Filling and film sealing equipment for extracting card box

Abstract

The utility model belongs to the field of filling and sealing, and particularly relates to extraction card box filling and film sealing equipment which comprises a station switching device, a first film sealing device, a turnover device, a reagent filling device and a second film sealing device. The first film sealing device is used for conducting film sealing on the bottom of the extraction card box located on the first film sealing station. And the overturning device is used for overturning the extraction card box on the overturning station, so that the top of the extraction card box is upwards positioned on the carrying seat. And the reagent filling device is used for filling reagents into the extraction clamping boxes on the reagent filling station. The second film sealing device is used for conducting film sealing on the top of the extraction card box located on the second film sealing station. The equipment can replace manual work to sequentially conduct bottom film sealing, filling and top film sealing on the extraction clamping box, the labor cost is reduced, the performance consistency is good, the appearance is uniform, the product quality and the production efficiency are improved, and the possibility that the extraction clamping box is polluted in the filling and film sealing process is reduced.

Description

Technical Field

[0001] The present application relates to the field of filling and sealing technology, and in particular to an extraction cartridge filling and sealing device. Background Art

[0002] In molecular diagnostics, extraction cartridges are increasingly used, such as Figure 1 As shown, the extraction cartridge has multiple different partitions, which are used to hold a variety of different reagents. At present, most standard cartridges are manually filled by means of a pipette pump. In the process of manually filling the reagents, it is difficult to accurately grasp the amount of reagents to be filled, and it is easy to introduce dust and other impurities during the filling process, causing pollution to the reagents. Before filling, the bottom of the cartridge needs to be manually sealed and welded, and the mouth sealing is manually welded after filling. It should be noted that the technical process requirements for the cartridge sealing are relatively high. Once the quality of the sealing film does not meet the standards, it will directly affect the sealing of the filled reagents and cause leakage. The leakage will cause the partition reagents to mix in advance, thereby affecting the accuracy of the subsequent detection cartridges when used for testing. The sealing and stability consistency of the manual laminating operation is poor. In the case of unstable laminating, when the film is punctured for sampling, it will also affect the actual operational reliability, thereby affecting the entire detection operation process. In addition, the transfer of the extraction cartridge between the bottom sealing, reagent filling, and top sealing processes is usually achieved manually, that is, the operator manually moves the filled extraction cartridge to the aluminum film welding process. Manual transfer of extraction cartridges between processes not only has low production efficiency, but also requires more operators, resulting in high production costs. Failure to seal the film in time after the reagent filling is completed can easily cause contamination and affect product quality. That is, the existing filling and sealing operations have poor stability, consume a lot of labor costs, are inefficient, and have the possibility of contamination, thereby affecting the extraction effect of the reagent itself. Utility Model Content

[0003] The embodiment of the present application provides an extraction cartridge filling and sealing device, which aims to improve the reliability and consistency of the filling and sealing of the extraction cartridge, improve production efficiency, and reduce the possibility of contamination.

[0004] To achieve the above-mentioned purpose, the present application provides an extraction cartridge filling and sealing device, the extraction cartridge filling and sealing device comprising:

[0005] The station switching device comprises a conveying mechanism and a plurality of carriers arranged on the conveying mechanism for positioning the extraction cartridge, wherein the plurality of carriers can sequentially pass through the sample loading station, the first film sealing station, the flipping station, the reagent filling station, the second film sealing station and the sample unloading station under the action of the conveying mechanism;

[0006] At the sample loading station, the extraction cartridge is positioned on the carrier with the bottom facing upwards;

[0007] A first film sealing device, used for sealing the bottom of the extraction cartridge at the first film sealing station;

[0008] A flipping device, used for flipping the extraction card box on the flipping station so that the top of the extraction card box is positioned upward on the carrier;

[0009] a reagent filling device, used for filling the extraction cartridge at the reagent filling station with reagent; and

[0010] The second film sealing device is used to seal the top of the extraction cartridge located at the second film sealing station.

[0011] Optionally, the conveying mechanism includes a turntable and a driving mechanism for driving the turntable to rotate, and a plurality of the carriers are evenly arranged on the turntable along the circumferential direction.

[0012] Optionally, the carrier includes a bottom plate, a top plate, a guide column, an elastic member and a seat body, the guide column passes through the conveying mechanism up and down, the top plate and the bottom plate are respectively arranged at the upper and lower ends of the guide column, the elastic member is arranged between the top plate and the conveying mechanism, the seat body is arranged on the top plate, and a positioning groove for positioning the extraction card box is arranged on the top of the seat body.

[0013] Optionally, the extraction cartridge filling and sealing equipment further comprises a detection device, and a detection station is further provided between the loading station and the first sealing station, and the detection device is used to detect whether there is an extraction cartridge on the carrier located on the detection station.

