Automatic kit loading device and chemiluminescence immunoassay analyzer

Abstract

The utility model relates to an automatic kit loading device which comprises a round reagent bin shell, a control assembly and a taking and placing assembly, a rotating disc is arranged in the reagent bin shell, a mounting base is fixedly connected to the reagent bin shell, a kit carrier is rotatably mounted on the mounting base, a plurality of first clamping grooves are formed in the rotating disc, a plurality of second clamping grooves are formed in the kit carrier, and the first clamping grooves are communicated with the second clamping grooves. The first clamping grooves and the second clamping grooves coincide in the vertical direction, at least one of the second clamping grooves is used for containing a first kit, at least one of the second clamping grooves is used for containing a second kit, the driving assembly on the mounting base drives the kit carrier to rotate, and the control assembly controls a gripper of the taking and placing assembly to vertically ascend and descend. When a first kit on the first clamping groove needs to be replaced, the gripper is controlled to grab out the first kit and place the first kit on the second clamping groove, and then a second kit used for replacement on the kit carrier is grabbed and placed on the first clamping groove. The automatic kit loading device provided by the utility model can realize non-stop replacement of the kit.

Description

Technical Field

[0001] The present application relates to the field of medical devices, and in particular to an automatic reagent kit loading device and a chemiluminescent immunoassay analyzer. Background Art

[0002] The chemiluminescent immunoassay analyzer is a tool that uses immunodiagnostic technology to diagnose some diseases. The automatic reagent kit loading device is a relatively important component of the chemiluminescent immunoassay analyzer, which is directly related to the effectiveness of the reagent use and the accuracy of the analysis and detection results. The existing automatic reagent kit loading device generally includes a reagent kit and a turntable. The turntable is provided with a slot for placing the reagent kit. The reagent kit on the turntable is a consumable. After the reagent inside is used up, it is necessary to stop the machine and manually take out the empty reagent kit and place a new reagent kit. This shutdown and replacement operation reduces the efficiency of reagent kit replacement. In addition, when the chemiluminescent immunoassay analyzer is working, the liquid addition needle draws the reagent from the reagent kit, and the shutdown replacement makes it impossible to carry out related diagnostic work, which in turn affects the overall working efficiency of the instrument.

[0003] Therefore, how to replace the reagent kit on the turntable without stopping the operation of the reagent kit automatic loading device is a problem that needs to be solved urgently. Utility Model Content

[0004] In view of the technical problems existing in the prior art, the present application proposes, on the one hand, an automatic loading device for a reagent kit, comprising a circular reagent compartment shell and a control component, wherein a turntable is arranged concentrically inside the reagent compartment shell, a pick-and-place component is arranged outside the reagent compartment shell, and a plurality of first card slots are arranged on the circumferential edge of the turntable; an elongated mounting seat is arranged above the reagent compartment shell on one side facing the pick-and-place component, and the two ends of the short sides of the mounting seat are respectively fixedly connected to the circumferential edge of the reagent compartment shell in any one diameter direction; a reagent kit carrier is rotatably mounted on the mounting seat, the reagent kit carrier is arranged concentrically with the turntable, and a plurality of second card slots are arranged on the reagent kit carrier, At least one of them is used to place the first reagent kit, and at least one is used to place the second reagent kit, the first card slot is located below the second card slot and the two can overlap with each other in the vertical direction; the mounting seat is also provided with a driving component for driving the reagent kit carrier to rotate relative to the center of the reagent compartment shell; the pick-and-place component includes a gripper located above the first card slot and the second card slot, and the control component controls the vertical lifting and lowering movement of the gripper; when there is a first reagent kit on the first card slot that needs to be replaced, the gripper is controlled to grab the first reagent kit and place it on the second card slot, and then grab the second reagent kit for replacement on the reagent kit carrier and place it on the first card slot.

[0005] Optionally, an identification component is provided on the circumferential edge of the reagent compartment shell, and the identification component includes a barcode scanner and a reflective optical coupler. The reagent kit is provided with a unique identity tag. When the reagent kit is placed on the second card slot, the barcode scanner reads the identity tag, and the reflective optical coupler confirms whether there is a reagent kit on the second card slot and sends a signal to the control component.

[0006] Optionally, a cover plate is provided on the reagent compartment housing, and the cover plate is located between the first card slot and the second card slot.

[0007] Optionally, a window is provided on the cover plate to facilitate replacement of the pick-and-place component, and the window is located below the pick-and-place component.

