Antibody elution device

Abstract

The utility model provides an antibody elution device, relates to antibody elution field, include: elution machine, seal cover and antibody test tube, the upper surface of elution machine is buckled with the seal cover, the middle part of seal cover is inserted with antibody test tube, the lower end face of seal cover is embedded and connected with temperature regulation disc, the outer side face of temperature regulation disc is equipped with big gear wheel, the big gear wheel is equipped with big gear wheel, the big gear wheel is equipped with big gear wheel. The left side of the large gear is connected with a motor through a small gear, cooling pipes are embedded into the lower end face of the temperature adjusting disc in a bilateral symmetry mode, cooling cavities are formed in the inner sides of the cooling pipes, pipe opening plugs are plugged at branch cavity openings in the lower ends of the cooling pipes, and heating rods are symmetrically installed on the front side and the rear side of the lower end face of the temperature adjusting disc. The utility model solves the problem that the temperature change speed of a water body injected by a water injection structure in the prior art affects the elution effect of antibodies in the immune tube.

Description

Technical Field

[0001] The utility model relates to the technical field of antibody elution, in particular to an antibody elution device. Background Art

[0002] The principle of antibody elution is mainly to affect the binding force between the antibody and the target molecule by changing the ion concentration, pH value, temperature of the solution or adding specific chelating agents. After searching, the prior art (Announcement No.: CN202223445504.3) is a phage antibody elution device. The text records that "by providing a water injection structure, when it is necessary to inject cold water into the beaker, the auxiliary sheet is taken and pulled upward, and the auxiliary sheet will drive the connecting sheet to pull the sealing plug out from the hole body, so that the hole body can be opened, and cold water can be injected into the beaker through the hole body. By inserting the sealing plug into the hole body, the hole body can be sealed conveniently." However, the temperature change rate of the water injected by the water injection structure in the prior art affects the antibody elution effect in the immune tube. Utility Model Content

[0003] In order to overcome the defects of the prior art, an antibody elution device is now provided to solve the problem that the temperature change rate of the water injected by the water injection structure in the prior art affects the antibody elution effect in the immune tube.

[0004] To achieve the above object, an antibody elution device is provided, comprising: an elution machine, a sealing cover and an antibody test tube, wherein the sealing cover is buckled on the upper surface of the elution machine, and the antibody test tube is plugged into the middle of the sealing cover.

[0005] The lower end surface of the sealing cover is embedded with a temperature regulating disk, a large gear is installed on the outer side of the temperature regulating disk, and a motor is connected to the left side of the large gear through a small gear. A cooling pipe is symmetrically embedded in the lower end surface of the temperature regulating disk, a cooling cavity is opened inside the cooling pipe, and a pipe plug is sealed at the branch cavity opening at the lower end of the cooling pipe. Heating rods are symmetrically installed on the front and rear sides of the lower end surface of the temperature regulating disk.

[0006] Furthermore, a shock absorbing base is sleeved on the outer side of the lower end surface of the washing and drying machine, a shock absorber is embedded and fixed on the upper surface of the shock absorbing base, and the upper end of the shock absorber supports the washing and drying machine.

[0007] Furthermore, an ultrasonic mechanism is installed inside the washing and extracting machine, a sponge pad is bonded to the bottom surface of the inner cavity of the washing and extracting machine, and an antibody test tube is attached to the upper end of the sponge pad.

[0008] Furthermore, a motor is fixed on the upper surface of the sealing cover, a liquid injection port is opened at the right end of the motor, and a test tube plug is connected to the tube port plug at the upper end of the antibody test tube.

[0009] Furthermore, two groups of liquid guiding grooves are symmetrically provided on the inner side of the temperature regulating disk; and the liquid guiding grooves are located below the liquid injection port, and the lower ends of the liquid guiding grooves are communicated with the cooling cavity inside the cooling tube.

[0010] Furthermore, a small gear is connected to the lower shaft of the motor, a large gear is meshed and driven on the right side of the small gear, and the cooling tube and the heating rod are distributed in a ring shape on the outside of the antibody test tube.

[0011] Furthermore, the temperature regulating disk, the motor, the small gear, the large gear, the cooling chamber, the cooling tube and the heating rod constitute a temperature regulating structure of the washing and drying machine.

