Chip detection card

Abstract

The utility model discloses a chip detection card which comprises a substrate, a diluent plate, an electrode and a locking assembly, the locking assembly comprises a first locking piece and a second locking piece, and in a locking state, the first locking piece is connected with the locking pieces in a locking mode so as to achieve combination and fixation of the substrate and the diluent plate; in the unlocking state, the first locking piece and the second locking piece are separated and unlocked, so that the base plate and the diluent plate are separated and disassembled. Due to the fact that the substrate and the diluent plate are detachably connected, a disposable chip can be installed between the substrate and the diluent plate for use, and blockage caused by repeated use of the chip and cross contamination between samples can be avoided; moreover, the substrate and the diluent plate are detachably connected through the locking assembly, the substrate and the diluent plate can be rapidly locked and separated through the locking assembly, the substrate and the diluent plate are easy and convenient to disassemble and assemble, and a chip installed between the substrate and the diluent plate is not prone to being damaged.

Description

Technical Field

[0001] The utility model relates to the technical field of analysis and detection, in particular to a chip detection card. Background Art

[0002] At present, in many fields such as biomedical analysis, biochemical research, food and drug safety, there is a demand for sampling analysis and rapid detection. The basic principle of the existing test card used for nanoparticle detection is the nanoscale Coulter principle. The micropores of the chip used in the traditional Coulter principle test card are repeatedly used, which is easy to cause blockage and difficult to clean, resulting in easy cross-contamination between samples. In order to solve this problem, a detachable test card is currently used to replace a disposable chip, thereby avoiding blockage of the chip micropores and cross-infection between samples.

[0003] However, the current method of disassembling and installing the chip detection card is: after placing the chip in the square slot on the main card, the secondary card is covered and fastened by screwing two fixing screws on the detection card. This installation method is complicated, time-consuming and labor-intensive, and may also cause the chip to break, thereby causing huge losses. Utility Model Content

[0004] The utility model provides a chip detection card, which is used to solve the problem that the disassembly and assembly of the chip detection card is complicated, time-consuming and labor-intensive, and easily causes chip breakage.

[0005] In one embodiment, a chip detection card is provided, comprising:

[0006] A substrate having a sample liquid tank, a chip tank and a first docking surface, wherein the chip tank is located on the first docking surface and communicates with the sample liquid tank, and the chip tank is used to install a chip;

[0007] The diluent plate comprises a diluent tank and a second docking surface, wherein the diluent tank extends to the second docking surface; when the second docking surface is docked with the first docking surface, the diluent tank is connected with the chip tank;

[0008] The electrodes include a first electrode and a second electrode, wherein the first electrode is disposed on the substrate, one end of the first electrode extends into the sample tank, and the other end of the first electrode is used to connect to a nano-Coulter detector, and the second electrode is disposed on the diluent plate, one end of the second electrode extends into the diluent tank, and the other end of the second electrode is used to connect to a nano-Coulter detector; and

[0009] A locking assembly, comprising a first locking member and a second locking member, wherein the first locking member is disposed on the base plate, and the second locking member is disposed on the diluent plate;

[0010] Wherein, the first locking member and the second locking member have a locked state and an unlocked state. In the locked state, the first docking surface contacts the second docking surface, and the first locking member is locked and connected with the locking member to realize the combined fixation of the substrate and the diluent plate; in the unlocked state, the first locking member and the second locking member are separated and unlocked to realize the separation and splitting of the substrate and the diluent plate.

[0011] In one embodiment, the first docking surface is provided with a first mounting groove, and the first locking member is movably arranged in the first mounting groove; the second docking surface is provided with a second mounting groove, and the second locking member is arranged in the second mounting groove; in the locked state, the first locking member moves into the second mounting groove and is locked and connected to the second locking member; in the unlocked state, the first locking member moves into the second mounting groove and is separated and unlocked from the second locking member.

[0012] In one embodiment, the locking assembly also includes a first elastic member and an unlocking member arranged in the first mounting groove, the first elastic member is connected to the first locking member, and the first elastic member is used to drive the first locking member to move until it is locked and connected with the second locking member; one end of the unlocking member is exposed from the first mounting groove, and the other end of the unlocking member is connected to the first locking member, and the unlocking member is used to drive the first locking member to move until it is separated and unlocked from the second locking member.

[0013] In one embodiment, an opening communicating with the first mounting groove is provided on the top surface or the side surface of the substrate, and one end of the unlocking member is exposed from the opening.

