A chromatography column high-position storage tank liquid level prompting device and column chromatography system

Abstract

The utility model provides a liquid level indication device for a high-position storage tank of a chromatography column and a column chromatography system, and relates to the field of chromatography technology pharmaceutical equipment. The column chromatography system includes a chromatography column, a high-position storage tank and an indication device; the liquid level indication device for the high-position storage tank of a chromatography column includes: an explosion-proof housing, which is sealed inside and has a step structure and a step groove on the outer wall, and a plurality of photosensitive elements of different heights are embedded on the inner wall of the step groove; a transparent step tube, which is embedded in the step groove and adapted to its shape, and a connecting tube for connecting to the object container is arranged at the bottom of the transparent step tube; an alarm component and a display component, which are both embedded on the outer wall of the explosion-proof housing and have a first protection mechanism and a second protection mechanism respectively; and a control component, which is arranged in the explosion-proof housing and is electrically connected to the photosensitive element, the alarm component and the display component; the utility model can improve the service life of the filler, and has a simple structure and saves materials.

Description

Technical Field

[0001] The utility model relates to the field of chromatography technology pharmaceutical equipment, in particular to a chromatography column high-position storage tank liquid level prompting device and a column chromatography system. Background Art

[0002] Chromatography technology is a commonly used separation and purification method in the traditional Chinese medicine pharmaceutical industry. Among the chromatography columns commonly used in chromatography technology, chromatography fillers are the most important type of consumables. According to the data from the Prospective Industry Research Institute, the current global chromatography filler market size will be close to US$7 billion, among which the pharmaceutical industry is the most important application field of chromatography fillers. With the development of China's pharmaceutical industry, the demand for chromatography fillers is increasing day by day. At the same time, chromatography fillers, as key consumables for separation and purification, account for most of the downstream production costs. Based on the dual considerations of regulations and costs, various pharmaceutical companies are conducting research on giving full play to the use of fillers and extending the service life of fillers without affecting product quality and meeting product yields.

[0003] Among them, the liquid level in the chromatography column is an important factor affecting the service life and use effect of the filler. If the liquid level is too low, air may enter the chromatography column, forming bubbles or foam, which will affect the efficiency and purity of the chromatography process; at the same time, if the liquid level is too low, the filler may be exposed to the air, causing the filler to dry, affecting its performance and life; in addition, too low a liquid level will also lead to reduced column efficiency, sample dilution, column bed compression deformation, increased dead volume and other effects. In order to ensure the efficiency of the chromatography process and the service life and use effect of the filler, the appropriate liquid level should be maintained according to the operating requirements of the chromatography column. If the liquid level is found to be too low, measures should be taken to adjust the liquid level.

[0004] Existing chromatography columns usually store liquid by setting a high-level storage tank at the inlet end of the raw liquid to prevent the raw liquid flow rate from changing and causing the liquid level in the chromatography column to be too low. However, when the liquid level in the high-level storage tank is too low, it will not be able to supply enough liquid to maintain the liquid level in the chromatography column. Due to the production environment restrictions of pharmaceutical factories, the explosion-proof requirements for electronic components are relatively high. At present, the control of the liquid level in the high-level storage tank in production is generally carried out by manual inspection and observation. There is no automated low liquid level alarm device, which leads to the frequent occurrence of low liquid level in the chromatography column, which seriously affects the service life of the filler. Utility Model Content

[0005] The utility model aims to solve the problem that the production environment of a Chinese medicine factory in the prior art has high explosion-proof requirements for electronic components, the control of the liquid level in a high-level storage tank generally uses manual inspection and observation, and there is no automated low liquid level alarm device, resulting in the phenomenon of low liquid level in a chromatography column occurring from time to time, which seriously affects the service life of the filler. The utility model provides a chromatography column high-level storage tank liquid level prompt device and a column chromatography system that can automatically monitor the liquid level and give an alarm.

