A milk fat globule-like liposome extrusion device
By designing a milk-like fat globules liposome extrusion device, using continuous replenishment and intermittent expansion and contraction technology, efficient one-time extrusion molding of large-particle milk-like fat globules liposomes is achieved, and the problem of inefficient preparation in the prior art is solved.
Patent Information
- Application Number
- CN202421533282.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-01
- Publication Date
- 2025-04-11
- Estimated Expiration
- 2034-07-01
AI Technical Summary
In the prior art, when preparing large-particle milk fat globules, the step-by-step preparation process is cumbersome and takes a long time, and the extrusion device does not work, resulting in low preparation efficiency.
A milk-like fat-spheric liposome extrusion device is designed. Through continuous supply of the oil phase and the aqueous phase and intermittent expansion and contraction of the airbag, the intermittent passage of the extrusion rod is realized, and the primary extrusion molding of the large-particle size milk-spheric liposomes is realized.
The continuous preparation process of large-particle milk fat globules is realized, which improves the preparation efficiency and avoids the cumbersome and time-consuming step-by-step preparation.
Smart Images
Figure CN222737223U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of milk fat globule-like liposome preparation, in particular to a milk fat globule-like liposome extrusion device. Background Art
[0002] Milk fat is one of the main components of milk. It is dispersed in the milk plasma in the form of small globules or droplets, with an average particle size of 3μm-4μm and a maximum of 20μm. In addition to containing essential fatty acids and phospholipids for humans, milk fat globules are also an important source of fat-soluble vitamins such as vitamin A and vitamin D. Therefore, milk fat is a fat with high nutritional value. In the process of milk fat globules being released from mammary cells into breast milk, they are wrapped by the phospholipid layer (composed of phospholipids, sphingolipids, cholesterol and proteins) when passing through the cell membrane, so that the fat is evenly distributed in the water. Liposomes are artificially prepared carriers of active substances coated with a phospholipid bilayer membrane. Liposomes have a structure similar to that of cell membranes, so they are highly biocompatible, and their particle size is generally 0.1μm-1μm. The core of the liposome is an aqueous phase, and the fat-soluble components are distributed between the phospholipid bilayers. Although the liposomes are prepared to the size of milk fat globules, the osmotic effect brought by their small particle size is lost, but the load capacity increases after the particle size becomes larger, and the pressure required for preparation is reduced, which is easier to achieve.
[0003] At present, when preparing large-particle milk fat globule-like liposomes, thin film dispersion method, solvent injection method, reverse evaporation method and microfluidics technology are first used to prepare coarse milk fat globule-like liposomes, and then large-particle milk fat globule-like liposomes with uniform particle size can be obtained through extrusion process. Although the preparation of large-particle milk fat globule-like liposomes can be achieved under the above preparation method, on the one hand, the step-by-step preparation process is relatively cumbersome and time-consuming, and the extrusion device is not working when the milk fat globule-like liposomes are loaded during the extrusion process, resulting in the entire extrusion process of the milk fat globule-like liposomes being not continuous enough, thereby making the preparation efficiency of large-particle milk fat globule-like liposomes relatively low. Utility Model Content
[0004] 1. Technical issues to be resolved
[0005] The technical problem to be solved by the utility model is to provide a milk fat globule-like liposome extrusion device capable of realizing efficient preparation of large-size milk fat globule-like liposomes by continuous extrusion molding in view of the current status of the prior art.
[0006] (II) Technical solution
[0007] The utility model is implemented through the following technical scheme: the utility model proposes a milk fat globule-like liposome extrusion device, comprising an outer shell, an intermediate shell is arranged inside the outer shell, an inner shell is arranged inside the intermediate shell, an oil phase storage cavity is formed between the outer shell and the intermediate shell, a water phase storage cavity is formed between the intermediate shell and the inner shell, an air bag is installed on the inner side of the inner shell, support gaskets are evenly arranged on the lower part of the outer side wall of the air bag, an extrusion rod is installed on the side of the support gasket facing away from the air bag, a spring is installed between the outside of the extrusion rod and the inner shell, a microporous extrusion port is opened on the outer shell facing the extrusion rod, an oil phase inlet and an oil phase outlet of the oil phase storage cavity both extend out of the outer shell, and a water phase inlet and a water phase outlet of the water phase storage cavity both penetrate the outer shell.
[0008] Furthermore, the water phase inlet and the water phase outlet also sequentially penetrate the intermediate shell and the oil phase storage chamber.
[0009] By adopting the above technical solution, the water phase inlet and the water phase outlet are respectively connected to the external oil phase material supply pipeline, so that the continuous supply of the oil phase material can be ensured.
[0010] Furthermore, a sealing gasket is installed at the portion where the inner wall of the inner shell body is connected to the extrusion rod, and the sealing gasket is an annular structure.
[0011] By adopting the above technical solution, the sealing gasket can prevent the leakage of the water phase material in the water phase storage cavity.
[0012] Furthermore, the air inlet of the airbag is also connected to an air interface for controlling the air inlet and outlet of the airbag.