[0014] In one embodiment, the locking assembly also includes an operating member disposed in the first mounting groove, one end of the operating member is exposed from the first mounting groove, and the other end of the operating member is connected to the first locking member, and the operating member is used to drive the first locking member to move until it is locked and connected to the second locking member, and to drive the first locking member to move until it is separated and unlocked from the second locking member.

[0015] In one embodiment, one end of the first locking member exposes the first installation slot, the exposed end of the locking member is provided with a hook, and the second locking member is provided with a slot; in the locked state, the hook is connected to the slot, and in the unlocked state, the hook is separated from the slot; and / or, the second locking member and the diluent plate are an integrated structure.

[0016] In one embodiment, an inclined guide surface is provided on the surface of the hook facing away from the first installation slot, and the second locking member can squeeze the guide surface to drive the first locking member to rotate, thereby achieving connection between the hook and the slot.

[0017] In one embodiment, the first docking surface is provided with two first mounting grooves, the two first mounting grooves are located on both sides of the chip groove, and the first locking piece is provided in each first mounting groove; the second docking surface is provided with two second mounting grooves corresponding to the first mounting groove, and the second locking piece is provided in each second mounting groove.

[0018] In one embodiment, the first locking members in the two first installation grooves rotate in opposite directions when locked, and rotate in opposite directions when unlocked.

[0019] In one embodiment, it also includes a pop-up component, the first docking surface and / or the second docking surface is provided with a third mounting groove, the pop-up component includes a second elastic member and a push rod, the second elastic member and the push rod are arranged in the third mounting groove, the second elastic member is connected to the push rod, and the second elastic member always provides the push rod with an elastic force to drive the push rod to move out of the third mounting groove; in the locked state, the push rod is squeezed into the third mounting groove by the first docking surface or the second docking surface; in the unlocked state, the push rod exposes the third mounting groove and drives the substrate to separate from the diluent plate.

[0020] In one embodiment, the base plate is provided with an L-shaped step groove, the side surface of the step groove is the first docking surface, and the diluent plate is detachably installed in the step groove.

[0021] In one embodiment, a first guide member perpendicular to the first docking surface is provided on the bottom surface of the step groove, and a second guide member is provided on the bottom surface of the diluent plate. The first guide member and the second guide member are slidably connected to limit the diluent plate to achieve docking and separation along a direction perpendicular to the first docking surface.

[0022] In one embodiment, the chip slot is a circular positioning slot, and the circular positioning slot is used to position and install the chip.

[0023] According to the chip detection card of the above embodiment, since the substrate and the diluent plate are detachably connected, a disposable chip can be installed between the substrate and the diluent plate for use, which can avoid clogging caused by repeated use of the chip and cross contamination between samples; and the substrate and the diluent plate are detachably connected by a locking assembly, and the locking assembly can realize rapid locking and separation of the substrate and the diluent plate, so that the disassembly and assembly of the substrate and the diluent plate is simple and convenient, and the chip installed between the substrate and the diluent plate is not easily damaged. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a schematic diagram of the structure of a chip detection card in an embodiment;

[0025] Figure 2 is a schematic structural diagram of a substrate in an embodiment;

[0026] Figure 3 A schematic diagram of the structure of a diluent plate in an embodiment;

[0027] Figure 4 is a cross-sectional view of a diluent plate in one embodiment;

[0028] Figure 5 A schematic diagram of the structure of the disassembly and assembly direction of the substrate and the dilution liquid plate in one embodiment;

[0029] Figure 6 A partial structural schematic diagram of a locking assembly in an embodiment;

[0030] Figure 7 A partial structural schematic diagram of a locking assembly in an embodiment;

[0031] Figure 8 A partial structural schematic diagram of a locking assembly in an embodiment;

[0032] The reference numerals are as follows:

[0033] 1-substrate, 11-sample liquid tank, 12-step groove, 121-first guide member, 13-first docking surface, 14-chip slot, 15-first mounting hole, 16-first mounting slot, 161-first limiting portion, 17-opening;

[0034] 2- diluent plate, 21- diluent tank, 22- second docking surface, 23- second mounting hole, 24- second mounting slot, 25- third mounting slot, 26- second guide member;

[0035] 3-electrode, 31-first electrode, 32-second electrode;

[0036] 4-locking assembly, 41-first locking member, 411-second limiting portion, 412-hook, 413-guide surface, 42-second locking member, 421-slot, 43-first elastic member, 44-unlocking member, 45-rotating shaft;

[0037] 5- Chip;

[0038] 6-pop-up assembly, 61-second elastic member, 62-top rod. DETAILED DESCRIPTION

[0039] The present invention is further described in detail below by specific embodiments in conjunction with the accompanying drawings. Wherein similar elements in different embodiments adopt associated similar element numbers. In the following embodiments, many detailed descriptions are intended to enable the present application to be better understood. However, those skilled in the art can easily recognize that some of the features can be omitted in different situations, or can be replaced by other elements, materials, and methods. In some cases, some operations related to the present application are not shown or described in the specification, in order to avoid the core part of the present application being overwhelmed by too much description, and for those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations based on the description in the specification and the general technical knowledge in the art.

