Biopharmaceutical fermentation liquor pretreatment device

Abstract

The utility model discloses a biological pharmacy fermentation liquor pretreatment device, and relates to the technical field of biological pharmacy equipment. The bio-pharmaceutical fermentation liquor pretreatment device comprises an outer tank body, a feeding assembly, and a settling tank, an overflow pipe and a disinfection tank which are mounted in the outer tank body, and further comprises an outlet pipe group and a discharge valve group. The settling tank comprises an inner tank body, a floating filter plate, a sealing ring and a lifter; and the lifter is arranged below the floating filter plate. The floating filter plate is seamlessly and movably connected to the inner wall of the inner tank body through a sealing ring. And the feeding assembly leads to the floating filter plate. One end of the overflow pipe is communicated with the upper end of the inner tank body; and the outlet pipe group is communicated with the lower part of the disinfection tank. And the discharge valve group is mounted on the discharge pipe group. By using the device, fermentation liquor can be introduced from the feeding assembly, enters the settling tank and stands for settling, then the lifter ascends until supernatant liquid flows out of the overflow pipe to the disinfection tank, and the device realizes mechanical operation and collection of the supernatant liquid, and is convenient to operate.

Description

Technical Field

[0001] The present application relates to the technical field of biopharmaceutical equipment, and in particular to a biopharmaceutical fermentation liquid pretreatment device. Background Art

[0002] During the production of biopharmaceuticals, the fermentation broth needs to be pretreated. The pretreatment process includes letting the biopharmaceutical fermentation broth stand, and then taking the supernatant for disinfection and sterilization for the next step of production. Therefore, the pretreatment device is one of the essential equipment in the biopharmaceutical production process.

[0003] In the biopharmaceutical fermentation liquid pretreatment device of the related art, during the pretreatment process, after the fermentation liquid is allowed to stand, the supernatant liquid needs to be manually poured out to separate the supernatant liquid for the disinfection and sterilization process, which is not convenient enough. Utility Model Content

[0004] One of the purposes of the present application is to provide a biopharmaceutical fermentation liquid pretreatment device to solve the problem that the related pretreatment device proposed in the above background technology needs to manually pour out the upper clear liquid after the fermentation liquid is left to stand, separate the upper clear liquid for the disinfection and sterilization process, and the manual operation is not convenient enough.

[0005] To achieve the above objectives, this application provides the following technical solutions.

[0006] A biopharmaceutical fermentation liquid pretreatment device comprises: an outer tank body, a feed assembly installed on the outer tank body, a sedimentation tank, an overflow pipe and a disinfection tank installed in the outer tank body, and also comprises an outlet pipe group and an outlet valve group installed below the outer tank body.

[0007] The sedimentation tank includes an inner tank body, a floating filter plate, a sealing ring and a lifter. The sealing ring is installed on the periphery of the floating filter plate, and the lifter is installed below the floating filter plate. The floating filter plate is seamlessly and movably connected to the inner wall of the inner tank body through the sealing ring. The feed assembly leads to the floating filter plate. One end of the overflow pipe is connected to the upper end of the inner tank body, and the other end leads to the disinfection tank.

[0008] The outlet pipe group is connected to the bottom of the sterilizing tank. The outlet valve group is installed on the outlet pipe group.

[0009] By adopting the above technical solution and using the device, the fermentation liquid can be introduced from the feed component into the sedimentation tank, left to settle, and then the elevator rises until the upper clear liquid flows out from the overflow pipe into the disinfection tank. The device realizes mechanical operation to collect the supernatant, and the operation is convenient.

[0010] A preferred solution of the biopharmaceutical fermentation liquid pretreatment device is that the feed assembly includes a feed hopper and a discharge valve. The feed hopper is connected to the outer tank body and leads to the floating filter plate. The discharge valve is installed on the feed hopper.

[0011] By adopting the above technical solution and controlling the opening of the discharge valve, the feeding speed can be controlled, and external pollutants can be prevented from entering the outer tank body when not in use.

