Capture and collection device
By designing a capture and collection device that cooperates with the accommodating cavity wall, the problem of low capture efficiency in the prior art is solved, and more efficient circulating tumor cell capture is achieved.
Patent Information
- Application Number
- CN202421239681.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-05-31
- Publication Date
- 2025-04-08
- Estimated Expiration
- 2034-05-31
AI Technical Summary
Existing capture devices have long trajectories in liquid samples, resulting in low capture efficiency, long time consuming and high possibility of missing.
A capture and collection device is designed, including a stage, a culture box and a capture assembly. The capture member in the capture assembly is movably disposed on the stage, and the peripheral surface cooperates with the cavity wall of the receiving cavity, so as to be able to rotate in the receiving cavity to capture the sample. The rotation of the capture member reduces linear movement, increases the contact area with the sample, and improves the capture efficiency.
The rotation of the capture member reduces the trajectory of the capture member moving in the receiving cavity, so that the capture member is in full contact with the sample, significantly improving the capture efficiency and reducing the possibility of missing.
Smart Images
Figure CN222729766U_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the field of cell detection, and in particular, to a capture and collection device. Background Art
[0002] The core of circulating tumor cell capture technology is to separate and identify trace amounts of circulating tumor cells from the blood. These cells may appear in the blood in the early stages of cancer, so their detection and analysis are extremely important for early diagnosis of cancer, disease monitoring, and formulation of treatment plans.
[0003] In the prior art, the probe of the capture device needs to move along a certain track (such as S-shaped, Z-shaped, etc.) in the well box of the culture plate to capture circulating tumor cells. The probe moves along a long track in the liquid sample, resulting in a long capture time, low efficiency, and a high possibility of omission. How to solve the above technical problems is what technicians in this field need to consider. Utility Model Content
[0004] The present application provides a capture and collection device to solve the problem of how to improve the capture efficiency.
[0005] The embodiment of the present application provides a capture collection device, including a carrier, a culture box and a capture assembly. The culture box is arranged on the carrier, and the culture box has a receiving cavity, and the receiving cavity is used to hold the sample. The capture assembly includes a capture member, and the capture member can be movably arranged on the carrier, and the peripheral surface of the capture member cooperates with the cavity wall of the receiving cavity, and the capture member can rotate in the receiving cavity to capture the sample.
[0006] Compared with the prior art, the capture and collection device in this embodiment cooperates with the cavity wall of the accommodating cavity through the circumferential surface of the capture piece to increase the contact area between the capture piece and the sample. The capture piece rotates in the accommodating cavity so that the circumferential surface of the capture piece passes through the entire accommodating cavity, thereby reducing the trajectory of the capture piece moving in the accommodating cavity and making the capture piece fully contact with the sample, so as to achieve the effect of improving the capture efficiency.
[0007] In a possible implementation manner, the cavity wall of the accommodating cavity is cylindrical, and the capturing member includes a curved surface, and the curved surface corresponds to the cavity wall of the accommodating cavity.
[0008] Furthermore, the arc surface is contoured with the cavity wall of the accommodating cavity so that the capturing member can rotate in the accommodating cavity. The capturing member reduces linear movement by rotating, thereby achieving the effect of improving the capturing efficiency.
[0009] In a possible implementation, the capture member has a strip-shaped cross section, and the capture member can be moved into the accommodating cavity and divide the accommodating cavity into two parts so that the sample is located on both sides of the capture member.
[0010] Furthermore, the capturing member extends into the accommodating cavity and divides the accommodating cavity into two parts, and the sample is located on both sides of the capturing member. When the capturing member rotates in the accommodating cavity, the capturing member fully stirs the sample so that the surface of the capturing member fully contacts the sample, thereby achieving the effect of improving the capturing efficiency.
[0011] In a possible implementation, the capture component further includes a moving member, the moving member is rotatably connected to the capture member, the moving member is movably disposed on the carrier, and the moving member is used to move the capture member.
[0012] In a possible implementation, the movable member includes a lifting frame and a horizontal displacement frame, the horizontal displacement frame is movably connected to the carrier along a first direction, the lifting frame is movably connected to the horizontal displacement frame along a vertical direction, and the capture member is rotatably connected to the lifting frame.
[0013] In a possible implementation manner, the moving member includes a mechanical arm, and the mechanical arm is rotatably connected to the capturing member.
[0014] In a possible embodiment, the capture and collection device also includes a washing box and a collecting box, wherein the collecting box is disposed on the carrier and spaced apart from the culture box, the collecting box is used to collect samples captured by the capture member, and the washing box is disposed between the collecting box and the culture box, and the washing box is used to clean the samples captured by the capture member.
[0015] In a possible implementation, the capture element includes a magnetic head having magnetism, and the target cells in the sample are combined with a medium so that the magnetic field of the magnetic head separates the target cells from the sample. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.