[0040] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be interchanged or adjusted in a manner that is obvious to those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for the purpose of clearly describing a certain embodiment and are not meant to be a required sequence, unless otherwise specified that a certain sequence must be followed.

[0041] The serial numbers of the components in this document, such as "first", "second", etc., are only used to distinguish the objects described and do not have any order or technical meaning. The "connection" and "coupling" mentioned in this application, unless otherwise specified, include direct and indirect connections (couplings).

[0042] In one embodiment, a chip detection card is provided, and the chip detection card is used to install a chip with a nanopore. The chip detection card installed with the chip can be installed in a nano-Coulter detector, and the nanoparticle detection of the sample is realized by using the Coulter principle. The chip detection card is arranged in two detachable parts, and the chip can be replaced by disassembly and installation, and then a disposable chip can be used for nano-Coulter detection, without the need to reuse the chip, which can avoid the blockage of the nanopore after the repeated use of the same chip for detection, and can also avoid cross-contamination between samples caused by the repeated use of the chip. The two parts of the chip detection card are detachably connected by a card-connected locking method, which can realize quick disassembly and assembly, and is convenient for disassembly and assembly, and will not cause damage to the chip detection card and the chip.

[0043] Please refer to Figures 1 to 8 The chip detection card of this embodiment mainly includes a substrate 1, a diluent plate 2, an electrode 3 and a locking assembly 4.

[0044] The substrate 1 is a block structure. The substrate 1 is the main part of the chip detection card. The substrate 1 is mainly used for adding samples and can also be called a sample liquid plate. The substrate 1 includes a top surface, a side surface and a bottom surface. The top surface of the substrate 1 is provided with a sample liquid tank 11, and the sample liquid tank 11 is used to add sample liquid. The side of the substrate 1 is provided with an L-shaped step groove 12. The step groove 12 has a side surface perpendicular to the top surface and a bottom surface parallel to the top surface. The top and side of the step groove 12 are open structures. The structure of the step groove 12 is adapted to the diluent plate 2. The diluent plate 2 can be installed in the step groove 12 to achieve connection with the substrate 1.

[0045] Among them, the side surface inside the step groove 12 is the first docking surface 13 of the substrate 1, and a chip groove 14 is provided on the first docking surface 13. The chip groove 14 is used to install a vertically arranged chip 5. The sample liquid groove 11 extends to communicate with the chip groove 14, so that the sample liquid in the sample liquid groove 11 can pass through the chip 5 in the chip groove 14 to realize nano-Coulter detection.

[0046] In other embodiments, the substrate 1 may also be provided with a U-shaped groove, the opening of the U-shaped groove is located on the side of the substrate 1, and the diluent plate 2 is inserted into the U-shaped groove, so that the diluent plate 2 and the substrate 1 can be detachably connected.

[0047] In this embodiment, the diluent plate 2 is a smaller block structure, and the diluent plate 2 can be installed in the stepped groove 12 as a whole. Of course, part of the diluent plate 2 can also be exposed outside the stepped groove 12.

[0048] The top surface of the diluent plate 2 is provided with a diluent tank 21, and the diluent tank 21 is used to add diluent. The side of the diluent plate 2 facing the substrate 1 is a second docking surface 22, and the second docking surface 22 has a notch connected to the diluent tank 21, and the notch is aligned with the chip slot 14. When the diluent plate 2 is installed on the substrate 1, the notch of the second docking surface 22 is docked and connected with the chip slot 14, and finally the sample liquid tank 11, the chip slot 14 and the diluent tank 21 are connected. After adding sample liquid to the sample liquid tank 11, installing the chip 5 in the chip slot 14 and adding diluent to the diluent tank 21, the concentration of the sample liquid is higher than the diluent, and the sample in the sample liquid will pass through the nanopore of the chip 5 and enter the diluent tank 21, thereby realizing the nano-coulter detection of the sample.