[0012] A preferred solution of the biopharmaceutical fermentation liquid pretreatment device is that the disinfection tank comprises a middle tank body and a heating plate. The heating plate is arranged on the inner peripheral wall of the middle tank body. The heating plate is connected to a temperature control system.

[0013] By adopting the above technical solution, the method of using heating means for disinfection and sterilization is simple and effective.

[0014] A preferred solution of the biopharmaceutical fermentation liquid pretreatment device is that the middle tank body is sleeved outside the inner tank body.

[0015] By adopting the above technical solution and interactively arranging various components, the entire processing device is made small in size.

[0016] A preferred embodiment of the biopharmaceutical fermentation liquid pretreatment device is that the outlet pipe group includes a drooping pipe, a large diameter pipe, a small diameter pipe and a discharge pipe. The upper end of the drooping pipe is connected to the lower end of the middle tank body, and the lower end of the drooping pipe is simultaneously connected to the front end of the large diameter pipe and the front end of the small diameter pipe. The rear end of the large diameter pipe and the rear end of the small diameter pipe are connected to the discharge pipe. The discharge valve group includes a first valve and a second valve. The first valve is installed at the connection between the large diameter pipe and the drooping pipe. The second valve is installed at the connection between the small diameter pipe and the drooping pipe.

[0017] By adopting the above technical scheme, the discharge pipe can be selected according to the discharge requirements and the consistency of the fermentation liquid. The fermentation liquid with a higher consistency enters the large-diameter pipe, reducing the risk of blockage and allowing the fermentation liquid with a higher consistency to pass better. On the contrary, it enters the interior of the small-diameter pipe, and the small-diameter pipe is used to increase the flow rate, so that the fermentation liquid with a lower viscosity can be discharged faster. Different pipes are selected for discharge according to the fermentation liquid of different consistencies, which facilitates the control of the fermentation liquid and improves the efficiency of discharge.

[0018] A preferred solution of the biopharmaceutical fermentation liquid pretreatment device is that the inner diameter of the large-diameter tube is 2 cm to 2.5 cm; and the inner diameter of the small-diameter tube is 0.5 cm to 1 cm.

[0019] By adopting the above technical solution, the two sizes of tubes can meet the discharge requirements of most fermentation liquids with different consistencies.

[0020] A preferred embodiment of the pretreatment device for biopharmaceutical fermentation broth is that the overflow pipe is in a U shape, including an upper horizontal section, a vertical section, and a lower horizontal section connected in sequence. The upper horizontal section communicates with the upper end of the inner tank body, the vertical section is fixedly attached to the outer wall of the inner tank body, and the lower horizontal section leads to the disinfection tank.

[0021] By adopting the above technical solution, the overflow pipe can be disassembled and assembled together with the inner tank body, which is convenient for disassembly and assembly.

[0022] A preferred embodiment of the pretreatment device for biopharmaceutical fermentation broth is that the disinfection tank has a bottom that slopes downward from the edge to the middle. The outlet pipe group communicates with the lowest point in the middle of the bottom of the disinfection tank.

[0023] By adopting the above technical solution, it is convenient for the automatic outflow of the fermentation broth and reduces residue.

[0024] Compared with the related technology, the beneficial effect of this application is that by using this device, the fermentation broth can be introduced through the feeding assembly and enter the sedimentation tank. After standing and sedimentation, the lifter rises until the supernatant flows out from the overflow pipe into the disinfection tank. This device realizes mechanical operation for collecting the supernatant, and the operation is convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the external structure of a pretreatment device for biopharmaceutical fermentation broth.

[0026] Figure 2 It is a cross-sectional view of the internal structure of a pretreatment device for biopharmaceutical fermentation broth.

[0027] Figure 3 It is a combined connection diagram of partial structures of a pretreatment device for biopharmaceutical fermentation broth.

