Multi-mode-based electric pulse ablation equipment

Abstract

The utility model provides a multi-mode-based electric pulse ablation device. The multi-mode-based electric pulse ablation device comprises an output circuit providing a controllable pulse sequence; a path switching device provided with a plurality of electrodes enables a selected electrode to receive a specified pulse sequence; the data acquisition device acquires electrode signals of the plurality of electrodes and converts the electrode signals into digital signals; the control device comprises a master controller and at least one slave controller; the master controller controls all the slave controllers; and the slave controller is in communication connection with the output circuit, the access switching device and the data acquisition device, controls the output circuit and the access switching device, and receives the digital signal. Thus, switching of various different electrodes can be achieved, meanwhile, the provided pulse sequences can be changed, the connected electrodes can obtain different pulse sequences, and then switching of various modal functions can be flexibly and conveniently achieved on one electric pulse ablation device; the problem of how to conveniently and flexibly use multiple modal functions in single ablation treatment is solved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, and in particular to a multi-modal electric pulse ablation device. Background Art

[0002] Ablation technology is a minimally invasive treatment option that can be used to treat some tumors. When performing tumor ablation, appropriate invasive means and ablation size should be used to destroy the entire tumor while minimizing the impact on the normal tissue and structure around the tumor, and to avoid the spread of tumor cells or damage to tissues when the tumor leaves the human body.

[0003] In the prior art, a single-function ablation device is usually used for ablation therapy in a single treatment, such as irreversible electroporation device, radiofrequency ablation device, microwave ablation device, electrocautery device or ultrasonic ablation device, etc. However, in the actual ablation treatment process, the shape, size, boundary accuracy of the ablation area, the effect of tumor ablation and the impact of the invasive method on the surrounding tissue are all restricted by the single-function ablation device, making the effect of a single ablation treatment unsatisfactory.

[0004] Medical research has shown that the combination of multiple modalities can significantly improve the adaptability of tumor ablation, treatment safety, treatment effect, and the ability to activate the immune system response after surgery. However, existing equipment is mainly single-modality equipment, and the working specifications of each device are different, making it difficult to integrate. Although there are some multi-modality devices, their modal functions are usually relatively few, and they are all pre-set modes without combination flexibility. Therefore, if you want to use multiple modalities for ablation in a single compatible treatment, you usually need to equip yourself with multiple single-modality devices. This stacking of multiple devices will lead to a reduction in equipment circulation utilization and cause a lot of resource waste. Utility Model Content

[0005] The purpose of the utility model is to provide a multi-modality-based electric pulse ablation device, so as to at least solve the problem of how to conveniently and flexibly use multiple modality functions in a single ablation treatment.

[0006] In order to solve the above technical problems, the utility model provides a multi-modal electric pulse ablation device, comprising:

[0007] an output circuit for providing a controllable pulse train;

[0008] a path switching device, configured with a plurality of electrodes, the path switching device being used to switch the electrodes so that the selected electrodes receive the designated pulse sequence;

[0009] A data acquisition device, used for acquiring electrode signals of a plurality of electrodes and converting the acquired electrode signals into digital signals;

[0010] The control device includes a master controller and at least one slave controller; the master controller is used to control the operation of all the slave controllers; the slave controller is communicatively connected with the output circuit, the path switching device and the data acquisition device to control the output circuit and the path switching device, and receive digital signals from the data acquisition device.

[0011] Optionally, in the multimodal electric pulse ablation device, the output circuit includes two ablation drive circuits; each ablation drive circuit includes an indicator diode, a first switch, a switching control circuit and a second switch connected in sequence, and a high-voltage pulse capacitor is connected to the end of the second switch and the end of the first switch close to the diode; the switching control circuits in the two ablation drive circuits are connected in an H-bridge form, and the two switching control circuits respectively lead out a first pulse output terminal and a second pulse output terminal, and the connection loop of the two ablation drive circuits is changed by controlling the on-off state of the two switching control circuits, thereby changing the pulses output by the first pulse output terminal and the second pulse output terminal.