[0049] In this embodiment, the electrode 3 includes a first electrode 31 and a second electrode 32, and the first electrode 31 and the second electrode 32 are respectively a positive electrode and a negative electrode. The substrate 1 is provided with a first mounting hole 15, one end of the first mounting hole 15 is located on the side of the substrate 1, and the side is perpendicular to the first docking surface 13, and the other end of the first mounting hole 15 extends to communicate with the sample liquid tank 11, and the first electrode 31 is detachably plugged into the first mounting hole 15, and one end of the first electrode 31 extends into the sample liquid tank 11 for contacting with the sample liquid, and the other end of the first electrode 31 is exposed in the first mounting hole 15, and the exposed end of the first electrode 31 is used for electrically connecting to the nano-Coulter detector. The diluent plate 2 is provided with a second mounting hole 23, one end of the second mounting hole 23 is located on the side of the diluent plate 1, and the side is perpendicular to the second docking surface 22, and the other end of the second mounting hole 23 extends to communicate with the diluent tank 21, and the second electrode 32 is detachably inserted into the second mounting hole 23, and one end of the second electrode 32 extends into the diluent tank 21 for contacting the diluent, and the other end of the second electrode 32 is exposed from the second mounting hole 23, and the exposed end of the second electrode 32 is used for electrically connecting to the nano-Coulter detector.

[0050] The first electrode 31 and the second electrode 32 are exposed on the same side of the chip detection card, so that the first electrode 31 and the second electrode 32 can be more easily electrically connected to the nano-Coulter detector.

[0051] In other embodiments, the first electrode 31 and the second electrode 32 are exposed on different sides of the chip detection card, and electrical connection terminals are provided at corresponding positions in the nano-Coulter detector, so that the first electrode 31 and the second electrode 32 can be electrically connected to the nano-Coulter detector.

[0052] In this embodiment, the first electrode 31 and the second electrode 32 are both detachably connected, so that the first electrode 31 and the second electrode 32 can be disassembled for cleaning to avoid cross contamination between samples. The first mounting hole 15 and the second mounting hole 23 can be provided with a sealing structure such as an elastic sealing ring, so that the first electrode 31 and the second electrode 32 can be detachable and the first mounting hole 15 and the second mounting hole 23 can be sealed and connected to avoid leakage from the first mounting hole 15 and the second mounting hole 23 during the detection process.

[0053] In other embodiments, the first electrode 31 can be directly fixed in the first mounting hole 15, and the second electrode 32 can also be directly fixed in the second mounting hole 23, so that the chip detection card and the nano-Coulter detector can be electrically connected.

[0054] In this embodiment, the first docking surface 13 of the substrate 1 is provided with a first mounting groove 16, and the second docking surface 22 of the diluent plate 2 is provided with a second mounting groove 24, and the first mounting groove 16 and the second mounting groove 24 are aligned along a direction perpendicular to the first docking surface 13. The first mounting groove 16 can be respectively set in a mounting block, and the mounting block with the first mounting groove 16 is fixedly mounted on the substrate 1 by means of clamping, screw connection, etc., so that it is convenient to assemble the components in the first mounting groove 16; of course, the first mounting groove 16 can also be directly integrated in the substrate 1. The second mounting groove 24 can be directly integrated in the diluent plate 2, or it can be set in a mounting block, and the mounting block with the second mounting groove 24 is fixedly mounted on the diluent plate 2 by means of clamping, screw connection, etc.

[0055] The top surface of the substrate 1 is provided with an opening 17 communicating with the first mounting groove 16 .

[0056] The locking assembly 4 includes a first locking member 41 , a second locking member 42 , a first elastic member 43 and an unlocking member 44 . The first locking member 41 , the first elastic member 43 and the unlocking member 44 are disposed in the first mounting groove 16 , and the second locking member 42 is disposed in the second mounting groove 24 .

[0057] The first locking member 41 may be a rod-shaped structure, and the first locking member 41 may be rotatably installed in the first installation groove 16 via a rotating shaft 45. The rotating shaft 45 connected to the first locking member 41 is parallel to the first docking surface 13, so that the first locking member 41 may rotate in a plane parallel to the top surface. One end of the first locking member 41 is exposed from the first installation groove 16, and a hook 412 is provided at the exposed end of the first locking member 41.

[0058] The first elastic member 43 can be a compression spring, a tension spring or a torsion spring. One end of the first elastic member 43 can be fixed in the first mounting groove 16 by a connecting member such as a fixing block, and the other end of the first elastic member 43 is connected to one end of the first locking member 41 located in the first mounting groove 16. The first elastic member 43 always provides an elastic force to the first locking member 41 to drive the first locking member 41 to rotate until it is locked and connected with the second locking member 42.

[0059] One end of the unlocking member 44 is connected to one end of the first locking member 41 located in the first installation groove 16, and the other end of the unlocking member 44 is exposed from the opening 17. The user can operate the unlocking member 44 to drive the first locking member 41 to rotate and separate from the second locking member 42 to unlock.

