Small-dose automatic filling equipment based on PLC program

Abstract

According to the small-dose automatic filling equipment based on the PLC program, automatic batch filling is accurately controlled through the PLC control system, meanwhile, accurate quantification and displacement of liquid are achieved through cooperation of the rotary valve, the injector and the injection needle, the problems that manual filling is low in accuracy and long in consumed time are well solved, and the production efficiency is improved. According to the automatic filling device, liquid is filled into ampoule bottles or glass sample bottles or plastic sample bottles or small sample injection bottles or other filling containers in batches from volumetric flasks in a laboratory, operation is convenient, time and labor are saved, the filling efficiency is greatly improved, meanwhile, automatic filling is achieved through a PLC program, the editable degree of the whole filling device is greatly improved, and the production efficiency is improved. And parameters can be finely adjusted and corrected according to actual conditions, so that the accuracy of transmission between parts is accurately improved.

Description

Technical Field

[0001] The utility model relates to the technical field of small-dose liquid automatic filling equipment, in particular to a small-dose liquid automatic filling equipment based on a PLC program. Background Art

[0002] Programmable Logic Controller (PLC) is a digital computing controller with a microprocessor for automatic control. It can load control instructions into memory at any time for storage and execution. The programmable controller is composed of CPU, instruction and data memory, input / output interface, power supply, digital analog conversion and other functional units. The early programmable logic controller only had the function of logic control, so it was named programmable logic controller. Later, with continuous development, these computer modules with simple functions at the beginning have various functions including logic control, timing control, analog control, multi-machine communication, etc.; PLC is widely used in the filling field, but during filling, the uncertainty of filling equipment often causes PLC program setting problems and filling errors. In addition, during the filling process, multiple tests cannot be performed, the PLC program cannot be changed autonomously, and the PLC program cannot be adjusted autonomously according to the filling equipment, filling materials, etc.

[0003] The filling of small or trace amounts of liquids is indispensable in the preparation of standard solutions, biology, chemistry, medicine, pharmaceutical and other experimental operations. Currently, laboratories generally measure and fill them manually. When encountering filling operations for large-scale experiments, manual operations are cumbersome and time-consuming. The filling capacity of the automatic filling equipment on the market can reach tens of thousands of milliliters. It is mainly used for filling large doses of liquids in the food industry, beverage industry, daily chemical industry, etc. The equipment occupies a large area and the filling liquid dosage is large. It is not suitable for small-dose liquid batch filling experiments in laboratory operations.

[0004] In terms of technology, the packaging of standard solutions requires more sophisticated control and operation methods, and large-scale filling equipment is usually designed for large-scale production. Its technology and structure cannot meet the laboratory's small-dose operation requirements; in terms of cost, large-scale filling equipment is relatively expensive, and the purchase, maintenance and operating costs are not suitable for low-demand scenarios such as small-dose use in laboratories, which will result in waste of resources; in terms of efficiency, although large-scale equipment is efficient in large-scale production, for small-dose filling, its startup, adjustment and operation processes may be cumbersome, resulting in low efficiency; in terms of precision, the precision of large-scale equipment is difficult to meet the high-precision requirements of small-dose filling in laboratories, and small-dose filling requires more precise control and measurement.

[0005] The equipment currently available on the market for automatic liquid filling, although equipped with automatic pipetting functions, is not specially designed for automatic pipetting and filling purposes, but is instead combined with other functions: on the one hand, the needs of other functions may conflict with the automatic pipetting function, such as the need to frequently switch modes or adjust parameters during operation, resulting in inconvenient operation or reduced efficiency; on the other hand, the design of the equipment may focus more on other functions, while the automatic pipetting function may only serve as an additional module. Therefore, when dealing with specific pipetting and filling tasks, it may not be able to fully meet the requirements, such as limited adaptability to pipetting accuracy, filling accuracy, speed, capacity range, etc.; at the same time, the connection with other functions may increase the complexity of the equipment, making the operation and maintenance of the equipment more complex, thereby requiring a higher level of technology and more training to correctly use and maintain the equipment; on the other hand, in order to achieve the integration of multiple functions, the cost of the equipment is significantly increased.

[0006] For example, the BP100 automatic rapid liquid dispenser (Rui Ke Group (Xiamen) Co., Ltd.) and the intelligent liquid extraction system (Beijing Labtech Instrument Co., Ltd.) involve automatic liquid dispensing, but they are not aimed at the automatic filling of small doses of liquids. Instead, they are connected with other functions, making them unsuitable for special automatic liquid filling purposes. At the same time, the equipment is costly, complex in structure, and difficult to operate, and is not suitable for daily automatic filling of small doses of liquids in laboratories.

[0007] Therefore, it is urgent to find an automatic filling equipment suitable for laboratory small-dose liquid filling, which is specially designed for laboratory liquid automatic filling, and has low equipment cost, simple structure, low operation difficulty, and through the PLC control system, it can replace manual filling operation and realize small-dose liquid automatic filling, thereby improving filling accuracy and production efficiency and reducing labor intensity. Utility Model Content

[0008] In order to solve the problems existing in the prior art, the utility model provides a small-dose automatic filling equipment based on a PLC program. Batch filling is accurately controlled by a set of PLC programs. For the first time, a set of equipment specially suitable for automatic filling of small-volume liquids is designed. The equipment has low cost, simple structure, and low operation difficulty. It well solves the problems of low accuracy, long time consumption, high labor intensity, and low efficiency of manual filling, and realizes the batch filling of liquids from volumetric flasks into ampoules, glass sample bottles, plastic sample bottles, injection vials, or other filling containers in the laboratory. The operation is convenient, time-saving and labor-saving, and the filling efficiency is greatly improved.

[0009] In order to achieve the above purpose, the utility model adopts the following scheme:

[0010] On the one hand, the utility model provides a small-dose automatic filling device, including a syringe system, wherein the syringe system includes a valve, a syringe, and a syringe pump, wherein the valve and the syringe are combined into an integrated structure for completing automatic absorption and discharge of liquid;

[0011] The valve is used for the circulation of liquid;

[0012] Syringes are used for automatic aspiration and discharge of liquids;

[0013] The syringe pump is used to provide power for the automatic aspiration and expulsion of the syringe.

[0014] Furthermore, the syringe opens upward, and a valve is connected to the opening.