[0013] By adopting the above technical solution and connecting the air interface to an external air supply pipeline, intermittent expansion and contraction of the airbag can be achieved.
[0014] Furthermore, the air interface sequentially passes through the inner shell, the water phase storage chamber, the intermediate shell, the oil phase storage chamber and the outer shell.
[0015] By adopting the above technical solution, convenient supply of external air into the airbag can be ensured.
[0016] Furthermore, the extrusion rod passes through the spring, and the spring is hooked and connected to the outer wall of the extrusion rod and the inner wall of the inner shell.
[0017] By adopting the above technical solution, the spring is mainly used to realize the automatic reset of the squeezing rod when the airbag is contracted, so as to facilitate the squeezing operation again.
[0018] Furthermore, the outer shell, the intermediate shell and the inner shell are all made of stainless steel, and the intermediate shell and the inner shell are both open structures facing the extrusion rod.
[0019] By adopting the above technical solution, it can be ensured that the extrusion rod passes through the outer shell, the intermediate shell and the inner shell conveniently, so as to realize the convenient preparation of large-size milk fat globule-like liposomes.
[0020] (III) Beneficial effects
[0021] Compared with the prior art, the utility model has the following beneficial effects:
[0022] In order to solve the problem that, in the current preparation of large-particle-size milk fat globule-like liposomes, thin film dispersion method, solvent injection method, reverse evaporation method and microfluidics technology are first used to prepare coarse milk fat globule-like liposomes, and then large-particle-size milk fat globule-like liposomes with uniform particle size are obtained through extrusion process, although the preparation of large-particle-size milk fat globule-like liposomes can be achieved under the above preparation method, on the one hand, the step-by-step preparation process is relatively cumbersome and time-consuming, and on the other hand, the extrusion device is not working when the milk fat globule-like liposomes are loaded during the extrusion process, resulting in the entire extrusion process of the milk fat globule-like liposomes being not continuous enough, thereby making the preparation efficiency of the large-particle-size milk fat globule-like liposomes relatively low. The utility model is used with the help of oil phase The inlet and the oil phase outlet can ensure the continuous replenishment of the oil phase material in the oil phase storage chamber. The water phase inlet and the water phase outlet can ensure the continuous replenishment of the water phase material in the water phase storage chamber. At the same time, with the intermittent expansion and contraction of the air bag, the extrusion rod can intermittently pass through the water phase storage chamber and the oil phase storage chamber, so that the water phase material and the oil phase material can be extruded through the extrusion port under the action of the extrusion rod to achieve the preparation of large-particle milk fat globule liposomes. Under this preparation method, the preparation of large-particle milk fat globule liposomes is through one-time extrusion molding, and the replenishment of oil phase material and water phase material is continuous, which makes the entire preparation process of large-particle milk fat globule liposomes more continuous and the preparation efficiency is higher. BRIEF DESCRIPTION OF THE DRAWINGS
[0023] Figure 1 This is a schematic structural diagram of a milk fat globule-like liposome extrusion device according to the utility model;
[0024] Figure 2 The utility model is a kind of milk fat globule liposome extrusion device Figure 1 Enlarged view of point A in the middle.
[0025] The following are the descriptions of the reference numerals:
[0026] 1. Outer shell; 2. Intermediate shell; 3. Inner shell; 4. Sealing gasket; 5. Spring; 6. Support gasket; 7. Airbag; 8. Water phase inlet; 9. Oil phase inlet; 10. Air interface; 11. Oil phase outlet; 12. Water phase outlet; 13. Extrusion port; 14. Oil phase storage chamber; 15. Water phase storage chamber; 16. Extrusion rod. DETAILED DESCRIPTION
[0027] In order to make the purpose, technical solution and advantages of the utility model more clear, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the utility model and are not used to limit the utility model.
[0028] like Figure 1-Figure 2 As shown, a milk fat globule-like liposome extrusion device in this embodiment includes an outer shell 1, an intermediate shell 2 is arranged inside the outer shell 1, an inner shell 3 is arranged inside the intermediate shell 2, an oil phase storage chamber 14 is formed between the outer shell 1 and the intermediate shell 2, a water phase storage chamber 15 is formed between the intermediate shell 2 and the inner shell 3, an air bag 7 is installed inside the inner shell 3, support pads 6 are evenly distributed on the lower part of the outer wall of the air bag 7, an extrusion rod 16 is installed on the side of the support pad 6 facing away from the air bag 7, and a spring 5 is installed between the outside of the extrusion rod 16 and the inner shell 3, and the spring 5 is mainly used to realize the extrusion rod 16 in the air bag 7 Automatic reset during contraction to facilitate the next extrusion operation. A microporous extrusion port 13 is provided on the outer shell 1 opposite to the extrusion rod 16. The oil phase inlet 9 and the oil phase outlet 11 of the oil phase storage chamber 14 extend out of the outer shell 1. The water phase inlet 8 and the water phase outlet 12 of the water phase storage chamber 15 penetrate the outer shell 1. After the extrusion rod 16 passes through the outer shell 1, the intermediate shell 2 and the inner shell 3 conveniently, the molding and preparation of large-size milk fat globule-like liposomes can be realized. The water phase inlet 8 and the water phase outlet 12 are respectively connected to the external oil phase material supply pipeline to ensure the continuous supply of the oil phase material.
