In-situ hybridization instrument

Abstract

The utility model discloses an in-situ hybridization instrument and relates to the technical field of detection equipment. The food processor comprises a machine body, a rotating plate is rotationally installed on one face of the machine body, a heating plate is fixedly installed on the inner bottom wall of the machine body through screws, and a containing plate is arranged in the machine body. According to the utility model, the heating plate is arranged on the inner bottom wall of the machine body and is used for providing a constant temperature environment so as to promote the hybridization reaction between a probe and a target sequence. The heating plate has an adjustable temperature range to adapt to different experiment requirements so as to meet the requirements of users, and through a limiting piece fixedly installed on the placing plate and a pressing plate constructed on the rotating plate, when a temporary loading piece is placed, the temporary loading piece can be effectively fixed, so that the use is convenient. The in-situ hybridization device solves the problems that when a temporary loading piece is placed in an existing in-situ hybridization device, the temporary loading piece is generally fixed through a pressing plate, the fixing mode is unstable, the loading piece can be inexpensive during hybridization, and the test result is influenced.

Description

Technical Field

[0001] The utility model relates to the technical field of detection equipment, in particular to an in situ hybridization instrument. Background Art

[0002] An in situ hybridization instrument is an instrument used to perform in situ hybridization experiments. In situ hybridization is a molecular biology technique that complementarily pairs molecules labeled with specific DNA or RNA probes with target nucleic acid sequences in cells or tissue samples to be tested to study the location, expression, and quantification of target sequences. As a device specifically used to perform in situ hybridization experiments, the in situ hybridization instrument provides a precise and reliable control and detection system to help researchers conduct high-quality experiments. When placing temporary slides inside existing in situ hybridization instruments, they are generally fixed by a pressing plate, and the fixing method is not stable. During hybridization, the slides may be offset, which may affect the test results. Utility Model Content

[0003] In order to achieve the above-mentioned purpose, the utility model specifically adopts the following technical solutions:

[0004] An in situ hybridization instrument comprises a body, characterized in that a rotating plate is rotatably mounted on one side of the body, a heating plate is fixedly mounted on the inner bottom wall of the body by screws, and a placement plate is structured inside the body.

[0005] Furthermore, the placement plate is placed on the machine body, a plurality of placement grooves are provided on the surface of the placement plate, the placement grooves are used to place temporary films, a pressure plate is installed at the position where the rotating plate is opposite to the placement grooves, and a limiting plate is fixedly installed on the placement plate.

[0006] Furthermore, a plurality of fixed blocks are fixedly installed at the end of the body, a rotating rod is constructed between the fixed blocks, the rotating rod is fixedly connected to the fixed block and is rotatably connected to the rotating plate, and the rotating plate can be rotatably connected to the body by means of the rotating rod.

[0007] Furthermore, a display screen is fixedly mounted on one side of the body away from the fixed block, a control button is fixedly mounted next to the display screen, and the display screen is electrically connected to the control button.

[0008] Furthermore, a non-slip rubber pad is fixedly installed on the bottom of the body, and the non-slip rubber pad is used to increase the friction between the body and the desktop.

[0009] Furthermore, lifting plates are fixedly installed on both sides of the rotating plate.

[0010] The beneficial effects of the utility model are as follows:

[0011] 1. The utility model provides a constant temperature environment by arranging a heating plate on the bottom wall of the body to promote the hybridization reaction between the probe and the target sequence. The heating plate has an adjustable temperature range to adapt to different experimental requirements to meet the needs of users.

[0012] 2. The utility model can effectively fix the temporary slide when placing it by means of a restriction plate fixedly installed on the placement plate and a pressure plate constructed on the rotating plate, thereby solving the problem that the existing in situ hybridization instrument generally fixes the temporary slide by a pressure plate when placing the temporary slide inside, and the fixing method is not stable, which may cause the slide to shift during hybridization and affect the test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a three-dimensional structural schematic diagram of the utility model;

[0014] Figure 2 It is the internal diagram of the three-dimensional structure of the utility model;

[0015] Figure 3 This is a three-dimensional structural schematic diagram of the utility model from another viewing angle;

[0016] Figure numerals: 1, machine body; 2, rotating plate; 3, heating plate; 4, placement plate; 5, placement groove; 6, pressure plate; 7, limiting plate; 8, fixing block; 9, rotating rod; 10, display screen; 11, control button; 12, anti-slip rubber pad; 13, lifting plate. DETAILED DESCRIPTION

[0017] In order to make the purpose, technical solution and advantages of the embodiments of the present utility model clearer, the technical solution in the embodiments of the present utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the present utility model.