[0017] Figure 1 It is a three-dimensional schematic diagram of a capture and collection device according to an embodiment of the present application;
[0018] Figure 2 for Figure 1 A three-dimensional schematic diagram of a capture member of a capture collection device extending into a collection box;
[0019] Figure 3 for Figure 2The capture and collection device hides some parts from the top view;
[0020] Figure 4 for Figure 3 A cross-sectional view of the capture collection device along line II.
[0021] Description of main component symbols:
[0022] 1. Capture and collection device; 11. Carrier; 12. Culture box; 121. Accommodation chamber; 13. Capture assembly; 131. Capture member; 132. Arc surface; 133. Magnetic head; 134. Moving member; 135. Lifting frame; 136. Horizontal displacement frame; 137. Servo motor; 138. Electric motor; 139. Transmission belt; 14. First direction; 15. Collection box; 16. Washing box; 17. Carrying plate. DETAILED DESCRIPTION
[0023] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all of the embodiments.
[0024] Some embodiments of the present application are described in detail. In the absence of conflict, the following embodiments and features of the embodiments can be combined with each other.
[0025] Example
[0026] See also Figures 1 to 4 The present embodiment provides a capture and collection device 1, comprising a carrier 11, a culture box 12 and a capture assembly 13. The culture box 12 is disposed on the carrier 11, and the culture box 12 has a receiving cavity 121, and the receiving cavity 121 is used to hold the sample. The capture assembly 13 comprises a capture member 131, which is movably disposed on the carrier 11, and the peripheral surface of the capture member 131 cooperates with the cavity wall of the receiving cavity 121, and the capture member 131 can rotate in the receiving cavity 121 to capture the sample.
[0027] The capture and collection device 1 in this embodiment cooperates the circumferential surface of the capture member 131 with the cavity wall of the accommodating cavity 121 to increase the contact area between the capture member 131 and the sample. The capture member 131 rotates in the accommodating cavity 121 so that the circumferential surface of the capture member 131 passes through the entire accommodating cavity 121, thereby reducing the moving trajectory of the capture member 131 in the accommodating cavity 121 and making the capture member 131 fully contact with the sample to improve the capture efficiency.
[0028] In this embodiment, the capture element 131 includes a magnetic head 133 . The magnetic head 133 is magnetic. The sample is combined with the target cells in the sample through a specific medium, and then the target cells are separated from the sample by the magnetic field of the magnetic head 133 .
[0029] In one embodiment, the cavity wall of the accommodating cavity 121 is cylindrical, and the capturing member 131 includes an arc surface 132 , and the arc surface 132 corresponds to the cavity wall of the accommodating cavity 121 .
[0030] In this embodiment, the arc surface 132 is provided at both ends of the capture member 131 along the length direction, and a gap of 2 mm to 3 mm is left between the arc surface 132 and the accommodating cavity 121. The arc surface 132 is contoured with the cavity wall of the accommodating cavity 121, so that the capture member 131 can rotate in the accommodating cavity 121. The capture member 131 reduces linear movement by rotating, thereby improving the capture efficiency.
[0031] In one embodiment, the capture member 131 has a strip-shaped cross section. The capture member 131 can be moved into the accommodating chamber 121 and divide the accommodating chamber 121 into two parts so that the sample is located on both sides of the capture member 131 .
[0032] In this embodiment, the capturing member 131 extends into the accommodating chamber 121 and divides the accommodating chamber 121 into two parts. The sample is located on both sides of the capturing member 131. When the capturing member 131 rotates in the accommodating chamber 121, the capturing member 131 fully stirs the sample so that the surface of the capturing member 131 fully contacts the sample to improve the capturing efficiency.
[0033] In one embodiment, the capturing assembly 13 further includes a moving member 134 , which is rotatably connected to the capturing member 131 . The moving member 134 is movably disposed on the carrier 11 , and is used to move the capturing member 131 .
[0034] In this embodiment, the capture assembly 13 further includes an electric motor 138 and a transmission belt 139. The electric motor 138 is connected to the magnetic head 133 through the transmission belt 139 to drive the magnetic head 133 to rotate. The electric motor 138 and the transmission belt 139 are arranged on the moving member 134. The magnetic head 133 can also be rotated by other driving methods, and this embodiment is not limited thereto.
[0035] In one embodiment, the moving member 134 includes a lifting frame 135 and a horizontal displacement frame 136. The horizontal displacement frame 136 is movably connected to the carrier 11 along the first direction 14, the lifting frame 135 is movably connected to the horizontal displacement frame 136 along the vertical direction, and the capturing member 131 is rotatably connected to the lifting frame 135.