[0006] The technical solution adopted by the utility model is:

[0007] A liquid level prompting device for a chromatography column high-position storage tank, comprising:

[0008] The explosion-proof housing is sealed internally, and a step structure is arranged on the outer wall thereof, a step groove is arranged on the step structure, and a plurality of photosensitive elements of different heights are embedded in the inner wall of the step groove;

[0009] A transparent step tube is embedded in the step groove and adapted to its shape, and the top of the transparent step tube is sealed, and a connecting tube connected to the target container is provided at the bottom of the transparent step tube;

[0010] The alarm component and the display component are both embedded in the outer wall of the explosion-proof housing and have a first protection mechanism and a second protection mechanism respectively; and

[0011] A control component is arranged in the explosion-proof housing and is electrically connected to the photosensitive element, the alarm component and the display component. The control component can receive the photosensitive element signal, determine whether to send an alarm signal to the alarm component, and send different display signals to the display component.

[0012] Furthermore, the alarm component at least has:

[0013] An audible and visual alarm, embedded on the outer wall of the explosion-proof housing;

[0014] Wherein, the first protection mechanism is an explosion-proof grille, and the explosion-proof grille is arranged to surround the outside of the sound and light alarm.

[0015] Furthermore, the alarm component at least has:

[0016] a loudspeaker, embedded in the outer wall of the explosion-proof housing, wherein a diaphragm is arranged in the loudspeaker; and

[0017] A sound generating unit connected to one end of the loudspeaker extending into the explosion-proof housing;

[0018] Wherein, the first protection mechanism is an explosion-proof baffle, and the explosion-proof baffle is arranged in the loudspeaker and located outside the diaphragm.

[0019] Furthermore, the sound-emitting unit is a buzzer.

[0020] Furthermore, the sound-emitting unit is a speaker.

[0021] Furthermore, the display component at least has:

[0022] A display, embedded on the outer wall of the explosion-proof housing;

[0023] Wherein, the second protection mechanism is a transparent protective cover, and the transparent protective cover is arranged to surround the outside of the display.

[0024] Furthermore, the second protection mechanism is a transparent baffle, and is embedded on the outer wall of the explosion-proof housing, and the display assembly at least has:

[0025] A projector is arranged in the explosion-proof housing, and the projection lens thereof corresponds to the position of the transparent baffle.

[0026] Furthermore, the photosensitive element is a photosensitive receiver.

[0027] Furthermore, a circulating fan is arranged inside the explosion-proof housing, and a ventilation duct is arranged on the explosion-proof housing to connect to the outside of the factory building.

[0028] A column chromatography system, characterized in that it comprises:

[0029] Chromatographic column with built-in filler;

[0030] A high-level storage tank is arranged above the chromatography column and is provided with a raw material liquid inlet and a liquid outlet connected to the chromatography column; and

[0031] The liquid level prompting device for the chromatography column high-position storage tank as described above has a connecting pipe that is in communication with the bottom of the high-position storage tank.

[0032] The beneficial effects of the utility model are:

[0033] 1. The utility model uses a simple structure to convert the liquid level signal in the high-level storage tank into an electrical signal in the prompt device by setting a step structure, a photosensitive element and a transparent step pipe connected to the bottom of the high-level storage tank on the explosion-proof housing, thereby realizing automatic monitoring of the liquid level and alarming. At the same time, the electronic components are separated from the external space, avoiding the explosion risk of the peripheral with an electronic liquid level gauge, thereby solving the problem that the explosion-proof requirements of the production environment of the traditional Chinese medicine factory for electronic components conflict with the automated liquid level alarm device in the prior art, resulting in the liquid level in the chromatography column being too low and affecting the service life of the filler;

[0034] 2. The utility model also integrates the main circuit components of the prompt device into an explosion-proof shell with explosion-proof function, and provides explosion-proof protection for the electronic components in the prompt device through the coordinated setting of an explosion-proof shell and a first protection mechanism and a second protection mechanism, thereby eliminating the need to separately set explosion-proof structures for multiple dispersed components, thus having the advantages of saving materials and reducing workload, and also being more convenient for unified maintenance. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0036] Figure 1 A three-dimensional schematic diagram of a column chromatography system according to an embodiment of the utility model;

[0037] Figure 2 It is a three-dimensional schematic diagram of an explosion-proof housing according to an embodiment of the utility model;

[0038] Figure 3 It is a three-dimensional schematic diagram of a transparent step tube according to an embodiment of the utility model;

[0039] Figure 4 This is a diagram of the internal structure of the prompting device according to an embodiment of the utility model;

[0040] Figure 5 This is an internal structure diagram of a prompting device according to a second embodiment of the utility model;

[0041] Figure 6 This is a diagram of the internal structure of the prompting device according to the third embodiment of the present utility model.