[0014] Optionally, the first film sealing device includes a film unwinding mechanism, a winding mechanism, and a punching mechanism and a heat sealing mechanism arranged between the film unwinding mechanism and the winding mechanism, the film unwinding mechanism releases the aluminum foil film by rotating the aluminum foil roll, the punching mechanism is used to cut the packaging film that is compatible with the extraction card box at breakpoints on the aluminum foil film, the heat sealing mechanism is used to hot-press weld the packaging film from the aluminum foil film to the extraction card box, and the winding mechanism is used to pull and roll up the waste film.

[0015] Optionally, the punching mechanism comprises a lower template, a punching drive and an upper template, the punching drive is arranged above the lower template, the upper template is arranged on the punching drive, and the upper template can be driven by the punching drive to approach or move away from the lower template, and the upper template and the lower template are provided with knives for cutting aluminum foil film on the relative inner sides, and the aluminum foil film released by the film releasing mechanism passes between the upper template and the lower template; and / or,

[0016] The heat sealing mechanism includes a pressing plate, a receiving plate, a heat sealing block, and a hot pressure lifting module. The pressing plate and the receiving plate are spaced apart above the first film sealing station. A gap is provided between the pressing plate and the receiving plate for allowing the aluminum foil film to pass through. Both the pressing plate and the receiving plate are provided with avoidance holes that match the shape of the packaging film. The hot pressure lifting module is provided above the pressing plate. The heat sealing block is provided at the moving end of the hot pressure lifting module. A heating element is provided in the heat sealing block. The heat sealing block can move up and down under the drive of the hot pressure lifting module to punch the packaging film out of the avoidance hole and weld it to the extraction box.

[0017] Optionally, the second film sealing device has the same structure as the first film sealing device.

[0018] Optionally, the flipping device includes a lifting mechanism, a rotating mechanism arranged on the lifting mechanism, and a clamping mechanism arranged on the rotating mechanism, and the clamping mechanism can move up and down under the action of the lifting mechanism and flip up and down under the action of the rotating mechanism.

[0019] Optionally, the reagent filling device includes a plurality of liquid storage tanks, a plurality of injection needles, and a plurality of infusion tubes that connect the plurality of liquid storage tanks and the plurality of injection needles in a one-to-one correspondence, and liquid is transported between the liquid storage tanks and the injection needles via a pressure difference or a pump.

[0020] Optionally, the reagent filling device further comprises a mounting plate and a lifting drive for driving the mounting plate to move up and down to approach or move away from the reagent filling station, and the plurality of injection needles are mounted on the mounting plate.

[0021] The beneficial effect of the extraction card box filling and sealing device provided by the present application is that: compared with the prior art, the extraction card box filling and sealing device of the present application includes a station switching device for switching the extraction card box between the loading station, the first sealing station, the flipping station, the reagent filling station, the second sealing station and the unloading station, and the first sealing device, the flipping device, the reagent filling device and the second sealing device corresponding to the corresponding station are set, and the extraction card box is switched in each station through the station switching device, and the bottom sealing of the extraction card box, the reagent filling, the top sealing of the extraction card box and other operations are completed in sequence through the device corresponding to the corresponding station, which can replace the manual filling and sealing operations of the extraction card box, reduce the circulation process between each process, improve production efficiency, and be suitable for industrial realization of mass production. Automatic filling of reagents by the reagent filling device can not only accurately control the amount of reagents, but also do not involve manual filling, and will not introduce dust and other impurities during the filling process, thereby ensuring the cleanliness of the reagents. Since the laminating operation at both ends of the extraction card box is completed by the first sealing device and the second sealing device, compared with manual operation, the sealing and stability of the extraction card box after laminating are more reliable, the product consistency is good, and the qualified rate of the product is improved. In summary, the design of the extraction card box filling and sealing equipment is reasonable, which reduces the possibility of contamination during the filling and sealing process and ensures product quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0023] in:

[0024] Figure 1 1 is a schematic diagram of the structure of the top and bottom of the extraction cartridge;

[0025] Figure 2 It is a structural schematic diagram of an extraction cartridge filling and sealing device shown in an embodiment of the present application;

[0026] Figure 3 It is a schematic diagram of the internal structure of an extraction cartridge filling and sealing device shown in one embodiment of the present application;

[0027] Figure 4 yes Figure 3 A schematic diagram of the structure from above;

[0028] Figure 5 It is a structural schematic diagram of a station switching device in an extraction cartridge filling and sealing device shown in an embodiment of the present application;

[0029] Figure 6 It is a structural schematic diagram of a carrier in a workstation switching device shown in one embodiment of the present application;

[0030] Figure 7 It is a schematic diagram of the structure of a detection device in an extraction cartridge filling and sealing device shown in an embodiment of the present application;

[0031] Figure 8 It is a structural schematic diagram of a first film sealing device in an extraction cartridge filling and sealing device according to an embodiment of the present application;

[0032] Fig. 9 It is a schematic structural diagram of a flipping device in an extraction cartridge filling and sealing device according to an embodiment of the present application;

[0033] Fig.10 It is a schematic structural diagram of a reagent filling device in an extraction cartridge filling and sealing device shown in an embodiment of the present application;

[0034] Fig.11 It is a schematic structural diagram of the cooperation between the reagent filling device and the station switching device in the extraction cartridge filling and sealing device shown in one embodiment of the present application;

[0035] Fig.12 It is a structural schematic diagram of a material unloading and handling device in an extraction card box filling and sealing device shown in an embodiment of the present application.