[0060] The unlocking member 44 can be an integrated structure with the first locking member 41, and the unlocking member 44 can also be fixedly connected to the first locking member 41 by means of snap connection, screw connection, bonding, etc.

[0061] The upper surface of the unlocking member 44 may be provided with an anti-slip structure, which may be a wave pattern, a convex dot or other structure. The provision of the anti-slip structure may prevent the user from slipping when operating the unlocking member 44, thereby ensuring the accuracy of the operation.

[0062] The first installation groove 16 may be provided with a first limiting portion 161, which may be a limiting block installed in the first installation groove 16. The first locking member 41 may be provided with a second limiting portion 411, which may be a protruding structure of the first locking member 41. The first limiting portion 161 and the first elastic member 43 are located on both sides of the first locking member 41. When the elastic force of the first elastic member 43 drives the first locking member 41, the first limiting portion 161 blocks the movement of the second limiting portion 411, thereby limiting the rotation limit position of the first elastic member 43.

[0063] Of course, the first locking member 41 can also be limited to the extreme position by the spacing between the unlocking member 44 and the edge of the opening 17 .

[0064] The second locking member 42 may be provided with a slot 421 . The second locking member 42 may be an integrated structure with the diluent plate 2 . The second locking member 42 may also be fixed in the second mounting slot 24 by means of a snap connection, a screw connection or the like.

[0065] In this embodiment, the locking assembly 4 has a locking state and an unlocking state; in the locking state, the second docking surface 22 of the diluent plate 2 is docked with the first docking surface 13 of the substrate 1, and the first locking member 41 has an end of the hook 412 inserted into the second mounting groove 24. Driven by the first elastic member 43, the hook 412 of the first locking member 41 rotates to be inserted into the slot 421 of the second locking member 42, forming a locking connection between the first locking member 41 and the second locking member 42. In this state, the substrate 1 and the diluent plate 2 are fixed and cannot be separated; in the unlocking state, the user toggles the unlocking member 44 to drive the first locking member 41 to rotate in the reverse direction, and the hook 412 of the first locking member 41 is separated from the slot 421 of the second locking member 42, forming an unlocking and separation of the first locking member 41 and the second locking member 42. At this time, the substrate 1 and the diluent plate 2 are in a separated state, and the diluent plate 2 can be detached from the substrate 1.

[0066] Wherein, a first elastic member 43 is provided, and after the base plate 1 and the diluent plate 2 are docked, a locking connection can be automatically achieved, which can greatly improve the operational convenience of docking and locking the base plate 1 and the diluent plate 2.

[0067] In the chip detection card of the present embodiment, since the substrate 1 and the diluent plate 2 are detachably connected, a disposable chip 5 can be installed between the substrate 1 and the diluent plate 2 for use, which can avoid clogging caused by repeated use of the chip 5 and cross contamination between samples; and the substrate 1 and the diluent plate 2 are detachably connected through the locking component 4, and the locking component 4 can realize rapid locking and separation of the substrate 1 and the diluent plate 2, and the disassembly and assembly of the substrate 1 and the diluent plate 2 is simple and convenient, and it is not easy to damage the chip 5 installed between the substrate 1 and the diluent plate 2.

[0068] In one embodiment, the locking assembly 4 includes a first locking member 41, a second locking member 42 and an operating member. The structure and installation method of the first locking member 41 and the second locking member 42 are the same as those in the above embodiment.

[0069] The first locking member 41 and the rotating shaft 45 are connected in a damped rotational connection, that is, the first locking member 41 cannot rotate without external driving force. The operating member has a similar structure to the unlocking member 44, one end of the operating member is connected to one end of the first locking member 41 located in the first installation groove 16, and the other end of the operating member is exposed in the opening 17. The user can operate the operating member to drive the first locking member 41 to rotate to lock and connect with the second locking member 42, and the user can also operate the operating member to drive the first locking member 41 to rotate in the opposite direction to separate and unlock from the second locking member 42.

[0070] The user can lock and separate the base plate 1 and the diluent plate 2 through the operating member. The locking and separation are both manually operated and the operation is relatively simple.

[0071] In one embodiment, the locking assembly 4 includes a first locking member 41 and a second locking member 42, and the first locking member 41 and the second locking member 42 are two magnetic blocks with different magnetic properties, or one of the first locking member 41 and the second locking member 42 is a magnetic block and the other is a magnetizable metal block.