[0012] Optionally, in the multi-modality-based electric pulse ablation device, the switching control circuit includes two parallel branches, each branch has two switching switches connected in series, and a connecting node is led out between the two switching switches; the connecting node on one branch of one of the switching control circuits is connected to the connecting node on one branch of another of the switching control circuits; the connecting node on the other branch leads to the first pulse output end, and the connecting node on the other branch of the other switching control circuit leads to the second pulse output end.

[0013] Optionally, in the multi-modal electric pulse ablation device, the switching control circuit also includes a voltage equalizing circuit, which includes two transistor units connected in series; each transistor unit includes a transistor, a diode, a first resistor, a second resistor and a capacitor; the source of the transistor is respectively connected to the positive electrode of the diode, one end of the first resistor and one end of the second resistor, the cathode of the diode is respectively connected to the other end of the first resistor and the positive electrode of the capacitor, and the cathode of the capacitor is respectively connected to the other end of the second resistor and the drain of the transistor; the drain of the transistor of one transistor unit is connected to the source of the transistor of the other transistor unit.

[0014] Optionally, in the multimodal electric pulse ablation device, the output circuit also includes a high-voltage power supply; the high-voltage power supply is used to power the ablation drive circuit; the high-voltage power supply includes an AC input terminal and a high-voltage output terminal, the live wire of the AC input terminal is connected to the live wire of the high-voltage output terminal, and the neutral wire of the AC input terminal is connected to the neutral wire of the high-voltage output terminal; between the live wire and the neutral wire, a power supply capacitor, a power supply resistor and a power supply transformer are connected in parallel.

[0015] Optionally, in the multi-modality-based electric pulse ablation device, a safety switch and a fuse are provided on the live wire and / or the neutral wire.

[0016] Optionally, in the multi-modality-based electric pulse ablation device, the output circuit further includes a high voltage manager; the high voltage manager is used to control the supply of power from the high voltage power supply to the ablation drive circuit.

[0017] Optionally, in the multi-modality-based electric pulse ablation device, the output circuit further includes a current protection circuit; the current protection circuit is used to perform overload protection on the output circuit when the current of the output pulse sequence exceeds a threshold value.

[0018] Optionally, in the multi-modality-based electric pulse ablation device, the pathway switching device has a plurality of switching connection points, and each electrode is respectively connected to one of the switching connection points.

[0019] Optionally, in the multimodal electric pulse ablation device, the data acquisition device includes a multi-channel signal input channel, an analog-to-digital converter, a memory and a controller; the multi-channel signal input channel is respectively communicated with a plurality of electrodes one by one to obtain the electrode signal of each electrode; the analog-to-digital converter is used to convert the acquired electrode signal into a digital signal; the memory is used to store the converted digital signal; the controller is communicated with the slave controller, and is used to control the operation of the data acquisition device under the control of the slave controller, and send the digital signal to the slave controller.

[0020] Optionally, in the multimodal electric pulse ablation device, the main controller includes a human-computer interaction interface, and instructions are issued through the human-computer interaction interface so that the slave controller controls the output circuit and the path switching device according to the instructions, or receives digital signals from the data acquisition device.

[0021] The utility model provides a multi-modal electric pulse ablation device, comprising: an output circuit for providing a controllable pulse sequence; a path switching device, configured with a plurality of electrodes, the path switching device for switching each electrode so that the selected electrode receives a specified pulse sequence; a data acquisition device for acquiring electrode signals of the plurality of electrodes and converting the acquired electrode signals into digital signals; a control device, comprising a master controller and at least one slave controller; the master controller is used to control the operation of all the slave controllers; the slave controller is connected in communication with the output circuit, the path switching device and the data acquisition device to control the output circuit and the path switching device, and receive digital signals from the data acquisition device. By controlling the control of the path switching device by the master controller, the plurality of slave controllers can be flexibly switched to the plurality of electrodes, and the master controller can also be used to control the control of the output circuit by the plurality of slave controllers to change the pulse sequence provided, so that the connected electrodes can obtain different pulse sequences, and thus the switching of the plurality of modal functions can be flexibly and conveniently realized on a single electric pulse ablation device, solving the problem of how to conveniently and flexibly use the plurality of modal functions in a single ablation treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 A schematic diagram of the structure of a multi-modal electric pulse ablation device provided in this embodiment;