[0028] Reference numerals in the drawings: outer tank body 1; feeding assembly 2; sedimentation tank 3; overflow pipe 4; disinfection tank 5; outlet pipe group 6; discharge valve group 7; inner tank body 31; floating filter plate 32; sealing ring 33; lifter 34; feeding hopper 21; blanking valve 22; middle tank body 51; heating plate 52; drooping pipe 61; large-diameter pipe 62; small-diameter pipe 63; discharge pipe 64; first valve 71; second valve 72; upper horizontal section 41; vertical section 42; lower horizontal section 43. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0029] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

[0030] A biopharmaceutical fermentation liquid pretreatment device is used for settling the fermentation liquid to take out the supernatant for pretreatment of sterilization and disinfection, and then discharge and collect it.

[0031] like Figure 1 The pretreatment device comprises: an outer tank body 1, and a feed assembly 2 installed on the outer tank body 1, such as Figure 2 The pretreatment device further comprises a sedimentation tank 3, an overflow pipe 4 and a disinfection tank 5 installed in the outer tank body 1, and also comprises an outlet pipe group 6 and an outlet valve group 7 installed below the outer tank body 1. The outer tank body 1 may be cylindrical.

[0032] The settling tank 3 includes an inner tank body 31, a floating filter plate 32, a sealing ring 33 and a lifter 34. The sealing ring 33 is installed on the periphery of the floating filter plate 32. The lifter 34 can be a lifting cylinder, and the lifter 34 is installed below the floating filter plate 32. The floating filter plate 32 is seamlessly and movably connected to the inner wall of the inner tank body 31 through the sealing ring 33. Preferably, the inner tank body 31 is cylindrical, and the floating filter plate 32 and the sealing ring 33 are both circular.

[0033] The feed assembly 2 leads to the floating filter plate 32. One end of the overflow pipe 4 is connected to the upper end of the inner tank body 31, and the other end leads to the disinfection tank 5. The floating filter plate 32 plays a role of floating filtration by pushing up the precipitated fermentation liquid so that the supernatant overflows and the precipitate remains on the floating filter plate 32.

[0034] The outlet pipe group 6 is connected to the bottom of the sterilizing tank 5. The discharge valve group 7 is installed on the outlet pipe group 6.

[0035] By using the device, the fermentation liquid can be introduced from the feed assembly 2 into the sedimentation tank 3, so that the flocs in the fermentation liquid can sink, and then the lifter 34 rises until the upper clear liquid flows out from the overflow pipe 4 into the disinfection tank 5, and the fermentation liquid is sterilized at high temperature inside the disinfection tank 5, and finally, the discharge valve group 7 is opened to discharge the fermentation liquid. The device realizes mechanical operation to collect the supernatant, and the device can automatically perform sedimentation filtration and disinfection pretreatment on the fermentation liquid, and is easy to operate.

[0036] In the pretreatment device, an optional structure of the feed assembly 2 is that the feed assembly 2 includes a feed hopper 21 and a discharge valve 22. The feed hopper 21 is connected to the outer tank body 1 and leads to the floating filter plate 32. The discharge valve 22 is installed on the feed hopper 21. Controlling the opening of the discharge valve 22 can control the feed speed and prevent external contaminants from entering the outer tank body 1 when not in use.

[0037] In this pretreatment device, the structure of the disinfection tank 5 may include a middle tank body 51 and a heating plate 52. The heating plate 52 is arranged around the inner peripheral wall of the middle tank body 51. The heating plate 52 is connected to a temperature control system. When the heating plate 52 is powered on, it generates heat to heat and sterilize the fermentation broth. This method of heating and disinfection is simple and effective.

[0038] In this pretreatment device, it is preferably designed that the middle tank body 51 is sleeved outside the inner tank body 31, so that the tank bodies are sleeved from the inside to the outside, with a compact layout, making the entire processing device small in volume.