[0012] The beneficial effect of the utility model is that the antibody eluting device of the utility model utilizes the cooling tube and the heating rod symmetrically installed at the lower end of the temperature regulating disk, and cools or heats the water injected into the washing machine by the cooling medium added into the cooling tube or the heating rod being electrically heated, and at the same time, the temperature regulating disk drives the cooling tube and the heating rod to mix and stir with the water body, so that the water injection temperature in the washing machine is more uniform, and it is convenient to adjust the temperature change of the water body during antibody elution, effectively maintain the appropriate temperature required for antibody elution, and improve the elution effect of the antibody elution device. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a front view structural schematic diagram of the antibody elution device according to an embodiment of the utility model.

[0014] Figure 2 It is a schematic diagram of the front cross-sectional structure of the antibody eluting device according to an embodiment of the utility model.

[0015] Figure 3 It is a front view cross-sectional structural schematic diagram of the temperature regulating disk and the cooling tube according to an embodiment of the utility model.

[0016] Figure 4 The figure is a schematic top view of the temperature regulating disk and the cooling tube according to an embodiment of the utility model.

[0017] In the figure: 1. washing and drying machine; 11. shock-absorbing base; 12. ultrasonic mechanism; 13. sponge pad; 14. shock absorber; 2. sealing cover; 21. liquid filling port; 3. antibody test tube; 31. test tube plug; 4. temperature adjustment disk; 41. motor; 42. small gear; 43. large gear; 44. liquid guide groove; 5. cooling tube; 51. tube mouth plug; 52. cooling chamber; 6. heating rod. DETAILED DESCRIPTION

[0018] Reference Figures 1 to 4 As shown, the utility model provides an antibody eluting device, comprising: an eluting machine 1, a sealing cover 2 and an antibody test tube 3. The sealing cover 2 is buckled on the upper surface of the eluting machine 1, and the antibody test tube 3 is plugged into the middle of the sealing cover 2.

[0019] A temperature regulating disk 4 is embedded in the lower end surface of the sealing cover 2, a large gear 43 is installed on the outer side of the temperature regulating disk 4, a motor 41 is connected to the left side of the large gear 43 through a small gear 42, a cooling pipe 5 is symmetrically embedded in the lower end surface of the temperature regulating disk 4, a cooling cavity 52 is opened inside the cooling pipe 5, a pipe mouth plug 51 is sealed at the branch cavity mouth of the lower end of the cooling pipe 5, and a heating rod 6 is symmetrically installed on the front and rear sides of the lower end surface of the temperature regulating disk 4.

[0020] In use, the antibody test tube 3 containing the antibody is inserted into the water in the inner cavity of the washing machine 1, and ultrasonic elution is started. When the temperature sensor built into the washing machine 1 detects a large temperature change during elution, the water injected into the washing machine is cooled or heated by adding a cooling medium into the cooling tube 5 or the heating rod 6 is powered on to heat the water to maintain the appropriate temperature required for antibody elution. At the same time, the temperature regulating disk 4 drives the cooling tube 5 and the heating rod 6 to mix and stir with the water body, so that the temperature is quickly and evenly transferred.

[0021] In this embodiment, a shock absorbing base 11 is sleeved on the outer side of the lower end surface of the washing and extracting machine 1, and a shock absorber 14 is embedded and fixed on the upper surface of the shock absorbing base 11, and the upper end of the shock absorber 14 supports the washing and extracting machine 1. An ultrasonic mechanism 12 is installed inside the washing and extracting machine 1, and a sponge pad 13 is bonded to the bottom surface of the inner cavity of the washing and extracting machine 1; and an antibody test tube 3 is attached to the upper end of the sponge pad 13.

[0022] As a preferred embodiment, the shock absorbing base 11 and the shock absorber 14 are convenient for stably supporting the washing and extracting machine 1. The ultrasonic mechanism 12 is used to generate ultrasonic waves to elute the antibody solution in the antibody test tube 3.

[0023] In this embodiment, a motor 41 is fixed on the upper surface of the sealing cover 2 , a liquid injection port 21 is provided at the right end of the motor 41 , and a test tube plug 31 is connected to the tube port plug at the upper end of the antibody test tube 3 .

[0024] As a preferred embodiment, the test tube plug 31 blocks the tube mouth of the antibody test tube 3 to prevent dust and impurities from the external environment from falling into the antibody test tube 3, so that the antibody and solution in the antibody test tube 3 are eluted through the ultrasonic in and out of the washing machine 1.