[0023] Figure 2 A schematic diagram of the circuit structure of the ablation driving circuit provided in this embodiment;

[0024] Figure 3 A schematic diagram of a specific output circuit structure provided in this embodiment;

[0025] Figure 4 A schematic diagram of the circuit structure of the voltage balancing circuit provided in this embodiment;

[0026] Figure 5 A schematic diagram of the circuit structure of the high voltage power supply provided in this embodiment;

[0027] Figure 6 A schematic diagram of the functional design of the high voltage manager provided in this embodiment;

[0028] Figure 7 A schematic diagram of the circuit structure of the current protection circuit provided in this embodiment;

[0029] Figure 8 A schematic diagram of the structure of the pulse release end of the electric pulse ablation device provided in this embodiment;

[0030] Fig. 9 A schematic diagram of the internal structure connection of the multi-modal electric pulse ablation device provided in this embodiment;

[0031] Fig.10 A design diagram of the control device provided for this embodiment;

[0032] The symbols in the figure are described as follows:

[0033] 110 - pulse release needle; 120 - handheld part; 130 - electrode connector; 140 - pipeline. DETAILED DESCRIPTION

[0034] The following is a further detailed description of the multimodal electric pulse ablation device proposed by the utility model in combination with the accompanying drawings and specific embodiments. It should be noted that the accompanying drawings are all in a very simplified form and use non-precise proportions, which are only used to conveniently and clearly assist in explaining the purpose of the embodiments of the utility model. In addition, the structure shown in the accompanying drawings is often a part of the actual structure. In particular, the emphasis that each drawing needs to show is different, and sometimes different proportions are used.

[0035] It should be noted that the "first", "second" and the like in the specification, claims and drawings of the utility model are used to distinguish similar objects in order to describe the embodiments of the utility model, and are not used to describe a specific order or sequence. It should be understood that the structures used in this way can be interchanged under appropriate circumstances. In addition, the terms "including" and "having" and any of their variations are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0036] This embodiment provides a multi-modal electric pulse ablation device, such as Figure 1 As shown, it includes: an output circuit for providing a controllable pulse sequence; a path switching device, which is configured with multiple electrodes, and the path switching device is used to switch each electrode so that the selected electrode receives a specified pulse sequence; a data acquisition device, which is used to collect electrode signals of multiple electrodes and convert the collected electrode signals into digital signals; a control device, including a master controller and at least one slave controller; the master controller is used to control the operation of all the slave controllers; the slave controller is communicatively connected with the output circuit, the path switching device and the data acquisition device to control the output circuit and the path switching device, and receive digital signals from the data acquisition device.

[0037] The multi-modal electric pulse ablation device provided in this embodiment can realize flexible switching of multiple electrodes by controlling the control of the path switching device by multiple slave controllers through the master controller. At the same time, the master controller can also be used to control the control output circuit by multiple slave controllers to change the provided pulse sequence so that the connected electrodes can obtain different pulse sequences, thereby being able to flexibly and conveniently realize switching of multiple modal functions on one electric pulse ablation device, solving the problem of how to conveniently and flexibly use multiple modal functions in a single ablation treatment.

[0038] Specifically, in this embodiment, the output circuit includes two ablation drive circuits. Figure 2 As shown, each ablation drive circuit includes an indicating diode D11 / D21, a first switch S11 / S21, a switching control circuit and a second switch S12 / S22 connected in sequence, and a high-voltage pulse capacitor C11 / C21 is connected to the end of the second switch S12 / S22 and the end of the first switch S11 / S21 close to the diode D11 / D21.