[0015] Although the small-dose automatic filling equipment designed by the utility model takes "automatic quantitative filling of 2mL ampoules" as an example, it can be understood that when quantitative automatic filling of ampoules or containers of other volumes is required, such as ampoules of 1-100mL or glass sample bottles or plastic sample bottles or other filling containers, it can be further optimized on the basis of the structure of the utility model, such as optimizing the filling capacity of the syringe, the filling capacity of the injection needle, the length of the injection needle, the depth of the injection needle, the angle of the rotary valve, the number of holes in the tray, the size of each aperture, the volume of the volumetric flask, etc., which can be optimized and improved according to the size of the filling container, and is not limited to "automatic filling of 2mL ampoules".

[0016] Similarly, it should be understood that terms such as "round", "square", etc. used to describe the appearance of an ampoule or other structure are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific shape or appearance, and therefore cannot be understood as a limitation on the present invention.

[0017] Furthermore, the valve is provided with a first one-way valve and a second one-way valve; when the first one-way valve is turned on, the second one-way valve is closed; or when the second one-way valve is turned on, the first one-way valve is closed; the first one-way valve and the second one-way valve are used to control the filling accuracy and prevent liquid backflow.

[0018] In some embodiments, the valve is a rotary valve, and the angle deflection of the rotary valve must be strictly controlled. If an angle deviation occurs, it will cause poor liquid flow and affect the precision and accuracy of packaging.

[0019] In some embodiments, in order to successfully realize the automatic filling of small-dose (2mL) ampoules in the laboratory, an automatic filling device suitable for small-dose liquid filling in the laboratory is designed. In the preliminary design, the automatic filling module includes a syringe and a syringe pump. The syringe is connected to the syringe pump through a clamping structure. A valve is set at the bottom of the syringe. In the filling mode, the syringe pump drives the syringe to move downward, and the liquid to be filled enters the syringe barrel through the liquid inlet pipeline, and the valve is opened for subpackaging. However, under this design, the sealing degree of the valve is significantly reduced after long-term operation, resulting in leakage, which significantly reduces the filling accuracy.

[0020] Therefore, in order to solve the above problems, in the subsequent structural design, the equipment structure is further optimized, a rotary valve and an injection needle structure are added to the automatic filling module, and the syringe structure is improved. The upper end of the syringe is connected to a rotary valve, and the syringe includes a syringe barrel, a piston, a push rod, and a push rod connector. The syringe is connected to the elastic structure inside the injection pump through the push rod connector at the bottom of the push rod. The first one-way valve and the second one-way valve are arranged on the rotary valve, and one end of the liquid inlet pipeline is connected to the first one-way valve, and the other end is connected to the container of the liquid to be filled; one end of the liquid discharge pipeline is connected to the second one-way valve, and the other end is connected to the injection needle. In the filling mode, when the first one-way valve is turned on, the second one-way valve is closed; or when the second one-way valve is turned on, the first one-way valve is closed (as described in the optimal structure in Example 1). After the structure is optimized, when the set volume of liquid to be filled enters the first one-way valve through the liquid inlet pipeline (at this time, the second one-way valve must be kept closed) and then enters the syringe, the syringe performs secondary quantification on the liquid to be filled. Through the cooperation of the syringe, the rotary valve, the first one-way valve and the second one-way valve, secondary quantification of the liquid to be filled can be achieved, which significantly improves the filling accuracy, thereby realizing accurate quantification and automatic filling of the liquid; at the same time, leakage can be avoided.

[0021] Furthermore, the syringe system also includes a liquid inlet pipeline and a liquid discharge pipeline, the first one-way valve is connected to one end of the liquid inlet pipeline, and the second one-way valve is connected to one end of the liquid discharge pipeline.

[0022] Furthermore, the syringe includes a syringe barrel, a piston, a push rod, and a push rod connector. The syringe pump drives the push rod to reciprocate, driving the liquid to enter the syringe barrel through the first one-way valve.

[0023] In some embodiments of the present invention, the syringe can be selected in different specifications and models according to different filling volumes.

[0024] Furthermore, the injection pump includes an elastic structure, and the elastic structure is combined with the push rod into an integrated structure through a push rod connector. The injection pump drives the push rod to perform reciprocating motion through the elastic structure.

[0025] In some embodiments, through the cooperation of a syringe, a rotary valve, a syringe pump, a first one-way valve and a second one-way valve, secondary quantification of the liquid to be filled can be achieved, which significantly improves the filling accuracy and thus achieves accurate quantification of the liquid.

[0026] Furthermore, the small-dose automatic filling equipment also includes an injection needle system, which includes an injection needle, an injection needle fixing plate, a slider, a slider adapter plate, and a slide rail. The injection needle fixing plate, the slider, and the slider adapter plate are combined into an integrated structure.

[0027] Furthermore, the injection needle opens upward, and the opening is connected to one end of a liquid discharge pipeline for the circulation of liquid.

[0028] Furthermore, the injection needle is connected to the slide block via an injection needle fixing plate, and the slide block drives the injection needle to reciprocate on the slide rail to achieve automatic filling of the liquid.

[0029] In some embodiments, the length of the injection needle is 55mm-65mm, to avoid the injection needle being too short and causing the liquid to splash onto the bottle wall, and to avoid the injection needle being too long and touching the liquid surface, causing pollution or loss. The length of the injection needle can be adjusted according to the volume of the filling container. In the present utility model, the length of the injection needle is limited according to the size of the 2mL ampoule bottle. However, it is understandable that when it is applicable to filling containers of other sizes, the length of the injection needle can be adjusted accordingly, and is not limited to the length range in the embodiments of the present utility model.

[0030] Furthermore, the small-dose automatic filling equipment also includes a filling system, which includes a positioning plate and a tray. The positioning plate and the tray are combined into an integrated structure for completing automatic batch filling of liquids.

[0031] Furthermore, the positioning plate and the tray are a detachable integrated structure.