[0072] Sufficient magnetic attraction is provided between the first locking member 41 and the second locking member 42. When the substrate 1 and the diluent plate 2 need to be assembled, the substrate 1 and the diluent plate 2 can be fixed by the magnetic attraction formed between the first locking member 41 and the second locking member 42 after the substrate 1 and the diluent plate 2 are close to each other; when the substrate 1 and the diluent plate 2 need to be separated, the user can apply a certain pulling force to separate the substrate 1 and the diluent plate 2.

[0073] The first locking member 41 and the second locking member 42 which are magnetically attracted can also realize the rapid disassembly and assembly of the base plate 1 and the diluent plate 2 .

[0074] Please refer to Figures 1 to 4In one embodiment, the end of the first locking member 41 exposed from the first mounting groove 16 is a hook 412, and the surface of the hook 412 facing away from the first mounting groove 16 is provided with an inclined guide surface 413. When the base plate 1 and the diluent plate 2 are assembled, the second locking member 42 will squeeze the guide surface 413 to drive the first locking member 41 to rotate, that is, drive the hook 412 to rotate, so that the hook 412 can slide into the slot 421 of the second locking member 42, thereby realizing the locking connection between the base plate 1 and the diluent plate 2.

[0075] In other embodiments, a corresponding inclined guide surface is provided on the surface of the second locking member 42 facing the first docking surface 13. When the base plate 1 is assembled with the diluent plate 2, the guide surface 413 of the second locking member 42 squeezes and drives the first locking member 41 to rotate, that is, drives the hook 412 to rotate, and also allows the hook 412 to slide into the slot 421 of the second locking member 42, thereby achieving a locked connection between the base plate 1 and the diluent plate 2.

[0076] Please refer to Figures 1 to 5 In one embodiment, the chip slot 14 is located in the middle of the first docking surface 13, and the first docking surface 13 is provided with two first mounting grooves 16, and the two first mounting grooves 16 are symmetrically arranged on both sides of the chip slot 14, and each first mounting groove 16 is installed with a first locking member 41, a first elastic member 43 and an unlocking member 44; correspondingly, the top surface of the substrate 1 is provided with two openings 17, and the two openings 17 are connected to the two first mounting grooves 16 one by one.

[0077] The second docking surface 22 of the diluent plate 2 is provided with two second mounting grooves 24, each second mounting groove 24 is provided with a second locking member 42, the two first mounting grooves 16 and the two second mounting grooves 24 are provided in a one-to-one correspondence, and accordingly, two sets of locking components 4 are provided. The two sets of locking components 4 simultaneously lock the substrate 1 and the diluent plate 2 on both sides of the chip slot 14, so that the substrate 1 and the diluent plate 2 are evenly stressed, and the chip 5 in the chip slot 14 is not easily damaged, and the firmness of the locking can also be improved.

[0078] The two sets of locking components 4 can be symmetrically arranged, that is, the two first locking members 41 rotate in opposite directions when locked and rotate in opposite directions when unlocked. This allows the user to simultaneously operate the two unlocking members 44 with one hand and move them closer to each other along direction A, thereby simultaneously unlocking the two sets of locking components 4. With this arrangement, it is easier for the user's fingers to achieve force control, and it is convenient for the user to operate the two unlocking members 44.

[0079] In other embodiments, a first mounting groove 16 and a second mounting groove 24 are provided, and a set of locking components 4 are installed correspondingly, so that the base plate 1 and the diluent plate 2 can also be detachably connected.

[0080] Please refer to Figures 3 to 5In one embodiment, the chip detection card further includes an ejection assembly 6 , and the ejection assembly 6 includes a second elastic member 61 and a push rod 62 .

[0081] The second docking surface 22 of the diluent plate 2 is provided with a third mounting groove 25, and the second elastic member 61 and the push rod 62 are installed in the third mounting groove 25. The second elastic member 61 can be a compression spring, and the second elastic member 61 is installed at the bottom of the third mounting groove 25. One end of the push rod 62 is connected to the second elastic member 61, and the second elastic member 61 always provides an elastic force to the push rod 62 to drive the push rod 62 to extend out of the third mounting groove 25.

[0082] When the base plate 1 and the diluent plate 2 are not connected, the end of the push rod 62 away from the second elastic member 61 will be driven by the second elastic member 61 to extend out of the third installation groove 25 .

[0083] The setting of the pop-up component 6 is such that when the unlocking member 44 is used to manually operate the first locking member 41 and the second locking member 42 to separate, under the action of the second elastic member 61, the end of the push rod 62 away from the second elastic member 61 extends out and presses on the first docking surface 13, thereby driving the dilution liquid plate 2 away from the substrate 1 along the B direction, realizing the separation movement from the substrate 1, which is convenient for users to separate the substrate 1 and the dilution liquid plate 2.