[0039] In order to enable the output circuit to provide a pulse sequence, in this embodiment, the switching control circuits in the two ablation drive circuits are connected in an H-bridge manner, and the two switching control circuits lead out a first pulse output terminal and a second pulse output terminal respectively, and the connection loop of the two ablation drive circuits is changed by controlling the on-off state of the two switching control circuits, thereby changing the pulses output by the first pulse output terminal and the second pulse output terminal. Figure 2 As shown, the switching control circuit 1 leads to a first pulse output terminal UU, and the switching control circuit 2 leads to a second pulse output terminal VV.

[0040] Furthermore, in this embodiment, if Figure 3 As shown, the switching control circuit includes two parallel branches, each branch has two switching switches connected in series, and a connecting node is led out between the two switching switches; the connecting node on one branch of one of the switching control circuits is connected to the connecting node on one branch of another switching control circuit; the connecting node on the other branch leads to the first pulse output end, and the connecting node on the other branch of the other switching control circuit leads to the second pulse output end.

[0041] In practical applications, the switching switch includes a transistor and a diode connected in parallel, so that the circuit can be turned on and off according to the voltage at both ends of the switching switch, thereby realizing the function of the switch. Among them, the transistor can be a MOSFET, IGBT, SiC or other components, and this application does not limit this, as long as the switch function can be realized.

[0042] In this way, the switching control circuits in the two ablation drive circuits form an H-bridge. By controlling the switching switch state corresponding to each H-bridge, the direction of the current and whether it flows through the load can be determined; by controlling the on and off of the transistor switches on the H-bridge, a controllable pulse sequence can be formed.

[0043] Preferably, in order to ensure the uniformity of voltage sharing among the transistors in the switching switch on the H-bridge, in this embodiment, the switching control circuit further includes a voltage balancing circuit, such as Figure 4 As shown, the voltage balancing circuit includes two transistor units connected in series; each transistor unit includes a transistor T1 / T2, a diode D31 / D32, a first resistor R11 / R21, a second resistor R12 / R22 and a capacitor C31 / C32; the source of the transistor T1 / T2 is respectively connected to the positive electrode of the diode D31 / D32, one end of the first resistor R11 / R21 and one end of the second resistor R12 / R22, the negative electrode of the diode D31 / D32 is respectively connected to the other end of the first resistor R11 / R21 and the positive electrode of the capacitor C31 / C32, the negative electrode of the capacitor C31 / C32 is respectively connected to the other end of the second resistor R12 / R22 and the drain of the transistor T1 / T2; the drain of the transistor T1 of one transistor unit is connected to the source of the transistor T2 of the other transistor unit.

[0044] In a specific embodiment, if Figure 3 As shown, the output circuit also includes an industrial frequency transformer, an AC / DC converter, a high voltage power supply, and a high voltage manager, etc. The industrial frequency transformer and the AC / DC converter are widely used in power supplies, wherein the industrial frequency transformer generally refers to a transformer that can change the voltage of AC power at the mains frequency. Specifically, the industrial frequency transformer can convert high voltage power into mains power for use in power pulse ablation equipment; the AC / DC converter is used to convert AC power into DC power for use in modules that require DC power in the power pulse ablation equipment; the high voltage manager is used to control and interact with the AC / DC converter, the high voltage power supply, the high voltage pulse capacitor, the first switch, and the second switch, so as to achieve the output of different pulse sequences.

[0045] Wherein, the high voltage power supply is used to supply power to the ablation drive circuit. Figure 5 As shown, the high-voltage power supply includes an AC input terminal (the voltage between the live wire L and the neutral wire N is AC 220V) and a high-voltage output terminal (live wire LO and neutral wire NO), the live wire L of the AC input terminal is connected to the live wire LO of the high-voltage output terminal, and the neutral wire N of the AC input terminal is connected to the neutral wire NO of the high-voltage output terminal; between the live wire and the neutral wire, a power supply capacitor C4, a power supply resistor R3 and a power supply transformer L11 / L12 are connected in parallel. In this way, the output voltage and current meet the working voltage and current of the electric pulse ablation device.