[0036] In this embodiment, the moving member 134 further includes a servo motor 137, which is used to provide driving force for the lifting frame 135 and the horizontal displacement frame 136. The lifting frame 135 is connected to a servo motor 137 through a belt to move the capture member 131 up and down; the horizontal displacement frame 136 is connected to another servo motor through a belt to move the capture member 131 along the first direction 14 to the position corresponding to the culture box 12.
[0037] In this embodiment, the electric motor 138 and the transmission belt 139 are arranged on the lifting frame 135, and such an arrangement can save the arrangement space of the driving structure.
[0038] In one embodiment, the moving member 134 includes a mechanical arm, which is rotatably connected to the capturing member 131 , and is used to move the capturing member 131 .
[0039] In this embodiment, the robotic arm may be a six-axis robotic arm or an industrial robot robotic arm, but this embodiment is not limited thereto.
[0040] In one embodiment, the capture and collection device 1 further includes a collection box 15 , which is disposed on the carrier 11 and spaced apart from the culture box 12 . The collection box 15 is used to collect the sample captured by the capture element 131 .
[0041] In one embodiment, the capture and collection device 1 further includes a washing box 16 , which is disposed between the collection box 15 and the culture box 12 . The washing box 16 is used to wash the sample captured by the capture element 131 .
[0042] In this embodiment, the capture and collection device 1 further includes a carrier plate 17, the culture box 12, the washing box 16 and the collection box 15 are sequentially arranged along the first direction 14 and fixed to the carrier plate 17, and the capture member 131 sequentially moves and operates along the first direction 14. The carrier plate 17 is positioned and placed on the carrier 11 so that the culture box 12, the washing box 16 and the collection box 15 respectively maintain appropriate relative positions with the capture member 131.
[0043] The capture and collection device 1 comprises the following steps when in use:
[0044] Step 1, placing the carrier plate 17 on the carrier 11;
[0045] Step 2, moving the capturing member 131 and lowering it into the containing chamber 121 of the culture box 12;
[0046] Step 3, capture, start the switch, and the capture member 131 rotates to start the capture operation;
[0047] Step 4, washing, moving the capture member 131 and lowering it to the washing box 16, starting the switch, and the capture member 131 rotates to start the washing operation;
[0048] Step 5, release, move the capture member 131 and lower it to the collection box 15 to complete the release operation.
[0049] Through the above steps, a series of operations are completed, and finally the circulating tumor cells are collected. The capture and collection device 1 of this embodiment can realize the function of the circulating tumor system, and the device has a light appearance, a simple structure, and is convenient and practical.
[0050] The above implementation modes are only used to illustrate the technical solutions of the present application and are not intended to limit the present application. Although the present application has been described in detail with reference to the above preferred implementation modes, a person skilled in the art should understand that the technical solutions of the present application may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present application.
Claims
1. A capture and collection device, characterized in that: include: Carrier; A culture box, arranged on the carrier, the culture box having a containing cavity, the containing cavity being used to hold the sample; The capture component includes a capture member, which is movably arranged on the carrier, and the peripheral surface of the capture member cooperates with the cavity wall of the accommodating cavity. The capture member can rotate in the accommodating cavity to capture the sample.
2. The capture and collection device according to claim 1, characterized in that: The cavity wall of the accommodating cavity is cylindrical, and the capturing member comprises an arc surface, and the arc surface corresponds to the cavity wall of the accommodating cavity.
3. The capture and collection device according to claim 1 or 2, characterized in that: The cross section of the capture member is in the shape of an elongated strip. The capture member can be moved into the containing cavity and divide the containing cavity into two parts so that the sample is located on both sides of the capture member.
4. The capture and collection device according to claim 1, characterized in that: The capture component further comprises a moving member, the moving member is rotatably connected to the capture member, the moving member is movably disposed on the carrier, and the moving member is used to move the capture member.
5. The capture and collection device according to claim 4, characterized in that: The movable member comprises a lifting frame and a horizontal displacement frame, the horizontal displacement frame is movably connected to the carrier along a first direction, the lifting frame is movably connected to the horizontal displacement frame along a vertical direction, and the capture member is rotatably connected to the lifting frame.
6. The capture and collection device according to claim 4, characterized in that: The moving member includes a mechanical arm, and the mechanical arm is rotatably connected to the capturing member.
7. The capture and collection device according to claim 1, characterized in that: The capture and collection device also includes a washing box and a collecting box. The collecting box is disposed on the carrier and spaced apart from the culture box. The collecting box is used to collect samples captured by the capture member. The washing box is disposed between the collecting box and the culture box. The washing box is used to clean the samples captured by the capture member.
8. The capture and collection device according to claim 1, characterized in that: The capture element comprises a magnetic head having magnetism, and the target cells in the sample are combined with a medium so that the magnetic field of the magnetic head separates the target cells from the sample.