[0032] The beneficial effects of the utility model are:

[0033] 1. The small-dose automatic filling equipment based on PLC program provided by the utility model has a simple structure, small footprint, strong mobility, and is used in conjunction with the 2mL ampoule bottle of Tianjin Alta Technology Co., Ltd. Laboratory. The specifications, size, caliber and shape of the ampoule bottle are consistent with the tray in the equipment. Through the cooperation of the rotary valve, syringe, and injection needle, the rotary valve angle, injection needle depth, tray calibration angle, volume calibration and other conditions are precisely controlled at the same time, so that the precise quantification and displacement of the liquid can be achieved; and when it is necessary to perform quantitative automatic filling of ampoules or containers of other volumes, such as 1-100mL ampoules or glass sample bottles or plastic sample bottles or other filling containers, the size specifications of each structure in the utility model can be adjusted accordingly;

[0034] 2. The small-dose automatic filling equipment based on PLC program provided by the utility model is simple and convenient to operate, can replace manual filling operation, and realizes the automation of small-dose filling. Through practical application, it is found that the filling accuracy of the utility model increases the filling accuracy of the traditional filling production line from ±2% to nearly ±0.1%, which significantly improves the accuracy of filling.

[0035] 3. The utility model provides a method for realizing automatic filling of small doses. By using an automatic filling device for small doses of liquid, the method can realize batch filling of liquid from volumetric flasks into ampoules, glass sample bottles, plastic sample bottles, injection vials or other filling containers in the laboratory. The method is convenient to operate, saves time and effort, and greatly improves the filling efficiency.

[0036] 4. The utility model adopts PLC program to realize automatic filling, which greatly improves the editability of the entire filling equipment. The parameters can be fine-tuned according to actual conditions to accurately improve the accuracy of transmission between components. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 This is a three-dimensional structural diagram of the small-dose automatic filling equipment based on the PLC program of the utility model.

[0038] Figure 2 This is the left view of the small-dose automatic filling equipment based on the PLC program hidden behind the machine cover.

[0039] Figure 3 This is the three-dimensional structural diagram of the small-dose automatic filling equipment based on the PLC program hidden behind the machine cover.

[0040] Figure 4 This is a three-dimensional structural diagram of the rotary valve + syringe + injection pump.

[0041] Figure 5 This is a three-dimensional structural diagram of the injection needle (front view).

[0042] Figure 6 This is the three-dimensional structure diagram of the injection needle (right view).

[0043] Figure 7 This is the three-dimensional structure diagram of the injection needle (left view).

[0044] Figure 8 The three-dimensional structure diagram of the ampoule bottle used in conjunction with the utility model. DETAILED DESCRIPTION

[0045] The present invention is further described in detail below in conjunction with the embodiments. It should be pointed out that the embodiments described below are intended to facilitate the understanding of the present invention and do not have any limiting effect on the present invention.

[0046] Unless otherwise specified, the experimental methods used in the following examples are conventional methods.

[0047] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0048] The utility model is a small-dose automatic filling equipment based on PLC program, which is aimed at the small-dose filling of 2mL ampoule bottles (purchased from Schott Pharmaceutical Packaging (Zhejiang) Co., Ltd., specification 2ml, height*bottom diameter / upper diameter: 75*11.5mm / 5mm, item number 1757899) in the internal laboratory of Tianjin Alta Technology Co., Ltd. According to its size requirements, it is customized by Shaanxi Manchen Mechanical and Electrical Equipment Co., Ltd. as a matching automatic filling equipment, and its size corresponds to the size specification of the 2mL ampoule bottles in the laboratory of Tianjin Alta Technology Co., Ltd. Therefore, it is also called ampoule automatic filling equipment, ampoule filling machine, standard solution automatic filling machine or standard solution automatic dispenser.

[0049] To facilitate a better understanding of the technical solution of the utility model, in the utility model, "quantitative automatic filling of 2mL ampoules" is taken as an example, but it can be understood that when quantitative automatic filling of ampoules or containers of other volumes is required, such as ampoules of 1-100mL or glass sample bottles or plastic sample bottles or injection vials or other filling containers, they can be further optimized on the basis of the structure of the utility model, such as optimizing the filling capacity of the syringe, the filling capacity of the injection needle, the length of the injection needle, the depth of the injection needle, the angle of the rotary valve, the number of holes in the tray, the size of each aperture, the volume of the volumetric flask, etc., which can be optimized and improved according to the size of the filling container, and are not limited to "automatic filling of 2mL ampoules".

[0050] Similarly, it should be understood that terms such as "round", "square", etc. used to describe the appearance of an ampoule or other structure are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific shape or appearance, and therefore cannot be understood as a limitation on the present invention.

[0051] Example 1 The utility model provides a small dose automatic filling device based on PLC program

[0052] 1. Basic structure of small-dose automatic filling equipment based on PLC program

[0053] This embodiment provides a small-dose automatic filling device based on a PLC program. Figures 1 to 8 shown.

[0054] from Figures 1 to 8It can be seen that the small-dose automatic filling equipment based on the PLC program is divided into a parameter setting module, a pipeline cleaning module, and an automatic filling module. The automatic filling module includes a syringe system and an injection needle system. The syringe system includes a rotary valve 1, a syringe 2, an injection pump 3, a liquid inlet pipeline 5, and a liquid discharge pipeline 6. The rotary valve 1 is provided with a first one-way valve 7 (to control liquid inlet) and a second one-way valve 8 (to control liquid discharge). The first one-way valve 7 and the second one-way valve 8 have the same angle with the syringe 2, both of which are 120 degrees to 180 degrees. The first one-way valve 7 is connected to the liquid inlet pipeline 5, and the second one-way valve 8 is connected to the liquid discharge pipeline 6. The rotary valve 1 is fixed on the fixed back plate 9; the lower part of the rotary valve 1 is connected to the upward opening of the syringe 2, and the syringe 2 must be kept perpendicular to the horizontal plane, and the angle of the rotary valve cannot be deflected (if deflection occurs later, the "rotary valve angle adjustment" must be carried out in time). The syringe 2 comprises a syringe barrel 10, a piston and a push rod 12. The piston is located inside the syringe barrel 10. The push rod 12 is connected to the piston and is used to push the piston to move. A push rod connector 11 is provided at the bottom of the push rod 12, which is connected to the elastic structure 13 inside the injection pump 3. The injection pump 3 is fixed on the fixed back plate 9 through the injection pump fixing seat 14. The injection pump 3 has a motor 15 inside, and the motor 15 drives the elastic structure 13 to reciprocate: in the initial state, the piston is located at the top position of the syringe 10. After the filling volume is set, the motor 15 drives the elastic structure 13 to move downward for a certain distance, thereby pulling the piston to the corresponding position of the corresponding volume, so that the liquid to be filled enters the liquid inlet pipeline 5 from the container (volume flask 16), and enters the syringe 10 after passing through the first one-way valve 7 (at this time, the first one-way valve 7 is turned on and the second one-way valve 8 is closed); then the motor 15 drives the elastic structure 13 back to the initial position, thereby pushing the piston back to the initial position, and then pushing the liquid through the second one-way valve 8 into the discharge pipeline 6. The discharge pipeline 6 is connected to the injection needle 4 in the injection needle system, and then the liquid enters the injection needle 4 to start filling. Among them, the edge of the piston is in sealing contact with the syringe 10 to avoid leakage (specifically, Figure 4 shown).