[0046] Preferably, in order to ensure the safety of the high voltage power supply, in this embodiment, Figure 5 As shown, a safety switch and a fuse are provided on the live wire and / or the neutral wire. In this way, when the load is too high, the fuse will be blown, thereby cutting off the power supply to protect the power supply safety of the electric pulse ablation device; or, when the high voltage manager detects that the high voltage power supply is abnormal, it can control the on and off of the safety switch to ensure the power supply safety of the electric pulse ablation device.

[0047] And, the high voltage manager is used to control the high voltage power supply to supply power to the ablation drive circuit, specifically, as Figure 3 As shown, the high-voltage manager controls the output of the AC-DC converter and receives feedback information from the AC-DC converter, controls and samples the high-voltage power supply to ensure safe use and normal power supply of the high-voltage voltage, samples the high-voltage pulse capacitor, controls the first switch and the second switch and receives feedback information from the first switch and the second switch.

[0048] Specifically, Figure 6 As shown, the high-voltage manager inputs a high-voltage power supply; the high-voltage manager can drive the charging switch circuit (first switch) and the discharging switch circuit (second switch) and receive their state feedback; a voltage sampling circuit is provided in the high-voltage manager for sampling the high-voltage pulse capacitor; the high-voltage manager outputs to the ablation drive circuit, thereby driving the ablation drive circuit to generate a pulse sequence.

[0049] Preferably, in order to ensure the safety of the output circuit, in this embodiment, the output circuit further includes a current protection circuit; the current protection circuit is used to protect the output circuit from overload when the current of the output pulse sequence exceeds a threshold value. This embodiment provides a specific circuit structure of the current protection circuit as shown in FIG. Figure 7 As shown, the current protection circuit can protect the output circuit from power failure when the output current exceeds 10 A. Of course, in other embodiments, different current protection circuits can be set according to actual needs to protect the output circuit under currents exceeding different protection thresholds, and this application does not limit this.

[0050] Furthermore, in this embodiment, the path switching device has a plurality of switching connection points, and each electrode is respectively connected to one of the switching connection points.

[0051] Specifically, the path switching device can be a selector switch, so that under the control of the control device, the selector switch selects one of the branches to be turned on; or, the path switching device can be a plurality of single-pole single-throw switches (relays) connected in parallel, so that under the control of the control device, a single-pole single-throw switch is selected to be closed to turn on the branch. Of course, there can be many specific implementation schemes of the path switching device, and the above two are only examples of possible implementation methods, but the protection scope of this application is not limited to this. Those skilled in the art can learn the setting schemes of other path switching devices through their function settings and the above examples, and this application will not go into details.

[0052] And, if Figure 8 As shown, a specific structure of a pulse release end (electrode) of an electric pulse ablation device is given. The electrode has a pulse release needle 110, which is used to invade a tumor and release a pulse sequence (electric pulse) to ablate the tumor; the electrode also has an electrode connector 130, one end of the electrode connector 130 is connected to the pulse release needle 110, and the other end is connected to the switching connection point in the pathway switching device, so that after the pathway switching device selects the electrode connector 130 to connect, the electrode can receive the specified pulse sequence and make the end of the pulse release needle 110 emit an electric pulse of the corresponding mode. In addition, according to different actual operation requirements, the electrode may also be configured with a pipeline 140, such as a water pipe or a trachea, so as to facilitate the suction of the accumulated water at the ablation point. In this way, when the pathway switching device is switched to a different electrode connector 130 for connection, the electric pulse mode emitted by the end of the corresponding pulse release needle 110 is different, thereby realizing the flexible and convenient switching of multiple modal functions on a single electric pulse ablation device, and solving the problem of how to conveniently and flexibly use multiple modal functions in a single ablation treatment.

