Blending device for magnetic particle chemiluminescence kit

Abstract

The utility model discloses a uniform mixing device for a magnetic particle chemiluminescence kit, which comprises a uniform mixing box provided with a working cavity with an upper opening; the oscillation motor is arranged at the bottom of the working cavity, a motor shaft of the oscillation motor is vertically upward, and a horizontal turntable is arranged at the upper end of the oscillation motor and is eccentrically connected with the motor shaft; the oscillation platform is horizontally arranged at the opening of the working cavity, the bottom of the oscillation platform is provided with a transmission sleeve arranged on the outer side of the horizontal rotating disc in a sleeving mode, and traction springs are evenly distributed on the outer wall of the transmission sleeve; the clamping unit is composed of a pair of clamping springs, and a clamping part is formed between the two clamping springs; and the stirring unit is composed of a rotating seat arranged between the two clamping springs and a driving motor. The device has the advantages that the device can be adapted to clamp magnetic particle chemiluminescence kits with various sizes to easily realize uniform mixing oscillation, and uniform force and consistent time of each uniform mixing operation are ensured; and the magnetic bead bottle can be easily rotated under the condition that a cover is not opened, so that the magnetic beads are dispersed, and the accuracy of a detection result is ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of experimental equipment, in particular to a magnetic particle chemiluminescence reagent box mixing device. Background Art

[0002] Currently, immunoassay analysis has entered the era of fully automated magnetic particle chemiluminescence. Figure 6 , 7 The magnetic microparticle chemiluminescence test kit (as shown in the figure) is widely promoted and applied because of its light weight, high degree of automation, and the fact that it can be directly placed in a fully automatic chemiluminescence detector for mixing during use. The magnetic microparticle chemiluminescence test kit contains a magnetic bead bottle mounted on it, and a large number of magnetic microparticles are contained in the magnetic bead bottle. After standing for a period of time, the magnetic microparticles will settle and agglutinate. At this time, if they are directly placed on a fully automatic chemiluminescence detector for immunoassay analysis, it is impossible to ensure that the magnetic microparticles are completely mixed, which in turn has a significant impact on the test results. Currently, the method for dealing with the phenomenon of magnetic microparticle sedimentation and agglutination in magnetic microparticle chemiluminescence test kits is mostly to use a pipette to mix them. This method requires unscrewing the upper cover of the magnetic bead bottle and inserting a pipette, so the operation is relatively complicated and it is easy to contaminate the magnetic bead bottle. In addition, the strength and mixing time of the pipette when mixing are manually completed, and uniformity cannot be guaranteed. This may bring other risks to the reagents, resulting in inaccurate final test results. Summary of the invention

[0003] The utility model aims to provide a mixing device for a magnetic particle chemiluminescence reagent kit.

[0004] In order to achieve the above purpose, the utility model can adopt the following technical solutions:

[0005] The magnetic particle chemiluminescence kit mixing device described in the utility model comprises:

[0006] A mixing box having a working chamber with an upper opening;

[0007] An oscillating motor is arranged at the bottom of the working chamber, the motor shaft of the oscillating motor is vertically upward, and a circular horizontal rotating disk is provided at the upper end thereof, and the horizontal rotating disk is eccentrically connected to the motor shaft;

[0008] An oscillating platform is horizontally arranged at the opening of the working chamber, and the bottom of the oscillating platform has a transmission sleeve sleeved on the outside of the horizontal turntable, and the outer wall of the transmission sleeve is uniformly distributed along the circumference with a pulling spring fixedly connected to the mixing box;

[0009] A clamping unit, which is composed of a pair of clamping springs arranged side by side on the top surface of the oscillating platform, and a clamping portion for clamping the magnetic microparticle chemiluminescence kit is formed between the two clamping springs;

[0010] The stirring unit is composed of a rotating seat arranged between the two clamping springs for clamping the magnetic particle chemiluminescence reagent box, and a driving motor for driving the rotating seat to rotate.

[0011] Specifically, the center of the bottom surface of the rotating seat has a rotating shaft vertically penetrated on the oscillation platform, and the rotating shaft is equipped with a transmission belt connected to the driving shaft of the driving motor. Three groups of stirring blades that are engaged with the magnetic bead bottle of the magnetic microparticle chemiluminescence kit are evenly distributed in a divergent shape at the center of the top surface of the rotating seat.

[0012] Furthermore, in order to improve work efficiency, the clamping units are two groups symmetrically arranged on the top surface of the oscillation platform, and the stirring units are two groups corresponding to the clamping units one by one, so that two groups of magnetic microparticle chemiluminescence kits can be pre-mixed at the same time.

[0013] Furthermore, for the convenience of operation, a control panel should be provided on the front wall of the mixing box, and the control panel has an oscillation rate adjustment knob, a stirring speed adjustment knob and a timing knob.