[0036] Description of main component symbols:

[0037] 10. Sample loading station; 20. Testing station; 30. First film sealing station; 40. Turning station; 50. Reagent filling station; 60. Second film sealing station; 70. Sample unloading station;

[0038] 100, station switching device; 110, conveying mechanism; 111, turntable; 112, driving mechanism; 120, carrier; 121, bottom plate; 122, top plate; 123, guide column; 124, elastic member; 125, seat body; 1251, positioning groove; 126, linear bearing;

[0039] 200, detection device; 210, bracket; 220, lifting cylinder; 230, pressing block;

[0040] 300, first film sealing device; 310, vertical plate; 320, film placing mechanism; 330, winding mechanism; 340, punching mechanism; 341, lower template; 342, punching driving member; 343, upper template; 350, heat sealing mechanism; 351, material pressing plate; 352, material receiving plate; 353, heat sealing block; 354, heat pressing lifting module; 360, guide roller;

[0041] 400, turning device; 410, lifting mechanism; 420, rotating mechanism; 430, clamping mechanism;

[0042] 500, reagent filling device; 510, liquid storage tank; 520, injection needle; 530, peristaltic pump; 540, stirring mechanism; 550, mounting plate; 560, lifting drive;

[0043] 600, second film sealing device;

[0044] 700, material unloading and handling device; 710, rotating and lifting mechanism; 720, clamping claw;

[0045] 800, unloading conveyor;

[0046] 900, equipment frame; 910, load-bearing frame; 911, mounting table; 920, outer shell; 921, loading window; 922, unloading window. DETAILED DESCRIPTION

[0047] In order to facilitate the understanding of the present application, the present application will be described more comprehensively with reference to the relevant drawings below. The preferred embodiments of the present application are provided in the drawings. However, the present application can be implemented in many other different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive.

[0048] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

[0049] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0050] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of this application, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0051] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those generally understood by those skilled in the art to which the present application belongs. The terms used herein in the specification of the present application are only for the purpose of describing specific embodiments and are not intended to limit the present application. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0052] It should also be noted that, in the embodiments of the present application, the same figure mark is used to represent the same component or the same part. For the same parts in the embodiments of the present application, the figure may only mark one of the parts or components as an example. It should be understood that the figure mark also applies to other identical parts or components.

[0053] The embodiment of the present application provides an extraction cartridge filling and sealing device, such as Figure 2-Figure 4 As shown, the extraction cartridge filling and sealing device includes a station switching device 100 , a first sealing device 300 , a turning device 400 , a reagent filling device 500 and a second sealing device 600 .

[0054] The station switching device 100 includes a conveying mechanism 110 and a plurality of carriers 120 for positioning the extraction cartridges arranged on the conveying mechanism 110. The plurality of carriers 120 can sequentially pass through the loading station 10, the first film sealing station 30, the flipping station 40, the reagent filling station 50, the second film sealing station 60 and the unloading station 70 under the action of the conveying mechanism 110. At the loading station 10, the bottom of the extraction cartridge can be positioned upward on the carrier 120 manually or by an automatic loading mechanism. The first film sealing device 300 is used to seal the bottom of the extraction cartridge at the first film sealing station 30. The flipping device 400 is used to flip the extraction cartridge at the flipping station 40 so that the top of the extraction cartridge is positioned upward on the carrier 120. The reagent filling device 500 is used to fill the reagent into the extraction cartridge at the reagent filling station 50. The second film sealing device 600 is used to seal the top of the extraction cartridge on the second film sealing station 60 .

[0055] The working process of the extraction card box filling and sealing device is as follows: the extraction card box is placed on the carrier 120 of the station switching device 100 with the bottom facing upward at the sample loading station 10, and the conveying mechanism 110 of the station switching device 100 drives the extraction card box to move to the first sealing station 30, and the first sealing device 300 seals the bottom of the extraction card box. The conveying mechanism 110 continues to move, driving the extraction card box to move to the flipping station 40, and the flipping device 400 flips the extraction card box so that its top faces upward. The conveying mechanism 110 continues to move, driving the extraction card box to move to the reagent filling station 50, and the reagent filling device 500 fills the extraction card box with reagent. Finally, the conveying mechanism 110 moves the extraction card box to the second sealing station 60, and the second sealing device 600 seals the top of the extraction card box.