[0053] At the same time, in order to facilitate the doctor's hand-held operation and to protect the connection between the pulse release needle 110 and the electrode connector 130, in the present embodiment, a hand-held part 120 is provided at the connection between the pulse release needle 110 and the electrode connector 130. The hand-held part 120 can specifically be a shell to cover the connection between the pulse release needle 110 and the electrode connector 130 and fix the connecting wire between the pulse release needle 110 and the electrode connector 130.

[0054] Preferably, the type of electrode is stored in the internal storage of the electrode; the data acquisition device is used to obtain the type of electrode and upload it to the control device, specifically, it can be uploaded to the slave controller corresponding to the electrode; the control device is used to determine the pulse sequence provided by the output circuit according to the type of electrode. In order to facilitate the data acquisition device to obtain the electrode type, an internal memory is provided inside the electrode. Of course, the internal memories of multiple electrodes can be integrated in the housing of the handheld part 120, so that the internal memory can be effectively protected and it is convenient for the data acquisition device to collect data.

[0055] Furthermore, in this embodiment, the data acquisition device includes a multi-channel signal input channel, an analog-to-digital converter, a memory and a controller; the multi-channel signal input channel is respectively connected to the multiple electrodes one by one to obtain the electrode signal of each electrode; the analog-to-digital converter is used to convert the acquired electrode signal into a digital signal; the memory is used to store the converted digital signal; the controller is connected to the control device, specifically, it can be connected to the slave controller corresponding to the data acquisition device, so as to control the operation of the data acquisition device under the control of the slave controller, and send the digital signal to the slave controller.

[0056] In this way, by collecting data from the electrodes in real time through the data acquisition device, the control device can confirm in real time whether the electrode currently receiving the pulse sequence is correct and whether the electrode's modality meets the requirements, and can confirm the electrode's working status in real time based on the electrode signal, which is conducive to timely detection and processing when an electrode failure occurs, ensuring the safe use of the electric pulse ablation equipment and reducing the surgical risk of ablation treatment.

[0057] Furthermore, in order to facilitate manual operation and adjust the access of electrodes and the selection of modal functions, in this embodiment, the master controller includes a human-computer interaction interface, and instructions are issued through the human-computer interaction interface so that the slave controller controls the output circuit and the path switching device according to the instructions, or receives digital signals from the data acquisition device.

[0058] The following, combined Fig. 9 and Fig.10 An implementation scheme of a multi-modality-based electric pulse ablation device in a specific embodiment is described.

[0059] like Fig. 9As shown, in this embodiment, the control device specifically includes an IRE main control subsystem (master), an RFA main control subsystem (slave), a UI main control (a slave device of the IRE main control subsystem, used for human-computer interaction), an RFA driver module and an IRE driver module, wherein the RFA driver module is controlled by the RFA main control subsystem, and the IRE driver module is controlled by the IRE main control subsystem; the path switching device is a universal channel switching module, the main function of which is to generate output channels and detect the insertion of electrode channels, and to switch the channels of the connection channels of the electrodes; the data acquisition device is an electrode information acquisition subsystem, the main function of which is to interpret encrypted information and collect information from thermocouples. The UI main control, the RFA main control subsystem and the IRE main control subsystem are connected via a 485 master-slave communication interface.

[0060] In a specific embodiment, when the RFA (radio frequency ablation) mode is used, the IRE main control subsystem sends a command to the RFA main control subsystem, thereby controlling the RFA driver module and the IRE driver module to realize the path switching in the general channel switching module; in addition, the IRE main control subsystem also controls other sub-devices, such as the electrode information acquisition subsystem and the UI main control, to realize the linkage work between the RFA main control subsystem and other sub-devices.

[0061] certainly, Fig. 9 In the example shown, the master controller is only equipped with one slave controller, but in actual applications, the master controller is equipped with more slave controllers to increase the modal functions of different types of electrodes, thereby making the multi-modal electric pulse ablation device more functional. Fig. 9 The method of obtaining the addition of a slave controller in the scheme shown is not repeated in this application.

