A protein purification scaffold with good adaptability

Abstract

The utility model provides a protein purification bracket with good adaptability, which relates to the technical field of protein purification brackets and comprises a base, a fixing bracket is fixedly installed on the surface of the base, a side block is fixedly installed on the surface of the fixing bracket, a slide groove A is provided on the surface of the side block, a slider A is slidably connected inside the slide groove A, a long plate is fixedly installed on the surface of the slider A, a circular groove is provided on the surface of the long plate, a bracket A is fixedly installed on the surface of the fixing bracket, a limiting groove is provided on the surface of the fixing bracket, a paddle A is slidably connected inside the limiting groove, and in the utility model, the paddle A, a connecting rod, a bracket A, a bracket B, a cushion, a sliding rod and a spring are provided to clamp and fix protein purification columns of different diameters, thereby improving the adaptability of the protein purification bracket while avoiding the situation where the protein purification column is clamped and damaged, and the structure is simple and practical.

Description

Technical Field

[0001] The utility model relates to the technical field of protein purification brackets, in particular to a protein purification bracket with good adaptability. Background Art

[0002] The protein purification rack refers to a device used to support and fix the purification column during the protein purification process. It is one of the most important equipment in protein purification.

[0003] Publication No. CN212315987U discloses a purification column support suitable for manual protein purification, including a support, a liquid collection plate chute, an upper fixed circular hole, a waste liquid tank, and a base; the support is located on the base, and the support is door-shaped, including two side columns and an upper crossbeam; a row of upper fixed circular holes are evenly distributed on the upper crossbeam, and the upper fixed circular holes are through holes; a longitudinal liquid collection plate chute is provided in the middle of the two side columns, and a longitudinal slide is provided inside the longitudinal liquid collection plate chute; the middle flange of the liquid collection plate is located in the longitudinal slide; a waste liquid tank is provided inside the two side columns, and the waste liquid tank is in the shape of a rectangular disk. The utility model is suitable for a purification column support for manual protein purification, which is used to fix the purification column. After fixation, it is easy to collect liquid, which meets the needs of experiments. It is a purification column fixing frame suitable for different specifications. Although this device makes it easy to collect liquid, it lacks in the adaptability of the bracket. Since this fixing frame is only suitable for protein purification columns of the same model and the fixing device is not adjustable, when it is necessary to replace protein purification columns of different sizes according to experimental conditions, the purification bracket must be replaced together, which brings inconvenience to the protein purification work and reduces the adaptability of the protein purification bracket. Utility Model Content

[0004] The purpose of the utility model is to solve the technical problems raised in the above background technology.

[0005] The utility model adopts the following technical scheme: a protein purification bracket with good adaptability, comprising a base, a fixing frame is fixedly installed on the surface of the base, a side block is fixedly installed on the surface of the fixing frame, a slide groove A is provided on the surface of the side block, a slider A is slidably connected inside the slide groove A, a long plate is fixedly installed on the surface of the slider A, a circular groove is provided on the surface of the long plate, a bracket A is fixedly installed on the surface of the fixing frame, a limiting groove is provided on the surface of the fixing frame, a paddle A is slidably connected inside the limiting groove, a connecting rod is fixedly installed on the surface of the paddle A, a bracket B is fixedly installed on the surface of the connecting rod, a soft pad is fixedly installed on the surface of the bracket B, a sliding rod is fixedly installed on the surface of the connecting rod, a spring is sleeved on the surface of the sliding rod, and a waste liquid tank is provided on the surface of the base.

[0006] Preferably, the inner surface of the waste liquid tank is provided with a liquid discharge port, the inner surface of the waste liquid tank is provided with a slide groove B, the interior of the slide groove B is slidably connected with a slider B, a long rod is fixedly installed on the surface of the slider B, a paddle B is fixedly installed on the surface of the long rod, and a scraper is fixedly installed on the surface of the long rod. Here, the design of the liquid discharge port makes it easier for the experimenter to clean the waste liquid tank.

[0007] Preferably, one end of the spring is connected to the inner surface of the fixing frame, and the other end is connected to the surface of the connecting rod. Here, the design of the spring has the effect of moving the connecting rod and the bracket B toward the bracket A, thereby having the effect of clamping the protein purification column.

[0008] Preferably, a cushion is fixedly mounted on the surface of both the bracket A and the bracket B, and the cushion is made of natural rubber. Here, the design of the bracket A, the bracket B and the cushion increases the contact area between the bracket A and the bracket B and the protein purification column, thereby preventing the protein purification column from being pinched, and the natural rubber material design of the cushion protects the protein purification column.

[0009] Preferably, the connecting rod is slidably connected to the fixed frame, and the sliding rod is slidably connected to the fixed frame. Here, the sliding design of the connecting rod and the fixed frame facilitates the experimenter to control and adjust the spacing between the bracket A and the bracket B through the paddle A, thereby improving the adaptability of the protein purification bracket.