[0014] The utility model has the advantage that the clamping springs arranged in pairs can not only adapt to clamp magnetic microparticle chemiluminescence kits of various sizes, but also can firmly clamp the magnetic microparticle chemiluminescence kits on the oscillating platform, and then use the oscillation motor to drive the horizontal turntable to drive the transmission sleeve to rotate, so as to easily achieve the mixing and oscillation of the magnetic microparticle chemiluminescence kit on the oscillating platform, ensuring that the force and time of each mixing operation are uniform; in addition, the stirring unit arranged on the oscillating platform can also adapt to the bottom of the magnetic bead bottle in the magnetic microparticle chemiluminescence kit, so as to easily achieve the rotation of the magnetic bead bottle without opening the cover, so that the precipitated and agglomerated magnetic beads can be dispersed, avoiding frequent opening of the cover to cause contamination in the magnetic bead bottle, and ensuring the accuracy of subsequent detection results. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a structural schematic diagram of the utility model.

[0016] Figure 2 yes Figure 1 AA section view.

[0017] Figure 3 yes Figure 1 Top view of the .

[0018] Figure 4 yes Figure 1 Axonometric view of .

[0019] Figure 5 yes Figure 1 Axial enlarged view of the central rotating seat.

[0020] Figure 6 , Figure 7 It is a structural schematic diagram of an existing magnetic particle chemiluminescence kit. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0022] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back...) are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0023] like Figure 1-5 As shown, the magnetic microparticle chemiluminescence kit mixing device described in the utility model includes a mixing box 1, and an oscillating motor 2 and an oscillating platform 3 arranged in the mixing box 1.

[0024] The mixing box 1 is a rectangular box with an upper opening structure. To place the mixing box 1 more stably, silicone suction cups (not shown) that can be fixed on the experimental table surface can be provided at the four corners of the bottom.

[0025] The oscillation motor 2 is fixed at the center of the bottom of the working chamber 4 inside the mixing box 1. The motor shaft 5 of the oscillation motor 2 is vertically upward, and a horizontal turntable 6 with a circular structure is provided at its upper end. The horizontal turntable 6 is eccentrically connected to the motor shaft 5, so that the oscillation motor 2 can drive the horizontal turntable 6 to perform circular motion with the eccentric distance as the radius.

[0026] The oscillation platform 3 is a rectangular structure table, which is horizontally arranged at the opening of the working chamber 4. The bottom of the oscillation platform 3 has a transmission sleeve 7 which is mounted on the outside of the horizontal turntable 6. The transmission sleeve 7 is an inner circle and outer square structure. The diameter of the inner cylindrical cavity of the transmission sleeve 7 is slightly larger than the diameter of the horizontal turntable 6, and four pulling springs 8 fixedly connected to the mixing box 1 are evenly distributed along the circumferential direction on the outer wall of the transmission sleeve 7; the oscillation platform 3 is connected to the horizontal turntable 6 through the transmission sleeve 7, and the oscillation platform 3 is elastically connected to the mixing box 1 through the pulling spring 8, so that when the oscillation motor 2 drives the horizontal turntable 6 to perform a circular motion, the horizontal turntable 6 can push the transmission sleeve 7, and under the gap between the horizontal turntable 6 and the transmission sleeve 7 and the pulling action of the pulling spring 8 on the outside of the transmission sleeve 7, the high-frequency oscillation of the oscillation platform 3 is realized.

[0027] In addition, a clamping unit and a stirring unit are also provided on the oscillating platform 3 .

[0028] The clamping unit is composed of a pair of strip-shaped clamping springs 9 arranged side by side on the top surface of the oscillation platform 3. The distance between the two clamping springs 9 should be smaller than Figure 6 , 7 The width of the magnetic particle chemiluminescent kit 100 shown in the figure forms a clamping portion 10 for clamping the magnetic particle chemiluminescent kit 100. The two clamping springs 9 can not only stably clamp the magnetic particle chemiluminescent kit 100 in the clamping portion 10, but also due to the elasticity of the clamping springs 9 themselves, can also achieve stable clamping of magnetic particle chemiluminescent kits 100 of different widths.