[0056] In the embodiment of the present application, the extraction cartridge filling and sealing device includes a station switching device 100 for switching the extraction cartridge between the loading station 10, the first sealing station 30, the flipping station 40, the reagent filling station 50, the second sealing station 60 and the unloading station 70, and the first sealing device 300, the flipping device 400, the reagent filling device 500 and the second sealing device 600 corresponding to the corresponding stations. The station switching device 100 is used to realize the switching of the extraction cartridge in each station, and the bottom sealing of the extraction cartridge, the reagent filling, the top sealing of the extraction cartridge and other operations are completed in sequence by the devices corresponding to the corresponding stations. The extraction cartridge can be filled and sealed manually instead of manually, and the circulation process between each process is reduced, the labor cost is reduced, and the production efficiency is improved. The reagent is automatically filled by the reagent filling device 500, which can not only accurately control the amount of the reagent, but also does not involve manual work, and does not introduce impurities such as dust during the filling process, thereby ensuring the cleanliness of the reagent. In addition, since the film coating operation at both ends of the extraction card box is completed by the first film sealing device 300 and the second film sealing device 600, compared with manual operation, the sealing and stability of the extraction card box after coating are more reliable, the product performance consistency is good, the appearance is uniform, and the qualified rate of the product is improved. In summary, the extraction card box filling and sealing equipment is reasonably designed, which reduces the possibility of contamination during the filling and sealing process, ensures product quality, and can be operated by a single person (for loading or replenishing film rolls and reagents), without the need for matching professional technicians, and is suitable for industrial realization of mass production.

[0057] It is understandable that the extraction card box filling and sealing equipment also has a control device (such as a PLC controller) for unified and coordinated control of the workstation switching device 100, the first sealing device 300, the flipping device 400, the reagent filling device 500 and the second sealing device 600.

[0058] The extraction cartridge filling and sealing device also includes a device frame 900, which includes a load-bearing frame 910, a mounting plate 911 disposed on the load-bearing frame 910, and a housing 920. The station switching device 100, the first sealing device 300, the flipping device 400, the reagent filling device 500, and the second sealing device 600 are all disposed on the mounting plate 911 and covered in the housing 920. The housing 920 is also provided with a loading window 921 for loading the extraction cartridge and a unloading window 922 for unloading the finished product after filling. When manual loading is adopted, a safety grating is provided on the loading window 921 to improve the safety of the device.

[0059] In one embodiment, if Figure 3-Figure 5 As shown, the conveying mechanism 110 includes a turntable 111 and a driving mechanism 112 for driving the turntable 111 to rotate, and a plurality of carriers 120 are evenly arranged on the turntable 111 along the circumferential direction.

[0060] The conveying mechanism 110 is composed of a turntable 111 driven by a driving mechanism 112, and is arranged around the turntable 111 in cooperation with a first sealing device 300, a flipping device 400, a reagent filling device 500 and a second sealing device 600. The turntable 111 can realize the cyclic switching of the workstations under the drive of the driving mechanism 112, so that the entire extraction card box filling and sealing equipment is small in size and compact in structure, reducing the footprint.

[0061] Specifically, the horizontally arranged turntable 111 is rotatably arranged on the mounting plate 911 and is driven to rotate by the driving mechanism 112. Twelve carriers 120 evenly distributed along the circumference of the turntable 111 are installed on the top surface of the turntable 111. The driving mechanism 112 uses a reduction motor to drive the turntable 111 to rotate 30° each time.

[0062] Of course, it is conceivable that in other embodiments, the conveying mechanism 110 can also adopt a conveyor belt, and multiple carriers 120 are evenly arranged on the conveyor belt along the length direction of the synchronous belt, and the first sealing device 300, the flipping device 400, the reagent filling device 500 and the second sealing device 600 are distributed on both sides of the length direction of the conveyor belt, and the switching of the workstations is realized through the step-by-step operation of the synchronous belt.

[0063] In one embodiment, if Figure 5-Figure 6 As shown, the carrier 120 includes a bottom plate 121, a top plate 122, a guide column 123, an elastic member 124 and a seat body 125. The guide column 123 passes through the conveying mechanism 110 from top to bottom. The top plate 122 and the bottom plate 121 are respectively arranged at the upper and lower ends of the guide column 123. The elastic member 124 is arranged between the top plate 122 and the conveying mechanism 110. The seat body 125 is arranged on the top plate 122. A positioning groove 1251 for positioning the extraction box is arranged on the top of the seat body 125.

[0064] Specifically, a through hole is provided on the turntable 111 of the conveying mechanism 110, which passes through the turntable 111 from top to bottom. The guide post 123 is inserted into the through hole and the length of the guide post 123 is greater than the thickness of the turntable 111. The top plate 122 and the bottom plate 121 are respectively located on the upper and lower sides of the turntable 111 and are respectively fixed to the upper and lower ends of the guide post 123. The elastic member 124 is a spring, which is sleeved on the guide post 123, and the upper and lower ends of the spring are respectively in contact with the lower surface of the top plate 122 and the upper surface of the turntable 111. Further, in order to reduce the friction between the guide post 123 and the through hole, a linear bearing 126 is provided between the guide post 123 and the through hole.