[0062] Furthermore, in other embodiments, each slave controller may be configured with its own data acquisition device, so as to perform targeted data acquisition on the controlled electrodes; or upload the acquired data to the master controller.

[0063] like Fig.10 As shown, the main control MCU of the control device can be integrated on the FPGA, and the main control MCU can be connected to the high-voltage power supply control (including the high-voltage manager) and the embedded touch screen through serial communication; at the same time, the main control MCU is also connected to the driving circuit (output circuit) and the channel switching circuit (path switching device) through the circuit channel to control the generation of the pulse sequence and the selection of the electrode. At this time, the pulse electric field serves as the main mode, and the function of accessing the electrode serves as an additional mode, thereby realizing multi-modal functional adjustment.

[0064] It should be noted that the present application adopts pulsed electric field as the main mode, mainly considering that among the treatment methods such as pulsed electric field, radio frequency, microwave, ultrasound, and electrocautery, the pulsed electric field has the relatively highest voltage value. Therefore, the functional part of the equipment using pulsed electric field as the main mode has the highest electrical safety requirements. Therefore, the pulsed electric field provides shared resources, which basically naturally meets and far exceeds the safety and performance requirements of other treatment modes; and the sequence of the pulsed electric field is adjustable and has a relatively wide frequency range, thus forming the optimal configuration for resource sharing.

[0065] In this way, the main controller can ensure that only one mode can be output at the same time, and strictly ensure that the system cross-linking does not generate higher risks through active safety control. And the main controller can be highly integrated by using FPGA, making it small in size, full in function and fast in processing speed.

[0066] The multi-modality-based electric pulse ablation device provided in this embodiment can use a combination of multi-mode ablation methods during the treatment of the target area, which can significantly improve the safety, treatment effect, and immune activation of complex diseases; it adopts the optimal resource sharing method and can flexibly combine devices of various modes to avoid equipment complexity and resource waste; users can choose to expand device access or use it independently without increasing the complexity of use.

[0067] It should be noted that the various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other. In addition, the different parts between the various embodiments can also be used in combination with each other, and the present utility model is not limited to this.

[0068] The multi-modal electric pulse ablation device provided in this embodiment includes: an output circuit for providing a controllable pulse sequence; a path switching device configured with multiple electrodes, the path switching device is used to switch each electrode so that the selected electrode receives a specified pulse sequence; a data acquisition device is used to collect electrode signals of multiple electrodes and convert the collected electrode signals into digital signals; a control device includes a master controller and at least one slave controller; the master controller is used to control the operation of all the slave controllers; the slave controller is connected to the output circuit, the path switching device and the data acquisition device to control the output circuit and the path switching device, and receive digital signals from the data acquisition device. By controlling the control of the path switching device by multiple slave controllers through the master controller, flexible switching of multiple electrodes can be achieved. At the same time, the master controller can also be used to control the control of the output circuit by multiple slave controllers to change the pulse sequence provided, so that the connected electrodes can obtain different pulse sequences, and then the switching of multiple modal functions can be flexibly and conveniently realized on a single electric pulse ablation device, solving the problem of how to conveniently and flexibly use multiple modal functions in a single ablation treatment.

[0069] The above description is only a description of the preferred embodiment of the utility model, and is not any limitation on the scope of the utility model. Any changes and modifications made by ordinary technicians in the field of the utility model based on the above disclosure shall fall within the scope of protection of the claims.

Claims

1. A multi-modal electric pulse ablation device, characterized in that: include: an output circuit for providing a controllable pulse train; a path switching device, configured with a plurality of electrodes, the path switching device being used to switch the electrodes so that the selected electrodes receive the designated pulse sequence; A data acquisition device, used for acquiring electrode signals of a plurality of electrodes and converting the acquired electrode signals into digital signals; The control device includes a master controller and at least one slave controller; the master controller is used to control the operation of all the slave controllers; the slave controller is communicatively connected with the output circuit, the path switching device and the data acquisition device to control the output circuit and the path switching device, and receive digital signals from the data acquisition device.