[0029] The stirring unit is composed of a rotating seat 11 disposed between two clamping springs 9 for clamping the magnetic microparticle chemiluminescent reagent kit 100, and a driving motor 12 for driving the rotating seat 11 to rotate. Specifically, the center of the bottom surface of the rotating seat 11 has a rotating shaft 13 vertically penetrated on the oscillating platform 3, and the driving motor 12 is disposed on the bottom surface of the oscillating platform 3. At this time, a transmission belt 15 connected to the driving shaft 14 of the driving motor 12 is mounted on the rotating shaft 13, so that the driving motor 12 and the rotating seat 11 are connected through the transmission belt 15 and the rotating shaft 13, so that the driving motor 12 can easily drive the rotating seat 11 to rotate. At the same time, three groups of stirring blades 16 should be evenly distributed in a divergent shape at the center of the top surface of the rotating seat 11. The three groups of stirring blades 16 match the bottom of the magnetic bead bottle of the magnetic microparticle chemiluminescent reagent kit 100, and can be adapted to be plugged and fixed on the bottom of the magnetic bead bottle, thereby driving the magnetic bead bottle to rotate synchronously with the rotating seat 11. In addition, the rotating shaft 13 is fixed to the oscillating platform 3 through a bearing, and the rotating seat 11 is detachably connected to the upper end of the rotating shaft 13, so as to facilitate the design of various types of rotating seats 11 with stirring blades 16 of different sizes, so that different types of rotating seats 11 can be replaced according to the magnetic bead bottles of the magnetic microparticle chemiluminescence kit 100.

[0030] Furthermore, in order to improve work efficiency, two groups of clamping units can be symmetrically arranged on the top surface of the oscillation platform 3, and two groups of stirring units corresponding to the clamping units can be arranged on the top surface of the oscillation platform 3. Of course, the two groups of stirring units can share a driving motor 12.

[0031] Furthermore, for the convenience of operation, a control panel 17 for controlling the operation of the oscillation motor 2 and the drive motor 12 should be provided on the front wall of the mixing box 1. The control panel 11 has an oscillation rate adjustment knob 18 for adjusting the vibration speed of the oscillation motor 2, a stirring speed adjustment knob 19 for adjusting the rotation speed of the drive motor 12, and a timing knob 20 for timing the working time of the oscillation motor 2.

[0032] When in use, it is only necessary to clamp the magnetic microparticle chemiluminescence kit 100 between the two clamping springs 9 of the clamping unit, and ensure that the bottom of the magnetic bead bottle on the magnetic microparticle chemiluminescence kit 100 is adapted to be clamped on the rotating seat 11; then the oscillation motor 2 can be started and the oscillation rate can be adjusted through the oscillation rate adjustment knob 18, so that the magnetic microparticle chemiluminescence kit 100 fixed on the oscillation platform 3 is mixed and oscillated with uniform force, and the duration of the mixing oscillation can be set through the timing knob 20, so that the mixing oscillation of the magnetic microparticle chemiluminescence kit 100 with uniform mixing force and consistent mixing time can be easily completed. In addition, the driving motor 12 can also be started by the stirring speed adjustment knob 19, so that the rotating seat 11 rotates, driving the magnetic bead bottle on the magnetic microparticle chemiluminescence kit 100 to rotate, and easily realizing the rotation and dispersion of the precipitated and agglomerated magnetic beads in the magnetic bead bottle without opening the cover, thereby ensuring the accuracy of subsequent test results.

Claims

1. A magnetic particle chemiluminescence kit mixing device, characterized in that: include A mixing box having a working chamber with an upper opening; An oscillating motor is arranged at the bottom of the working chamber, the motor shaft of the oscillating motor is vertically upward, and a circular horizontal rotating disk is provided at the upper end thereof, and the horizontal rotating disk is eccentrically connected to the motor shaft; An oscillating platform is horizontally arranged at the opening of the working chamber, and the bottom of the oscillating platform has a transmission sleeve sleeved on the outside of the horizontal turntable, and the outer wall of the transmission sleeve is uniformly distributed along the circumference with a pulling spring fixedly connected to the mixing box; A clamping unit, which is composed of a pair of clamping springs arranged side by side on the top surface of the oscillating platform, and a clamping portion for clamping the magnetic microparticle chemiluminescence kit is formed between the two clamping springs; The stirring unit is composed of a rotating seat arranged between the two clamping springs for clamping the magnetic particle chemiluminescence reagent box, and a driving motor for driving the rotating seat to rotate.

2. The magnetic particle chemiluminescence kit mixing device according to claim 1, characterized in that: The center of the bottom surface of the rotating seat has a rotating shaft vertically penetrated on the oscillating platform, and the rotating shaft is equipped with a transmission belt connected to the driving shaft of the driving motor. Three groups of stirring blades that are engaged with the magnetic bead bottle of the magnetic particle chemiluminescence kit are evenly distributed in a divergent shape at the center of the top surface of the rotating seat.

3. The magnetic particle chemiluminescence kit mixing device according to claim 1, characterized in that: The clamping units are two groups symmetrically arranged on the top surface of the oscillating platform, and the stirring units are two groups corresponding to the clamping units one by one.

4. The magnetic particle chemiluminescence kit mixing device according to claim 1, characterized in that: A control panel is arranged on the front wall of the mixing box, and the control panel has an oscillation rate adjustment knob, a stirring speed adjustment knob and a timing knob.

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