[0008] Optionally, the cover is also provided with a manual replacement window for manual replacement of the reagent kit.

[0009] Optionally, the cover plate is also provided with a reagent extraction port for the liquid adding needle to extract the reagent in the reagent kit.

[0010] Optionally, the number of the second card slots is 4, 1 of which is used to place the first reagent kit and 3 of which are used to place the second reagent kit.

[0011] Optionally, the driving assembly includes a driving motor; a cross-stick bearing is provided on the mounting seat, a pulley is concentrically provided on the rotatable portion thereof, and the reagent kit carrier is concentrically provided on the pulley; a belt is sleeved on the output end of the driving motor, and the other end of the belt is sleeved on the outer circumference of the pulley.

[0012] Optionally, the driving component includes a zero-position optical coupler, and a baffle is arranged under the reagent kit carrier, and the baffle rotates synchronously with the reagent kit carrier. When the baffle is located at the zero-position optical coupler position, it is determined that the reagent kit carrier is at the zero position at this time, and the control component sets the rotation angle of the reagent kit carrier according to the zero position.

[0013] On the other hand, the present application proposes a chemiluminescent immunoassay analyzer, including a liquid adding needle and a reagent mixing device, wherein the reagent mixing device includes an automatic reagent kit loading device as described in any of the above claims, and the reagent mixing device is used to mix the reagent in the reagent bottle so that the liquid adding needle absorbs the mixed reagent to a predetermined position.

[0014] According to the automatic loading device for the reagent kit provided in the embodiment of the present application, by setting the first card slot on the turntable and the second card slot on the reagent kit carrier, by controlling the rotation of the reagent kit carrier, the grabbing and placing of the reagent kit by the pick-and-place component, the reagent kit can be replaced without stopping the machine, thereby effectively improving the replacement efficiency of the reagent kit and ensuring the continuous operation of the chemiluminescence immunoassay analyzer. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Below, the preferred embodiments of the present application will be further described in detail with reference to the accompanying drawings, wherein:

[0016] Figure 1 is a three-dimensional diagram of a reagent kit automatic loading device according to an embodiment of the present application;

[0017] Figure 2 is a three-dimensional diagram of a reagent kit automatic loading device with an additional cover plate according to an embodiment of the present application;

[0018] Figure 3 is a schematic structural diagram of a cover plate according to an embodiment of the present application;

[0019] Figure 4 is a schematic structural diagram of a reagent kit carrier and a mounting base according to an embodiment of the present application;

[0020] Figure 5 is an assembly diagram of a drive assembly and a reagent kit carrier according to an embodiment of the present application;

[0021] Figure 6 is a schematic structural diagram of a zero-position optical coupler and a baffle according to an embodiment of the present application;

[0022] Figure 7 is a schematic diagram of the structure of a pick-and-place assembly according to an embodiment of the present application;

[0023] Figure 8 It is a schematic diagram of the structure of the identification component according to an embodiment of the present application. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0025] In the following detailed description, reference may be made to the various specification drawings that are part of the present application and are used to illustrate specific embodiments of the present application. In the accompanying drawings, similar reference numerals describe substantially similar components in different figures. The various specific embodiments of the present application are described below in sufficient detail so that a person of ordinary skill in the art with relevant knowledge and skills in the art can implement the technical solutions of the present application. It should be understood that other embodiments may also be used or structural, logical or electrical changes may be made to the embodiments of the present application.

[0026] Figure 1is a three-dimensional diagram of the automatic loading device for the reagent kit according to an embodiment of the present application. Figure 1 As shown, the present application provides an automatic loading device for a reagent kit, including a circular reagent compartment shell 10 and a control component (not shown in the figure), a turntable 20 is concentrically arranged inside the reagent compartment shell 10, and a pick-and-place component 30 is arranged outside the reagent compartment shell 10.

[0027] The diameter of the reagent compartment housing 10 is usually larger than the diameter of the turntable 20, and is disposed around the turntable 20. A plurality of first slots 21 are disposed along the circumference of the turntable 20 for placing reagent reagents.

[0028] An elongated mounting seat 40 is disposed above the reagent compartment housing 10 on one side facing the pick-and-place assembly 30, and the two ends of the short side of the mounting seat 40 are respectively fixedly connected to the circumferential edge of the reagent compartment housing 10 in any diameter direction. One or more through holes can be respectively provided at the two ends of the short side of the mounting seat 40, and a corresponding number of threaded holes are provided at corresponding positions of the reagent compartment housing 10, and the mounting seat 40 is fixed to the reagent compartment housing 10 by screws or bolts.