[0084] During locking, after the base plate 1 and the diluent plate 2 are docked, the end of the push rod 62 away from the second elastic member 61 will be squeezed back into the third mounting groove 25 by the first docking surface 13, and the push rod 62 does not affect the docking and locking of the base plate 1 and the diluent plate 2.

[0085] Among them, the second docking surface 22 can be provided with two third mounting grooves 25, each third mounting groove 25 is installed with a group of pop-up components 6, and the two third mounting grooves 25 are located on both sides of the dilution liquid groove 21, so that the two groups of pop-up components 6 can provide a more uniform pop-up force for the separation of the dilution liquid plate 2 and the substrate 1, thereby avoiding tilting when the substrate 1 is separated from the dilution liquid plate 2.

[0086] In other embodiments, the third mounting groove 25 is disposed on the first docking surface 13 of the substrate 1, and the pop-up assembly 6 is disposed in the third mounting groove 25 on the substrate 1, which can also drive the substrate 1 and the dilution liquid plate 2 to separate, thereby facilitating the disassembly of the substrate 1 and the dilution liquid plate 2.

[0087] In other embodiments, the first docking surface 13 and the second docking surface 22 are respectively provided with a third mounting groove 25, and the third mounting grooves 25 provided on the two are staggered, and an ejection assembly 6 is installed in each third mounting groove 25. In this way, multiple groups of ejection assemblies 6 are formed to simultaneously drive the substrate 1 to separate from the diluent plate 2, thereby preventing the substrate 1 from tilting when the diluent plate 2 is separated.

[0088] Please refer to Figures 1 to 3In one embodiment, the bottom surface of the step groove 12 is provided with a first guide member 121 perpendicular to the first docking surface 13, and the bottom surface of the diluent plate 2 is provided with a second guide member 26. The first guide member 121 can be a convex strip protruding from the bottom surface of the step groove 12, and the second guide member 26 can be a strip groove, and the boss is adapted to the strip groove.

[0089] When the base plate 1 and the diluent plate 2 are assembled or disassembled, the diluent plate 2 can slide along a direction perpendicular to the first docking surface 13 under the guidance of the first guide member 121 and the second guide member 26 to achieve docking or separation.

[0090] The guiding function of the first guide member 121 and the second guide member 26 can achieve accurate docking of the notch of the dilution liquid groove 21 of the dilution liquid plate 2 with the chip groove 14 of the substrate 1, thereby avoiding partial obstruction of the chip 5 and leakage caused by incorrect docking between the substrate 1 and the dilution liquid plate 2.

[0091] Among them, the second guide member 26 can include multiple parallel convex strips, and the second guide member 26 can include multiple strip grooves with corresponding numbers and spacings. The multiple convex strips and the multiple strip grooves are connected one by one, which can improve the stability of the guiding docking between the substrate 1 and the dilution liquid plate 2.

[0092] In other embodiments, the first guide member 121 is configured as a strip groove, and the second guide member 26 is configured as a convex strip, which can also achieve the guided docking between the substrate 1 and the diluent plate 2 .

[0093] Please refer to Figure 2 In one embodiment, the chip slot 14 is a circular positioning slot, and the diameter of the circular positioning slot is equal to the length of the diagonal of the square chip 5, so that the four corners of the square chip 5 abut against the inner wall of the circular positioning slot to achieve the positioning and installation of the chip 5.

[0094] The chip slot 14 realizes positioning and installation of the chip 5, which can ensure the stability and accuracy of the installation of the chip 5 and prevent the chip 5 from moving during the detection process.

[0095] In other embodiments, the inner diameter of the chip slot 14 may also be larger than the length of the diagonal of the square chip 5 . Four clamping parts are provided in the chip slot 14 . The four clamping parts correspond to the four corners of the clamping chip 5 , and the positioning and installation of the chip 5 can also be achieved.

[0096] The above specific examples are used to illustrate the present invention, which are only used to help understand the present invention and are not intended to limit the present invention. For those skilled in the art of the present invention, some simple deductions, deformations or substitutions can be made based on the idea of ​​the present invention.