[0042] Reference numerals: 100 - explosion-proof housing, 110 - stepped structure, 113 - stepped groove, 130 - photosensitive element;

[0043] 200-transparent step tube, 220-connecting tube;

[0044] 300-alarm component, 310-loudspeaker, 312-diaphragm, 320-sounding unit, 330-sound and light alarm, 350-first protection mechanism, 352-explosion-proof baffle, 354-explosion-proof grille;

[0045] 400 - display assembly, 410 - display, 420 - projector, 422 - projection lens, 450 - second protection mechanism, 452 - transparent protective cover, 454 - transparent baffle;

[0046] 500-control components;

[0047] 620-circulation fan, 640-ventilation duct;

[0048] 700-chromatography column;

[0049] 800-high position storage tank, 810-raw liquid inlet, 820-liquid outlet. DETAILED DESCRIPTION

[0050] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0051] The disclosure below provides many different embodiments or examples to implement different structures of the present invention. In order to simplify the disclosure of the present invention, the components and settings of specific examples are described below. Of course, they are only examples and are not intended to limit the present invention.

[0052] The embodiments of the utility model are described in detail below with reference to the accompanying drawings.

[0053] See also Figure 1-Figure 4 The first embodiment provides a column chromatography system for separation and purification of Chinese medicine raw material liquid. The column chromatography system mainly includes: a chromatography column 700, a high-level storage tank 800, etc., and also includes a chromatography column high-level storage tank liquid level prompt device.

[0054] like Figure 1 As shown in the figure, the chromatography column 700 is located on a low-level platform, and the built-in filler is used for separation and purification of the raw material liquid of traditional Chinese medicine. The high-level storage tank 800 is arranged on the high-level platform above the chromatography column 700, and is used to maintain the liquid level in the chromatography column 700. The high-level storage tank 800 is roughly cylindrical in shape, and a raw material liquid inlet 810 is arranged on its top, and a liquid outlet 820 connected to the chromatography column 700 is arranged at its bottom, and the bottom of the high-level storage tank 800 is also connected to a prompt device, which is convenient for it to automatically monitor the liquid level and alarm.

[0055] like Figure 1 As shown in the figure, a chromatography column high-level storage tank liquid level prompt device of this embodiment is arranged on a high-level platform and is located on one side of the high-level storage tank 800. The prompt device is used to automatically monitor the liquid level and automatically alarm when the liquid level is low. The prompt device mainly includes: an explosion-proof shell 100, a transparent step pipe 200, an alarm component 300, a display component 400 and a control component 500, etc.

[0056] like Figure 1 , Figure 2As shown in , the explosion-proof shell 100 is roughly in the shape of a rectangular parallelepiped. The explosion-proof shell 100 is made of high-strength metal material and is internally sealed for explosion-proof protection of the prompt device of this embodiment. A step structure 110 is also provided on the outer wall of the explosion-proof shell 100. The step structure 110 is a part of the explosion-proof shell 100, and the internal cavities of the two are connected. One side of the step structure 110 is in a step shape, and a step groove 113 is provided on the stepped side. The step groove 113 is a groove whose shape is adapted to the stepped side, and is arranged in the middle of the step groove 113 from top to bottom, and a number of photosensitive elements 130 of different heights are embedded on the inner wall of the step groove 113. The photosensitive element 130 in this embodiment can use a photosensitive receiver or directly use a photoresistor, and the photosensitive elements 130 are evenly distributed on the step surface of each level. As shown Figure 1 As shown, the stepped structure 110 in this embodiment has four steps, but other numbers of steps may be provided in one or more embodiments. The design of the steps of the stepped structure 110 avoids photosensitive elements 130 of different heights blocking each other's reception of visible light.