[0018] The present application provides an in situ hybridization instrument, which is mainly used to solve the problem that when a temporary slide is placed inside the existing in situ hybridization instrument, it is generally fixed by a pressing plate 6, and its fixing method is not stable. During hybridization, the slide may be offset, which affects the test results, and the following technical solutions are provided. Figure 1-Figure 3 Make a detailed description:

[0019] An in situ hybridization instrument comprises a body 1, a rotating plate 2 is rotatably mounted on one side of the body 1, a heating plate 3 is fixedly mounted on the inner bottom wall of the body 1 by screws, a placement plate 4 is structured inside the body 1, the placement plate 4 is clamped on the body 1, a plurality of placement grooves 5 are opened on the surface of the placement plate 4, the placement grooves 5 are used to place temporary slides, a pressing plate 6 is correspondingly mounted at the position opposite to the rotation plate 2 and the placement grooves 5, a limiting plate 7 is also fixedly mounted on the placement plate 4, a plurality of groups of fixed blocks 8 are fixedly mounted on the end of the body 1, a rotating rod 9 is constructed between the fixed blocks 8, the rotating rod 9 is fixedly connected to the fixed blocks 8 and is rotatably connected to the rotating plate 2, the rotating plate 2 can be rotatably connected to the body 1 by relying on the rotating rod 9, a display screen 10 is fixedly mounted on the side of the body 1 away from the fixed blocks 8, a control button 11 is fixedly mounted next to the display screen 10, the display screen 10 is electrically connected to the control button 11, and an anti-slip Rubber pad 12, non-slip rubber pad 12 is used to increase the friction between the body 1 and the desktop, lifting plates 13 are fixedly installed on both sides of the rotating plate 2. In some embodiments, first place the hand on the lifting plate 13, lift the lifting plate 13 to drive the rotating plate 2 to move, the rotating plate 2 is rotated by the rotating rod 9, at this time, the temporary mount is inserted obliquely into the placement groove 5 from away from the limiting plate 7, and then all the temporary mounts are placed in the placement groove 5, one end of the temporary mount is also fixed by the limiting plate 7, after the temporary mount is fixed, press the lifting plate 13 to rotate the rotating plate 2 toward the body 1, and press the pressing plate 6 to the temporary mount, further fix the temporary mount and prevent the mount from moving. Since the control button 11 is electrically connected to the heating plate 3, the temperature of the heating plate 3 can be controlled by pressing the control button 11 to provide a constant temperature environment to promote the hybridization reaction between the probe and the target sequence. The heating plate 3 has an adjustable temperature range to adapt to different experimental requirements to meet the needs of users. The in situ hybridization instrument can detect changes in the number and structure of chromosomes / genes in lymphoma, leukemia and other various solid tumor cells, including chromosome translocation, aneuploidy changes, gene deletion, amplification and other molecular genetic changes, and provide accurate molecular genetic information for the diagnosis, classification, targeted treatment and prognosis prediction of diseases in clinical pathology work. It solves the problem that when a temporary slide is placed inside the existing in situ hybridization instrument, it is generally fixed by a pressing plate 6, and its fixing method is not stable. During hybridization, it may cause the slide to shift, which affects the test results.

[0020] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An in situ hybridization apparatus, comprising a body (1), characterized in that: A rotating plate (2) is rotatably mounted on one side of the machine body (1), a heating plate (3) is fixedly mounted on the inner bottom wall of the machine body (1) by screws, and a placement plate (4) is structured inside the machine body (1); The placement plate (4) is clamped on the machine body (1), and a plurality of placement grooves (5) are provided on the surface of the placement plate (4). The placement grooves (5) are used to place temporary mounted films, and a pressing plate (6) is correspondingly installed at the position where the rotating plate (2) is opposite to the placement grooves (5). A limiting plate (7) is also fixedly installed on the placement plate (4).

2. An in situ hybridization instrument according to claim 1, characterized in that: A plurality of fixed blocks (8) are fixedly mounted on the ends of the machine body (1), and a rotating rod (9) is constructed between the fixed blocks (8). The rotating rod (9) is fixedly connected to the fixed blocks (8) and is rotatably connected to the rotating plate (2). The rotating plate (2) can be rotatably connected to the machine body (1) by means of the rotating rod (9).

3. An in situ hybridization instrument according to claim 1, characterized in that: A display screen (10) is fixedly mounted on one side of the machine body (1) away from the fixed block (8), a control button (11) is fixedly mounted next to the display screen (10), and the display screen (10) is electrically connected to the control button (11).

4. An in situ hybridization instrument according to claim 1, characterized in that: An anti-skid rubber pad (12) is fixedly mounted on the bottom of the machine body (1), and the anti-skid rubber pad (12) is used to increase the friction between the machine body (1) and the desktop.

5. An in situ hybridization instrument according to claim 1, characterized in that: Lifting plates (13) are fixedly mounted on both sides of the rotating plate (2).

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