[0055] The injection needle system includes an injection needle 4, an injection needle fixing plate 17, an inductive proximity switch 18 (OMRON, TL-Q5MD2), a two-phase stepping screw motor 19, an electric push rod fixing seat 20, a slider adapter plate 21, a slider 22 and a fixing plate 23. The two-phase stepping screw motor 19 is fixed to one side of the fixed back plate 9 through the electric push rod fixing seat 20, and the inductive proximity switch 18 is fixed to one side of the two-phase stepping screw motor 19; the slider 22 is concave in the middle and is engaged with the fixing plate 23, and can slide up and down along the fixing plate 23, the fixing plate 23 is fixed to one side of the fixed back plate 9, the slider 22 is fixedly connected to the slider adapter plate 21, and the slider adapter plate 21 is fixed to the two-phase stepping screw motor 19, and can move up and down along the motor rod 24 of the two-phase stepping screw motor 19. The injection needle 4 is fixed to the injection needle fixing plate 17, and the injection needle fixing plate 17 is fixedly connected to the slider adapter plate 21 through a nut. When in the filling mode, the injection needle 4 receives the liquid in the discharge pipe 6, and under the drive of the two-phase stepping screw motor 19, it reciprocates up and down along the motor rod 24 with the slider 22 at the set "injection needle depth", thereby realizing automatic filling of the liquid (specifically, Figure 5 to Figure 7 shown).

[0056] The automatic filling module also includes a filling system, which includes a positioning plate 27 and a tray 28. The positioning plate 27 and the tray 28 are combined into a detachable integrated structure, which is an ampoule bottle 29 placement area for completing batch automatic filling of liquids.

[0057] In the injection needle system, the automatic filling adopts the principle of the xyz-axis mechanical arm mode, and is powered by a two-phase stepping screw motor 19, and with the cooperation of the slider 22, the slider adapter plate 21, the fixed plate 23 and other structures, drives the injection needle 4 to perform precise and stable reciprocating motion along the z-axis. At the same time, the positioning plate 27 drives the tray 28 to perform continuous and uniform rotational motion. Through the precise motion control capability of the xyz-axis mechanical arm, combined with the rotation of the tray 28, the injection needle 4 and the ampoule 29 can be accurately positioned. Under the precise drive of the tray 28, when the ampoule 29 rotates to a specific position, the vertical reciprocating motion of the injection needle along the z-axis enables it to be accurately inserted into the ampoule 29, thereby completing the automatic filling operation. In the utility model, combined with the above-mentioned mechanical structure and the principle of motion control, the efficiency, accuracy and reliability of the filling process are ensured to meet the strict requirements in the production process.

[0058] The automatic filling module also includes a bottom support plate 25, on which a volumetric bottle placement table 26 is provided; the volumetric bottle 16 is fixed by a spring sheet clamp tube buckle 30, and a spring sheet clamp tube buckle fixing rod 31 passes through the fixed back plate 9 and is connected to the NES-100 switch power supply 32. The machine cover 33 of the small-dose automatic filling device is connected to the bottom support plate 25, and the machine cover 33 includes an editable logic controller 34 (PLC, Omron, NX1P2-9024DT), a two-phase stepping motor 35, a motor driver 36, a NES-100 switch power supply 32, a syringe pump 3, and a two-phase stepping screw motor 19.

[0059] The parameter setting module includes an operation panel 37, an emergency stop button 38 and a start button 39. The structure of the pipeline cleaning module is basically the same as that included in the automatic filling module, and the only difference is in the operation process.

[0060] 2. Working principle of small-dose automatic filling equipment based on PLC program

[0061] When the automatic filling device of the utility model is working, the filling volume is set on the operation interface, and the internal motor 15 of the injection pump 3 drives the elastic structure 13 to reciprocate, thereby driving the syringe 2, so that the syringe 2 absorbs the liquid of the volume specified by the filling volume. At this time, the first one-way valve 7 is opened, and the liquid enters the first one-way valve 7 through the liquid inlet pipeline 5 and enters the syringe 2; at this time, the first one-way valve 7 is closed, and the second one-way valve 8 is opened, and the syringe 2 pushes the liquid through the second one-way valve 8 and the discharge pipeline 6 into the injection needle 4, and the two-phase stepping screw motor 19 drives the injection needle 4 to reciprocate up and down along the motor rod 24 with the slider 22 at the set "injection needle depth" to perform automatic filling. The positioning plate 27 can rotate counterclockwise. When filling starts, the positioning plate 27 drives the tray 28 to rotate counterclockwise, and 35 ampoules 29 are automatically filled in turn. The rotation speed is adjusted according to the filling time and interval of each ampoule 29. When one ampoule 29 is filled, the positioning plate 27 rotates to the position of the next ampoule 29 for filling again.

[0062] 3. Operation process of small-dose automatic filling equipment based on PLC program

[0063] The specific operation process of this utility model is as follows:

[0064] 1. Parameter setting: The operation panel 37 includes an operation interface, an origin interface, a parameter interface and a monitoring interface. When setting for the first time, first set the origin interface, set the tray 28 speed to 300, the rotary valve 1 speed to 500, the injection pump 3 speed to 800, and the injection needle 4 speed to 500. After the initial setting, the parameters can be used in the future without modification. Then enter the operation interface, set the filling volume to 0-2.5ml, generally 0.5ml or 1.2ml, according to the actual situation; set the filling quantity to 35 bottles (the maximum number of filled ampoules 29 is 35, of which the 36 holes of the tray 28 include 1 hole for origin calibration and 35 holes for filling ampoules 29); set the filling count, cleaning times and cleaning count according to actual needs; set the cleaning volume to 2.0mL, and the maximum range of the syringe 2 to 2.5mL (in this embodiment, the syringe range is limited according to the specifications of the 2mL ampoule, but it can be understood that when it is applicable to filling containers of other sizes, the syringe range and specifications can be adjusted accordingly, not just limited to the maximum range in this embodiment), and control the position of the syringe 2 in the cleaning mode by setting the cleaning volume, so as to clean the rotary valve 1, the syringe 2, the injection needle 4 and the entire pipeline. In the operation interface, when the pointer is upward, it is in the filling mode, and when the pointer points downward, it is in the cleaning mode.