[0057] like Figure 1 , Figure 3 As shown in , the transparent step tube 200 is a transparent glass tube, which is embedded in the step groove 113 and adapted to its shape, so it will cover the photosensitive element 130 embedded in the inner wall of the step groove 113. At the same time, the top of the transparent step tube 200 is sealed, and the bottom of the transparent step tube 200 is provided with a connecting pipe 220 connected to the high-level storage tank 800. Therefore, when the liquid level of the Chinese medicine raw material liquid in the high-level storage tank 800 is low, the liquid level in the transparent step tube 200 can change synchronously with it; and the Chinese medicine raw material liquid is mainly a dark brown solution. Since brown is usually produced by absorbing a large amount of light in the visible spectrum, especially absorbing light in the blue and green bands, the transmittance of the dark brown solution is usually low. The liquid level of the Chinese medicine raw material liquid in the transparent step tube 200 will directly affect the reception of visible light, that is, the light in the factory by the photosensitive element 130 covered below it.

[0058] like Figure 2 , Figure 4 As shown in the figure, the alarm assembly 300 is embedded in the outer wall of the explosion-proof housing 100 for low liquid level alarm prompt, and a first protection mechanism 350 is provided to perform explosion-proof treatment on the alarm assembly 300. In this embodiment, the alarm assembly 300 mainly includes an audible and visual alarm 330 embedded in the outer wall of the explosion-proof housing 100, and the first protection mechanism 350 is mainly composed of an explosion-proof grille 354, which is surrounded and arranged outside the audible and visual alarm 330.

[0059] like Figure 2 , Figure 4As shown in , the display assembly 400 is embedded on the outer wall of the explosion-proof housing 100, and is used for liquid level display, so that the user can observe and know the liquid level in the high-level storage tank 800, and a second protection mechanism 450 is provided to perform explosion-proof treatment on the display assembly 400. In this embodiment, the display assembly 400 mainly includes a rectangular display 410 embedded on the outer wall of the explosion-proof housing 100, and the first protection mechanism 350 is mainly composed of a rectangular shell-shaped transparent protective cover 452, which is made of transparent plastic material and is surrounded and arranged on the outside of the display 410 to separate the display 410 from the external space.

[0060] like Figure 4 As shown in the figure, the control component 500 is a PLC controller. The control component 500 is arranged in the explosion-proof housing 100, and is electrically connected to the photosensitive element 130, the alarm component 300 and the display component 400. The control component 500 can receive the signal of the photosensitive element 130, and determine whether to send an alarm signal to the alarm component 300, and send different display signals to the display component 400.

[0061] A specific implementation of this embodiment is:

[0062] When the column chromatography system is working, the prompt device is kept in the open state synchronously. When the liquid level of the Chinese medicine raw material liquid in the high-level storage tank 800 is higher than the upper end of the transparent step tube 200, the liquid level in the transparent step tube 200 is close to the top, and the dark brown Chinese medicine raw material liquid has low light transmittance, so that the photosensitive elements 130 below are all in a dark resistance state, and the electrical signal fed back to the control component 500 corresponds to the normal liquid level, and the liquid level "high" is displayed on the display 410; when the liquid level in the high-level storage tank 800 decreases, the liquid level in the transparent step tube 200 decreases synchronously, and the photosensitive elements 130 below begin to change from a dark resistance state to a bright resistance state from top to bottom, and the electrical signal fed back to the control component 500 corresponds to different liquid levels in turn, which are displayed on the display 410. When the user observes that the liquid level interval is decreasing in different intervals, he can adjust the operation of the column chromatography system in time to avoid the liquid level being too low; when the liquid level in the high-level storage tank 800 is too low, the liquid level in the transparent step tube 200 decreases synchronously, and the number of photosensitive elements 130 below that become bright resistors reaches a certain number, and the electrical signal fed back to the control component 500 corresponds to the alarm threshold, and the liquid level is displayed as "too low" on the display 410. At the same time, an alarm signal is sent to the alarm component 300, and the sound and light alarm 330 is activated to prompt the user to stop or adjust the column chromatography system in time to avoid the long-term low liquid level affecting the service life of the filler in the chromatography column 700.