Claims

1. A chip detection card, characterized in that: include: A substrate having a sample liquid tank, a chip tank and a first docking surface, wherein the chip tank is located on the first docking surface and communicates with the sample liquid tank, and the chip tank is used to install a chip; The diluent plate comprises a diluent tank and a second docking surface, wherein the diluent tank extends to the second docking surface; when the second docking surface is docked with the first docking surface, the diluent tank is connected with the chip tank; The electrodes include a first electrode and a second electrode, wherein the first electrode is disposed on the substrate, one end of the first electrode extends into the sample tank, and the other end of the first electrode is used to connect to a nano-Coulter detector, and the second electrode is disposed on the diluent plate, one end of the second electrode extends into the diluent tank, and the other end of the second electrode is used to connect to a nano-Coulter detector; and A locking assembly, comprising a first locking member and a second locking member, wherein the first locking member is disposed on the base plate, and the second locking member is disposed on the diluent plate; Wherein, the first locking member and the second locking member have a locked state and an unlocked state. In the locked state, the first docking surface contacts the second docking surface, and the first locking member is locked and connected with the locking member to realize the combined fixation of the substrate and the diluent plate; in the unlocked state, the first locking member and the second locking member are separated and unlocked to realize the separation and splitting of the substrate and the diluent plate.

2. The chip detection card according to claim 1, characterized in that: The first docking surface is provided with a first mounting groove, and the first locking member is movably arranged in the first mounting groove; the second docking surface is provided with a second mounting groove, and the second locking member is arranged in the second mounting groove; in the locked state, the first locking member moves into the second mounting groove and is locked and connected to the second locking member; in the unlocked state, the first locking member moves into the second mounting groove and is separated and unlocked from the second locking member.

3. The chip detection card according to claim 2, characterized in that: The locking assembly also includes a first elastic member and an unlocking member arranged in the first mounting groove, the first elastic member is connected to the first locking member, and the first elastic member is used to drive the first locking member to move until it is locked and connected with the second locking member; one end of the unlocking member is exposed from the first mounting groove, and the other end of the unlocking member is connected to the first locking member, and the unlocking member is used to drive the first locking member to move until it is separated from the second locking member and unlocked.

4. The chip detection card according to claim 3, characterized in that: An opening communicating with the first mounting groove is provided on the top surface or the side surface of the substrate, and one end of the unlocking member is exposed from the opening.

5. The chip detection card as claimed in claim 2, characterized in that: The locking assembly also includes an operating member arranged in the first mounting groove, one end of the operating member is exposed from the first mounting groove, and the other end of the operating member is connected to the first locking member, and the operating member is used to drive the first locking member to move until it is locked and connected with the second locking member, and to drive the first locking member to move until it is separated and unlocked from the second locking member.

6. The chip detection card according to claim 2, characterized in that: One end of the first locking member exposes the first installation slot, the exposed end of the locking member is provided with a hook, and the second locking member is provided with a slot; in the locked state, the hook is connected to the slot, and in the unlocked state, the hook is separated from the slot; and / or, the second locking member and the diluent plate are an integrated structure.

7. The chip detection card according to claim 6, characterized in that: The surface of the hook facing away from the first installation slot is provided with an inclined guide surface, and the second locking member can squeeze the guide surface to drive the first locking member to rotate, thereby achieving the connection between the hook and the slot.

8. The chip detection card according to claim 2, characterized in that: The first docking surface is provided with two first mounting grooves, the two first mounting grooves are located on both sides of the chip groove, and the first locking piece is provided in each first mounting groove; the second docking surface is provided with two second mounting grooves corresponding to the first mounting groove, and the second locking piece is provided in each second mounting groove.

9. The chip detection card according to claim 8, characterized in that: The first locking members in the two first installation grooves rotate in opposite directions when locked, and rotate in opposite directions when unlocked.

10. The chip detection card according to claim 1, characterized in that: It also includes a pop-up component, the first docking surface and / or the second docking surface is provided with a third mounting groove, the pop-up component includes a second elastic member and a push rod, the second elastic member and the push rod are arranged in the third mounting groove, the second elastic member is connected to the push rod, and the second elastic member always provides the push rod with an elastic force to drive the push rod to move out of the third mounting groove; in the locked state, the push rod is squeezed into the third mounting groove by the first docking surface or the second docking surface; in the unlocked state, the push rod exposes the third mounting groove and drives the base plate to separate from the diluent plate.

11. The chip detection card according to claim 1, characterized in that: The base plate is provided with an L-shaped step groove, the side surface of the step groove is the first docking surface, and the diluent plate is detachably installed in the step groove.

12. The chip detection card according to claim 11, characterized in that: A first guide member perpendicular to the first docking surface is provided on the bottom surface of the step groove, and a second guide member is provided on the bottom surface of the diluent plate. The first guide member and the second guide member are slidably connected to limit the diluent plate to achieve docking and separation along a direction perpendicular to the first docking surface.

13. The chip detection card according to claim 1, characterized in that: The chip slot is a circular positioning slot, and the circular positioning slot is used to position and install the chip.

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