[0065] 2. Cleaning mode: After setting the parameters, adjust the mode to "cleaning mode" in the operation interface, immerse the inlet pipe 5 in the cleaning liquid, and place a cleaning waste liquid receiving container at the outlet of the discharge pipe 6; click the "Start / Stop Button" on the operation interface to start cleaning the pipe. After the cleaning is completed, long press the "Count Reset" button to remove the cleaning liquid from the inlet pipe 5, and then click the "Start / Stop Button" to drain the liquid in the pipe (perform the cleaning operation twice); take out a part of the filling liquid and put it into another container (volume flask 16), immerse the inlet pipe 5 in the container (volume flask 16) filled with the filling liquid, and place the container filled with the filling liquid in the container placement area to be filled on one side of the equipment (volume flask placement table 26), click the "Start / Stop Button" on the operation interface to start cleaning the pipe. After the cleaning is completed, remove the inlet pipe 5 from the container and remove the cleaning waste liquid receiving container.

[0066] 3. Filling mode: After cleaning, adjust the mode to "filling mode" in the operation interface, immerse the liquid inlet pipeline 5 in the container (volume flask 16) containing the liquid to be filled, and place the container of liquid to be filled in the container placement area (volume flask placement table 26) on one side of the equipment; remove the tray 28 from the equipment positioning plate 27 (in this embodiment, the tray 28 contains 36 tray origin holes, but it can be understood that when it is suitable for filling containers of other sizes, the number of holes and the aperture of the tray 28 can be adjusted accordingly, and are not limited to the number of holes and apertures of the tray in this embodiment) and click the "tray removal confirmation" button on the operation interface, place the ampoule bottle 29 for filling on the tray 28, and after placing the ampoule bottle 29, install the tray 28 on the positioning plate 27 of the ampoule bottle 29 filling machine, and then click "tray placement confirmation", click the "start and stop button" to start automatic filling of liquid, and complete the filling according to the set filling quantity.

[0067] 4. The role of different structures in small-dose automatic filling equipment based on PLC program

[0068] The small-dose automatic filling equipment based on PLC program provided by the utility model has the following functions in different structures:

[0069] (1) Rotary valve 1: controls liquid inlet and outlet. The rotary valve 1 is provided with a first one-way valve 7, which is connected to the liquid inlet pipeline 5 to control liquid inlet; the rotary valve 1 is provided with a second one-way valve 8, which is connected to the liquid outlet pipeline 6 to control liquid outlet; when the first one-way valve 7 is turned on, the second one-way valve 8 is closed; or when the second one-way valve 8 is turned on, the first one-way valve 7 is closed. The angle deflection of the rotary valve 1 must be strictly controlled. If an angle deviation occurs, it will cause poor liquid flow and affect the precision and accuracy of the packaging.

[0070] (2) Syringe 2: connected to the lower part of the rotary valve 1, perpendicular to the horizontal plane. In the cleaning mode, the cleaning liquid is sucked according to the set cleaning volume and discharged through the second one-way valve 8; in the filling mode, the liquid to be filled is sucked according to the set filling volume and discharged through the second one-way valve 8. When the set volume of the liquid to be filled enters the first one-way valve 7 through the liquid inlet pipeline 5 (at this time, the second one-way valve 8 must be kept closed) and then enters the syringe 2, the syringe 2 performs secondary quantification of the liquid to be filled. Through the cooperation of the syringe 2, the rotary valve 1, the injection pump 3, the first one-way valve 7 and the second one-way valve 8, the secondary quantification of the liquid to be filled can be achieved, which significantly improves the filling accuracy, thereby achieving accurate quantification of the liquid.

[0071] The syringe 10 includes a syringe barrel 10, a piston and a push rod 12. A closed space is formed between the syringe barrel 10 and the piston to prevent liquid leakage and can be used for the absorption and discharge of liquid. A push rod connector 11 is provided at the bottom of the push rod 12, which is connected to the elastic structure 13 inside the syringe pump 3. The motor 15 inside the syringe pump 3 drives the syringe 2 to reciprocate with the elastic structure 13, thereby realizing automatic filling of liquid.

[0072] (3) Injection pump 3: provides power for the movement of the first one-way valve 7, the second one-way valve 8 and the syringe 2.

[0073] (4) Syringe pump fixing seat 14: fixes the syringe pump 3.

[0074] (5) Injection needle 4 (probe): connected to the second one-way valve 8 through the discharge pipe 6. When in the filling mode, the injection needle 4 receives the liquid in the discharge pipe 6. Driven by the two-phase stepping screw motor 19, the injection needle 4 reciprocates up and down along the motor rod 24 at the set "injection needle depth" together with the slider 22, thereby realizing automatic filling of the liquid; the length of the injection needle 4 is 55mm-65mm, and in this embodiment, it is specifically 60mm, to avoid the injection needle 4 being too short to cause the liquid to splash onto the bottle wall, and to avoid the injection needle 4 being too long to touch the liquid surface, causing pollution or loss.

[0075] (6) Two-phase stepping screw motor 19: provides power for the movement of the injection needle 4, and drives the injection needle 4 to reciprocate on the motor rod 24 together with the slider 22 in the filling mode.

[0076] (7) Liquid inlet pipeline 5: ensures successful absorption of liquid. In the cleaning mode, one end is immersed in the cleaning liquid, and the other end is tightly connected to the first one-way valve 7; in the filling mode, one end is immersed in the container containing the liquid to be filled, and the other end is tightly connected to the first one-way valve 7.

[0077] (8) Liquid discharge line 6: ensures successful discharge of liquid. One end is tightly connected to the second one-way valve 8, and the other end is tightly connected to the upper part of the injection needle 4.