[0065] The carrier 120 is designed as above, so that during the hot pressing and film sealing process, the pressure applied to the extraction card box can drive the carrier 120 to overcome the elastic downward movement of the elastic member 124, and the elastic member 124 plays a certain buffering role, thereby preventing the downward pressure applied by the heat sealing block 353 during the hot pressing process from directly acting on the turntable 111, thereby avoiding the problem of deformation of the turntable 111 during long-term operation, and improving the stability and life of the equipment.

[0066] In one embodiment, if Figure 3-Figure 4 As shown, the extraction cartridge filling and sealing equipment also includes a detection device 200. A detection station 20 is also provided between the loading station 10 and the first sealing station 30. The detection device 200 is used to detect whether there is an extraction cartridge on the carrier 120 located on the detection station 20, so as to avoid subsequent sealing, filling and other operations on the corresponding carrier 120 where no extraction cartridge is present.

[0067] Specifically, the detection device 200 can be a photoelectric sensor, or a Figure 7 The structure shown includes a bracket 210, a lifting cylinder 220 disposed on the bracket 210 with the piston end facing downward, a pressure block 230 disposed on the piston end, and a pressure sensor (not shown in the figure) disposed on the pressure block 230. When the conveying mechanism 110 of the station switching device 100 drives the carrier 120 to move to the detection station 20, the lifting cylinder 220 drives the pressure block 230 to descend to a preset height, and the pressure sensor detects whether the pressure block 230 presses on an object and then determines whether there is an extraction card box on the carrier 120. When the presence of the extraction card box is detected, the control device controls each part to continue the action; when the absence of the extraction card box is detected, the control device controls each part to suspend the action and controls the alarm to give an alarm prompt.

[0068] In one embodiment, if Figure 3 and Figure 8As shown, the first film sealing device 300 includes a film unwinding mechanism 320, a winding mechanism 330, and a punching mechanism 340 and a heat sealing mechanism 350 arranged between the film unwinding mechanism 320 and the winding mechanism 330. The film unwinding mechanism 320 releases the aluminum foil film by rotating the aluminum foil roll. The punching mechanism 340 is used to cut the packaging film that is compatible with the extraction card box at breakpoints on the aluminum foil film. It should be noted here that the breakpoint cutting means that the packaging film is not completely separated from the aluminum foil film, but is connected together through several points and can move with the aluminum foil film. The heat sealing mechanism 350 is used to hot-press and weld the packaging film from the aluminum foil film to the extraction card box, and the winding mechanism 330 is used to pull and roll up the waste film.

[0069] The first film sealing device 300 can realize continuous and uninterrupted film coating operation on the extraction card box entering the first film sealing station 30 through the mutual cooperation of the film placing mechanism 320, the winding mechanism 330, the punching mechanism 340 and the heat sealing mechanism 350, and the coating efficiency is high. In addition, the first film sealing device 300 is used to replace manual coating, which improves the stability and reliability of the coating, and the product performance consistency is good, which avoids the subsequent leakage that causes the premature mixing of the partition reagents and affects the accuracy of the extraction card box during use and detection.

[0070] Specifically, the film unwinding mechanism 320, the winding mechanism 330, the punching mechanism 340 and the heat sealing mechanism 350 are arranged together on a vertical plate 310, and the film unwinding mechanism 320 includes a film unwinding motor and a film unwinding shaft. The film unwinding motor is installed on the vertical plate 310 and the machine shaft is connected to the film unwinding shaft. The aluminum foil roll is sleeved on the film unwinding shaft. The film unwinding motor drives the film unwinding shaft to rotate, thereby releasing the aluminum foil film. The winding mechanism 330 includes a winding motor and a waste film reel. The winding motor is installed on the vertical plate 310, and the output shaft of the winding motor is connected to the waste film reel. The winding motor drives the waste film reel to rotate, thereby pulling the waste film out of the punching mechanism 340 and the heat sealing mechanism 350 and winding the waste film on the waste film reel. While the film unwinding mechanism 320 releases the aluminum foil film, the winding mechanism 330 rewinds the waste film. Since the aluminum foil film is relatively thin, in order to ensure that the released aluminum foil film is always in a fully stretched state, a plurality of guide rollers 360 are provided on the vertical plate 310. The released aluminum foil film is wound around each guide roller 360, and the guide rollers 360 play a tensioning role to improve the film sealing effect.