[0039] In this pretreatment device, the structure of the outlet pipe group 6 may include a drooping pipe 61, a large-diameter pipe 62, a small-diameter pipe 63, and a discharge pipe 64. The upper end of the drooping pipe 61 communicates with the lower end of the middle tank body 51, and the lower end of the drooping pipe 61 communicates with the front end of the large-diameter pipe 62 and the front end of the small-diameter pipe 63 at the same time. The rear end of the large-diameter pipe 62 and the rear end of the small-diameter pipe 63 are connected to the discharge pipe 64. The discharge valve group 7 includes a first valve 71 and a second valve 72. The first valve 71 is installed at the connection between the large-diameter pipe 62 and the drooping pipe 61. The second valve 72 is installed at the connection between the small-diameter pipe 63 and the drooping pipe 61.

[0040] Based on the outlet pipe group 6 with the above structure, the discharge pipe 64 can be selected according to the discharge requirements and the consistency of the fermentation broth. The fermentation broth with a greater consistency enters the large-diameter pipe 62, reducing the risk of blockage and enabling the fermentation broth with a greater consistency to pass through better. On the contrary, it enters the inside of the small-diameter pipe 63. By using the small-diameter pipe 63 to increase the flow rate, the fermentation broth with a smaller consistency can be discharged more quickly. Selecting different pipes for discharging according to the fermentation broth with different consistencies facilitates the control of the fermentation broth and improves the efficiency of discharging.

[0041] Among them, the inner diameter of the large-diameter pipe 62 can be 2 cm to 2.5 cm; the inner diameter of the small-diameter pipe 63 can be 0.5 cm to 1 cm. These two sizes of pipes can meet the discharge requirements of most fermentation broths with different consistencies.

[0042] Combined Figure 2 and Figure 3 , in this pretreatment device, an optional structure of the overflow pipe 4 is in a C shape, including an upper horizontal section 41, a vertical section 42, and a lower horizontal section 43 connected in sequence. The upper horizontal section 41 communicates with the upper end of the inner tank body 31, the vertical section 42 is fixedly attached to the outer wall of the inner tank body 31, and the lower horizontal section 43 leads to the disinfection tank 5. The overflow pipe 4 with this structure and connection relationship can be disassembled and assembled together with the inner tank body 31, which is convenient to use.

[0043] In the pretreatment device, the sterilizing tank 5 is preferably designed to have a bottom that slopes downward from the edge to the middle. The outlet pipe group 6 is connected to the lowest point in the middle of the bottom of the sterilizing tank 5 to facilitate the automatic outflow of the fermentation liquid and reduce the residue of the fermentation liquid in the sterilizing tank 5.

[0044] The working principle of the pretreatment device is as follows: first, the fermentation liquid is poured from the feed hopper 21, the discharge valve 22 is opened to a certain opening, the fermentation liquid enters the interior of the sedimentation tank 3, and the fermentation liquid is statically settled by the sedimentation tank 3. After the sedimentation is completed, the floating filter plate 32 is raised by starting the lifting cylinder. As the floating filter plate 32 continues to rise, the horizontal surface will continue to rise, and then reach the position of the overflow pipe 4, and then flow into the interior of the disinfection tank 5 through the overflow pipe 4. Secondly, the heat conduction plate is made of copper material, and the temperature is increased by power, and the fermentation liquid is sterilized at high temperature. The sterilized fermentation liquid flows into the drooping pipe 61 through the drooping pipe 61, and the discharge pipe 64 is selected according to the discharge requirements and the consistency of the fermentation liquid. For the fermentation liquid with a larger consistency, the first valve 71 is opened, and the fermentation liquid enters the large diameter pipe 62, and finally discharged and collected through the discharge pipe 64. For the fermentation liquid with a smaller consistency, the second valve 72 is opened, and the fermentation liquid enters the small diameter pipe 63, and finally discharged and collected through the discharge pipe 64.