[0078] (9) Fixing back plate 9: fixing NES-100 switching power supply 32, injection pump 3, two-phase stepping screw motor 19, and fixing plate 23.

[0079] (10) Elastic structure 13: located inside the injection pump 3, connected to the push rod connector 11 at the bottom of the push rod 12, and driven by the motor 15 to drive the push rod 12 to reciprocate, thereby achieving liquid suction and discharge.

[0080] (11) Motor 15: located inside the injection pump 3, driving the elastic structure 13 to perform reciprocating motion.

[0081] (12) Injection needle fixing plate 17: fixes the injection needle 4.

[0082] (13) Inductive proximity switch 18: A position switch that can be operated without direct contact with the structure. In the filling mode, it sends instructions to the two-phase stepper screw motor 19.

[0083] (14) Two-phase stepping screw motor 19: drives the injection needle 4 to reciprocate along with the slider 22.

[0084] (15) Electric push rod fixing seat 20: fixes the two-phase stepping screw motor 19.

[0085] (16) Slider adapter plate 21: The slider 22 is fixedly connected to the slider adapter plate 21, and the injection needle fixing plate 17 is fixedly connected to the slider adapter plate 21 via a nut, driving the injection needle 4 to reciprocate along with the slider 22.

[0086] (17) Slider 22: Driven by the two-phase stepping screw motor 19, it drives the injection needle 4 to perform reciprocating motion to achieve automatic filling of liquid.

[0087] (18) Volumetric bottle placement table 26: In the cleaning mode, a container filled with cleaning liquid is placed thereon; in the filling mode, a container (volume flask 16) filled with liquid to be filled is placed thereon.

[0088] (19) Positioning plate 27: fixes the position of the tray 28 to ensure the subsequent successful dispensing of liquid, and can be rotated counterclockwise.

[0089] (20) Tray 28: It is an ampoule bottle 29 placement area, including 35 ampoule bottle 29 placement positions and 1 origin calibration position.

[0090] (21) NES-100 switching power supply 32: A commonly used power supply module that provides the required power for the equipment.

[0091] (22) Programmable logic controller 34 (PLC): realizes automatic control of small-dose automatic filling equipment according to the written program and input instructions.

[0092] (23) Two-phase stepper motor 35: provides power for automation equipment and drives the actuator to complete specific actions.

[0093] (24) Motor driver 36: drives the motor.

[0094] (25) Emergency stop button 38: During the filling process, if there is an abnormal phenomenon such as the injection needle 4 hitting the wall or contacting the liquid surface, the machine can be stopped urgently.

[0095] (26) Power button 39: controls normal power on.

[0096] (27) Operation panel 37: Set different parameters, such as "filling volume" (min-max: 0-2.5mL), "filling quantity" (min-max: 0-35), "cleaning volume" (min-max: 0-2.5mL), "cleaning times" (min-max: 0-35), etc. After setting, long press the "count reset" button to reset the "filling count" and "cleaning count" parameters.

[0097] 5. Operation requirements of small-dose automatic filling equipment based on PLC program

[0098] In the small-dose automatic filling device based on the PLC program, the following points should be noted to achieve precise displacement of the filling liquid in the utility model by strictly controlling the angle of the rotary valve 1, the volume calibration of the syringe 2, the tray calibration, and the depth adjustment of the syringe 2:

[0099] (1) In the parameter interface, other parameters have been set and do not need to be changed. After a long period of use, it is necessary to adjust the angle of the rotary valve 1, perform volume calibration of the syringe 2, tray calibration, and depth adjustment of the syringe 2: ① Since the syringe 2 may be worn after the equipment has been used for too long, or other syringes 2 need to be replaced, it is necessary to perform volume calibration, draw liquid according to the set volume, observe whether the discharged liquid is the corresponding volume, and then make corresponding adjustments; ② Since the injection needle 4 may be deformed due to touching the bottle wall when moving up and down, if it is deformed by hitting the wall each time it is used, it is necessary to recalibrate the injection needle 4, fix its angle, and observe whether the hitting the wall phenomenon still exists when it is run again; on the other hand, the injection needle 4 will move downward during packaging, and normally it should be lowered to the black spot on the neck of the 2mL ampoule bottle 29 provided in the laboratory (specifically as shown in the figure below). Figure 8 As shown, the vertical distance between the black spot position of the ampoule bottle 29 and the bottle mouth is 35-40mm, and in this embodiment, it is specifically 37mm). If the position of the injection needle 4 is too shallow when it moves downward, the injection needle 4 may hit the corner of the bottle; if the position of the injection needle 4 is too deep when it moves downward, it may be stained with the solution to cause cross contamination. Therefore, it is necessary to observe whether the movement height of the injection needle 4 meets the requirements during operation. Generally, the depth of the injection needle 4 is adjusted to about 55-65mm, and in this embodiment, it is specifically 60mm, which is determined according to actual conditions.

[0100] (2) Before each use, the tray needs to be calibrated, which is equivalent to the origin calibration, so that the injection needle 4 can be successfully inserted into the ampoule bottle 29 and in the middle of the ampoule bottle 29. The tray calibration angle is set to about 0.30-0.35 degrees. In this embodiment, it is specifically 0.35 degrees. It is adjusted according to the actual situation. After the calibration is completed, the packaging begins (the tray is the tray 28).

[0101] (3) The angle of the rotary valve 1 needs to be adjusted. Before each use, the angle of the rotary valve 1 needs to be observed to see whether the syringe 2 connected to the rotary valve 1 is vertically downward. If an angle deviation occurs, the liquid will not flow smoothly, affecting the precision and accuracy of the packaging.

[0102] The small-dose automatic filling equipment based on the PLC program provided in this embodiment has a simple structure, a small footprint, and strong mobility. It is used in conjunction with the 2mL ampoules in the laboratory of Tianjin Alta Technology Co., Ltd. The specifications, sizes, calibers and shapes of the ampoules are consistent with the tray in the equipment. Through the coordination of the rotary valve, syringe, and injection needle, while precisely controlling the rotary valve angle, injection needle depth, tray calibration angle, volume calibration and other conditions, accurate quantification and displacement of the liquid can be achieved. At the same time, the operation is simple and convenient, replacing manual filling operations, and realizing small-dose filling automation. Through actual application, it is found that the filling accuracy of the utility model has increased the filling accuracy of the traditional filling production line from ±2% to nearly ±0.1%, significantly improving the accuracy of filling.