[0071] In a specific embodiment, Figure 8As shown, the punching mechanism 340 includes a lower template 341, a punching drive 342 and an upper template 343. The punching drive 342 is arranged above the lower template 341, and the upper template 343 is arranged on the punching drive 342. The upper template 343 can approach or move away from the lower template 341 under the drive of the punching drive 342. The upper template 343 and the lower template 341 are provided with knives for cutting the aluminum foil film on the opposite inner sides. The aluminum foil film released by the film release mechanism 320 passes between the upper template 343 and the lower template 341. Among them, the lower template 341 is installed on the vertical plate 310 through the lower pad plate, and the upper template 343 is connected to the driving end of the punching drive 342 through the upper mold connecting plate. The upper template 343 presses the aluminum foil film on the lower template 341 under the drive of the punching drive 342, and the packaging film is cut out on the aluminum foil film by the knives on the upper template 343 and the lower template 341. Specifically, the punching drive member 342 can be a mechanism capable of reciprocating linear motion, such as a linear cylinder or an electric push rod.

[0072] The heat sealing mechanism 350 includes a pressing plate 351, a receiving plate 352, a heat sealing block 353, and a heat pressing lifting module 354. The pressing plate 351 and the receiving plate 352 are spaced apart above the first film sealing station 30. A gap is provided between the pressing plate 351 and the receiving plate 352 for allowing the aluminum foil film to pass through. The pressing plate 351 and the receiving plate 352 are both provided with avoidance holes that match the shape of the packaging film. The setting of the pressing plate 351 and the receiving plate 352 can limit the aluminum foil film other than the packaging film in the stamping direction of the heat sealing block 353, thereby ensuring that the packaging film can be completely punched off and separated from the aluminum foil film. At the same time, it also avoids the remaining aluminum foil film from being In the case where the foil film (i.e., waste film) breaks during the stamping process, and the reeling mechanism 330 cannot continuously roll up the waste film, the hot pressure lifting module 354 is arranged above the pressing plate 351, and the heat sealing block 353 is arranged at the moving end of the hot pressure lifting module 354. The heat sealing block 353 has a heating element and a temperature sensor. The heating element heats the heat sealing block 353. The temperature sensor is used to detect the temperature of the heat sealing block 353 in real time and transmit a feedback signal to the control device. The control device is electrically connected to the heating element and controls the heating element in real time according to the temperature signal to ensure that the heat sealing block 353 always remains within the sealing temperature range. The heat sealing block 353 can move up and down under the drive of the hot pressure lifting module 354 to press the packaging film down from the avoidance hole and weld it to the extraction card box. The bottom surface of the heat sealing block 353 forms a heating and pressing plane. During the sealing process, the heating and pressing plane presses the packaging film and heats it, thereby welding the packaging film and the extraction card box together. Specifically, the hot pressing lifting module 354 can adopt a mechanism capable of reciprocating linear motion, such as a linear cylinder or an electric push rod.

[0073] In a specific embodiment, Figure 3 and Figure 4As shown, the second film sealing device 600 has the same structure as or a mirror image of the first film sealing device 300 .

[0074] In one embodiment, if Figure 4 and Fig. 9 As shown, the flipping device 400 includes a lifting mechanism 410, a rotating mechanism 420 disposed on the lifting mechanism 410, and a clamping mechanism 430 disposed on the rotating mechanism 420. The clamping mechanism 430 can move up and down under the action of the lifting mechanism 410 and flip up and down under the action of the rotating mechanism 420.

[0075] After the extraction card box passes through the first film sealing station 30 and the bottom of the extraction card box is sealed by the first film sealing device 300, it needs to be turned over, that is, the top opening of the extraction card box faces upward, so as to facilitate the filling of reagents at the reagent filling station 50.

[0076] The flipping device 400 has a simple structure and consists of three parts: a lifting mechanism 410, a rotating mechanism 420 and a clamping mechanism 430. When the extraction card box after the bottom film is sealed moves to the flipping station 40 under the drive of the station switching device 100, the lifting mechanism 410 drives the rotating mechanism 420 and the clamping mechanism 430 located thereon to descend, and then the clamping mechanism 430 clamps the extraction card box on the carrier 120, and the lifting mechanism 410 drives the clamped extraction card box to escape from the carrier 120 and rise to a certain height, and then the rotating mechanism 420 drives the clamping mechanism 430 and the clamped extraction card box to flip 180°, and then the lifting mechanism 410 drives the clamped extraction card box to descend and fall onto the carrier 120, and finally, the clamping mechanism 430 releases the extraction card box, and the entire flipping device 400 is reset.

[0077] Specifically, the lifting mechanism 410 may adopt a linear cylinder or an electric cylinder, the rotating mechanism 420 may adopt a rotary cylinder or a rotary motor, and the clamping mechanism 430 may adopt a pneumatic clamp or an electric clamp.

[0078] In one embodiment, if Figure 3 and Figure 10-11As shown, the reagent filling device 500 includes multiple liquid storage tanks 510, multiple injection needles 520, and multiple infusion tubes (not shown) that connect the multiple liquid storage tanks 510 and the multiple injection needles 520 one by one, and the multiple injection needles 520 correspond to each other on the extraction cartridge. Multiple chambers for accommodating different reagents are respectively extracted one by one, and liquid is transported by pressure difference or pump between the liquid storage tank 510 and the injection needle 520. In the present embodiment, the reagent filling device 500 is provided with multiple peristaltic pumps 530, which are used to provide power for the liquid in the multiple infusion tubes respectively. By designing as above, it is possible to realize that the corresponding reagents are respectively filled into multiple chambers at one time, thereby improving the filling efficiency. Moreover, by automatically filling the reagents with the reagent filling device 500, the filling amount of each reagent can be accurately controlled. Since there is no manual participation in manual filling, impurities such as dust will not be introduced during the filling process, thereby ensuring the cleanliness of the reagents, and then improving the product qualification rate.