[0029] Figure 2 is a three-dimensional diagram of a reagent kit automatic loading device with an additional cover plate according to an embodiment of the present application, Figure 3 is a schematic diagram of the structure of the cover plate according to an embodiment of the present application. Figure 2 , Figure 3 As shown, in some embodiments, a cover plate 11 is provided between the reagent compartment housing 10 and the mounting seat 40, and the cover plate 11 can be overlapped on the reagent compartment housing 10, and the mounting seat 40 is fixedly connected to the cover plate 11. A plurality of windows can be provided on the cover plate 11 according to actual needs, and can include one or more of a pick-and-place component replacement window 110, a manual replacement window 111, or a reagent extraction port 112, wherein the pick-and-place component replacement window 110 is used for the pick-and-place component 30 to replace the reagent kit, the manual replacement window 111 is used for manual replacement of the reagent kit, and the reagent extraction port 112 is used for the liquid addition needle to extract the reagent in the reagent kit, and the windows can be opened separately or jointly.

[0030] Figure 4 Schematic diagram of the structure of the reagent kit carrier and the mounting seat according to the embodiment of the present application. Figure 4 Combined with Figure 1 As shown, a reagent kit carrier 41 is rotatably mounted on the mounting seat 40, and the reagent kit carrier 41 is concentrically arranged with the turntable 20. A plurality of second card slots 410 are arranged on the reagent kit carrier 41, at least one of which is used to place a first reagent kit 51 and at least one of which is used to place a second reagent kit 52. The first card slot 21 is located below the second card slot 410 and the two can overlap each other in the vertical direction.

[0031] Furthermore, the reagent kit carrier 41 may be circular, fan-shaped or elongated. In some embodiments, Figure 4 As shown, the reagent kit carrier 41 is in the shape of a duck web, wherein the web surface is arranged away from the center position, and a plurality of second slots 410 are arranged on the web surface.

[0032] Figure 5 1 is an assembly diagram of a drive assembly and a reagent kit carrier according to an embodiment of the present application. Figure 4 , Figure 5 As shown, the mounting seat 40 is also provided with a driving assembly 60 for driving the reagent kit carrier 41 to rotate relative to the center of the reagent compartment housing 10. In some embodiments, the driving assembly 60 includes a driving motor 61, which provides power to drive the reagent kit carrier 41 to rotate, which can be in the form of a gear or a pulley between the reagent kit carrier 41 and the mounting seat 40, and a gear or a belt is correspondingly provided on the output shaft of the driving motor 61 to transmit power; in one embodiment, a cross-stick bearing 62 is provided on the mounting seat 40, and a pulley 63 is concentrically provided on the rotatable portion thereof, and the reagent kit carrier 41 is concentrically provided on the pulley 63; a belt 64 is sleeved on the output end of the driving motor 61, and the other end of the belt 64 is sleeved on the outer circumference of the pulley 63.

[0033] Figure 6 is a schematic diagram of the structure of the zero-position optical coupler and the baffle according to an embodiment of the present application. Figure 4-6 As shown, in some embodiments, the driving assembly 60 includes a zero-position optical coupler 65, and a baffle 66 is provided below the reagent kit carrier 41. The baffle 66 rotates synchronously with the reagent kit carrier 41. When the baffle 66 is located at the zero-position optical coupler 65 position, it is determined that the reagent kit carrier 41 is at the zero position at this time, and the control assembly sets the rotation angle of the reagent kit carrier 41 according to the zero position. In one embodiment, four second card slots 410 are provided on the reagent kit carrier 41, which are the first to fourth second card slots in clockwise order. The baffle 66 can be provided. When the second card slot 1 is located below the gripper 31, the baffle 66 blocks the light of the zero-position optical coupler 65 to form an electrical signal to determine that the position of the reagent kit carrier 41 is the zero position at this time, and the rotation angle of the reagent kit carrier 41 is set accordingly, including the angle at which the first second card slot rotates clockwise to make the reagent kit carrier 41 in a safe position, the angle when the second to fourth second card slots are respectively located below the gripper 31, etc.