[0103] Example 2 A PLC control system

[0104] The utility model provides a small-dose automatic filling device, which realizes automatic and precise filling based on a PLC control system. The PLC control system includes an initialization module, a data storage module, an input processing module, a logic control module, an output processing module, a communication module, a counting module, a timing module and a data processing module. The initialization module is connected to the data storage module, the input processing module and the logic control module through cables and a network. The logic control module is connected to the output processing module, the communication module, the counting module, the timing module and the data processing module through cables and a network. The modules have the following functions respectively:

[0105] 1. Initialization module: performs system initialization and parameter setting, including the server, wherein the server includes an Intel server CPU and a Windows network operating system.

[0106] 2. Data storage module: store data and back up.

[0107] 3. Input processing module: used to collect input signals from sensors, connect various sensors (such as liquid level sensors, position sensors, etc.) to the input port of PLC, and the sensor converts the detected physical quantity into electrical signals and inputs them into PLC.

[0108] 4. Logic control module: realize the logic control of the filling process, and realize automatic filling according to the set "parameter setting-cleaning-filling" process.

[0109] 5. Output processing module: control actuators, such as solenoid valves, motors, etc.

[0110] 6. Communication module: communicate with the host computer or other devices.

[0111] 7. Counting module: used to measure the filling quantity or cleaning times.

[0112] 8. Timing module: accurately control the filling time and interval of each ampoule during each filling.

[0113] 9. Data processing module: including flow sensor and flow meter, which collects filling volume information and feeds it back to PLC to achieve accurate measurement.

[0114] The working principle of the PLC control system is as follows: during initial use, parameters are set in the initialization module. After the setting is completed, the data storage module backs up the data and transmits the data to the input processing module. When filling is required, the PLC performs logical judgment based on the collected information, and the output processing module outputs the corresponding instructions, which reach each structure through the communication module, so that the equipment starts automatic filling; during the cleaning or filling process, the counting module completes the set number of cleaning times or filling quantities; the timing module accurately controls the filling time and interval of each ampoule bottle; the data processing module collects the filling volume information and feeds it back to the PLC, thereby achieving precise measurement.

[0115] Through the PLC control system provided in this embodiment, the editability of the entire filling equipment is greatly improved. The accuracy of the transmission between components can be accurately improved by fine-tuning the correction parameters according to the actual situation; a reasonable PLC control program can also be compiled according to production needs to cope with the increase and decrease of production, reasonably arrange the operating efficiency of the equipment, and extend the overall life of the equipment through manual flexible adjustment. The operation of this equipment can be made more accurate through the PLC control system. For example, it can ensure that the rotary valve, syringe, injection needle and the entire pipeline have been fully cleaned in the cleaning mode; ensure the accurate quantitative automatic filling, etc.

[0116] Example 3 Filling accuracy test of small-dose automatic filling equipment based on PLC program

[0117] In order to verify that the small-dose automatic filling equipment of the utility model can significantly improve the filling accuracy while realizing automatic filling, the following tests are performed in this embodiment:

[0118] 1. Normally operate the small-dose automatic filling equipment of the utility model, set the filling quantity of each batch to 10 bottles, the filling volume to 0.5 mL, and record the actual filling volume of each ampoule bottle 29 respectively, and compare it with the set value (0.5 mL);

[0119] 2. According to step 1, perform parallel tests 3 times and calculate the average value of the actual filling volume and filling accuracy of each batch;

[0120] 3. Set the filling volume to 1.2 mL. The remaining steps are the same as steps 1 and 2. Repeat the test and calculate the average value of the actual filling volume and filling accuracy of each batch.

[0121] 4. The small-dose automatic filling equipment of the utility model is not used, and manual filling is performed. Tests are performed according to steps 1-3 and the experimental results are recorded.

[0122] The specific results are shown in Table 1:

[0123] Table 1. Light filling accuracy test of the utility model small-dose automatic filling equipment

[0124]

[0125] Note: Filling accuracy = (actual filling volume - set filling volume) / set filling volume × 100%.

[0126] It can be seen from Table 1 that, compared with the traditional manual filling, the filling accuracy of the small-dose automatic filling equipment provided by the utility model is significantly improved, reaching nearly ±0.1%.

[0127] At the same time, in this embodiment, a commercially available automatic filling device is used to perform the measurement through the above steps. Since the small-dose automatic filling device provided by the utility model is specially designed for the specifications of the 2mL ampoule bottle in the laboratory of Tianjin Alta Technology Co., Ltd., its design perfectly matches the ampoule bottle. When using commercially available automatic filling equipment, it is obviously inconvenient to operate, the ampoule bottle cannot be placed, and it is very easy to hit the wall or liquid splash during packaging, thereby resulting in a significant reduction in filling accuracy.

[0128] Therefore, it can be seen that the optimal small-dose automatic filling equipment provided by the utility model can be perfectly used in conjunction with the corresponding ampoule bottle, thereby significantly improving the filling accuracy and achieving accurate quantification and displacement of the liquid.

[0129] Example 4 Structural optimization of small-dose automatic filling equipment based on PLC program

[0130] 1. Optimization of the syringe system structure

[0131] In order to successfully realize the precise automatic filling of 2mL ampoules in the laboratory, a set of small-dose automatic filling equipment based on PLC program is designed in the utility model. In the preliminary design, the structure and position of the syringe in the syringe system are optimized as follows (except for the structure of the syringe system, the other structures are as described in the optimal structural design in Example 1; in this embodiment, the "syringe-induced state" is defined as follows: when the syringe opening is facing downward and the rotary valve is below it, the syringe is in an inverted state; and when the syringe opening is facing upward and the rotary valve is above the syringe, the syringe is in a forward state):

[0132] 1. The specific structure of the syringe system is as described in the optimal structural design in Example 1: from top to bottom, it is a rotary valve and a syringe;

[0133] 2. From top to bottom, there are the syringe and the rotary valve. At this time, the syringe is in an inverted state, and its downward opening is tightly connected to the rotary valve. The first one-way valve on the rotary valve is connected to the liquid inlet pipeline, and the second one-way valve is connected to the liquid discharge pipeline. The liquid can enter the syringe upward through the liquid inlet pipeline, and then enter the liquid discharge pipeline through the second one-way valve under the push of the syringe.