2. The multi-modality based electric pulse ablation device according to claim 1, characterized in that: The output circuit includes two ablation drive circuits; each ablation drive circuit includes an indicating diode, a first switch, a switching control circuit and a second switch which are connected in sequence, and a high-voltage pulse capacitor is connected to the end of the second switch and an end of the first switch close to the diode; The switching control circuits in the two ablation drive circuits are connected in the form of an H-bridge, and the two switching control circuits lead out a first pulse output terminal and a second pulse output terminal respectively. By controlling the on-off state of the two switching control circuits to change the connection loop of the two ablation drive circuits, the pulses output by the first pulse output terminal and the second pulse output terminal are changed.

3. The multi-modality based electric pulse ablation device according to claim 2, characterized in that: The switching control circuit includes two parallel branches, each branch has two switching switches connected in series, and a connecting node is led out between the two switching switches; the connecting node on one branch of one of the switching control circuits is connected to the connecting node on one branch of the other switching control circuit; the connecting node on the other branch leads to the first pulse output end, and the connecting node on the other branch of the other switching control circuit leads to the second pulse output end.

4. The multi-modality based electric pulse ablation device according to claim 2, characterized in that: The switching control circuit also includes a voltage balancing circuit, which includes two transistor units connected in series; each transistor unit includes a transistor, a diode, a first resistor, a second resistor and a capacitor; the source of the transistor is respectively connected to the positive electrode of the diode, one end of the first resistor and one end of the second resistor, the cathode of the diode is respectively connected to the other end of the first resistor and the positive electrode of the capacitor, and the cathode of the capacitor is respectively connected to the other end of the second resistor and the drain of the transistor; the drain of the transistor of one transistor unit is connected to the source of the transistor of the other transistor unit.

5. The multi-modality based electric pulse ablation device according to claim 2, characterized in that: The output circuit also includes a high-voltage power supply; the high-voltage power supply is used to power the ablation drive circuit; the high-voltage power supply includes an AC input terminal and a high-voltage output terminal, the live wire of the AC input terminal is connected to the live wire of the high-voltage output terminal, and the neutral wire of the AC input terminal is connected to the neutral wire of the high-voltage output terminal; between the live wire and the neutral wire, a power supply capacitor, a power supply resistor and a power supply transformer are connected in parallel.

6. The multi-modality based electric pulse ablation device according to claim 5, characterized in that: A safety switch and a fuse are provided on the live wire and / or the neutral wire.

7. The multi-modality based electric pulse ablation device according to claim 5, characterized in that: The output circuit further includes a high voltage manager; the high voltage manager is used to control the supply of power from the high voltage power supply to the ablation driving circuit.

8. The multi-modality based electric pulse ablation device according to claim 2, characterized in that: The output circuit also includes a current protection circuit; the current protection circuit is used to perform overload protection on the output circuit when the current of the output pulse sequence exceeds a threshold value.

9. The multi-modality based electric pulse ablation device according to claim 1, characterized in that: The path switching device has a plurality of switching connection points, and each electrode is respectively connected to one of the switching connection points.

10. The multi-modality based electric pulse ablation device according to claim 1, characterized in that: The data acquisition device includes a multi-channel signal input channel, an analog-to-digital converter, a memory and a controller; the multi-channel signal input channel is respectively connected to the plurality of electrodes in communication with each other to obtain the electrode signal of each electrode; The analog-to-digital converter is used to convert the acquired electrode signal into a digital signal; the memory is used to store the converted digital signal; the controller is communicatively connected to the slave controller, and is used to control the operation of the data acquisition device under the control of the slave controller, and send the digital signal to the slave controller.

11. The multi-modality based electric pulse ablation device according to claim 1, characterized in that: The master controller includes a human-machine interaction interface, and commands are issued through the human-machine interaction interface so that the slave controller controls the output circuit and the path switching device according to the commands, or receives digital signals from the data acquisition device.

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