[0034] Figure 7 is a schematic diagram of the structure of a pick-and-place assembly according to an embodiment of the present application. Figure 1 , Figure 7As shown, the pick-and-place assembly 30 includes a gripper 31 located above the first card slot 21 and the second card slot 410. In some embodiments, the pick-and-place assembly 30 includes a motor bracket 32 ​​vertically placed on the side of the reagent compartment housing 10, and a motor (not shown in the figure) and a mounting bracket 33 are installed on the motor bracket 32. The motor can be installed at the bottom end of the motor bracket 32, one end of the mounting bracket 33 is vertically connected to the motor bracket 32 ​​and can slide and rise on the motor bracket 32, and the other end of the mounting bracket 33 is fixedly connected to the gripper 31. The motor operation is controlled by the control assembly, so that the mounting bracket 33 drives the gripper 31 to rise and fall vertically.

[0035] Combination Figure 1 , Figure 4 , Figure 7 As shown, the control component also controls the grabbing and placing actions of the gripper 31. When there is a first reagent kit (not shown in the figure) on the first card slot 21 that needs to be replaced, the gripper 31 is controlled to grab the first reagent kit 51 and place it on the second card slot 410, and then grab the second reagent kit 52 for replacement on the reagent kit carrier 41 and place it on the first card slot 21. In one embodiment, the number of second card slots 410 is 4, of which 3 are used to place second reagent kits 52 and 1 is used to place first reagent kits 51, which are numbered as the first to fourth second card slots respectively. In the initial state, the second reagent kits 52 are placed in the first to third second card slots, and the fourth second card slot is left empty without a reagent kit. When the first reagent kit 51 in the first card slot 21 on the turntable 20 needs to be replaced, the gripper 31 is controlled to grab the first reagent kit 51 and place it on the fourth second card slot, and then grab the corresponding second reagent kits 52 on the first to third second card slots and place them in the first card slot 21 where the original first reagent kit 51 is located. The first reagent kit 51 on the fourth second card slot can be manually discarded for the next replacement operation. When the first to third second card slots are all controlled, a new second reagent kit 52 is manually placed.

[0036] According to the automatic reagent kit loading device provided in the embodiment of the present application, the reagent kit can be replaced without stopping the machine, which effectively improves the replacement efficiency of the reagent kit and ensures the continuous operation of the chemiluminescence immunoassay analyzer.

[0037] Figure 8 is a schematic diagram of the structure of the identification component according to an embodiment of the present application. Figure 1 , Figure 8As shown, in some embodiments, an identification component 70 is provided on the circumferential edge of the reagent compartment housing 10, and the identification component 70 includes a barcode scanner 71 and a reflective optical coupler 72. The reagent kit has a unique identity. When the reagent kit is placed on the second card slot 410, the barcode scanner 71 reads its unique identity, and the reflective optical coupler 72 confirms whether there is a reagent kit on the second card slot 410, and sends a signal to the control component. The unique identity on the reagent kit can be a barcode or a QR code, on which the relevant information of the reagent bottle on the reagent kit can be recorded, and the information can include one or more of the reagent name, production batch, production date, expiration date, product serial number or supplier information in the reagent bottle, wherein the reagent name refers to the main component or functional description of the reagent for easy identification and use; the production batch refers to the batch number of the reagent production, which can be used to track the source and quality control of the product; the production date and expiration date can help users know the freshness and validity period of the reagent to ensure the accuracy of the experimental results; the product serial number refers to the unique number of the reagent, which can be used to track the production and sales of the product; the supplier information includes the information of the manufacturer or supplier of the reagent, such as the company name, address, etc. The reflective optical coupler 72 detects the presence of the corresponding reagent kit by emitting a light source, receiving a reflected light source, and converting photoelectric signals.

[0038] In some embodiments, a barcode scanner and / or a reflective optical coupler are also provided on the side of the reagent compartment shell 10, wherein the barcode scanner is used to identify the information of the reagent kit placed in the first card slot, and the reflective optical coupler is used to detect whether there is a reagent kit in the first card slot, and accurate replacement of the same type of reagent kit is achieved by cooperating with the identification component provided on the peripheral edge of the reagent compartment shell.

[0039] The present application also proposes a chemiluminescent immunoassay analyzer, including a liquid adding needle and a reagent mixing device, wherein the reagent mixing device includes a reagent kit automatic loading device as described above, and the reagent mixing device is used to mix the reagent in the reagent bottle so that the liquid adding needle draws the mixed reagent to a predetermined position. The chemiluminescent immunoassay analyzer proposed in the embodiment of the present application includes a reagent mixing device including a reagent kit automatic loading device, which can complete the replacement of the reagent kit without stopping the machine and mix the reagents used in the analyzer, and can use the reagent needle to draw the mixed reagent into the reaction tube.

