side close to the clips 1 and 2 is a flexible rod 13, and the other frames are rigid rods 14, and both ends of the flexible rod 13 are hinged to the rigid rod 14.

[0026] A hole for accommodating a collar 11 is provided on the protective cover 1. The collar 11 is arranged in the hole and passes through the protective cover 1. The outer wall of the collar 11 is fixedly connected to the inner wall of the hole. The inner wall of the collar 11 is provided with a thread matching with the screw 12. Four fixing plates 15 are horizontally arranged at the end of the collar 11 located inside the protective cover 1. The four fixing plates 15 are symmetrically arranged in pairs and divided into two groups of fixing plates 15. The two groups of fixing plates 15 are arranged on the opposite sides of the collar 11. A pin is arranged through the center position of the fixing plate 15, and the two ends of the pin are fixedly connected to the fixing plate 15.

[0027] The incomplete gear 10 is fixedly connected to the hard rod closest to the first and second clips. The incomplete gear 10 is horizontally arranged and located between a group of fixed plates 15 arranged up and down. The pin passes through the incomplete gear 10 and is rotatably connected to the incomplete gear 10. The teeth of the incomplete gear 10 are engaged with the threads of the screw 12. The rotation of the screw 12 drives the incomplete gear 10 to rotate with the pin as the center, thereby realizing the opening and closing of the flexible clamp 9. The flexible clamp 9 can both limit the body shape of the mouse and avoid pinching the mouse.

[0028] The limiting hole 3 is arranged on the opposite side of the hinge 5. The bottom edge of the protective cover 1 is covered with a rubber pad. The rubber pad presses the tail of the experimental mouse, which not only increases the friction force but also relieves the pain of the tail.

[0029] The tip of the top of the protective cover 1 is rounded and provided with a handle 6; a bait table 7 is arranged inside the protective cover 1, the bait table 7 is inclined, and a passage connected to the outside is opened, and the passage is convenient for replenishing food bait to the bait table 7. The handle 6 is convenient for holding when opening or closing the protective cover 1, and the bait table 7 is placed with food bait to attract the attention of the experimental mice.

[0030] The operation window 4 is an annular window along the side wall of the protection cover 1 . Railings 8 are evenly arranged in the operation window 4 . The railings 8 have the same inclination as the side wall of the protection cover 1 .

[0031] When in use, first open the protective cover 1 and the bottom plate 2, pull the tail of the experimental mouse, and use the physiological characteristics of the experimental mouse to make the experimental mouse drill into the protective cover 1. After drilling into the protective cover 1, its tail is stuck in the limiting hole 3, and the screw 12 is turned to drive the incomplete gear 10 to rotate, so that the flexible clamp 9 clamps the mouse body, and then the protective cover 1 and the bottom plate 2 are closed and the tail of the experimental mouse is pressed by the edge of the bottom of the protective cover 1. At this time, the body of the experimental mouse is stored in the space enclosed by the protective cover 1 and the bottom plate 2, and the light on the head is dim and narrow. At the same time, the bait on the bait table 7 distracts its attention and prevents it from struggling violently, so that the puncture injection anesthesia work can be carried out smoothly through the operating window 4, and it also avoids biting the operator.

[0032] For easy operation, the structure also includes a buckle for fixing the protective cover 1 and the base plate 2 in a closed state.

[0033] The above description is only proposed as an implementable technical solution of the present invention, and is not intended to be a single limitation on the technical solution itself.

Claims

1. A stopper for mild anesthesia of experimental mice, characterized in that: It includes a protective cover, a base plate and a limiting hole opened on the base plate, an operating window is opened on the protective cover, and a limiting mechanism is arranged above the operating window for limiting mice, the limiting mechanism includes a horizontally arranged flexible clip, one end of the flexible clip is provided with an incomplete gear, the incomplete gear is connected to the protective cover through a collar, a screw is sleeved in the collar, the thread of the screw matches with the teeth of the incomplete gear, the flexible clip is arranged in an eight-shaped shape and includes a clip piece 1 and a clip piece 2, both the clip piece 1 and the clip piece 2 are trapezoidal frames, the frame on the side close to the clip piece 1 and the clip piece 2 is a flexible rod, and the other frames are rigid rods, and both ends of the flexible rod are hinged to the rigid rod.

2. The limiter for mild anesthesia of experimental mice according to claim 1, characterized in that: The protective cover is a conical cylinder, the bottom plate is hinged to the bottom of the protective cover through a hinge, and the limiting hole is arranged on the edge of the bottom plate.

3. The limiter for mild anesthesia of experimental mice according to claim 2, characterized in that: The limiting hole is arranged on the opposite side of the hinge.

4. The limiter for mild anesthesia of experimental mice according to claim 1, characterized in that: The tip of the top of the protective cover is rounded and provided with a handle; a bait table is arranged inside the protective cover.

5. The stopper for mild anesthesia of experimental mice according to claim 1, characterized in that: The operating window is an annular window along the side wall of the protection cover. Railings are evenly arranged in the operating window, and the railings have the same inclination as the side wall of the protection cover.

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