[0010] Preferably, the scraper is slidably connected to the waste liquid tank. Here, the sliding design of the scraper and the waste liquid tank facilitates the cleaning of the waste liquid tank, thereby avoiding the situation where impurities remaining in the waste liquid tank cause the solution to corrode and emit odor.

[0011] Preferably, the scraper is made of natural rubber. Here, the natural rubber material of the scraper prevents the scraper and the waste liquid tank from being scratched when the waste liquid tank is cleaned.

[0012] Compared with the prior art, the advantages and positive effects of the utility model are:

[0013] 1. In the utility model, by arranging the paddle A, the connecting rod, the bracket A, the bracket B, the cushion, the sliding rod and the spring, the protein purification columns with different diameters can be clamped and fixed, thereby improving the adaptability of the protein purification bracket and avoiding the protein purification column from being clamped and damaged. The utility model has a simple structure and strong practicality.

[0014] 2. In the utility model, the drain port, the slide chute B, the slider B, the long rod, the paddle B and the scraper are provided to facilitate the experimenter to scrape off the chemical solids remaining at the bottom of the waste liquid tank when cleaning the waste liquid tank, thereby avoiding the corrosion and odor caused by the residual chemical solids. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 A three-dimensional structural schematic diagram of a protein purification scaffold with good adaptability is proposed for the utility model;

[0016] Figure 2 The utility model proposes a schematic diagram of the exploded structure of a long plate, a spring, a sliding rod and a connecting rod in a protein purification bracket with good adaptability;

[0017] Figure 3 The utility model proposes a protein purification scaffold with good adaptability Figure 2 Enlarged view of point A in the middle;

[0018] Figure 4 The utility model provides a schematic diagram of the explosion structure of a long rod, a paddle B and a scraper in a protein purification bracket with good adaptability.

[0019] Legend:

[0020] 1. Base; 2. Fixed frame; 3. Side block; 4. Slide groove A; 5. Slider A; 6. Long board; 7. Round groove; 8. Bracket A; 9. Limiting groove; 10. Pick A; 11. Connecting rod; 12. Bracket B; 13. Cushion; 14. Slider; 15. Spring; 16. Waste liquid tank; 17. Drain port; 18. Slide groove B; 19. Slider B; 20. Long rod; 21. Pick B; 22. Scraper. DETAILED DESCRIPTION

[0021] In order to more clearly understand the above-mentioned purpose, features and advantages of the utility model, the utility model is further described below in conjunction with the accompanying drawings and embodiments. It should be noted that the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

[0022] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments of the following disclosure.

[0023] Embodiment 1

[0024] See also Figure 1-4The utility model provides a technical solution: a protein purification bracket with good adaptability, including a base 1, a fixing frame 2 is fixedly installed on the surface of the base 1, a side block 3 is fixedly installed on the surface of the fixing frame 2, a slide groove A4 is provided on the surface of the side block 3, a slider A5 is slidably connected inside the slide groove A4, a long plate 6 is fixedly installed on the surface of the slider A5, a circular groove 7 is provided on the surface of the long plate 6, a bracket A8 is fixedly installed on the surface of the fixing frame 2, a limiting groove 9 is provided on the surface of the fixing frame 2, a paddle A10 is slidably connected inside the limiting groove 9, a connecting rod 11 is fixedly installed on the surface of the paddle A10, the connecting rod 11 is slidably connected to the fixing frame 2, a bracket B12 is fixedly installed on the surface of the connecting rod 11, a cushion 13 is fixedly installed on the surface of the bracket A8 and the bracket B12, the cushion 13 is fixedly installed on the surface of the bracket A8 and the bracket B12, the material of the cushion 13 is natural rubber, and the design of the bracket A8, the bracket B12 and the cushion 13 increases the support of the bracket A8 and the bracket B12 and the contact area with the protein purification column, thereby preventing the protein purification column from being pinched and damaged, and the natural rubber material design of the soft pad 13 has the effect of protecting the protein purification column. A sliding rod 14 is fixedly installed on the surface of the connecting rod 11, and the sliding rod 14 is slidably connected to the fixing frame 2. The sliding design of the connecting rod 11 and the fixing frame 2 makes it easy for the experimenter to control and adjust the distance between the bracket A8 and the bracket B12 through the paddle A10, thereby improving the adaptability of the protein purification bracket. A spring 15 is sleeved on the surface of the sliding rod 14, one end of the spring 15 is connected to the inner surface of the fixing frame 2, and the other end is connected to the surface of the connecting rod 11. The design of the spring 15 has the effect of moving the connecting rod 11 and the bracket B12 toward the bracket A8, thereby clamping the protein purification column. A waste liquid tank 16 is provided on the surface of the base 1, and the design of the waste liquid tank 16 has the effect of collecting waste liquid during chemical experiments.