[0040] The above embodiments are only used to illustrate the present invention, but not to limit the present invention. Ordinary technicians in the relevant technical field can make various changes and modifications without departing from the scope of the present invention. Therefore, all equivalent technical solutions should also fall within the scope of the present invention.

Claims

1. A reagent box automatic loading device, comprising a circular reagent compartment housing and a control component, wherein a turntable is concentrically arranged inside the reagent compartment housing, and a pick-and-place component is arranged outside the reagent compartment housing, characterized in that: A plurality of first slots are arranged on the circumferential edge of the rotating disk; An elongated mounting seat is provided above the reagent compartment housing on one side facing the pick-and-place assembly, and two ends of the short side of the mounting seat are respectively fixedly connected to the circumferential edge of the reagent compartment housing in any one diameter direction; A reagent kit carrier is rotatably mounted on the mounting seat, the reagent kit carrier is concentrically arranged with the turntable, and a plurality of second card slots are arranged on the reagent kit carrier, at least one of which is used to place a first reagent kit and at least one of which is used to place a second reagent kit, the first card slot is located below the second card slot and the two can overlap each other in the vertical direction; The mounting seat is also provided with a driving assembly for driving the reagent kit carrier to rotate relative to the center of the reagent compartment housing; The pick-and-place component includes a gripper located above the first card slot and the second card slot, and the control component controls the vertical lifting and lowering movement of the gripper; when a first reagent kit needs to be replaced on the first card slot, the gripper is controlled to grab the first reagent kit and place it on the second card slot, and then grab the second reagent kit for replacement on the reagent kit carrier and place it on the first card slot.

2. The automatic reagent kit loading device according to claim 1, characterized in that: An identification component is arranged on the circumferential edge of the reagent compartment shell, and the identification component includes a barcode scanner and a reflective optical coupler. The reagent kit is provided with a unique identity tag. When the reagent kit is placed on the second card slot, the barcode scanner reads the identity tag, and the reflective optical coupler confirms whether there is a reagent kit on the second card slot and sends a signal to the control component.

3. The automatic reagent kit loading device according to claim 1, characterized in that: The reagent compartment housing is provided with a cover plate, and the cover plate is located between the first card slot and the second card slot.

4. The automatic reagent kit loading device according to claim 3, characterized in that: The cover plate is provided with a window for facilitating replacement of the pick-and-place component, and the window is located below the pick-and-place component.

5. The automatic reagent kit loading device according to claim 4, characterized in that: The cover plate is also provided with a manual replacement window for manually replacing the reagent kit.

6. The automatic reagent kit loading device according to claim 4, characterized in that: The cover plate is also provided with a reagent extraction port for a liquid adding needle to extract the reagent in the reagent box.

7. The automatic reagent kit loading device according to claim 4, characterized in that: The number of the second card slots is 4, of which 1 is used to place the first reagent kit and 3 are used to place the second reagent kit.

8. The automatic reagent kit loading device according to claim 1, characterized in that: The driving assembly includes a driving motor; a cross-stick bearing is arranged on the mounting seat, a pulley is arranged concentrically on the rotatable portion thereof, and the reagent kit carrier is arranged concentrically on the pulley; a belt is sleeved on the output end of the driving motor, and the other end of the belt is sleeved on the outer circumference of the pulley.

9. The automatic reagent kit loading device according to claim 1, characterized in that: The driving component includes a zero-position optical coupler, and a baffle is arranged under the reagent kit carrier. The baffle rotates synchronously with the reagent kit carrier. When the baffle is located at the zero-position optical coupler position, it is determined that the reagent kit carrier is at the zero position at this time. The control component sets the rotation angle of the reagent kit carrier according to the zero position.

10. A chemiluminescent immunoassay analyzer, comprising a liquid adding needle and a reagent mixing device, characterized in that: The reagent mixing device comprises the automatic reagent kit loading device as described in any one of claims 1 to 9, the reagent kit is equipped with a reagent bottle, and the reagent mixing device is used to mix the reagent in the reagent bottle so that the liquid adding needle draws the mixed reagent to a predetermined position.

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