[0045] The above is only a preferred specific implementation manner of the present application, but the protection scope of the present application is not limited thereto. Any technician familiar with the technical field can make equivalent substitutions or changes within the technical scope disclosed in the present application according to the technical solution and application concept of the present application, which should be covered by the protection scope of the present application.

Claims

1. A biopharmaceutical fermentation liquid pretreatment device, characterized in that: Comprising: An outer tank body (1), a feeding assembly (2) installed on the outer tank body (1), a settling tank (3), an overflow pipe (4) and a disinfection tank (5) installed inside the outer tank body (1), and further comprising a discharge pipe group (6) and a discharge valve group (7) installed below the outer tank body (1); The settling tank (3) includes an inner tank body (31), a floating filter plate (32), a sealing ring (33) and a lifter (34); the sealing ring (33) is installed on the periphery of the floating filter plate (32), and the lifter (34) is installed below the floating filter plate (32); the floating filter plate (32) is seamlessly and movably connected to the inner wall of the inner tank body (31) through the sealing ring (33); the feeding assembly (2) leads to the floating filter plate (32); one end of the overflow pipe (4) is communicated with the upper end of the inner tank body (31), and the other end leads to the disinfection tank (5); The discharge pipe group (6) is communicated with the lower part of the disinfection tank (5); the discharge valve group (7) is installed on the discharge pipe group (6).

2. The biopharmaceutical fermentation liquid pretreatment device according to claim 1, characterized in that: The feeding assembly (2) includes a feeding hopper (21) and a blanking valve (22); the feeding hopper (21) is communicated with the outer tank body (1) and leads to the floating filter plate (32); the blanking valve (22) is installed on the feeding hopper (21).

3. The biopharmaceutical fermentation liquid pretreatment device according to claim 1, characterized in that: The disinfection tank (5) includes a middle tank body (51) and a heating plate (52); the heating plate (52) is arranged around the inner peripheral wall of the middle tank body (51); the heating plate (52) is connected to a temperature control system.

4. The biopharmaceutical fermentation liquid pretreatment device according to claim 3, characterized in that: The middle tank body (51) is sleeved outside the inner tank body (31).

5. The biopharmaceutical fermentation liquid pretreatment device according to claim 3, characterized in that: The discharge pipe group (6) includes a drooping pipe (61), a large-diameter pipe (62), a small-diameter pipe (63) and a discharge pipe (64); the upper end of the drooping pipe (61) is communicated with the lower end of the middle tank body (51), and the lower end of the drooping pipe (61) is simultaneously communicated with the front end of the large-diameter pipe (62) and the front end of the small-diameter pipe (63); the rear end of the large-diameter pipe (62) and the rear end of the small-diameter pipe (63) are connected to the discharge pipe (64); The discharge valve group (7) includes a first valve (71) and a second valve (72); the first valve (71) is installed at the connection between the large-diameter pipe (62) and the drooping pipe (61); the second valve (72) is installed at the connection between the small-diameter pipe (63) and the drooping pipe (61).

6. The biopharmaceutical fermentation liquid pretreatment device according to claim 5, characterized in that: The inner diameter of the large-diameter pipe (62) is 2 cm to 2.5 cm; the inner diameter of the small-diameter pipe (63) is 0.5 cm to 1 cm.

7. The biopharmaceutical fermentation liquid pretreatment device according to claim 1, characterized in that: The overflow pipe (4) is in a C shape, including an upper horizontal section (41), a vertical section (42) and a lower horizontal section (43) connected in sequence; the upper horizontal section (41) is communicated with the upper end of the inner tank body (31), the vertical section (42) is fixedly attached to the outer wall of the inner tank body (31), and the lower horizontal section (43) leads to the disinfection tank (5).

8. The biopharmaceutical fermentation liquid pretreatment device according to claim 1, characterized in that: The disinfection tank (5) has a bottom that slopes downward from the edge to the middle; the discharge pipe group (6) is communicated with the lowest position in the middle of the bottom of the disinfection tank (5).

Images