[0134] In this embodiment, tests were carried out according to the above schemes. The experimental results show that when scheme 2 is selected, the structure has certain disadvantages:

[0135] 1. At this time, the syringe is in an inverted state. When the liquid is injected, it needs to overcome the gravity of the liquid to absorb the corresponding amount of liquid, which may lead to insufficient absorption and inaccurate absorption amount. It may also cause the pressure of the liquid inlet pipeline to be unstable, which may further lead to intermittent pauses and large fluctuations in the absorption amount during the absorption process.

[0136] 2. When discharging liquid, due to the effect of the liquid's own gravity, the liquid flows too fast when the syringe pushes the liquid, which may make it difficult to accurately control the amount of liquid discharged, or cause the liquid to be discharged at times fast or slow, or to be interrupted, which ultimately leads to inaccurate liquid quantification and other problems, and significantly reduces the filling accuracy.

[0137] When the optimal structure design in the preferred embodiment 1 is adopted, the above phenomenon will not occur, and the liquid can be accurately secondary quantified under the coordination of the syringe system and the injection needle system, which significantly improves the filling accuracy. Therefore, in this embodiment, the structural design of the syringe system in the preferred embodiment 1 is the optimal structure.

[0138] 2. Optimization of automatic filling module structure

[0139] In order to successfully realize the precise and automated filling of 2mL ampoules in the laboratory, a set of small-dose automatic filling equipment based on PLC program is designed in the utility model. In the preliminary design, the automatic filling module includes a syringe and a syringe pump. The syringe is connected to the syringe pump through a clamping structure. A valve is set at the bottom of the syringe. In the filling mode, the syringe pump drives the syringe to move downward, and the liquid to be filled enters the syringe barrel through the liquid inlet pipeline, and the valve is opened for packaging. However, under this design, the sealing degree of the valve is significantly reduced after long-term operation, which leads to leakage and significantly reduces the filling accuracy.

[0140] Therefore, in order to solve the above problems, in the subsequent structural design, the equipment structure is further optimized, a rotary valve and an injection needle structure are added to the automatic filling module, and the syringe structure is improved. The upper end of the syringe is connected to a rotary valve, and the syringe includes a syringe barrel, a piston, a push rod, and a push rod connector. The syringe is connected to the elastic structure inside the injection pump through the push rod connector at the bottom of the push rod. The first one-way valve and the second one-way valve are arranged on the rotary valve, and one end of the liquid inlet pipeline is connected to the first one-way valve, and the other end is connected to the container of the liquid to be filled; one end of the liquid discharge pipeline is connected to the second one-way valve, and the other end is connected to the injection needle. In the filling mode, when the first one-way valve is turned on, the second one-way valve is closed; or when the second one-way valve is turned on, the first one-way valve is closed (as described in the optimal structure in Example 1). After the structure is optimized, when the set volume of liquid to be filled enters the first one-way valve through the liquid inlet pipeline (at this time, the second one-way valve must be kept closed) and then enters the syringe, the syringe performs secondary quantification on the liquid to be filled. Through the cooperation of the syringe, the rotary valve, the first one-way valve and the second one-way valve, secondary quantification of the liquid to be filled can be achieved, which significantly improves the filling accuracy, thereby realizing accurate quantification and automatic filling of the liquid; at the same time, leakage can be avoided.

[0141] In the description of the present invention, it should be understood that the terms "center", "lateral", "up", "down", "left", "right", "front", "back", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0142] Although the present invention has been disclosed as above in terms of preferred embodiments, it is not intended to limit the present invention. Anyone familiar with the technology may make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention should be based on the definition of the claims.

Claims

1. A small-dose automatic filling equipment based on PLC program, characterized in that: It comprises an automatic filling module, which comprises a syringe system and an injection needle system. The syringe system comprises a valve, a syringe, and an injection pump. The valve and the syringe are combined into an integrated structure to complete the automatic absorption and discharge of liquid. The injection needle system comprises an injection needle, an injection needle fixing plate, a slider, a slider adapter plate, and a slide rail. The injection needle fixing plate, the slider, and the slider adapter plate are combined into an integrated structure. The injection needle is connected to the slider through the injection needle fixing plate, and the slider drives the injection needle to reciprocate on the slide rail to realize automatic filling of liquid. The valve is used for the circulation of liquid; the valve is provided with a first one-way valve and a second one-way valve; when the first one-way valve is turned on, the second one-way valve is closed; or when the second one-way valve is turned on, the first one-way valve is closed; the first one-way valve and the second one-way valve are used to control the filling accuracy and prevent the liquid from flowing back; Syringes are used for automatic aspiration and discharge of liquids; The syringe pump is used to provide power for the automatic aspiration and expulsion of the syringe.

2. The small-dose automatic filling equipment based on PLC program as claimed in claim 1 is characterized in that: The syringe is opened upward, and the valve is connected to the opening.

3. The small-dose automatic filling equipment based on PLC program as claimed in claim 2 is characterized in that: The syringe system also includes a liquid inlet pipeline and a liquid discharge pipeline. The first one-way valve is connected to one end of the liquid inlet pipeline, and the second one-way valve is connected to one end of the liquid discharge pipeline.

4. The small-dose automatic filling equipment based on PLC program as claimed in claim 3 is characterized in that: The syringe comprises a syringe barrel, a piston, a push rod, and a push rod connector. The syringe pump drives the push rod to reciprocate, driving the liquid to enter the syringe barrel through the first one-way valve.

5. The small-dose automatic filling equipment based on PLC program as claimed in claim 4 is characterized in that: The injection pump comprises an elastic structure, which is combined with the push rod into an integral structure through a push rod connector. The injection pump drives the push rod to perform reciprocating motion through the elastic structure.

6. The small-dose automatic filling equipment based on PLC program as claimed in claim 5 is characterized in that: The injection needle opens upward, and the opening is connected to one end of a liquid discharge pipeline for the circulation of liquid.

7. The small-dose automatic filling equipment based on PLC program as claimed in claim 6 is characterized in that: It also includes a filling system, which includes a positioning plate and a tray. The positioning plate and the tray are combined into an integrated structure for completing automatic batch filling of liquids.

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