[0063] In this embodiment, the prompt device of the column chromatography system is equipped with a step structure 110 on the explosion-proof shell 100, a photosensitive element 130 and a transparent step tube 200 connected to the bottom of the high-level storage tank 800. It uses a simple structure to convert the liquid level signal in the high-level storage tank 800 into an electrical signal in the prompt device, thereby realizing automatic monitoring of the liquid level and alarming. At the same time, the electronic components are separated from the external space, avoiding the risk of explosion of the peripheral device with an electronic liquid level gauge, thereby solving the problem that the explosion-proof requirements of the production environment of the traditional Chinese medicine factory for electronic components conflict with the automated liquid level alarm device, resulting in the liquid level in the chromatography column being too low and affecting the service life of the filler.

[0064] At the same time, in this embodiment, the main circuit components of the prompt device are integrated inside an explosion-proof shell 100 with explosion-proof function. Through the coordinated setting of an explosion-proof shell 100 and a first protection mechanism 350 and a second protection mechanism 450, the electronic components in the prompt device are explosion-proof protected, so that there is no need to set explosion-proof structures for each scattered component separately, which has the advantages of saving materials and reducing workload, and is also convenient for unified maintenance.

[0065] In addition, the photosensitive element 130 in this embodiment uses a photoresistor or a photosensitive receiver, such as a photodiode, a phototransistor, a phototransistor, etc., which usually does not generate a lot of heat under normal working conditions, is not easy to generate heat, and is usually not easy to generate electric sparks, and is safer to use in an environment that requires explosion-proof. At the same time, the photosensitive element 130 in this embodiment uses the light of the lighting source that has been explosion-proofed in the factory, and there is no need to add an additional light source and corresponding explosion-proof equipment.

[0066] Preferably, in this embodiment, a circulating fan 620 may be provided inside the explosion-proof housing 100, and a ventilation duct 640 may be provided on the explosion-proof housing 100 to connect to the outside of the pharmaceutical factory for heat dissipation to avoid overheating of electrical components inside the prompt device.

[0067] A second embodiment is provided below.

[0068] See also Figure 5The second embodiment adopts another alarm component 300 on the basis of the above embodiment. The alarm component 300 in the second embodiment mainly includes a loudspeaker 310, which is roughly in the shape of a hollow truncated cone and is embedded in the outer wall of the explosion-proof shell 100. The smaller opening end extends into the interior of the explosion-proof shell 100. A diaphragm 312 is arranged in the loudspeaker 310. In addition, a sound unit 320 connected to the end of the loudspeaker 310 extending into the explosion-proof shell 100 is also provided. The sound unit 320 in this embodiment can be a buzzer or a sound. At the same time, the first protection mechanism 350 in the second embodiment is an explosion-proof baffle 352, which is arranged in the loudspeaker 310 and located on the outside of the diaphragm 312 to prevent the high-frequency vibration of the diaphragm 312 from contacting the external space.

[0069] In the second embodiment, the liquid level indication device of the chromatography column high-position storage tank separates the inner and outer spaces of the explosion-proof shell 100 by setting a loudspeaker 310 and an explosion-proof baffle plate 352, and the explosion-proof effect is better than the explosion-proof grille 354 in the first embodiment in combination with the sound and light alarm 330. However, the advantage of the explosion-proof grille 354 in combination with the sound and light alarm 330 is that it can provide prompts by both sound and light perception, and the alarm prompt is more effective.

[0070] A third embodiment is provided below.

[0071] See also Figure 6 The third embodiment adopts another display assembly 400 based on the above embodiment, and the second protection mechanism 450 is a transparent baffle 454 embedded on the outer wall of the explosion-proof housing 100.

[0072] In the third embodiment, the alarm component 300 of the liquid level prompt device of the high-level storage tank of the chromatography column mainly includes a projector 420, which is arranged in the explosion-proof housing 100, and its projection lens 422 corresponds to the position of the transparent baffle 454. The liquid level information is projected to the outside, and the projection area can select a flat wall, platform surface or top wall in the pharmaceutical factory. The display component 400 of the third embodiment has a larger display area than the display component 400 of the first embodiment, but it is required that there is a flat projection area with a sufficient area in the pharmaceutical factory. Preferably, the projector 420 uses an LED cold light source to avoid overheating in the explosion-proof housing 100. In addition, the projector 420 can also be automatically turned off when the liquid level of the Chinese medicine raw material liquid in the high-level storage tank 800 is higher than the upper end of the transparent step tube 200 to avoid overheating caused by its long-term operation.