[0079] Multiple liquid storage tanks 510 are used to hold different reagents respectively. Taking the extraction card box used for nucleic acid testing as an example, the reagents include lysate, extraction solution, magnetic bead mixture, pure water, eluent, etc.). In addition, in order to prevent precipitation of special filling liquids (such as magnetic bead mixtures), the corresponding liquid storage tanks 510 are also provided with a stirring mechanism 540, and the stirring mechanism 540 includes a stirring paddle inserted into the liquid storage tank 510 and a stirring motor located outside the liquid storage tank 510 and used to drive the stirring paddle to rotate. As the reagents are continuously consumed, it is necessary to replenish the solution in the liquid storage tank 510. In the prior art, the operator usually judges the liquid level in the liquid storage tank 510 and performs a liquid replenishment operation. In the embodiment of the present application, a liquid level sensor is respectively provided in each liquid storage tank 510 to monitor the liquid level in real time, and an alarm is issued to prompt the operator to replenish the reagent when the liquid level is lower than the set value.

[0080] In a specific embodiment, Figure 10-11 As shown, the reagent filling device 500 further includes a mounting plate 550 and a lifting drive 560 for driving the mounting plate 550 to move up and down to approach or move away from the reagent filling station 50 , and a plurality of injection needles 520 are mounted on the mounting plate 550 .

[0081] Through the above arrangement, when filling reagents, the lifting drive 560 is used to drive multiple injection needles 520 to descend, reducing the distance between each injection needle 520 and the extraction card box during filling, thereby avoiding problems such as reagent splashing and significantly improving the stability of liquid injection.

[0082] Specifically, the lifting actuator 560 may adopt a linear drive mechanism 112 such as a linear cylinder or an electric cylinder.

[0083] In one embodiment, if Figure 3-Figure 4 and Fig.12As shown, the extraction card box filling and sealing equipment also includes a material unloading and handling device 700 and a material unloading conveyor 800. The material unloading and handling device 700 is arranged near the unloading station, and one end of the material unloading conveyor 800 is connected to the material unloading and handling device 700, wherein the material unloading and handling device 700 includes a clamp 720 and a rotating lifting mechanism 710 connected to the clamp 720 to drive the clamp 720 to rotate and lift. The clamp 720 can be a pneumatic clamp. Under the action of the rotating lifting mechanism 710, the clamp moves the extraction card box that has been filled and sealed from the carrier 120 to the material unloading conveyor 800, and transports it to the collection box through the material unloading conveyor 800. The material unloading conveyor 800 can specifically be a conveyor belt. It should be noted that in other implementations, the material unloading and handling device 700 can also use a small mechanical arm.

[0084] The utility model also provides a method for using the extraction card box filling and sealing device as described above, combined with Figure 3 and Figure 4 As shown, the method of use includes the following steps:

[0085] S1. Position the extraction cartridge bottom upward on the carrier 120 on the loading station 10;

[0086] S2. The extraction cartridge is switched to the first film sealing station 30 under the action of the station switching device 100, and the first film sealing device 300 seals the bottom of the extraction cartridge;

[0087] S3. The extraction cartridge is switched to the flip station 40 under the action of the station switching device 100, and the flip station 40 flips the extraction cartridge so that its top faces upward;

[0088] S4. The extraction cartridge is switched to the reagent filling station 50 under the action of the station switching device 100, and the reagent filling device 500 fills the reagent in the extraction cartridge;

[0089] S5. The extraction cartridge is switched to the second film sealing station 60 under the action of the station switching device 100, and the second film sealing device 600 seals the top of the extraction cartridge;

[0090] S6. The extraction card box is switched to the sample unloading station 70 for unloading under the action of the station switching device 100.

[0091] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0092] The above embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the attached claims.

Claims

1. An extraction cartridge filling and sealing device, characterized in that: include: The station switching device (100) comprises a conveying mechanism (110) and a plurality of carriers (120) arranged on the conveying mechanism (110) for positioning extraction cartridges, wherein the plurality of carriers (120) can sequentially pass through a sample loading station (10), a first film sealing station (30), a flipping station (40), a reagent filling station (50), a second film sealing station (60) and a sample unloading station (70) under the action of the conveying mechanism (110); On the sample loading station (10), the extraction cartridge is positioned on the carrier (120) with its bottom facing upwards; A first film sealing device (300) used for sealing the bottom of the extraction cartridge located at the first film sealing station (30); a flipping device (400) for flipping the extraction card box on the flipping station (40) so that the top of the extraction card box is positioned upward on the carrier (120); A reagent filling device (500) for filling the extraction cartridge located at the reagent filling station (50) with reagent; as well as The second film sealing device (600) is used to seal the top of the extraction cartridge located on the second film sealing station (60).