[0029] like Figure 1-Figure 2 As shown, in this embodiment, the water phase inlet 8 and the water phase outlet 12 also pass through the intermediate shell 2 and the oil phase storage chamber 14 in sequence, and a sealing gasket 4 is also installed at the position where the inner wall of the inner shell 3 is connected to the extrusion rod 16. The sealing gasket 4 is an annular structure. The sealing gasket 4 can prevent the leakage of the water phase material in the water phase storage chamber 15. The air inlet of the airbag 7 is also connected to an air interface 10 for controlling the air intake and outlet of the airbag 7. The air interface 10 is connected to the external air supply pipeline to realize intermittent expansion and contraction of the airbag 7. The air interface 10 passes through the inner shell 3, the water phase storage chamber 15, the intermediate shell 2, the oil phase storage chamber 14 and the outer shell 1 in sequence, which can ensure the convenient supply of external air to the airbag 7.
[0030] like Figure 1-Figure 2As shown, in this embodiment, the extrusion rod 16 passes through the spring 5, and the spring 5 is hooked and connected to the outer wall of the extrusion rod 16 and the inner wall of the inner shell 3. The outer shell 1, the intermediate shell 2 and the inner shell 3 are all made of stainless steel, and the intermediate shell 2 and the inner shell 3 are both open structures facing the extrusion rod 16.
[0031] The specific implementation process of this embodiment is as follows: when preparing large-particle-size milk fat globule-like liposomes, firstly, the oil phase material is continuously supplied to the oil phase storage chamber 14 by means of the oil phase inlet 9 and the oil phase outlet 11, and the water phase material is continuously supplied to the water phase storage chamber 15 by means of the water phase inlet 8 and the water phase outlet 12, and then the intermittent expansion and contraction of the airbag 7 is coordinated to make the extrusion rod 16 intermittently pass through the water phase storage chamber 15 and the oil phase storage chamber 14, so that the water phase material and the oil phase material are extruded through the extrusion port 13 under the action of the extrusion rod 16 to achieve the preparation of large-particle-size milk fat globule liposomes. Because in this preparation method, the preparation of large-particle-size milk fat globule liposomes is through one-time extrusion molding, and the supply of oil phase material and water phase material is continuous, so that the entire preparation process of large-particle-size milk fat globule liposomes is more continuous and the preparation efficiency is higher.
[0032] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.
Claims
1. A milk fat globule-like liposome extrusion device, characterized in that: The invention comprises an outer shell (1), an intermediate shell (2) is arranged on the inner side of the outer shell (1), an inner shell (3) is arranged on the inner side of the intermediate shell (2), an oil phase storage chamber (14) is formed between the outer shell (1) and the intermediate shell (2), a water phase storage chamber (15) is formed between the intermediate shell (2) and the inner shell (3), an air bag (7) is installed on the inner side of the inner shell (3), and support pads (6) are evenly arranged on the lower part of the outer side wall of the air bag (7), and the back of the support pads (6) are An extrusion rod (16) is installed on one side of the airbag (7), a spring (5) is installed between the outside of the extrusion rod (16) and the inner shell (3), a microporous extrusion port (13) is provided on the outer shell (1) opposite to the extrusion rod (16), an oil phase inlet (9) and an oil phase outlet (11) of the oil phase storage chamber (14) both extend out of the outer shell (1), and a water phase inlet (8) and a water phase outlet (12) of the water phase storage chamber (15) both penetrate the outer shell (1).
2. A milk fat globule-like liposome extrusion device according to claim 1, characterized in that: The water phase inlet (8) and the water phase outlet (12) also sequentially penetrate the intermediate shell (2) and the oil phase storage chamber (14).
3. The milk fat globule-like liposome extrusion device according to claim 1, characterized in that: A sealing gasket (4) is also installed at the portion where the inner wall of the inner shell (3) is connected to the extrusion rod (16), and the sealing gasket (4) is an annular structure.
4. The milk fat globule-like liposome extrusion device according to claim 1, characterized in that: The air inlet of the airbag (7) is also connected to an air interface (10) for controlling the air inlet and outlet of the airbag (7).
5. The milk fat globule-like liposome extrusion device according to claim 4, characterized in that: The air interface (10) sequentially passes through the inner shell (3), the water phase storage chamber (15), the intermediate shell (2), the oil phase storage chamber (14), and the outer shell (1).
6. The milk fat globule-like liposome extrusion device according to claim 1, characterized in that: The extrusion rod (16) passes through the spring (5), and the spring (5) is hooked and connected to the outer wall of the extrusion rod (16) and the inner wall of the inner shell (3).
7. The milk fat globule-like liposome extrusion device according to claim 1, characterized in that: The outer shell (1), the intermediate shell (2) and the inner shell (3) are all made of stainless steel, and the intermediate shell (2) and the inner shell (3) are both open structures at locations facing the extrusion rod (16).