[0073] The above shows and describes the basic principle, main features and advantages of the utility model. Those skilled in the art should understand that the utility model is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the utility model and are not used to limit the utility model. Without departing from the spirit and scope of the utility model, the utility model may have various changes and improvements, which fall within the scope of the utility model to be protected. The scope of protection of the utility model is defined by the attached claims and their equivalents.

Claims

1. A liquid level prompting device for a chromatography column high-position storage tank, characterized in that: Include: An explosion-proof housing (100) is sealed internally, and a stepped structure (110) is provided on its outer wall. A stepped groove (113) is provided on the stepped structure (110), and a plurality of photosensitive elements (130) of different heights are embedded in the inner wall of the stepped groove (113); A transparent step tube (200) is embedded in the step groove (113) and matches the shape thereof, the top of the transparent step tube (200) is sealed, and a connecting tube (220) for communicating with a target container is provided at the bottom of the transparent step tube (200); The alarm component (300) and the display component (400) are both embedded on the outer wall of the explosion-proof housing (100), and respectively have a first protection mechanism (350) and a second protection mechanism (450); and A control component (500) is disposed in the explosion-proof housing (100) and is electrically connected to the photosensitive element (130), the alarm component (300) and the display component (400). The control component (500) is capable of receiving a signal from the photosensitive element (130), determining whether to send an alarm signal to the alarm component (300), and sending different display signals to the display component (400).

2. The chromatography column high-position storage tank liquid level prompting device according to claim 1, characterized in that: The alarm component (300) further comprises at least: An audible and visual alarm (330) embedded on the outer wall of the explosion-proof housing (100); The first protection mechanism (350) is an explosion-proof grille (354), and the explosion-proof grille (354) is arranged to surround the outside of the sound and light alarm (330).

3. The chromatography column high-position storage tank liquid level prompting device according to claim 1, characterized in that: The alarm component (300) further comprises at least: a loudspeaker (310) embedded in the outer wall of the explosion-proof housing (100), wherein a diaphragm (312) is disposed in the loudspeaker (310); and a sound-generating unit (320) connected to one end of the loudspeaker (310) extending into the explosion-proof housing (100); The first protection mechanism (350) is an explosion-proof blocking piece (352), and the explosion-proof blocking piece (352) is arranged in the loudspeaker (310) and is located outside the diaphragm (312).

4. The chromatography column high-position storage tank liquid level prompting device according to claim 3, characterized in that: The sound-generating unit (320) is a buzzer.

5. The chromatography column high-position storage tank liquid level prompting device according to claim 3, characterized in that: The sound-generating unit (320) is a speaker.

6. The chromatography column high-position storage tank liquid level prompting device according to claim 1, characterized in that: The display component (400) further comprises at least: a display (410) embedded on the outer wall of the explosion-proof housing (100); The second protection mechanism (450) is a transparent protective cover (452), and the transparent protective cover (452) is arranged to surround the outside of the display (410).

7. The chromatography column high-position storage tank liquid level prompting device according to claim 1, characterized in that: The second protection mechanism (450) is a transparent baffle (454) and is embedded on the outer wall of the explosion-proof housing (100), and the display assembly (400) at least further comprises: A projector (420) is arranged in the explosion-proof housing (100), and its projection lens (422) corresponds to the position of the transparent baffle (454).

8. The liquid level prompting device for a chromatography column high-position storage tank according to claim 1, characterized in that: The photosensitive element (130) is a photosensitive receiver.

9. The chromatography column high-position storage tank liquid level prompting device according to claim 1, characterized in that: A circulating fan (620) is also provided inside the explosion-proof housing (100), and a ventilation pipe (640) is provided on the explosion-proof housing (100) to connect to the outside of the factory building.

10. A column chromatography system, characterized in that: Include: Chromatographic column (700), with built-in filler; A high-level storage tank (800) is disposed above the chromatography column (700) and is provided with a raw material liquid inlet (810) and a liquid outlet (820) connected to the chromatography column (700); and The chromatography column high-level storage tank liquid level indication device according to any one of claims 1 to 9, wherein the connecting pipe (220) is connected to the bottom of the high-level storage tank (800).

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