[0025] In this embodiment, two groups of liquid guide grooves 44 are symmetrically provided inside the temperature regulating disk 4; and the liquid guide grooves 44 are located below the liquid injection port 21, and the lower ends of the liquid guide grooves 44 are connected to the cooling cavity 52 inside the cooling tube 5. A small gear 42 is connected to the lower end of the motor 41, and a large gear 43 is meshed and driven on the right side of the small gear 42. The cooling tube 5 and the heating rod 6 are distributed in a ring shape outside the antibody test tube 3.

[0026] As a preferred embodiment, the liquid guide groove 44 facilitates the cooling medium injected from the liquid injection port 21 to be introduced into the cooling cavity 52 of the cooling tube 5, so that the cooling tube 5 transfers the temperature of the cooling medium to the water injected into the washing and drying machine 1. The motor 41 drives the temperature adjustment disk 4 to rotate through the gear meshing rotation, so that the temperature of the cooling tube 5 and the heating rod 6 can be evenly transferred to the water in the washing and drying machine 1.

[0027] In this embodiment, the temperature regulating disk 4 , the motor 41 , the small gear 42 , the large gear 43 , the cooling chamber 52 , the cooling tube 5 and the heating rod 6 constitute the temperature regulating structure of the washing and drying machine 1 .

[0028] As a preferred embodiment, the temperature regulating structure of the washing and extracting machine 1 is convenient for regulating the temperature change of the water body during antibody elution, effectively maintaining the appropriate temperature required for antibody elution, and improving the elution effect of the antibody elution device.

[0029] The antibody elution device of the utility model can effectively solve the problem in the prior art that the temperature change rate of water injected by the water injection structure affects the antibody elution effect in the immune tube, facilitates the water injection temperature in the elution machine to be more uniform, facilitates the adjustment of water temperature changes during antibody elution, effectively maintains the appropriate temperature required for antibody elution, improves the elution effect of the antibody elution device, and is suitable for the antibody elution device.

Claims

1. An antibody elution device, comprising: A washing and dewatering machine (1), a sealing cover (2) and an antibody test tube (3), wherein the upper surface of the washing and dewatering machine (1) is buckled with the sealing cover (2), and the middle of the sealing cover (2) is plugged with the antibody test tube (3), characterized in that: The lower end surface of the sealing cover (2) is embedded with a temperature regulating disk (4), the outer side surface of the temperature regulating disk (4) is mounted with a large gear (43), the left side of the large gear (43) is connected to a motor (41) via a small gear (42), the lower end surface of the temperature regulating disk (4) is symmetrically embedded with a cooling tube (5), the inner side of the cooling tube (5) is provided with a cooling cavity (52), the lower end branch cavity of the cooling tube (5) is blocked with a tube plug (51), and the front and rear sides of the lower end surface of the temperature regulating disk (4) are symmetrically mounted with heating rods (6).

2. An antibody elution device according to claim 1, characterized in that: A shock absorbing base (11) is sleeved on the outer side of the lower end surface of the washing and drying machine (1), a shock absorber (14) is embedded and fixed on the upper surface of the shock absorbing base (11), and the upper end of the shock absorber (14) supports the washing and drying machine (1).

3. An antibody elution device according to claim 1, characterized in that: An ultrasonic mechanism (12) is installed inside the washing and dewatering machine (1), a sponge pad (13) is bonded to the bottom surface of the inner cavity of the washing and dewatering machine (1), and an antibody test tube (3) is attached to the upper end of the sponge pad (13).

4. An antibody elution device according to claim 1, characterized in that: A motor (41) is fixed on the upper surface of the sealing cover (2), a liquid injection port (21) is provided at the right end of the motor (41), and a test tube plug (31) is connected to the tube port plug at the upper end of the antibody test tube (3).

5. An antibody elution device according to claim 1, characterized in that: Two groups of liquid guide grooves (44) are symmetrically provided on the inner side of the temperature regulating disk (4); the liquid guide grooves (44) are located below the liquid injection port (21); and the lower ends of the liquid guide grooves (44) are connected to the cooling cavity (52) inside the cooling tube (5).

6. An antibody elution device according to claim 1, characterized in that: The lower end of the motor (41) is connected to a small gear (42), and the right side of the small gear (42) is meshed with a large gear (43). The cooling tube (5) and the heating rod (6) are distributed in a ring shape on the outside of the antibody test tube (3).

7. An antibody elution device according to claim 1, characterized in that: The temperature regulating disk (4), the motor (41), the small gear (42), the large gear (43), the cooling chamber (52), the cooling tube (5) and the heating rod (6) constitute the temperature regulating structure of the washing and drying machine (1).

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