2. The extraction cartridge filling and sealing device according to claim 1, characterized in that: The conveying mechanism (110) comprises a turntable (111) and a driving mechanism (112) for driving the turntable (111) to rotate, and a plurality of carriers (120) are evenly arranged on the turntable (111) along the circumferential direction.

3. The extraction cartridge filling and sealing device according to claim 1, characterized in that: The carrier (120) comprises a bottom plate (121), a top plate (122), a guide column (123), an elastic member (124) and a seat body (125); the guide column (123) passes through the conveying mechanism (110) from top to bottom; the top plate (122) and the bottom plate (121) are respectively arranged at the upper and lower ends of the guide column (123); the elastic member (124) is arranged between the top plate (122) and the conveying mechanism (110); the seat body (125) is arranged on the top plate (122); and a positioning groove (1251) for positioning the extraction cartridge is arranged on the top of the seat body (125).

4. The extraction cartridge filling and sealing device according to claim 1, characterized in that: The extraction cartridge filling and sealing device further comprises a detection device (200), and a detection station (20) is further provided between the sample loading station (10) and the first sealing station (30), and the detection device (200) is used to detect whether an extraction cartridge is present on the carrier (120) located on the detection station (20).

5. The extraction cartridge filling and sealing device according to claim 1, characterized in that: The first film sealing device (300) comprises a film unwinding mechanism (320), a reeling mechanism (330), and a punching mechanism (340) and a heat sealing mechanism (350) arranged between the film unwinding mechanism (320) and the reeling mechanism (330), wherein the film unwinding mechanism (320) releases the aluminum foil film by rotating the aluminum foil roll, the punching mechanism (340) is used to cut a packaging film that is compatible with the extraction card box at breakpoints on the aluminum foil film, the heat sealing mechanism (350) is used to heat-press weld the packaging film from the aluminum foil film to the extraction card box, and the reeling mechanism (330) is used to pull and roll up the waste film.

6. The extraction cartridge filling and sealing device according to claim 5, characterized in that: The punching mechanism (340) comprises a lower template (341), a punching drive member (342) and an upper template (343); the punching drive member (342) is arranged above the lower template (341); the upper template (343) is arranged on the punching drive member (342); and the upper template (343) can approach or move away from the lower template (341) under the drive of the punching drive member (342); knives for cutting aluminum foil are arranged on the opposite inner sides of the upper template (343) and the lower template (341); and the aluminum foil released by the film releasing mechanism (320) passes between the upper template (343) and the lower template (341); and / or, The heat sealing mechanism (350) comprises a material pressing plate (351), a material receiving plate (352), a heat sealing block (353), and a heat pressing lifting module (354). The material pressing plate (351) and the material receiving plate (352) are arranged above the first film sealing station (30) with a gap therebetween for allowing the aluminum foil film to pass through. The material pressing plate (351) and the material receiving plate (352) are both provided with An avoidance hole adapted to the shape of the packaging film is provided, the hot pressure lifting module (354) is arranged above the pressing plate (351), the heat sealing block (353) is arranged at the movable end of the hot pressure lifting module (354), and a heating element is provided in the heat sealing block (353). The heat sealing block (353) can move up and down under the drive of the hot pressure lifting module (354) to punch the packaging film out of the avoidance hole and weld it to the extraction box.

7. The extraction cartridge filling and sealing device according to claim 5 or 6, characterized in that: The second film sealing device (600) has the same structure as the first film sealing device (300).

8. The extraction cartridge filling and sealing device according to claim 1, characterized in that: The flipping device (400) comprises a lifting mechanism (410), a rotating mechanism (420) arranged on the lifting mechanism (410), and a clamping mechanism (430) arranged on the rotating mechanism (420); the clamping mechanism (430) is capable of moving up and down under the action of the lifting mechanism (410) and flipping up and down under the action of the rotating mechanism (420).

9. The extraction cartridge filling and sealing device according to claim 1, characterized in that: The reagent filling device (500) comprises a plurality of liquid storage tanks (510), a plurality of injection needles (520), and a plurality of infusion tubes that connect the plurality of liquid storage tanks (510) and the plurality of injection needles (520) in a one-to-one correspondence, and liquid is transported between the liquid storage tanks (510) and the injection needles (520) via a pressure difference or a pump.

10. The extraction cartridge filling and sealing device according to claim 9, characterized in that: The reagent filling device (500) further comprises a mounting plate (550) and a lifting drive (560) for driving the mounting plate (550) to move up and down to approach or move away from the reagent filling station (50), and a plurality of injection needles (520) are mounted on the mounting plate (550).

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