[0025] Embodiment 2

[0026] See also Figure 1-4 A drainage port 17 is provided on the inner surface of the waste liquid tank 16. The design of the drainage port 17 makes it easy for the experimenter to clean the waste liquid tank 16. A slide groove B18 is provided on the inner surface of the waste liquid tank 16. A slider B19 is slidably connected inside the slide groove B18. A long rod 20 is fixedly installed on the surface of the slider B19. A paddle B21 is fixedly installed on the surface of the long rod 20. A scraper 22 is fixedly installed on the surface of the long rod 20. The scraper 22 is slidably connected to the waste liquid tank 16. The sliding design of the scraper 22 and the waste liquid tank 16 makes it easy to clean the waste liquid tank 16, thereby avoiding the situation where residual impurities in the waste liquid tank 16 cause the solution to corrode and emit odor. The scraper 22 is made of natural rubber. The design of the natural rubber material of the scraper 22 prevents the scraper 22 and the waste liquid tank 16 from being scratched when the waste liquid tank 16 is cleaned.

[0027] Working principle: When using the protein purification bracket, you only need to turn the paddle A10, which will drive the connecting rod 11 to slide inside the fixed frame 2, and the connecting rod 11 will drive the bracket B12 and the soft pad 13 to slide. After the distance between the bracket A8 and the bracket B12 is increased, place the protein purification column on the top surface of the bracket A8 and the bracket B12, and then release the paddle A10. At this time, the connecting rod 11 and the sliding rod 14 will be acted upon by the elastic force of the spring 15 to push the bracket B12 and the soft pad 13 toward the protein purification column until the protein purification column is clamped between the bracket A8 and B. After the protein purification column is fixed, the protein purification experiment can be started. The adjustable design of the bracket A8 and the bracket B12 plays a role in adjusting the protein purification column to different The protein purification column of the tubular diameter can be clamped and fixed, thereby improving the adaptability of the protein purification bracket and avoiding the situation that the protein purification column is clamped and damaged. When the chemical solids in the waste liquid tank 16 need to be cleaned, it is only necessary to move the long rod 20 and the scraper 22 through the paddle B21, and the long rod 20 will drive the slider B19 to slide in the slide groove B18, and the scraper 22 will also slide on the surface of the waste liquid tank 16 until the chemical solids in the waste liquid tank 16 are scraped out of the waste liquid tank 16 through the drain port 17. The scraper 22 makes it easy for the experimenter to scrape off the chemical solids remaining at the bottom of the waste liquid tank 16 when cleaning the waste liquid tank 16, thereby avoiding the situation that corrosion and odor are caused by the residual chemical solids.

[0028] The above description is only a preferred embodiment of the present invention and does not limit the present invention in other forms. Any technician familiar with the profession may use the technical content disclosed above to change or modify it into an equivalent embodiment with equivalent changes and apply it to other fields. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A protein purification scaffold with good adaptability, comprising a base (1), characterized in that: A fixing frame (2) is fixedly mounted on the surface of the base (1), a side block (3) is fixedly mounted on the surface of the fixing frame (2), a sliding groove A (4) is provided on the surface of the side block (3), a sliding block A (5) is slidably connected inside the sliding groove A (4), a long board (6) is fixedly mounted on the surface of the sliding block A (5), a circular groove (7) is provided on the surface of the long board (6), a bracket A (8) is fixedly mounted on the surface of the fixing frame (2), and a limiting groove is provided on the surface of the fixing frame (2). (9), a paddle A (10) is slidably connected inside the limiting groove (9), a connecting rod (11) is fixedly installed on the surface of the paddle A (10), a bracket B (12) is fixedly installed on the surface of the connecting rod (11), a soft pad (13) is fixedly installed on the surface of the bracket B (12), a sliding rod (14) is fixedly installed on the surface of the connecting rod (11), a spring (15) is sleeved on the surface of the sliding rod (14), and a waste liquid tank (16) is opened on the surface of the base (1).

2. The protein purification scaffold with good adaptability according to claim 1, characterized in that: The inner surface of the waste liquid tank (16) is provided with a liquid discharge port (17), the inner surface of the waste liquid tank (16) is provided with a slide groove B (18), the interior of the slide groove B (18) is slidably connected with a slider B (19), the surface of the slider B (19) is fixedly mounted with a long rod (20), the surface of the long rod (20) is fixedly mounted with a paddle B (21), and the surface of the long rod (20) is fixedly mounted with a scraper (22).

3. The protein purification scaffold with good adaptability according to claim 1, characterized in that: One end of the spring (15) is connected to the inner surface of the fixing frame (2), and the other end is connected to the surface of the connecting rod (11).

4. The protein purification scaffold with good adaptability according to claim 1, characterized in that: A soft pad (13) is fixedly mounted on the surface of the bracket A (8) and the bracket B (12), and the material of the soft pad (13) is natural rubber.

5. The protein purification scaffold with good adaptability according to claim 1, characterized in that: The connecting rod (11) is slidably connected to the fixing frame (2), and the sliding rod (14) is slidably connected to the fixing frame (2).

6. The protein purification scaffold with good adaptability according to claim 2, characterized in that: The scraper (22) is slidably connected to the waste liquid tank (16).

7. The protein purification scaffold with good adaptability according to claim 2, characterized in that: The scraper (22) is made of natural rubber.

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